AU2021282578A1 - Programmable nucleases and methods of use - Google Patents
Programmable nucleases and methods of use Download PDFInfo
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- AU2021282578A1 AU2021282578A1 AU2021282578A AU2021282578A AU2021282578A1 AU 2021282578 A1 AU2021282578 A1 AU 2021282578A1 AU 2021282578 A AU2021282578 A AU 2021282578A AU 2021282578 A AU2021282578 A AU 2021282578A AU 2021282578 A1 AU2021282578 A1 AU 2021282578A1
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| PCT/US2021/035781 WO2021247924A1 (en) | 2020-06-03 | 2021-06-03 | Programmable nucleases and methods of use |
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| AU2015330699B2 (en) | 2014-10-10 | 2021-12-02 | Editas Medicine, Inc. | Compositions and methods for promoting homology directed repair |
| EP3830301B1 (en) | 2018-08-01 | 2024-05-22 | Mammoth Biosciences, Inc. | Programmable nuclease compositions and methods of use thereof |
| US20240026351A1 (en) * | 2020-10-30 | 2024-01-25 | Arbor Biotechnologies, Inc. | Compositions comprising an rna guide targeting trac and uses thereof |
| WO2023173110A1 (en) * | 2022-03-11 | 2023-09-14 | Epicrispr Biotechnologies, Inc. | Compositions, systems, and methods for treating familial hypercholesterolemia by targeting pcsk9 |
| WO2023220654A2 (en) * | 2022-05-10 | 2023-11-16 | Mammoth Biosciences, Inc. | Effector protein compositions and methods of use thereof |
| WO2023220649A2 (en) * | 2022-05-10 | 2023-11-16 | Mammoth Biosciences, Inc. | Effector protein compositions and methods of use thereof |
| IL317874A (en) | 2022-06-24 | 2025-02-01 | Tune Therapeutics Inc | Compounds, systems and methods for reducing low density lipoproteins through targeted gene suppression |
| WO2024047587A1 (en) * | 2022-08-31 | 2024-03-07 | Regel Therapeutics, Inc. | Cas-phi compositions and methods of use |
| WO2024073114A1 (en) * | 2022-09-30 | 2024-04-04 | Vedabio, Inc. | Delivery of therapeutics in vivo via a crispr-based cascade system |
| WO2024091958A1 (en) * | 2022-10-25 | 2024-05-02 | Mammoth Biosciences, Inc. | Effector proteins, compositions, systems and methods for the modification of serpina1 |
| WO2024107665A1 (en) * | 2022-11-14 | 2024-05-23 | Mammoth Biosciences, Inc. | Effector proteins, compositions, systems and methods of use thereof |
| WO2024127370A1 (en) * | 2022-12-16 | 2024-06-20 | LifeEDIT Therapeutics, Inc. | Guide rnas that target trac gene and methods of use |
| EP4637841A1 (en) * | 2022-12-22 | 2025-10-29 | Mammoth Biosciences, Inc. | Compositions and methods for modifying dux4 |
| EP4673550A2 (en) * | 2023-02-27 | 2026-01-07 | Mammoth Biosciences, Inc. | Compositions and methods for the modification and regulation of liver gene expression |
| AU2024236558A1 (en) | 2023-03-15 | 2025-10-09 | Renagade Therapeutics Management Inc. | Delivery of gene editing systems and methods of use thereof |
| WO2024238321A1 (en) * | 2023-05-12 | 2024-11-21 | Mammoth Biosciences, Inc. | Compositions and methods for targeted epigenetic modification |
| CN116844639B (zh) * | 2023-06-14 | 2025-09-12 | 上海诚明融鑫科技有限公司 | 一种具有自适应学习控制能力的人类mtDNA快速比对方法及装置 |
| AU2024335327A1 (en) | 2023-09-01 | 2026-03-26 | Renagade Therapeutics Management Inc. | Gene editing systems, compositions, and methods for treatment of vexas syndrome |
| WO2025050015A1 (en) * | 2023-09-01 | 2025-03-06 | Script Biosciences, Inc. | Compositions and methods for targeted modification of msh3 |
| WO2025174765A1 (en) | 2024-02-12 | 2025-08-21 | Renagade Therapeutics Management Inc. | Lipid nanoparticles comprising coding rna molecules for use in gene editing and as vaccines and therapeutic agents |
| CN119351374B (zh) * | 2024-12-23 | 2025-03-25 | 内蒙古大学 | 工程化改造超紧凑型CRISPR/Cas12j-8及其应用 |
| CN120330238B (zh) * | 2025-04-10 | 2025-12-23 | 北京林业大学 | 一种ect2基因在调控杨树次生木质部发育中的应用 |
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| US20050108791A1 (en) * | 2001-12-04 | 2005-05-19 | Edgerton Michael D. | Transgenic plants with improved phenotypes |
| US20110275135A1 (en) * | 2010-05-05 | 2011-11-10 | Battelle Energy Alliance, Llc | Genetic elements, proteins, and associated methods including application of additional genetic information to gram (+) thermoacidophiles |
| WO2012164565A1 (en) * | 2011-06-01 | 2012-12-06 | Yeda Research And Development Co. Ltd. | Compositions and methods for downregulating prokaryotic genes |
| WO2015161276A2 (en) * | 2014-04-18 | 2015-10-22 | Editas Medicine, Inc. | Crispr-cas-related methods, compositions and components for cancer immunotherapy |
| US9790490B2 (en) * | 2015-06-18 | 2017-10-17 | The Broad Institute Inc. | CRISPR enzymes and systems |
| AU2016380351B2 (en) * | 2015-12-29 | 2023-04-06 | Monsanto Technology Llc | Novel CRISPR-associated transposases and uses thereof |
| EP3445853A1 (en) * | 2016-04-19 | 2019-02-27 | The Broad Institute, Inc. | Cpf1 complexes with reduced indel activity |
| EP3830301B1 (en) * | 2018-08-01 | 2024-05-22 | Mammoth Biosciences, Inc. | Programmable nuclease compositions and methods of use thereof |
| MX2021010559A (es) * | 2019-03-07 | 2021-12-15 | Univ California | Polipéptidos efectores de crispr-cas y métodos de uso de estos. |
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| US20230357735A1 (en) | 2023-11-09 |
| JP2023529151A (ja) | 2023-07-07 |
| US20250066797A1 (en) | 2025-02-27 |
| CA3178670A1 (en) | 2021-12-09 |
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