CN116203258A - Sample analyzer and control method thereof - Google Patents

Sample analyzer and control method thereof Download PDF

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Publication number
CN116203258A
CN116203258A CN202111453536.5A CN202111453536A CN116203258A CN 116203258 A CN116203258 A CN 116203258A CN 202111453536 A CN202111453536 A CN 202111453536A CN 116203258 A CN116203258 A CN 116203258A
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China
Prior art keywords
water
level sensor
water level
float
water tank
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CN202111453536.5A
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Chinese (zh)
Inventor
韩维春
宋斌
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Shenzhen Mindray Bio Medical Electronics Co Ltd
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Shenzhen Mindray Bio Medical Electronics Co Ltd
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Priority to CN202111453536.5A priority Critical patent/CN116203258A/en
Publication of CN116203258A publication Critical patent/CN116203258A/en
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/00584—Control arrangements for automatic analysers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B08—CLEANING
    • B08B—CLEANING IN GENERAL; PREVENTION OF FOULING IN GENERAL
    • B08B13/00—Accessories or details of general applicability for machines or apparatus for cleaning
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B08—CLEANING
    • B08B—CLEANING IN GENERAL; PREVENTION OF FOULING IN GENERAL
    • B08B3/00—Cleaning by methods involving the use or presence of liquid or steam
    • B08B3/04—Cleaning involving contact with liquid
    • B08B3/10—Cleaning involving contact with liquid with additional treatment of the liquid or of the object being cleaned, e.g. by heat, by electricity or by vibration
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01F—MEASURING VOLUME, VOLUME FLOW, MASS FLOW OR LIQUID LEVEL; METERING BY VOLUME
    • G01F23/00—Indicating or measuring liquid level or level of fluent solid material, e.g. indicating in terms of volume or indicating by means of an alarm
    • G01F23/30—Indicating or measuring liquid level or level of fluent solid material, e.g. indicating in terms of volume or indicating by means of an alarm by floats
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
    • G01N35/025—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations having a carousel or turntable for reaction cells or cuvettes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
    • G01N35/1004—Cleaning sample transfer devices
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
    • G01N35/04—Details of the conveyor system
    • G01N2035/0401—Sample carriers, cuvettes or reaction vessels
    • G01N2035/0437—Cleaning cuvettes or reaction vessels
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Chemical & Material Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Fluid Mechanics (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)

Abstract

The invention discloses a sample analysis device and a control method thereof, wherein the water temperature of a liquid inlet is compared with a preset temperature value, when the water temperature of the liquid inlet is smaller than the preset temperature value, preset operation is carried out, and the water inflow amount of unit time from the liquid inlet to a water tank is reduced, so that the impact of external water inflow on the temperature of cleaning water in the water tank can be reduced, the stability of the temperature of the cleaning water in the water tank in the water inflow process can be improved, and the influence on the cleaning effect is reduced.

Description

Sample analyzer and control method thereof
Technical Field
The present invention relates to a sample analyzer and a control method thereof.
Background
A sample analyzer, such as a biochemical analyzer, is a medical device for detecting various analysis indexes of blood, urine, or other body fluids, and when the sample analyzer is used to detect various analysis indexes, it is necessary to process a sample and a reagent using a sample needle, a reagent needle, a stirring rod, and a reaction cup. In the working process of the sample analysis device, the sample needle, the reagent needle, the stirring rod and the reaction cup can be contacted with different liquid media, so that in order to eliminate carrying pollution among different media, a water tank arranged in the sample analysis device is required to be used for providing cleaning water to clean and maintain the devices, cross pollution among different media is eliminated, and the accuracy of a test result is ensured.
When the cleaning water in the water tank is insufficient, the sample analysis device can supplement the cleaning water in an external water inlet mode, and in general, the higher the temperature of the cleaning water provided by the water tank, the more beneficial to cleaning devices, but because the external water inlet is not subjected to heating treatment, the lower the water inlet temperature, the larger the temperature change of the cleaning water in the water tank in the water inlet process can be caused, so that the subsequent cleaning effect is influenced.
Disclosure of Invention
The following is a summary of the subject matter described in detail herein. This summary is not intended to limit the scope of the claims.
The embodiment of the invention provides a sample analysis device and a control method thereof, which can improve the stability of the temperature of cleaning water in a water tank in the water inlet process and reduce the influence on the cleaning effect.
In one aspect, an embodiment of the present invention provides a sample analysis device, including:
a dispensing mechanism comprising a movement assembly and a pipetting needle connected to the movement assembly, the movement assembly for driving the pipetting needle to move between different operating positions to aspirate or discharge a target liquid comprising at least one of a sample or a reagent;
the cleaning mechanism comprises a first liquid outlet and is used for discharging cleaning liquid through the first liquid outlet so as to clean the pipetting needle;
The liquid path supporting mechanism comprises a water tank, a water pump and a liquid supply pipeline, wherein the water tank comprises a liquid inlet and a second liquid outlet, and the second liquid outlet is sequentially communicated with the water pump and the first liquid outlet through the liquid supply pipeline;
the temperature sensor is positioned at the liquid inlet and used for acquiring the water temperature of the liquid inlet;
the heating device is used for heating the cleaning water in the water tank;
and the controller is used for executing preset operation when the water temperature of the liquid inlet is smaller than a preset temperature value so as to reduce the water inflow amount in unit time entering the water tank from the liquid inlet.
Optionally, the liquid inlet is connected with a water inlet pipe, the water inlet pipe is provided with a water inlet valve, and the water inlet valve is electrically connected with the controller; the preset operation includes adjusting an opening of the water inlet valve.
Optionally, the water tank is provided with a trigger float, a first water level sensor and a second water level sensor, and the position of the first water level sensor in the water tank is lower than the position of the second water level sensor in the water tank; the controller is also used for adjusting the opening of the water inlet valve when the water temperature of the liquid inlet is smaller than a preset temperature value and the triggering floater triggers the first water level sensor, and reducing the water inflow in unit time entering the water tank from the liquid inlet until the triggering floater triggers the second water level sensor.
Optionally, when the liquid level in the water tank is at the position of the first water level sensor, the water tank has a first volume of washing water; when the liquid level in the water tank is at the position of the second water level sensor, the water tank has a second volume of washing water; the difference between the second volume and the first volume is less than or equal to the product of the second volume and a volume coefficient, wherein the volume coefficient is a positive number less than or equal to one sixth.
Optionally, the preset operation includes at least one of:
controlling the intermittent opening of the water inlet valve;
and reducing the opening degree of the water inlet valve.
Optionally, the controller controls the intermittent opening of the water inlet valve to execute:
and controlling the water inlet valve to be intermittently opened according to a preset opening time and a preset closing time, wherein the water inflow of the water tank corresponding to the preset opening time is larger than the water consumption of the water tank corresponding to the preset closing time.
Optionally, the preset opening time is calculated according to an intermittent switching period, current water consumption per unit time, water inflow per unit time and preset increment; the preset closing time length is the difference value between the intermittent switch period and the preset opening time length.
Optionally, the water tank is further provided with a third water level sensor, and the position of the third water level sensor in the water tank is lower than the position of the first water level sensor in the water tank; when the triggering floater triggers the third water level sensor, the controller controls the water inlet valve to be opened and sends out an alarm signal.
Optionally, the water tank is further provided with a fourth water level sensor, and the position of the fourth water level sensor in the water tank is higher than the position of the second water level sensor in the water tank; when the trigger floater triggers the fourth water level sensor, the controller controls the water inlet valve to be closed and sends out an alarm signal.
Optionally, the triggering float includes first float, second float and third float, first float the second float and the third float sets gradually from the top down through the connecting rod, wherein:
the first floater is used for triggering the fourth water level sensor, the second floater is used for triggering the first water level sensor or the second water level sensor, and the third floater is used for triggering the third water level sensor;
or alternatively, the process may be performed,
the first floater is used for triggering the fourth water level sensor or the second water level sensor, the second floater is used for triggering the first water level sensor, and the third floater is used for triggering the third water level sensor;
Or alternatively, the process may be performed,
the first floater is used for triggering the fourth water level sensor, the second floater is used for triggering the second water level sensor, and the third floater is used for triggering the first water level sensor or the third water level sensor.
Optionally, the triggering floater comprises a fourth floater, a fifth floater, a sixth floater and a seventh floater, and the fourth floater, the fifth floater, the sixth floater and the seventh floater are sequentially arranged from top to bottom through a connecting rod; the fourth floater is used for triggering the fourth water level sensor, the fifth floater is used for triggering the second water level sensor, the sixth floater is used for triggering the first water level sensor, and the seventh floater is used for triggering the third water level sensor.
Optionally, the triggering floater comprises an eighth floater and a ninth floater, and the eighth floater and the ninth floater are sequentially arranged from top to bottom through a connecting rod; the eighth float is used for triggering the fourth water level sensor or the second water level sensor, and the ninth float is used for triggering the first water level sensor or the third water level sensor.
On the other hand, the embodiment of the invention also provides a control method of the sample analysis device, which comprises the following steps:
Acquiring the water inlet temperature detected by a temperature sensor of a liquid inlet of a water tank of the sample analysis device;
when the water inlet temperature is smaller than a preset temperature value, preset operation is executed to reduce the water inlet amount of unit time entering the water tank from the liquid inlet.
Optionally, the liquid inlet is connected with a water inlet pipe, the water inlet pipe is provided with a water inlet valve, and the water inlet valve is connected to the water inlet pipe of the liquid inlet; the preset operation includes at least one of:
controlling the intermittent opening of the water inlet valve;
and reducing the opening degree of the water inlet valve.
In another aspect, an embodiment of the present invention further provides a sample analysis apparatus, including: a memory, a processor and a computer program stored on the memory and executable on the processor, which processor implements the control method as described above when executing the computer program.
In another aspect, embodiments of the present invention also provide a computer-readable storage medium storing computer-executable instructions for performing a control method as described above.
In another aspect, embodiments of the present invention further provide a computer program product, including a computer program or computer instructions stored in a computer-readable storage medium, from which a processor of a computer device reads the computer program or the computer instructions, the processor executing the computer program or the computer instructions, causing the computer device to execute the control method as described above.
According to the sample analysis device, the control method of the sample analysis device, the computer readable storage medium and the computer program product of the above embodiments, by comparing the water temperature of the liquid inlet with the preset temperature value, when the water temperature of the liquid inlet is smaller than the preset temperature value, the preset operation is performed, and the water inflow amount per unit time from the liquid inlet to the water tank is reduced, so that the impact of external water inflow on the temperature of the cleaning water in the water tank can be reduced, the stability of the temperature of the cleaning water in the water tank in the water inflow process can be improved, and the influence on the cleaning effect can be reduced.
Additional features and advantages of the invention will be set forth in the description which follows, and in part will be obvious from the description, or may be learned by practice of the invention. The objectives and other advantages of the invention will be realized and attained by the structure particularly pointed out in the written description and claims hereof as well as the appended drawings.
Drawings
The accompanying drawings are included to provide a further understanding of the invention and are incorporated in and constitute a part of this specification, illustrate and do not limit the invention.
FIG. 1 is a schematic diagram of a sample analysis device in accordance with one embodiment of the present invention;
FIG. 2 is a schematic view of a sample analysis device according to another embodiment of the present invention;
FIG. 3 is a schematic illustration of a water tank of a sample analysis device in accordance with one embodiment of the present invention;
FIG. 4 is a schematic view showing an internal structure of a water tank of a sample analysis device according to an embodiment of the present invention;
FIG. 5 is a schematic view showing an internal structure of a water tank of a sample analyzing apparatus according to another embodiment of the present invention;
FIG. 6 is a schematic view showing an internal structure of a water tank of a sample analyzing apparatus according to another embodiment of the present invention;
FIG. 7 is a schematic view showing an internal structure of a water tank of a sample analyzing apparatus according to another embodiment of the present invention;
FIG. 8 is a schematic view showing an internal structure of a water tank of a sample analyzing apparatus according to another embodiment of the present invention;
FIG. 9 is a schematic view showing an internal structure of a water tank of a sample analyzing apparatus according to another embodiment of the present invention;
FIG. 10 is a schematic view showing an internal structure of a water tank of a sample analyzing apparatus according to another embodiment of the present invention;
FIG. 11 is a flow chart of a method of controlling a sample analysis device in one embodiment of the invention.
Detailed Description
The present invention will be described in further detail with reference to the drawings and examples, in order to make the objects, technical solutions and advantages of the present invention more apparent. It should be understood that the specific embodiments described herein are for purposes of illustration only and are not intended to limit the scope of the invention.
It should be noted that although a logical order is illustrated in the flowchart, in some cases, the steps illustrated or described may be performed in an order different from that in the flowchart. The terms first, second and the like in the description and in the claims and in the above-described figures, are used for distinguishing between similar elements and not necessarily for describing a particular sequential or chronological order.
A sample analyzer, such as a biochemical analyzer, is a medical device for detecting various analysis indexes of blood, urine, or other body fluids, and when the sample analyzer is used to detect various analysis indexes, it is necessary to process a sample and a reagent using a sample needle, a reagent needle, a stirring rod, and a reaction cup. The general process of detecting a sample by using a sample analysis device mainly comprises the following steps: the sample needle absorbs the sample and discharges the sample into the reaction cup, the reagent needle absorbs the reagent and discharges the reagent into the reaction cup, the stirring rod is used for uniformly mixing reaction liquid prepared by at least the sample and the reagent in the reaction cup, after the reaction liquid is fully and uniformly mixed, the mixed reaction liquid is incubated, and then the incubated reaction liquid is measured.
According to the general process of detecting the sample by the sample analysis device, in the working process of the sample analysis device, the sample needle, the reagent needle, the stirring rod and the reaction cup can be contacted with different liquid media, so that in order to eliminate the carrying pollution among different media, a water tank arranged in the sample analysis device is required to be used for providing cleaning water for cleaning and maintaining the devices, the cross pollution among different media is eliminated, and the accuracy of the test result is ensured.
When the cleaning water in the water tank is insufficient, the sample analysis device can supplement the cleaning water in an external water inlet mode, and in general, the higher the temperature of the cleaning water provided by the water tank, the more beneficial to cleaning devices, but because the external water inlet is not subjected to heating treatment, the lower the water inlet temperature, the larger the temperature change of the cleaning water in the water tank in the water inlet process can be caused, so that the subsequent cleaning effect is influenced.
In order to solve the problem that the subsequent cleaning effect is affected due to the fact that the temperature of the cleaning water in the water tank is greatly changed in the water inlet process, the invention provides a sample analysis device, a control method of the sample analysis device, a computer readable storage medium and a computer program product.
Embodiments of the present invention will be further described below with reference to the accompanying drawings.
Referring to fig. 1, fig. 1 is a schematic diagram of a sample analysis device according to an embodiment of the present invention. In the example of fig. 1, the sample analysis device may include a dispensing mechanism 10, a washing mechanism 20, a liquid path support mechanism, a temperature sensor 40, a heating device 50, and a controller 60.
The dispensing mechanism 10 is used to achieve dispensing of a sample and dispensing of a reagent. In some examples, the dispensing mechanism 10 may include a movement assembly (not shown) for driving the pipetting needle between different operating positions to aspirate or discharge a target fluid, including at least one of a sample or a reagent, and a pipetting needle (not shown) coupled to the movement assembly. In some examples, the dispensing mechanism 10 may include a sample dispensing mechanism and a reagent dispensing mechanism, wherein the sample dispensing mechanism includes a sample needle drive mechanism and a sample needle, the reagent dispensing mechanism includes a reagent needle drive mechanism and a reagent needle, that is, the movement assembly includes a sample needle drive mechanism and a reagent needle drive mechanism, and the pipetting needle includes a sample needle and a reagent needle. The sample needle driving mechanism can drive the sample needle to move so as to suck the sample and discharge the sample into the reaction cup at the sample adding position. The sample needle driving mechanism may be a two-dimensional or three-dimensional driving mechanism capable of driving the sample needle to perform a two-dimensional or three-dimensional motion in space so that the sample needle can be moved to suck up the sample and to move to the cuvette to be loaded with the sample and discharge the sample to the cuvette. The reagent needle driving mechanism can drive the reagent needle to move so as to suck the reagent and discharge the reagent into the reaction cup at the reagent adding position. The reagent needle driving mechanism may be a two-dimensional or three-dimensional driving mechanism capable of driving the reagent needle to perform a two-dimensional or three-dimensional motion in space, so that the reagent needle can move to suck the reagent and move to the reaction cup to be filled with the reagent and discharge the reagent to the reaction cup.
The cleaning mechanism 20 is used to discharge a cleaning liquid to clean the pipetting needle. In some examples, the cleaning mechanism 20 may include a first fluid outlet 21, and the cleaning mechanism 20 may be capable of discharging cleaning fluid through the first fluid outlet 21 to clean the pipette needle.
The liquid path support mechanism is used to supply washing water so that the washing mechanism 20 can use the washing water to wash the pipetting needle. In some examples, the liquid path supporting mechanism includes a water tank 31, a water pump 32, and a liquid supply pipe 33, the water tank 31 includes a liquid inlet 311 and a second liquid outlet 312, and the second liquid outlet 312 is sequentially communicated with the water pump 32 and the first liquid outlet 21 through the liquid supply pipe 33.
The temperature sensor 40 detects the water temperature of the liquid inlet 311 and transmits the detected water temperature to the controller 60. In some examples, the temperature sensor 40 is disposed at the inlet 311, and obtains the water temperature of the inlet 311 in real time.
The heating device 50 is used for heating the washing water in the water tank 31. In some examples, the water tank 31 further includes a return port 313, the heating device 50 is connected between the water pump 32 and the first liquid outlet 21, and a water separator 70 is further connected between the heating device 50 and the first liquid outlet 21, the water separator 70 includes a water supply port 71, a return port 72, and a bypass port 73, wherein the water supply port 71 is connected to the heating device 50, the return port 72 is connected to the return port 313, and the bypass port 73 is connected to the first liquid outlet 21. The cleaning water in the water tank 31 is input into the heating device 50 through the water pump 32 for heating, the heated cleaning water enters the water separator 70 through the water supply port 71 and flows back into the water tank 31 from the water return port 72 of the water separator 70 through the liquid return port 313, so that the water tank 31 can store the heated cleaning water, and the pipette needle can be cleaned by using the heated cleaning water. When the pipetting needle needs to be cleaned, the heated cleaning water is discharged from the branch port 73 of the water separator 70 through the first liquid outlet 21, so that the pipetting needle can be cleaned.
The controller 60 is used for controlling the dispensing mechanism 10, the cleaning mechanism 20, the liquid path support mechanism, the temperature sensor 40 and the heating device 50 to operate, for example, the controller 60 controls the temperature sensor 40 to obtain the water temperature of the liquid inlet 311, and when the water temperature of the liquid inlet 311 is smaller than a preset temperature value, the controller 60 performs a preset operation to reduce the water inflow amount per unit time from the liquid inlet 311 to the water tank 31. In addition, in some examples, the controller 60 also controls the moving assembly in the dispensing mechanism 10 to drive the pipetting needle to move between different operation positions to suck or discharge the target liquid, controls the washing mechanism 20 to discharge the washing liquid to wash the pipetting needle, controls the water pump 32 in the liquid path support mechanism to pump the washing water in the water tank 31 to wash the pipetting needle, controls the temperature sensor 40 to detect the water temperature of the liquid inlet 311 of the water tank 31, and controls the heating device 50 to heat the washing water.
Furthermore, in some embodiments, referring to fig. 2, the sample analysis device further includes a sample unit 120, a reagent unit 80, a reaction unit 90, a mixing mechanism 100, and an assay unit 110.
The sample unit 120 is used for carrying a sample to be sampled. In some examples, the sample unit 120 may include a sample distribution module (SDM, sample Delivery Module) and a front-end track; in other examples, the sample cell 120 may also be a sample tray that includes a plurality of sample locations where sample tubes, for example, may be placed, and the sample tray may be maneuvered to a corresponding location, for example, to a location where a sample dispensing mechanism draws sample, by rotating its tray structure.
The reagent unit 80 is used for carrying a reagent. In some examples, the reagent unit 80 may be a reagent disk, where the reagent disk is provided in a disk-shaped structure and has a plurality of positions for carrying reagent containers, and the reagent unit 80 can rotate and drive the reagent containers carried by the reagent unit to rotate to a specific position, for example, a position where the reagent is sucked by the reagent dispensing mechanism. The number of reagent units 80 may be one or more.
The reaction unit 90 has a plurality of placement sites for placing reaction cups, and the reaction unit 90 is used for incubating a reaction solution in the reaction cups on the placement sites, wherein the reaction solution is prepared from at least a sample and a reagent. In some examples, the reaction unit 90 may be a reaction disk, which is configured in a disk-shaped structure, and has one or more placement positions for placing reaction cups, and the reaction disk can rotate and drive the reaction cups in the placement positions to rotate, so as to schedule the reaction cups in the reaction disk and incubate the reaction liquid in the reaction cups. It should be noted that, in the sample addition position, the reagent addition position, the mixing position, the measuring position, etc., which are referred to in the different embodiments, may be the placement positions of some positions in the reaction unit 90, that is, the sample addition position, the reagent addition position, the mixing position, the measuring position, etc., may be disposed in the reaction unit 90.
The mixing mechanism 100 is used for mixing the reaction solution to be mixed in the reaction cup, wherein the mixing mechanism 100 comprises a stirring rod driving mechanism (not shown in the figure) and a stirring rod (not shown in the figure), and the stirring rod driving mechanism can drive the stirring rod to move and perform stirring action. The number of stirring rods may be one or more, and when the number of stirring rods is a plurality of stirring rods, other stirring rods can be cleaned by using the time when one stirring rod performs stirring action.
The measurement unit 110 is used for measuring the reaction solution. For example, the measurement unit 110 is configured to measure a reaction solution in a cuvette at a measurement site after incubation is completed, so as to obtain a measurement result. In some examples, the measurement unit 110 may be a photometric measurement unit, which may detect the luminescence intensity or absorbance of the reaction solution to be measured, and then calculate the concentration of the component to be measured in the sample, etc., through a calibration curve. In some examples, the measurement unit 110 may be separately provided outside the reaction unit 90.
In the case that the sample analysis apparatus further includes the reaction unit 90, the mixing mechanism 100, and the measurement unit 110, the controller 60 may control the reaction unit 90 to rotate and drive the reaction cup in the placement position to rotate so as to implement the dispatching process of the reaction cup, the incubation process of the reaction liquid in the reaction cup, control the mixing mechanism 100 to mix the reaction liquid in the reaction cup located in the mixing position, and control the measurement unit 110 to measure the reaction liquid.
Referring to fig. 3, in some embodiments, the liquid inlet 311 is connected with a water inlet pipe 314, the water inlet pipe 314 is provided with a water inlet valve 315, and the water inlet valve 315 is electrically connected with the controller 60, in which case, the preset operation performed by the controller 60 may include adjusting the opening degree of the water inlet valve 315, reducing the inflow amount per unit time from the liquid inlet 311 to the water tank 31, so that the impact of external inflow on the temperature of the cleaning water in the water tank 31 may be reduced, and further the stability of the temperature of the cleaning water in the water tank 31 during the inflow process may be improved, and the impact on the cleaning effect may be reduced.
In some embodiments, the preset operation performed by the controller 60 may specifically include at least one of controlling the fill valve 315 to intermittently open or decreasing the opening of the fill valve 315.
Intermittent opening of the water inlet valve 315 is controlled by the controller 60, which means that after the controller 60 controls the water inlet valve 315 to open for a period of time, controls the water inlet valve 315 to close for a period of time, controls the water inlet valve 315 to open for a period of time, and then controls the water inlet valve 315 to close for a period of time, so that the cycle is performed until the level of the washing water in the water tank 31 reaches a preset position (for example, until the level reaches a full water position).
Decreasing the opening of the water inlet valve 315 means that the controller 60 controls the opening of the water inlet valve 315 to decrease during the water inlet of the water tank 31, and decreases the inflow amount per unit time into the water tank 31 until the level of the washing water in the water tank 31 reaches a preset position (for example, until the level reaches a full water position).
In some embodiments, when the controller 60 controls the water inlet valve 315 to be intermittently opened, the controller 60 controls the water inlet valve 315 to be intermittently opened according to a preset opening duration and a preset closing duration, wherein the water inlet amount of the water tank corresponding to the preset opening duration is greater than the water consumption amount of the water tank corresponding to the preset closing duration, that is, the water tank 31 can be ensured to store cleaning water at any time, so that the influence on the cleaning of the pipetting needle due to the water shortage of the water tank 31 can be avoided.
In some embodiments, the preset opening time period may be calculated according to the intermittent switching period, the current water consumption per unit time, the water inflow per unit time, and the preset increment, and the preset closing time period may be a difference between the intermittent switching period and the preset opening time period. In some examples, the preset open time period may be calculated by the following formula (1):
T O ＝T*((V O /3600)/(V I /T in )+a) (1)
in formula (1), T O Is a preset beatThe on-time length; t is an intermittent switching period; v (V) O Water consumption per hour O 3600) is the current water consumption per unit time (i.e., water consumption per second); v (V) I T is the volume between the position where the water inlet is triggered and the position where the water inlet is stopped is triggered by the rise of the liquid level of the cleaning water in the water tank 31 in For the time (in seconds) required for the liquid level of the washing water in the water tank 31 to rise from the position where water inflow is triggered to the position where water inflow is stopped under the normal water inflow condition (V) I /T in ) The water inflow is the unit time; a is a preset increment, for example, a positive number less than 1. It should be noted that, the specific value of the preset increment may be appropriately adjusted according to the actual application, and this embodiment is not particularly limited, for example, a may be 0.1.
After the preset opening time is calculated according to the above formula (1), the preset closing time can be calculated according to the following formula (2):
T C ＝T-T O (2)
in formula (2), T C The method comprises the steps of presetting an opening time length; t is the intermittent switching period in the formula (1); t (T) O The preset opening time period in the above formula (1).
The specific value of the intermittent switching period T may be appropriately selected according to the actual application, which is not particularly limited in this embodiment.
The above description is related to some parts and functions of the sample analysis device, and the operation of the sample analysis device will be described in detail below.
Generally, one item test of a sample analysis device requires the following procedure: the sample needle sucks a sample from the sample sucking position and discharges the sample into a reaction cup positioned at the sample adding position; the reagent needle sucks the reagent from the reagent sucking position and discharges the reagent into the reaction cup positioned at the reagent adding position; the stirring rod is used for uniformly mixing a reaction liquid prepared from at least a sample and a reagent in the reaction cup; incubating the reaction liquid in the reaction cup; the reaction solution after completion of incubation was measured. In this process, the sample needle generally needs to be cleaned after discharging one sample and before sucking the next sample to prevent cross contamination; similarly, reagent needles typically need to be cleaned after discharging a reagent and before aspirating the next reagent to prevent cross-contamination; similarly, after the stirring rod has stirred the reaction liquid in one reaction cup and before stirring the reaction liquid in the next reaction cup, it is generally necessary to perform cleaning to prevent cross contamination.
Thus, in one particular test procedure, the controller 60 controls the sample needle drive mechanism to drive the sample needle to move to the sample cell 120 to aspirate the sample to be sampled and to discharge to the cuvette at the sample site; the controller 60 controls the reagent needle driving mechanism to drive the reagent needle to move to the reagent unit 80 to aspirate the reagent and discharge to the cuvette at the reagent site. It will be appreciated that the sample and reagent addition may be performed simultaneously or sequentially and may be performed by first adding the sample and then the reagent or may be performed by first adding the reagent and then the sample. Next, the controller 60 controls the mixing mechanism 100 to mix the reaction solution, the controller 60 controls the reaction unit 90 to incubate the reaction solution, and when incubation is completed, the controller 60 controls the measurement unit 110 to measure the incubated reaction solution.
In the above-described process, it is known that the sample needle, the reagent needle, the stirring rod, and the like need to be cleaned in the test flow in order to prevent cross contamination. In the process of cleaning the sample needle, the reagent needle, the stirring rod and the like, cleaning water in the water tank 31 is consumed, when the water tank 31 is deficient and the cleaning water needs to be replenished in an external water inlet mode, the controller 60 controls the temperature sensor 40 to acquire the water temperature of the liquid inlet 311 and judge whether the water temperature of the liquid inlet 311 is smaller than a preset temperature value, when the controller 60 determines that the water temperature of the liquid inlet 311 is smaller than the preset temperature value, the controller 60 controls the water inlet valve 315 to intermittently open, controls the water inlet valve 315 to reduce the opening, or controls the water inlet valve 315 to reduce the opening while controlling the water inlet valve 315 to intermittently open, thereby reducing the impact of external water inlet on the temperature of the cleaning water in the water tank 31, further improving the stability of the temperature of the cleaning water in the water tank 31 in the water inlet process and reducing the influence on the cleaning effect.
It should be noted that the preset temperature value may be appropriately selected according to the actual application, which is not particularly limited in this embodiment. For example, the preset temperature value may be set to any value between 20 ℃ and 30 ℃.
The above description is a description of the operation of the sample analyzer, and the structure of the water tank 31 will be specifically described below.
Referring to fig. 4, in some embodiments, the water tank 31 is provided with a trigger float 316, a first water level sensor 317, and a second water level sensor 318, wherein the first water level sensor 317 is located lower in the water tank 31 than the second water level sensor 318 is located in the water tank 31. When the water temperature of the inlet 311 is less than the preset temperature value and the trigger float 316 triggers the first water level sensor 317, the controller 60 adjusts the opening degree of the water inlet valve 315 to reduce the amount of water inlet per unit time from the inlet 311 into the water tank 31 until the trigger float 316 triggers the second water level sensor 318. Through setting up trigger float 316, first water level sensor 317 and second water level sensor 318 in water tank 31 to through the cooperation between trigger float 316, first water level sensor 317 and the second water level sensor 318 realization to the intaking of water tank 31 and stop intaking, can guarantee that the liquid level is in reasonable within range in the water tank 31, thereby can guarantee reliable water, avoid influencing the washing to the pipetting needle because water tank 31 lacks water.
It should be noted that, when the water temperature of the liquid inlet 311 is greater than or equal to the preset temperature value and the trigger float 316 triggers the first water level sensor 317, the controller 60 will not reduce the water inflow amount per unit time into the water tank 31 by adjusting the opening of the water inlet valve 315, but will open or close the water inlet valve 315 in a conventional manner, that is, when the first water level sensor 317 is triggered by the trigger float 316 (i.e. when the liquid level is at a low level), the controller 60 opens the water inlet valve 315, timely supplements the water tank 31 with cleaning water, so as to ensure reliable water and avoid influencing the cleaning of the pipetting needle due to the water shortage of the water tank 31; when the second water level sensor 318 is triggered by the trigger float 316 (i.e. the liquid level is at a high water level), the controller 60 closes the water inlet valve 315, avoiding the overflow of the water tank 31 and resulting in a safety risk.
In some embodiments, the water tank 31 has a first volume of wash water when the liquid level in the water tank 31 is at the position of the first water level sensor 317; when the liquid level in the water tank 31 is at the position of the second water level sensor 318, the water tank 31 has a second volume of washing water. Wherein the first volume and the second volume satisfy the following formula (3):
V 2 -V 1 ≤b*V 2 (3)
In the formula (3), V 1 For a first volume, V 2 And b is a volume coefficient, that is, the difference between the second volume and the first volume is less than or equal to the product of the second volume and the volume coefficient. The positive-displacement coefficient is a positive number of one sixth or less. When the first volume and the second volume satisfy the above formula (3), the influence of the external inflow water on the temperature of the washing water in the water tank 31 can be effectively reduced, so that the stability of the temperature of the washing water in the water tank 31 in the inflow process can be improved, and the influence on the washing effect can be reduced.
It should be noted that, by providing the trigger float 316, the first water level sensor 317 and the second water level sensor 318 in the water tank 31, a control manner of opening water inflow when the liquid level in the water tank 31 is at a low water level and stopping water inflow when the liquid level in the water tank 31 is at a high water level can be realized, however, if the first water level sensor 317 fails, continuous water consumption occurs until the empty condition of the water tank 31 does not trigger the water inflow opening, thereby causing the water pump 32 to idle, and possibly causing damage to the water pump 32; if the second water level sensor 318 fails, continuous water inflow is caused until the water tank 31 overflows, and water inflow is not triggered to stop, so that cleaning water in the water tank 31 overflows to the inside of the sample analysis device, and risks such as electric shock or burning of the sample analysis device may occur. To avoid these problems, in some embodiments, referring to fig. 5, on the basis that the trigger float 316, the first water level sensor 317, and the second water level sensor 318 are provided in the water tank 31, a third water level sensor 319 and a fourth water level sensor 320 are further provided in the water tank 31, wherein the position of the third water level sensor 319 in the water tank 31 is lower than the position of the first water level sensor 317 in the water tank 31, and the position of the fourth water level sensor 320 in the water tank 31 is higher than the position of the second water level sensor 318 in the water tank 31. When the trigger float 316 triggers the third water level sensor 319, the controller 60 controls the water inlet valve 315 to open and issue an alarm signal; when the trigger float 316 triggers the fourth water level sensor 320, the controller 60 controls the water inlet valve 315 to close and issues an alarm signal. Through setting up the third water level sensor 319 that can play the guard action for under the condition that first water level sensor 317 breaks down, when last water consumption, trigger float 316 can descend along with the liquid level in water tank 31, when trigger float 316 triggers third water level sensor 319, controller 60 can control water intaking valve 315 and open and send alarm signal, can not only avoid the water tank 31 that causes because last water consumption appears empty case situation and water pump 32 appear idle running scheduling problem, can also inform the user through alarm signal, make the user in time maintain, thereby play the effect of protecting sample analytical equipment and guaranteeing the safe use of user to sample analytical equipment. Through setting up the fourth water level sensor 320 that can play the guard action for under the condition that second water level sensor 318 breaks down, when continuously intaking, trigger float 316 can rise along with the liquid level in the water tank 31, trigger float 316 and trigger fourth water level sensor 320, controller 60 can control water intaking valve 315 and close and send alarm signal, not only can avoid the water tank 31 that causes because continuously intaking to appear overflow situation and a series of problems that the follow-up probably appears, can also inform the user through alarm signal, make the user in time maintain, thereby play the effect of protecting sample analytical equipment and guaranteeing the safe handling of user to sample analytical equipment.
It should be noted that, in the water tank 31, the trigger float 316 may have a plurality of different arrangements, and the arrangement and the operation of the trigger float 316 will be specifically described below.
Referring to fig. 6, in some embodiments, the triggering float 316 may include a first float 3161, a second float 3162, and a third float 3163, the first float 3161, the second float 3162, and the third float 3163 being sequentially disposed from top to bottom by the connection rod 400, the connection rod 400 being provided with a first limit position 410 and a second limit position 420, the first limit position 410 being disposed between the fourth water level sensor 320 and the second water level sensor 318, the second limit position 420 being disposed between the first water level sensor 317 and the third water level sensor 319, the first float 3161, the first limit position 410, the second float 3162, the second limit position 420, and the third float 3163 being sequentially disposed, the first limit position 410 being for limiting the elevation of the first float 3161 or the second float 3162, and the second limit position 420 being for limiting the elevation of the second float 3162 or the third float 3163. The first float 3161 is used to trigger the fourth water level sensor 320, the second float 3162 is used to trigger the first water level sensor 317 or the second water level sensor 318, and the third float 3163 is used to trigger the third water level sensor 319. When the liquid level in the water tank 31 drops due to water consumption, when the second float 3162 triggers the first water level sensor 317 to indicate that the washing water in the water tank 31 is at a low water level, at this time, the controller 60 controls the water inlet valve 315 to be opened to replenish the water tank 31, so that the problem of water shortage of the water tank 31 is avoided; when the second float 3162 triggers the second water level sensor 318 to indicate that the washing water in the water tank 31 is at a high water level, at this time, the controller 60 controls the water inlet valve 315 to be closed to stop the water replenishment of the water tank 31, so that the overflow problem of the water tank 31 is avoided; when the third float 3163 triggers the third water level sensor 319, which indicates that the first water level sensor 317 is out of order and water in the water tank 31 is seriously lost, at this time, the controller 60 controls the water inlet valve 315 to be opened to replenish water in the water tank 31, so as to avoid the empty condition of the water tank 31 and the idle running of the water pump 32, and in addition, the controller 60 also sends an alarm signal to inform the user of timely maintenance; when the first float 3161 triggers the fourth water level sensor 320, indicating that the second water level sensor 318 is malfunctioning and the washing water in the water tank 31 has reached a limit, at this time, the controller 60 controls the water inlet valve 315 to be closed to stop the water supply to the water tank 31, avoiding the overflow problem of the water tank 31, and in addition, the controller 60 also sends an alarm signal to inform the user of timely maintenance.
Referring to fig. 7, in some embodiments, the triggering float 316 may include a first float 3161, a second float 3162, and a third float 3163, the first float 3161, the second float 3162, and the third float 3163 being sequentially disposed from top to bottom by the connection rod 400, the connection rod 400 being provided with a first limit position 410 and a second limit position 420, the first limit position 410 being disposed between the first water level sensor 317 and the second water level sensor 318, the second limit position 420 being disposed between the first water level sensor 317 and the third water level sensor 319, the first float 3161, the first limit position 410, the second float 3162, the second limit position 420, and the third float 3163 being sequentially disposed, the first limit position 410 being for limiting the elevation of the first float 3161 or the second float 3162, and the second limit position 420 being for limiting the elevation of the second float 3162 or the third float 3163. The first float 3161 is used to trigger the fourth water level sensor 320 or the second water level sensor 318, the second float 3162 is used to trigger the first water level sensor 317, and the third float 3163 is used to trigger the third water level sensor 319. When the liquid level in the water tank 31 drops due to water consumption, when the second float 3162 triggers the first water level sensor 317 to indicate that the washing water in the water tank 31 is at a low water level, at this time, the controller 60 controls the water inlet valve 315 to be opened to replenish the water tank 31, so that the problem of water shortage of the water tank 31 is avoided; when the first float 3161 triggers the second water level sensor 318 to indicate that the washing water in the water tank 31 is at a high water level, at this time, the controller 60 controls the water inlet valve 315 to be closed to stop the water replenishment of the water tank 31, so that the overflow problem of the water tank 31 is avoided; when the third float 3163 triggers the third water level sensor 319, which indicates that the first water level sensor 317 is out of order and water in the water tank 31 is seriously lost, at this time, the controller 60 controls the water inlet valve 315 to be opened to replenish water in the water tank 31, so as to avoid the empty condition of the water tank 31 and the idle running of the water pump 32, and in addition, the controller 60 also sends an alarm signal to inform the user of timely maintenance; when the first float 3161 triggers the fourth water level sensor 320, indicating that the second water level sensor 318 is malfunctioning and the washing water in the water tank 31 has reached a limit, at this time, the controller 60 controls the water inlet valve 315 to be closed to stop the water supply to the water tank 31, avoiding the overflow problem of the water tank 31, and in addition, the controller 60 also sends an alarm signal to inform the user of timely maintenance.
Referring to fig. 8, in some embodiments, the triggering float 316 may include a first float 3161, a second float 3162, and a third float 3163, the first float 3161, the second float 3162, and the third float 3163 being sequentially disposed from top to bottom by the connection rod 400, the connection rod 400 being provided with a first limit position 410 and a second limit position 420, the first limit position 410 being disposed between the fourth water level sensor 320 and the second water level sensor 318, the second limit position 420 being disposed between the first water level sensor 317 and the second water level sensor 318, the first float 3161, the first limit position 410, the second float 3162, the second limit position 420, and the third float 3163 being sequentially disposed, the first limit position 410 being for limiting the elevation of the first float 3161 or the second float 3162, and the second limit position 420 being for limiting the elevation of the second float 3162 or the third float 3163. The first float 3161 is used to trigger the fourth water level sensor 320, the second float 3162 is used to trigger the second water level sensor 318, and the third float 3163 is used to trigger the first water level sensor 317 or the third water level sensor 319. When the liquid level in the water tank 31 drops due to water consumption, when the third float 3163 triggers the first water level sensor 317 to indicate that the washing water in the water tank 31 is at a low water level, at this time, the controller 60 controls the water inlet valve 315 to be opened to replenish the water tank 31, thereby avoiding the water shortage problem of the water tank 31; when the second float 3162 triggers the second water level sensor 318 to indicate that the washing water in the water tank 31 is at a high water level, at this time, the controller 60 controls the water inlet valve 315 to be closed to stop the water replenishment of the water tank 31, so that the overflow problem of the water tank 31 is avoided; when the third float 3163 triggers the third water level sensor 319, which indicates that the first water level sensor 317 is out of order and water in the water tank 31 is seriously lost, at this time, the controller 60 controls the water inlet valve 315 to be opened to replenish water in the water tank 31, so as to avoid the empty condition of the water tank 31 and the idle running of the water pump 32, and in addition, the controller 60 also sends an alarm signal to inform the user of timely maintenance; when the first float 3161 triggers the fourth water level sensor 320, indicating that the second water level sensor 318 is malfunctioning and the washing water in the water tank 31 has reached a limit, at this time, the controller 60 controls the water inlet valve 315 to be closed to stop the water supply to the water tank 31, avoiding the overflow problem of the water tank 31, and in addition, the controller 60 also sends an alarm signal to inform the user of timely maintenance.
Referring to fig. 9, in some embodiments, the triggering floats 316 may include a fourth float 3164, a fifth float 3165, a sixth float 3166, and a seventh float 3167, the fourth float 3164, the fifth float 3165, the sixth float 3166, and the seventh float 3167 being sequentially disposed from top to bottom by the connecting rod 400, the connecting rod 400 being provided with a first limit position 410, a second limit position 420, and a third limit position 430, the first limit position 410 being disposed between the fourth water level sensor 320 and the second water level sensor 318, the second limit position 420 being disposed between the second water level sensor 318 and the first water level sensor 317, the third limit position 430 being disposed between the first water level sensor 317 and the third water level sensor 319, the fourth float 3164, the first limit position 410, the fifth float 3165, the second limit position 420, the sixth float 3166, the third limit position 430, and the seventh float 67 being sequentially disposed, the first limit position 410 for limiting the lifting of the fourth float 3164 or the fifth float 3165, the second limit position 420 being disposed for limiting the lifting of the sixth float 3165, or the sixth float 3165, the lifting of the sixth float 3165, or the limit position 3165 being disposed between the first limit position 3165. The fourth float 3164 is used to trigger the fourth water level sensor 320, the fifth float 3165 is used to trigger the second water level sensor 318, the sixth float 3166 is used to trigger the first water level sensor 317, and the seventh float 3167 is used to trigger the third water level sensor 319. When the liquid level in the water tank 31 drops due to water consumption, when the sixth float 3166 triggers the first water level sensor 317 to indicate that the washing water in the water tank 31 is at a low water level, at this time, the controller 60 controls the water inlet valve 315 to be opened to replenish the water tank 31, thereby avoiding the water shortage problem of the water tank 31; when the fifth float 3165 triggers the second water level sensor 318, indicating that the washing water in the water tank 31 is at a high water level, at this time, the controller 60 controls the water inlet valve 315 to be closed to stop the water replenishment of the water tank 31, thereby avoiding the overflow problem of the water tank 31; when the seventh float 3167 triggers the third water level sensor 319, indicating that the first water level sensor 317 is faulty and water in the water tank 31 is seriously deficient, at this time, the controller 60 controls the water inlet valve 315 to be opened to replenish water in the water tank 31, so as to avoid the empty condition of the water tank 31 and the idle running of the water pump 32, and in addition, the controller 60 also sends an alarm signal to inform the user of timely maintenance; when the fourth float 3164 triggers the fourth water level sensor 320, indicating that the second water level sensor 318 is malfunctioning and the washing water in the water tank 31 has reached a limit, at this time, the controller 60 controls the water inlet valve 315 to be closed to stop the water supply to the water tank 31, avoiding the overflow problem of the water tank 31, and in addition, the controller 60 also sends an alarm signal to inform the user of timely maintenance.
Referring to fig. 10, in some embodiments, the triggering floats 316 may include eighth and ninth floats 3168 and 3169, the eighth and ninth floats 3168 and 3169 being sequentially disposed from top to bottom by a connection rod 400, the connection rod 400 being provided with a first limit position 410, the first limit position 410 being disposed between the second and first water level sensors 318 and 317, the eighth, first and ninth floats 3168 and 3169 being sequentially disposed, the first limit position 410 being for limiting lifting of the eighth and ninth floats 3168 and 3169. The eighth float 3168 is used to trigger the fourth water level sensor 320 or the second water level sensor 318, and the ninth float 3169 is used to trigger the first water level sensor 317 or the third water level sensor 319. When the liquid level in the water tank 31 drops due to water consumption, when the ninth float 3169 triggers the first water level sensor 317 to indicate that the washing water in the water tank 31 is at a low water level, at this time, the controller 60 controls the water inlet valve 315 to be opened to replenish the water tank 31, thereby avoiding the water shortage problem of the water tank 31; when the eighth floater 3168 triggers the second water level sensor 318, which indicates that the washing water in the water tank 31 is at a high water level, the controller 60 controls the water inlet valve 315 to be closed to stop the water supply to the water tank 31, so that the overflow problem of the water tank 31 is avoided; when the ninth float 3169 triggers the third water level sensor 319, indicating that the first water level sensor 317 is faulty and water in the water tank 31 is seriously deficient, at this time, the controller 60 controls the water inlet valve 315 to be opened to replenish water in the water tank 31, so as to avoid the empty condition of the water tank 31 and the idle running of the water pump 32, and in addition, the controller 60 also sends an alarm signal to inform the user of timely maintenance; when the eighth float 3168 triggers the fourth water level sensor 320, indicating that the second water level sensor 318 is malfunctioning and the washing water in the water tank 31 has reached a limit, at this time, the controller 60 controls the water inlet valve 315 to be closed to stop the water supply to the water tank 31, avoiding the overflow problem of the water tank 31, and in addition, the controller 60 also sends an alarm signal to inform the user of timely maintenance.
The above are some of the descriptions for sample analysis devices. Next, referring to fig. 11, another embodiment of the present invention also discloses a control method of a sample analysis device, the control method comprising the steps of:
step S100: acquiring the water inlet temperature detected by a temperature sensor of a liquid inlet of a water tank of the sample analysis device;
step S200: when the water inlet temperature is smaller than a preset temperature value, a preset operation is performed to reduce the water inlet amount of the water tank in unit time from the liquid inlet.
The foregoing method steps involve performing a preset operation according to the water inlet temperature to reduce the water inlet amount per unit time from the water inlet to the water tank, which may be referred to in any of the foregoing embodiments for description of the sample analysis device, and in order to avoid redundancy of the content, a detailed description is omitted herein.
In some embodiments, when the inlet is connected with a water inlet pipe, the water inlet pipe is provided with a water inlet valve, and the water inlet valve is connected to the water inlet pipe of the inlet, the preset operation in step S200 includes at least one of:
controlling the intermittent opening of a water inlet valve;
and reducing the opening degree of the water inlet valve.
The intermittent opening of the water inlet valve is controlled, namely, after the water inlet valve is controlled to be opened for a period of time, the water inlet valve is controlled to be closed for a period of time, the water inlet valve is controlled to be opened for a period of time, and then the water inlet valve is controlled to be closed for a period of time, so that the circulation is performed until the liquid level of the cleaning water in the water tank reaches the full water position. Reducing the opening of the water inlet valve means that the opening of the water inlet valve is controlled to be reduced in the process of replenishing the water tank, and the water inflow amount of the water entering the water tank in unit time is reduced until the liquid level of the cleaning water in the water tank reaches a full water position.
In addition, an embodiment of the present invention also provides a sample analysis device including: memory, a processor, and a computer program stored on the memory and executable on the processor.
The processor and the memory may be connected by a bus or other means.
The memory, as a non-transitory computer readable storage medium, may be used to store non-transitory software programs as well as non-transitory computer executable programs. In addition, the memory may include high-speed random access memory, and may also include non-transitory memory, such as at least one magnetic disk storage device, flash memory device, or other non-transitory solid state storage device. In some embodiments, the memory optionally includes memory remotely located relative to the processor, the remote memory being connectable to the processor through a network. Examples of such networks include, but are not limited to, the internet, intranets, local area networks, mobile communication networks, and combinations thereof.
It should be noted that the sample analyzer in this embodiment may be applied to, for example, the sample analyzer in the embodiment shown in fig. 1, and these embodiments all belong to the same inventive concept, so these embodiments have the same implementation principle and technical effect, and will not be described in detail herein.
The non-transitory software programs and instructions required to implement the methods of operation of the above embodiments are stored in memory and when executed by a processor, perform the methods of control of the above embodiments.
The above described apparatus embodiments are merely illustrative, wherein the units illustrated as separate components may or may not be physically separate, i.e. may be located in one place, or may be distributed over a plurality of network elements. Some or all of the modules may be selected according to actual needs to achieve the purpose of the solution of this embodiment.
Furthermore, an embodiment of the present invention also provides a computer-readable storage medium storing computer-executable instructions for performing the control method as described above.
Furthermore, an embodiment of the present invention provides a computer program product including a computer program or computer instructions stored in a computer-readable storage medium, the computer program or computer instructions being read from the computer-readable storage medium by a processor of a computer device, the processor executing the computer program or computer instructions to cause the computer device to perform a control method as before.
Those of ordinary skill in the art will appreciate that all or some of the steps, systems, and methods disclosed above may be implemented as software, firmware, hardware, and suitable combinations thereof. Some or all of the physical components may be implemented as software executed by a processor, such as a central processing unit, digital signal processor, or microprocessor, or as hardware, or as an integrated circuit, such as an application specific integrated circuit. Such software may be distributed on computer readable media, which may include computer storage media (or non-transitory media) and communication media (or transitory media). The term computer storage media includes both volatile and nonvolatile, removable and non-removable media implemented in any method or technology for storage of information such as computer readable instructions, data structures, program modules or other data, as known to those skilled in the art. Computer storage media includes, but is not limited to, RAM, ROM, EEPROM, flash memory or other memory technology, CD-ROM, digital Versatile Disks (DVD) or other optical disk storage, magnetic cassettes, magnetic tape, magnetic disk storage or other magnetic storage devices, or any other medium which can be used to store the desired information and which can be accessed by a computer. Furthermore, as is well known to those of ordinary skill in the art, communication media typically embodies computer readable instructions, data structures, program modules or other data in a modulated data signal such as a carrier wave or other transport mechanism and includes any information delivery media.
While the preferred embodiment of the present invention has been described in detail, the present invention is not limited to the above embodiment, and various equivalent modifications and substitutions can be made by those skilled in the art without departing from the spirit of the present invention, and these equivalent modifications and substitutions are intended to be included in the scope of the present invention as defined in the appended claims.

Claims (14)

1. A sample analysis device, comprising:
a dispensing mechanism comprising a movement assembly and a pipetting needle connected to the movement assembly, the movement assembly for driving the pipetting needle to move between different operating positions to aspirate or discharge a target liquid comprising at least one of a sample or a reagent;
the cleaning mechanism comprises a first liquid outlet and is used for discharging cleaning liquid through the first liquid outlet so as to clean the pipetting needle;
the liquid path supporting mechanism comprises a water tank, a water pump and a liquid supply pipeline, wherein the water tank comprises a liquid inlet and a second liquid outlet, and the second liquid outlet is sequentially communicated with the water pump and the first liquid outlet through the liquid supply pipeline;
the temperature sensor is positioned at the liquid inlet and used for acquiring the water temperature of the liquid inlet;
The heating device is used for heating the cleaning water in the water tank;
and the controller is used for executing preset operation when the water temperature of the liquid inlet is smaller than a preset temperature value so as to reduce the water inflow amount in unit time entering the water tank from the liquid inlet.
2. The sample analysis device of claim 1, wherein the liquid inlet is connected to a water inlet pipe, the water inlet pipe is provided with a water inlet valve, and the water inlet valve is electrically connected with the controller; the preset operation includes adjusting an opening of the water inlet valve.
3. The sample analysis device according to claim 2, wherein the water tank is provided with a trigger float, a first water level sensor and a second water level sensor, the position of the first water level sensor in the water tank being lower than the position of the second water level sensor in the water tank; the controller is also used for adjusting the opening of the water inlet valve when the water temperature of the liquid inlet is smaller than a preset temperature value and the triggering floater triggers the first water level sensor, and reducing the water inflow in unit time entering the water tank from the liquid inlet until the triggering floater triggers the second water level sensor.
4. A sample analysis device according to claim 3, wherein the water tank has a first volume of wash water when the liquid level in the water tank is at the position of the first water level sensor; when the liquid level in the water tank is at the position of the second water level sensor, the water tank has a second volume of washing water; the difference between the second volume and the first volume is less than or equal to the product of the second volume and a volume coefficient, wherein the volume coefficient is a positive number less than or equal to one sixth.
5. The sample analysis device of claim 2, wherein the preset operation comprises at least one of:
controlling the intermittent opening of the water inlet valve;
and reducing the opening degree of the water inlet valve.
6. The sample analysis device of claim 5, wherein the controller performs when controlling the inlet valve to intermittently open:
and controlling the water inlet valve to be intermittently opened according to a preset opening time and a preset closing time, wherein the water inflow of the water tank corresponding to the preset opening time is larger than the water consumption of the water tank corresponding to the preset closing time.
7. The sample analysis device of claim 6, wherein the preset on-time is calculated from an intermittent switching period, a current water consumption per unit time, a water inflow per unit time, and a preset increment; the preset closing time length is the difference value between the intermittent switch period and the preset opening time length.
8. A sample analysis device according to claim 3, wherein the water tank is further provided with a third water level sensor, the position of the third water level sensor in the water tank being lower than the position of the first water level sensor in the water tank; when the triggering floater triggers the third water level sensor, the controller controls the water inlet valve to be opened and sends out an alarm signal.
9. The sample analysis device according to claim 8, wherein the water tank is further provided with a fourth water level sensor, the fourth water level sensor being located higher in the water tank than the second water level sensor; when the trigger floater triggers the fourth water level sensor, the controller controls the water inlet valve to be closed and sends out an alarm signal.
10. The sample analysis device of claim 9, wherein the trigger float comprises a first float, a second float, and a third float, the first float, the second float, and the third float being sequentially disposed from top to bottom by a connecting rod, wherein:
the first floater is used for triggering the fourth water level sensor, the second floater is used for triggering the first water level sensor or the second water level sensor, and the third floater is used for triggering the third water level sensor;
Or alternatively, the process may be performed,
the first floater is used for triggering the fourth water level sensor or the second water level sensor, the second floater is used for triggering the first water level sensor, and the third floater is used for triggering the third water level sensor;
or alternatively, the process may be performed,
the first floater is used for triggering the fourth water level sensor, the second floater is used for triggering the second water level sensor, and the third floater is used for triggering the first water level sensor or the third water level sensor.
11. The sample analysis device according to claim 9, wherein the trigger float includes a fourth float, a fifth float, a sixth float, and a seventh float, which are sequentially disposed from top to bottom by a connecting rod; the fourth floater is used for triggering the fourth water level sensor, the fifth floater is used for triggering the second water level sensor, the sixth floater is used for triggering the first water level sensor, and the seventh floater is used for triggering the third water level sensor.
12. The sample analysis device according to claim 9, wherein the trigger float includes an eighth float and a ninth float, which are disposed in order from top to bottom by a connecting rod; the eighth float is used for triggering the fourth water level sensor or the second water level sensor, and the ninth float is used for triggering the first water level sensor or the third water level sensor.
13. A method of controlling a sample analyzer, the method comprising:
acquiring the water inlet temperature detected by a temperature sensor of a liquid inlet of a water tank of the sample analysis device;
when the water inlet temperature is smaller than a preset temperature value, preset operation is executed to reduce the water inlet amount of unit time entering the water tank from the liquid inlet.
14. The control method according to claim 13, wherein the liquid inlet is connected with a water inlet pipe, the water inlet pipe is provided with a water inlet valve, and the water inlet valve is connected with the water inlet pipe of the liquid inlet; the preset operation includes at least one of:
controlling the intermittent opening of the water inlet valve;
and reducing the opening degree of the water inlet valve.
CN202111453536.5A 2021-11-30 2021-11-30 Sample analyzer and control method thereof Pending CN116203258A (en)

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CN202111453536.5A CN116203258A (en) 2021-11-30 2021-11-30 Sample analyzer and control method thereof

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Application Number Priority Date Filing Date Title
CN202111453536.5A CN116203258A (en) 2021-11-30 2021-11-30 Sample analyzer and control method thereof

Publications (1)

Publication Number Publication Date
CN116203258A true CN116203258A (en) 2023-06-02

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CN202111453536.5A Pending CN116203258A (en) 2021-11-30 2021-11-30 Sample analyzer and control method thereof

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