CN116269743A - Laser ablation treatment system guided by intraoperative real-time optical coherence imaging - Google Patents
Laser ablation treatment system guided by intraoperative real-time optical coherence imaging Download PDFInfo
- Publication number
- CN116269743A CN116269743A CN202211499971.6A CN202211499971A CN116269743A CN 116269743 A CN116269743 A CN 116269743A CN 202211499971 A CN202211499971 A CN 202211499971A CN 116269743 A CN116269743 A CN 116269743A
- Authority
- CN
- China
- Prior art keywords
- laser
- real
- time
- optical
- tissue
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 230000003287 optical effect Effects 0.000 title claims abstract description 73
- 238000011282 treatment Methods 0.000 title claims abstract description 53
- 238000000608 laser ablation Methods 0.000 title claims abstract description 45
- 238000003384 imaging method Methods 0.000 title claims abstract description 35
- 238000012544 monitoring process Methods 0.000 claims abstract description 33
- 206010028980 Neoplasm Diseases 0.000 claims abstract description 31
- 230000005855 radiation Effects 0.000 claims abstract description 26
- 238000000034 method Methods 0.000 claims abstract description 15
- 210000004204 blood vessel Anatomy 0.000 claims abstract description 8
- 230000011218 segmentation Effects 0.000 claims abstract description 8
- 239000013307 optical fiber Substances 0.000 claims description 31
- 238000013532 laser treatment Methods 0.000 claims description 22
- 230000003902 lesion Effects 0.000 claims description 18
- 230000017531 blood circulation Effects 0.000 claims description 14
- 230000008054 signal transmission Effects 0.000 claims description 13
- 201000010099 disease Diseases 0.000 claims description 12
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 12
- 230000008569 process Effects 0.000 claims description 11
- 230000000694 effects Effects 0.000 claims description 9
- 238000002583 angiography Methods 0.000 claims description 6
- 230000008859 change Effects 0.000 claims description 6
- 239000006185 dispersion Substances 0.000 claims description 4
- 238000007493 shaping process Methods 0.000 claims description 4
- 230000005540 biological transmission Effects 0.000 claims description 3
- 230000008878 coupling Effects 0.000 claims description 3
- 238000010168 coupling process Methods 0.000 claims description 3
- 238000005859 coupling reaction Methods 0.000 claims description 3
- 238000011156 evaluation Methods 0.000 claims description 3
- 230000005284 excitation Effects 0.000 claims description 3
- 230000007717 exclusion Effects 0.000 claims description 3
- 238000003709 image segmentation Methods 0.000 claims description 3
- 238000007781 pre-processing Methods 0.000 claims description 3
- 230000003595 spectral effect Effects 0.000 claims description 3
- 238000012549 training Methods 0.000 claims description 3
- 238000003745 diagnosis Methods 0.000 abstract description 6
- 210000001519 tissue Anatomy 0.000 description 41
- 230000006870 function Effects 0.000 description 11
- 238000012014 optical coherence tomography Methods 0.000 description 7
- 238000010586 diagram Methods 0.000 description 4
- 238000005516 engineering process Methods 0.000 description 4
- 238000002474 experimental method Methods 0.000 description 3
- 230000001613 neoplastic effect Effects 0.000 description 3
- 238000001356 surgical procedure Methods 0.000 description 3
- FCKYPQBAHLOOJQ-UHFFFAOYSA-N Cyclohexane-1,2-diaminetetraacetic acid Chemical compound OC(=O)CN(CC(O)=O)C1CCCCC1N(CC(O)=O)CC(O)=O FCKYPQBAHLOOJQ-UHFFFAOYSA-N 0.000 description 2
- 230000006378 damage Effects 0.000 description 2
- 230000007547 defect Effects 0.000 description 2
- 238000013461 design Methods 0.000 description 2
- 238000000605 extraction Methods 0.000 description 2
- 210000004185 liver Anatomy 0.000 description 2
- 238000012634 optical imaging Methods 0.000 description 2
- 238000002679 ablation Methods 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 238000012937 correction Methods 0.000 description 1
- 238000013135 deep learning Methods 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- 230000010354 integration Effects 0.000 description 1
- 230000002452 interceptive effect Effects 0.000 description 1
- 230000002427 irreversible effect Effects 0.000 description 1
- 238000002647 laser therapy Methods 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 210000000944 nerve tissue Anatomy 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 230000002093 peripheral effect Effects 0.000 description 1
- 238000010895 photoacoustic effect Methods 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 238000001228 spectrum Methods 0.000 description 1
- 230000000451 tissue damage Effects 0.000 description 1
- 231100000827 tissue damage Toxicity 0.000 description 1
- 230000009466 transformation Effects 0.000 description 1
- 230000008733 trauma Effects 0.000 description 1
- 230000004218 vascular function Effects 0.000 description 1
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B18/18—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves
- A61B18/20—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using laser
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B18/18—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves
- A61B18/20—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using laser
- A61B18/22—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using laser the beam being directed along or through a flexible conduit, e.g. an optical fibre; Couplings or hand-pieces therefor
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B2018/00571—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body for achieving a particular surgical effect
- A61B2018/00601—Cutting
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B2018/00636—Sensing and controlling the application of energy
- A61B2018/00642—Sensing and controlling the application of energy with feedback, i.e. closed loop control
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B2018/00636—Sensing and controlling the application of energy
- A61B2018/00696—Controlled or regulated parameters
- A61B2018/00702—Power or energy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B2018/00982—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body combined with or comprising means for visual or photographic inspections inside the body, e.g. endoscopes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B18/18—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves
- A61B18/20—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using laser
- A61B2018/2035—Beam shaping or redirecting; Optical components therefor
- A61B2018/20351—Scanning mechanisms
- A61B2018/20355—Special scanning path or conditions, e.g. spiral, raster or providing spot overlap
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B18/18—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves
- A61B18/20—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using laser
- A61B2018/2035—Beam shaping or redirecting; Optical components therefor
- A61B2018/20553—Beam shaping or redirecting; Optical components therefor with special lens or reflector arrangement
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B18/18—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves
- A61B18/20—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using laser
- A61B2018/2035—Beam shaping or redirecting; Optical components therefor
- A61B2018/205547—Controller with specific architecture or programmatic algorithm for directing scan path, spot size or shape, or spot intensity, fluence or irradiance
Abstract
The invention provides a laser ablation treatment system guided by intraoperative real-time optical coherence imaging, which comprises: the optical guiding module, the laser ablation module, the real-time monitoring and feedback module, the high-resolution three-dimensional information and the blood vessel function information obtained by the optical coherence imaging guiding module accurately divide the area of the tumor part, and accordingly, the power and the radiation time of the radiation laser source are accurately controlled; meanwhile, the temperature sensor monitors the tissue temperature at any time, and when the temperature exceeds a temperature set threshold range, the system pauses laser diagnosis and treatment to realize accurate laser ablation treatment; the method aims to solve the problems that the prior laser ablation treatment lacks real-time accurate segmentation of a tumor area and real-time monitoring and feedback of surrounding tissues of the tumor during operation, thereby realizing the real-time accurate laser ablation treatment of the tumor part during operation.
Description
Technical Field
The invention relates to the technical fields of optical imaging and life medicine, in particular to a laser ablation treatment system guided by real-time optical coherence imaging in operation.
Background
The incidence of neoplastic related lesions and diseases has been reported to rise gradually, and such lesions and diseases can now be treated and eliminated by laser therapy or the like. At present, laser treatment in surgery lacks a monitoring or feedback system in the whole treatment process, the treatment effect mainly depends on the experience of therapists, excessive treatment is easy to cause, and irreversible tissue damage caused by the excessive treatment can be irreparable. In recent years, the laser ablation treatment technology provides a new means for realizing the diagnosis and treatment integration of diseases by utilizing an optical imaging guiding technology.
Optical coherence imaging (Optical Coherence Tomography, OCT) has the characteristics of high resolution, no contact, and no damage. Optical coherence angiography imaging (Optical Coherence Tomography Angiography, OCTA) is an important branch of OCT technology, OCTA is a brand-new imaging mode established on the OCT technology, and displays the three-dimensional structure of tissue blood vessels with micron-scale resolution, so that the defect that OCT cannot provide blood flow information is overcome, blood flow information with different depths and high resolution of organs in a human body is obtained, and early treatment of diseases is realized.
The Laser ablation (Laser ablation) can treat in-vivo neoplastic lesions, can accurately and completely kill the neoplastic lesions, has shorter ablation operation time and avoids great trauma caused by the operation. However, when laser ablation is performed, local temperature is too high, so that the damage to peripheral normal tissues, nerves and blood vessels can be caused while the tumor focus is eliminated, and corresponding complications appear in patients.
Disclosure of Invention
The invention mainly aims to overcome the defects in the prior art, provides a laser ablation treatment system guided by intraoperative real-time optical coherence imaging, and aims to solve the problems that the current laser ablation treatment lacks real-time accurate segmentation of a tumor region and lacks real-time monitoring and feedback of tissues around the tumor during surgery.
The invention adopts the following technical scheme:
an intraoperative real-time optical coherence imaging guided laser ablation treatment system comprising: the system comprises an optical guiding module, a laser ablation module, a real-time monitoring and feedback module; wherein:
the optical guiding module comprises a tunable laser (1) which is used for an optical guiding module light-emitting device, and the scanning speed of the tunable laser determines the imaging speed of the system; the optical fiber coupler (2) is used for carrying out light energy proportion distribution after laser is coupled to a plurality of optical fibers; an optical fiber circulator (3) for a separable three-port device; the optical fiber collimator (4) is used for controlling the divergence angle of the laser and collimating the light beam after exiting from the optical fiber; a reflecting mirror (6) for reflecting the laser beam, and the laser beam returned from the original path interferes in the optical fiber coupler (2); the balance detector (7) is used for eliminating common mode noise, and consists of two balance photodiodes and an ultralow noise high-speed transimpedance amplifier, and the balance detector is used as a balance receiver by subtracting two optical input signals from each other; the signal transmission cable (16) is used for transmitting the original tissue optical signal acquired by the optical guiding module to the workstation (15), and the workstation processes the signal to judge the light energy of the tissue needing laser treatment;
the laser treatment module comprises a radiation laser (8) for emitting pulse excitation light to irradiate the irradiated object; a photodetector (9) for monitoring the light-emitting frequency; a wavelength division multiplexer (10) for coupling light beams of different wavelengths into the same optical fiber for transmission; the optical fiber collimator (11) is used for controlling the divergence angle of laser and collimating the light spots after coming out of the optical fiber; a two-dimensional scanning galvanometer (12) for deflecting an optical path, radiating a laser beam onto a tissue sample (13) and realizing equidistant high-frequency movement of light spots; the workstation (15) feeds back a first signal to the laser treatment module through the signal transmission cable (17), and the radiation laser starts to radiate tissues with laser with set power, and simultaneously evaluates the treatment effect in real time;
the real-time monitoring and feedback module comprises a temperature sensor (14) which is used for monitoring radiation temperature of tissues around tumors in real time during operation, and a workstation (15) is used for monitoring a returned tissue temperature signal in real time; when the tissue temperature reaches a set threshold, the workstation feeds back a second signal via a signal transmission cable (17) to stop laser irradiation.
Specifically, the method also comprises the pretreatment of original optical signals of the intraoperative real-time tissue:
the preprocessing includes, but is not limited to, de-background noise, wavenumber calibration, spectral shaping, and dispersion compensation.
Specifically, the method also comprises tumor boundary region segmentation, specifically:
the image preprocessed by the original optical signal of the real-time tissue in operation defines pixel point output as probability of a corresponding tissue lesion boundary, the result is normalized by a Softmax function, a marked clinical image is used as a true value, a loss function based on the combination of edge loss and mutual exclusion loss is constructed for continuous training, and finally the task of real-time image segmentation in operation is realized.
Specifically, the workstation processes the signals to judge the light energy of the tissue needing laser treatment, specifically:
judging laser treatment evaluation by referring to the three-dimensional structure information and blood flow function information acquired by the signal acquisition equipment of the optical guiding system; the acquired real-time tissue image in the post-segmentation operation is used for quantifying a lesion area, reconstructing a three-dimensional structure of the lesion area, and acquiring lesion information in the transverse direction and the depth direction; simultaneously, quantitatively analyzing blood flow velocity and blood vessel density information by using the acquired optical coherence angiography image; the change trend of the three-dimensional structure information and the blood flow function information is matched with the safety threshold calibrated by the professional medical staff, the laser energy range required for specific diseases or specific areas is obtained by utilizing the optical guiding module, and the intraoperative real-time laser energy setting for different diseases and different severity degrees is realized by the monitoring and feedback module.
Specifically, the real-time monitoring and feedback module specifically comprises:
the temperature sensor is used for monitoring radiation temperature of tissues around the tumor in real time during operation, and the workstation monitors the returned tissue temperature signals in real time; when the tissue temperature reaches the set threshold/treatment time and effect reaches the desired effect, the workstation feeds back a second signal via the signal transmission cable to stop the laser irradiation.
As can be seen from the above description of the present invention, compared with the prior art, the present invention has the following advantages:
the invention provides a laser ablation treatment system guided by intraoperative real-time optical coherence imaging, which comprises: the optical guiding module, the laser ablation module, the real-time monitoring and feedback module, the high-resolution three-dimensional information and the blood vessel function information obtained by the optical coherence imaging guiding module accurately divide the area of the tumor part, and accordingly, the power and the radiation time of the radiation laser source are accurately controlled; meanwhile, the temperature sensor monitors the tissue temperature at any time, and when the temperature exceeds a temperature set threshold range, the system pauses laser diagnosis and treatment to realize accurate laser ablation treatment; the method aims to solve the problems that the prior laser ablation treatment lacks real-time accurate segmentation of a tumor area and real-time monitoring and feedback of surrounding tissues of the tumor during operation, thereby realizing the real-time accurate laser ablation treatment of the tumor part during operation.
Drawings
FIG. 1 is a schematic diagram of an intraoperative real-time optical coherence imaging guided laser ablation treatment system in accordance with an embodiment of the present invention;
FIG. 2 is a logic flow diagram of an intraoperative real-time optical coherence imaging guided laser ablation treatment system in accordance with one embodiment of the present invention;
fig. 3 is a pre-experiment for verifying the feasibility of an intraoperative real-time optical coherence imaging guided laser ablation treatment system in accordance with embodiments of the invention.
The invention is further described in detail below with reference to the drawings and the specific examples.
Detailed Description
The invention provides a laser ablation treatment system guided by intraoperative real-time optical coherence imaging, which aims to solve the problems that the existing laser ablation treatment lacks of real-time accurate segmentation of a tumor area and lacks of real-time monitoring and feedback of tissues around the tumor in surgery, so that the intraoperative real-time accurate laser ablation treatment of the tumor part is realized.
Fig. 1 is a schematic diagram of a laser ablation treatment system guided by intraoperative real-time optical coherence imaging in accordance with an embodiment of the present invention, including: the system comprises an optical guiding module, a laser ablation module, a real-time monitoring and feedback module; wherein:
the optical guiding module comprises a tunable laser (1) which is used for an optical guiding module light-emitting device, and the scanning speed of the tunable laser determines the imaging speed of the system; the optical fiber coupler (2) is used for carrying out light energy proportion distribution after laser is coupled to a plurality of optical fibers; an optical fiber circulator (3) for a separable three-port device; the optical fiber collimator (4) is used for controlling the divergence angle of the laser and collimating the light beam after exiting from the optical fiber; a reflecting mirror (6) for reflecting the laser beam, and the laser beam returned from the original path interferes in the optical fiber coupler (2); the balance detector (7) is used for eliminating common mode noise, and consists of two balance photodiodes and an ultralow noise high-speed transimpedance amplifier, and the balance detector is used as a balance receiver by subtracting two optical input signals from each other; the signal transmission cable (16) is used for transmitting the original tissue optical signal acquired by the optical guiding module to the workstation (15), and the workstation processes the signal to judge the light energy of the tissue needing laser treatment;
the optical guiding module needs to accurately judge the position of tissue lesion, accurately judge the laser energy and the radiation time, and accordingly accurately control the intensity and the irradiation range of laser so as to realize accurate treatment of real-time optical coherence imaging guiding in operation. The optical coherence imaging guide module comprises a step of transmitting laser emitted by the sweep laser to a tumor part, scattering the laser back into an optical fiber after the sweep laser and biological tissues act, and interfering at an optical fiber coupler to amplify an optical signal of the tumor part; the photoelectric detector converts the amplified interference signals into photoelectric signals, and current signals are formed and transmitted to a workstation through a signal transmission cable for image information reconstruction;
the laser treatment module comprises a radiation laser (8) for emitting pulse excitation light to irradiate the irradiated object; a photodetector (9) for monitoring the light-emitting frequency; a wavelength division multiplexer (10) for coupling light beams of different wavelengths into the same optical fiber for transmission; the optical fiber collimator (11) is used for controlling the divergence angle of laser and collimating the light spots after coming out of the optical fiber; a two-dimensional scanning galvanometer (12) for deflecting an optical path, radiating a laser beam onto a tissue sample (13) and realizing equidistant high-frequency movement of light spots; the workstation (15) feeds back a first signal to the laser treatment module through the signal transmission cable (17), and the radiation laser starts to radiate tissues with laser with set power, and simultaneously evaluates the treatment effect in real time;
the laser treatment module can realize safe laser ablation treatment by focusing laser to a tumor part in a space light path according to the photoacoustic effect and the selective photo-thermal theory. The laser treatment module comprises a radiation laser, wherein a 532nm wavelength laser is adopted, the power is adjustable, and the diameter of a light spot focused on a tissue is about 300um; the radiation laser emitted by the laser of the laser ablation module is transmitted to the same optical fiber through the wavelength division multiplexer and the optical guiding module, and is expanded and collimated by the optical fiber collimator, and the optical path is deflected and focused at the tumor part by the two-dimensional galvanometer system, so that common-path focusing and real-time imaging guiding are realized;
the real-time monitoring and feedback module comprises a temperature sensor (14) which is used for monitoring radiation temperature of tissues around tumors in real time during operation, and a workstation (15) is used for monitoring a returned tissue temperature signal in real time; when the tissue temperature reaches a set threshold, the workstation feeds back a second signal via a signal transmission cable (17) to stop laser irradiation.
The monitoring and feedback module monitors and feeds back the temperature change of the tissue in real time by using the temperature sensor when carrying out laser treatment on the tumor part. The real-time monitoring and feedback module comprises a temperature sensor, is used for monitoring the radiation temperature of tissues around the tumor in real time, and a workstation monitors the returned tissue temperature signals in real time; the obtained optical coherence angiography image is utilized to further quantitatively analyze information such as blood flow velocity, blood vessel density and the like, and the change trend of the three-dimensional structure information and blood flow function information is matched with a safety threshold calibrated by a professional medical staff, so that a laser energy range required for specific diseases or specific areas is obtained; when the temperature of tissue around the tumor reaches a set threshold value, the workstation feeds back a signal through a signal transmission cable to stop laser radiation;
specifically, the workstation processes the signals to judge the light energy of the tissue needing laser treatment, specifically:
judging laser treatment evaluation by referring to the three-dimensional structure information and blood flow function information acquired by the signal acquisition equipment of the optical guiding system; the acquired real-time tissue image in the post-segmentation operation is used for quantifying a lesion area, reconstructing a three-dimensional structure of the lesion area, and acquiring lesion information in the transverse direction and the depth direction; simultaneously, quantitatively analyzing blood flow velocity and blood vessel density information by using the acquired optical coherence angiography image; the change trend of the three-dimensional structure information and the blood flow function information is matched with the safety threshold calibrated by the professional medical staff, the laser energy range required for specific diseases or specific areas is obtained by utilizing the optical guiding module, and the intraoperative real-time laser energy setting for different diseases and different severity degrees is realized by the monitoring and feedback module.
In order to realize laser ablation treatment guided by real-time optical coherence imaging in operation, it is important to acquire accurate image tumor areas. Optical signals at the original tissue are acquired in real time in operation, detailed structural information of the tissue sample is recovered as much as possible, image contrast is enhanced, and necessary preprocessing is needed for interference signals before fast Fourier transformation is carried out. The pretreatment processes mainly comprise background noise removal, wave number calibration, spectrum shaping, dispersion compensation and the like; the preprocessed image defines pixel point output as probability of a corresponding tissue lesion boundary, the result is normalized by a Softmax function, a small amount of marked clinical images are used as a true value, a loss function based on the combination of edge loss and mutual exclusion loss is constructed for continuous training, and finally, the task of real-time image segmentation is realized in operation; the optical coherence imaging system obtains an accurate image of the tumor part through processing, obtains the power and time of laser ablation treatment through matching analysis of three-dimensional structure information and blood flow function information of the image with a safety threshold value calibrated by a professional medical staff, and judges whether re-radiation treatment is needed or not and controls the intensity of a laser light source when the laser ablation treatment is carried out according to the power and time.
FIG. 2 is a logic flow diagram of an intraoperative real-time optical coherence imaging guided laser ablation treatment system in accordance with one embodiment of the present invention;
the OCT signal of the original tissue is firstly subjected to signal calibration pretreatment, which comprises the following steps: removing background noise, beam calibration, spectral shaping and dispersion compensation; the feature extraction after pretreatment comprises the following steps: extracting phase, phase correction, phase variance, extracting intensity, filtering clutter and intensity variance; and dividing the lesion area based on the extracted features by a deep learning segmentation algorithm, and then guiding a laser ablation screen to control links to set specific laser parameters for laser treatment, and monitoring and evaluating in real time.
The feasibility of the invention was further verified by taking laser irradiation of ex vivo fresh livers as an example. The laser ablation treatment system designed in the experiment is a radiation part imitating an actual laser treatment system and is widely applied in hospitals. The invention adopts a 700-1100nm wavelength pulse laser, and in order to observe the laser radiation process guided by real-time optical coherence imaging, the invention selects a laser with relatively low power to carry out image change of laser radiation observation on the isolated fresh liver. As shown in fig. 3, the interference signals at the selected area are collected, the collected optical coherence signals (such as amplitude, frequency, etc.) are analyzed, the laser radiation range is carried out at the selected area by utilizing a segmentation algorithm, and the effect and stage of the laser treatment are judged from the structural information and the functional information of the selected area, so that the laser output power is guided to be set; and then determining and calibrating the variation trend of the extraction quantity according to nodes calibrated by professionals in the medical field, and matching to obtain a threshold range of a temperature control link aiming at specific diseases or specific areas, wherein the laser diagnosis and treatment process at each moment can be systematically monitored and fed back, and the system pauses the laser diagnosis and treatment when the temperature exceeds the threshold range set by the temperature, so that the purpose of control is achieved. In summary, the pre-experiments of the present invention demonstrate the feasibility of the proposed optical coherence imaging guided laser irradiation process.
According to the intraoperative real-time optical coherence imaging guided laser ablation treatment system, the high-resolution three-dimensional information and the vascular function information acquired by the optical coherence imaging guiding module are used for accurately dividing the area of a tumor part, so that the power and the radiation time of a radiation laser source are accurately controlled; meanwhile, the temperature sensor monitors the tissue temperature at any time, and when the temperature exceeds a temperature set threshold range, the system pauses laser diagnosis and treatment, so that accurate laser ablation treatment is realized.
The foregoing is merely illustrative of specific embodiments of the present invention, but the design concept of the present invention is not limited thereto, and any insubstantial modification of the present invention by using the design concept shall fall within the scope of the present invention.
Claims (5)
1. An intraoperative real-time optical coherence imaging guided laser ablation treatment system, comprising: the system comprises an optical guiding module, a laser ablation module, a real-time monitoring and feedback module; wherein:
the optical guiding module comprises a tunable laser (1) which is used for an optical guiding module light-emitting device, and the scanning speed of the tunable laser determines the imaging speed of the system; the optical fiber coupler (2) is used for carrying out light energy proportion distribution after laser is coupled to a plurality of optical fibers; an optical fiber circulator (3) for a separable three-port device; the optical fiber collimator (4) is used for controlling the divergence angle of the laser and collimating the light beam after exiting from the optical fiber; a reflecting mirror (6) for reflecting the laser beam, and the laser beam returned from the original path interferes in the optical fiber coupler (2); the balance detector (7) is used for eliminating common mode noise, and consists of two balance photodiodes and an ultralow noise high-speed transimpedance amplifier, and the balance detector is used as a balance receiver by subtracting two optical input signals from each other; the signal transmission cable (16) is used for transmitting the original tissue optical signal acquired by the optical guiding module to the workstation (15), and the workstation processes the signal to judge the light energy of the tissue needing laser treatment;
the laser treatment module comprises a radiation laser (8) for emitting pulse excitation light to irradiate the irradiated object; a photodetector (9) for monitoring the light-emitting frequency; a wavelength division multiplexer (10) for coupling light beams of different wavelengths into the same optical fiber for transmission; the optical fiber collimator (11) is used for controlling the divergence angle of laser and collimating the light spots after coming out of the optical fiber; a two-dimensional scanning galvanometer (12) for deflecting an optical path, radiating a laser beam onto a tissue sample (13) and realizing equidistant high-frequency movement of light spots; the workstation (15) feeds back a first signal to the laser treatment module through the signal transmission cable (17), and the radiation laser starts to radiate tissues with laser with set power, and simultaneously evaluates the treatment effect in real time;
the real-time monitoring and feedback module comprises a temperature sensor (14) which is used for monitoring radiation temperature of tissues around tumors in real time during operation, and a workstation (15) is used for monitoring a returned tissue temperature signal in real time; when the tissue temperature reaches a set threshold, the workstation feeds back a second signal via a signal transmission cable (17) to stop laser irradiation.
2. An intraoperative real-time optical coherence imaging guided laser ablation treatment system as in claim 1, further comprising pretreatment of intraoperative real-time tissue raw optical signals:
the preprocessing includes, but is not limited to, de-background noise, wavenumber calibration, spectral shaping, and dispersion compensation.
3. An intraoperative real-time optical coherence imaging guided laser ablation treatment system as in claim 2, further comprising tumor border region segmentation, in particular:
the image preprocessed by the original optical signal of the real-time tissue in operation defines pixel point output as probability of a corresponding tissue lesion boundary, the result is normalized by a Softmax function, a marked clinical image is used as a true value, a loss function based on the combination of edge loss and mutual exclusion loss is constructed for continuous training, and finally the task of real-time image segmentation in operation is realized.
4. The intraoperative real-time optical coherence imaging guided laser ablation treatment system of claim 1, wherein the workstation processes the signals to determine the light energy needed by the tissue for laser treatment, specifically:
judging laser treatment evaluation by referring to the three-dimensional structure information and blood flow function information acquired by the signal acquisition equipment of the optical guiding system; the acquired real-time tissue image in the post-segmentation operation is used for quantifying a lesion area, reconstructing a three-dimensional structure of the lesion area, and acquiring lesion information in the transverse direction and the depth direction; simultaneously, quantitatively analyzing blood flow velocity and blood vessel density information by using the acquired optical coherence angiography image; the change trend of the three-dimensional structure information and the blood flow function information is matched with the safety threshold calibrated by the professional medical staff, the laser energy range required for specific diseases or specific areas is obtained by utilizing the optical guiding module, and the intraoperative real-time laser energy setting for different diseases and different severity degrees is realized by the monitoring and feedback module.
5. The intraoperative real-time optical coherence imaging guided laser ablation treatment system of claim 1, wherein the real-time monitoring and feedback module specifically comprises:
the temperature sensor is used for monitoring radiation temperature of tissues around the tumor in real time during operation, and the workstation monitors the returned tissue temperature signals in real time; when the tissue temperature reaches the set threshold/treatment time and effect reaches the desired effect, the workstation feeds back a second signal via the signal transmission cable to stop the laser irradiation.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202211499971.6A CN116269743A (en) | 2022-11-28 | 2022-11-28 | Laser ablation treatment system guided by intraoperative real-time optical coherence imaging |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202211499971.6A CN116269743A (en) | 2022-11-28 | 2022-11-28 | Laser ablation treatment system guided by intraoperative real-time optical coherence imaging |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN116269743A true CN116269743A (en) | 2023-06-23 |
Family
ID=86785731
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202211499971.6A Pending CN116269743A (en) | 2022-11-28 | 2022-11-28 | Laser ablation treatment system guided by intraoperative real-time optical coherence imaging |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN116269743A (en) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN116884570A (en) * | 2023-09-06 | 2023-10-13 | 南京诺源医疗器械有限公司 | Intraoperative real-time simulation curative effect evaluation system based on image processing |
| CN117204943A (en) * | 2023-11-07 | 2023-12-12 | 南京康友医疗科技有限公司 | Power control method and system of radio frequency ablation catheter |
| CN117618104A (en) * | 2024-01-25 | 2024-03-01 | 广州信筑医疗技术有限公司 | Laser surgery system with intraoperative monitoring function |
| CN117618104B (en) * | 2024-01-25 | 2024-04-26 | 广州信筑医疗技术有限公司 | Laser surgery system with intraoperative monitoring function |
-
2022
- 2022-11-28 CN CN202211499971.6A patent/CN116269743A/en active Pending
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN116884570A (en) * | 2023-09-06 | 2023-10-13 | 南京诺源医疗器械有限公司 | Intraoperative real-time simulation curative effect evaluation system based on image processing |
| CN116884570B (en) * | 2023-09-06 | 2023-12-12 | 南京诺源医疗器械有限公司 | Intraoperative real-time simulation curative effect evaluation system based on image processing |
| CN117204943A (en) * | 2023-11-07 | 2023-12-12 | 南京康友医疗科技有限公司 | Power control method and system of radio frequency ablation catheter |
| CN117204943B (en) * | 2023-11-07 | 2024-02-09 | 南京康友医疗科技有限公司 | Power control method and system of radio frequency ablation catheter |
| CN117618104A (en) * | 2024-01-25 | 2024-03-01 | 广州信筑医疗技术有限公司 | Laser surgery system with intraoperative monitoring function |
| CN117618104B (en) * | 2024-01-25 | 2024-04-26 | 广州信筑医疗技术有限公司 | Laser surgery system with intraoperative monitoring function |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN116269743A (en) | Laser ablation treatment system guided by intraoperative real-time optical coherence imaging | |
| US5305759A (en) | Examined body interior information observing apparatus by using photo-pulses controlling gains for depths | |
| US20090124902A1 (en) | Method for in vivo tissue classification | |
| JP5743957B2 (en) | Photoacoustic image generation apparatus and method | |
| US9833187B2 (en) | Detection, diagnosis and monitoring of osteoporosis by a photo-acoustic method | |
| EP2016891B1 (en) | Medical apparatus for obtaining information indicative of internal state of an object based on physical interaction between ultrasound wave and light | |
| Esenaliev et al. | Laser optoacoustic imaging for breast cancer diagnostics: limit of detection and comparison with x-ray and ultrasound imaging | |
| CN101410069B (en) | Methods and systems for providing electromagnetic radiation to at least one portion of a sample using conformal laser therapy procedures | |
| JPH11514549A (en) | Laser optical acoustic imaging equipment | |
| JP2009535098A (en) | Tissue variation measurement using optical fiber | |
| JP2010094500A (en) | Measurement apparatus and measurement method | |
| US10746706B2 (en) | Photoacoustic physio-chemical tissue analysis | |
| CN110361357B (en) | Single-array-element photoacoustic spectrum signal acquisition system and method for skin detection | |
| JPH04135551A (en) | Optical three-dimensional image observing device | |
| JP2024023852A (en) | Multichannel orthogonal convolutional neural network | |
| CN111481171A (en) | Multi-mode monitoring system and method for brain surgery | |
| US10973576B2 (en) | Optical treatment apparatus and control method therefor | |
| KR101427760B1 (en) | Device and method of biomedical photoacoustic imaging device using induced laser | |
| CN116421304A (en) | Method and apparatus for selective photothermolysis | |
| CN114668369A (en) | Diagnosis and treatment integrated probe and diagnosis and treatment system | |
| CN114532985A (en) | Photo-acoustic imaging-based quantitative photo-thermal irradiation device and method | |
| CN212415682U (en) | Device for monitoring photodynamic therapy effect by oxygen saturation endoscope | |
| Khan et al. | Photoacoustic imaging for characterization of radiofrequency ablated cardiac tissues | |
| TWI616190B (en) | System and operation method of acoustic-actuated optical coherence enhanced imaging lens | |
| JP6066230B2 (en) | Photoacoustic image generation apparatus and operation method thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination |