CN116203232A - Reagent card incubation device and immunochromatography analyzer - Google Patents

Reagent card incubation device and immunochromatography analyzer Download PDF

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Publication number
CN116203232A
CN116203232A CN202211731869.4A CN202211731869A CN116203232A CN 116203232 A CN116203232 A CN 116203232A CN 202211731869 A CN202211731869 A CN 202211731869A CN 116203232 A CN116203232 A CN 116203232A
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card
incubation
reagent card
reagent
assembly
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李署程
丁磊
蔡建雄
阳交凤
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Shanghai I Reader Biological Technology Co ltd
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Shanghai I Reader Biological Technology Co ltd
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    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/558Immunoassay; Biospecific binding assay; Materials therefor using diffusion or migration of antigen or antibody
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/5302Apparatus specially adapted for immunological test procedures
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02ATECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
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  • Chemical & Material Sciences (AREA)
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  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)

Abstract

The application discloses reagent card incubation device and immunochromatography analysis appearance relates to medical detection instrument technical field, and the reagent card of this application incubates the device, including the base, set up incubation dish, drive assembly and the card subassembly that moves of being connected with drive assembly on the base, along incubating radial a plurality of slots that are provided with of dish on the incubation dish, drive assembly drive moves the card subassembly and shifts reagent card between a plurality of slots to unload the card in a slot department wherein. The reagent card incubation device and the immunochromatography analyzer can simplify the structure of the incubation device and improve the flux of the immunochromatography analyzer.

Description

Reagent card incubation device and immunochromatography analyzer
Technical Field
The application relates to the technical field of medical detection instruments, in particular to a reagent card incubation device and an immunochromatography analyzer.
Background
The immunochromatography analysis is a unique immunoassay mode which appears in the early 80 s, and usually takes strip fiber chromatographic materials as solid phases, causes sample solutions to swim on chromatographic strips through capillary action, simultaneously causes high-specificity and high-affinity immune reaction between an object to be detected in the sample and receptors (such as antibodies or antigens) aiming at the object to be detected on the chromatographic materials, enriches or entraps immune complexes in certain areas (detection bands) of the chromatographic materials in the chromatography process, obtains visual experimental phenomena (such as color development) through enzyme reaction or directly using visually detectable markers (such as colloidal gold), and enables free markers to cross the detection bands so as to achieve the aim of automatic separation from bound markers. The analysis technology is simple and quick to operate, the analysis result is clear and easy to judge, so that the method is very suitable for the application of hospitals, families or individuals at all levels in the aspects of diagnosis, health care, physical examination and the like.
The automatic multichannel immunochromatographic analyzer in the prior art can complete incubation tests of multiple samples and multiple items simultaneously, and specifically comprises an incubation device, a dropping device and a detection device, wherein the dropping device and the detection device are arranged on the incubation device, a plurality of reagent cards are arranged on the incubation device, the reagent cards are arranged in the installation groove, the incubation device is used for dropping the reagent cards in a rotating process, the detection device is used for detecting the dropping liquid and incubating the reagent cards after preset time, after detection is completed, a special card unloading assembly is needed to push out the reagent cards, so that the incubation device is complex in structure and occupies a larger space, the card pushing time is needed to be reserved, detection of the next reagent card can be carried out, the detection efficiency of the chromatographic analyzer is reduced, and the flux of the immunochromatographic analyzer is reduced.
Disclosure of Invention
The purpose of the present application is to provide a reagent card incubation device and an immunochromatographic analyzer, which can simplify the structure of the reagent card incubation device and improve the throughput of the immunochromatographic analyzer.
The embodiment of the application provides a reagent card incubation device on the one hand, including the base, set up incubation dish, drive assembly and the card subassembly that moves of being connected with drive assembly on the base, incubation is provided with a plurality of slots along the radial of incubating the dish on the dish, and drive assembly drive moves the card subassembly and shifts reagent card between a plurality of slots to unload the card in one of them slot department.
As an implementation mode, move card subassembly and include with incubating the coaxial nested carousel of dish to and the pivot of being connected with the carousel, the pivot is connected with drive assembly in order to drive the carousel rotation under drive assembly's drive, is provided with the screens of prestoring along the radial of carousel on the carousel, and fixedly on the carousel is provided with the driving piece, when the screens of prestoring are the same with the groove extension direction, the reagent card of driving piece drive is transferred between prestoring screens and groove.
As an implementation manner, the driving member is further used for pushing the reagent card positioned in the fixed slot to move out from the other end of the fixed slot to realize card unloading when transferring one reagent card to one fixed slot.
As an implementation mode, the groove is arranged on one side of the incubation plate close to the base, the card moving component is arranged in the base, and the driving component is arranged on one side of the incubation plate far away from the base.
As an implementation mode, the driving piece drives the reagent card through the card pushing piece arranged on the turntable, push rods extending into the pre-stored card positions are arranged at two ends of the card pushing piece along the extending direction of the pre-stored card positions, and the card pushing piece is driven to drive the push rods at two ends to push the reagent card to enter the pre-stored card positions from one slot position or to enter the other slot position from the pre-stored card positions.
As an implementation mode, a first photoelectric detector facing the card pushing piece is arranged on the rotary table and used for sensing the position of the card pushing piece relative to the rotary table, and a second photoelectric detector is arranged in the pre-stored card position and used for sensing the state of the pre-stored card position.
As an implementation manner, the driving assembly comprises an encoder motor, a rotating shaft of the encoder motor is connected with the rotating shaft through a synchronous pulley, a bearing seat is arranged on one side surface of the incubation plate, which is far away from the base, and the rotating shaft penetrates through the bearing seat and is connected with the synchronous pulley.
As an implementation mode, the base comprises a shell, the shell is connected with the incubation plate to form a constant temperature chamber, the reagent card incubation device further comprises a temperature control component, the temperature control component comprises a controller, a temperature sensor arranged at the position of the groove and a heating component arranged in the constant temperature chamber, and the controller controls the heating component according to temperature information of the temperature sensor so that the position of the groove is in a preset temperature range.
As an implementation manner, the heating component comprises a heating plate and a heat conducting plate between the heating plate and the card moving component, and the heat conducting plate is made of high heat conducting material.
The embodiment of the application on the other hand provides an immunochromatography analyzer, including the frame, set up in above-mentioned reagent card in the frame incubate the device and set up in drip subassembly and the detection component in the frame, drip subassembly with the detection component is located the reagent card incubates the device incubate the dish top, be used for respectively right the reagent card in the incubation dish carries out drip and detects.
The beneficial effects of the embodiment of the application include:
the utility model provides a reagent card incubation device, including the base, set up the incubation dish on the base, drive assembly and move the card subassembly with drive assembly connection, it is provided with a plurality of slots along the radial of incubation dish to incubate on the dish, drive assembly drive moves the card subassembly and shifts reagent card between a plurality of operating slots, and unload the card in a slot department wherein, drive assembly drive moves the card subassembly and shifts reagent card between each slot, accomplish the dropping liquid of reagent card, incubate, detect and unload the card, because the card subassembly that moves of this application embodiment is when realizing shifting the reagent card, can also realize detecting the uninstallation of the reagent card of accomplishing, like this can simplify the structure of reagent card incubation device, and realize the pushing away of reagent card when shifting the reagent card, thereby improve immunochromatography analyzer's flux.
Drawings
In order to more clearly illustrate the technical solutions of the embodiments of the present application, the drawings that are needed in the embodiments will be briefly described below, it being understood that the following drawings only illustrate some embodiments of the present application and therefore should not be considered limiting the scope, and that other related drawings may be obtained according to these drawings without inventive effort for a person skilled in the art.
Fig. 1 is a schematic structural diagram of a reagent card incubation device according to an embodiment of the present disclosure;
fig. 2 is an exploded schematic view of a reagent card incubation device according to an embodiment of the present disclosure;
fig. 3 is a schematic structural diagram of an incubation plate according to an embodiment of the present disclosure;
FIG. 4 is a second schematic view of an incubation plate according to an embodiment of the present disclosure;
fig. 5 is a schematic structural diagram of a card moving assembly according to an embodiment of the present application;
fig. 6 is a schematic structural diagram of a driving assembly according to an embodiment of the present application;
fig. 7 is a schematic structural diagram of a heating assembly according to an embodiment of the present application.
Icon: 10-reagent card incubation device; 11-a base; 12-incubation plate; 121-slot position; 122-temporary storage; 123-drip level; 124-detecting bits; 125-incubation site; 13-a drive assembly; 14-card moving assembly; 141-a rotating shaft; 142-a turntable; 143-pre-storing clamping positions; 144-a driver; 145-pushing the clamping piece; 146-push rod; 15-bearing seats; 16-a barrier; 18-a heating assembly; 181-heating plate; 182-a heat-conducting plate; 183-heat sink assembly; 19-temperature sensor.
Detailed Description
For the purposes of making the objects, technical solutions and advantages of the embodiments of the present application more clear, the technical solutions of the embodiments of the present application will be clearly and completely described below with reference to the drawings in the embodiments of the present application, and it is apparent that the described embodiments are some embodiments of the present application, but not all embodiments. The components of the embodiments of the present application, which are generally described and illustrated in the figures herein, may be arranged and designed in a wide variety of different configurations.
Thus, the following detailed description of the embodiments of the present application, as provided in the accompanying drawings, is not intended to limit the scope of the application, as claimed, but is merely representative of selected embodiments of the application. All other embodiments, which can be made by one of ordinary skill in the art based on the embodiments herein without making any inventive effort, are intended to be within the scope of the present application.
It should be noted that: like reference numerals and letters denote like items in the following figures, and thus once an item is defined in one figure, no further definition or explanation thereof is necessary in the following figures.
In the description of the present application, it should be noted that, the terms "center," "vertical," "horizontal," "inner," "outer," and the like indicate an azimuth or a positional relationship based on that shown in the drawings, or an azimuth or a positional relationship that a product of the application is conventionally put in use, merely for convenience of describing the present application and simplifying the description, and do not indicate or imply that the apparatus or element to be referred to must have a specific azimuth, be configured and operated in a specific azimuth, and thus should not be construed as limiting the present application. Furthermore, the terms "first," "second," "third," and the like are used merely to distinguish between descriptions and should not be construed as indicating or implying relative importance.
The application provides a reagent card incubation device 10, as shown in fig. 1 and 2, including base 11, set up incubation dish 12, drive assembly 13 and the card subassembly 14 that moves of being connected with drive assembly 13 on base 11, be provided with a plurality of slots 121 along the radial of incubation dish 12 on the incubation dish 12, drive assembly 13 drive move card subassembly 14 with reagent card shift between a plurality of slots 121 to one of them slot 121 department unloads the card.
The reagent card incubation device 10 provided by the embodiment of the application is applied to an immunochromatography analyzer, a reagent card storage area of the immunochromatography analyzer pushes a reagent card into the reagent card incubation device 10, the reagent card is dripped into the reagent card incubation device 10, the reaction liquid is dripped into the reagent card, then the reaction liquid reacts with an antigen antibody on the reagent card in a constant-temperature incubation environment, and then the reacted reagent card is detected. According to the working principle of the reagent card incubation device 10, the slot 121 in the embodiment of the present application may be divided into a temporary storage position 122, a dripping level 123, an incubation position 125 and a detection position 124, where the temporary storage position 122 is used for storing a reagent card pushed by a reagent card storage area, the dripping level 123 is used for placing a reagent card requiring dripping, the incubation position 125 is used for placing a reagent card incubated after the dripping is completed, and the detection position 124 is used for detecting the reagent card after the incubation is completed. Since a certain time is required for the reaction solution to react with the antigen-antibody on the reagent card (i.e., incubate), a plurality of incubation sites 125 may be provided.
The reagent card incubation device 10 provided by the embodiment of the application is in operation, the temporary storage position 122 receives the reagent card from the reagent card storage area, the driving component 13 drives the card moving component 14 to move to the temporary storage position 122, the card moving component 14 takes the reagent card positioned at the temporary storage position 122 and moves to the dripping level 123 under the driving of the driving component 13, the above steps are repeated after the dripping is finished to transfer the reagent card to the incubation position 125, the above steps are repeated after the incubation is finished to transfer the reagent card to the detection position 124, and the card moving component 14 realizes the unloading of the reagent card at the detection position 124 after the detection is finished. The card moving assembly 14 in the embodiment of the application can realize the transfer of the reagent card and the unloading of the reagent card after the detection, so that the structure of the reagent card incubation device 10 can be simplified, and the card pushing of the reagent card can be realized while the reagent card is transferred, thereby improving the flux of the immunochromatographic analyzer. Here, the flux refers to the number of reagent card tests performed within a certain fixed time, and corresponds to the test efficiency of the reagent card incubation apparatus 10.
It should be noted that, because a certain time is required for incubation, after the card transferring assembly 14 transfers the first reagent card to the incubation position 125, the next reagent card may be dripped and transferred to the incubation position 125, until the incubation position 125 is completely placed with the incubated reagent card in sequence, and after the incubation of the first reagent card is completed, the first reagent card is detected and unloaded.
The application provides a reagent card incubation device 10, including base 11, set up incubation dish 12 on base 11, drive assembly 13 and move the card subassembly 14 with drive assembly 13 connection, be provided with a plurality of slots 121 along the radial of incubation dish 12 on incubating dish 12, drive assembly 13 drive moves the card subassembly 14 and shifts reagent card between a plurality of slots 121, and unload the card in one of them slot 121 department, drive assembly 13 drive moves card subassembly 14 and shifts reagent card between each slot 121, accomplish the dropping of reagent card, incubate, detect and unload the card, because the card subassembly 14 that moves of this application embodiment can also realize detecting the uninstallation of finished reagent card when realizing shifting the reagent card, like this can simplify the structure that the reagent card incubated device 10, and realize the pushing away of reagent card when shifting the reagent card, thereby improve immunochromatography analyzer's flux.
Alternatively, as shown in fig. 2 and 5, the card moving assembly 14 includes a rotary disc 142 coaxial with the incubation disc 12 and sleeved with the incubation disc 12, and a rotary shaft 141 connected with the rotary disc 142, where the rotary shaft 141 is connected with the driving assembly 13 to drive the rotary disc 142 to rotate under the driving of the driving assembly 13, a pre-storing clamping position 143 is arranged on the rotary disc 142 along the radial direction of the rotary disc 142, and a driving member 144 is fixedly arranged on the rotary disc 142, and when the pre-storing clamping position 143 is the same as the extending direction of the slot 121, the driving member 144 drives the reagent card to move between the pre-storing clamping position 143 and the slot 121.
The card moving assembly 14 comprises a rotary table 142 which is coaxial with the incubation tray 12 and sleeved with the incubation tray 12, and the rotary table 142 and the incubation tray 12 are arranged in a coplanar mode, so that a pre-stored clamping position 143 and a groove 121 are located at the same height, a rotary shaft 141 is connected with a driving piece 144, the driving piece 144 drives the rotary shaft 141 to rotate, the rotary table 142 is driven to rotate, and when the rotary table 142 is in the same extension direction of the pre-stored clamping position 143 and one groove 121, the driving piece 144 drives a reagent card to be transferred between the pre-stored clamping position 143 and the groove 121.
Specifically, the driving component 13 drives the rotating shaft 141 to rotate and drives the turntable 142 to rotate, so that when the extending direction of the pre-storing clamping position 143 and the extending direction of the temporary storing position 122 are the same, the driving piece 144 drives the reagent card to be transferred from the temporary storing position 122 to the pre-storing clamping position 143, then the turntable 142 rotates under the driving of the driving component 13, so that the extending direction of the pre-storing clamping position 143 and the dripping level 123 is the same, the driving piece 144 drives the reagent card to be transferred from the pre-storing clamping position 143 to the dripping level 123 to finish the transfer from the temporary storing position 122 to the dripping level 123, and the transfer from the dripping level 123 to the incubating position 125 to the detecting position 124 is finished.
In order to simplify the structure of the reagent card incubation apparatus 10, the incubation plate 12 is configured in a ring shape, and the turntable 142 is disposed in an area surrounded by the ring shape, as shown in fig. 2 and 3.
In one implementation of this embodiment, the driving member 144 is further configured to push the reagent card located in the fixing slot 121 out of the other end of the fixing slot 121 to remove the card when transferring the reagent card to the fixing slot 121.
The fixed slot 121 is a slot 121, and in order to improve the detection flux of the reagent card incubation apparatus 10, after detection is completed, the card is directly unloaded from the detection position 124, that is, the fixed slot 121 is the detection position 124, after the detection of the first reagent card is completed, the first reagent card is placed in the detection position 124, until the incubation of the second reagent card is completed, when the second reagent card is transferred to the detection position 124, the front end of the second reagent card will abut against the rear end of the first reagent card, and in the process of transferring the second reagent card, the first reagent card gradually exits from the other end of the detection position 124 from the detection position 124, thereby realizing the unloading of the first reagent card. According to the embodiment of the application, the second reagent card is adopted to push the first reagent card to realize the card unloading of the first reagent card, so that a card unloading assembly in the prior art can be reduced, the components of the reagent card incubation device 10 are reduced, the structure of the reagent card incubation device 10 is simplified, meanwhile, the card unloading time is not required to be reserved, the detection time of the reagent card is shortened, and the flux of an immunochromatography analyzer is improved.
Alternatively, as shown in fig. 2, the slot 121 is disposed on a side of the incubation plate 12 near the base 11, the card moving assembly 14 is disposed inside the base 11, and the driving assembly 13 is disposed on a side of the incubation plate 12 far from the base 11.
In practical applications, the base 11 is usually disposed on a rack of an immunochromatographic analyzer, so that one side of the incubation tray 12 where the slot 121 is disposed is downward, the card moving assembly 14 must be disposed inside the base 11 to implement a function of transferring a reagent card, and the driving assembly 13 is disposed on the other side of the incubation tray 12 due to limited space inside the base 11, so as to implement effective utilization of space and reduce space occupied by the reagent card incubation device 10.
As can be seen from the above, the side of the incubation plate 12 with the groove 121 is downward, so that the reagent card is prevented from falling under the action of gravity. In addition, a limiting portion may be formed by protruding from two sides of one side of the slot 121 near the base 11 toward the center, and a sliding channel between the two limiting portions is used for making the card moving assembly 14 move the card, where the limiting portion limits the reagent card in the vertical direction.
In one implementation manner of the embodiment of the present application, as shown in fig. 5, the driving member 144 drives the reagent card through the card pushing member 145 disposed on the turntable 142, the card pushing member 145 is provided with push rods 146 extending into the pre-stored card 143 along two ends of the extending direction of the pre-stored card 143, and the card pushing member 145 is driven to drive the push rods 146 at two ends to push the reagent card to enter the pre-stored card 143 from one slot 121 or to enter another slot 121 from the pre-stored card 143.
Specifically, when the extending direction of the pre-storing position 143 is the same as that of the temporary storing position 122, at this time, the push rod 146 of the push card 145 away from the center of the disc abuts against the outer side wall of the reagent card in the temporary storing position 122, the driving member 144 drives the push card 145 to move from the temporary storing position 122 to the pre-storing position, so that the push rod 146 drives the reagent card to move into the pre-storing position 143 when moving inwards, the reagent card is transferred from the temporary storing position 122 to the pre-storing position 143, at this time, the push card 145 returns to the starting point, then the turntable 142 rotates under the driving of the driving assembly 13, so that the extending direction of the pre-storing position 143 is the same as that of the dripping position 123, at this time, the push rod 146 of the push card 145 close to the center of the disc abuts against the inner side wall of the reagent card in the temporary storing position 122, and the driving member 144 drives the push card 145 to move outwards again, so that the push rod 146 drives the reagent card to move into the dripping position 123 when moving outwards, and the reagent card is transferred from the pre-storing position 143 to the dripping position 123, so that the transfer of the temporary storing position 122 to the dripping position 123 is completed, and the transfer of the dripping position 123 to the incubating position 125 is completed, and the transfer of the incubating position 125 to the detecting position 124 is completed.
Because of the long incubation time of the reagent card, after the reagent card is transferred from the dripping level 123 to the incubation position 125, the driving member 144 drives the card pushing member 145 to return to the zero position along the circumferential movement of the incubation plate, and then other reagent cards are transferred.
Optionally, as shown in fig. 5, a first photo detector facing the card pushing member 145 is disposed on the turntable 142, for sensing a position of the card pushing member 145 relative to the turntable 142, and a second photo detector is disposed in the pre-storing position 143, for sensing a state of the pre-storing position 143.
The first photoelectric detector is used for sensing the position of the push-clamping piece 145 relative to the turntable 142, and as can be seen from the above, the push-clamping piece 145 is used for transferring the reagent card from the pre-stored clamping position 143 to the groove position 121, or transferring the reagent card from the groove position 121 to the pre-stored clamping position 143, so that the push-clamping piece 145 has two positions relative to the turntable 142, one is a starting point position close to the turntable 142, and the other is a final point position far from the turntable 142, and the first photoelectric detector is used for sensing whether the push-clamping piece 145 is located at the starting point position or the final point position, thereby being capable of instantly judging the state of the push-clamping piece 145 and improving the working efficiency of the push-clamping piece 145. In order to detect two states of the card pushing member 145, the first photo detector includes two photo detectors, which are respectively used for detecting a start point position and an end point position, so as to accurately determine the position state of the card pushing member 145.
The second photoelectric detector is arranged in the pre-stored clamping position 143 and is used for sensing whether the pre-stored clamping position 143 contains a reagent card or not so as to judge the state in the pre-stored clamping position 143 in real time.
The card moving assembly 14 includes a plurality of elements, the elements need to be electrically connected and/or signal connected with the outside, in order to form a wiring channel, the inside of the rotating shaft can be set to be hollow, and the power lines and/or signal lines of the elements pass through the hollow of the rotating shaft to realize the electrical connection and/or signal connection.
In one implementation manner of the embodiment of the present application, as shown in fig. 1 and 6, the driving assembly 13 includes an encoder motor, a rotation shaft of the encoder motor is connected with the rotation shaft 141 through a synchronous pulley, a bearing seat 15 is disposed on a side surface of the incubation plate 12 far away from the base 11, and the rotation shaft 141 passes through the bearing seat 15 and is connected with the synchronous pulley.
When the drive assembly 13 includes an encoder motor, the positioning of the turntable 142 can be performed without repeated changes, thereby reducing reagent card transfer time, further improving reagent card detection efficiency, and improving the detection throughput of the reagent card incubation apparatus 10.
The encoder motor and the turntable 142 are arranged in a staggered manner through the synchronizing wheel, a frame body is arranged on the incubation plate 12 to fix the encoder motor, in addition, in order to fix the turntable 142, a fixing plate is arranged, the fixing plate is simultaneously connected with the turntable 142 and the incubation plate 12, and a bearing seat 15 is arranged on the fixing plate to support the synchronizing wheel.
Alternatively, as shown in fig. 4, the slot 121 includes a plurality of temporary storage locations 122, a drip level 123, a detection location 124, and a plurality of incubation locations 125, where the drip level 123 and the incubation locations 125 are provided with a blocking portion 16 at an end remote from the center of the incubation tray 12.
Because the drip level 123 and the detection level 124 are used for drip and detection, respectively, the operation time is short, and the incubation level 125 is used for incubation, which requires a long time, the embodiment of the present application sets the slot 121 to a plurality of temporary storage levels 122, one drip level 123, one detection level 124 and a plurality of incubation levels 125.
The temporary storage position 122 and the detection position 124 need to enter the card from one end of the slot position 121 and unload the card from the other side of the slot position 121, so the slot position 121 of the temporary storage position 122 and the detection position 124 is a through slot, the drop level 123 and the incubation position 125 need to enter the card from one end and take the card from the same end, so, in order to avoid that the reagent card slides out of the drop level 123 and the incubation position 125 from one end of the drop level 123 and the incubation position 125 far away from the center of the incubation plate 12, the blocking part 16 is arranged at one end of the drop level 123 and the incubation position 125 far away from the center of the incubation plate 12, so as to avoid the sliding out of the reagent card.
The number of the temporary storage sites 122 and the incubation sites 125 is not specifically limited in this embodiment, and a person skilled in the art can set according to actual incubation conditions and incubation time, and, in addition, the temporary storage sites 122 and the incubation sites 125 are used for placing reagent cards, so that when the incubation sites 125 are not enough in practical use, incubation in the temporary storage sites 122 can be adopted.
In addition, in order to further limit the dripping level 123 and the incubation position 125, the widths of the dripping level 123 and the incubation position 125 of the groove 121 can be set smaller, so long as the reagent card can be ensured to smoothly enter, on one hand, the reagent card can be prevented from sliding out, and the position of the reagent card can be accurately limited, because the dripping level 123 needs to drip the reagent card into the reaction liquid, the consistency of the dripping position can be ensured by accurately determining the reagent card; similarly, the detection bit 124 needs to scan and detect the reagent card, and the accurate positioning of the reagent card can ensure the detection accuracy.
In one implementation manner of the embodiment of the application, as shown in fig. 2 and 7, the base 11 includes a housing, the housing is connected with the incubation tray 12 to form a constant temperature chamber, the reagent card incubation device 10 further includes a temperature control assembly, the temperature control assembly includes a controller, a temperature sensor 19 disposed at the slot 121, and a heating assembly 18 disposed in the constant temperature chamber, and the controller controls the heating assembly 18 according to temperature information of the temperature sensor 19 so that the slot 121 is in a preset temperature range.
The constant temperature is favorable to the incubation of reagent card, through control by temperature change subassembly and controller for the temperature in the constant temperature cavity is in the default range, provides good temperature environment for the incubation of reagent card.
The number of the temperature sensors 19 is not limited in this embodiment, one may be set at one incubation position 125, one may be set at each incubation position 125, and the temperature sensors 19 may be set at the drip level 123, the incubation position 125, and the detection position 124, which may bring about cost increase and control difficulty in consideration of the number of the temperature sensors 19.
Alternatively, as shown in fig. 7, the heating assembly 18 includes a heating plate 181 and a heat conducting plate 182 between the heating plate 181 and the card moving assembly 14, and the heat conducting plate 182 is made of a high heat conducting material.
The heat conducting plate 182 can homogenize the heat generated by the heating plate, so that the temperature in the constant temperature chamber is uniform, and the problem that the incubation time cannot be controlled due to the fact that the temperature difference of the constant temperature chamber is large is avoided. In addition, the heat conducting plate 182 made of high heat conducting material can transfer heat quickly, so that the temperature in the constant temperature chamber reaches the preset temperature range quickly after the power-on.
In one implementation manner of the embodiment of the present application, as shown in fig. 7, the heating plate 181 is a semiconductor heating plate, and the cooling surface of the semiconductor heating plate is further connected to a heat dissipation component 183, where the heat dissipation component 183 passes through the housing and is communicated with the outside.
The heat dissipation assembly 183 can rapidly dissipate cold air of the cooling surface of the semiconductor heating sheet, thereby increasing the heating speed of the heating surface of the semiconductor heating sheet and reaching a preset temperature in a short time.
Specifically, the heat dissipation assembly 183 includes a heat dissipation fin attached to the cooling surface of the semiconductor heating fin 181, and a heat dissipation air channel, where the heat dissipation fin is disposed at one end of the heat dissipation air channel, and a heat dissipation fan is disposed at the other end of the heat dissipation air channel. The cooling fan can accelerate the air flow in the cooling air duct, and the cooling efficiency is improved.
The embodiment of the application also discloses immunochromatography analyzer, including the frame, set up in above-mentioned reagent card in the frame incubate device 10 and set up in drip subassembly and the detection component in the frame, drip subassembly with the detection component is located the incubation dish 12 top of reagent card incubation device 10 is used for respectively right reagent card in the incubation dish 12 carries out drip and detects. The immunochromatographic assay contains the same structure and advantageous effects as those of the reagent card incubation device 10 in the foregoing embodiment. The structure and advantages of the reagent card incubation apparatus 10 have been described in detail in the previous embodiments, and are not described here again.
The foregoing description is only of the preferred embodiments of the present application and is not intended to limit the same, but rather, various modifications and variations may be made by those skilled in the art. Any modification, equivalent replacement, improvement, etc. made within the spirit and principles of the present application should be included in the protection scope of the present application.

Claims (10)

1. The utility model provides a reagent card incubation device, its characterized in that includes the base, set up in incubation dish, drive assembly on the base and with drive assembly is connected move the card subassembly, incubation is gone up along the radial of incubation dish is provided with a plurality of slots, drive assembly drive moves the card subassembly with reagent card a plurality of shift between the slot and one of them slot department unloads the card.
2. The reagent card incubation device according to claim 1, wherein the card moving assembly comprises a rotary table coaxially nested with the incubation plate, and a rotary shaft connected with the rotary table, the rotary shaft is connected with the driving assembly to drive the rotary table to rotate under the driving of the driving assembly, a pre-storing clamping position is arranged on the rotary table along the radial direction of the rotary table, and a driving piece is fixedly arranged on the rotary table, and when the pre-storing clamping position is identical to the extending direction of the slot position, the driving piece drives the reagent card to be transferred between the pre-storing clamping position and the slot position.
3. A reagent card incubation apparatus according to claim 2 wherein the drive means is further adapted to urge a reagent card located in a fixed slot to move out of the other end of the fixed slot to effect card removal when transferring one of the reagent cards to the fixed slot.
4. The reagent card incubation device of claim 2, wherein the slot is disposed on a side of the incubation plate adjacent to the base, the card moving assembly is disposed inside the base, and the driving assembly is disposed on a side of the incubation plate away from the base.
5. The reagent card incubating apparatus according to claim 2, wherein the driving member drives the reagent card through a card pushing member provided on the turntable, push rods extending into the pre-stored card positions are provided at both ends of the card pushing member along the extending direction of the pre-stored card positions, and the push rods at both ends of the card pushing member are driven to push the reagent card from one of the slots into the pre-stored card position or from the pre-stored card position into the other slot.
6. The reagent card incubation device according to claim 5, wherein the turntable is provided with a first photoelectric detector facing the card pushing member for sensing a position of the card pushing member relative to the turntable, and a second photoelectric detector is arranged in the pre-stored card position for sensing a state of the pre-stored card position.
7. The reagent card incubating apparatus according to claim 2, wherein the driving assembly comprises an encoder motor, a rotating shaft of the encoder motor is connected with the rotating shaft through a synchronous pulley, a bearing seat is arranged on a side surface of the incubating disc, which is far away from the base, and the rotating shaft passes through the bearing seat and is connected with the synchronous pulley.
8. The reagent card incubation device of claim 2, wherein the base comprises a housing connected to the incubation plate to form a constant temperature chamber, and further comprising a temperature control assembly comprising a controller, a temperature sensor disposed at the slot, and a heating assembly disposed in the constant temperature chamber, wherein the controller controls the heating assembly to maintain the slot within a predetermined temperature range based on temperature information from the temperature sensor.
9. The reagent card incubation apparatus of claim 8, wherein the heating assembly comprises a heating sheet and a thermally conductive plate between the heating sheet and the card moving assembly, the thermally conductive plate being made of a highly thermally conductive material.
10. An immunochromatographic analyzer, comprising a frame, a reagent card incubation device according to any one of claims 1 to 9 arranged on the frame, and a drip assembly and a detection assembly arranged on the frame, wherein the drip assembly and the detection assembly are positioned above an incubation tray of the reagent card incubation device and are used for respectively dripping and detecting reagent cards in the incubation tray.
CN202211731869.4A 2022-12-30 2022-12-30 Reagent card incubation device and immunochromatography analyzer Pending CN116203232A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN202211731869.4A CN116203232A (en) 2022-12-30 2022-12-30 Reagent card incubation device and immunochromatography analyzer

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN202211731869.4A CN116203232A (en) 2022-12-30 2022-12-30 Reagent card incubation device and immunochromatography analyzer

Publications (1)

Publication Number Publication Date
CN116203232A true CN116203232A (en) 2023-06-02

Family

ID=86512195

Family Applications (1)

Application Number Title Priority Date Filing Date
CN202211731869.4A Pending CN116203232A (en) 2022-12-30 2022-12-30 Reagent card incubation device and immunochromatography analyzer

Country Status (1)

Country Link
CN (1) CN116203232A (en)

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