CN110721401A - Neural regulation and control system and wearable neural regulation and control device - Google Patents
Neural regulation and control system and wearable neural regulation and control device Download PDFInfo
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Abstract
The application discloses a nerve regulation and control system, which comprises a first acquisition module, a first stimulation module, a first control module and a second stimulation module; the first acquisition module, the first stimulation module and the second stimulation module are electrically connected with the first control module; the first control module receives the acquisition instruction and then sends the acquisition instruction to the first acquisition module; the first acquisition module acquires a first electroencephalogram signal after receiving an acquisition instruction; after the first electroencephalogram signal is diagnosed to be abnormal, the first control module receives a first instruction and then sends the first instruction to the first stimulation module, and the first stimulation module releases first electrical stimulation to the first brain area after receiving the first instruction; the first control module receives the second instruction and then sends the second instruction to the second stimulation module, and the second stimulation module releases second electrical stimulation to the second brain area after receiving the second instruction. The side effect of this application is minimum, and treatment is obvious, sets up a plurality of stimulation modules, can treat a plurality of brain areas simultaneously, and efficiency is higher.
Description
Technical Field
The application relates to the technical field of circuit devices for medical treatment, in particular to a nerve regulation and control system and a wearable nerve regulation and control device.
Background
The brain is an organ composed of billions of neurons, the neurons form an interwoven neural network, information is transmitted and integrated among the neural networks through membrane potential distribution of the neurons, and therefore, the abnormality of the neural circuit can be considered as disorder of electrical activity of the brain neural network. In order to regulate and control the neural circuits with disordered electrical activity, scientists developed a neural regulation technology, i.e. a invasive or non-invasive means is used to regulate and control the electrical activity of the brain, thereby achieving the purpose of regulating the brain state.
Currently, technologies that can be used for neural circuit regulation include natural stimulation, drug intervention, electrical, magnetic, force stimulation, etc., all of which essentially alter the electrical activity of the neural network. Among these, natural stimulation is most acceptable to patients with few side effects, but with little effect; drug intervention is most widely used, but its way of affecting the neural circuits is indirect and with large side effects. The electric, magnetic and force stimulation effects are direct, and especially the pain of a patient can be relieved through external non-invasive stimulation intervention. At present, noninvasive transcranial Electrical Stimulation (tES) is widely applied to the field of neural regulation due to its non-invasiveness and convenience, becomes one of the main means for cognitive neuroscience, brain science research and mental disease treatment, and can realize more accurate and efficient regulation by combining neuroimaging technologies, such as magnetic resonance imaging, electroencephalogram, magnetoencephalography and the like.
However, when electrical, magnetic and force stimulation is actually applied, the current therapeutic system has insignificant curative effect and low efficiency, so that a therapeutic system with significant curative effect and high efficiency is urgently needed.
Disclosure of Invention
An object of the application is to provide a neural regulation and control system to solve above-mentioned problem, this application utilizes two stimulation modules directly to scalp release electro photoluminescence, and the side effect is minimum, but treatment is comparatively obvious to set up a plurality of stimulation modules, can treat a plurality of brain areas simultaneously, efficiency is than higher.
The first aspect of the application provides a nerve regulation and control system, which comprises a first acquisition module, a first stimulation module and a second stimulation module, wherein the first acquisition module, the first stimulation module and the second stimulation module are electrically connected with a first control module; the first control module receives an acquisition instruction and sends the acquisition instruction to the first acquisition module; after the first acquisition module receives the acquisition instruction, the first acquisition module acquires a first electroencephalogram signal; the first control module receives a first instruction and a second instruction under the condition that the first brain electrical signal is diagnosed to be abnormal; the first control module sends the first instruction to the first stimulation module, and the first stimulation module releases first electrical stimulation to a first brain area after receiving the first instruction; and the first control module sends the second instruction to the second stimulation module, and the second stimulation module releases second electrical stimulation to a second brain area after receiving the second instruction.
The neuromodulation system as defined above, further comprising a second control module and a digital isolation unit, the second control module being connected between the first control module and the second stimulation module; the digital isolation unit is connected between the first control module and the second control module;
the first control module sends the second instruction to the digital isolation unit; after receiving the second instruction, the digital isolation unit performs current interference isolation processing on the second instruction, and sends the second instruction after the isolation processing to the second control module; and after receiving the second instruction after the isolation processing, the second control module sends the second instruction after the isolation processing to the second stimulation module.
The nerve regulation and control system as described above, further comprising a wireless module, wherein the wireless module is electrically connected to the first control module; the wireless module is used for transmitting the first instruction and the second instruction to the first control module after receiving the first instruction and the second instruction.
The nerve regulation and control system as described above, further comprising a main power supply unit; the main power supply unit is used for supplying power to the first acquisition module, the first stimulation module and the first control module.
The nerve regulation and control system further comprises an auxiliary power supply unit and a power supply isolation unit; the auxiliary power supply unit is electrically connected with the second control module; the power isolation unit is connected between the main power supply unit and the auxiliary power supply unit;
the main power supply unit is used for providing an electric energy source for the auxiliary power supply unit, and the auxiliary power supply unit is used for providing an electric energy source for the second control module and the second stimulation module; the main power supply unit transmits an electric energy source to the power supply isolation unit; after the power isolation unit receives the electric energy source, current interference isolation processing is carried out on the electric energy source, and the electric energy source after isolation processing is transmitted to the auxiliary power supply unit; after receiving the isolated electric energy source, the auxiliary power supply unit transmits the isolated electric energy source to the second control module; and after receiving the isolated electric energy source, the second control module transmits the isolated electric energy source to the second stimulation module.
The neuromodulation system as defined above, further comprising a third stimulation module electrically connected to the first control module; the first control module receives a third instruction in the case that the first brain electrical signal is diagnosed as abnormal; and the first control module sends the third instruction to the third stimulation module, and the third stimulation module releases third electrical stimulation to a third brain area after receiving the third instruction.
The nerve regulation and control system further comprises a second acquisition module, wherein the second acquisition module acquires a second electroencephalogram signal; the first control module receives the first instruction and the second instruction under the condition that the first brain electrical signal and the second brain electrical signal are diagnosed to be abnormal; the first control module sends the first instruction to the first stimulation module, and the first stimulation module releases first electrical stimulation to a first brain area after receiving the first instruction; the first control module sends the second instruction to the second stimulation module, and the second stimulation module releases second electrical stimulation to a second brain area after receiving the second instruction; or, the first control module receives the first instruction when the first brain electrical signal is diagnosed as abnormal; the first control module receives the second instruction when the second brain electrical signal is diagnosed to be abnormal; the first control module sends the first instruction to the first stimulation module, and the first stimulation module releases first electrical stimulation to a first brain area after receiving the first instruction; and the first control module sends the second instruction to the second stimulation module, and the second stimulation module releases second electrical stimulation to a second brain area after receiving the second instruction.
The neuromodulation system as above, wherein the first electrical stimulation and the second electrical stimulation are any one of direct current stimulation, sine wave stimulation, square wave stimulation, or random noise stimulation; the maximum amplitude of the first electrical stimulation and the second electrical stimulation is 1.6 mA; the frequency of the sine wave stimulation and the square wave stimulation is 0-1000 Hz, and the adjusting precision is 1 Hz.
The neuromodulation system as defined above, wherein the first acquisition module comprises an electroencephalogram acquisition electrode and a data acquisition unit; the data acquisition unit is electrically connected with the first control module, and the electroencephalogram acquisition electrode is electrically connected with the data acquisition unit; the electroencephalogram acquisition electrode is used for acquiring a first electroencephalogram signal, acquiring the first electroencephalogram signal and sending the first electroencephalogram signal to the data acquisition unit; and the data acquisition unit converts the first electroencephalogram signal into a digital signal and sends the digital signal to the first control module after receiving the first electroencephalogram signal.
The neuromodulation system as defined above, wherein the brain electrical acquisition electrode comprises a brain electrical electrode, a reference electrode, and a ground electrode.
The nerve regulation and control system further comprises a terminal, wherein an application program APP is installed in the terminal; the APP is in wireless communication with the first control module; after the terminal receives the first electroencephalogram signal, displaying the first electroencephalogram signal on the APP; and the terminal sends the first instruction and the second instruction to the first control module.
A second aspect of the present application provides a wearable neuromodulation device comprising a wearable mount and a neuromodulation system according to any of the first aspects of the present application; the nerve modulation system is arranged on the wearable support.
The wearable neuromodulation device as in the above, wherein the wearable scaffold comprises an annular head band, a connection band, and an extension band; both ends of the connecting belt are fixedly connected with one side of the annular head strap, and the extending belt is fixedly connected with the other side of the annular head strap; the first acquisition module comprises an electroencephalogram acquisition electrode and a data acquisition unit which are electrically connected, and the first stimulation module and the second stimulation module respectively comprise a stimulation circuit and a stimulation electrode which are electrically connected; the data acquisition unit, the stimulation circuit and the first control module are integrated on the inner side of the annular head band; the electroencephalogram acquisition electrode is arranged on the inner side of the annular head cuff or the inner side of the extension band; the stimulation electrode is arranged on the inner side of the annular head band or the inner side of the connecting band.
The nerve regulation and control system comprises a first acquisition module, a first stimulation module, a second stimulation module and a first control module, wherein the first acquisition module, the first stimulation module and the second stimulation module are electrically connected with the first control module; the first control module receives the acquisition instruction and sends the acquisition instruction to the first acquisition module; after the first acquisition module receives the acquisition instruction, the first acquisition module acquires a first electroencephalogram signal; the first control module receives a first instruction and a second instruction under the condition that the first brain electrical signal is diagnosed to be abnormal; the first control module sends the first instruction to the first stimulation module, and the first stimulation module releases first electrical stimulation to the first brain area after receiving the first instruction; and the first control module sends the second instruction to the second stimulation module, and the second stimulation module releases second electrical stimulation to the second brain area after receiving the second instruction. This application utilizes two stimulation modules directly to scalp release electro photoluminescence, and the side effect is minimum, but treatment is comparatively obvious to set up a plurality of stimulation modules, can treat a plurality of brain areas simultaneously, efficiency is than higher.
Drawings
In order to more clearly illustrate the technical solution of the present invention, the drawings needed to be used in the embodiments will be briefly described below, and it is obvious that the drawings in the following description are only some embodiments of the present invention, and other drawings can be obtained by those skilled in the art without creative efforts.
FIG. 1 is a block diagram of a first neuromodulation system according to a first embodiment of the present invention;
FIG. 2 is a block diagram of a second neuromodulation system according to a first embodiment of the present invention;
FIG. 3 is a block diagram of a third neuromodulation system according to the first embodiment of the present invention;
FIG. 4 is a block diagram of a fourth neuromodulation system according to the first embodiment of the present invention;
FIG. 5 is a circuit diagram of a data acquisition unit of a neuromodulation system according to an embodiment of the present invention;
FIG. 6 is a circuit diagram of a first control module of the neuromodulation system provided by embodiments of the present invention;
FIG. 7 is a circuit diagram of a digital isolation unit of a neuromodulation system provided by an embodiment of the present invention;
FIG. 8 is a circuit diagram of a power isolation unit of the neuromodulation system provided by embodiments of the present invention;
FIG. 9 is a block diagram of a neuromodulation system according to a second embodiment of the present invention;
FIG. 10 is a block diagram of a neuromodulation system according to a third embodiment of the present invention;
fig. 11 is a schematic structural diagram of a fourth embodiment of the present invention.
Description of reference numerals:
100-a first acquisition module, 110-a data acquisition unit, 120-an electroencephalogram acquisition electrode, 100 a-a second acquisition module, 200-a first stimulation module, 300-a first control module, 400-a second stimulation module, 410-a stimulation circuit, 420-a stimulation electrode, 400 a-a third stimulation module, 500-a second control module, 500 a-a third control module, 600-an isolation module, 610-a digital isolation unit, 620-a power isolation unit, 700-a wireless module, 800-a power supply module, 810-a main power supply unit, 820-an auxiliary power supply unit, 900-a wearable nerve regulation and control device, 910-a ring-shaped head band, 920-a connecting band, 930-an extension band and 940-a circuit board.
Detailed Description
The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
First embodiment
As shown in fig. 1, a first embodiment of the present invention provides a neuromodulation system, which includes a first acquisition module 100, a first stimulation module 200, a first control module 300, and a second stimulation module 400; the first collection module 100, the first stimulation module 200, and the second stimulation module 400 are all electrically connected to the first control module 300.
The first control module 300 receives the acquisition instruction, transmits the acquisition instruction to the first acquisition module 100, and after the first acquisition module 100 receives the acquisition instruction, the first acquisition module 100 acquires a first electroencephalogram signal; in the case where the first brain electrical signal is diagnosed as abnormal, the first control module 300 receives a first instruction and a second instruction; the first control module 300 sends a first instruction to the first stimulation module 200, and the first stimulation module 200 releases first electrical stimulation to the first brain area after receiving the first instruction; the first control module 300 sends the second instruction to the second stimulation module 400, and the second stimulation module 400 releases the second electrical stimulation to the second brain area after receiving the second instruction.
The first acquisition module 100 is made of a TGAT-generation electroencephalogram acquisition chip, and a specific circuit diagram is shown in fig. 5; the first control module 300 is made of an STM8 chip, and a specific circuit diagram is shown in FIG. 6.
In the neural regulation and control system in the first embodiment of the present invention, when in use, the first collecting module 100 collects the first electroencephalogram signal first, and a person with professional knowledge such as a doctor judges the electrical activity of the brain neural network of the patient according to the first electroencephalogram signal, and if the doctor confirms that the electrical activity of the brain neural network of the patient is disordered, that is, judges that the first electroencephalogram signal is abnormal, at this time, stimulation treatment needs to be performed on the patient. Specifically, the treatment regimen is to deliver a first electrical stimulus to a first brain region using the first stimulation module 200 and a second electrical stimulus to a second brain region using the second stimulation module 400. As can be seen from the above, the neuromodulation system provided by the first embodiment of the present invention can directly release electrical stimulation to the scalp, and has very few side effects and a relatively significant therapeutic effect. And two stimulation modules are arranged, so that two brain areas can be treated simultaneously, and the treatment efficiency is higher.
It will be appreciated that the first brain region and the second brain region correspond to different regions of the brain scalp, respectively, the first brain region may be, for example, the hindbrain region, and the second brain region may be, for example, the parietal region; alternatively, the first brain region may be a forehead region, the second brain region may be a temple region, etc.
The first electrical stimulus and the second electrical stimulus may each be a direct current stimulus, an alternating current stimulus, a sine wave stimulus, a square wave stimulus, a random noise stimulus, or the like. The maximum amplitude of the first electrical stimulation and the second electrical stimulation is 1.6 mA; the frequency of the sine wave stimulation and the square wave stimulation is 0-1000 Hz, and the adjusting precision is 1 Hz. The parameters of the first electrical stimulation and the second electrical stimulation include current intensity, stimulation time, stimulation frequency and the like. The first stimulation module 200 and the second stimulation module 400 are independent from each other, and thus parameters of the first electrical stimulation and the second electrical stimulation which are respectively released may be the same or different.
As will be understood by those skilled in the art, the first instruction and the second instruction received by the first control module 300 are issued by a terminal, which includes a first acquiring unit, a first transmitting unit, and a second transmitting unit; a first acquiring unit acquires a first electroencephalogram signal; the first sending unit sends a first instruction; the second sending unit sends a second instruction. The terminal may be a computer, a mobile phone, or an IPAD, and is not limited herein.
The terminal can be used for any one of the nerve regulation and control systems in any embodiment of the invention to send instructions and acquire the acquired electroencephalogram signals from the nerve regulation and control systems. Specifically, the terminal is installed with a corresponding Application (APP), and the APP can be used in systems such as Windows, android, or IOS.
The detailed working flow is as follows:
a doctor and other professionals operate the APP, so that the APP sends a collection instruction to the first collection module, the first collection module collects a first electroencephalogram signal, and the first collection module starts to collect the first electroencephalogram signal after receiving the collection instruction; the first acquiring unit acquires the first electroencephalogram signal, that is, the first acquiring module transmits the acquired first electroencephalogram signal to the first control module 300, the first control module 300 receives the first electroencephalogram signal, and then the first acquiring unit acquires the first electroencephalogram signal from the first control module 300.
After the terminal acquires the first electroencephalogram signal, displaying detailed information of the first electroencephalogram signal on the APP; at this moment, professionals such as doctors check the first electroencephalogram signal and judge whether the first electroencephalogram signal is abnormal, if the first electroencephalogram signal is judged to be abnormal, the professionals such as doctors can operate the APP, so that a first sending unit on the APP sends a first instruction to the first control module 300, and a second sending unit on the APP sends a second instruction.
In particular, instructions may be sent on the APP to cause the first stimulation module 200 and the second stimulation module 400 to start working simultaneously. In another embodiment, the APP can also send a command to enable the first stimulation module 200 and the second stimulation module 400 to work independently, and a user can select the first stimulation module 200 or the second stimulation module 400 to work according to actual needs. In specific implementation, a first button, a second button and a third button may be arranged on the APP, wherein when the first button is pressed, the first stimulation module 200 may be controlled to work, and when the button is pressed again, the first stimulation module 200 stops working; pressing the second button can control the second stimulation module 400 to work, and pressing the second button again stops the second stimulation module 400; pressing the third button can control the first stimulation module 200 and the second stimulation module 400 to simultaneously operate (at this time, the first command and the second command are the same command), and pressing the third button again can stop the first stimulation module 200 and the second stimulation module 400 simultaneously.
It can be understood that the first collection module 100 starts to collect the first electroencephalogram signal according to the instruction of the terminal, that is, the first collection module 100 is electrically connected to the first control module 300, the terminal sends a collection instruction for the first collection module 100, and the first control module 300 receives the collection instruction for the first collection module 100 to control the first collection module 100 to start collecting the first electroencephalogram signal. The first control module 300 may obtain the acquired first electroencephalogram signal, and send the first electroencephalogram signal to the terminal for displaying. Also, a fourth button may be provided on the APP, and when the fourth button is pressed, the first collection module 100 starts to operate, and when the fourth button is pressed again, the first collection module 100 stops operating.
Referring to fig. 4, a stimulation module for generating direct current stimulation is described in detail below, which can be applied to the first stimulation module 200 and the second stimulation module 400, wherein each of the first stimulation module 200 and the second stimulation module 400 includes a stimulation electrode 420 and a stimulation circuit 410, and the stimulation electrode 420 is electrically connected to the stimulation circuit 410; the stimulation circuit 410 of the first stimulation module 200 is electrically connected to the first control module 300, the stimulation circuit 410 of the second stimulation module 400 is electrically connected to the second control module 500, the stimulation circuit 410 is used for outputting a constant current to the stimulation electrode 420, and the stimulation electrode 420 is used for releasing a direct current stimulation. The stimulation circuit 410 includes a voltage boost circuit and a constant current source circuit, the voltage boost circuit is mainly used for converting a 3.3V power source into a 12V power source required by the constant current source circuit, the constant current source circuit can output a constant current, and the constant current is transmitted to the stimulation electrode 420, so that the stimulation electrode 420 releases a first electrical stimulation to the first brain region or a second electrical stimulation to the second brain region. Of course, other implementations are possible to those skilled in the art.
Referring to fig. 4, a specific embodiment of the first acquisition module 100 is described in detail below, where the first acquisition module 100 includes an electroencephalogram acquisition electrode 120 and a data acquisition unit 110, the data acquisition unit 110 is electrically connected to the first control module 300, the electroencephalogram acquisition electrode 120 is electrically connected to the data acquisition unit 110, the electroencephalogram acquisition electrode 120 is used to acquire a first electroencephalogram signal, and then the electroencephalogram acquisition unit 120 sends the first electroencephalogram signal to the data acquisition unit 110; after receiving the first electroencephalogram signal, the data acquisition unit 110 converts the first electroencephalogram signal into a digital signal and sends the digital signal to the first control module 300. The brain electricity collecting electrode 120 can be made of one of materials such as silver, silver chloride, stainless steel or gold, the brain electricity collecting electrode 120 can directly contact with the scalp, conductive adhesive is not needed when the brain electricity collecting electrode is used, and the collected signal is an electric signal with 10uV magnitude. The signals collected by the electroencephalogram collecting electrode 120 are analog electric signals, and are finally output as digital signals after being amplified, analog filtered and A/D converted by the digital collecting unit, and the digital signals can be finally transmitted to a terminal so as to be checked and judged by professionals such as doctors. The data acquisition unit 110 may be implemented by a TGAG generation electroencephalogram acquisition chip, please refer to fig. 5 specifically.
The following exemplifies a specific embodiment in which the number of the electroencephalogram acquisition electrodes 120 in the first acquisition module 100 is three, and the electroencephalogram stimulation electrodes 120 include three types of electroencephalogram electrodes, reference electrodes, and ground electrodes, and the three electroencephalogram stimulation electrodes 120 are the electroencephalogram electrodes, the reference electrodes, and the ground electrodes, respectively. As can be seen from the above, the neuromodulation system provided by the first embodiment of the present invention can directly release electrical stimulation to the scalp, and has very few side effects and a relatively significant therapeutic effect. And two stimulation modules are arranged, so that two brain areas can be treated simultaneously, currents of two channels are not interfered with each other, and the treatment efficiency is higher.
Referring to fig. 2, the neuromodulation system in the first embodiment may further include a second control module 500 and a digital isolation unit 610, wherein the second control module 500 is connected between the first control module 300 and the second stimulation module 400, and the digital isolation unit 610 is connected between the first control module 300 and the second control module 500; the first control module 300 sends a second instruction to the digital isolation unit 610; after receiving the second instruction, the digital isolation unit 610 performs current interference isolation processing on the second instruction, and sends the second instruction after the isolation processing to the second control module 500; after receiving the second instruction after the isolation processing, the second control module 500 sends the second instruction after the isolation processing to the second stimulation module 400; when the second stimulation module 400 receives the second command, it starts to release the second electrical stimulation to the second brain region.
As can be seen from the above, the digital isolation unit 610 isolates the current interference between the first stimulation module 200 and the second stimulation module 400. Of course, the digital isolation unit 610 simultaneously ensures that the first control module 300 and the second control module 500 normally communicate, and specifically, the digital isolation unit 610 is provided with an IC interface, which can ensure that the first control module 300 and the second control module 500 normally communicate. An implementation circuit diagram of the digital isolation unit 610 is shown in fig. 7.
The second control module 500 is arranged to control the second stimulation module 400, and the digital isolation unit 610 is connected between the first control module 300 and the second control module 500, so that the current interference between the first stimulation module 200 and the second stimulation module 400 can be reduced, the two stimulation modules can respectively better release electrical stimulation, and the treatment effect and the safety are ensured.
Referring to fig. 4, the neuromodulation system according to the first embodiment may further include a wireless module 700, the wireless module 700 is electrically connected to the first control module 300, and the wireless module 700 is configured to transmit the received first instruction and the second instruction to the first control module 300 after receiving the first instruction and the second instruction. The wireless module 700 may be a low-power WIFI transmission module, and may specifically adopt a USR-C210WIFI module. That is, the wireless module 700 actually functions to facilitate communication between the first control module 300 and an external device (e.g., a terminal). The wireless module 700 may transmit the acquired first electroencephalogram signal to an external device, or may transmit a signal of the external device to the first control module 300.
Referring to fig. 3, the first embodiment may further include a power supply module 800, where the power supply module 800 includes a main power supply unit 810, and the main power supply unit 810 is configured to supply power to the first collection module 100, the first stimulation module 200, and the first control module 300.
With continued reference to fig. 2, the neuromodulation system according to the first embodiment may further include an auxiliary power unit 820 and a power isolation unit 620, wherein the auxiliary power unit 820 is electrically connected to the main power unit 810, the main power unit 810 is further configured to supply power to the auxiliary power unit 820, and the auxiliary power unit 820 is configured to supply power to the second stimulation module 400 and the second control module 500. Specifically, the main power supply unit 810 transmits the electric energy source to the power isolation unit 620; after receiving the electric energy source, the power isolation unit 620 performs current interference isolation processing on the electric energy source, and transmits the electric energy source after the isolation processing to the auxiliary power supply unit 820; after receiving the isolated electric energy, the auxiliary power supply unit 820 transmits the isolated electric energy to the second control module 500; after receiving the isolated electrical energy, the second control module 500 transmits the isolated electrical energy to the second stimulation module 400.
Similarly to the digital isolation unit 610 disposed between the first control module 300 and the second control module 500, in order to further avoid the current interference between the first stimulation module 200 and the second stimulation module 400, a power isolation unit 620 is disposed, and the power isolation unit 620 is connected between the main power unit 810 and the auxiliary power unit 820 for isolating the current interference between the first stimulation module 200 and the second stimulation module 400. An implementation circuit diagram of the power isolation unit 620 is shown in fig. 8.
Referring to fig. 3, the digital isolation unit 610 and the power isolation unit 620 may constitute an isolation module 600 disposed between the first stimulation module 200 and the second stimulation module 400; the main power supply unit 810 and the auxiliary power supply unit 820 constitute a power supply module 800. To this end, the first stimulation module 200 has the first control module 300 and the main power supply unit 810 separately, and the second stimulation module 400 has the second control module 500 and the auxiliary power supply unit 820 separately, so that current crosstalk between the first stimulation module 200 and the second stimulation module 400 is completely isolated, which can ensure that the first stimulation module 200 and the second stimulation module 400 independently release electrical stimulation at each location, and increase the accuracy and safety of the first electrical stimulation and the second electrical stimulation.
Second embodiment
Referring to fig. 9, in the second embodiment, a third stimulation module 400a is added on the basis of any one of the neuromodulation systems of the first embodiment, and the third stimulation module 400a is electrically connected to the first control module 300; in the case where the first brain electrical signal is diagnosed as abnormal, the first control module 300 receives a third instruction, and then the first control module 300 transmits the first instruction to the third stimulation module 400 a; the third stimulation module 400a, upon a third instruction, releases a third electrical stimulation to a third brain region.
When the brain neural network electrical activity monitoring system is used, the first acquisition module 100 firstly acquires a first brain electrical signal, and a person with professional knowledge such as a doctor judges the condition of the brain neural network electrical activity of a patient according to the first brain electrical signal, and if the doctor confirms that the brain neural network electrical activity of the patient is disordered, the first brain electrical signal is abnormal. At this time, stimulation treatment needs to be performed on the patient, specifically, the treatment scheme is to enable the first stimulation module 200 to release the first electrical stimulation to the first brain area, enable the second stimulation module 400 to release the second electrical stimulation to the second brain area, and enable the third stimulation module 400a to release the third electrical stimulation to the third brain area.
The first brain area, the second brain area and the third brain area respectively correspond to different areas of the brain scalp, for example, the three brain areas respectively correspond to a forehead area, a hindbrain area and a temple area, or respectively correspond to three other areas, it needs to be emphasized that the three brain areas are all different areas on the brain scalp.
The third electrical stimulus may be a direct current stimulus, an alternating current stimulus, a sine wave stimulus, a square wave stimulus, a random noise stimulus, or the like. The parameters of the third electrical stimulation include current intensity, stimulation time, stimulation frequency, and the like. The first stimulation module 200, the second stimulation module 400 and the third stimulation module 400a are all independent from each other, and therefore, the parameters of the first electrical stimulation, the second electrical stimulation and the third electrical stimulation which are respectively released may be the same or different.
In this embodiment, the third stimulation module 400a is added, so that electrical stimulation can be simultaneously performed on three different brain regions, and the treatment effect and efficiency are further enhanced.
Of course, in this embodiment, a third control module 500a may be provided for the third stimulation module 400a, the third control module 500a is connected between the first control module 300 and the third control module 500a, the third instruction received by the first control module 300 is sent to the third control module 500a, and the third control module 500a receives the third instruction and releases the third electrical stimulation to the third brain area.
Similarly, a digital isolation unit 610 may be disposed between the first control module 300 and the third control module 500a, thereby isolating current interference between the first stimulation module 200 and the third stimulation module 400 a. A secondary power unit 820 may also be provided for the third stimulation module 400a, the secondary power unit 820 providing power to the third stimulation module 400a and the third control module 500 a. Likewise, a power isolation unit 620 may be provided between the main power unit 810 and the auxiliary power unit 820 for the third stimulation module 400a to further isolate the current interference between the first stimulation module 200 and the third stimulation module 400 a.
One skilled in the art will appreciate that a fourth stimulation module, a fifth stimulation module, etc. may also be provided in the same manner as the third stimulation module 400a and will not be described in detail herein.
Accordingly, the terminal may further include a third transmitting unit that transmits the third instruction. The third instruction is directed to a neuromodulation system provided with a third stimulation module 400 a. In a specific scheme, as with the first sending unit and the second sending unit, for example, a fifth button may be provided on the APP for controlling sending of the third instruction, and details are not repeated.
Third embodiment
Referring to fig. 10, a third embodiment is to add a second collecting module 110a on the basis of any one of the neural regulation systems of the first embodiment, wherein the second collecting module 110a collects a second electroencephalogram signal; the first control module 300 receives a first instruction and a second instruction in a case where the first brain electrical signal and the second brain electrical signal are diagnosed as abnormal; the first control module 300 sends a first instruction to the first stimulation module 200, and the first stimulation module 200 releases first electrical stimulation to the first brain area after receiving the first instruction; the first control module 300 sends the second instruction to the second stimulation module 400, and the second stimulation module 400 releases the second electrical stimulation to the second brain area after receiving the second instruction. That is, the professional such as the doctor determines the first instruction and the second instruction according to the comprehensive abnormal condition of the first electroencephalogram signal and the second electroencephalogram signal, and then operates the APP, so that the first instruction and the second instruction are issued to the first control module 300.
Alternatively, in the case where the first brain electrical signal is diagnosed as abnormal, the first control module 300 receives a first instruction; in the case where the second brain electrical signal is diagnosed as abnormal, the first control module 300 receives a second instruction; the first control module 300 sends a first instruction to the first stimulation module 200, and the first stimulation module 200 releases first electrical stimulation to the first brain area after receiving the first instruction; the first control module 300 sends the second instruction to the second stimulation module 400, and the second stimulation module 400 releases the second electrical stimulation to the second brain area after receiving the second instruction. That is, a professional such as a doctor determines to release the first electrical stimulation to the first brain area according to the abnormal condition of the first electroencephalogram signal, and determines to release the second electrical stimulation to the second brain area according to the abnormal condition of the second electroencephalogram signal. It will be appreciated that in this embodiment, the first brain electrical signal and the first electrical stimulus are preferably directed to the same brain scalp area, e.g., the first brain electrical signal is collected as a signal of the hindbrain area, and the first electrical stimulus is delivered to the hindbrain area. Likewise, the second electrical brain signal and the second electrical stimulation are preferably directed to the same brain scalp region.
It should be understood that the first acquisition module 100 and the second acquisition module 110a acquire brain electrical signals of different areas on the brain scalp. The doctor may determine the parameters of the first stimulation module 200 and the second stimulation module 400 according to the comprehensive judgment result of the first electroencephalogram signal and the second electroencephalogram signal, and may set the parameters to be different or the same. Of course, the doctor may also determine the parameters of the first stimulation module 200 according to the condition of the first electroencephalogram signal, and determine the parameters of the second stimulation module 400 according to the condition of the second electroencephalogram signal.
Preferably, the first collection module 100 may collect a first brain electrical signal of a first brain area, the second collection module 110a may collect a second brain electrical signal of a second brain area, and then the doctor determines a parameter of a first electrical stimulation applied to the first brain area by the first stimulation module 200 according to the first brain electrical signal and determines a parameter of a second electrical stimulation applied to the second brain area by the second stimulation module 400 according to the second brain electrical signal, thereby realizing targeted release of electrical stimulation and increasing diagnosis and treatment accuracy.
Of course, a third acquisition module and a fourth acquisition module may be further provided, and the description is omitted.
Correspondingly, the terminal can further comprise a second acquisition unit, and the second acquisition unit acquires a second electroencephalogram signal; when a doctor diagnoses that the first electroencephalogram signal and the second electroencephalogram signal are abnormal, a first button (namely a first sending unit) is operated to send a first instruction; the second button (i.e., the second transmitting unit) is operated to transmit the second instruction.
Or when the doctor diagnoses the abnormality of the first brain point signal, operating a first button (namely, a first sending unit) to send a first instruction; when the doctor diagnoses the second signal abnormality, the doctor operates the second button (i.e., the second sending unit) to send a second command. The second obtaining unit is provided with a second collecting module 110a, and the specific scheme of the second obtaining unit is the same as that of the first obtaining unit, for example, a sixth button may be provided on the APP for controlling the obtaining of the second electroencephalogram signal.
Fourth embodiment
Referring to fig. 9, a fifth embodiment of the present invention provides a wearable nerve modulation device 900, including a wearable support and any one of the nerve modulation systems of the first to third embodiments; the nerve modulation system is arranged on the wearable support.
Specifically, the wearable mount includes a loop-shaped head band 910, a connection band 920, and an extension band 930; both ends of the connecting band 920 are fixedly connected with one side of the annular head band 910, and the extending band 930 is fixedly connected with the other side of the annular head band 910; the first acquisition module 100 comprises an electroencephalogram acquisition electrode 120 and a data acquisition unit 110 which are electrically connected, and the first stimulation module 200 and the second stimulation module 400 each comprise a stimulation circuit 410 and a stimulation electrode 420 which are electrically connected; the data acquisition unit 110, the stimulation circuit 410 and the first control module 300 are all integrated inside the circular head band 910; the brain electricity collecting electrode 120 is arranged on the inner side of the annular head band 910 or the inner side of the extension band 930; the stimulation electrode 420 is disposed inside the loop-shaped head band 910 or inside the connection band 920.
The following exemplifies a specific embodiment in which the number of the brain electricity collecting electrodes 120 in the first collecting module 100 is three, wherein two brain electricity collecting electrodes 120 are disposed on the inner side surface of the ring-shaped headgear 910 for collecting the electric signals at the forehead lobe of the user; another brain electrical acquisition electrode 120 is disposed on the extension band 930 for acquiring electrical signals at the mastoid process of the user's left ear. The brain electrical stimulation electrodes 120 include three types of brain electrical electrodes, reference electrodes and ground electrodes, and the three brain electrical stimulation electrodes 120 are the brain electrical electrodes, the reference electrodes and the ground electrodes respectively.
In the following embodiments, the number of the stimulation electrodes 420 of the first stimulation module 200 and the second stimulation module 400 is two, and the two stimulation electrodes 420 of the first stimulation module 200 are respectively disposed at two ends of the inner side of the connecting band 920; both stimulation electrodes 420 of the second stimulation module 400 are arranged inside the ring-shaped head band 910. The stimulating electrode 420 can be made of silver or silver chloride and other materials, and the stimulating electrode 420 can directly contact with the scalp without conductive adhesive when in use.
Specifically, the data acquisition unit 110, the stimulation circuit 410 and the first control module 300 are integrated on a circuit board 940, and the circuit board 940 is installed inside the circular head band 910 and corresponds to the area of the hindbrain of the patient. Of course, for the neuromodulation system including the second control module 500, the third control module 500a, the wireless module 700, the power module, and the isolation module 600, the rest of the components are all integrated on one circuit board 940 except the stimulation electrode 420 in the stimulation module and the electroencephalogram collecting electrode 120 in the collecting module. The structure compactness of the wearable nerve regulation and control device 900 is increased, and the wearable nerve regulation and control device is convenient for a patient to wear.
The above embodiments of the present invention are described in detail, and the principle and the implementation of the present invention are explained by applying specific embodiments, and the above description of the embodiments is only used to help understanding the method of the present invention and the core idea thereof; meanwhile, for a person skilled in the art, according to the idea of the present invention, there may be variations in the specific embodiments and the application scope, and in summary, the content of the present specification should not be construed as a limitation to the present invention.
Claims (13)
1. A nerve regulation and control system is characterized by comprising a first acquisition module, a first stimulation module, a first control module and a second stimulation module;
the first acquisition module, the first stimulation module and the second stimulation module are electrically connected with the first control module;
the first control module receives an acquisition instruction and sends the acquisition instruction to the first acquisition module; the first acquisition module acquires a first electroencephalogram signal after receiving the acquisition instruction;
the first control module receives a first instruction and a second instruction under the condition that the first brain electrical signal is diagnosed to be abnormal;
the first control module sends the first instruction to the first stimulation module, and the first stimulation module releases first electrical stimulation to a first brain area after receiving the first instruction; and the first control module sends the second instruction to the second stimulation module, and the second stimulation module releases second electrical stimulation to a second brain area after receiving the second instruction.
2. The neuromodulation system as in claim 1, further comprising a second control module and a digital isolation unit, the second control module being connected between the first control module and the second stimulation module; the digital isolation unit is connected between the first control module and the second control module;
the first control module sends the second instruction to the digital isolation unit; after receiving the second instruction, the digital isolation unit performs current interference isolation processing on the second instruction, and sends the second instruction after the isolation processing to the second control module; and after receiving the second instruction after the isolation processing, the second control module sends the second instruction after the isolation processing to the second stimulation module.
3. The neuromodulation system as in claim 1 or 2, further comprising a wireless module electrically connected to the first control module; the wireless module is used for transmitting the first instruction and the second instruction to the first control module after receiving the first instruction and the second instruction.
4. The neuromodulation system as in claim 2, further comprising a main power supply unit; the main power supply unit is used for supplying power to the first acquisition module, the first stimulation module and the first control module.
5. The neuromodulation system as in claim 4, further comprising an auxiliary power unit and a power isolation unit; the auxiliary power supply unit is electrically connected with the second control module; the power isolation unit is connected between the main power supply unit and the auxiliary power supply unit;
the main power supply unit is used for providing an electric energy source for the auxiliary power supply unit, and the auxiliary power supply unit is used for providing an electric energy source for the second control module and the second stimulation module;
the main power supply unit transmits an electric energy source to the power supply isolation unit; after the power isolation unit receives the electric energy source, current interference isolation processing is carried out on the electric energy source, and the electric energy source after isolation processing is transmitted to the auxiliary power supply unit; after receiving the isolated electric energy source, the auxiliary power supply unit transmits the isolated electric energy source to the second control module; and after receiving the isolated electric energy source, the second control module transmits the isolated electric energy source to the second stimulation module.
6. The neuromodulation system as in claim 1 or 2, further comprising a third stimulation module, the third stimulation module being electrically connected to the first control module;
the first control module receives a third instruction in the case that the first brain electrical signal is diagnosed as abnormal;
and the first control module sends the third instruction to the third stimulation module, and the third stimulation module releases third electrical stimulation to a third brain area after receiving the third instruction.
7. The neuromodulation system as in claim 1 or 2, further comprising a second acquisition module that acquires a second electrical brain signal;
the first control module receives the first instruction and the second instruction under the condition that the first brain electrical signal and the second brain electrical signal are diagnosed to be abnormal; the first control module sends the first instruction to the first stimulation module, and the first stimulation module releases first electrical stimulation to a first brain area after receiving the first instruction; the first control module sends the second instruction to the second stimulation module, and the second stimulation module releases second electrical stimulation to a second brain area after receiving the second instruction; or,
the first control module receives the first instruction when the first brain electrical signal is diagnosed as abnormal; the first control module receives the second instruction when the second brain electrical signal is diagnosed to be abnormal; the first control module sends the first instruction to the first stimulation module, and the first stimulation module releases first electrical stimulation to a first brain area after receiving the first instruction; and the first control module sends the second instruction to the second stimulation module, and the second stimulation module releases second electrical stimulation to a second brain area after receiving the second instruction.
8. The neuromodulation system as in claim 1 or 2, wherein the first and second electrical stimuli are any of direct current stimulation, sine wave stimulation, square wave stimulation, or random noise stimulation; the maximum amplitude of the first electrical stimulation and the second electrical stimulation is 1.6 mA; the frequency of the sine wave stimulation and the square wave stimulation is 0-1000 Hz, and the adjusting precision is 1 Hz.
9. The neuromodulation system as in claim 1 or 2, wherein the first acquisition module comprises an electroencephalogram acquisition electrode and a data acquisition unit; the data acquisition unit is electrically connected with the first control module, and the electroencephalogram acquisition electrode is electrically connected with the data acquisition unit;
the electroencephalogram acquisition electrode is used for acquiring a first electroencephalogram signal, acquiring the first electroencephalogram signal and sending the first electroencephalogram signal to the data acquisition unit; and the data acquisition unit converts the first electroencephalogram signal into a digital signal and sends the digital signal to the first control module after receiving the first electroencephalogram signal.
10. The neuromodulation system as in claim 9, wherein the brain electrical acquisition electrode comprises a brain electrical electrode, a reference electrode, and a ground electrode.
11. The neuromodulation system as in claim 1 or 2, further comprising a terminal, wherein the terminal has an application APP installed therein; the APP is in wireless communication with the first control module; after the terminal receives the first electroencephalogram signal, displaying the first electroencephalogram signal on the APP;
and the terminal sends the first instruction and the second instruction to the first control module.
12. A wearable neuromodulation device comprising a wearable support and the neuromodulation system of any of claims 1 to 11; the nerve modulation system is arranged on the wearable support.
13. The wearable neuromodulation device of claim 12, wherein the wearable scaffold comprises a loop-shaped head band, a connection band, and an extension band; both ends of the connecting belt are fixedly connected with one side of the annular head strap, and the extending belt is fixedly connected with the other side of the annular head strap;
the first acquisition module comprises an electroencephalogram acquisition electrode and a data acquisition unit which are electrically connected, and the first stimulation module and the second stimulation module respectively comprise a stimulation circuit and a stimulation electrode which are electrically connected;
the data acquisition unit, the stimulation circuit and the first control module are integrated on the inner side of the annular head band; the electroencephalogram acquisition electrode is arranged on the inner side of the annular head cuff or the inner side of the extension band; the stimulation electrode is arranged on the inner side of the annular head band or the inner side of the connecting band.
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| PCT/CN2020/129213 WO2021104098A1 (en) | 2019-11-28 | 2020-11-17 | Nerve regulation system and wearable nerve regulation device |
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| WO2021104098A1 (en) * | 2019-11-28 | 2021-06-03 | 中国科学院深圳先进技术研究院 | Nerve regulation system and wearable nerve regulation device |
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| CN114042251B (en) * | 2021-11-17 | 2022-08-09 | 国家康复辅具研究中心 | Multi-target point photo-magnetic-electric coupling nerve regulation and control device and method |
| CN114870250A (en) * | 2022-04-20 | 2022-08-09 | 浙江帝诺医疗科技有限公司 | Nerve regulation system and nerve regulation stimulator based on same |
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