CN116173415A - Transcranial magnetic stimulation system, device and medium for relieving anxiety - Google Patents
Transcranial magnetic stimulation system, device and medium for relieving anxiety Download PDFInfo
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Abstract
The embodiment of the invention discloses a transcranial magnetic stimulation system, equipment and medium for relieving anxiety. Wherein, the system includes: a brain region positioning device and a transcranial magnetic stimulation signal generating device; the brain region positioning device is used for determining the frontal lobe eye region of the target object; the transcranial magnetic stimulation signal generating device is used for applying an intermittent theta pulse stimulation sequence to the frontal lobe eye region. The technical scheme of the embodiment of the invention solves the problem of long duration of transcranial magnetic stimulation for relieving anxiety, can precisely act on frontal lobe brain regions, reduces the stimulation duration, and improves the efficiency of the transcranial magnetic stimulation for relieving anxiety.
Description
Technical Field
The embodiment of the invention relates to the technical field of transcranial magnetic stimulation, in particular to a transcranial magnetic stimulation system, equipment and medium for relieving anxiety.
Background
The effectiveness of transcranial magnetic stimulation to relieve anxiety is currently being improved by applying repeated transcranial magnetic stimulation (repeated transcranial magnetic stimulation, rTMS) to the dorsally-lateral prefrontal cortex (dorsolateral prefrontal cortex, dlPFC) for a period of 10-30 minutes.
Disclosure of Invention
The invention provides a transcranial magnetic stimulation system, equipment and medium for relieving anxiety, which solve the problem of long duration of transcranial magnetic stimulation for relieving anxiety, can precisely act on frontal lobe brain areas, reduce stimulation duration and improve the efficiency of the transcranial magnetic stimulation for relieving anxiety.
According to an aspect of the present invention, there is provided a transcranial magnetic stimulation system for alleviating anxiety, the system comprising:
a brain region positioning device and a transcranial magnetic stimulation signal generating device;
the brain region positioning device is used for determining the frontal lobe eye region of the target object;
the transcranial magnetic stimulation signal generating device is used for applying an intermittent theta pulse stimulation sequence to the frontal lobe eye region.
According to another aspect of the present invention, there is provided an electronic device including:
at least one processor; and
a memory communicatively coupled to the at least one processor; wherein,,
the memory stores a computer program executable by the at least one processor to enable the at least one processor to perform the functions of the brain region localization device or the transcranial magnetic stimulation signal generation device of any of the embodiments of the present invention.
According to another aspect of the present invention, there is provided a computer readable storage medium storing computer instructions for causing a processor to perform the functions of the brain region localization device or transcranial magnetic stimulation signal generation device of any of the embodiments of the present invention when executed.
According to the technical scheme provided by the embodiment of the invention, the frontal lobe eye area of the target object is determined through the brain area positioning device, and the transcranial magnetic stimulation signal generating device acts the intermittent theta pulse stimulation sequence on the frontal lobe eye area, so that the problem of long duration of transcranial magnetic stimulation for relieving anxiety is solved, the transcranial magnetic stimulation can be accurately acted on the frontal lobe brain area, the stimulation duration is reduced, and the anxiety relieving efficiency of transcranial magnetic stimulation is improved.
It should be understood that the description in this section is not intended to identify key or critical features of the embodiments of the invention or to delineate the scope of the invention. Other features of the present invention will become apparent from the description that follows.
Drawings
In order to more clearly illustrate the technical solutions of the embodiments of the present invention, the drawings required for the description of the embodiments will be briefly described below, and it is apparent that the drawings in the following description are only some embodiments of the present invention, and other drawings may be obtained according to these drawings without inventive effort for a person skilled in the art.
FIG. 1 is a block diagram of a transcranial magnetic stimulation system for alleviating anxiety according to an embodiment of the present invention;
fig. 2 is a block diagram of an electronic device according to an embodiment of the present invention.
Detailed Description
In order that those skilled in the art will better understand the present invention, a technical solution in the embodiments of the present invention will be clearly and completely described below with reference to the accompanying drawings in which it is apparent that the described embodiments are only some embodiments of the present invention, not all embodiments. All other embodiments, which can be made by those skilled in the art based on the embodiments of the present invention without making any inventive effort, shall fall within the scope of the present invention.
It is noted that the terms "comprises" and "comprising," and any variations thereof, in the description and claims of the present invention and in the foregoing figures, are intended to cover a non-exclusive inclusion, such that a process, method, system, article, or apparatus that comprises a list of steps or elements is not necessarily limited to those steps or elements expressly listed or inherent to such process, method, article, or apparatus.
Fig. 1 is a block diagram of a transcranial magnetic stimulation system for alleviating anxiety according to an embodiment of the present invention, where the present embodiment is applicable to a transcranial magnetic stimulation scenario, and in particular, the present embodiment is more applicable to a transcranial magnetic stimulation scenario for alleviating anxiety. The system may be implemented in software and/or hardware, integrated into an electronic device with application development functionality.
As shown in fig. 1, the system includes: a brain region positioning device 110 and a transcranial magnetic stimulation signal generating device 120.
Wherein the brain region positioning device 110 is used for determining the frontal lobe eye region of the target object.
Transcranial magnetic stimulation signal generation device 120 is used to apply an intermittent θ pulse stimulation sequence to the frontal eye region.
The target object is an object that is required to receive transcranial magnetic stimulation.
The frontal lobe eye region (frontal eye fields, FEF) is located in the posterior aspect of the frontal middle-back, controls voluntary eye movements, particularly related to the following movements of the eye, and participates in visual attention, also the brain region responsible for the individual's attention suppressing process.
Theta pulse is a form of rTMS, typically consisting of 3 pulses at 30Hz or 50Hz, repeated 5 times per second for a total of 600 pulses, divided into continuous theta pulse stimulation (continuous theta burst stimulation, cTBS) and intermittent theta pulse stimulation (intermittent theta burst stimulation, ittbs) according to the difference in stimulation parameters. The combination repetition of the stimulation sequence with the irbs of 2 seconds and the intermittent 8 seconds, applied to the brain at the affected side, can increase the excitability of the motor cortex; cTBS consists of 40 seconds of uninterrupted TBS, and application to the healthy side brain can reduce the excitability of the motor cortex.
Optionally, the transcranial magnetic stimulation signal generating device 120 is configured to: forming a cluster by using 3 continuous preset intensity pulses, wherein each 10 clusters are used as a group of theta pulse stimulation sequences, and outputting signals of a plurality of groups of pulse stimulation sequences; wherein, the pulse frequency in the cluster is 50Hz, and the pulse frequency between clusters is 5Hz.
Specifically, each group of θ pulse stimulation sequences for transcranial magnetic stimulation comprises 10 pulse bursts, each pulse burst comprises 3 pulses of preset intensity, the intra-burst pulse frequency is 50Hz, the inter-burst pulse frequency is 5Hz, the period of the intra-burst pulse is 20ms, and the period of the pulse bursts is 200ms.
The intensity of transcranial magnetic stimulation can be determined by resting motion threshold (resting motor threshold, RMT) or active motion threshold (active motor threshold, AMT).
The resting motor threshold value refers to the minimum stimulation intensity that at least 50% of stimulation in the continuous stimulation process induces a motor evoked potential with an amplitude exceeding 50 mu V, and is a neurophysiologic index reflecting cerebral cortex excitability, and the higher the resting motor threshold value is, the lower the cerebral cortex excitability is.
The motor threshold is the minimum stimulation intensity required to stimulate motor cortex using TMS to induce a target muscle (typically the extensor hallucis brevis) motor evoked potential (motor evoked potentials, MEP) with an amplitude exceeding 50 μv for at least 5 out of 10 stimulations, primarily for evaluation of cortical tract excitability. Wherein, MEP is a motor compound potential recorded by stimulating motor cortex on contralateral target muscle for checking the overall synchronicity and integrity of motor nerve transmission from cortex to muscle.
Optionally, the transcranial magnetic stimulation signal generating device 120 is configured to: pulse stimulation sequence signal output was performed for a total duration of 3 minutes with 8 seconds intervals between each set of theta pulse stimulation sequences.
Specifically, the transcranial magnetic stimulation signal generator 120 is caused to generate a signal that repeats in a combination of a stimulation sequence of 2 seconds and an 8 second interval for a total duration of 3 minutes by the parameters of the transcranial magnetic stimulation signal generator 120.
In a specific example, the parameter settings for the intermittent θ pulse stimulation sequence of transcranial magnetic stimulation are shown in table 1, where stimulation intensity is determined using AMT, stimulation intensity is 80% AMT, from an internal pulse frequency of 50Hz, 3 pulses within each cluster, an inter-cluster pulse frequency of 5Hz, a group of 10 clusters of stimulation, 10 groups of stimulation, cluster interval time of 8s, pulse number of 480, and total stimulation duration of 3min.
TABLE 1
Optionally, the brain region positioning device 110 includes: an infrared signal acquisition module and an infrared signal analysis module.
The infrared signal acquisition module is used for acquiring brain position information of the target object.
The brain position information is used to represent the head contour of the target object or the position of each brain region.
The infrared signal acquisition module acquires brain position information of the target object through the infrared sensor. The detection modes of the infrared sensor comprise three types of reflection type, correlation type and mirror reflection type. The infrared sensor can be divided into a level type and a pulse type according to different driving modes of infrared rays on the radiation tube; the photon detector based on photoelectric effect and the heat detector based on thermal effect can be classified according to the detection principle; the system can be divided into five main categories of radiometers, search tracking systems, thermal imaging systems, infrared ranging communication systems and hybrid systems according to different functions.
Specifically, the optical submodule of the infrared signal acquisition module receives infrared radiation of a target object, the infrared radiation energy distribution pattern is reflected to each photosensitive element of the infrared detector array on a focal plane through spectral filtering, the infrared radiation energy is converted into an electric signal by the detector, and a required amplified signal is output by the input circuit of detector bias and front amplification and is injected into the readout circuit so as to be multiplexed. The readout circuit of the CMOS (Complementary Metal Oxide Semiconductor ) multiplexer can perform signal integration, transmission, processing and scan output of the infrared focal plane arrays of the linear array and the planar array, and perform a/D conversion to obtain brain position information of the target object, and send the brain position information to the infrared signal analysis module.
The infrared signal analysis module is used for reconstructing according to the brain position information to obtain a three-dimensional head model, and determining frontal lobe eye areas based on the three-dimensional head model and the brain function area distribution information.
The brain function area distribution information is the distribution position of each functional brain area of the brain in the brain. Functional brain regions can be divided into four regions, frontal, parietal, occipital and temporal, according to the sulcus of the brain. Wherein the frontal lobe is responsible for thinking, planning, central executive function and athletic performance; the top leaf is responsible for integration of somatosensory perception, vision and body space information; the temporal lobe is mainly responsible for language function and auditory perception, and also participates in long-term memory and emotion; the occipital lobe is mainly responsible for visual perception and processing. The cerebral cortex can also be divided according to the brodman division into 52 regions including each hemisphere, some of which have now been subdivided, e.g., region 23 divided into regions 23a and 23b, etc. The same partition number does not necessarily represent similar brain regions between different species in terms of species-to-species differences. The frontal lobe eye area is located in zone 8.
Specifically, firstly, an infrared signal analysis module calculates the corresponding relation between an image coordinate system of an infrared signal acquisition device and a world coordinate system; then, reconstructing three-dimensional information by using the brain position information, and realizing D/A conversion of the brain position information of the target object to obtain a three-dimensional head model of the target object; finally, the position/coordinates of frontal lobe eye areas in the three-dimensional head model are determined according to the three-dimensional head model of the target object and the distribution of each functional brain area in the cerebral cortex division.
Optionally, the infrared signal analysis module is configured to: the functional brain region distribution positions in the brain functional region distribution information are mapped into the three-dimensional head model, and frontal lobe eye regions are determined based on the mapping result.
Specifically, the infrared signal analysis module corresponds the distribution positions of all the functional brain regions in the brain functional region distribution information to the three-dimensional head model of the target object to obtain the positions of all the functional brain regions in the three-dimensional head model, and the positions of the 8 regions in the three-dimensional head model are frontal lobe eye regions.
In order to provide interaction with the user, a display may also be provided in the system, as may other display means for displaying information, such as a CRT (cathode ray tube) or LCD (liquid crystal display) monitor, for displaying a three-dimensional head model of the target object.
Optionally, the system further comprises an electroencephalogram signal acquisition device, which is used for acquiring a first-stage electroencephalogram signal of the target object before receiving the transcranial magnetic stimulation signal and a second-stage electroencephalogram signal after receiving the transcranial magnetic stimulation signal, and comparing and analyzing the first-stage electroencephalogram signal and the second-stage electroencephalogram signal.
And performing brain wave signal contrast analysis by using an brain wave signal analysis method. The electroencephalogram signal analysis method comprises frequency domain analysis, time domain analysis, wavelet transformation, artificial neural network analysis, nonlinear dynamics analysis and the like. The frequency domain analysis method comprises the methods of power spectrum estimation, AR parameter model spectrum estimation, double spectrum analysis and the like; the time domain analysis is mainly used for directly extracting waveform characteristics, and comprises zero crossing intercept point analysis, histogram analysis, variance analysis, correlation analysis, peak detection, waveform parameter analysis, coherent average, waveform identification and other methods. The electroencephalogram signal is a time-varying non-stationary signal and has different frequency components at different times. The simple time domain analysis method and the frequency domain analysis method are related by Fourier transformation, and the clear separation of the time domain analysis method and the frequency domain analysis method is based on the premise that the frequency time-invariant characteristic or the statistical characteristic of the signal is stable. However, because of the "uncertainty principle" of the time domain and frequency domain resolutions, it is impossible to obtain higher resolution in both the time domain and the frequency domain, and only by combining time and frequency for processing, better results can be obtained. The time-frequency representation of signals is a development trend of electroencephalogram signal processing, and the currently applied and relatively wide methods are Wigner-Ferri distribution (Wigner-Ville Distribution, WD) and wavelet transformation.
It will be appreciated that a comparative analysis of the first phase and second phase brain wave signals is required for assessing the anxiety level of the target subject. Firstly, before transcranial magnetic stimulation begins, acquiring an electroencephalogram signal of a target object as a first-stage electroencephalogram signal; then, after the transcranial magnetic stimulation is finished, acquiring an electroencephalogram signal of the target object as an electroencephalogram signal of the second stage; finally, brain wave signal contrast analysis is carried out on the brain wave signals before and after stimulation by using an electroencephalogram signal analysis method.
Optionally, the system further comprises a questionnaire information collecting device, which is used for obtaining feedback information of the target object to a preset evaluation scale.
The evaluation scale is used for measuring the psychological scale of the anxiety state degree and the change condition of the target object in the treatment process, is used for evaluating the curative effect, and cannot be used for diagnosis. The user can adjust the setting of the evaluation scale according to the requirement, and also can directly use the anxiety Self-evaluation scale (Self-Rating Anxiety Scale, SAS) as the evaluation scale.
The feedback information may be the score or description content of the target object on each statistical index in the evaluation scale, and the anxiety level of the target object may be determined according to the mapping relationship between the feedback information and the anxiety level.
The specific mode of acquiring the feedback information of the preset evaluation scale can be that an interactive interface is displayed in a questionnaire information collecting device, the preset evaluation scale can be displayed in a filling interface of the interactive interface, and a target object is filled in, so that the feedback information of the target object on the preset evaluation scale can be acquired; the feedback information of the target object on the preset evaluation scale can be obtained by scanning the preset evaluation scale filled in by the target object of the paper version.
According to the technical scheme provided by the embodiment of the invention, the frontal lobe eye area of the target object is determined through the brain area positioning device, and the transcranial magnetic stimulation signal generating device acts the intermittent theta pulse stimulation sequence on the frontal lobe eye area, so that the problem of long duration of transcranial magnetic stimulation for relieving anxiety is solved, the transcranial magnetic stimulation can be accurately acted on the frontal lobe brain area, the stimulation duration is reduced, and the anxiety relieving efficiency of transcranial magnetic stimulation is improved.
Fig. 2 is a block diagram of an electronic device according to an embodiment of the present invention. The electronic device 10 is intended to represent various forms of digital computers, such as laptops, desktops, workstations, personal digital assistants, servers, blade servers, mainframes, or other appropriate computers. The electronic device may also represent various forms of mobile apparatus, such as personal digital processing, cellular telephones, smartphones, wearable devices (e.g., helmets, glasses, watches, etc.), or other similar computing devices. The components shown herein, their connection relationships, and their functions, are meant to be exemplary only, and are not meant to limit implementations of the invention described and/or claimed herein.
As shown in fig. 2, the electronic device 10 includes at least one processor 11, and a memory, such as a Read Only Memory (ROM) 12, a Random Access Memory (RAM) 13, etc., communicatively connected to the at least one processor 11, in which the memory stores a computer program executable by the at least one processor, and the processor 11 may perform various appropriate actions and processes according to the computer program stored in the Read Only Memory (ROM) 12 or the computer program loaded from the storage unit 18 into the Random Access Memory (RAM) 13. In the RAM 13, various programs and data required for the operation of the electronic device 10 may also be stored. The processor 11, the ROM 12 and the RAM 13 are connected to each other via a bus 14. An input/output (I/O) interface 15 is also connected to bus 14.
Various components in the electronic device 10 are connected to the I/O interface 15, including: an input unit 16 such as a keyboard or a mouse; an output unit 17 such as various types of displays or speakers, etc.; a storage unit 18 such as a magnetic disk or an optical disk; and a communication unit 19 such as a network card, modem or wireless communication transceiver, etc. The communication unit 19 allows the electronic device 10 to exchange information/data with other devices via a computer network, such as the internet, and/or various telecommunication networks.
The processor 11 may be a variety of general and/or special purpose processing components having processing and computing capabilities. Some examples of processor 11 include, but are not limited to, a Central Processing Unit (CPU), a Graphics Processing Unit (GPU), various specialized Artificial Intelligence (AI) computing chips, various processors running machine learning model algorithms, a Digital Signal Processor (DSP), any suitable processor, controller or microcontroller, and the like. The processor 11 performs the various functions and processes described above, such as the functions of the brain region locating device 110 or the transcranial magnetic stimulation signal generating device 120.
In some embodiments, the functionality of the brain region localization device 110 or the transcranial magnetic stimulation signal generation device 120 may be implemented as a computer program tangibly embodied on a computer readable storage medium, such as the storage unit 18. In some embodiments, part or all of the computer program may be loaded and/or installed onto the electronic device 10 via the ROM 12 and/or the communication unit 19. When the computer program is loaded into the RAM 13 and executed by the processor 11, the functions of the brain region positioning device 110 or the transcranial magnetic stimulation signal generating device 120 described above may be performed. Alternatively, in other embodiments, the processor 11 may be configured to perform the functions of the brain region localization device 110 or the transcranial magnetic stimulation signal generating device 120 in any other suitable manner (e.g., by means of firmware).
Various implementations of the systems and techniques described here above can be implemented in digital electronic circuitry, integrated circuit systems, field Programmable Gate Arrays (FPGAs), application Specific Integrated Circuits (ASICs), application Specific Standard Products (ASSPs), systems On Chip (SOCs), load programmable logic devices (CPLDs), computer hardware, firmware, software, and/or combinations thereof. These various embodiments may include: implemented in one or more computer programs, the one or more computer programs may be executed and/or interpreted on a programmable system including at least one programmable processor, which may be a special purpose or general-purpose programmable processor, that may receive data and instructions from, and transmit data and instructions to, a storage system, at least one input device, and at least one output device.
The computer program for implementing the functionality of the brain region localization device 110 or the transcranial magnetic stimulation signal generation device 120 of the present invention may be written in any combination of one or more programming languages. These computer programs may be provided to a processor of a general purpose computer, special purpose computer, or other programmable data processing apparatus, such that the computer programs, when executed by the processor, cause the functions/acts specified in the flowchart and/or block diagram block or blocks to be implemented. The computer program may execute entirely on the machine or partly on the machine, partly on the machine and partly on a remote machine or entirely on the remote machine or server as a stand-alone software package.
In the context of the present invention, a computer-readable storage medium may be a tangible medium that can contain, or store a computer program for use by or in connection with an instruction execution system, apparatus, or device. The computer readable storage medium may include, but is not limited to, an electronic, magnetic, optical, electromagnetic, infrared, or semiconductor system, apparatus, or device, or any suitable combination of the foregoing. Alternatively, the computer readable storage medium may be a machine readable signal medium. More specific examples of a machine-readable storage medium would include an electrical connection based on one or more wires, a portable computer diskette, a hard disk, a Random Access Memory (RAM), a read-only memory (ROM), an erasable programmable read-only memory (EPROM or flash memory), an optical fiber, a portable compact disc read-only memory (CD-ROM), an optical storage device, a magnetic storage device, or any suitable combination of the foregoing.
To provide for interaction with a user, the systems and techniques described here can be implemented on an electronic device having: a display device (e.g., CRT (Cathode Ray Tube) or LCD (Liquid Crystal Display ) monitor) for displaying information to a user; and a keyboard and a pointing device (e.g., a mouse or a trackball) through which a user can provide input to the electronic device. Other kinds of devices may also be used to provide for interaction with a user; for example, feedback provided to the user may be any form of sensory feedback (e.g., visual feedback, auditory feedback, or tactile feedback); and input from the user may be received in any form, including acoustic input, speech input, or tactile input.
The systems and techniques described here can be implemented in a computing system that includes a background component (e.g., as a data server), or that includes a middleware component (e.g., an application server), or that includes a front-end component (e.g., a user computer having a graphical user interface or a web browser through which a user can interact with an implementation of the systems and techniques described here), or any combination of such background, middleware, or front-end components. The components of the system can be interconnected by any form or medium of digital data communication (e.g., a communication network). Examples of communication networks include: local Area Networks (LANs), wide Area Networks (WANs), blockchain networks, and the internet.
The computing system may include clients and servers. The client and server are typically remote from each other and typically interact through a communication network. The relationship of client and server arises by virtue of computer programs running on the respective computers and having a client-server relationship to each other. The server can be a cloud server, also called a cloud computing server or a cloud host, and is a host product in a cloud computing service system, so that the defects of high management difficulty and weak service expansibility in the traditional physical hosts and VPS service are overcome.
It should be appreciated that various forms of the flows shown above may be used to reorder, add, or delete steps. For example, the steps described in the present invention may be performed in parallel, sequentially, or in a different order, so long as the desired results of the technical solution of the present invention are achieved, and the present invention is not limited herein.
The above embodiments do not limit the scope of the present invention. It will be apparent to those skilled in the art that various modifications, combinations, sub-combinations and alternatives are possible, depending on design requirements and other factors. Any modifications, equivalent substitutions and improvements made within the spirit and principles of the present invention should be included in the scope of the present invention.
Claims (9)
1. A transcranial magnetic stimulation system for relieving anxiety, comprising:
a brain region positioning device and a transcranial magnetic stimulation signal generating device;
wherein the brain region positioning device is used for determining the frontal lobe eye region of the target object;
the transcranial magnetic stimulation signal generating device is used for applying an intermittent theta pulse stimulation sequence to the frontal lobe eye region.
2. The system of claim 1, wherein the transcranial magnetic stimulation signal generation device is configured to:
forming a cluster by using 3 continuous preset intensity pulses, wherein each 10 clusters are used as a group of theta pulse stimulation sequences, and outputting signals of a plurality of groups of pulse stimulation sequences;
wherein the intra-cluster pulse frequency is 50Hz, and each inter-cluster pulse frequency is 5Hz.
3. The system of claim 2, wherein the transcranial magnetic stimulation signal generation device is configured to:
pulse stimulation sequence signal output was performed for a total duration of 3 minutes with 8 seconds intervals between each set of theta pulse stimulation sequences.
4. The system of claim 1, wherein the brain region locating device comprises: an infrared signal acquisition module and an infrared signal analysis module;
the infrared signal acquisition module is used for acquiring brain position information of the target object;
the infrared signal analysis module is used for reconstructing according to the brain position information to obtain a three-dimensional head model, and determining the frontal lobe eye area based on the three-dimensional head model and brain function area distribution information.
5. The system of claim 4, wherein the infrared signal analysis module is configured to:
mapping each functional brain region distribution position in the brain function region distribution information into the three-dimensional head model, and determining the frontal lobe eye region based on a mapping result.
6. The system according to claim 1, further comprising an electroencephalogram signal acquisition apparatus for acquiring a first-stage electroencephalogram signal of the target subject before receiving the transcranial magnetic stimulation signal and a second-stage electroencephalogram signal after receiving the transcranial magnetic stimulation signal, and performing a comparative analysis on the first-stage electroencephalogram signal and the second-stage electroencephalogram signal.
7. The system of claim 1, further comprising questionnaire information collection means for:
and acquiring feedback information of the target object on a preset evaluation scale.
8. An electronic device, the electronic device comprising:
at least one processor; and
a memory communicatively coupled to the at least one processor; wherein,,
the memory stores a computer program executable by the at least one processor to enable the at least one processor to perform the functions of the brain region localization device or the transcranial magnetic stimulation signal generation device according to any one of claims 1-7.
9. A computer readable storage medium, characterized in that the computer readable storage medium stores computer instructions for causing a processor to perform the functions of the brain region localization device or transcranial magnetic stimulation signal generation device according to any one of claims 1-7.
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| CN202211444504.3A CN116173415A (en) | 2022-11-18 | 2022-11-18 | Transcranial magnetic stimulation system, device and medium for relieving anxiety |
| PCT/CN2022/138171 WO2024103468A1 (en) | 2022-11-18 | 2022-12-09 | Transcranial magnetic stimulation system for relieving anxiety, device, and medium |
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| CN202211444504.3A CN116173415A (en) | 2022-11-18 | 2022-11-18 | Transcranial magnetic stimulation system, device and medium for relieving anxiety |
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| US20140058189A1 (en) * | 2012-02-20 | 2014-02-27 | William F. Stubbeman | Systems and methods using brain stimulation for treating disorders |
| CN102908145B (en) * | 2012-11-09 | 2015-01-21 | 中国科学院自动化研究所 | Brain region function positioning method based on multimode magnetic resonance imaging |
| CN109480841A (en) * | 2017-09-13 | 2019-03-19 | 复旦大学 | Abnormal brain area precise positioning and antidote based on functional mri |
| CN109481845B (en) * | 2018-12-28 | 2022-04-01 | 深圳先进技术研究院 | Method and related device for transcranial magnetic stimulation acting on different brain areas |
| CN112402800B (en) * | 2020-11-18 | 2024-09-24 | 中国科学院深圳先进技术研究院 | Visual search capability enhancement method and related device |
| CN113769275B (en) * | 2021-10-19 | 2022-10-04 | 南京伟思医疗科技股份有限公司 | Automatic positioning method and system for transcranial magnetic treatment target |
| CN114146315A (en) * | 2021-12-31 | 2022-03-08 | 湖南华医电磁医学研究院有限公司 | Transcranial magnetic stimulation system and method |
| CN115300798A (en) * | 2022-08-26 | 2022-11-08 | 中国医学科学院生物医学工程研究所 | Transcranial magnetic stimulation pulse signal control method, device, equipment and medium |
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