CN116158838A - Irreversible electroporation pulse generation system - Google Patents
Irreversible electroporation pulse generation system Download PDFInfo
- Publication number
- CN116158838A CN116158838A CN202310268238.1A CN202310268238A CN116158838A CN 116158838 A CN116158838 A CN 116158838A CN 202310268238 A CN202310268238 A CN 202310268238A CN 116158838 A CN116158838 A CN 116158838A
- Authority
- CN
- China
- Prior art keywords
- pulse
- unit
- equal
- voltage
- trigger
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B18/04—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating
- A61B18/12—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating by passing a current through the tissue to be heated, e.g. high-frequency current
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B18/04—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating
- A61B18/12—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating by passing a current through the tissue to be heated, e.g. high-frequency current
- A61B18/14—Probes or electrodes therefor
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B2018/00571—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body for achieving a particular surgical effect
- A61B2018/00577—Ablation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B2018/00571—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body for achieving a particular surgical effect
- A61B2018/00595—Cauterization
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B2018/00636—Sensing and controlling the application of energy
- A61B2018/00696—Controlled or regulated parameters
- A61B2018/00767—Voltage
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B18/04—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating
- A61B18/12—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating by passing a current through the tissue to be heated, e.g. high-frequency current
- A61B18/1206—Generators therefor
- A61B2018/1246—Generators therefor characterised by the output polarity
- A61B2018/126—Generators therefor characterised by the output polarity bipolar
Landscapes
- Health & Medical Sciences (AREA)
- Surgery (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biomedical Technology (AREA)
- Otolaryngology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Plasma & Fusion (AREA)
- Physics & Mathematics (AREA)
- Heart & Thoracic Surgery (AREA)
- Medical Informatics (AREA)
- Molecular Biology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Electrotherapy Devices (AREA)
Abstract
The invention discloses an irreversible electroporation pulse generating system, comprising: the device comprises a power supply selection module, a control module and a pulse generation module; the power supply selection module is used for selecting output voltage according to the control signal sent by the control module; the output voltage at least comprises a first voltage and a second voltage, and the first voltage and the second voltage are different in magnitude; the pulse generation module is used for generating bipolar pulse signals according to the trigger signals sent by the control module and the output voltage of the power supply selection module. The irreversible electroporation pulse generation system provided by the embodiment of the invention can generate high-voltage high-frequency bipolar pulse and low-voltage low-frequency bipolar pulse, wherein the high-voltage high-frequency bipolar pulse can generate electroporation effect on the premise of not generating muscle contraction, and the low-voltage low-frequency bipolar pulse can enhance the electroporation effect on the premise of not generating muscle contraction, so that the tissue ablation effect is enhanced, and the ablation is more thorough.
Description
Technical Field
The embodiment of the invention relates to the technical field of application of high-voltage pulse medical technology, in particular to an irreversible electroporation pulse generation system.
Background
Pulsed electric field irreversible electroporation has been successfully used in tissue ablation and is effective in preserving the functional integrity of surrounding vital tissues (e.g., large blood vessels, nerves, etc.) when ablating undesirable tissues (e.g., malignant tumors).
In the prior art, the single-polarity pulse is adopted to ablate bad tissues, so that the ablation effect is better, but the contraction of peripheral muscle tissues can be caused, so that the electrode needle is shifted, and the treatment effect is affected. The high-frequency irreversible electroporation technology can effectively reduce side effects caused by muscle contraction while ablating bad tissues.
However, the high-frequency irreversible electroporation has narrow pulse width and high equivalent frequency, so that the ablation effect is remarkably low, namely tumor cell residues and incomplete tissue ablation can be caused in the process of removing tumor tissues.
Disclosure of Invention
The invention provides an irreversible electroporation pulse generation system which can generate high-voltage high-frequency bipolar pulses and low-voltage low-frequency bipolar pulses and can enhance tissue ablation effect while reducing muscle contraction.
An embodiment of the present invention provides an irreversible electroporation pulse generating system comprising: the device comprises a power supply selection module, a control module and a pulse generation module; the power supply selection module is electrically connected with the control module and is used for selecting output voltage according to a control signal sent by the control module; the output voltage at least comprises a first voltage and a second voltage, and the first voltage and the second voltage are different in magnitude; the pulse generation module is respectively and electrically connected with the power supply selection module and the control module and is used for generating bipolar pulse signals according to the trigger signals sent by the control module and the output voltage of the power supply selection module.
Optionally, the power supply selection module includes: the power supply comprises a first power supply, a second power supply and a first switch unit, wherein the first power supply is used for outputting a first voltage, and the second power supply is used for outputting a second voltage; the first switch unit is connected between the positive poles of the first power supply and the second power supply, and the negative pole of the first power supply is electrically connected with the negative pole of the second power supply; the control end of the first switch unit is electrically connected with the control module; a pulse generating module is connected between the positive electrode and the negative electrode of the second power supply; the pulse generation module is used for generating a first pulse waveform according to a first trigger signal sent by the control module when the control module controls the first switch unit to be turned on; when the control module controls the first switch unit to be turned off, a second pulse waveform is generated according to a second trigger signal sent by the control module; the voltage range of the first pulse waveform is larger than that of the second pulse waveform, and the pulse equivalent frequency of the first pulse waveform is higher than that of the second pulse waveform.
Optionally, the control end of the first switch unit is electrically connected with the control module through the first trigger unit, and the control module is used for controlling the on state of the first switch unit by outputting a control signal to the first trigger unit.
Optionally, the voltage range of the first pulse waveform is greater than or equal to-6 kV and less than or equal to 6kV, the pulse equivalent frequency range of the first pulse waveform is greater than or equal to 10kHz and less than or equal to 2MHz, and the pulse width range of the first pulse waveform is greater than or equal to 200ns and less than or equal to 2 μs.
Optionally, the control module is configured to control each duration on time of the first switch unit to be greater than or equal to 20 μs and less than or equal to 10ms, so that a pulse output time range of the first pulse waveform is greater than or equal to 20 μs and less than or equal to 10ms.
Optionally, the voltage range of the second pulse waveform is greater than or equal to-0.6 kV and less than or equal to 0.6kV, the pulse equivalent frequency range of the second pulse waveform is greater than or equal to 1Hz and less than or equal to 500Hz, the pulse width range of the second pulse waveform is greater than or equal to 1ms and less than or equal to 500ms, and the pulse output time range of the second pulse waveform is greater than or equal to 40ms and less than or equal to 1s.
Optionally, the control module is further configured to output the off control signal and the on control signal to the first switch unit at a time interval of greater than or equal to 1ms and less than or equal to 10s, and output the second trigger signal and the first trigger signal to the pulse generating module at a time interval of greater than or equal to 1ms and less than or equal to 10s, so that an interval time between the pulse generating module outputting the second pulse waveform and the first pulse waveform is greater than or equal to 1ms and less than or equal to 10s.
Optionally, the power supply selection module further includes an anti-reflection diode, the positive electrode of the anti-reflection diode is electrically connected with the positive electrode of the second power supply, and the negative electrode of the anti-reflection diode is electrically connected with the common end of the first switch unit and the pulse generation module.
Optionally, the pulse generating module includes a trigger circuit and an H-bridge pulse generating circuit formed by the second switch unit, the third switch unit, the fourth switch unit and the fifth switch unit, where the trigger circuit is electrically connected with the control module, the second switch unit, the third switch unit, the fourth switch unit and the fifth switch unit respectively, and the trigger circuit is used to control the conduction time sequences of the second switch unit, the third switch unit, the fourth switch unit and the fifth switch unit according to the trigger signal issued by the control module.
Optionally, the trigger circuit includes a second trigger unit correspondingly connected with the second switch unit, a third trigger unit correspondingly connected with the third switch unit, a fourth trigger unit correspondingly connected with the fourth switch unit, and a fifth trigger unit correspondingly connected with the fifth switch unit; the control module comprises a host computer, a Field programmable gate array (Field-ProgrammableGateArray, FPGA) unit, a signal level enhancement unit and an electric-optical-electric conversion unit, wherein the host computer is used for sending an initial control signal and an initial trigger signal to the FPGA unit, the FPGA unit is used for enhancing the initial control signal through the signal level enhancement unit to obtain a control signal and enhancing the initial trigger signal to obtain a trigger signal, the signal level enhancement unit is used for transmitting the control signal to the power supply selection module through the electric-optical-electric conversion unit and transmitting the trigger signal to the second trigger unit, the third trigger unit, the fourth trigger unit and the fifth trigger unit through the electric-optical-electric conversion unit.
According to the technical scheme, the power supply selection module is used for selecting output voltage according to the control signal sent by the control module, wherein the output voltage at least comprises a first voltage and a second voltage which are different in size; the pulse generation module generates adjustable high-voltage high-frequency bipolar pulse or low-voltage low-frequency bipolar pulse according to the trigger signal sent by the control module and the output voltage of the power supply selection module, wherein the high-voltage high-frequency bipolar pulse can generate electroporation effect on the premise of not generating muscle contraction, and the low-voltage low-frequency pulse bipolar pulse can enhance electroporation effect on the premise of not generating muscle contraction, so that tissue ablation effect is enhanced while muscle contraction is lightened, and tissue ablation is more thorough.
Drawings
FIG. 1 is a schematic diagram of an irreversible electroporation pulse generation system according to an embodiment of the present invention;
FIG. 2 is a schematic diagram of another irreversible electroporation pulse generation system according to an embodiment of the present invention;
FIG. 3 is a schematic diagram of yet another irreversible electroporation pulse generator system according to an embodiment of the present invention;
FIG. 4 is a schematic diagram of a high voltage high frequency bipolar pulse output waveform according to an embodiment of the present invention;
fig. 5 is a schematic diagram of a low-voltage low-frequency bipolar pulse output waveform according to an embodiment of the present invention.
Detailed Description
The invention is described in further detail below with reference to the drawings and examples. It is to be understood that the specific embodiments described herein are merely illustrative of the invention and are not limiting thereof. It should be further noted that, for convenience of description, only some, but not all of the structures related to the present invention are shown in the drawings.
Fig. 1 is a schematic structural diagram of an irreversible electroporation pulse generating system according to an embodiment of the invention, and the embodiment is applicable to a case of generating high-voltage high-frequency bipolar pulses and low-voltage low-frequency bipolar pulses to ablate tissues.
As shown in fig. 1, the irreversible electroporation pulse generating system includes: a power selection module 10, a control module 20, and a pulse generation module 30; the power supply selection module 10 is electrically connected with the control module 20 and is used for selecting output voltage according to a control signal sent by the control module 20; the output voltage at least comprises a first voltage and a second voltage, and the first voltage and the second voltage are different in magnitude; the pulse generating module 30 is electrically connected to the power selecting module 10 and the control module 20, and is configured to generate a bipolar pulse signal according to the trigger signal sent by the control module 20 and the output voltage of the power selecting module 10.
Specifically, the power supply selection module 10 may include a plurality of power supplies with different voltage levels and a selection switch, and output of different output voltages is realized by selecting the power supplies and the selection switch. Optionally, the power selection module 10 selects the output voltage according to the control signal sent by the control module 20, where the output voltage includes at least a first voltage and a second voltage, and the first voltage and the second voltage are different. Alternatively, the value of the first voltage may be greater than the value of the second voltage, and the value of the first voltage may be less than the value of the second voltage.
The control module 20 may include a micro-control unit. Optionally, the control module 20 may include a single-chip microcomputer, and may further include digital signal processing (DigitalSignalProcessing, DSP) or an FPGA. The control module 20 is used for controlling the power selection module 10 to select the output voltage. Illustratively, when the control signal sent by the control module 20 is at a high level, the power selection module 10 selects the output voltage to be the first voltage; when the control signal sent by the control module 20 is at a low level, the power selection module 20 selects the output voltage to be the second voltage. The control module 20 is further configured to output a trigger signal to the pulse generation module 30 while outputting a control signal to the power selection module 10, so as to implement a cooperation between the power selection module 10 and the pulse generation module 30, and further implement a time-sharing output of the high-voltage high-frequency bipolar pulse and the low-voltage low-frequency bipolar pulse. Illustratively, when the control signal sent by the control module 20 is at a high level, the power selection module 10 selects the output voltage to be the first voltage, and the pulse generation module 30 generates a high-voltage high-frequency pulse waveform according to the trigger signal sent by the control module 20. When the control signal sent by the control module 20 is at a low level, the power selection module 20 selects the output voltage to be the second voltage, and the pulse generation module 30 generates a low-voltage low-frequency pulse waveform according to the trigger signal sent by the control module 20. The pulse generating module 30 may be an H-bridge pulse generating circuit, and the trigger signal output by the control module 20 controls the on timing of the switch unit in the H-bridge pulse generating circuit, so as to generate the pulse signal.
It should be noted that, the pulse generating module 30 may be implemented by other circuits that can generate pulse waveforms in the prior art, and the embodiment is not limited herein.
The irreversible electroporation pulse generation system provided by the embodiment of the invention comprises a power supply selection module, a control module and a pulse generation module; the power supply selection module selects output voltage according to the control signal sent by the control module, wherein the output voltage at least comprises a first voltage and a second voltage with different magnitudes; the pulse generation module is used for generating high-voltage high-frequency bipolar pulses or low-voltage low-frequency bipolar pulses with adjustable parameter ranges according to the trigger signals sent by the control module and the output voltage of the power supply selection module, wherein the high-voltage high-frequency bipolar pulses can generate electroporation effect on the premise of not generating muscle contraction, and the low-voltage low-frequency bipolar pulses can enhance the electroporation effect on the premise of not generating muscle contraction, so that the tissue ablation effect is enhanced while the muscle contraction is lightened, and the tissue ablation is more thorough.
FIG. 2 is a schematic diagram of another irreversible electroporation pulse generator system according to an embodiment of the invention. Referring to fig. 2, the power selection module 10 may optionally include: a first power supply V1, a second power supply V2, and a first switching unit S1, the first power supply V1 for outputting a first voltage, the second power supply V2 for outputting a second voltage; the first switch unit S1 is connected between the positive poles of the first power supply V1 and the second power supply V2, and the negative pole of the first power supply V1 is electrically connected with the negative pole of the second power supply V2; the control end of the first switch unit S1 is electrically connected with the control module 20; a pulse generation module 30 is connected between the positive electrode and the negative electrode of the second power supply V2; the pulse generation module 30 is configured to generate a first pulse waveform according to a first trigger signal sent by the control module 20 when the control module 20 controls the first switch unit S1 to be turned on; and is configured to generate a second pulse waveform according to a second trigger signal sent by the control module 20 when the control module 20 controls the first switch unit S1 to be turned off; the voltage range of the first pulse waveform is larger than that of the second pulse waveform, and the pulse equivalent frequency of the first pulse waveform is higher than that of the second pulse waveform. In other words, the first pulse waveform is a high-voltage high-frequency pulse, and the second pulse waveform is a low-voltage low-frequency pulse. Optionally, the first power source V1 is a high-voltage dc power source, the second power source V2 is a low-voltage dc power source, and the first voltage output by the first power source V1 is greater than the second voltage output by the second power source V2.
When the first switch unit S1 is turned on, the first power V1 outputs a first voltage, and the pulse generating module 30 generates a first pulse waveform (high voltage high frequency pulse waveform) according to a first trigger signal sent by the control module 20. When the first switching unit S1 is turned off, the second power V2 outputs a second voltage, and the pulse generating module 30 generates a second pulse waveform (low voltage low frequency pulse waveform) according to the second trigger signal sent by the control module 20. The first pulse waveform and the second pulse waveform generated by the pulse generation module 30 act on the targeted cells. Optionally, the control terminal of the first switch unit S1 is electrically connected to the control module 20 through the first trigger unit 1, and the control module 20 is configured to control whether the first switch unit S1 is turned on by outputting a control signal to the first trigger unit 1.
Specifically, when the first switching unit S1 is turned on, the first power V1 outputs a first voltage, and the trigger signal sent by the control module 20 may control the switches in the pulse generating module 30 to open and close, so as to invert the direct current (first voltage) into a first pulse waveform. The voltage range of the first pulse waveform can be changed by changing the amplitude of the first voltage, and the pulse equivalent frequency range, the pulse width range and the pulse output time range of the first pulse waveform can be controlled by controlling the on and off times of the plurality of switches. Further, the voltage range of the first pulse waveform is greater than or equal to-6 kV and less than or equal to 6kV, the pulse equivalent frequency range of the first pulse waveform is greater than or equal to 10kHz and less than or equal to 2MHz, and the pulse width Fan Wei of the first pulse waveform is greater than or equal to 200ns and less than or equal to 2 μs. The control module 20 is configured to control each duration on time of the first switch unit S1 to be greater than or equal to 20 μs and less than or equal to 10ms, so that a pulse output time range of the first pulse waveform is greater than or equal to 20 μs and less than or equal to 10ms. That is, the irreversible electroporation pulse generating system of the invention can generate a high-voltage high-frequency pulse waveform with flexibly adjustable parameter ranges. Similarly, when the first switch unit S1 is turned off, the second power V2 outputs the second voltage, and the trigger signal sent by the control module 20 may control the switches of the pulse generating module 30 to switch on or off, so as to invert the second voltage into the second pulse waveform. The voltage range of the second pulse waveform can be changed by changing the amplitude of the second voltage, and the pulse equivalent frequency range, the pulse width range and the pulse output time range of the second pulse waveform can be controlled by controlling the on and off times of the plurality of switches. Further, the voltage range of the second pulse waveform is greater than or equal to-0.6 kV and less than or equal to 0.6kV, the pulse equivalent frequency range of the second pulse waveform is greater than or equal to 1Hz and less than or equal to 500Hz, the pulse width range of the second pulse waveform is greater than or equal to 1ms and less than or equal to 500ms, and the pulse output time range of the second pulse waveform is greater than or equal to 40ms and less than or equal to 1s. Illustratively, the voltage of the first pulse waveform may be 3kV, the pulse width may be 1 μs, and the pulse equivalent frequency may be 100kHz; the voltage of the second pulse waveform may be 50V, the pulse width may be 50ms, and the pulse equivalent frequency may be 8.33Hz. The interval time between the first pulse waveform and the second pulse waveform may be 10ms. The invention generates a first pulse waveform according to a first trigger signal sent by the control module 20; a second pulse waveform is generated according to a second trigger signal issued by the control module 20. In other words, the invention can generate high-pressure high-frequency pulse waveforms with flexible and adjustable parameter ranges and low-pressure low-frequency pulse waveforms with flexible and adjustable parameter ranges, wherein the high-pressure high-frequency pulse waveforms are used for generating electroporation effect on the premise of not generating muscle contraction, and the low-pressure low-frequency pulse waveforms are used for enhancing the electroporation effect, thereby enhancing tissue ablation effect and enabling tissue ablation to be more thorough. Meanwhile, the waveforms generated by the irreversible electroporation pulse generation system have symmetrical characteristics, so that obvious electrolysis effect cannot be generated, and the safety of clinical application is ensured.
The power selection module 10 further includes an anti-reflection diode D1, wherein an anode of the anti-reflection diode D1 is electrically connected with an anode of the second power V2, and a cathode of the anti-reflection diode D1 is electrically connected with the common terminal of the first switch unit S1 and the pulse generation module 30. The anti-reverse diode D1 has the characteristics of forward conduction and reverse cut-off, and the unidirectional conductivity of the anti-reverse diode D1 can prevent the second power supply V2 from being damaged by impact when the irreversible electroporation pulse generating system outputs the first pulse waveform (high-voltage high-frequency pulse). The power supply selection module 10 further includes a first freewheeling diode D2, where an anode of the first freewheeling diode D2 is connected to a cathode of the anti-reflection diode D1, and a cathode of the first freewheeling diode D2 is electrically connected to an anode of the first power supply V1. Wherein the first freewheeling diode D2 is used for freewheeling.
The irreversible electroporation pulse generating system further comprises a first capacitor C1 and a second capacitor C2, wherein the first capacitor C1 is connected in parallel to two ends of the first power supply V1, and the second capacitor C2 is connected in parallel to two ends of the second power supply V2. The first capacitor C1 and the second capacitor C2 are voltage stabilizing capacitors. The charging energy of the first power source V1 is stored in the first capacitor C1, and the charging energy of the second power source V2 is stored in the second capacitor C2.
The pulse generating module 30 includes a trigger circuit and an H-bridge pulse generating circuit formed by the second switch unit S2, the third switch unit S3, the fourth switch unit S4 and the fifth switch unit S5, where the trigger circuit is electrically connected to the control module 20, the second switch unit S2, the third switch unit S3, the fourth switch unit S4 and the fifth switch unit S5, and the trigger circuit is used for controlling the turn-on time sequence of the second switch unit S2, the third switch unit S3, the fourth switch unit S4 and the fifth switch unit S5 according to the trigger signal issued by the control module 20.
Optionally, the trigger circuit includes a second trigger unit 2 correspondingly connected to the second switch unit S2, a second trigger unit 3 correspondingly connected to the third switch unit S3, and a fourth trigger unit 4 correspondingly connected to the fourth switch unit S4, and a fifth trigger unit 5 correspondingly connected to the fifth switch unit S5.
Specifically, the second switch unit S2 is connected to the second trigger unit 2, the third switch unit S3 is connected to the third trigger unit 3, the fourth switch unit S4 is connected to the fourth trigger unit 4, and the fifth switch unit S5 is connected to the fifth trigger unit 5. The first trigger signal sent by the control module 20 is a set of trigger signals, the second trigger signal is also a set of trigger signals, and the set of trigger signals may include four paths of trigger signals for the second trigger unit 2, the third trigger unit 3, the fourth trigger unit 4 and the fifth trigger unit 5. In an alternative embodiment of the present invention, the control signal and the first trigger signal output by the control module 20 to the power selection module 10 may be used as a set of control signals, and the control signal and the second trigger signal output by the control module 20 to the power selection module 10 may also be used as a set of control signals.
Optionally, the first switching unit S1, the second switching unit S2, the third switching unit S3, the fourth switching unit S4, and the fifth switching unit S5 may be bipolar power transistors, and may also be field effect transistors. The four diodes (first diode D3, second diode D4, third diode D5, fourth diode D6) connected in parallel with the second switching unit S2, third switching unit S3, fourth switching unit S4, and fifth switching unit S5 may be schottky diodes.
When the control signal output by the control module 20 is at a high level, the first switch unit S1 is turned on, the first power V1 is stabilized by the first capacitor C1 and then outputs a first voltage, and the pulse generating module 30 generates a first pulse waveform (high voltage high frequency pulse waveform) according to the first trigger signal sent by the control module 20. When the control signal output by the control module 20 is at a low level, the first switch unit S1 is turned off, the second power V2 is stabilized by the second capacitor C2 and then outputs a second voltage, and the pulse generating module 30 generates a second pulse waveform (low-voltage low-frequency pulse waveform) according to the second trigger signal sent by the control module 20.
The working principle of the H-bridge pulse generating circuit is as follows:
the second switching unit S2 and the fifth switching unit S5 are controlled to be turned on by the trigger signal sent by the control module 20, and the third switching unit S3 and the fourth switching unit S4 are turned off, so that an upper half-shaft portion of the pulse waveform is generated. The second switching unit S2 and the fifth switching unit S5 are controlled to be turned on by the trigger signal sent by the control module 20, and the third switching unit S3 and the fourth switching unit S4 are turned off, so that a lower half shaft portion of the pulse waveform is generated.
FIG. 3 is a schematic diagram of another irreversible electroporation pulse generator system according to an embodiment of the invention.
Referring to fig. 3, optionally, the control module 20 includes a host computer 201, an FPGA unit 202, a signal level enhancing unit 203, and an electro-optical-electrical conversion unit 204, where the host computer 201 is configured to send an initial control signal and an initial trigger signal to the FPGA unit 202, the FPGA unit 202 is configured to enhance the initial control signal by the signal level enhancing unit 203 to obtain the control signal, and enhance the initial trigger signal to obtain the trigger signal, and the signal level enhancing unit 203 is configured to transmit the control signal to the power selection module 10 by the electro-optical-electrical conversion unit 204, and transmit the trigger signal to the second trigger unit 2, the third trigger unit 3, the fourth trigger unit 4, and the fifth trigger unit 5 by the electro-optical-electrical conversion unit 204, so as to prevent the output pulse during the treatment from interfering with the trigger signal.
The upper computer 201 sends a communication instruction to the FPGA unit 202 through a man-machine interaction interface, the FPGA unit 202 enhances a control signal and a trigger signal through the signal level enhancing unit 203 to prevent the control signal from being interfered by an output pulse in the treatment process, for example, the trigger signal sent by the FPGA unit 202 is a 3.3V level signal which is extremely easy to be interfered by electromagnetic interference of a high-voltage high-frequency pulse signal, so that the level needs to be raised (for example, 5V); the raised trigger signals are transmitted to the trigger units in the trigger circuit through the electro-optical-electrical conversion unit 204, and as described above, the trigger signals include four paths of trigger signals for the second trigger unit 2, the third trigger unit 3, the fourth trigger unit 4 and the fifth trigger unit 5, and the trigger signals for different trigger units may be the same or different according to the required pulse waveforms. After the second trigger unit 2 receives the trigger signal sent by the control module 20, whether the second switch unit S2 is turned on or not is controlled according to the received trigger signal; after receiving the trigger signal sent by the control module 20, the third trigger unit 3 controls whether the third switch unit S3 is turned on or not according to the received trigger signal; after receiving the trigger signal sent by the control module 20, the fourth trigger unit 4 controls whether the fourth switch unit S4 is turned on or not according to the received trigger signal; after receiving the trigger signal sent by the control module 20, the fifth trigger unit 5 controls whether the fifth switch unit S5 is turned on according to the received trigger signal, so that the second switch unit S2, the third switch unit S3, the fourth switch unit S4 and the fifth switch unit S5 are turned on according to specific trigger signals respectively, and a pulse waveform is sent to the target tissue.
Optionally, the irreversible electroporation pulse generating system further comprises a power supply module 40, wherein the power supply module 40 comprises a mains power supply 401 and an ac-dc conversion unit 402; the mains supply 401 is electrically connected with the ac-dc conversion unit 402, and the ac-dc conversion unit 402 is electrically connected with the power selection module 10 to provide voltage for the power selection module 10; the power supply module 40 is also electrically connected to the control module 20 to supply power to the control module 20.
The ac-dc conversion unit 402 converts ac power from the utility into dc power, and the dc power is divided into two parts, one part is used for supplying power to the FPGA unit 202; the other part provides power for the first power supply and the second power supply in the power selection module 10. The mains supply 401 is connected to the host computer 201 to supply power to the host computer 201.
Fig. 4 is a schematic diagram of a high-voltage high-frequency bipolar pulse output waveform according to an embodiment of the present invention.
Referring to FIG. 4, the voltage range in the high voltage high frequency pulse waveform is greater than or equal to-3 kV and less than or equal to 3kV, the pulse width is 1 μs, and the pulse equivalent frequency is 100kHz.
Fig. 5 is a schematic diagram of a low-voltage low-frequency bipolar pulse output waveform according to an embodiment of the present invention. Referring to fig. 5, the voltage range in the low voltage low frequency pulse waveform is greater than or equal to-0.1 kV and less than or equal to 0.1kV.
Note that the above is only a preferred embodiment of the present invention and the technical principle applied. It will be understood by those skilled in the art that the present invention is not limited to the particular embodiments described herein, but is capable of various obvious changes, rearrangements and substitutions as will now become apparent to those skilled in the art without departing from the scope of the invention. Therefore, while the invention has been described in connection with the above embodiments, the invention is not limited to the embodiments, but may be embodied in many other equivalent forms without departing from the spirit or scope of the invention, which is set forth in the following claims.
Claims (10)
1. An irreversible electroporation pulse generating system comprising: the device comprises a power supply selection module, a control module and a pulse generation module;
the power supply selection module is electrically connected with the control module and is used for selecting output voltage according to a control signal sent by the control module; the output voltage at least comprises a first voltage and a second voltage, and the first voltage and the second voltage are different in magnitude;
the pulse generation module is respectively and electrically connected with the power supply selection module and the control module and is used for generating bipolar pulse signals according to the trigger signals sent by the control module and the output voltage of the power supply selection module.
2. The irreversible electroporation pulse generation system of claim 1, wherein the power selection module comprises:
a first power supply for outputting the first voltage, a second power supply for outputting the second voltage, and a first switching unit; the first switch unit is connected between the positive poles of the first power supply and the second power supply, and the negative pole of the first power supply is electrically connected with the negative pole of the second power supply; the control end of the first switch unit is electrically connected with the control module;
the pulse generating module is connected between the positive electrode and the negative electrode of the second power supply;
the pulse generation module is used for generating a first pulse waveform according to a first trigger signal sent by the control module when the control module controls the first switch unit to be conducted; the control module is used for generating a second pulse waveform according to a second trigger signal sent by the control module when the control module controls the first switch unit to be turned off;
the voltage range of the first pulse waveform is larger than that of the second pulse waveform, and the pulse equivalent frequency of the first pulse waveform is higher than that of the second pulse waveform.
3. The irreversible electroporation pulse generating system of claim 2, wherein a control terminal of the first switching unit is electrically connected to the control module through a first trigger unit, the control module configured to control whether the first switching unit is turned on by outputting the control signal to the first trigger unit.
4. The irreversible electroporation pulse generation system of claim 2, wherein the voltage range of the first pulse waveform is greater than or equal to-6 kV and less than or equal to 6kV, the pulse equivalent frequency range of the first pulse waveform is greater than or equal to 10kHz and less than or equal to 2MHz, and the pulse width range of the first pulse waveform is greater than or equal to 200ns and less than or equal to 2 μs.
5. The irreversible electroporation pulse generation system of claim 2, wherein the control module is configured to control each duration on time of the first switch unit to be greater than or equal to 20 μs and less than or equal to 10ms such that a pulse output time range of the first pulse waveform is greater than or equal to 20 μs and less than or equal to 10ms.
6. The irreversible electroporation pulse generation system of claim 2, wherein the voltage range of the second pulse waveform is greater than or equal to-0.6 kV and less than or equal to 0.6kV, the pulse equivalent frequency range of the second pulse waveform is greater than or equal to 1Hz and less than or equal to 500Hz, the pulse width range of the second pulse waveform is greater than or equal to 1ms and less than or equal to 500ms, and the pulse output time range of the second pulse waveform is greater than or equal to 40ms and less than or equal to 1s.
7. The irreversible electroporation pulse generation system of claim 2, wherein the control module is further configured to output the off control signal and the on control signal to the first switch unit at a time interval of greater than or equal to 1ms and less than or equal to 10s, and to output the second trigger signal and the first trigger signal to the pulse generation module at a time interval of greater than or equal to 1ms and less than or equal to 10s, such that an interval time between the pulse generation module outputting the second pulse waveform and the first pulse waveform is greater than or equal to 1ms and less than or equal to 10s.
8. The irreversible electroporation pulse generation system of claim 2, wherein the power selection module further comprises an anti-reflection diode, the anode of the anti-reflection diode being electrically connected to the anode of the second power source, the cathode of the anti-reflection diode being electrically connected to the common terminal of the first switching unit and the pulse generation module.
9. The irreversible electroporation pulse generating system of any of claims 1-8, wherein the pulse generating module comprises a trigger circuit and an H-bridge pulse generating circuit consisting of a second switch unit, a third switch unit, a fourth switch unit and a fifth switch unit, the trigger circuit is respectively and electrically connected with the control module, the second switch unit, the third switch unit, the fourth switch unit and the fifth switch unit, and the trigger circuit is used for controlling the conduction time sequence of the second switch unit, the third switch unit, the fourth switch unit and the fifth switch unit according to a trigger signal issued by the control module.
10. The irreversible electroporation pulse generation system of claim 9, wherein the trigger circuit comprises a second trigger unit correspondingly connected to the second switch unit, a third trigger unit correspondingly connected to the third switch unit, a fourth trigger unit correspondingly connected to the fourth switch unit, and a fifth trigger unit correspondingly connected to the fifth switch unit;
the control module comprises a host computer, an FPGA unit, a signal level enhancement unit and an electric-optical-electric conversion unit, wherein the host computer is used for sending an initial control signal and an initial trigger signal to the FPGA unit, the FPGA unit is used for enhancing the initial control signal through the signal level enhancement unit to obtain the control signal and enhancing the initial trigger signal to obtain the trigger signal, the signal level enhancement unit is used for transmitting the control signal to the power supply selection module through the electric-optical-electric conversion unit and transmitting the trigger signal to the second trigger unit, the third trigger unit, the fourth trigger unit and the fifth trigger unit through the electric-optical-electric conversion unit.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202310268238.1A CN116158838A (en) | 2023-03-16 | 2023-03-16 | Irreversible electroporation pulse generation system |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202310268238.1A CN116158838A (en) | 2023-03-16 | 2023-03-16 | Irreversible electroporation pulse generation system |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN116158838A true CN116158838A (en) | 2023-05-26 |
Family
ID=86420199
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202310268238.1A Pending CN116158838A (en) | 2023-03-16 | 2023-03-16 | Irreversible electroporation pulse generation system |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN116158838A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US12076071B2 (en) | 2020-08-14 | 2024-09-03 | Kardium Inc. | Systems and methods for treating tissue with pulsed field ablation |
-
2023
- 2023-03-16 CN CN202310268238.1A patent/CN116158838A/en active Pending
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US12076071B2 (en) | 2020-08-14 | 2024-09-03 | Kardium Inc. | Systems and methods for treating tissue with pulsed field ablation |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US9877771B2 (en) | System and method for power supply noise reduction | |
| EP3111873B1 (en) | Electrosurgical generator for minimizing neuromuscular stimulation | |
| Zeng et al. | A novel high-frequency bipolar pulsed power generator for biological applications | |
| CN110071707B (en) | Cooperative pulse signal generating device | |
| CN219354137U (en) | Irreversible electroporation pulse generation system | |
| CN116158838A (en) | Irreversible electroporation pulse generation system | |
| JP2012223585A (en) | Electrosurgical apparatus with improved incision | |
| CN113440247B (en) | High-frequency irreversible electroporation tumor treatment system | |
| CN115102530B (en) | Electric field generating device and system for inhibiting tumor cells | |
| WO2022218213A1 (en) | Pulse switching signal generating circuit and pulse generating device | |
| CN115252111A (en) | Synchronous bipolar pulse electric field tissue ablation device | |
| CN215528977U (en) | Novel wide-narrow pulse combined high-voltage pulse generator for cell electroporation | |
| CN117042706A (en) | Power unit for delivering coherent sinusoidal burst irreversible electroporation energy to biological tissue | |
| CN113768612B (en) | High voltage transmitting circuit for catheter and ablation instrument | |
| CN113346876A (en) | Pulse generating device and pulse control method | |
| CN114081614A (en) | Pulsed electric field tissue ablation device | |
| WO2024007424A1 (en) | Cardiac pulsed electric field ablation system | |
| CN219439389U (en) | Pulsed electric field therapeutic device | |
| CN215739390U (en) | Switching device for composite radio frequency and irreversible electroporation | |
| CN114343829A (en) | Pulse generating device, ablation device, pulse generating method, and storage medium | |
| CN113437951A (en) | Novel wide-narrow pulse combined high-voltage pulse generator for cell electroporation | |
| CN107947776B (en) | Isolated switching tube driving circuit | |
| Redondo et al. | New repetitive bipolar solid-state Marx type modulator | |
| CN218636068U (en) | Pulse generating device for tissue ablation and cell treatment | |
| CN217612505U (en) | Programmable low-frequency functional electrical stimulation signal generating circuit with electric signal monitoring |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination |