CN116138717A - 出光角度可调的可视化光热治疗内窥镜装置 - Google Patents
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Abstract
本发明公开了一种出光角度可调的可视化光热治疗内窥镜装置，包括荧光内窥镜(2)、光学适配器(3)、导光光缆(4)、荧光冷光源(5)、荧光摄像系统主机(6)和显示器(7)，荧光冷光源(5)包括白光发光模块(52)、白光准直透镜组(53)、红外发光模块(54)、红外光准直透镜组(55)、位移控制模块(56)、合光镜片(57)和聚光透镜组(58)。本装置将光热治疗和内窥镜诊断相结合，具有白光照明、白光成像、荧光成像、光热治疗、出光角度可调的功能，能对肿瘤细胞快速筛查、减小对正常组织的光辐射损害。
Description
技术领域
本发明属于光热治疗设备领域，具体涉及一种出光角度可调的可视化光热治疗内窥镜装置。
背景技术
作为恶性肿瘤的主要治疗手段，放疗和化疗目前仅仅起到了极低的治疗效果，却伴随有高的毒副作用，这使得癌症治癒率维持在一个极低的水平。光热治疗是一种治疗癌症的全新思路，将具有光热转换的材料，选择性累积到肿瘤部位，然后仅对肿瘤局部实施近红外光照，肿瘤细胞间和细胞内的纳米材料吸收近红外光，高效地转化为热能，可使肿瘤产生局部超高温度，从而轻易将肿瘤细胞杀死，肿瘤周围正常组织纳米材料分布极少，在近红外照射下不会产生过高温度，因此，光热治疗保证了治疗中不会对正常组织造成损伤，显著提高了热疗的安全与有效性。但是，光热治疗的关键为照射光，如何将光线由体外导入体内照明，如何实现肿瘤的微创化精准治疗，减小对正常组织的光辐射损害，是需要解决的问题。
发明内容
本发明的目的是提供一种出光角度可调的可视化光热治疗内窥镜装置，本装置将光热治疗和内窥镜诊断相结合，具有白光照明、白光成像、荧光成像、光热治疗、出光角度可调的功能，能对肿瘤细胞快速筛查、减小对正常组织的光辐射损害。
本发明所采用的技术方案是：
一种出光角度可调的可视化光热治疗内窥镜装置，包括能发射白光和红外光的荧光冷光源(5)，荧光冷光源(5)的出射光线经导光光缆(4)导入荧光内窥镜(2)中的光纤并从荧光内窥镜(2)头端出射，荧光内窥镜(2)能接收反射的白光及激发的荧光，荧光内窥镜(2)的接收光线经光学适配器(3)和荧光摄像系统主机(6)成像后由显示器(7)显示图像，光学适配器(3)采用双光路分别接收白光图像和荧光图像从而能在成像后分别显示；荧光冷光源(5)包括白光发光模块(52)和红外发光模块(54)，白光发光模块(52)和红外发光模块(54)发射的光线先经过各自的准直透镜组(53、55)调整发散角度，再经过合光镜片(57)合光沿同一方向出射，最后经聚光透镜组(58)汇聚至导光光缆(4)，位移控制模块(56)控制红外光准直透镜组(55)垂直于红外发光模块(54)光轴向移动。
优选地，红外发光模块(54)的光谱范围是1000nm-1700nm。
优选地，位移控制模块(56)控制红外光准直透镜组(55)垂直于红外发光模块(54)光轴向移动时，当红外光准直透镜组(55)位于红外光路中时，红外光线角度集中在±10°之间，当红外光准直透镜组(55)离开红外光路时，红外光线角度集中在±40°之间。
优选地，荧光冷光源(5)能选择单独输出白光、单独输出红外光、同时输出白光和红外光。
优选地，白光发光模块(52)和红外发光模块(54)上分别配有散热器(51)。
优选地，合光镜片(57)镀有合光膜，能透射白光、反射红外光。
优选地，荧光图像以伪色彩图的形式显示。
优选地，白光发光模块(52)的光谱范围是400nm-700nm。
优选地，白光发光模块(52)采用LED或LD灯珠。
本发明产生的有益效果是：
本装置将光热治疗和内窥镜诊断相结合，具有白光照明、白光成像、荧光成像、光热治疗、出光角度可调的功能，既能用于常规内窥式手术，又能配合具有光热转换性能的外源性荧光物质，实现对肿瘤细胞的快速筛查和光热治疗，光线大角度出射时，对体内肿瘤组织的快速筛查，可实现大范围筛查，快速省时，光线小角度出射时，光线能量更加集中，能够对肿瘤部位实现精准光热治疗，治疗时长短并避免对正常组织的光辐射伤害。
附图说明
图1是本发明实施例中出光角度可调的可视化光热治疗内窥镜装置的示意图。
图2是本发明实施例中荧光冷光源的内部光路示意图。
图3是本发明实施例中红外光大角度出射时光强分布图。
图4是本发明实施例中红外光小角度出射时光强分布图。
图中：1-待观察目标；2-荧光内窥镜；3-光学适配器；4-导光光缆；5-荧光冷光源；51-散热器；52-白光发光模块；53-白光准直透镜组；54-红外发光模块；55-红外光准直透镜组；56-位移控制模块；57-合光镜片；58-聚光透镜组；6-荧光摄像系统主机；7-显示器。
具体实施方式
下面结合附图和实施例对本发明作进一步说明。
如图1和图2所示，一种出光角度可调的可视化光热治疗内窥镜装置，包括能发射白光和红外光的荧光冷光源5，荧光冷光源5的出射光线经导光光缆4导入荧光内窥镜2中的光纤并从荧光内窥镜2头端出射，荧光内窥镜2能接收反射的白光及激发的荧光，荧光内窥镜2的接收光线经光学适配器3和荧光摄像系统主机6成像后由显示器7显示图像，光学适配器3采用双光路分别接收白光图像和荧光图像从而能在成像后分别显示；荧光冷光源5包括白光发光模块52和红外发光模块54，白光发光模块52和红外发光模块54发射的光线先经过各自的准直透镜组53、55调整发散角度，再经过合光镜片57合光沿同一方向出射，最后经聚光透镜组58汇聚至导光光缆4，位移控制模块56控制红外光准直透镜组55垂直于红外发光模块54光轴向移动。
本装置将光热治疗和内窥镜诊断相结合，具有白光照明、白光成像、荧光成像、光热治疗、出光角度可调的功能，既能用于常规内窥式手术——在内窥镜手术过程中，医务人员利用内窥镜经人体自然腔道或细小手术切口进入人体，借助冷光源的高亮度照射，可实现对体内器官的诊断；又能配合具有光热转换性能的外源性荧光物质，实现对肿瘤细胞的快速筛查和光热治疗——该物质可以为纳米材料等对生物体无害的材料，该物质被注射或以其他方式作用于患者体内，在肿瘤部位形成富集，用红外光对肿瘤组织进行照射时，激发组织中荧光团发光发热，形成荧光图像，并对肿瘤部位进行加热，并进一步杀死肿瘤细胞；光线大角度出射时，对体内肿瘤组织的快速筛查，可实现大范围筛查，快速省时，光线小角度出射时，光线能量更加集中，能够对肿瘤部位实现精准光热治疗，治疗时长短并避免对正常组织的光辐射伤害。
在本实施例中，红外发光模块54的光谱范围是1000nm-1700nm。荧光成像和光热治疗选用近红外二区，即1000nm-1700nm的光线，在生物组织内该波段的光散射和吸收都较小，组织自发荧光现象也可忽略，此外，近红外二区荧光成像可提供高分辨率、高信噪比和深层组织的活体成像，基于此波段进行光热治疗也可提升深部组织肿瘤的治疗效果。
在本实施例中，位移控制模块56控制红外光准直透镜组55垂直于红外发光模块54光轴向移动时，可根据肿瘤大小调整红外光准直透镜组55的位置，当红外光准直透镜组55离开红外光路时，红外光出射角度较大，红外光线角度主要集中在±40°之间，其光强与出射角度分布示意图如图3所示，可以获得更大的观察区域，便于做病灶观察和监测；当红外光准直透镜组55位于红外光路中时，红外光出射角度变小，红外光线角度主要集中在±10°之间，其光强与出射角度分布示意图如图4所示，光线能量更加集中，便于局部光热治疗，可缩短手术时长并避免对正常组织的光辐射伤害。
在本实施例中，荧光冷光源5能选择单独输出白光、单独输出红外光、同时输出白光和红外光。单独输出白光时，整个装置作为普通的内窥镜使用；单独输出红外光时，整个装置配合外源性荧光物质，可实现对肿瘤细胞的快速筛查和光热治疗；同时输出白光和红外光时，白光用于体内照明，红外光用于配合外源性荧光物质实现对肿瘤细胞的快速筛查和光热治疗。
如图2所示，在本实施例中，白光发光模块52和红外发光模块54上分别配有散热器51。
在本实施例中，合光镜片57镀有合光膜，能透射白光、反射红外光。
在本实施例中，荧光图像以伪色彩图的形式显示。
在本实施例中，白光发光模块52的光谱范围是400nm-700nm。
在本实施例中，白光发光模块52采用LED或LD灯珠。
应当理解的是，对本领域普通技术人员来说，可以根据上述说明加以改进或变换，而所有这些改进和变换都应属于本发明所附权利要求的保护范围。
Claims (9)
1.一种出光角度可调的可视化光热治疗内窥镜装置，其特征在于：包括能发射白光和红外光的荧光冷光源(5)，荧光冷光源(5)的出射光线经导光光缆(4)导入荧光内窥镜(2)中的光纤并从荧光内窥镜(2)头端出射，荧光内窥镜(2)能接收反射的白光及激发的荧光，荧光内窥镜(2)的接收光线经光学适配器(3)和荧光摄像系统主机(6)成像后由显示器(7)显示图像，光学适配器(3)采用双光路分别接收白光图像和荧光图像从而能在成像后分别显示；荧光冷光源(5)包括白光发光模块(52)和红外发光模块(54)，白光发光模块(52)和红外发光模块(54)发射的光线先经过各自的准直透镜组(53、55)调整发散角度，再经过合光镜片(57)合光沿同一方向出射，最后经聚光透镜组(58)汇聚至导光光缆(4)，位移控制模块(56)控制红外光准直透镜组(55)垂直于红外发光模块(54)光轴向移动。
2.如权利要求1所述的出光角度可调的可视化光热治疗内窥镜装置，其特征在于：红外发光模块(54)的光谱范围是1000nm-1700nm。
3.如权利要求1所述的出光角度可调的可视化光热治疗内窥镜装置，其特征在于：位移控制模块(56)控制红外光准直透镜组(55)垂直于红外发光模块(54)光轴向移动时，当红外光准直透镜组(55)位于红外光路中时，红外光线角度集中在±10°之间，当红外光准直透镜组(55)离开红外光路时，红外光线角度集中在±40°之间。
4.如权利要求1所述的出光角度可调的可视化光热治疗内窥镜装置，其特征在于：荧光冷光源(5)能选择单独输出白光、单独输出红外光、同时输出白光和红外光。
5.如权利要求1所述的出光角度可调的可视化光热治疗内窥镜装置，其特征在于：白光发光模块(52)和红外发光模块(54)上分别配有散热器(51)。
6.如权利要求1所述的出光角度可调的可视化光热治疗内窥镜装置，其特征在于：合光镜片(57)镀有合光膜，能透射白光、反射红外光。
7.如权利要求1所述的出光角度可调的可视化光热治疗内窥镜装置，其特征在于：荧光图像以伪色彩图的形式显示。
8.如权利要求1所述的出光角度可调的可视化光热治疗内窥镜装置，其特征在于：白光发光模块(52)的光谱范围是400nm-700nm。
9.如权利要求1所述的出光角度可调的可视化光热治疗内窥镜装置，其特征在于：白光发光模块(52)采用LED或LD灯珠。
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