CN116209755A - 可编程核酸酶和使用方法 - Google Patents

可编程核酸酶和使用方法 Download PDF

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Publication number
CN116209755A
CN116209755A CN202180056722.7A CN202180056722A CN116209755A CN 116209755 A CN116209755 A CN 116209755A CN 202180056722 A CN202180056722 A CN 202180056722A CN 116209755 A CN116209755 A CN 116209755A
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programmable
nuclease
nucleic acid
casφ
sequence
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Chinese (zh)
Inventor
卢卡斯·本杰明·哈林顿
威廉·道格拉斯·赖特
刘佩琪
本杰明·朱利叶斯·劳奇
维普特拉·贾亚·哈托诺
布里奇特·安·潘恩·麦凯
达努塔·萨斯特雷·菲普斯
郑宇轩
尼雷亚·桑维森斯
肖恩·陈
大卫·佩兹-埃斯皮诺
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Mammoth Biosciences Inc
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Mammoth Biosciences Inc
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CN202180056722.7A 2020-06-03 2021-06-03 可编程核酸酶和使用方法 Pending CN116209755A (zh)

Applications Claiming Priority (17)

Application Number Priority Date Filing Date Title
US202063034346P 2020-06-03 2020-06-03
US63/034,346 2020-06-03
US202063037535P 2020-06-10 2020-06-10
US63/037,535 2020-06-10
US202063040998P 2020-06-18 2020-06-18
US63/040,998 2020-06-18
US202063092481P 2020-10-15 2020-10-15
US63/092,481 2020-10-15
US202063116083P 2020-11-19 2020-11-19
US63/116,083 2020-11-19
US202063124676P 2020-12-11 2020-12-11
US63/124,676 2020-12-11
US202163156883P 2021-03-04 2021-03-04
US63/156,883 2021-03-04
US202163178472P 2021-04-22 2021-04-22
US63/178,472 2021-04-22
PCT/US2021/035781 WO2021247924A1 (en) 2020-06-03 2021-06-03 Programmable nucleases and methods of use

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CN116209755A true CN116209755A (zh) 2023-06-02

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EP (1) EP4162052A4 (https=)
JP (1) JP2023529151A (https=)
CN (1) CN116209755A (https=)
AU (1) AU2021282578A1 (https=)
CA (1) CA3178670A1 (https=)
WO (1) WO2021247924A1 (https=)

Cited By (3)

* Cited by examiner, † Cited by third party
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CN116844639A (zh) * 2023-06-14 2023-10-03 上海诚明融鑫科技有限公司 一种具有自适应学习控制能力的人类mtDNA快速比对方法及装置
CN119351374A (zh) * 2024-12-23 2025-01-24 内蒙古大学 工程化改造超紧凑型CRISPR/Cas12j-8及其应用
CN120330238A (zh) * 2025-04-10 2025-07-18 北京林业大学 一种ect2基因在调控杨树次生木质部发育中的应用

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AU2015330699B2 (en) 2014-10-10 2021-12-02 Editas Medicine, Inc. Compositions and methods for promoting homology directed repair
EP3830301B1 (en) 2018-08-01 2024-05-22 Mammoth Biosciences, Inc. Programmable nuclease compositions and methods of use thereof
US20240026351A1 (en) * 2020-10-30 2024-01-25 Arbor Biotechnologies, Inc. Compositions comprising an rna guide targeting trac and uses thereof
WO2023173110A1 (en) * 2022-03-11 2023-09-14 Epicrispr Biotechnologies, Inc. Compositions, systems, and methods for treating familial hypercholesterolemia by targeting pcsk9
WO2023220654A2 (en) * 2022-05-10 2023-11-16 Mammoth Biosciences, Inc. Effector protein compositions and methods of use thereof
WO2023220649A2 (en) * 2022-05-10 2023-11-16 Mammoth Biosciences, Inc. Effector protein compositions and methods of use thereof
IL317874A (en) 2022-06-24 2025-02-01 Tune Therapeutics Inc Compounds, systems and methods for reducing low density lipoproteins through targeted gene suppression
WO2024047587A1 (en) * 2022-08-31 2024-03-07 Regel Therapeutics, Inc. Cas-phi compositions and methods of use
WO2024073114A1 (en) * 2022-09-30 2024-04-04 Vedabio, Inc. Delivery of therapeutics in vivo via a crispr-based cascade system
WO2024091958A1 (en) * 2022-10-25 2024-05-02 Mammoth Biosciences, Inc. Effector proteins, compositions, systems and methods for the modification of serpina1
WO2024107665A1 (en) * 2022-11-14 2024-05-23 Mammoth Biosciences, Inc. Effector proteins, compositions, systems and methods of use thereof
WO2024127370A1 (en) * 2022-12-16 2024-06-20 LifeEDIT Therapeutics, Inc. Guide rnas that target trac gene and methods of use
EP4637841A1 (en) * 2022-12-22 2025-10-29 Mammoth Biosciences, Inc. Compositions and methods for modifying dux4
EP4673550A2 (en) * 2023-02-27 2026-01-07 Mammoth Biosciences, Inc. Compositions and methods for the modification and regulation of liver gene expression
AU2024236558A1 (en) 2023-03-15 2025-10-09 Renagade Therapeutics Management Inc. Delivery of gene editing systems and methods of use thereof
WO2024238321A1 (en) * 2023-05-12 2024-11-21 Mammoth Biosciences, Inc. Compositions and methods for targeted epigenetic modification
AU2024335327A1 (en) 2023-09-01 2026-03-26 Renagade Therapeutics Management Inc. Gene editing systems, compositions, and methods for treatment of vexas syndrome
WO2025050015A1 (en) * 2023-09-01 2025-03-06 Script Biosciences, Inc. Compositions and methods for targeted modification of msh3
WO2025174765A1 (en) 2024-02-12 2025-08-21 Renagade Therapeutics Management Inc. Lipid nanoparticles comprising coding rna molecules for use in gene editing and as vaccines and therapeutic agents

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Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN116844639A (zh) * 2023-06-14 2023-10-03 上海诚明融鑫科技有限公司 一种具有自适应学习控制能力的人类mtDNA快速比对方法及装置
CN119351374A (zh) * 2024-12-23 2025-01-24 内蒙古大学 工程化改造超紧凑型CRISPR/Cas12j-8及其应用
CN119351374B (zh) * 2024-12-23 2025-03-25 内蒙古大学 工程化改造超紧凑型CRISPR/Cas12j-8及其应用
CN120330238A (zh) * 2025-04-10 2025-07-18 北京林业大学 一种ect2基因在调控杨树次生木质部发育中的应用

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AU2021282578A1 (en) 2023-02-02
EP4162052A4 (en) 2024-07-10
US20230167454A1 (en) 2023-06-01
EP4162052A1 (en) 2023-04-12
US20230357735A1 (en) 2023-11-09
JP2023529151A (ja) 2023-07-07
US20250066797A1 (en) 2025-02-27
CA3178670A1 (en) 2021-12-09

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