CN109481845B - Method and related device for transcranial magnetic stimulation acting on different brain areas - Google Patents
Method and related device for transcranial magnetic stimulation acting on different brain areas Download PDFInfo
- Publication number
- CN109481845B CN109481845B CN201811625440.0A CN201811625440A CN109481845B CN 109481845 B CN109481845 B CN 109481845B CN 201811625440 A CN201811625440 A CN 201811625440A CN 109481845 B CN109481845 B CN 109481845B
- Authority
- CN
- China
- Prior art keywords
- magnetic stimulation
- transcranial magnetic
- transcranial
- stimulation
- coil
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N2/00—Magnetotherapy
- A61N2/004—Magnetotherapy specially adapted for a specific therapy
- A61N2/006—Magnetotherapy specially adapted for a specific therapy for magnetic stimulation of nerve tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N2/00—Magnetotherapy
- A61N2/02—Magnetotherapy using magnetic fields produced by coils, including single turn loops or electromagnets
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Radiology & Medical Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Neurology (AREA)
- Magnetic Treatment Devices (AREA)
Abstract
The present application discloses a method and related apparatus for transcranial magnetic stimulation of different brain regions, comprising: the magnetic stimulation system receives a positioning instruction sent by the positioning system, wherein the positioning instruction carries first positioning information of a first brain area and second positioning information of a second brain area; the magnetic stimulation system determining first location information of a first transcranial magnetic stimulation coil that matches the first location information and second location information of a second transcranial magnetic stimulation coil that matches the second location information; the magnetic stimulation system generates a magnetic field through the first transcranial magnetic stimulation coil to act on the first brain region; after a first preset time interval, the magnetic stimulation system generates a magnetic field through the second transcranial magnetic stimulation coil to act on the second brain region. The embodiment of the invention is beneficial to enriching application scenes.
Description
Technical Field
The invention relates to the technical field of computers, in particular to a transcranial magnetic stimulation method acting on different brain areas and a related device.
Background
The study of brain dynamic working mechanism and the improvement of brain function by non-invasive magnetic stimulation is a hot issue in brain science research in recent years. Transcranial Magnetic Stimulation (TMS) is a non-invasive Stimulation of brain tissue through the skull by generating a varying Magnetic field through high-voltage large-capacitance instantaneous discharge, achieving the purpose of temporarily regulating and controlling the excitability of neurons in the cerebral cortex. The weak current field produced by monopulse transcranial magnetic stimulation tms (stms) can cause depolarization of the cortex, which can cause short-term excitatory suppression of the cortex, thereby affecting behavioral output.
As transcranial magnetic stimulation is a non-invasive stimulation means which can change the excitability of neurons in a short time, the method provides a very good opportunity for carrying out cortical cognition and attention-related cause and effect inference research in healthy people.
However, the existing transcranial magnetic stimulation technology only stimulates a single brain region, and the application scene is single.
Disclosure of Invention
The embodiment of the invention provides a transcranial magnetic stimulation method and a related device acting on different brain areas, and the implementation of the embodiment of the invention is beneficial to enriching application scenes.
In a first aspect, embodiments of the present invention provide a method of transcranial magnetic stimulation applied to different brain regions, comprising:
the magnetic stimulation system receives a positioning instruction sent by the positioning system, wherein the positioning instruction carries first positioning information of a first brain area and second positioning information of a second brain area;
the magnetic stimulation system determining first location information of a first transcranial magnetic stimulation coil that matches the first location information and second location information of a second transcranial magnetic stimulation coil that matches the second location information;
the magnetic stimulation system generates a magnetic field through the first transcranial magnetic stimulation coil to act on the first brain region;
after a first preset time interval, the magnetic stimulation system generates a magnetic field through the second transcranial magnetic stimulation coil to act on the second brain region.
A second aspect of an embodiment of the present invention provides a magnetic stimulation system, including:
the positioning system comprises a receiving module, a processing module and a processing module, wherein the receiving module is used for receiving a positioning instruction sent by the positioning system, and the positioning instruction carries first positioning information of a first brain area and second positioning information of a second brain area;
a determination module to determine first location information of a first transcranial magnetic stimulation coil that matches the first location information and second location information of a second transcranial magnetic stimulation coil that matches the second location information;
a first magnetic field generation module for generating a magnetic field by the first transcranial magnetic stimulation coil to act on the first brain region;
and the second magnetic field generation module is used for generating a magnetic field to act on the second brain area through the second transcranial magnetic stimulation coil after a first preset time interval.
It can be seen that, in the above technical solution, first, the magnetic stimulation system receives a positioning instruction carrying first positioning information of a first brain area and second positioning information of a second brain area sent by the positioning system to determine first position information of a first transcranial magnetic stimulation coil matched with the first positioning information and second position information of a second transcranial magnetic stimulation coil matched with the second positioning information, then, the magnetic stimulation system generates a magnetic field to act on the first brain area through the first transcranial magnetic stimulation coil, generates a magnetic field to act on the second brain area through the second transcranial magnetic stimulation coil after a first preset time interval, thereby realizing accurate positioning of different brain areas, so that the transcranial magnetic stimulation coil generates a magnetic field to act on different brain areas, realizing interaction and deduction experimental verification and analysis of different brain areas involved in a cognitive test process, not only enriches the application scenes, but also provides a new research method for the dynamic change research of the information in the brain.
Drawings
In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings used in the description of the embodiments or the prior art will be briefly described below, it is obvious that the drawings in the following description are only some embodiments of the present invention, and for those skilled in the art, other drawings can be obtained according to the drawings without creative efforts.
Wherein:
FIG. 1 is a schematic flow chart of a method for transcranial magnetic stimulation applied to different brain regions according to an embodiment of the present invention;
FIG. 2 is a schematic flow chart of another method for transcranial magnetic stimulation applied to different brain regions according to an embodiment of the present invention;
fig. 3 is a schematic diagram of a magnetic stimulation system according to an embodiment of the present invention.
Detailed Description
The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
The following are detailed below.
The terms "first" and "second" in the description and claims of the present invention and the above-described drawings are used for distinguishing between different objects and not for describing a particular order. Furthermore, the terms "include" and "have," as well as any variations thereof, are intended to cover non-exclusive inclusions. For example, a process, method, system, article, or apparatus that comprises a list of steps or elements is not limited to only those steps or elements listed, but may alternatively include other steps or elements not listed, or inherent to such process, method, article, or apparatus.
Referring first to fig. 1, fig. 1 is a schematic flow chart of a method for transcranial magnetic stimulation applied to different brain regions according to an embodiment of the present invention. As shown in fig. 1, a method for transcranial magnetic stimulation applied to different brain regions according to an embodiment of the present invention may include:
101. and the magnetic stimulation system receives the positioning instruction sent by the positioning system.
The positioning instruction carries first positioning information of the first brain area and second positioning information of the second brain area.
The magnetic stimulation system may comprise, for example, capacitors and inductors.
The capacitor stores a large amount of charges and discharges in a very short time, so that the induction coil of the inductor generates a magnetic field and generates a reverse induced current in the brain. Currents in the cortex can activate large pyramidal neurons, causing microscopic changes in axons, and further causing electrophysiological and functional changes.
The positioning system may include, for example, a neuroimaging navigation positioning system that incorporates imaging techniques such as Magnetic Resonance Imaging (MRI) and functional magnetic resonance imaging (fMRI).
Wherein, the first brain area and the second brain area are a certain part of the brain of the same transcranial magnetic stimulation subject.
Wherein the first brain area is positioned at the upstream of information transmission and processing, and the second brain area is positioned at the downstream of information transmission and processing.
The information transmission and processing related to the embodiment of the invention are the information transmission and processing in the same transcranial magnetic stimulation main body brain.
102. The magnetic stimulation system determines first location information of a first transcranial magnetic stimulation coil that matches the first location information and second location information of a second transcranial magnetic stimulation coil that matches the second location information.
Wherein the first transcranial magnetic stimulation coil and the second transcranial magnetic stimulation coil are induction coils of an inductor in the magnetic stimulation system.
103. A magnetic stimulation system generates a magnetic field through the first transcranial magnetic stimulation coil to act on the first brain region.
104. After a first preset time interval, the magnetic stimulation system generates a magnetic field through the second transcranial magnetic stimulation coil to act on the second brain region.
The first preset time period may include, for example, 5 ms, 10 ms, 15 ms, 20 ms, or other time periods.
Referring to fig. 2, fig. 2 is a flow chart illustrating a method for transcranial magnetic stimulation applied to different brain regions according to an embodiment of the present invention. As shown in fig. 2, a method for transcranial magnetic stimulation applied to different brain regions according to an embodiment of the present invention may include:
201. and the magnetic stimulation system receives the positioning instruction sent by the positioning system.
The positioning instruction carries first positioning information of the first brain area and second positioning information of the second brain area.
The magnetic stimulation system may comprise, for example, capacitors and inductors.
The capacitor stores a large amount of charges and discharges in a very short time, so that the induction coil of the inductor generates a magnetic field and generates a reverse induced current in the brain. Currents in the cortex can activate large pyramidal neurons, causing microscopic changes in axons, and further causing electrophysiological and functional changes.
The positioning system may include, for example, a neuroimaging navigation positioning system that incorporates imaging techniques such as Magnetic Resonance Imaging (MRI) and functional magnetic resonance imaging (fMRI).
Wherein, the first brain area and the second brain area are a certain part of the brain of the same transcranial magnetic stimulation subject.
Wherein the first brain area is positioned at the upstream of information transmission and processing, and the second brain area is positioned at the downstream of information transmission and processing.
The information transmission and processing related to the embodiment of the invention are the information transmission and processing in the same transcranial magnetic stimulation main body brain.
202. The magnetic stimulation system determines first location information of a first transcranial magnetic stimulation coil that matches the first location information and second location information of a second transcranial magnetic stimulation coil that matches the second location information.
Wherein the first transcranial magnetic stimulation coil and the second transcranial magnetic stimulation coil are induction coils of an inductor in the magnetic stimulation system.
203. A magnetic stimulation system generates a magnetic field through the first transcranial magnetic stimulation coil to act on the first brain region.
Optionally, in a first aspect, in one possible implementation of the present invention, the magnetic stimulation system includes a capacitor, and the magnetic stimulation system generates a magnetic field to act on the first brain region through the first transcranial magnetic stimulation coil, and includes:
the magnetic stimulation system discharges the stored charge of the capacitor to form a current;
the magnetic stimulation system generates a magnetic field through the first transcranial magnetic stimulation coil to excitably inhibit the first brain region in a single-pulse stimulation mode while the electrical current is passed through the first transcranial magnetic stimulation coil.
It can be seen that, in the above technical scheme, the magnetic stimulation system releases the electric charge stored in the capacitor to form a current, and then, when the current passes through the first transcranial magnetic stimulation coil, the magnetic stimulation system generates a magnetic field through the first transcranial magnetic stimulation coil to perform excitability suppression on the first brain region by adopting a single-pulse stimulation mode, thereby realizing transcranial magnetic stimulation on the same brain region and causing excitability suppression on the same brain region, thereby realizing influence on upstream information transmission and processing, further influencing behavior output of a transcranial magnetic stimulation main body, and obtaining a cognitive test output result.
Optionally, in a first possible implementation manner of the present invention based on the first aspect, when the current passes through the first transcranial magnetic stimulation coil, the magnetic stimulation system generates a magnetic field through the first transcranial magnetic stimulation coil to perform excitatory suppression on the first brain region in a single-pulse stimulation mode, including:
when the current passes through the first transcranial magnetic stimulation coil, the magnetic stimulation system generates a magnetic field through the first transcranial magnetic stimulation coil, and excitability suppression is performed on the first brain area by adopting the single-pulse stimulation mode every N second preset time intervals, wherein N is a positive integer.
Optionally, the ith preset time period in the N second preset time periods is different from the (i +1) th preset time period in the N second preset time periods, i is greater than 0 and less than or equal to N, and i is a positive integer.
Where i may include, for example, 1, 2, 4, 7, 8, 12, or other values.
The second preset time period may include, for example, 5 ms, 10 ms, 15 ms, 20 ms, or other time periods.
Where N may include, for example, 1, 2, 4, 7, 8, 12, or other values.
It can be seen that, in the above technical scheme, when the current passes through the first transcranial magnetic stimulation coil, the magnetic stimulation system generates a magnetic field through the first transcranial magnetic stimulation coil, and performs excitability suppression on the first brain region by adopting a single-pulse stimulation mode every N second preset time intervals, thereby realizing transcranial magnetic stimulation on the same brain region at different time intervals, causing excitability suppression of the brain region, and verifying the influence of different time intervals repeatedly acting on the same brain region on the output result of the cognitive test.
Optionally, based on the first aspect or the first possible implementation manner of the first aspect, in a second possible implementation manner of the present invention, the method further includes:
while the magnetic field is generated by the first transcranial magnetic stimulation coil, the magnetic stimulation system sends picture presentation instructions to a stimulation presentation system, wherein the picture presentation instructions are used to instruct the stimulation presentation system to display a picture for a cognitive test.
The stimulation presentation system is mainly used for presenting pictures of various cognitive tests and comprises a host, a high-refresh-rate liquid crystal display (AOC G2770PF 144Hz) and psychological stimulation presentation software (such as Matlab and Psychtoolbox toolkits).
It can be seen that, in the above technical solution, when a magnetic field is generated by the first transcranial magnetic stimulation coil, the magnetic stimulation system sends a picture presentation instruction to the stimulation presentation system, so that the stimulation presentation system displays a picture for a cognitive test, thereby displaying the picture for the cognitive test when stimulating a brain region, so that the transcranial magnetic stimulation subject can view the picture and output a cognitive test output result.
Optionally, based on the first aspect or the first or second possible implementation manner of the first aspect, in a third possible implementation manner of the present invention, the method further includes: the magnetic stimulation system sends a transcranial magnetic stimulation ending instruction to the behavior achievement evaluation system, wherein, the transcranial magnetic stimulation ending instruction carries an identity of a transcranial magnetic stimulation main body, the transcranial magnetic stimulation ending instruction is used for indicating the behavior achievement evaluation system to inquire a transcranial magnetic stimulation result matched with the identity from a database, so as to send a transcranial magnetic stimulation result display instruction carrying the transcranial magnetic stimulation result to the stimulation presentation system, the transcranial magnetic stimulation result is obtained by counting transcranial magnetic stimulation parameters by the behavior achievement evaluation system, the transcranial magnetic stimulation parameters comprise a cognition test output result of the transcranial magnetic stimulation main body after N times of transcranial magnetic stimulation, the transcranial magnetic stimulation result display instruction is used for indicating the stimulation presentation system to display the transcranial magnetic stimulation result.
The behavior achievement evaluation system is used for evaluating the behavior achievement.
Optionally, the behavioral performance analysis system is mainly composed of a tool kit developed based on a Matlab platform.
The kit may comprise, for example, an EEG Lab.
The evaluation of the behavior achievement is completed by a data analysis system, and the data analysis system mainly integrates the analysis of different parameters under various experimental paradigms to obtain a final evaluation result. The data analysis system comprises
The database stores key response time RT, accuracy Acc, Name of the tested person, gender Sexual, Age, left and right handedness Hand, experiment time Date and the like.
It can be seen that, in the above technical scheme, the magnetic stimulation system sends a transcranial magnetic stimulation ending instruction carrying the identity of the transcranial magnetic stimulation subject to the behavior achievement evaluation system, so that the behavior achievement evaluation system queries a transcranial magnetic stimulation result matched with the identity from the database, then the behavior achievement evaluation system sends a transcranial magnetic stimulation result display instruction carrying the transcranial magnetic stimulation result to the stimulation presentation system, and then the stimulation presentation system displays the transcranial magnetic stimulation result, thereby realizing visualization of the transcranial magnetic stimulation result.
Optionally, based on the first aspect or the first or second or third possible implementation manner of the first aspect, in a fourth possible implementation manner of the present invention, the transcranial magnetic stimulation result includes:
the key response time, the accuracy and the right and left handedness are good.
204. After a first preset time interval, the magnetic stimulation system generates a magnetic field through the second transcranial magnetic stimulation coil to act on the second brain region.
The first preset time period may include, for example, 5 ms, 10 ms, 15 ms, 20 ms, or other time periods.
Optionally, in a first aspect, in one possible implementation of the present invention, the magnetic stimulation system includes a capacitor, and after a first preset time interval, the magnetic stimulation system generates a magnetic field to act on the second brain region through the second transcranial magnetic stimulation coil, and includes:
the magnetic stimulation system discharges the stored charge of the capacitor to form a current;
when the current passes through the second transcranial magnetic stimulation coil, the magnetic stimulation system generates a magnetic field through the second transcranial magnetic stimulation coil to perform excitatory suppression on the second brain region in a single-pulse stimulation mode.
It can be seen that, in the above technical scheme, the magnetic stimulation system releases the electric charge stored in the capacitor to form a current, and then, when the current passes through the second transcranial magnetic stimulation coil, the magnetic stimulation system generates a magnetic field through the second transcranial magnetic stimulation coil to perform excitability suppression on the second brain region by adopting a single-pulse stimulation mode, thereby realizing transcranial magnetic stimulation on the same brain region and causing excitability suppression on the same brain region, thereby realizing the influence on downstream information transmission and processing, further influencing behavior output of a transcranial magnetic stimulation main body to obtain a cognitive test output result.
Optionally, in a first possible implementation manner of the present invention based on the first aspect, when the current passes through the second transcranial magnetic stimulation coil, the magnetic stimulation system generates a magnetic field through the second transcranial magnetic stimulation coil to perform excitatory suppression on the second brain region using the single-pulse stimulation mode, including:
when the current passes through the second transcranial magnetic stimulation coil, the magnetic stimulation system generates a magnetic field through the second transcranial magnetic stimulation coil, and excitability suppression is performed on the second brain region by adopting the single-pulse stimulation mode every N second preset time periods, wherein N is a positive integer.
Optionally, the ith preset time period in the N second preset time periods is different from the (i +1) th preset time period in the N second preset time periods, i is greater than 0 and less than or equal to N, and i is a positive integer.
Where i may include, for example, 1, 2, 4, 7, 8, 12, or other values.
The second preset time period may include, for example, 5 ms, 10 ms, 15 ms, 20 ms, or other time periods.
Where N may include, for example, 1, 2, 4, 7, 8, 12, or other values.
It can be seen that, in the above technical scheme, when the current passes through the second transcranial magnetic stimulation coil, the magnetic stimulation system generates a magnetic field through the second transcranial magnetic stimulation coil, and performs excitatory suppression on the second brain region by adopting a single-pulse stimulation mode every N second preset time intervals, thereby implementing transcranial magnetic stimulation on the same brain region at different time intervals, causing excitatory suppression of the brain region, and implementing verification of the influence of different time intervals repeatedly acting on the same brain region on the output result of the cognitive test.
Referring to fig. 3, fig. 3 is a schematic diagram of a magnetic stimulation system according to an embodiment of the present invention. As shown in fig. 3, a magnetic stimulation system 300 according to an embodiment of the present invention may include:
the receiving module 301 is configured to receive a positioning instruction sent by a positioning system.
The positioning instruction carries first positioning information of the first brain area and second positioning information of the second brain area.
The magnetic stimulation system may comprise, for example, capacitors and inductors.
The capacitor stores a large amount of charges and discharges in a very short time, so that the induction coil of the inductor generates a magnetic field and generates a reverse induced current in the brain. Currents in the cortex can activate large pyramidal neurons, causing microscopic changes in axons, and further causing electrophysiological and functional changes.
The positioning system may include, for example, a neuroimaging navigation positioning system that incorporates imaging techniques such as Magnetic Resonance Imaging (MRI) and functional magnetic resonance imaging (fMRI).
Wherein, the first brain area and the second brain area are a certain part of the brain of the same transcranial magnetic stimulation subject.
Wherein the first brain area is positioned at the upstream of information transmission and processing, and the second brain area is positioned at the downstream of information transmission and processing.
The information transmission and processing related to the embodiment of the invention are the information transmission and processing in the same transcranial magnetic stimulation main body brain.
A determination module 302 for determining first position information of a first transcranial magnetic stimulation coil matching the first positioning information and second position information of a second transcranial magnetic stimulation coil matching the second positioning information.
A first magnetic field generating module 303 for generating a magnetic field to act on the first brain region by the first transcranial magnetic stimulation coil.
Optionally, in a first aspect, in a possible implementation manner of the present invention, the first magnetic field generating module is specifically configured to:
generating a magnetic field by the first transcranial magnetic stimulation coil when the current passes through the first transcranial magnetic stimulation coil, and performing excitatory suppression on the first brain area by adopting the single-pulse stimulation mode every N second preset time intervals, wherein N is a positive integer.
Optionally, the ith preset time period in the N second preset time periods is different from the (i +1) th preset time period in the N second preset time periods, i is greater than 0 and less than or equal to N, and i is a positive integer.
Where i may include, for example, 1, 2, 4, 7, 8, 12, or other values.
The second preset time period may include, for example, 5 ms, 10 ms, 15 ms, 20 ms, or other time periods.
Where N may include, for example, 1, 2, 4, 7, 8, 12, or other values.
Optionally, based on the first aspect, in a first possible implementation manner of the present invention, the system further includes a sending module, configured to send a picture presenting instruction to the stimulation presentation system when the magnetic field is generated by the first transcranial magnetic stimulation coil, where the picture presenting instruction is configured to instruct the stimulation presentation system to display a picture for a cognitive test.
The stimulation presentation system is mainly used for presenting pictures of various cognitive tests and comprises a host, a high-refresh-rate liquid crystal display (AOC G2770PF 144Hz) and psychological stimulation presentation software (such as Matlab and Psychtoolbox toolkits).
Optionally, based on the first aspect or the first possible implementation manner of the first aspect, in a second possible implementation manner of the present invention, the sending module is further configured to send a transcranial magnetic stimulation ending instruction to the behavioral achievement assessment system, where the transcranial magnetic stimulation ending instruction carries an identity of a transcranial magnetic stimulation subject, the transcranial magnetic stimulation ending instruction is used to instruct the behavioral achievement assessment system to query a transcranial magnetic stimulation result matched with the identity from a database, so as to send a transcranial magnetic stimulation result display instruction carrying the transcranial magnetic stimulation result to the stimulation presentation system, the transcranial magnetic stimulation result is obtained by the behavioral achievement assessment system by counting transcranial magnetic stimulation parameters, and the transcranial magnetic stimulation parameters include a result output from a cognitive test of the transcranial magnetic stimulation subject after N times of transcranial magnetic stimulation, the transcranial magnetic stimulation result display instruction is used for indicating the stimulation presentation system to display the transcranial magnetic stimulation result.
The behavior achievement evaluation system is used for evaluating the behavior achievement.
Optionally, the behavioral performance analysis system is mainly composed of a tool kit developed based on a Matlab platform.
The kit may comprise, for example, an EEG Lab.
The evaluation of the behavior achievement is completed by a data analysis system, and the data analysis system mainly integrates the analysis of different parameters under various experimental paradigms to obtain a final evaluation result. The data analysis system comprises
The database stores key response time RT, accuracy Acc, Name of the tested person, gender Sexual, Age, left and right handedness Hand, experiment time Date and the like.
A second magnetic field generating module 304, configured to generate a magnetic field to act on the second brain region through the second transcranial magnetic stimulation coil after a first preset time interval.
The first preset time period may include, for example, 5 ms, 10 ms, 15 ms, 20 ms, or other time periods.
It should be noted that, for simplicity of description, the above-mentioned method embodiments are described as a series of acts or combination of acts, but those skilled in the art will recognize that the present invention is not limited by the order of acts, as some steps may occur in other orders or concurrently in accordance with the invention. Further, those skilled in the art should also appreciate that the embodiments described in the specification are preferred embodiments and that the acts and modules referred to are not necessarily required by the invention.
In the foregoing embodiments, the descriptions of the respective embodiments have respective emphasis, and for parts that are not described in detail in a certain embodiment, reference may be made to related descriptions of other embodiments.
In the embodiments provided in the present application, it should be understood that the disclosed apparatus may be implemented in other manners. For example, the above-described embodiments of the apparatus are merely illustrative, and for example, the division of the units is only one type of division of logical functions, and there may be other divisions when actually implementing, for example, a plurality of units or components may be combined or may be integrated into another system, or some features may be omitted, or not implemented. In addition, the shown or discussed mutual coupling or direct coupling or communication connection may be an indirect coupling or communication connection of devices or units through some interfaces, and may be an electric or other form.
The units described as separate parts may or may not be physically separate, and parts displayed as units may or may not be physical units, may be located in one place, or may be distributed on a plurality of network units. Some or all of the units can be selected according to actual needs to achieve the purpose of the solution of the embodiment.
In addition, functional units in the embodiments of the present invention may be integrated into one processing unit, or each unit may exist alone physically, or two or more units are integrated into one unit. The integrated unit can be realized in a form of hardware, and can also be realized in a form of a software functional unit.
The integrated unit, if implemented in the form of a software functional unit and sold or used as a stand-alone product, may be stored in a computer readable storage medium. Based on such understanding, the technical solution of the present invention may be embodied in the form of a software product, which is stored in a storage medium and includes instructions for causing a computer device (which may be a personal computer, a server, or a network device) to execute all or part of the steps of the method according to the embodiments of the present invention. And the aforementioned storage medium includes: a U-disk, a Read-Only Memory (ROM), a Random Access Memory (RAM), a removable hard disk, a magnetic or optical disk, and other various media capable of storing program codes.
The above-mentioned embodiments are only used for illustrating the technical solutions of the present invention, and not for limiting the same; although the present invention has been described in detail with reference to the foregoing embodiments, it will be understood by those of ordinary skill in the art that: the technical solutions described in the foregoing embodiments may still be modified, or some technical features may be equivalently replaced; and the modifications or the substitutions do not make the essence of the corresponding technical solutions depart from the scope of the technical solutions of the embodiments of the present invention.
Claims (3)
1. A magnetic stimulation system, comprising:
the positioning system comprises a receiving module, a processing module and a processing module, wherein the receiving module is used for receiving a positioning instruction sent by the positioning system, and the positioning instruction carries first positioning information of a first brain area and second positioning information of a second brain area;
a determination module to determine first location information of a first transcranial magnetic stimulation coil that matches the first location information and second location information of a second transcranial magnetic stimulation coil that matches the second location information;
a first magnetic field generation module for generating a magnetic field by the first transcranial magnetic stimulation coil to act on the first brain region;
a second magnetic field generating module, configured to generate a magnetic field via the second transcranial magnetic stimulation coil to act on the second brain region after a first preset time interval;
wherein the first brain region is upstream of information transfer and processing, and the second brain region is downstream of information transfer and processing;
the first magnetic field generation module is specifically configured to:
when current passes through the first transcranial magnetic stimulation coil, a magnetic field is generated through the first transcranial magnetic stimulation coil, and excitability suppression is carried out on the first brain area by adopting a single-pulse stimulation mode every N second preset time intervals, wherein N is a positive integer.
2. The system according to claim 1, further comprising a sending module for sending picture presentation instructions to a stimulus presentation system when the magnetic field is generated by the first transcranial magnetic stimulation coil, wherein the picture presentation instructions are for instructing the stimulus presentation system to display a picture for a cognitive test.
3. The system of claim 2, wherein the transmitting module is further configured to transmit a transcranial magnetic stimulation end instruction to an behavioral performance assessment system, wherein the transcranial magnetic stimulation ending instruction carries an identity of a transcranial magnetic stimulation subject, the transcranial magnetic stimulation ending instruction is used for instructing the behavior achievement evaluation system to query a transcranial magnetic stimulation result matched with the identity from a database, so as to send a transcranial magnetic stimulation result display instruction carrying the transcranial magnetic stimulation result to the stimulation presentation system, the transcranial magnetic stimulation result is obtained by counting transcranial magnetic stimulation parameters by the behavior achievement evaluation system, the transcranial magnetic stimulation parameters comprise a cognition test output result of the transcranial magnetic stimulation main body after N times of transcranial magnetic stimulation, the transcranial magnetic stimulation result display instruction is used for indicating the stimulation presentation system to display the transcranial magnetic stimulation result.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811625440.0A CN109481845B (en) | 2018-12-28 | 2018-12-28 | Method and related device for transcranial magnetic stimulation acting on different brain areas |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811625440.0A CN109481845B (en) | 2018-12-28 | 2018-12-28 | Method and related device for transcranial magnetic stimulation acting on different brain areas |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN109481845A CN109481845A (en) | 2019-03-19 |
| CN109481845B true CN109481845B (en) | 2022-04-01 |
Family
ID=65713006
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201811625440.0A Active CN109481845B (en) | 2018-12-28 | 2018-12-28 | Method and related device for transcranial magnetic stimulation acting on different brain areas |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN109481845B (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110721401A (en) * | 2019-11-28 | 2020-01-24 | 中国科学院深圳先进技术研究院 | Neural regulation and control system and wearable neural regulation and control device |
| CN116173415A (en) * | 2022-11-18 | 2023-05-30 | 深圳先进技术研究院 | Transcranial magnetic stimulation system, device and medium for relieving anxiety |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2733301A1 (en) * | 2001-05-04 | 2002-11-14 | Board Of Regents, The University Of Texas System | Apparatus and methods for delivery of transcranial magnetic stimulation |
| CN107577343A (en) * | 2017-08-25 | 2018-01-12 | 北京航空航天大学 | It is a kind of based on the notice of haptic device and electroencephalogramsignal signal analyzing training and evaluating apparatus |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2003218433A1 (en) * | 2002-03-25 | 2003-10-13 | Musc Foundation For Research Development | Methods and systems for using transcranial magnetic stimulation to enhance cognitive performance |
| EP2183025B1 (en) * | 2007-08-20 | 2017-07-05 | Cervel Neurotech, Inc. | Firing patterns for deep brain transcranial magnetic stimulation |
| US8974365B2 (en) * | 2012-11-25 | 2015-03-10 | Steven Richard Devore Best | Treatment of thalamocortical dysrhythmia |
| US10485972B2 (en) * | 2015-02-27 | 2019-11-26 | Thync Global, Inc. | Apparatuses and methods for neuromodulation |
| CN106075731A (en) * | 2016-03-02 | 2016-11-09 | 深圳英智科技有限公司 | Based on the dyskinetic method of transcranial magnetic stimulation treatment post-stroke |
| CN105771092A (en) * | 2016-04-01 | 2016-07-20 | 深圳市前海安测信息技术有限公司 | System and method for improving sleep based on electromagnetic field |
| CN106345062B (en) * | 2016-09-20 | 2018-01-16 | 华东师范大学 | A kind of cerebral magnetic stimulation coil localization method based on magnetic resonance imaging |
| CN108042917B (en) * | 2017-12-13 | 2022-02-15 | 深圳先进技术研究院 | Method and device for enhancing multi-object tracking capability |
-
2018
- 2018-12-28 CN CN201811625440.0A patent/CN109481845B/en active Active
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2733301A1 (en) * | 2001-05-04 | 2002-11-14 | Board Of Regents, The University Of Texas System | Apparatus and methods for delivery of transcranial magnetic stimulation |
| CN107577343A (en) * | 2017-08-25 | 2018-01-12 | 北京航空航天大学 | It is a kind of based on the notice of haptic device and electroencephalogramsignal signal analyzing training and evaluating apparatus |
Also Published As
| Publication number | Publication date |
|---|---|
| CN109481845A (en) | 2019-03-19 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| Krieg et al. | Protocol for motor and language mapping by navigated TMS in patients and healthy volunteers; workshop report | |
| Ghaziri et al. | Neurofeedback training induces changes in white and gray matter | |
| Chib et al. | Noninvasive remote activation of the ventral midbrain by transcranial direct current stimulation of prefrontal cortex | |
| Rao et al. | Relationship between finger movement rate and functional magnetic resonance signal change in human primary motor cortex | |
| CN109481845B (en) | Method and related device for transcranial magnetic stimulation acting on different brain areas | |
| Ances et al. | Coupling of neural activation to blood flow in the somatosensory cortex of rats is time-intensity separable, but not linear | |
| Bae et al. | An estimate of placebo effect of repetitive transcranial magnetic stimulation in epilepsy | |
| Tipples et al. | Facial emotion modulates the neural mechanisms responsible for short interval time perception | |
| EP2240077A1 (en) | System and method of cosmetic analysis and treatment diagnosis | |
| CN105007812A (en) | Brain wave signal processing device, brain wave signal processing method, program, and recording medium | |
| Esmaeilpour et al. | Notes on human trials of transcranial direct current stimulation between 1960 and 1998 | |
| Brügger et al. | Tracing toothache intensity in the brain | |
| Zandi Mehran et al. | Improvement of neurofeedback therapy for improved attention through facilitation of brain activity using local sinusoidal extremely low frequency magnetic field exposure | |
| Hong et al. | Effects of low-frequency repetitive transcranial magnetic stimulation on language recovery in poststroke survivors with aphasia: an updated meta-analysis | |
| Ziaei et al. | Functional brain networks involved in gaze and emotional processing | |
| CN108042917A (en) | The Enhancement Method and device of more object tracking abilities | |
| Marín-Morales et al. | Emotional regulation in male batterers when faced with pictures of intimate partner violence. Do they have a problem with suppressing or experiencing emotions? | |
| Belsher et al. | Advances in repetitive transcranial magnetic stimulation for posttraumatic stress disorder: a systematic review | |
| Chiou et al. | The anterior-ventrolateral temporal lobe contributes to boosting visual working memory capacity for items carrying semantic information | |
| Reeder et al. | Preparatory activity in posterior temporal cortex causally contributes to object detection in scenes | |
| Alawi et al. | Modelling the differential effects of age on transcranial magnetic stimulation induced electric fields | |
| Gallasch et al. | Decrease of motor cortex excitability following exposure to a 20 Hz magnetic field as generated by a rotating permanent magnet | |
| Esposito et al. | An integrated TMS-EEG and MRI approach to explore the interregional connectivity of the default mode network | |
| Petsas et al. | Impaired functional connectivity unmasked by simple repetitive motor task in early relapsing-remitting multiple sclerosis | |
| Kasten et al. | Integrating electric field modelling and neuroimaging to explain inter-individual variability of tACS effects |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant |