CN114343829A - Pulse generating device, ablation device, pulse generating method, and storage medium - Google Patents
Pulse generating device, ablation device, pulse generating method, and storage medium Download PDFInfo
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- 238000002679 ablation Methods 0.000 title claims abstract description 34
- 238000000034 method Methods 0.000 title claims abstract description 26
- 238000004146 energy storage Methods 0.000 claims description 70
- 238000007599 discharging Methods 0.000 claims description 69
- 230000002441 reversible effect Effects 0.000 claims description 18
- 238000012163 sequencing technique Methods 0.000 claims description 7
- 238000004590 computer program Methods 0.000 claims description 4
- 230000005611 electricity Effects 0.000 claims description 2
- 239000003990 capacitor Substances 0.000 description 32
- 238000010586 diagram Methods 0.000 description 10
- 230000000694 effects Effects 0.000 description 6
- 230000036961 partial effect Effects 0.000 description 4
- 230000005540 biological transmission Effects 0.000 description 3
- 238000013153 catheter ablation Methods 0.000 description 3
- 238000005516 engineering process Methods 0.000 description 3
- 206010003119 arrhythmia Diseases 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000000903 blocking effect Effects 0.000 description 1
- 230000003750 conditioning effect Effects 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
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- 238000003379 elimination reaction Methods 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 230000008014 freezing Effects 0.000 description 1
- 238000007710 freezing Methods 0.000 description 1
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- 230000003902 lesion Effects 0.000 description 1
- 230000000670 limiting effect Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
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- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B18/04—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating
- A61B18/12—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating by passing a current through the tissue to be heated, e.g. high-frequency current
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B2018/00315—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body for treatment of particular body parts
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- A61B2018/00571—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body for achieving a particular surgical effect
- A61B2018/00577—Ablation
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B18/04—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating
- A61B18/12—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating by passing a current through the tissue to be heated, e.g. high-frequency current
- A61B18/1206—Generators therefor
- A61B2018/1246—Generators therefor characterised by the output polarity
- A61B2018/126—Generators therefor characterised by the output polarity bipolar
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Abstract
The invention relates to the technical field of ablation equipment, and discloses a pulse generating device, an ablation device, a pulse generating method and a storage medium, wherein the pulse generating device comprises a control circuit, a power supply circuit and a bipolar pulse source circuit, the bipolar pulse source circuit comprises at least two pulse units and a discharge switching unit, and the pulse units are controlled by the discharge switching unit to output two pulse signals with opposite polarities so as to generate ablation pulses.
Description
Technical Field
The invention relates to the technical field of ablation equipment, in particular to a pulse generating device, an ablation device, a pulse generating method and a storage medium.
Background
Pulse ablation devices have become a common tool for disease treatment, especially for treatment of cardiac arrhythmias, and existing pulse ablation devices mainly use radio frequency, microwave and freezing methods to generate treatment signals, wherein radio frequency technology can generate sine waves with fixed frequency. The generated radio frequency energy acts on a focus point needing treatment through a radio frequency catheter or a radio frequency electrode, so that the focus point can achieve the blocking or conditioning effect, and further achieve the treatment effect, but due to the fixed frequency of the radio frequency energy, the system connected with the radio frequency energy can remove the interference of radio frequency signals on other signals through a band elimination filtering mode. And the heat sink effect is more limited in clinical practical application, and the full-layer transmural ablation target is difficult to achieve, so that the treatment effect is influenced. In addition, since the microwave thermal ablation technique does not provide selectivity for cells, non-target cells are also ablated and destroyed.
At present, no matter which mode is adopted, different pulse generating devices are required to be used for generating the bipolar pulse, and the pulse generating devices generate pulses with different differences, so that the differences are not beneficial to coordinately controlling the output of the bipolar pulse, and certain influence is also generated on the treatment effect of the high-voltage pulse technology.
Disclosure of Invention
The invention mainly aims to solve the problem that the output of the output pulse is difficult to reach the full-layer transmural effect due to the fact that the output of the coordination control bipolar pulse is complex due to the fact that a plurality of pulse generating circuits exist in the existing pulse generating device.
The invention provides in a first aspect a pulse generating device for use in an ablation device, the pulse generating device comprising: the control circuit, the bipolar pulse source circuit and the power supply circuit for supplying power to the bipolar pulse source circuit;
the bipolar pulse source circuit comprises at least two pulse units and a discharge switching unit, wherein the at least two pulse units are connected through the discharge switching unit;
the control circuit is respectively connected with the at least two pulse units and the discharge switching unit and is used for controlling the bipolar pulse source circuit to work in different modes, wherein the modes comprise a charging mode and a discharging mode;
when the bipolar pulse source circuit needs to be charged, the control circuit controls the discharge switching unit to connect the at least two pulse units and the power supply circuit in parallel, and electric energy is obtained from the power supply circuit to store energy;
when the bipolar pulse source circuit needs to discharge, the control circuit controls the discharge switching unit to be connected with an external load, a reverse loop or a forward loop is formed between the discharge switching unit and the at least two pulse units, the at least two pulse units discharge outwards based on the reverse loop or the forward loop, a positive signal and a negative signal are output, and an ablation pulse is constructed based on the positive signal and the negative signal.
Optionally, in a first implementation manner of the first aspect of the present invention, the pulse unit includes an electric storage circuit composed of at least N energy storage devices and a switch circuit composed of 2(N-1) switch devices, where every two energy storage devices are connected end to end through the switch device to form a loop, where N is greater than or equal to 2;
the pulse unit is connected with the power supply circuit, and the power supply circuit is used for transmitting electric energy to the pulse unit and charging at least N energy storage devices in the pulse unit in a charging mode;
the discharge switching unit is connected with the control circuit and used for controlling partial opening and partial closing of 2(N-1) switching devices in the switching circuit based on an instruction of the control circuit and controlling the pulse unit and the load to form a reverse loop or a forward loop so as to realize discharge of the pulse unit.
Optionally, the bipolar pulse source circuit further includes an inductor group and a diode group; when the bipolar pulse source circuit works in a charging mode, the power supply circuit charges the at least two pulse units through the diode group and the inductance group.
Optionally, in a third implementation manner of the first aspect of the present invention, the at least two pulse units include a first pulse unit and a second pulse unit, and the discharge switching unit includes a first switch unit and a second switch unit;
the first switch unit is arranged between the first connecting end of the first pulse unit and the first connecting end of the second pulse unit, and the second switch unit is arranged between the second connecting end of the first pulse unit and the second connecting end of the second pulse unit.
Optionally, in a fourth implementation manner of the first aspect of the present invention, if the first switch unit is turned on and the second switch unit is turned off, the control unit controls opening and closing of 2(N-1) switch devices, connects the N energy storage devices in the first pulse unit and the second pulse unit in the forward direction, and forms a forward loop with the load to perform positive electrode discharge, and outputs a positive polarity pulse signal;
if the first switch unit is disconnected and the second switch unit is connected, the control unit controls the opening and closing of 2(N-1) switch devices, reversely connects the N energy storage devices in the first pulse unit and the second pulse unit, forms a reverse loop with the load to perform negative electrode discharge, and outputs a negative polarity pulse signal.
Optionally, in a fifth implementation manner of the first aspect of the present invention, each of the first pulse unit and the second pulse unit includes a first energy storage device, a second energy storage device, a first switching device, and a second switching device;
the anode of the first energy storage device is connected with the cathode of the second energy storage device through the first switch device, and the cathode of the first energy storage device is connected with the anode of the second energy storage device through the second switch device;
the first switch unit is arranged between the cathode of the second energy storage device of the first pulse unit and the anode of the first energy storage device of the second pulse unit; the second switch unit is arranged between the anode of the second energy storage device of the first pulse unit and the cathode of the first energy storage device in the second pulse unit.
A second aspect of the invention provides an ablation device comprising a pulse generating device as claimed in any one of the preceding claims.
A third aspect of the present invention provides a pulse generating method applied to the pulse generating apparatus described in any one of the above, the bipolar pulse source circuit including a pulse unit and a discharge switching unit, the pulse generating method including:
controlling the control circuit to generate a set of instructions, wherein the set of instructions includes a charge instruction, a first discharge instruction, and a second discharge instruction;
sequencing the charging command, the first discharging command and the second discharging command to obtain a command sequence, and sequentially sending the commands in the command sequence to the bipolar pulse source circuit according to the time sequence;
if the charging instruction is sent to the bipolar pulse source circuit, controlling the discharging switching unit to connect the pulse unit and the power supply circuit based on the charging instruction, and charging the pulse unit;
if the first discharging instruction is sent to the bipolar pulse source circuit, controlling the discharging switching unit to switch on the connection between the pulse unit and a load based on the first discharging instruction, and carrying out positive electrode discharging on the pulse unit to generate a positive electrode pulse signal;
and if the second discharge instruction is sent to the bipolar pulse source circuit, controlling the discharge switching unit to switch on the connection between the pulse unit and the load based on the second discharge instruction, and performing negative discharge on the pulse unit to generate a negative pulse signal.
Optionally, in a first implementation manner of the third aspect of the present invention, the performing time sequence ordering on the charging instruction, the first discharging instruction, and the second discharging instruction to obtain an instruction sequence includes:
acquiring demand parameters of the pulse signals;
respectively calculating the number of positive polarity pulse signals and negative polarity pulse signals in the same period according to the demand parameters, and determining charging time, positive electrode discharging time and negative electrode discharging time based on the number;
and sequencing the charging command, the first discharging command and the second discharging command, and configuring a gap between the two commands based on the charging time, the anode discharging time and the cathode discharging time to obtain a command sequence.
A fourth aspect of the present invention provides a computer-readable storage medium storing a computer program which, when executed by a processor, implements the steps in the pulse generation method provided by the second aspect described above.
Has the advantages that:
compared with the prior art, the pulse generating device has the advantages that two pulses are generated through one circuit structure, due to the fact that the signals are generated under the same circuit result, when the pulses are output in a coordinated control mode, the standard of the coordinated control is the same, the signals are processed more simply, and therefore the problem that the ablation target of a full-layer through wall is difficult to achieve through the existing pulse generating scheme of cardiac ablation is solved.
Drawings
FIG. 1 is a schematic diagram of a first embodiment of a pulse generating device provided by the present invention;
FIG. 2 is a schematic diagram of a second embodiment of a pulse generating device provided in the present invention;
FIG. 3 is a schematic circuit diagram of a bipolar pulse source circuit according to the present invention;
FIG. 4 is a schematic circuit diagram of the bipolar pulse source circuit provided in the present invention in a charging mode;
FIG. 5 is a schematic circuit diagram of the bipolar pulse source circuit provided by the present invention under positive polarity discharge;
FIG. 6 is a schematic circuit diagram of the bipolar pulse source circuit according to the present invention under negative polarity discharge;
FIG. 7 is a waveform diagram of a bipolar pulse signal outputted from the pulse generator according to the present invention;
fig. 8 is a schematic diagram of an embodiment of a pulse generation method provided by the present invention.
Detailed Description
Based on the defects of the traditional pulse generating device, the application provides the pulse generating device capable of generating bipolar pulse signals at the same time, the design of the ablation device is realized through the pulse generating device, so that the ablation device can realize the output of the bipolar pulse signals without arranging a plurality of pulse signal sources, the pulse width and the number of the ablation device can be controlled through a discharge switching unit in a direct bipolar pulse source circuit, and the pulse signals of two polarities are generated through the same circuit, and the signals are identical in other parameters except the opposite polarities, so that the pulse generating device is simpler in coordination control, the development cost of the ablation device is greatly reduced, and the use convenience of a user is improved.
Referring to fig. 1, a first structural schematic diagram of a pulse generator according to an embodiment of the present invention includes a control circuit 110, a power supply circuit 120 and a bipolar pulse source circuit 130, where the power supply circuit 120 is mainly connected in parallel with the bipolar pulse source circuit 130, and is configured to provide a pulse voltage to the bipolar pulse source circuit 130, and the bipolar pulse source circuit 130 is controlled by the control circuit 110 to implement charging or discharging.
In this embodiment, the control circuit 110 is configured to control the bipolar pulse source circuit 130 to operate in different modes, where the modes include a charging mode and a discharging mode;
the bipolar pulse source circuit 130 obtains electric energy from the power supply circuit 120 for energy storage in a charging mode; and in the discharging mode, discharging the stored electric energy to the outside, outputting a positive signal and a negative signal, and constructing an ablation pulse based on the positive signal and the negative signal.
The control circuit 110 is connected to the bipolar pulse source circuit 130, the control circuit 110 controls the power supply circuit 120 to charge the bipolar pulse source circuit 130 after detecting that the voltage in the bipolar pulse source circuit 130 is lower than a set value, until the control circuit 110 detects that the voltage is not lower than the set value, the control circuit 130 controls the bipolar pulse source circuit 130 to discharge, and during discharging, the control circuit 110 outputs different instructions to control the bipolar pulse source circuit 130 to switch different polarities to discharge according to the configured discharge gap, so as to output a bipolar pulse signal.
In this embodiment, the bipolar pulse source circuit 130 includes at least two pulse units 131 and a discharge switching unit 132, and at least two pulse units 131 are connected through the discharge switching unit 132;
the control circuit 110 is respectively connected to the at least two pulse units 131 and the discharge switching unit 132, and is configured to control the bipolar pulse source circuit 130 to operate in different modes, where the modes include a charging mode and a discharging mode;
when the bipolar pulse source circuit 130 needs to be charged, the control circuit 110 controls the discharging switching unit 132 to connect the at least two pulse units 131 in parallel with the power supply circuit 120, and obtains electric energy from the power supply circuit 120 to store energy;
when the bipolar pulse source circuit 130 needs to discharge, the control circuit 110 controls the discharge switching unit 132 to be connected with an external load, a reverse loop or a forward loop is formed with the at least two pulse units 131, the at least two pulse units 131 discharge outwards based on the reverse loop or the forward loop, a positive signal and a negative signal are output, and an ablation pulse is constructed based on the positive signal and the negative signal.
In this embodiment, the pulse unit 131 includes a switch circuit 1311 composed of 2(N-1) switch devices and an energy storage circuit 1312 composed of at least N energy storage devices, where each two energy storage devices are connected end to end through the switch device to form a loop, where N is greater than or equal to 2, and the switch circuit 1311 is embedded in the energy storage circuit 1312 to implement end to end connection of the energy storage devices in the energy storage circuit 1312, where end to end connection is understood as connection of an anode of one energy storage device with a cathode of another energy storage device.
Specifically, the energy storage circuit 1312 is connected to the power supply circuit 120, and is configured to, in a charging mode, enable the power supply circuit 120 to transmit electric energy to the energy storage circuit 1312 to charge the energy storage circuit 1312; optionally, the power supply circuit 120 is connected in parallel with the energy storage circuit 1312, that is, the positive and negative poles of the power supply circuit 120 are connected with the input and output terminals of the energy storage circuit 1312.
The switch circuit 1311 is connected to the control circuit 110, and is configured to control partial opening and partial closing of 2(N-1) switch devices in the switch circuit 1311 based on an instruction of the control circuit 110, and control the pulse unit 131 to form a reverse loop or a forward loop with the load, so as to achieve discharging of the pulse unit 131. Specifically, the control circuit 110 controls each switch circuit 1311 to be turned on, and performs reverse connection or forward connection on N energy storage devices in each pulse unit 131, and controls the discharge switching unit 132 to be turned on, so as to form a reverse loop or a forward loop with the at least two pulse units 131 and an external load, where the at least two pulse units 131 discharge outwards based on the reverse loop or the forward loop, output a positive signal and a negative signal, and construct an ablation pulse based on the positive signal and the negative signal.
In practical application, the switch circuit 1311 is a multi-switch combination circuit, the output terminal of the control circuit 110 is connected to the control terminal of the switch circuit 1311, the output terminal and the input terminal of the switch circuit 1311 are connected to the input terminal and the output terminal of the energy storage circuit 1312, the control circuit 110 generates a corresponding command according to a configured mode and outputs the command to the control terminal, and then the switch circuit 1311 turns on a corresponding pin based on the received command to implement the operation in the corresponding mode.
As shown in fig. 2, the bipolar pulse source circuit 130 further includes an inductor group 133 and a diode group 134, the inductor group 133 and the diode group 134 are connected in series and then disposed between the power supply circuit 120 and the pulse unit 131, and when the bipolar pulse source circuit 130 operates and is in the charging mode, the power supply circuit 120 charges at least two pulse units 131 through the inductor group 133 and the diode group 134. Wherein the inductor bank 133 comprises at least N series connected inductors, each inductor having an output connected in series with one energy storage device.
In practical applications, the inductance group 133 includes a first inductance circuit 1331 and a second inductance circuit 1332, the diode group 134 includes a first diode 1341 and a second diode 1342, when the at least two pulse units 131 are two, that is, the bipolar pulse source circuit 130 includes a first pulse unit 131a and a second pulse unit 131b, the discharge switching unit 132 includes a first switch unit 1321 and a second switch unit 1322;
the first switch unit 1321 is disposed between the first connection end of the first pulse unit 131a and the first connection end of the second pulse unit 131b, and the second switch unit 1322 is disposed between the second connection end of the first pulse unit 131a and the second connection end of the second pulse unit 131 b.
If the first switch unit 1321 is turned on and the second switch unit 1322 is turned off, the control unit 110 controls the opening and closing of 2(N-1) switch devices, connects the N energy storage devices in the first pulse unit 131a and the second pulse unit 131b in the forward direction, forms a forward loop with the load to perform positive electrode discharge, and outputs a positive polarity pulse signal;
if the first switch unit 1321 is turned off and the second switch unit 1322 is turned on, the control unit 110 controls the opening and closing of 2(N-1) switch devices, reversely connects the N energy storage devices in the first pulse unit 131a and the second pulse unit 131b, and forms a reverse loop with the load to perform negative electrode discharge, and outputs a negative polarity pulse signal.
In this embodiment, the power supply circuit 110 is composed of two dc power supplies, one of which is connected to the first pulse unit 131a and the other of which is connected to the second pulse unit 131b, and the two dc power supplies are connected in series.
Further, the number of the first pulse unit 131a and the second pulse unit 131b arranged in the pulse unit 132 is at least one, and if there are more than two, the first pulse unit 131a and the second pulse unit 131b are arranged at intervals, and the positive and negative electrodes of the two are opposite to each other, and are connected through the first switch unit 1321 or the second switch unit 1322.
In practical applications, each pulse unit 131 includes at least two energy storage devices, and two of them are described below as examples.
In this embodiment, the first pulse unit 131a and the second pulse unit 131b each include a first energy storage device Cn, a second energy storage device Cm, a first switching device S and a second switching device S';
the anode of the first energy storage device Cn is connected with the cathode of the second energy storage device Cm through the first switching device S, and the cathode of the first energy storage device Cn is connected with the anode of the second energy storage device Cm through the second switching device S';
the first switch unit 1321 is disposed between the negative electrode of the second energy storage device Cm of the first pulse unit 131a and the positive electrode of the first energy storage device Cn of the second pulse unit 131 b; the second switch unit 1322 is disposed between the anode of the second energy storage device Cm of the first pulse unit 131a and the cathode of the first energy storage device Cn in the second pulse unit 131 b.
At this time, when a forward loop needs to be formed, the control circuit 110 controls the first switching unit 1321 and the first switching device S to be closed; when it is required to form a reverse loop, the control circuit 110 controls the second switching unit 1322 and the second switching device S' to be closed.
In practical applications, if the energy storage device is a capacitor, and the switch unit and the switch device are single-pole single-gate switches, the bipolar pulse source circuit 130 will be described in detail below by taking an example in which six single-pole single-gate switches (S1 ', S2', S3 ', S4', S5 ', and S6') are provided, and six single-pole single-gate switches (S1, S2, S3, S4, S5, and S6) are provided, the first energy storage device is provided with 4 capacitors (C1, C3, C5, and C7) and the second energy storage device is provided with 3 capacitors (C2, C4, and C6).
As shown in fig. 3, the bipolar pulse source circuit 130 includes two dc power sources (U1 and U2), four inductors (L1, L2, L3, L4, L5, L6, and L7), two diodes (D1 and D2), six second switches (S1 ', S2', S3 ', S4', S5 ', and S6'), six first switches (S1, S2, S3, S4, S5, and S6), 4 first capacitors (C1, C3, C5, and C7), and 3 second capacitors (C2, C4, and C6).
The anode of the direct current power supply U1 is connected with the anode of the diode D1, the cathode of the diode D1 is connected with one end of the inductors L2, L4 and L6 which are connected in series, the inductor L6 is connected with the anode of the capacitor C6, the cathode of the capacitor C6 is connected with one end of a load through a switch S6 ', the other end of the load is connected with the cathode of the direct current power supply U1, and the cathode of the capacitor C6 is connected with the cathode of the direct current power supply U1 through switches S5, S4 ', S3, S2 ' and S1; one end of the inductor L2 connected with the inductor L4 is connected with the anode of the capacitor C2, and the cathode of the capacitor C2 is connected with one end of the switches S2' and S1; one end of the inductor L4 connected with the inductor L6 is connected with the anode of the capacitor C4, and the cathode of the capacitor C4 is connected with one end of the switches S4' and S3.
The negative electrode of the direct current power supply U2 is connected with the negative electrode of the diode D2, the positive electrode of the diode D2 is connected with one end of the inductors L1, L3, L5 and L7 which are connected in series, the inductor L7 is connected with the negative electrode of the capacitor C7, the positive electrode of the capacitor C7 is connected with one end of a load, the other end of the load is connected with the positive electrode of the direct current power supply U2, and the positive electrode of the capacitor C7 is connected with the positive electrode of the direct current power supply U2 through the switches S6 ', S5, S4 ', S3, S2 ' and S1; one end of the inductor L1 connected with the inductor L3 is connected with the negative electrode of the capacitor C1, and the positive electrode of the capacitor C1 is connected with the positive electrode of the direct-current power supply U2; one end of the inductor L3 connected with the inductor L5 is connected with the negative electrode of the capacitor C3, and the positive electrode of the capacitor C3 is connected with one end of the switches S2' and S3; one end of the inductor L5 connected with the inductor L7 is connected with the negative electrode of the capacitor C5, and the positive electrode of the capacitor C5 is connected with one end of the switches S4' and S5; the negative pole of the direct current power supply U1 is connected with the positive pole of the direct current power supply U2, and the negative pole of the direct current power supply U1 is grounded.
In this embodiment, if the control circuit 110 issues a charging command, the command controls the first energy storage unit and the second energy storage unit to operate in the charging mode, that is, the switches S1, S2 ', S3, S4 ', S5, and S6 ' are controlled to be turned on, the remaining switches are turned off, and the dc power supplies U1 and U2 charge all the capacitors C1, C2, C3, C4, C5, C6, and C7 through respective inductors (L1, L2, L3, L4, L5, L6, and L7), and the specific circuit structure is as shown in fig. 4.
If the control circuit 110 issues the first discharging command, the first discharging command is a positive polarity discharging command, and the first energy storage unit and the second energy storage unit are controlled to operate in the positive polarity discharging mode by the command, that is, the switches S1, S2, S3, S4, S5, and S6 are controlled to be turned on, the remaining switches are turned off, the inductor is in the isolated state, and at this time, the capacitors C2 to C7 are connected in series to discharge the load resistor, and the voltage across the load resistor is positive polarity, and the specific circuit structure is as shown in fig. 5.
If the control circuit 110 issues the second discharging command, the specific second discharging command is a negative discharging command, and the first energy storage unit and the second energy storage unit are controlled to operate in the negative discharging mode by the command, that is, the switches S1 ', S2', S3 ', S4', S5 ', S6' are controlled to be turned on, the remaining switches are turned off, the inductor is in the isolated state, and at this time, the capacitors C1 to C6 are connected in series in reverse to discharge to the load resistor, and the voltage across the load resistor is negative, and the specific circuit structure is as shown in fig. 6.
Based on the interval transmission of the charging command, the first discharging command and the second discharging command by the control circuit 110, the forward series connection and the reverse series connection of the capacitors C1, C2, C3, C4, C5, C6 and C7 are realized, so that the output of the bipolar pulse signal of the bipolar pulse source circuit 130 is realized, and the control of the pulse width and the number of pulses is realized by controlling the transmission time interval of the three commands, so that ablation pulses are obtained, and the waveform of the ablation pulses is shown in fig. 7.
In conclusion, the bipolar pulse source circuit is arranged to output the bipolar pulse signal, so that the positive and negative bipolar pulses can be output by using the same circuit, and the pulse width, the pulse interval and the pulse number of the positive and negative pulses can be independently adjusted without mutual interference.
In this application, in order to better solve the problems of the conventional pulse generating device, the present application further provides a pulse generating method, please refer to fig. 8, which is an embodiment of the pulse generating method provided in this embodiment, the pulse generating method is provided based on the pulse generating device provided in the foregoing embodiment, and the pulse generating device includes: the control circuit, the power supply circuit and the bipolar pulse source circuit are provided with a pulse unit and a discharge switching unit, and the specific implementation steps comprise:
801. the control circuit is controlled to generate a charging instruction, a first discharging instruction and a second discharging instruction;
in this step, the charging command is used to control the bipolar pulse source circuit to operate in a charging mode, so that the bipolar pulse source circuit can store the electric energy provided by the power supply circuit. The first discharge instruction is used for controlling the bipolar pulse source circuit to work in a positive polarity discharge mode, controlling a plurality of capacitors in the pulse unit to be connected in series in a positive direction and forming a loop with the load, and realizing discharge of the capacitors. The second discharge instruction is used for controlling the bipolar pulse source circuit to work in a negative polarity discharge mode, and controlling a plurality of capacitors in the pulse unit to be connected in series in an opposite direction to form a loop with the load so as to realize the discharge of the capacitors.
In this embodiment, the control circuit further sets the transmission time of each command when generating the command, that is, the control circuit configures the pulse width and the number of pulses of the pulse based on the ablation demand of the ablation device for the lesion, and outputs the control time of the command together with the command based on the data.
802. Sequencing the charging command, the first discharging command and the second discharging command to obtain a command sequence, and sequentially sending the commands in the command sequence to the bipolar pulse source circuit according to the time sequence;
specifically, the performing time sequence sequencing on the charging command, the first discharging command, and the second discharging command to obtain a command sequence includes:
acquiring demand parameters of the pulse signals;
respectively calculating the number of positive polarity pulse signals and negative polarity pulse signals in the same period according to the demand parameters, and determining charging time, positive electrode discharging time and negative electrode discharging time based on the number;
and sequencing the charging command, the first discharging command and the second discharging command, and configuring a gap between the two commands based on the charging time, the anode discharging time and the cathode discharging time to obtain a command sequence.
803. And operating the bipolar pulse source circuit based on the instructions in the instruction sequence, and outputting a bipolar pulse signal.
In this step, if the charging instruction is sent to the bipolar pulse source circuit, the discharging switching unit is controlled to connect the pulse unit with the power supply circuit based on the charging instruction, and the pulse unit is charged;
if the first discharging instruction is sent to the bipolar pulse source circuit, controlling the discharging switching unit to switch on the connection between the pulse unit and a load based on the first discharging instruction, and carrying out positive electrode discharging on the pulse unit to generate a positive electrode pulse signal;
and if the second discharge instruction is sent to the bipolar pulse source circuit, controlling the discharge switching unit to switch on the connection between the pulse unit and the load based on the second discharge instruction, and performing negative discharge on the pulse unit to generate a negative pulse signal.
In this embodiment, the instruction sequence includes a charging instruction, a first discharging instruction, a second discharging instruction, and a time interval of each instruction; based on the time interval, the bipolar pulse source circuit is controlled to operate based on a corresponding command, switches S1, S2 ', S3, S4 ', S5 and S6 ' are turned on under a charging command, and the remaining switches are turned off, so that all capacitors C1, C2, C3, C4, C5, C6 and C7 of the pulse generation circuit are charged in a charging mode.
After the time interval for detecting charging is reached, the switches S1, S2, S3, S4, S5 and S6 are turned on based on the first discharge command, and the rest switches are turned off, so that the circuit is in a positive polarity discharge mode, and at the moment, the capacitors C2-C7 are connected in series to discharge to the heart part of the patient, and positive polarity electric pulses are output.
After the detection discharge time interval is reached, the switches S1 ', S2', S3 ', S4', S5 ', S6' are turned on based on the second discharge command, and the rest switches are turned off, so that the circuit is in a negative polarity discharge mode, and at the moment, the capacitors C1-C6 are reversely connected in series to discharge electricity to the heart part of the patient, and negative polarity electric pulses are output. The waveform of the bipolar pulse output at this time is shown in fig. 7.
Further, the pulse width of the positive polarity pulse can be controlled by controlling the on-time of the switches S1, S2, S3, S4, S5 and S6, the pulse width of the negative polarity pulse can be controlled by controlling the on-time of the switches S1 ', S2', S3 ', S4', S5 'and S6', and the pulse widths of the positive and negative bipolar pulses can be independently controlled by controlling the on-time of the switches without interfering with each other.
Further, during the switching from the positive polarity discharge mode to the negative polarity discharge mode, the pulse interval time of the positive polarity pulse and the negative polarity pulse may be controlled by controlling the switching time of the open switches S1, S2, S3, S4, S5, S6 to the on switches S1 ', S2', S3 ', S4', S5 ', S6'.
Furthermore, the number of the pulses of the positive polarity pulses can be controlled by controlling the conducting times of the switches S1, S2, S3, S4, S5 and S6, the number of the pulses of the negative polarity pulses can be controlled by controlling the conducting times of the switches S1 ', S2', S3 ', S4', S5 'and S6', and the number of the pulses of the positive and negative bipolar pulses can be independently controlled by controlling the conducting times of the switches without interference.
Further, the on and off of the switches S1, S2, S3, S4, S5, S6, S1 ', S2', S3 ', S4', S5 ', and S6' in the circuit configuration diagram of the pulse generator may be manually controlled or automatically controlled by a relay.
In conclusion, the working modes of the bipolar pulse source circuit in the pulse generating device are controlled by outputting different instructions so as to output pulse signals with different polarities, and the signals output by the same bipolar pulse source circuit are based on, so that the output of bipolar pulses is favorably coordinated and controlled during ablation, and the treatment effect of the high-voltage pulse technology applied to cardiac ablation is positively influenced. And the pulse width, the pulse interval and the pulse number of the positive polarity pulse and the negative polarity pulse can be controlled by controlling the conduction time of a switch in the bipolar pulse source circuit without mutual interference, thereby effectively solving the problem that the existing pulse generation scheme for cardiac ablation is difficult to achieve the ablation target of full-layer transmural ablation.
Embodiments of the present invention also provide an ablation device, wherein the ablation device includes a pulse generation device as provided in the above embodiments.
Embodiments of the present invention also provide a computer-readable storage medium, which may be a non-volatile computer-readable storage medium or a volatile computer-readable storage medium, where instructions or a computer program are stored in the computer-readable storage medium, and when the instructions or the computer program are executed, a computer executes the steps of the pulse generation method provided in the foregoing embodiments.
It is clear to those skilled in the art that, for convenience and brevity of description, the specific working processes of the above-described systems, apparatuses, and units may refer to the corresponding processes in the foregoing method embodiments, and are not described herein again.
The integrated unit, if implemented in the form of a software functional unit and sold or used as a stand-alone product, may be stored in a computer readable storage medium. Based on such understanding, the technical solution of the present invention may be embodied in the form of a software product, which is stored in a storage medium and includes instructions for causing a computer device (which may be a personal computer, a server, or a network device) to execute all or part of the steps of the method according to the embodiments of the present invention. And the aforementioned storage medium includes: various media capable of storing program codes, such as a usb disk, a removable hard disk, a read-only memory (ROM), a Random Access Memory (RAM), a magnetic disk, or an optical disk.
The terms "first," "second," "third," "fourth," and the like in the description and in the claims, as well as in the drawings, if any, are used for distinguishing between similar elements and not necessarily for describing a particular sequential or chronological order. It will be appreciated that the data so used may be interchanged under appropriate circumstances such that the embodiments described herein may be practiced otherwise than as specifically illustrated or described herein. Furthermore, the terms "comprises," "comprising," or "having," and any variations thereof, are intended to cover non-exclusive inclusions, such that a process, method, system, article, or apparatus that comprises a list of steps or elements is not necessarily limited to those steps or elements expressly listed, but may include other steps or elements not expressly listed or inherent to such process, method, article, or apparatus.
The above-mentioned embodiments are only used for illustrating the technical solutions of the present invention, and not for limiting the same; although the present invention has been described in detail with reference to the foregoing embodiments, it will be understood by those of ordinary skill in the art that: the technical solutions described in the foregoing embodiments may still be modified, or some technical features may be equivalently replaced; and such modifications or substitutions do not depart from the spirit and scope of the corresponding technical solutions of the embodiments of the present invention.
Claims (10)
1. A pulse generating device for use in an ablation device, the pulse generating device comprising: the control circuit, the bipolar pulse source circuit and the power supply circuit for supplying power to the bipolar pulse source circuit;
the bipolar pulse source circuit comprises at least two pulse units and a discharge switching unit, wherein the at least two pulse units are connected through the discharge switching unit; the pulse unit comprises an electricity storage circuit consisting of at least N energy storage devices and a switch circuit consisting of 2(N-1) switch devices, every two energy storage devices are connected end to end through the switch devices to form a loop, wherein N is more than or equal to 2;
the control circuit is respectively connected with the switch circuit and the discharge switching unit in the at least two pulse units and is used for controlling the bipolar pulse source circuit to work in different modes, wherein the modes comprise a charging mode and a discharging mode;
when the bipolar pulse source circuit needs to be charged, the control circuit controls the discharge switching unit and each switch circuit to connect the at least two pulse units and the power supply circuit in parallel, and electric energy is obtained from the power supply circuit for storing energy;
when the bipolar pulse source circuit needs to discharge, the control circuit controls the switch circuits to be switched on, the N energy storage devices in each pulse unit are connected in a reverse direction or a forward direction, the discharge switching unit is controlled to be switched on, the at least two pulse units and an external load form a reverse loop or a forward loop, the at least two pulse units discharge outwards based on the reverse loop or the forward loop, positive signals and negative signals are output, and ablation pulses are constructed based on the positive signals and the negative signals.
2. The pulse generating apparatus of claim 1, wherein the bipolar pulse source circuit further comprises an inductor bank and a diode bank; when the bipolar pulse source circuit works in a charging mode, the power supply circuit charges the at least two pulse units through the diode group and the inductance group.
3. A pulse generating device according to claim 2, wherein the set of inductors comprises at least N series-connected inductors, each inductor having an output connected in series with one energy storage device.
4. The pulse generating apparatus according to claim 1, wherein the at least two pulse units include a first pulse unit and a second pulse unit, and the discharge switching unit includes a first switching unit and a second switching unit;
the first switch unit is arranged between the first connecting end of the first pulse unit and the first connecting end of the second pulse unit, and the second switch unit is arranged between the second connecting end of the first pulse unit and the second connecting end of the second pulse unit.
5. A pulse generating device as defined in claim 4, wherein the first pulse unit and the second pulse unit each comprise a first energy storage device, a second energy storage device, a first switching device and a second switching device;
the anode of the first energy storage device is connected with the cathode of the second energy storage device through the first switch device, and the cathode of the first energy storage device is connected with the anode of the second energy storage device through the second switch device;
the first switch unit is arranged between the cathode of the second energy storage device of the first pulse unit and the anode of the first energy storage device of the second pulse unit; the second switch unit is arranged between the anode of the second energy storage device of the first pulse unit and the cathode of the first energy storage device in the second pulse unit.
6. The pulse generator according to claim 1, wherein if the first switching unit is turned on and the second switching unit is turned off, the control unit controls the opening and closing of 2(N-1) switching devices, connects the N energy storage devices in the first pulse unit and the second pulse unit in a forward direction, forms a forward loop with the load to perform positive electrode discharge, and outputs a positive polarity pulse signal;
if the first switch unit is disconnected and the second switch unit is connected, the control unit controls the opening and closing of 2(N-1) switch devices, reversely connects the N energy storage devices in the first pulse unit and the second pulse unit, forms a reverse loop with the load to perform negative electrode discharge, and outputs a negative polarity pulse signal.
7. An ablation device comprising a pulse generating device according to any one of claims 1-6.
8. A pulse generation method applied to the pulse generation apparatus according to any one of claims 1 to 6, wherein the bipolar pulse source circuit includes a pulse unit and a discharge switching unit, the pulse generation method comprising:
controlling the control circuit to generate a set of instructions, wherein the set of instructions includes a charge instruction, a first discharge instruction, and a second discharge instruction;
sequencing the charging command, the first discharging command and the second discharging command to obtain a command sequence, and sequentially sending the commands in the command sequence to the bipolar pulse source circuit according to the time sequence;
if the charging instruction is sent to the bipolar pulse source circuit, controlling the discharging switching unit to connect the pulse unit and the power supply circuit based on the charging instruction, and charging the pulse unit;
if the first discharging instruction is sent to the bipolar pulse source circuit, controlling the discharging switching unit to switch on the connection between the pulse unit and a load based on the first discharging instruction, and carrying out positive electrode discharging on the pulse unit to generate a positive electrode pulse signal;
and if the second discharge instruction is sent to the bipolar pulse source circuit, controlling the discharge switching unit to switch on the connection between the pulse unit and the load based on the second discharge instruction, and performing negative discharge on the pulse unit to generate a negative pulse signal.
9. The pulse generating method according to claim 8, wherein the time-sequentially ordering the charging command, the first discharging command, and the second discharging command to obtain a command sequence comprises:
acquiring demand parameters of the pulse signals;
respectively calculating the number of positive polarity pulse signals and negative polarity pulse signals in the same period according to the demand parameters, and determining charging time, positive electrode discharging time and negative electrode discharging time based on the number;
and sequencing the charging command, the first discharging command and the second discharging command, and configuring a gap between the two commands based on the charging time, the anode discharging time and the cathode discharging time to obtain a command sequence.
10. A computer-readable storage medium, on which a computer program is stored which, when being executed by a processor, carries out the steps of the pulse generation method according to claim 8 or 9.
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