CN116223824A - Sample analyzer and cleaning method - Google Patents

Sample analyzer and cleaning method Download PDF

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Publication number
CN116223824A
CN116223824A CN202111477716.7A CN202111477716A CN116223824A CN 116223824 A CN116223824 A CN 116223824A CN 202111477716 A CN202111477716 A CN 202111477716A CN 116223824 A CN116223824 A CN 116223824A
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CN
China
Prior art keywords
sample
cleaning
needle
sample needle
controlling
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Pending
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CN202111477716.7A
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Chinese (zh)
Inventor
贾腾
赵键宏
汪云
韩维春
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Shenzhen Mindray Bio Medical Electronics Co Ltd
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Shenzhen Mindray Bio Medical Electronics Co Ltd
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Priority to CN202111477716.7A priority Critical patent/CN116223824A/en
Publication of CN116223824A publication Critical patent/CN116223824A/en
Pending legal-status Critical Current

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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/00584—Control arrangements for automatic analysers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B08—CLEANING
    • B08B—CLEANING IN GENERAL; PREVENTION OF FOULING IN GENERAL
    • B08B3/00—Cleaning by methods involving the use or presence of liquid or steam
    • B08B3/04—Cleaning involving contact with liquid
    • B08B3/10—Cleaning involving contact with liquid with additional treatment of the liquid or of the object being cleaned, e.g. by heat, by electricity or by vibration
    • B08B3/102—Cleaning involving contact with liquid with additional treatment of the liquid or of the object being cleaned, e.g. by heat, by electricity or by vibration with means for agitating the liquid
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B08—CLEANING
    • B08B—CLEANING IN GENERAL; PREVENTION OF FOULING IN GENERAL
    • B08B3/00—Cleaning by methods involving the use or presence of liquid or steam
    • B08B3/04—Cleaning involving contact with liquid
    • B08B3/10—Cleaning involving contact with liquid with additional treatment of the liquid or of the object being cleaned, e.g. by heat, by electricity or by vibration
    • B08B3/12—Cleaning involving contact with liquid with additional treatment of the liquid or of the object being cleaned, e.g. by heat, by electricity or by vibration by sonic or ultrasonic vibrations
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
    • G01N35/025—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations having a carousel or turntable for reaction cells or cuvettes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
    • G01N35/1004—Cleaning sample transfer devices
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
    • G01N35/04—Details of the conveyor system
    • G01N2035/0401—Sample carriers, cuvettes or reaction vessels
    • G01N2035/0437—Cleaning cuvettes or reaction vessels
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Chemical & Material Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)

Abstract

The invention discloses a sample analyzer and a cleaning method, the sample analyzer comprises: a sample carrier mechanism, a reaction mechanism, a sample dispensing mechanism, a first container, a first wash basin, and a controller configured to: controlling the first moving part to drive the sample needle to suck the strongly oxidizing cleaning liquid in the first container; controlling the sample needle to discharge a strongly oxidizing cleaning liquid in the first cleaning tank; controlling the sample needle to be inserted into a first cleaning pool so as to clean the sample needle through the strong oxidizing cleaning liquid. The sample analyzer cleans the sample needle through the strong oxidizing cleaning liquid, can clean the sample stained on the sample needle, avoids poor pollution, and particularly has an excellent cleaning effect on fibrin in the sample.

Description

Sample analyzer and cleaning method
Technical Field
The invention relates to the technical field of sample analyzers, in particular to a sample analyzer and a cleaning method.
Background
The diagnosis device such as a biochemical analyzer needs to fill a sample and a reagent into a reaction cup by a sample needle and a reagent needle, and a stirring rod needs to stir a reaction liquid added into the reaction cup. Because the sample needle, reagent needle, stirring rod and reaction cup are reusable devices, they need to be cleaned during each cycle. The sample of the biochemical analyzer is mainly a blood sample, a device contacting the sample cannot be completely cleaned by conventional cleaning, pollution is gradually accumulated after long-term use, so that the cross pollution rate is increased, and the performance requirement of the instrument cannot be met, so that the sample is required to be subjected to enhanced cleaning by enhanced cleaning liquid, but the existing enhanced cleaning liquid still has the problem of poor cleaning effect, and particularly the cleaning effect on fibrin in blood is poor.
Disclosure of Invention
In view of the above problems in the prior art, the present invention provides a sample analyzer and a cleaning method. The technical scheme adopted by the embodiment of the invention is as follows.
In one aspect, an embodiment of the present invention provides a sample analyzer, including:
a sample carrier provided with at least one sample site for placing a sample container for holding a sample;
the reaction mechanism comprises at least one placement position, wherein the placement position is used for placing a reaction cup and incubating a reaction liquid in the reaction cup, and the reaction liquid is formed by the sample;
a sample dispensing mechanism including a first moving member and a sample needle provided on the first moving member; the first moving part is used for driving the sample needle to move between the sample position and the placement position so as to suck the sample at the sample position and discharge the sample at the placement position through the sample needle;
a first container containing a strongly oxidizing cleaning liquid, the first container being located on the locus of movement of the sample needle;
a first washing tank located on a moving track of the sample needle;
A controller configured to:
controlling the first moving part to drive the sample needle to suck the strongly oxidizing cleaning liquid in the first container;
controlling the sample needle to discharge a strongly oxidizing cleaning liquid in the first cleaning tank;
controlling the sample needle to be inserted into a first cleaning pool so as to clean the sample needle through the strong oxidizing cleaning liquid.
In some embodiments, the sample analyzer further comprises a first fluid path support mechanism for providing wash water to the first wash tank; the controller is further configured to:
the first liquid path support mechanism is controlled to supply the cleaning water to the first cleaning tank before the sample needle discharges the strongly oxidizing cleaning liquid in the first cleaning tank, and the cleaning water is mixed with the strongly oxidizing cleaning liquid after the sample needle discharges the strongly oxidizing cleaning liquid in the first cleaning tank.
In some embodiments, the sample analyzer further comprises an ultrasonic assembly, the controller being specifically configured to:
controlling the sample needle to discharge the sucked part of the strong oxidizing cleaning liquid to the first cleaning tank, and retaining the part of the strong oxidizing cleaning liquid in the cavity of the sample needle;
Controlling the sample needle to be inserted into the first cleaning pool;
and controlling the ultrasonic assembly to provide ultrasonic vibration for the diluted strong-oxidizing cleaning liquid in the first cleaning pool so as to clean the inner wall and the outer wall of the sample needle in an ultrasonic manner.
In some embodiments, the sample analyzer further comprises a second wash tank positioned on a movement trajectory of the sample needle, and a second fluid path support mechanism that provides wash water to the second wash tank, the controller further configured to:
controlling the first moving part to drive the sample needle to move to the second cleaning pool, and controlling the second liquid path supporting mechanism to provide cleaning water for flushing the sample needle.
In some embodiments, the controller is further configured to:
controlling the sample needle to move to the reaction position;
and controlling the sample needle to discharge the strong oxidizing cleaning liquid to the reaction cup so as to clean the reaction cup through the strong oxidizing cleaning liquid.
In some embodiments, the sample dispensing mechanism further comprises a third fluid path support mechanism for providing motive force for aspiration and expulsion of the sample needle and for providing wash water to the sample needle; the controller is further configured to:
And controlling the third liquid path supporting mechanism to inject cleaning water into the reaction cup through the sample needle so as to dilute the strong oxidizing cleaning liquid, and cleaning the reaction cup through the diluted strong oxidizing cleaning liquid.
In some embodiments, the sample analyzer further comprises:
the reagent carrying mechanism is provided with at least one reagent position, the reagent position is used for placing a reagent container, and the reagent container is used for containing a reagent;
a reagent dispensing mechanism including a second moving member and a reagent needle provided on the second moving member, the second moving member being configured to drive the reagent needle to move between the reagent position and the placement position, aspirate a reagent at the reagent position through the reagent needle and discharge a reagent at the placement position so that a sample and a reagent in the reaction cup are mixed to form the reaction liquid;
the third cleaning pool is arranged on the moving track of the reagent needle;
a fourth liquid path support mechanism for providing washing water to the third washing tank;
the controller is further configured to:
Controlling the fourth liquid path supporting mechanism to inject cleaning water into the third cleaning tank;
controlling the second moving part to drive the reagent needle to move to the third washing tank, and sucking washing water from the third washing tank through the reagent needle;
and controlling the reagent needle to inject cleaning water into the reaction cup so as to dilute the strong oxidizing cleaning liquid, and cleaning the reaction cup through the diluted strong oxidizing cleaning liquid.
In some embodiments, the sample analyzer further comprises:
the mixing device comprises a third moving mechanism, a driving mechanism and a mixing rod piece arranged on the third moving mechanism, wherein the third moving mechanism is used for driving the mixing rod piece to move between the placing position and the reaction position, and the driving mechanism is used for driving the mixing rod piece to perform stirring operation:
the controller is further configured to:
and controlling the third moving mechanism to move the mixing rod piece to the reaction position, and controlling the driving mechanism to drive the mixing rod piece to stir the diluted strong-oxidizing cleaning liquid in the reaction cup so as to clean the mixing rod piece and the reaction cup through the diluted strong-oxidizing cleaning liquid.
In some embodiments, the sample analyzer includes a plurality of the sample dispensing mechanisms, and the first containers are disposed on the movement trajectories of the sample needles of the respective sample dispensing mechanisms.
In some embodiments, the sample analyzer further comprises:
the second container is filled with a strongly acidic cleaning solution and is positioned on the moving track of the sample needle:
the controller is further configured to:
controlling the first moving mechanism to drive the sample needle to suck the strongly acidic cleaning solution in the second container;
controlling the sample needle to discharge the strongly acidic cleaning liquid in the cleaning tank;
controlling the sample needle to be inserted into the cleaning pool so as to clean the sample needle through the strongly acidic cleaning liquid;
and/or
The sample analyzer further comprises:
a third container containing a strongly alkaline cleaning solution, the third container being located on the locus of movement of the sample needle;
the controller is further configured to:
controlling the first moving mechanism to drive the sample needle to suck the strong alkaline cleaning liquid in the third container;
controlling the sample needle to discharge the strong alkaline cleaning liquid in the cleaning pool;
Controlling the sample needle to be inserted into the cleaning pool so as to clean the sample needle through the strong alkaline cleaning liquid.
In some embodiments, the controller is further configured to:
and under the condition that the sample needle executes the preset operation of the first time or the accumulated time length of the sample analyzer for executing the detection operation reaches the preset time length, controlling the sample needle to suck the strong oxidizing cleaning liquid from the first container, and executing the cleaning of the sample needle for the second time through the strong oxidizing cleaning liquid.
In some embodiments, the strongly oxidizing cleaning solution is a sodium hypochlorite solution.
In another aspect, the embodiment of the invention provides a cleaning method applied to a sample analyzer, the cleaning method includes:
controlling the first moving part to drive the sample needle to suck the strong-oxidizing cleaning liquid in the first container;
controlling the sample needle to discharge a strong oxidizing cleaning liquid in a cleaning pool;
controlling the sample needle to be inserted into the cleaning pool so as to clean the sample needle through the strong oxidizing cleaning liquid.
In some embodiments, the cleaning method further comprises:
controlling the sample needle to move to a reaction position;
And controlling the sample needle to discharge the strong oxidizing cleaning liquid to the reaction cup so as to clean the reaction cup through the strong oxidizing cleaning liquid.
The sample analyzer provided by the embodiment of the invention is provided with the first container for containing the strong oxidizing cleaning liquid, when the sample needle needs to be cleaned, the first moving part is controlled by the controller to drive the sample needle to absorb the strong oxidizing cleaning liquid from the first container, the strong oxidizing cleaning liquid is discharged into the first cleaning pool, and then the sample needle is inserted into the first cleaning pool so as to clean the sample needle through the strong oxidizing cleaning liquid, so that the contaminated sample on the sample needle can be cleaned, poor pollution is avoided, and particularly, the sample analyzer has an excellent cleaning effect on fibrin in the sample.
Drawings
Fig. 1 to 3 are schematic views of a portion of a sample analyzer according to an embodiment of the invention at different viewing angles;
FIG. 4 is a block diagram of a sample analyzer according to an embodiment of the present invention;
FIG. 5 is a schematic view of the structure of an ultrasonic assembly;
fig. 6 is a flowchart of a cleaning method according to an embodiment of the invention.
Reference numerals illustrate:
10-sample loading mechanism;
20-reaction mechanism; 21-a reaction tray; 22-reaction cup;
30-a sample dispensing mechanism; 31-sample needle; 32-a first moving part; 33-a first container; 34-a second container; 35-a third container; 36-a first cleaning tank; 37-an ultrasonic assembly; 38-an ultrasonic transducer; 39-a transfer member;
40-detecting means;
50-a reagent carrying mechanism;
60-a reagent dispensing mechanism; 61-a second moving part; 62-a reagent needle; 63-a third cleaning tank;
70-uniformly mixing device; 71-a third movement mechanism; 72-uniformly mixing rod pieces;
80-controller.
Detailed Description
Various aspects and features of the present invention are described herein with reference to the accompanying drawings.
It should be understood that various modifications may be made to the embodiments of the application herein. Therefore, the above description should not be taken as limiting, but merely as exemplification of the embodiments. Other modifications within the scope and spirit of the invention will occur to persons of ordinary skill in the art.
The accompanying drawings, which are incorporated in and constitute a part of this specification, illustrate embodiments of the invention and, together with a general description of the invention given above, and the detailed description of the embodiments given below, serve to explain the principles of the invention.
These and other characteristics of the invention will become apparent from the following description of a preferred form of embodiment, given as a non-limiting example, with reference to the accompanying drawings.
It is also to be understood that, although the invention has been described with reference to some specific examples, those skilled in the art can certainly realize many other equivalent forms of the invention.
The above and other aspects, features and advantages of the present invention will become more apparent in light of the following detailed description when taken in conjunction with the accompanying drawings.
Specific embodiments of the present invention will be described hereinafter with reference to the accompanying drawings; however, it is to be understood that the disclosed embodiments are merely exemplary of the invention, which can be embodied in various forms. Well-known and/or repeated functions and constructions are not described in detail to avoid obscuring the invention in unnecessary or unnecessary detail. Therefore, specific structural and functional details disclosed herein are not intended to be limiting, but merely as a basis for the claims and as a representative basis for teaching one skilled in the art to variously employ the present invention in virtually any appropriately detailed structure.
The specification may use the word "in one embodiment," "in another embodiment," "in yet another embodiment," or "in other embodiments," which may each refer to one or more of the same or different embodiments in accordance with the invention.
The embodiment of the invention provides a sample analyzer, which comprises a sample bearing mechanism, a reaction mechanism, a sample dispensing mechanism, a first container, a first cleaning pool and a controller. Wherein the sample carrier is provided with at least one sample site for placing a sample container for holding a sample; the reaction mechanism comprises at least one placement position, wherein the placement position is used for placing a reaction cup and incubating a reaction liquid in the reaction cup, and the reaction liquid is formed by the sample; the sample dispensing mechanism comprises a first moving part and a sample needle arranged on the first moving part; the first moving part is used for driving the sample needle to move between the sample position and the placement position so as to suck the sample at the sample position and discharge the sample at the placement position through the sample needle; the first container is internally provided with a strong oxidizing cleaning solution, and is positioned on the moving track of the sample needle; the first cleaning pool is positioned on the moving track of the sample needle; the controller is configured to: controlling the first moving part to drive the sample needle to suck the strongly oxidizing cleaning liquid in the first container; controlling the sample needle to discharge a strongly oxidizing cleaning liquid in the first cleaning tank; controlling the sample needle to be inserted into a first cleaning pool so as to clean the sample needle through the strong oxidizing cleaning liquid.
The sample analyzer provided by the embodiment of the invention is provided with the first container for containing the strong oxidizing cleaning liquid, when the sample needle needs to be cleaned, the first moving part is controlled by the controller to drive the sample needle to be cleaned from the strong oxidizing cleaning liquid in the western region of the first container, the strong oxidizing cleaning liquid is discharged into the first cleaning pool, and then the sample needle is inserted into the first cleaning pool so as to clean the sample needle through the strong oxidizing cleaning liquid, so that the contaminated sample on the sample needle can be cleaned, poor pollution is avoided, and particularly, the sample analyzer has an excellent cleaning effect on fibrin in the sample.
The specific structure and principle of the sample analyzer according to the embodiment of the present invention will be described in detail with reference to the accompanying drawings and the specific embodiments.
Referring to fig. 1 to 4, a sample analyzer according to an embodiment of the present invention may include a sample carrying mechanism 10, a reaction mechanism 20, a sample dispensing mechanism 30, a first container 33, a first washing cell 36, and a controller 80.
The sample carrier 10 is for carrying a sample, the sample carrier 10 being provided with at least one sample site for placing a sample container for receiving the sample. Alternatively, the sample carrier 10 may comprise a sample tray, which may comprise a plurality of sample locations where sample tubes, such as sample tubes, may be placed, and which may be maneuvered to a corresponding position by rotating its tray structure, e.g. by rotating the sample tray to rotate the sample tubes onto the movement track of the sample needle 31 so that the sample needle 31 can draw samples from the sample tubes.
The reaction mechanism 20 is used to receive a sample and incubate the reaction solution. The reaction mechanism 20 includes at least one placement site for placing a reaction cuvette 22, where the reaction site is a container for holding a sample, and the sample is incubated in the reaction cuvette 22 to form a reaction solution. Alternatively, the reaction mechanism 20 may include a reaction disk 21, the reaction disk 21 may have a disk shape, the reaction disk 21 may have one or more placement sites for placing the reaction cups 22, and the reaction cups 22 may be uniformly distributed on the reaction disk 21. The reaction disk 21 can rotate and drive the reaction cup 22 in the placement position to rotate so as to schedule the reaction cup 22. Alternatively, the reaction cups 22 may be arranged in a circular ring shape on the reaction plate 21, and one or more circles of placement positions may be arranged on the reaction plate 21. For example, two rings of the reaction cups 22 of the inner ring and the outer ring may be respectively arranged along two concentric circles on the reaction disk 21, and 206 reaction cups 22 may be respectively arranged on the inner ring and the outer ring.
The sample dispensing mechanism 30 may include a sample needle 31, a first moving member 32, and a third liquid path support mechanism, the sample needle 31 being disposed on the first moving member 32; the first moving part 32 is used for driving the sample needle 31 to move on the moving track thereof; the third liquid path support mechanism is for providing suction and discharge power to the sample needle 31. For example, when the sample tray rotates the sample position where the sample tube is placed onto the movement locus of the sample needle 31 and the reaction tray 21 also rotates one placement position where the cuvette 22 is placed onto the movement locus of the sample needle 31, the first moving member 32 may drive the sample needle 31 to move between the sample position and the placement position, and the third liquid path support mechanism may provide suction and discharge power to the sample needle 31 so that the sample needle 31 can suck the sample from the sample tube of the sample position and discharge the sample in the cuvette 22 of the placement position, thereby achieving the dispensing of the sample.
Alternatively, the third liquid path supporting mechanism may include a driving pump, an electric control valve, a washing water container for containing washing water, the driving pump being connected to the washing water container and the sample needle 31 through the electric control valve, respectively, and a liquid path connecting the driving pump, the electric control valve, the sample needle 31 and the washing water container being also filled with washing water as a power transmission medium. When the power for sucking and discharging the sample is required to be provided for the sample needle 31, the electrically controlled valve can be controlled to communicate with the driving pump of the sample needle 31, when the driving pump pumps the cleaning water, the power for sucking the sample is transmitted to the sample needle 31 through the cleaning water in the liquid path, and when the driving pump outputs the cleaning water, the power for discharging the sample is transmitted to the sample needle 31 through the cleaning water in the liquid path. The third liquid path support mechanism may also supply the washing water to the sample needle 31 so that the washing water can be contained in the sample needle 31, and even the washing water can be discharged to the outside of the sample needle 31. When it is necessary to supply the washing water to the sample needle 31, the electrically controlled valve may be controlled to communicate the washing water container with the drive pump, the drive pump may be controlled to suck the washing water from the washing water container, the electrically controlled valve may be switched to communicate the drive pump with the sample needle 31, and the drive pump may be controlled to convey the sucked washing water to the sample needle 31. Alternatively, the drive pump may be, for example, a syringe or other power device capable of drawing in and expelling liquid.
The first container 33 is located on the moving track of the sample needle 31. The first container 33 contains a strong oxidizing cleaning solution, which may be a cleaning solution containing a strong oxidizing agent. Since the strong oxidizing agent can destroy the carbon chain of the protein and deform the protein, the addition of the strong oxidizing agent to the cleaning solution can effectively clean the protein, such as fibrin, in the stained sample. In practice, a plurality of types of strong oxidizing agents may be selected as long as the purpose of removing proteins in the sample can be achieved. Optionally, the strong oxidizing cleaning solution may be sodium hypochlorite solution, which has a higher cleaning effect. Alternatively, the sample analyzer may include a plurality of the sample dispensing mechanisms 30, and the first containers 33 may be provided on the moving track of the sample needle 31 of each of the sample dispensing mechanisms 30, respectively. Of course, when the movement paths of the plurality of sample pins 31 have an intersection, only one first container 33 may be provided at the intersection, and the plurality of sample pins 31 may be arranged so as to share one first container 33.
The first washing bath 36 is located on the moving track of the sample needle 31. The first washing tank 36 may be a washing tank dedicated to washing the sample needle 31, or may be a washing tank for washing a plurality of objects to be washed including the sample needle 31. Alternatively, the first washing tank 36 may be an open-top container so that, for example, the sample needle 31 waits for the washing object to be able to extend into the first washing tank 36 from its open top, and the tank wall and/or the tank bottom of the first washing tank 36 may be provided with a liquid outlet for discharging the washing liquid. Alternatively, the liquid outlet may be arranged vertically or obliquely.
The controller 80 may be connected to the first moving member 32 and the third liquid path supporting mechanism, and the controller 80 may control the first moving member 32 to drive the sample needle 31 to move to the first container 33, and control the third liquid path supporting mechanism to provide the sucking power for the sample needle 31, so as to suck the strongly oxidizing cleaning solution from the first container 33 through the sample needle 31; controlling the first moving part 32 to drive the sample needle 31 to move from the first container 33 to the first cleaning pool 36, and controlling the third liquid path supporting mechanism to provide discharging power for the sample needle 31 so that the sample needle 31 discharges at least part of the sucked strong oxidizing cleaning liquid to the first cleaning pool 36; the sample needle 31 is controlled to be inserted into the first washing tank 36 to wash the sample needle 31 by the strong oxidizing washing liquid.
The two operations of controlling the sample needle 31 to discharge the strongly oxidizing cleaning liquid into the first cleaning reservoir 36 and controlling the sample needle 31 to be inserted into the first cleaning reservoir 36 may be performed simultaneously, for example, controlling the sample needle 31 to discharge the strongly oxidizing cleaning liquid into the first cleaning reservoir 36 while controlling the sample needle 31 to be inserted into the first cleaning reservoir 36. These two operations may be performed stepwise, for example, by controlling the sample needle 31 to discharge the strongly oxidizing cleaning liquid to the first cleaning bath 36 and then inserting the sample needle 31 into the first cleaning bath 36. In fact, the sample needle 31 has achieved to some extent that the inner wall of the sample needle 31 is cleaned during the suction of the strongly oxidizing cleaning liquid, and the insertion of the sample needle 31 into the strongly oxidizing cleaning liquid in the first cleaning tank 36 at least cleans the outer wall of the sample needle 31 to effectively clean the inner and outer walls of the sample needle 31 from contaminants.
Alternatively, the controller 80 is configured as the controller 80 including a processor and a storage medium storing a computer program. Specifically, the controller 80 includes at least a processing component, a RAM, a ROM, a communication interface, a memory, and an I/O interface. The processing components, RAM, ROM, communications interfaces, memory, and I/O interfaces communicate over a bus. The processing component may be a CPU, GPU or other chip with computing capabilities. The memory stores various computer programs such as an operating system and application programs for execution by the processor element and data required for execution of the computer programs. In addition, during sample analysis, data stored locally may be stored in memory if needed. The I/O interface is constituted by a serial interface such as USB, IEEE or RS-C, a parallel interface such as SCSI, IDE or IEEE, and an analog signal interface composed of a D/a converter, an a/D converter, and the like. An input device consisting of a keyboard, mouse, touch screen or other control buttons is connected to the I/O interface, and a user can directly input data to the controller 80 using the input device. In addition, a display device having a display function, for example, may be connected to the I/O interface: liquid crystal screens, touch screens, LED display screens, and the like. The controller 80 may output the processed data as image display data to a display device for display, for example: analytical data, instrument operating parameters, etc. The communication interface is an interface that may be any communication protocol presently known. The communication interface communicates with the outside through a network. The controller 80 may communicate data with any device connected via the network via a communication interface in a communication protocol.
In a specific implementation, the sample analyzer may further include a detection device 40, where the detection device 40 is used to test the reaction solution to obtain a test result. For example, the detection device 40 may measure the luminescence intensity of the reaction solution, and calculate the concentration of the component to be measured in the sample from the calibration curve.
The sample analyzer of the embodiment of the present invention is provided with the first container 33 for containing the strong oxidizing cleaning liquid, when the sample needle 31 needs to be cleaned, the first moving member 32 is controlled by the controller 80 to drive the sample needle 31 from the strong oxidizing cleaning liquid in the western region of the first container 33, and the strong oxidizing cleaning liquid is discharged into the first cleaning tank 36, and then the sample needle 31 is inserted into the first cleaning tank 36 to clean the sample needle 31 by the strong oxidizing cleaning liquid, so that the samples stained on the inner wall and the outer wall of the sample needle 31 can be cleaned, poor pollution is avoided, and particularly, the sample analyzer has an excellent cleaning effect on fibrin in the sample.
In some embodiments, the sample analyzer further comprises a first fluid path support mechanism for providing wash water to the first wash tank 36; the controller 80 is further configured to:
The first liquid path support mechanism is controlled to supply the cleaning water to the first cleaning tank 36 before the sample needle 31 discharges the strongly oxidizing cleaning liquid in the cleaning tank, and the cleaning water is mixed with the strongly oxidizing cleaning liquid after the sample needle 31 discharges the strongly oxidizing cleaning liquid in the cleaning tank.
Alternatively, the strongly oxidizing cleaning liquid contained in the first container 33 may be a cleaning liquid having a higher concentration of the strong oxidizing agent. The controller 80 controls the first liquid path support mechanism to supply the washing water to the first washing tub 36 before controlling the third liquid path support mechanism to supply the liquid discharge power to the sample needle 31. Then, the third liquid path support mechanism is controlled to supply liquid discharge power to the sample needle 31, and the strongly oxidizing cleaning liquid is discharged through the sample needle 31 into the first cleaning tank 36 containing the cleaning water. The washing water and the strong oxidizing washing liquid are mixed in the first washing tank 36, and the strong oxidizing washing liquid is diluted to a concentration having a preferable washing effect. Then, the first moving member 32 is controlled to drive the sample needle 31 to be inserted into the first cleaning tank 36, and the diluted strong oxidizing cleaning liquid is used for cleaning the sample needle 31, so that a good cleaning effect can be achieved, and the liquid amount of the strong oxidizing cleaning liquid required by single cleaning can be reduced due to the high concentration of the strong oxidizing agent in the strong oxidizing cleaning liquid, so that the liquid amount of the single liquid suction of the sample needle 31 is reduced, the liquid storage amount of the first container 33 is reduced, and the energy consumption is reduced, and meanwhile, the miniaturization of the sample analyzer is also facilitated.
Alternatively, the first liquid path supporting mechanism (not shown) may be a liquid path supporting mechanism connected to the first washing tub 36, and in this case, the first liquid path supporting mechanism may directly inject washing water into the first washing tub 36. Specifically, the first liquid path supporting mechanism may include a driving pump, an electric control valve, and a cleaning water container for containing cleaning water, a tank wall of the first cleaning tank 36 may be provided with a liquid inlet obliquely downward, the driving pump may be connected to the liquid inlet by a capacitance method, and the driving pump may be connected to the cleaning water container by the electric control valve. The electric control valve is used for switching the connecting passage of the driving pump. The driving pump is used to suck the washing water from the washing water container and to inject the washing water into the first washing tub 36 through the liquid inlet.
Alternatively, the third liquid path supporting mechanism may supply the washing water to the sample needle 31 and the washing water may be injected to the first washing tub 36 through the sample needle. Upon injecting the washing water into the first washing tub 36 using the third liquid path supporting mechanism, the controller 80 may be configured to:
controlling the third liquid path supporting mechanism to inject the washing water to the first washing tub 36 through the sample needle 31;
the first moving part 32 is controlled to drive the sample needle 31 to move to the first accommodating position, the third liquid path supporting mechanism is controlled to provide liquid suction power for the sample needle 31, and the strongly oxidizing cleaning liquid is sucked from the first container 33 through the sample needle 31;
Controlling the first moving member 32 to move the sample needle 31 to the first washing reservoir 36, controlling the third liquid path supporting mechanism to supply liquid discharging power to the sample needle 31, discharging at least part of the strongly oxidizing washing liquid sucked by the sample needle 31 into the first washing reservoir 36, so that the washing water and the strongly oxidizing washing liquid are mixed in the first washing reservoir 36;
the first moving member 32 is controlled to drive the sample needle 31 downward to insert the sample needle 31 into the first washing tank 36, and the diluted strong oxidizing washing liquid washes the sample needle 31.
In this way, it is beneficial to simplify the construction of the pipetting system. Of course, in the specific implementation, the first cleaning tank 36 may be supplied with the cleaning water in various manners as long as the purpose of diluting the strongly oxidizing cleaning liquid can be achieved.
In some embodiments, the sample analyzer may further include an ultrasonic assembly 37, and the controller 80 is specifically configured to:
controlling the sample needle 31 to discharge the sucked portion of the strong oxidizing cleaning liquid to the first cleaning reservoir 36, and retaining the portion of the strong oxidizing cleaning liquid in the cavity of the sample needle 31;
controlling the insertion of the sample needle 31 into the first washing bath 36;
the ultrasonic assembly 37 is controlled to provide ultrasonic vibration to the diluted strong oxidizing cleaning liquid in the first cleaning bath 36 to ultrasonically clean the inner and outer walls of the sample needle 31.
For example, the sample needle 31 may have a first section in which the inner wall contacts the sample at the time of sucking and discharging the sample, and a second section in which the outer wall contacts the sample at the time of sucking and discharging the sample. When the strongly oxidizing cleaning liquid is sucked, the liquid suction amount of the sample needle 31 can be controlled to be larger than the liquid amount which can be accommodated in the first stage, and the sample needle 31 is controlled to discharge the sucked part of the strongly oxidizing cleaning liquid to the first cleaning reservoir 36, and at least the first stage of the sample needle 31 accommodates the strongly oxidizing cleaning liquid. The sample needle 31 is controlled to be inserted into the first washing bath 36 and at least the second stage is immersed in the diluted strong oxidizing washing liquid. The ultrasonic assembly 37 is controlled to provide ultrasonic vibration to the diluted strong oxidizing cleaning liquid in the first cleaning bath 36, and the outer wall of the second section is cleaned by the diluted strong oxidizing cleaning liquid in the first cleaning bath 36, and the ultrasonic vibration is transmitted to the strong oxidizing cleaning liquid contained in the first section to ultrasonically clean the inner wall of the first section. The ultrasonic wave has shorter wavelength and better anisotropism, and can obviously improve the cleaning effect.
Alternatively, the ultrasonic assembly 37 may be coupled to the first cleaning tank 36 for applying ultrasonic vibrations to the diluted highly oxidizing cleaning solution through the first cleaning tank 36. The ultrasonic assembly 37 may include an ultrasonic transducer and a transfer member 39, the ultrasonic transducer may be coupled to a first end of the transfer member 39 to be capable of applying ultrasonic vibrations to the transfer member 39 through the first end of the transfer member 39, and a second end of the transfer member 39 is abutted against an outer wall of the first cleaning tank 36 to transfer the ultrasonic vibrations to the first cleaning tank 36 through the second end. Further, the ultrasonic assembly 37 may be disposed at the bottom of the first cleaning tank 36, the second end of the transmitting member 39 may be abutted against the bottom of the first cleaning tank 36, and the ultrasonic transducer 38 may be used to apply ultrasonic vibration to the transmitting member 39 along the vertical direction, so as to drive the diluted cleaning liquid to vibrate along the vertical direction, as shown in fig. 5.
The specific structure and connection of the ultrasonic module 37 are merely exemplary, and the structure and connection of the ultrasonic module 37 should not be construed as limiting, and the ultrasonic module 37 may be disposed laterally of the first cleaning tank 36, or the ultrasonic module 37 may apply vibration to the diluted strongly oxidizing cleaning liquid in the first cleaning tank 36 by other means such as the sample needle 31.
In some embodiments, the sample analyzer further comprises a second washing tank located on a moving track of the sample needle 31, and a second liquid path support mechanism for providing washing water to the second washing tank, the controller 80 is further configured to:
the first moving member 32 is controlled to drive the sample needle 31 to move to the second washing tank, and the second liquid path supporting mechanism is controlled to supply washing water to wash the sample needle 31.
After the sample needle 31 is washed with the strongly oxidizing washing liquid, the sample needle 31 is washed with washing water, and the strongly oxidizing washing liquid stained on the sample needle 31 can be washed, so that the influence of the strongly oxidizing washing liquid on the subsequent detection result can be avoided. Optionally, the second cleaning tank may be an open-top container, and a liquid outlet may be provided on a tank wall and/or a tank bottom of the second cleaning tank to enable the cleaning water to be discharged. The second liquid path supporting mechanism may be connected to the second washing tank, for example, a liquid inlet disposed obliquely downward may be provided on a tank wall of the second washing tank, and the second liquid path supporting mechanism may supply washing water to the second washing tank through the liquid inlet and wash the sample needle 31 inserted into the washing tank through the washing water. Alternatively, the second liquid path supporting mechanism may include a driving pump, an electric control valve, and a washing water container for containing washing water, the driving pump may be connected to the liquid inlet of the second washing tank and the washing water container, respectively, through the electric control valve, and the connection path of the driving pump may be switched by the electric control valve, and the washing water may be sucked from the washing water container through the driving pump and transferred to the second washing tank.
Optionally, the controller 80 may be further configured to: the third liquid path supporting mechanism is controlled to supply the washing water to the sample needle 31 and drain the washing water to the second washing tank through the sample needle 31 to wash the inner wall of the sample needle 31. In this way, not only the outer wall of the sample needle 31 but also the inner wall of the sample needle 31 can be flushed. In the specific implementation, the control of the second liquid path supporting mechanism to provide the cleaning water and the control of the third liquid path supporting mechanism to provide the cleaning tank can be performed synchronously or stepwise.
In some embodiments, the controller 80 is further configured to:
controlling the sample needle 31 to move to the reaction position;
the sample needle 31 is controlled to discharge a strong oxidizing cleaning liquid to the cuvette 22 to clean the cuvette 22 by the strong oxidizing cleaning liquid.
For sample analyst to test, the sample needs to be incubated in the cuvette 22 as a reaction solution, so the cuvette 22 is also contaminated with the sample. The reaction cuvette 22 is cleaned by the strongly oxidizing cleaning liquid, and substances such as fibrin and the like which are adhered to the reaction cuvette 22 can be cleaned. Alternatively, the controller 80 may control the reaction disk 21 to rotate the cuvette 22 to be cleaned onto the moving track of the sample needle 31. The third liquid path supporting mechanism is controlled to supply liquid discharging power to the sample needle 31 so as to discharge the strongly oxidizing cleaning liquid sucked by the sample needle 31 into the cuvette 22 to be cleaned, and the cuvette 22 is cleaned by the strongly oxidizing cleaning liquid.
When the reaction cup 22 is cleaned by the strong oxidizing cleaning liquid, cleaning water can be injected into the reaction cup 22 to dilute the strong oxidizing cleaning liquid, and the diluted strong oxidizing cleaning liquid is used for cleaning the reaction cup 22 so as to obtain a better cleaning effect. In practice, the rinse water may be injected into the cuvette 22 in a variety of ways.
In some embodiments, the controller 80 is further configured to:
the third liquid path supporting means is controlled to inject the cleaning water into the cuvette 22 through the sample needle 31 to dilute the strongly oxidizing cleaning liquid, and to clean the cuvette 22 by the diluted strongly oxidizing cleaning liquid.
Alternatively, before controlling the sample needle 31 to suck the strongly oxidizing cleaning liquid from the first container 33, the first moving member 32 may be controlled to move the sample needle 31 to the sample position, and the third liquid path supporting mechanism may be controlled to inject the cleaning water into the cuvette 22 through the sample needle 31. Then, the first moving part 32 is controlled to drive the sample needle 31 to move to the first container 33, so that the sample needle 31 sucks the strong oxidizing cleaning agent from the first container 33, and the first moving part 32 is controlled to drive the sample needle 31 to move to the sample position, so that the sample needle 31 discharges the strong oxidizing cleaning agent into the reaction cup 22. Alternatively, the sample needle 31 may be controlled to discharge the strongly oxidizing cleaning liquid into the cuvette 22, and then the third liquid path supporting means may be controlled to inject the cleaning liquid into the cuvette 22 through the sample needle 31 to dilute the strongly oxidizing cleaning liquid. The injection of the washing water into the cuvette 22 through the sample needle 31 is advantageous not only in simplifying the structure of the liquid path system but also in simplifying the operation process and improving the washing efficiency.
In some embodiments, the sample analyzer further comprises: a reagent carrying mechanism 50, a reagent dispensing mechanism 60, a third washing bath 63, and a fourth liquid path supporting mechanism.
The reagent carrier 50 is provided with at least one reagent site for placing a reagent container for holding a reagent. Alternatively, the reagent carrying mechanism 50 may comprise, for example, a reagent disk, which may have a disk shape with a plurality of positions for carrying reagent containers, and the reagent carrying mechanism 50 may be capable of rotating and driving the reagent containers carried thereby to rotate the reagent containers to a specific position, for example, a position where reagent is sucked by the reagent dispensing mechanism 60. The number of reagent carrying mechanisms 50 may be one or more.
The reagent dispensing mechanism 60 includes a second moving member 61 and a reagent needle 62 provided on the second moving member 61, the second moving member 61 being configured to drive the reagent needle 62 to move between the reagent position and the placement position, and to aspirate a reagent at the reagent position through the reagent needle 62 and discharge the reagent at the placement position, so that the sample and the reagent in the cuvette 22 are mixed to form the reaction solution.
The third washing bath 63 is provided on the moving track of the reagent needle 62. The third wash tank 63 may be a wash tank dedicated to washing the reagent needles 62. The fourth liquid path supporting mechanism is for supplying the third washing tub 63 with washing water. Alternatively, the third cleaning tank 63 may be provided with a liquid inlet, and the fourth liquid path supporting mechanism may supply cleaning water to the third cleaning tank 63 through the liquid inlet of the third cleaning tank 63. Alternatively, the specific structure of the fourth liquid path support mechanism may be similar to the first liquid path support mechanism and the second liquid path support mechanism, or may be different from the first liquid path support mechanism and the second liquid path support mechanism, as long as the third cleaning tank 63 can be supplied with cleaning water, and the specific structure thereof is not limited herein.
The controller 80 is further configured to: controlling the fourth liquid path supporting mechanism to inject the washing water into the third washing tub 63; controlling the second moving part 61 to drive the reagent needle 62 to move to the third washing tub 63, and sucking washing water from the third washing tub 63 through the reagent needle 62; the reagent needle 62 is controlled to inject the cleaning water into the cuvette 22 to dilute the strongly oxidizing cleaning solution, and the diluted strongly oxidizing cleaning solution is used to clean the cuvette 22.
That is, the reagent needle 62 may be used to inject the cleaning water into the cuvette 22, and the sample needle 31 and the reagent needle 62 may be used to inject the strongly oxidizing cleaning liquid and the cleaning water into the cuvette 22, respectively, so that both mechanisms can be performed simultaneously, which is advantageous in improving the cleaning efficiency and shortening the cleaning time. Optionally, before controlling the sample needle 31 to inject the strong oxidizing cleaning solution into the reaction cup 22, the reagent needle 62 may be controlled to inject the cleaning water into the reaction cup 22, and then, the sample needle 31 is controlled to inject the strong oxidizing cleaning solution into the reaction cup 22, and then, the reagent needle 62 is controlled to inject the cleaning water into the reaction cup 22 again until the strong oxidizing cleaning solution is diluted to a preferred concentration, so as to obtain a better cleaning effect.
In some embodiments, the sample analyzer further comprises:
the mixing device 70, the mixing device 70 includes a third moving mechanism 71, a driving mechanism, and a mixing rod 72 disposed on the third moving mechanism 71, the third moving mechanism 71 is configured to drive the mixing rod 72 to move between the placement position and the reaction position, and the driving mechanism is configured to drive the mixing rod 72 to perform a stirring operation:
the controller 80 is further configured to:
The third moving mechanism 71 is controlled to move the mixing rod 72 to the reaction position, and the driving mechanism is controlled to drive the mixing rod 72 to stir the diluted strong oxidizing cleaning solution in the reaction cup 22, so that the mixing rod 72 and the reaction cup 22 are cleaned by the diluted strong oxidizing cleaning solution.
Alternatively, the mixing device 70 may be a sample mixing device 70 for mixing a sample, or may be a reagent mixing device 70 for mixing a reagent added to the cuvette 22. The diluted strong-oxidizing cleaning solution in the reaction cup 22 is stirred by the mixing rod 72, so that the inner wall of the reaction cup 22 can be well cleaned, and the aim of cleaning the mixing rod 72 can be fulfilled. Alternatively, the sample mixing rod 72 of the sample mixing device 70 may be controlled to stir the diluted strong oxidizing cleaning solution in the reaction cup 22, and the reagent mixing rod 72 of the reagent mixing device 70 may be controlled to stir the diluted strong oxidizing cleaning solution in the reaction cup 22, so that the diluted strong oxidizing cleaning solution is used to clean the sample mixing rod 72 and the reagent mixing rod 72 respectively.
The sample needle 31, the cuvette 22, and the mixing rod 72 may be washed with a strong oxidizing washing liquid or a diluted strong oxidizing washing liquid, and then transferred to another washing tank, and washed with, for example, washing water or another type of washing agent, or subjected to ultrasonic washing. For example, after the stirring of the mixing rod 72 in the reaction tank is completed, the mixing rod 72 can be driven to other cleaning tanks by the third moving part, and the base cleaning agent and the cleaning water are used for cleaning the mixing rod 72 respectively.
In some embodiments, the controller 80 is further configured to:
in the case where the sample needle 31 performs a preset number of operations for the first time, or in the case where the cumulative length of time for which the sample analyzer performs the detection operation reaches a preset length of time, controlling the sample needle 31 to suck the strong oxidizing cleaning liquid from the first container 33, performing the cleaning of the object to be cleaned for the second time by the strong oxidizing cleaning liquid;
wherein the object to be cleaned is the sample needle 31, the reagent needle 62, the cuvette 22 or the mixing rod 72.
Alternatively, the sample needle 31 may be cleaned with a strong oxidizing cleaning fluid after each test is completed. Specifically, the controller 80 may control the first moving member 32 to drive the sample needle 31 to move to the first container 33, so that the sample needle 31 sucks the strongly oxidizing cleaning solution from the first container 33, and controls the sample needle 31 to discharge the strongly oxidizing cleaning solution into the first cleaning pool 36, so as to achieve the purpose of cleaning the inner wall of the sample needle 31 with the strongly oxidizing cleaning solution. After each batch of test is completed, the inner wall of the sample needle 31 may be cleaned only once with a strong oxidizing cleaning liquid, and of course, may be cleaned a plurality of times. It should be noted that each test described herein is not limited to only one sample at a time, and a plurality of samples may be tested, and thus each test completion should be understood as each batch test completion.
Alternatively, after the completion of the plurality of tests, the sample needle 31 may be controlled to suck the strongly oxidizing cleaning liquid from the first container 33, and the strongly oxidizing cleaning liquid may be discharged into the first cleaning tank 36, and repeatedly sucked and discharged a plurality of times to clean the inner wall of the sample needle 31 a plurality of times with the strongly oxidizing cleaning liquid. For example, after performing multiple batches of tests, sample needle 31 may be washed three times with a strong oxidizing cleaning solution.
Alternatively, in the case where the cumulative time period during which the sample analyzer performs the detection operation reaches the preset time period, the sample needle 31 may be controlled to suck the strongly oxidizing cleaning liquid from the first container 33 to clean one or more of the sample needle 31, the cuvette 22, or the mixing rod 72. For example, a daily washing operation of nine washing cycles may be performed on the sample needle 31, the cuvette 22, and the mixing rod 72 every day. Specifically, the controllable reagent needle 62 sucks the washing water from the third washing tank 63 and discharges the washing water into the reaction cup 22; controlling the sample needle 31 to suck the strongly oxidizing cleaning liquid from the first container 33 and discharging the strongly oxidizing cleaning liquid into the cuvette 22 through the sample needle 31; the control reagent needle 62 again sucks the washing water from the third washing tank 63 and injects the washing water again into the reaction cup 22 until the strongly oxidizing washing liquid is diluted to a preferable concentration; the sample mixing rod piece 72 is controlled to stir the diluted strong-oxidizing cleaning liquid in the reaction cup 22 so as to clean the sample mixing rod piece 72 and the reaction cup 22, and then the sample mixing rod piece 72 is moved to other cleaning tanks to be cleaned by using cleaning water and a base cleaning agent; the reagent mixing rod 72 is controlled to stir the diluted strong oxidizing cleaning liquid in the reaction cup 22 to clean the reagent mixing rod 72 and the reaction cup 22, and then the reagent mixing rod 72 is moved to other cleaning tanks to clean by using the cleaning water and the base cleaning agent. So far, one cleaning cycle is completed, and nine cleaning cycles are repeatedly executed in the daily cleaning operation process.
Alternatively, periodic cleaning operations may also be performed weekly. For example, the periodic cleaning operation may include two hundred six cleaning cycles. The cleaning cycle in the weekly cleaning operation is substantially the same as the specific process in the daily cleaning operation, and will not be described here.
In some embodiments, the sample analyzer further comprises: a second container 34 in which a strongly acidic cleaning solution is contained, the second container 34 being positioned on the movement locus of the sample needle 31: the controller 80 is further configured to:
controlling the first moving mechanism to drive the sample needle 31 to suck the strongly acidic cleaning liquid in the second container 34;
controlling the sample needle 31 to discharge a strongly acidic cleaning solution in the cleaning bath;
the sample needle 31 is controlled to be inserted into the washing bath so as to wash the sample needle 31 by the strongly acidic washing liquid.
Alternatively, the strongly acidic cleaning solution may be a cleaning solution containing a strong acid. In this way, the sample analyzer can clean not only the sample needle 31 with the strongly oxidizing cleaning liquid, but also the sample needle 31 with the strongly acidic cleaning liquid. The strongly acidic cleaning solution has a better cleaning effect on ionic substances, so that the sample needle 31 is thoroughly cleaned.
In some embodiments, the sample analyzer further comprises: a third container 35 in which a strongly alkaline cleaning liquid is contained, the third container 35 being located on the movement locus of the sample needle 31; the controller 80 is further configured to:
controlling the first moving mechanism to drive the sample needle 31 to suck the strong alkaline cleaning liquid in the third container 35;
controlling the sample needle 31 to discharge a strongly oxidizing cleaning liquid in the cleaning bath;
the sample needle 31 is controlled to be inserted into the washing bath so that the sample needle 31 is washed by the strongly alkaline washing liquid.
Alternatively, the strongly alkaline cleaning solution may be a cleaning solution containing a strong base or a solution containing other strongly alkaline substances. The strong alkaline cleaner has a good cleaning effect on the lipid substances, and thus, the cleaning effect of the sample needle 31 can be further improved.
Optionally, in a specific implementation, the sample analyzer may be provided with the first container 33, the second container 34 and the third container 35 at the same time, and when the sample needle 31, the reaction cup 22 or the mixing rod 72 needs to be cleaned, firstly, the sample analyzer may be cleaned by a strong acid cleaning solution, then, the sample analyzer may be cleaned by a strong alkaline cleaning solution, and finally, the sample analyzer may be cleaned by a strong oxidizing cleaning solution, so as to respectively clean out ionic substances, lipid substances and protein substances, thereby achieving a better cleaning effect.
The embodiment of the invention also provides a cleaning method which is applied to the sample analyzer, and the sample analyzer can comprise a sample bearing mechanism, a reaction mechanism, a sample dispensing mechanism, a first container and a first cleaning pool.
Referring to fig. 6, the cleaning method according to the embodiment of the present invention may specifically include the following steps:
step 1, controlling a first moving part to drive a sample needle to suck a strong-oxidizing cleaning liquid in a first container;
step 2, controlling the sample needle to discharge strong-oxidizing cleaning liquid in the cleaning pool;
and 3, controlling the sample needle to be inserted into the cleaning pool so as to clean the sample needle through the strong oxidizing cleaning liquid.
According to the cleaning method disclosed by the embodiment of the invention, when the sample needle needs to be cleaned, the first moving part is controlled by the controller to drive the sample needle to be cleaned from the western region strong oxidizing cleaning liquid in the first container, the strong oxidizing cleaning liquid is discharged into the first cleaning tank, and then the sample needle is inserted into the first cleaning tank so as to clean the sample needle through the strong oxidizing cleaning liquid, so that the contaminated sample on the sample needle can be cleaned, poor pollution is avoided, and particularly, the cleaning effect on fibrin in the sample is excellent.
The steps 1, 2 and 3 are not absolutely sequential, as long as the purpose of cleaning the sample needle with the strongly oxidizing cleaning liquid can be achieved.
In some embodiments, the cleaning method further comprises:
controlling the sample needle to move to the reaction position;
and controlling the sample needle to discharge the strong oxidizing cleaning liquid to the reaction cup so as to clean the reaction cup through the strong oxidizing cleaning liquid.
In some embodiments, the control method further comprises:
the first liquid path support mechanism is controlled to supply the cleaning water to the first cleaning tank before the sample needle discharges the strongly oxidizing cleaning liquid in the first cleaning tank, and the cleaning water is mixed with the strongly oxidizing cleaning liquid after the sample needle discharges the strongly oxidizing cleaning liquid in the first cleaning tank.
In some embodiments, the control method further comprises:
controlling the sample needle to discharge the sucked part of the strong oxidizing cleaning liquid to the first cleaning tank, and retaining the part of the strong oxidizing cleaning liquid in the cavity of the sample needle;
controlling the sample needle to be inserted into the first cleaning pool;
And controlling the ultrasonic assembly to provide ultrasonic vibration for the diluted strong-oxidizing cleaning liquid in the first cleaning pool so as to clean the inner wall and the outer wall of the sample needle in an ultrasonic manner.
In some embodiments, the control method further comprises:
controlling the first moving part to drive the sample needle to move to the second cleaning pool, and controlling the second liquid path supporting mechanism to provide cleaning water for flushing the sample needle.
In some embodiments, the control method further comprises:
controlling the sample needle to move to the reaction position;
and controlling the sample needle to discharge the strong oxidizing cleaning liquid to the reaction cup so as to clean the reaction cup through the strong oxidizing cleaning liquid.
In some embodiments, the control method further comprises:
and controlling the third liquid path supporting mechanism to inject cleaning water into the reaction cup through the sample needle so as to dilute the strong oxidizing cleaning liquid, and cleaning the reaction cup through the diluted strong oxidizing cleaning liquid.
In some embodiments, the control method further comprises:
controlling the fourth liquid path supporting mechanism to inject cleaning water into the third cleaning tank;
Controlling the second moving part to drive the reagent needle to move to the third washing tank, and sucking washing water from the third washing tank through the reagent needle;
and controlling the reagent needle to inject cleaning water into the reaction cup so as to dilute the strong oxidizing cleaning liquid, and cleaning the reaction cup through the diluted strong oxidizing cleaning liquid.
In some embodiments, the control method further comprises:
and controlling the third moving mechanism to move the mixing rod piece to the reaction position, and controlling the driving mechanism to drive the mixing rod piece to stir the diluted strong-oxidizing cleaning liquid in the reaction cup so as to clean the mixing rod piece and the reaction cup through the diluted strong-oxidizing cleaning liquid.
In some embodiments, the control method further comprises:
controlling the first moving mechanism to drive the sample needle to suck the strongly acidic cleaning solution in the second container;
controlling the sample needle to discharge a strong acid cleaning solution in the cleaning tank;
controlling the sample needle to be inserted into the cleaning pool so as to clean the sample needle through the strongly acidic cleaning liquid;
and/or
The sample analyzer further comprises:
A third container containing a strongly alkaline cleaning solution, the third container being located on the locus of movement of the sample needle;
the controller is further configured to:
controlling the first moving mechanism to drive the sample needle to suck the strong alkaline cleaning liquid in the third container;
controlling the sample needle to discharge the strong alkaline cleaning liquid in the cleaning pool;
controlling the sample needle to be inserted into the cleaning pool so as to clean the sample needle through the strong alkaline cleaning liquid.
In some embodiments, the control method further comprises:
under the condition that the sample needle executes the preset operation of the first time or the accumulated time length of the sample analyzer executing the detection operation reaches the preset time length, controlling the sample needle to absorb the strong oxidizing cleaning liquid from the first container, and executing the cleaning of the object to be cleaned for the second time through the strong oxidizing cleaning liquid;
wherein the object to be cleaned is the sample needle, the reaction cup or the uniformly mixed rod piece.
The above embodiments are only exemplary embodiments of the present invention and are not intended to limit the present invention, the scope of which is defined by the claims. Various modifications and equivalent arrangements of this invention will occur to those skilled in the art, and are intended to be within the spirit and scope of the invention.

Claims (14)

1. A sample analyzer, comprising:
a sample carrier provided with at least one sample site for placing a sample container for holding a sample;
the reaction mechanism comprises at least one placement position, wherein the placement position is used for placing a reaction cup and incubating a reaction liquid in the reaction cup, and the reaction liquid is formed by the sample;
a sample dispensing mechanism including a first moving member and a sample needle provided on the first moving member; the first moving part is used for driving the sample needle to move between the sample position and the placement position so as to suck the sample at the sample position and discharge the sample at the placement position through the sample needle;
a first container containing a strongly oxidizing cleaning liquid, the first container being located on the locus of movement of the sample needle;
a first washing tank located on a moving track of the sample needle;
a controller configured to:
controlling the first moving part to drive the sample needle to suck the strongly oxidizing cleaning liquid in the first container;
Controlling the sample needle to discharge a strongly oxidizing cleaning liquid in the first cleaning tank;
controlling the sample needle to be inserted into a first cleaning pool so as to clean the sample needle through the strong oxidizing cleaning liquid.
2. The sample analyzer of claim 1, further comprising a first fluid path support mechanism for providing wash water to the first wash tank; the controller is further configured to:
the first liquid path support mechanism is controlled to supply the cleaning water to the first cleaning tank before the sample needle discharges the strongly oxidizing cleaning liquid in the first cleaning tank, and the cleaning water is mixed with the strongly oxidizing cleaning liquid after the sample needle discharges the strongly oxidizing cleaning liquid in the first cleaning tank.
3. The sample analyzer of claim 2, further comprising an ultrasonic assembly, the controller being specifically configured to:
controlling the sample needle to discharge the sucked part of the strong oxidizing cleaning liquid to the first cleaning tank, and retaining the part of the strong oxidizing cleaning liquid in the cavity of the sample needle;
controlling the sample needle to be inserted into the first cleaning pool;
And controlling the ultrasonic assembly to provide ultrasonic vibration for the diluted strong-oxidizing cleaning liquid in the first cleaning pool so as to clean the inner wall and the outer wall of the sample needle in an ultrasonic manner.
4. The sample analyzer of claim 3, further comprising a second wash tank positioned on a movement trajectory of the sample needle, and a second fluid path support mechanism to provide wash water to the second wash tank, the controller further configured to:
controlling the first moving part to drive the sample needle to move to the second cleaning pool, and controlling the second liquid path supporting mechanism to provide cleaning water for flushing the sample needle.
5. The sample analyzer of claim 1, wherein the controller is further configured to:
controlling the sample needle to move to the reaction position;
and controlling the sample needle to discharge the strong oxidizing cleaning liquid to the reaction cup so as to clean the reaction cup through the strong oxidizing cleaning liquid.
6. The sample analyzer of claim 5, wherein the sample dispensing mechanism further comprises a third fluid path support mechanism for providing motive force for aspiration and expulsion of the sample needle and for providing wash water to the sample needle; the controller is further configured to:
And controlling the third liquid path supporting mechanism to inject cleaning water into the reaction cup through the sample needle so as to dilute the strong oxidizing cleaning liquid, and cleaning the reaction cup through the diluted strong oxidizing cleaning liquid.
7. The sample analyzer of claim 5, further comprising:
the reagent carrying mechanism is provided with at least one reagent position, the reagent position is used for placing a reagent container, and the reagent container is used for containing a reagent;
a reagent dispensing mechanism including a second moving member and a reagent needle provided on the second moving member, the second moving member being configured to drive the reagent needle to move between the reagent position and the placement position, aspirate a reagent at the reagent position through the reagent needle and discharge a reagent at the placement position so that a sample and a reagent in the reaction cup are mixed to form the reaction liquid;
the third cleaning pool is arranged on the moving track of the reagent needle;
a fourth liquid path support mechanism for providing washing water to the third washing tank;
The controller is further configured to:
controlling the fourth liquid path supporting mechanism to inject cleaning water into the third cleaning tank;
controlling the second moving part to drive the reagent needle to move to the third washing tank, and sucking washing water from the third washing tank through the reagent needle;
and controlling the reagent needle to inject cleaning water into the reaction cup so as to dilute the strong oxidizing cleaning liquid, and cleaning the reaction cup through the diluted strong oxidizing cleaning liquid.
8. The sample analyzer of claim 7, further comprising:
the mixing device comprises a third moving mechanism, a driving mechanism and a mixing rod piece arranged on the third moving mechanism, wherein the third moving mechanism is used for driving the mixing rod piece to move between the placing position and the reaction position, and the driving mechanism is used for driving the mixing rod piece to perform stirring operation:
the controller is further configured to:
and controlling the third moving mechanism to move the mixing rod piece to the reaction position, and controlling the driving mechanism to drive the mixing rod piece to stir the diluted strong-oxidizing cleaning liquid in the reaction cup so as to clean the mixing rod piece and the reaction cup through the diluted strong-oxidizing cleaning liquid.
9. The sample analyzer according to claim 1, wherein the sample analyzer includes a plurality of the sample dispensing mechanisms, and the first containers are provided on a moving locus of the sample needle of each of the sample dispensing mechanisms.
10. The sample analyzer of claim 1, further comprising:
the second container is filled with a strongly acidic cleaning solution and is positioned on the moving track of the sample needle:
the controller is further configured to:
controlling the first moving mechanism to drive the sample needle to suck the strongly acidic cleaning solution in the second container;
controlling the sample needle to discharge a strong acid cleaning solution in the cleaning tank;
controlling the sample needle to be inserted into the cleaning pool so as to clean the sample needle through the strongly acidic cleaning liquid;
and/or
The sample analyzer further comprises:
a third container containing a strongly alkaline cleaning solution, the third container being located on the locus of movement of the sample needle;
the controller is further configured to:
controlling the first moving mechanism to drive the sample needle to suck the strong alkaline cleaning liquid in the third container;
Controlling the sample needle to discharge the strongly alkaline cleaning liquid in the cleaning reservoir;
controlling the sample needle to be inserted into the cleaning pool so as to clean the sample needle through the strong alkaline cleaning liquid.
11. The sample analyzer of any one of claims 1 to 8, wherein the controller is further configured to:
and under the condition that the sample needle executes the preset operation of the first time or the accumulated time length of the sample analyzer for executing the detection operation reaches the preset time length, controlling the sample needle to suck the strong oxidizing cleaning liquid from the first container, and executing the cleaning of the sample needle for the second time through the strong oxidizing cleaning liquid.
12. The sample analyzer of claim 1, wherein the strongly oxidizing cleaning fluid is a sodium hypochlorite solution.
13. A cleaning method for a sample analyzer, the cleaning method comprising:
controlling the first moving part to drive the sample needle to suck the strong-oxidizing cleaning liquid in the first container;
controlling the sample needle to discharge a strong oxidizing cleaning liquid in a cleaning pool;
controlling the sample needle to be inserted into the cleaning pool so as to clean the sample needle through the strong oxidizing cleaning liquid.
14. The cleaning method of claim 13, further comprising:
controlling the sample needle to move to a reaction position;
and controlling the sample needle to discharge the strong oxidizing cleaning liquid to the reaction cup so as to clean the reaction cup through the strong oxidizing cleaning liquid.
CN202111477716.7A 2021-12-06 2021-12-06 Sample analyzer and cleaning method Pending CN116223824A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN202111477716.7A CN116223824A (en) 2021-12-06 2021-12-06 Sample analyzer and cleaning method

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN202111477716.7A CN116223824A (en) 2021-12-06 2021-12-06 Sample analyzer and cleaning method

Publications (1)

Publication Number Publication Date
CN116223824A true CN116223824A (en) 2023-06-06

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Family Applications (1)

Application Number Title Priority Date Filing Date
CN202111477716.7A Pending CN116223824A (en) 2021-12-06 2021-12-06 Sample analyzer and cleaning method

Country Status (1)

Country Link
CN (1) CN116223824A (en)

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