CN116115502A

CN116115502A - Cosmetic compound containing stable liquid crystal structure and preparation method thereof

Info

Publication number: CN116115502A
Application number: CN202310265002.2A
Authority: CN
Inventors: 李泽巧; 张宝江
Original assignee: Luenzeya Group Co ltd
Current assignee: Luenzeya Group Co ltd
Priority date: 2023-03-18
Filing date: 2023-03-18
Publication date: 2023-05-16
Anticipated expiration: 2043-03-18
Also published as: CN116115502B

Abstract

The application relates to the technical field of liquid crystal cosmetics, and particularly discloses a cosmetic compound containing a stable liquid crystal structure. A cosmetic composition containing stable liquid crystal structure comprises phase A, phase B and phase C; the phase A comprises the following components: thickener, glycerol, sodium hyaluronate, xanthan gum, dipotassium glycyrrhizinate and ultrapure water; the phase B comprises the following components: emulsifying agent, cetostearyl alcohol, vegetable oil, dioctyl carbonate, isostearate, polydimethylsiloxane, phytosterol oleate, tocopherol, and auxiliary emulsifying agent; the phase C comprises the following components: carrier, choline, nanoparticles. The cosmetic compound containing the stable liquid crystal structure has the advantages of high stability of the liquid crystal structure and long residence time on the surface of the skin.

Description

Cosmetic compound containing stable liquid crystal structure and preparation method thereof

Technical Field

The present application relates to the technical field of cosmetics, and more particularly, to a cosmetic composition containing a stable liquid crystal structure and a preparation method thereof.

Background

Liquid crystals are a state of matter between crystals and liquid, which has both fluidity of liquid and regularity of arrangement of solid molecules. The types of liquid crystals currently used in cosmetics include thermosensitive liquid crystals and lyotropic liquid crystals, and the thermosensitive liquid crystals are mainly used for preparing color paste liquid crystals with warm color effect. Lyotropic liquid crystals are mainly used for preparing skin care cosmetics, and generally consist of a compound solute and a corresponding solvent, and the formation of liquid crystal phases is caused by the solubility change of the compound solute in the solvent.

The liquid crystal cosmetics are high-end cosmetics which are popular in recent years, and because the liquid crystal molecular structure and arrangement characteristics are similar to those of skin, the molecules forming human cells are mostly liquid crystal molecules or liquid crystal-like molecules, so that the liquid crystal cosmetics have good adaptability to human tissues, good permeability and wettability to skin, comfortable skin feel, safety and reliability.

The Chinese patent application document with the application publication number of CN1072333218A discloses a lamellar liquid crystal moisturizing cream and a preparation method thereof, wherein the lamellar liquid crystal moisturizing cream comprises the following components, liquid crystal emulsifier, 3-5%; butter of Butyrospermum parkii, 10-30%; 10-20% of hydrogenated vegetable oil; emulsifying auxiliary additive 1-2%; 1-3% of phytosterol isostearate; 1-5% of polydimethylsiloxane; ethylhexyl palmitate, 5-10%; xylitol, 0.5-2%; EDTA disodium, 0.01-0.1%; oil phase adhesion promoter, 0.1-3%; p-hydroxyacetophenone, 0.1-3%;1, 2-hexanediol, 0.1-3%; essence, 0.01-0.1%; deionized water is added to 100 percent. The skin barrier is increased through the double-layer structure of the multi-layer gel ester, and the moisturizing effect is better.

Another example is chinese patent application document with application publication number CN110101629a, which discloses a liquid crystal type cream composition and a preparation method thereof, which is prepared from the following components: sucrose monostearate & cetyl palmitate, sodium stearyl glutamate, synthetic squalane, jojoba oil, triglyceride, octyl polymethylsiloxane, cetyl polydimethylsiloxane, glycerol, 1, 3-butanediol, sodium hyaluronate, ammonium acryloyldimethyl taurate/VP copolymer, silicon-treated titanium dioxide, cinnamon bark extract, disodium ethylenediamine tetraacetate, p-hydroxyacetophenone, 1, 2-hexanediol and lily water, and has good moisturizing and oil controlling effects.

For the liquid crystal cosmetic, the liquid crystal structure in the emulsion has higher temperature sensitivity, so that the liquid crystal structure cannot stay for a long time near the skin temperature, and the stability of the liquid crystal structure is poor.

Disclosure of Invention

In order to solve the problems that a liquid crystal structure cannot stay for a long time near the skin temperature and is poor in stability, the application provides a cosmetic compound containing a stable liquid crystal structure and a preparation method of the cosmetic compound.

In a first aspect, the present application provides a cosmetic composition comprising a stable liquid crystal structure, according to the following technical scheme:

a cosmetic composition containing stable liquid crystal structure comprises phase A, phase B and phase C;

based on the total weight of the compound, the phase A comprises the following components in percentage by mass: 0.4-0.6% of thickener, 7-9% of glycerin, 0.04-0.06% of sodium hyaluronate, 0.08-0.12% of xanthan gum, 0.04-0.06% of dipotassium glycyrrhizinate and ultrapure water, and supplementing to 100%;

based on the total weight of the compound, the phase B comprises the following components in percentage by mass: 5-6.5% of emulsifying agent, 2.5-3.5% of cetostearyl alcohol, 7-9% of vegetable oil, 1.5-2.5% of dioctyl carbonate, 1.5-2.5% of isostearyl alcohol isostearate, 2-4% of polydimethylsiloxane, 0.4-0.55% of phytosterol oleate, 0.08-0.15% of tocopherol and 1-2% of auxiliary emulsifying agent;

based on the total weight of the compound, the C phase comprises the following components in percentage by mass: 1 to 1.5 percent of carrier, 0.065 to 0.08 percent of choline and 0.3 to 0.5 percent of nano particles;

the carrier is prepared by a method comprising the following steps:

1) Dissolving nano cellulose in a quaternary ammonium alkali solution to prepare a dissolving solution, and then uniformly mixing urea, water and organic acid to prepare a dispersing solution;

2) Pouring the dissolution liquid into the dispersion liquid, wherein the volume ratio of the dissolution liquid to the dispersion liquid is (10-25) (80-95), and then shearing at high speed to obtain the nano-crystalline silicon dioxide.

By adopting the technical scheme, the vegetable oil component is adopted as the oil phase, so that the skin-care oil has better permeability and absorbability, strong affinity with skin and stable performance. On the other hand, the formed emulsion has complete liquid crystal structure and high and uniform liquid crystal density. After glycerol, xanthan gum, sodium hyaluronate and dipotassium glycyrrhizinate are added, the interface property of the phase A can be changed, the orderly arrangement of the emulsifier on the interface is promoted, and the formation of a liquid crystal structure is facilitated. In addition, after active ingredients such as cetostearyl alcohol, isostearate, polydimethylsiloxane, phytosterol oleate, tocopherol, auxiliary emulsifier and the like are added, the stability of the formula is improved, and the complete and clear liquid crystal structure is formed.

After introducing C phase into the compound system, the nano particles are uniformly dispersed in the carrier to form a plurality of anchoring sites, and the nano cellulose molecular chains in the carrier have strong hydrogen bonding and crosslinking effects, so that the carrier can form a space network structure in the emulsion by taking the anchoring sites as the center, and choline is uniformly wrapped in the space network structure, and the nano particles, choline, nano cellulose and other components in the space network structure are rearranged and assembled through the physical and chemical effects among molecules, so that the space network structure not only plays a role in stabilizing the liquid crystal system, but also limits the size of water/oil drops in a proper range, and the liquid crystal particles are smaller and more uniform.

After the skin surface is smeared, the nano particles in the space network structure can absorb and conduct heat, so that the molecular diffusion driven by temperature difference is reduced, and meanwhile, choline molecules absorb and transfer the heat in the space network structure and are converted into charge energy, so that electron delocalization is increased, and the interaction force between adjacent molecules is enhanced. At the moment, under the combined action of the nano particles and choline, the compactness of the space network structure is improved to a certain extent, the texture disintegration of the liquid crystal particles can be limited, the stability of the liquid crystal structure is greatly improved, and the liquid crystal structure can be stably and completely stored on the surface of the skin for a long time.

Preferably, the solubility of the nanocellulose in the dissolution liquid is 1.5-3%.

By adopting the technical scheme, the solubility of the nanocellulose in the dissolution liquid is optimized and adjusted, and the crosslinking state between nanocellulose molecular chains is improved, so that the sparseness and compactness degree of a space network structure are adjusted, and the stabilizing effect on a liquid crystal structure is further enhanced.

Preferably, the nanocellulose is at least one of nano bacterial cellulose, nano microcrystalline cellulose and nano cellulose acetate.

By adopting the technical scheme, the molecular size of the nano bacterial cellulose is smaller, and the anisotropy of the formed carrier space network structure is higher, so that the heat conduction performance is better, but the mechanical property is poorer. The molecular sizes of the nano microcrystalline cellulose and the nano cellulose acetate are larger, the formed carrier space network structure has better mechanical property, and the limit effect on liquid crystal particles is good, but the anisotropic heat conductivity is lower, so that the test and the screening of the type composition of the nano cellulose further improve the stabilizing effect of the space network structure on the liquid crystal structure.

Preferably, the choline is one or more of choline fluoride, choline bromide, choline chloride, choline iodide, phosphatidylcholine.

By adopting the technical scheme, the types of choline are optimized and regulated, so that the chemical stability of choline molecules in a system is improved on one hand, and the choline molecules are not easy to decompose. On the other hand, the choline fluoride, the choline bromide, the choline chloride, the choline iodide and the phosphatidylcholine molecules introduce strong electron withdrawing groups, so that the sensitivity to temperature is higher, the heat conversion efficiency is improved, and a better stabilizing effect is further achieved.

Preferably, the choline consists of (10.5-12) of fluorinated choline and (2.8-3.5) of phosphatidylcholine according to the mass ratio.

By adopting the technical scheme, the composition ratio of choline is optimized and adjusted, more choline fluoride and less phosphatidylcholine are introduced, so that the heat conversion performance and the polarization performance are balanced, the heat stability of a space network structure and the limiting effect of liquid crystal particles are further enhanced, and a more uniform and stable liquid crystal structure is obtained.

Preferably, the nanoparticle is at least one of nano silicon dioxide, nano zinc oxide, nano silver, nano titanium dioxide and nano aluminum oxide.

By adopting the technical scheme, the variety composition of the nano particles is optimized and adjusted, the heat conduction effect and the anchoring effect of the nano particles are balanced, the probability of defects of the space network structure is reduced, the interface state of the space network structure is improved, and the compatibility with an emulsion system is improved.

Preferably, the nanoparticles have an average particle size of 5-100nm.

By adopting the technical scheme, when the nano particles are used as the anchoring sites, the particle size has a larger influence on the crosslinking arrangement of the nano cellulose molecules, when the size of the nano particles is smaller, the entanglement arrangement of the molecular chains is not easy to be initiated, and the spreading effect taking the anchoring sites as the center is weaker. When the size of the nanoparticle is large, excessive entanglement of molecular chains is easily caused, resulting in the generation of defects of a network structure. Therefore, the average particle diameter of the nano particles is tested and adjusted, and the crosslinking, arrangement and distribution state of the space network structure are further improved, so that a better stabilizing effect is obtained.

Preferably, the mass ratio of the carrier to the emulsifier is (0.2-0.225): 1

By adopting the technical scheme, the mass ratio of the carrier to the emulsifier is optimized and adjusted, the interface state between the space network structure and the water/oil emulsion liquid drops is improved, so that the viscosity of the emulsion system is in a proper range, the formation of a uniform system is facilitated, and the emulsion system has good suitability.

In a second aspect, the present application provides a method for preparing a cosmetic composition containing a stable liquid crystal structure, which adopts the following technical scheme:

a method for preparing a cosmetic composition containing a stable liquid crystal structure, comprising the steps of:

s1: adding the oil phase into the water phase under the condition of continuous homogenization, and uniformly mixing;

s2: cooling under stirring.

Through adopting above-mentioned technical scheme, add the oil phase into the aqueous phase while homogeneity, then make water/fluid drop more, more even liquid crystal granule at the cooling for liquid crystal structure is more complete.

Preferably, the homogenizing process is as follows: homogenizing speed 7500-9000r/min, and homogenizing time 3-7min.

By adopting the technical scheme, the water/oil liquid drop dispersion in the emulsion system is promoted at a proper homogenization speed and a proper homogenization time, and the particle size of the generated emulsion is more uniform and smaller, so that the smaller the liquid crystal particles are, the higher the uniformity is.

In summary, the present application has the following beneficial effects:

1. the cosmetic compound with uniform liquid crystal particles and complete liquid crystal structure is obtained by adopting the phase A, the phase B and the phase C to form an emulsion system, wherein the phase C is utilized to form a stable space network structure in the emulsion system, so that the cosmetic compound can adapt to the transition from the initial temperature to the skin temperature during use, and the space network structure can timely absorb, transfer and diffuse heat from the skin when the skin surface stays for a long time, and the stability of the liquid crystal structure is maintained. And the space network structure can help to lock the moisture of the emulsion system and delay the evaporation speed of the moisture along with the time, so that the emulsion liquid crystal layer stays on the skin surface for a long time, and meanwhile, the emulsion liquid crystal layer has warm and cool skin feel and lasting moisturizing capability.

2. In the application, choline, nanocellulose and nano particles which are composed of proper types are preferably adopted to obtain better molecular arrangement and crosslinking state, so that the stabilizing effect of a space network structure is further improved.

3. The cosmetic compound containing the stable liquid crystal structure prepared by the preparation method has higher stability, and the emulsion liquid crystal structure can stay on the surface of the skin for a long time and keep complete, so that the protective effect is fully exerted.

Drawings

Fig. 1: the results of the emulsion liquid crystal structure integrity test after various residence times on the skin surface of the cosmetic compositions containing stable liquid crystal structures in examples 1-9 and comparative examples 1-6 of the present application are shown in the figures.

Fig. 2: the results of the emulsion water content test after various residence times on the skin surface of the cosmetic compositions containing stable liquid crystal structures in examples 1 to 9 and comparative examples 1 to 6 are shown in the figures.

Fig. 3: emulsion liquid crystal structure after a skin surface residence time of 2h for the cosmetic composition containing a stable liquid crystal structure of example 9 of this application.

Fig. 4: emulsion liquid crystal structure after a skin surface residence time of 6h for the cosmetic composition containing a stable liquid crystal structure of example 9 of this application.

Fig. 5: emulsion liquid crystal structure after a skin surface residence time of 8h for the cosmetic composition containing a stable liquid crystal structure of example 9 of this application.

Detailed Description

The present application is described in further detail below with reference to examples.

The raw materials of the examples and comparative examples herein are commercially available in general unless otherwise specified.

The embodiment of the application provides a cosmetic compound containing a stable liquid crystal structure, which consists of A phase, B phase and C phase; based on the total weight of the compound, the phase A comprises the following components in percentage by mass: 0.4-0.6% of thickener, 7-9% of glycerin, 0.04-0.06% of sodium hyaluronate, 0.08-0.12% of xanthan gum, 0.04-0.06% of dipotassium glycyrrhizinate and ultrapure water, and supplementing to 100%;

based on the total weight of the compound, the phase C comprises the following components in percentage by mass: 1 to 1.5 percent of carrier, 0.065 to 0.08 percent of choline and 0.3 to 0.5 percent of nano particles;

the carrier is prepared by the method comprising the following steps:

Preferably, in the phase A component, the thickener is at least one of hydroxyethyl acrylate/sodium acryloyldimethyl taurate copolymer, polysorbate-60 and sorbitan isostearate.

Preferably, in the B phase component, the emulsifier is one or more of lecithin, cetyl alcohol, glycerol stearate, PEG-75 stearate, cetyl alcohol polyether-20 and stearyl alcohol polyether-20.

Preferably, the vegetable oil is one of isooctyl palmitate, shea butter, olive oil, isopropyl myristate, caprylic/capric triglyceride, and sunflower seed oil.

Preferably, the auxiliary emulsifier is one or more of ethylene glycol, butanediol and ethanol.

Examples

Example 1

The cosmetic composition containing a stable liquid crystal structure of this example is composed of a phase a, a phase B and a phase C.

The compositions of phase a, phase B and phase C, based on the total weight of the composite, are shown in table 1:

TABLE 1 cosmetic composition Components Table containing stabilized liquid Crystal Structure of example 1

The carrier of the embodiment is prepared by the following steps:

1) Dissolving nano cellulose acetate in a quaternary ammonium alkali solution under the protection of nitrogen to prepare a solution, and uniformly mixing urea, water and organic acid according to a mass ratio of 3:30:5 to prepare a dispersion;

2) Pouring the dissolution liquid into the dispersion liquid, wherein the volume ratio of the dissolution liquid to the dispersion liquid is 10:95, and then shearing at high speed to obtain the nano-crystalline silicon dioxide.

Wherein the solubility of the nano cellulose acetate in the dissolution liquid is 5%. The quaternary ammonium base is tetrabutylammonium hydroxide. The organic acid is azelaic acid.

The preparation method of the cosmetic compound containing the stable liquid crystal structure of the embodiment is characterized by comprising the following steps:

s1: slowly adding the oil phase into the water phase under the condition of continuous homogenization, and uniformly mixing to obtain a homogenized solution, wherein the emulsification temperature is 80 ℃, the homogenization speed is 7500r/min, and the homogenization time is 7min;

s2: uniformly mixing the C phase components to prepare a premix, adding the premix into the homogeneous solution under the stirring condition of 500rpm, mixing for 30min, and cooling to 35 ℃ in the temperature environment of 26 ℃ to obtain the emulsion system.

Example 2

The compositions of phase a, phase B and phase C, based on the total weight of the composite, are shown in table 2:

TABLE 2 cosmetic composition Components Table containing stabilized liquid Crystal Structure of example 2

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The carrier of the embodiment is prepared by the following steps:

1) Dissolving nano microcrystalline cellulose in a quaternary ammonium alkali solution under the protection of nitrogen to prepare a dissolving solution, and uniformly mixing urea, water and organic acid according to a mass ratio of 5:30:6 to prepare a dispersing solution;

2) Pouring the dissolution liquid into the dispersion liquid, wherein the volume ratio of the dissolution liquid to the dispersion liquid is 25:80, and then shearing at high speed to obtain the nano-crystalline silicon dioxide.

Wherein the solubility of the nano microcrystalline cellulose in the dissolution liquid is 1.5%. The quaternary ammonium base is tetrabutylammonium hydroxide. The organic acid is citric acid.

s1: rapidly adding the oil phase into the water phase under the condition of continuous homogenization, and uniformly mixing to obtain a homogenized solution, wherein the emulsification temperature is 80 ℃, the homogenization speed is 9000r/min, and the homogenization time is 3min;

s2: uniformly mixing the C phase components to prepare a premix, adding the premix into the homogeneous solution under the stirring condition of 700rpm, mixing for 30min, and cooling to 35 ℃ in the temperature environment of 26 ℃ to obtain the emulsion system.

Example 3

TABLE 3 cosmetic composition Components Table containing stabilized liquid Crystal Structure of example 3

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The carrier of the embodiment is prepared by the following steps:

1) Dissolving nano bacterial cellulose and nano microcrystalline cellulose in a quaternary ammonium alkali solution according to a mass ratio of 8:1.5 under the protection of nitrogen to prepare a solution, and uniformly mixing urea, water and organic acid according to a mass ratio of 5:30:8 to prepare a dispersion;

2) Pouring the dissolution liquid into the dispersion liquid, wherein the volume ratio of the dissolution liquid to the dispersion liquid is 20:90, and then shearing at high speed to obtain the nano-crystalline silicon dioxide.

Wherein the total solubility of the nano bacterial cellulose and the nano microcrystalline cellulose in the dissolution liquid is 3 percent. The quaternary ammonium base is tetrabutylammonium hydroxide. The organic acid is glycolic acid.

s1: rapidly adding the oil phase into the water phase under continuous homogenization conditions, and uniformly mixing to obtain a homogenized solution, wherein the emulsification temperature is 80 ℃, the homogenization speed is 8000r/min, and the homogenization time is 5min;

s2: uniformly mixing the C phase components to prepare a premix, adding the premix into the homogeneous solution under the stirring condition of 300rpm, mixing for 30min, and cooling to 35 ℃ in the temperature environment of 26 ℃ to obtain the emulsion system.

Example 4

The cosmetic composition containing a stable liquid crystal structure of this example is different from that of example 3 in that:

the carrier of the embodiment is prepared by the following steps:

Wherein the total solubility of the nano bacterial cellulose and the nano microcrystalline cellulose in the dissolution liquid is 2 percent. The quaternary ammonium base is tetrabutyl phosphonium hydroxide. The organic acid is glycolic acid.

The preparation method of the cosmetic composition containing a stable liquid crystal structure of this example is the same as that of example 3.

Example 5

The cosmetic composition containing a stable liquid crystal structure of this example is different from that of example 4 in that:

in the C phase component of this example, choline is composed of choline bromide and choline iodide in a mass ratio of 10.5:2.8, and the rest is the same as in example 4.

The preparation method of the carrier of this example is the same as that of example 4.

The preparation method of the cosmetic composition containing a stable liquid crystal structure of this example is the same as that of example 4.

Example 6

in the C phase component of this example, choline is composed of choline fluoride and phosphatidylcholine in a mass ratio of 10.5:2.8, and the rest is the same as in example 4.

Example 7

in the C phase component of this example, choline is composed of choline fluoride and phosphatidylcholine in a mass ratio of 12:3.5, and the rest is the same as in example 4.

Example 8

in the C phase component of this example, choline is composed of choline fluoride and phosphatidylcholine in a mass ratio of 11.5:3.2, and the rest is the same as in example 4.

Example 9

The cosmetic composition containing a stable liquid crystal structure of this example is different from that of example 8 in that:

in the C phase component of this example, the nanoparticles consisted of nanosilicon dioxide and nanosilicon dioxide in a mass ratio of 3:1.2, the remainder being the same as in example 8.

The nanoparticle of this embodiment is modified, comprising the steps of:

a) 1mol of hexylthiophene, 0.05mol of silane coupling agent, 100ml of dimethylbenzene and 150g of nano particles are added into a four-neck flask and mixed for 20min to prepare a reaction base solution;

b) Heating the reaction base solution to 110 ℃, taking 1.2mol of 4-bromo-1-indenone, slowly adding the mixture into the reaction base solution under continuous stirring, heating to 160 ℃ for constant temperature reaction for 8 hours, and filtering, washing and drying the mixture to obtain the catalyst.

The preparation method of the carrier of this example was the same as that of example 8.

The preparation method of the cosmetic composition containing a stable liquid crystal structure of this example is the same as that of example 8.

Comparative example

Comparative example 1

The cosmetic compound containing a stable liquid crystal structure of this comparative example is different from that of example 3 in that: the composite consisted of phase a and phase B, with no addition of phase C, and the remainder was the same as in example 3.

The preparation method of the cosmetic compound containing the stable liquid crystal structure of the comparative example is characterized by comprising the following steps:

s2: cooling the homogeneous solution to 35 ℃ under the stirring condition of 300rpm at 26 ℃.

Comparative example 2

The cosmetic compound containing a stable liquid crystal structure of this comparative example is different from that of example 3 in that: phase C contained no support and the remainder was the same as in example 3.

The preparation method of the cosmetic compound containing a stable liquid crystal structure of this comparative example is the same as in example 3.

Comparative example 3

The cosmetic compound containing a stable liquid crystal structure of this comparative example is different from that of example 3 in that: phase C contains no nanoparticles and the remainder is the same as in example 3.

Comparative example 4

The cosmetic compound containing a stable liquid crystal structure of this comparative example is different from that of example 3 in that: phase C does not contain choline chloride, and the remainder is the same as in example 3.

Comparative example 5

The cosmetic compound containing a stable liquid crystal structure of this comparative example is different from that of example 3 in that: phase C is carbomer 980, the remainder being the same as in example 3.

Comparative example 6

The cosmetic composition containing a stable liquid crystal structure of this comparative example is different from that of example 8 in that:

in the C phase component of the comparative example, the nano particles consist of nano silicon dioxide and nano titanium dioxide according to the mass ratio of 3:1.2, and the rest is the same as in example 8.

The nano particles of the comparative example are modified and comprise the following steps:

a) Adding 0.05mol of silane coupling agent, 100ml of dimethylbenzene and 150g of nano particles into a four-neck flask, and mixing for 20min to prepare a reaction base solution;

b) Filtering out the reaction base solution, washing and drying.

The preparation method of the vector of this comparative example was the same as in example 8.

The cosmetic compound containing a stable liquid crystal structure of this comparative example was prepared in the same manner as in example 8.

Performance test

Detection method

1. Skin stability test

The cosmetic compositions of examples 1 to 9 and comparative examples 1 to 6 containing stable liquid crystal structures were taken, the liquid crystal structure ratio was observed, then the test area of the skin of the tester was rubbed with alcohol, the above-mentioned composition was smeared, then the liquid crystal structure ratio was observed under a polarizing microscope by scraping the emulsion on the skin surface of the tester at different residence times, the integrity of the liquid crystal structure after the different residence times of the emulsion was tested, and the stability of the liquid crystal structure was evaluated with the integrity, and the test results are shown in fig. 1.

2. Emulsion moisture content test

The cosmetic compositions of examples 1 to 9 and comparative examples 1 to 6 containing stable liquid crystal structures were taken, the liquid crystal structures were observed, then the test areas of the skin of the tester were rubbed with alcohol, the above-mentioned compositions were smeared, then the emulsions on the skin surface of the tester were scraped at different times, the water content of the emulsions after different times was measured by a weighing method, the water loss rate of the emulsions on the skin surface was evaluated by the water content, and the test results are shown in fig. two.

Analysis of results

As can be seen from analysis of examples 1-3 and comparative example 1 in combination with fig. 1 and fig. two, the application adopts a combination of phase a, phase B and phase C, the carrier in the phase C can form a space network structure in the emulsion system, can generate a viscous limiting effect on liquid crystal particles, after the liquid crystal particles are coated on the surface of skin, heat of the skin is transferred into the emulsion system, so that the degree of thermal motion of molecules in the emulsion is increased, at the moment, the nano particles serve as anchoring sites in the space network structure, on one hand, can enhance the limiting effect of the space network structure, on the other hand, can transfer and disperse heat, and meanwhile, the choline molecules dispersed in the space network structure convert heat, so that the stability of the liquid crystal structure is greatly improved, the compound of example 3 can stay on the surface of the skin for a long time, the compound can still keep about 40% of the integrity of the liquid crystal structure after the compound is coated on the surface of the skin for 8 hours, and the compound has higher skin stability, and is beneficial to playing the relevant functions of the emulsion.

In addition, as the thermal movement degree of molecules in the emulsion system is increased, the dissipation speed of water molecules is increased, the loss speed of water molecules can be well delayed by the space network structure, choline molecules have strong water molecule binding force, the evaporation of water molecules can be offset to a certain extent, the binding effect of the liquid crystal structure on water is kept, the water content of the compound of the embodiment 3 after being smeared for 6 hours is still about 50%, the higher water content is maintained, and the moisturizing and protecting effects on skin are good. Further analysis of examples 1-9 and comparative examples 1-6 shows that the early water loss rate of the emulsion is basically not changed, but the water loss rate is obviously different with the lapse of time, and the water loss rate of the C phase component can be obviously reduced, so that a longer-time moisturizing effect is obtained.

As can be seen from the further analysis of example 3 and comparative examples 2 to 5 in combination with fig. 1 and fig. two, in comparative example 2, the stability of the liquid crystal structure in the emulsion system is drastically reduced, the texture of the liquid crystal starts to be blurred, and the choline molecules may instead cause the stability of the liquid crystal structure in the emulsion system to be reduced due to the binding effect of the space network structure formed by the carrier. In comparative example 3, no nanoparticle is added, and because of the lack of the anchoring site, the crosslinking and arrangement structure of the nanocellulose molecular chain is not perfect enough, resulting in poor "viscosity" performance of the space network structure, poor binding effect on the liquid crystal particles in the emulsion system, and large inconsistent degree of thermal movement of the space network structure close to the skin and far away from the skin without assistance of heat transfer and dispersion effect of the nanoparticle, easy occurrence of instability and decline of stabilization effect. In comparative example 4, choline chloride was not added, and it can be seen that the stabilizing effect on the liquid crystal structure was better in a short time, but the stabilizing effect was gradually decreased with the lapse of time, which was due to the lack of transformation effect, resulting in the occurrence of "punctiform" thermal imbalance inside the spatial network structure. In comparative example 5, carbomer 980 is used as a stabilizing component, so that the viscosity of an emulsion system can be increased to a certain extent, a gel crosslinking system is formed in the emulsion system, but the stabilizing effect of the crosslinking system on a liquid crystal structure is weak, the integrity of the liquid crystal structure begins to be reduced in a short time, and the residence time on the surface of skin is short.

In the comprehensive view, the nano particles, choline and the carrier in the C phase component play a very good role in compounding, can maintain a relatively complete liquid crystal structure for a longer time, and also maintain a relatively low water content.

Analysis of examples 4 and 5-8, and combination of figures one and two, shows that the composition and preparation process of the carrier are optimized and adjusted, and the composition ratio of choline is tested and screened, so that the stabilization of the space network structure is further improved, the residence time of the liquid crystal structure on the skin surface is prolonged, and the lower water content is maintained.

As can be seen from analysis examples 8, 9 and 6 and combining fig. one and fig. two, after the nanoparticles are modified, hexylthiophene is grafted and adsorbed on the surfaces of the nanoparticles under the action of a silane coupling agent, and then the nanoparticles react with 4-bromo-1-indenone to form a branched structure, and the branched structure on the surfaces of the nanoparticles can undergo charge transfer under the action of heat and high potential of the indenone ring, so that molecular-like coordination is formed between the thiazole ring and a molecular chain of the nanocellulose, and the orientation and flexibility of the space network structure are improved, and the anisotropic heat conduction performance of the space network structure is further improved. In addition, the long carbon chain alkyl of the branched structure can form an extremely thin hydrophobic molecular layer in the space network structure to cause conformational transition, so that the space network structure can dynamically shrink and expand by taking the nano particles as the center, thereby bearing long-time heat transfer circulation and further enhancing the stabilizing effect of the space network structure on the liquid crystal structure.

As can be seen from the combination of fig. three, fig. four and fig. five, the liquid crystal structure of example 9 maintains higher integrity and better stability after different residence times.

The present embodiment is merely illustrative of the present application and is not intended to be limiting, and those skilled in the art, after having read the present specification, may make modifications to the present embodiment without creative contribution as required, but is protected by patent laws within the scope of the claims of the present application.

Claims

1. A cosmetic composite containing stable liquid crystal structure is characterized by comprising A phase, B phase and C phase;

the carrier is prepared by a method comprising the following steps:

2. A cosmetic composition comprising a stable liquid crystal structure according to claim 1, wherein the solubility of nanocellulose in the solution is 1.5-3%.

3. The cosmetic composition of claim 1, wherein the nanocellulose is at least one of a nanocrystallite cellulose, and a nanocrystallite cellulose acetate.

4. The cosmetic composition of claim 1, wherein the choline is one or more of choline fluoride, choline bromide, choline chloride, choline iodide, and phosphatidylcholine.

5. The cosmetic composition containing a stable liquid crystal structure according to claim 4, wherein the choline is composed of (10.5-12) by (2.8-3.5) of fluorinated choline and phosphatidylcholine.

6. The cosmetic composition of claim 1, wherein the nanoparticle is at least one of nanosilica, nanosilver, and nanosilver.

7. The cosmetic composition of claim 6, wherein the nanoparticles have an average particle diameter of 5-100nm.

8. A cosmetic composition comprising a stable liquid crystal structure according to claim 1, wherein the mass ratio of carrier to emulsifier is (0.2-0.225): 1.

9. A method for preparing a cosmetic composition containing a stable liquid crystal structure according to any one of claims 1 to 8, comprising the steps of:

s2: cooling under stirring.

10. The method for preparing a cosmetic composition containing a stable liquid crystal structure according to claim 9, wherein the homogenizing process is: homogenizing speed 7500-9000r/min, and homogenizing time 3-7min.