CN112190488A - Cosmetic composition containing stable liquid crystal structure and preparation method thereof - Google Patents
Cosmetic composition containing stable liquid crystal structure and preparation method thereof Download PDFInfo
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- CN112190488A CN112190488A CN202011157703.7A CN202011157703A CN112190488A CN 112190488 A CN112190488 A CN 112190488A CN 202011157703 A CN202011157703 A CN 202011157703A CN 112190488 A CN112190488 A CN 112190488A
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- liquid crystal
- crystal structure
- cosmetic
- fatty acid
- acid ester
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- 239000004973 liquid crystal related substance Substances 0.000 title claims abstract description 45
- 239000002537 cosmetic Substances 0.000 title claims abstract description 43
- 239000000203 mixture Substances 0.000 title claims description 17
- 238000002360 preparation method Methods 0.000 title abstract description 5
- 235000013311 vegetables Nutrition 0.000 claims abstract description 18
- IIZPXYDJLKNOIY-JXPKJXOSSA-N 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCC\C=C/C\C=C/C\C=C/C\C=C/CCCCC IIZPXYDJLKNOIY-JXPKJXOSSA-N 0.000 claims abstract description 17
- 239000003795 chemical substances by application Substances 0.000 claims abstract description 14
- 235000014113 dietary fatty acids Nutrition 0.000 claims abstract description 14
- 229930195729 fatty acid Natural products 0.000 claims abstract description 14
- 239000000194 fatty acid Substances 0.000 claims abstract description 14
- -1 fatty acid ester Chemical class 0.000 claims abstract description 14
- 229940067606 lecithin Drugs 0.000 claims abstract description 14
- 239000000787 lecithin Substances 0.000 claims abstract description 14
- 235000010445 lecithin Nutrition 0.000 claims abstract description 14
- 150000002191 fatty alcohols Chemical class 0.000 claims abstract description 12
- 239000011159 matrix material Substances 0.000 claims abstract description 12
- 229930182558 Sterol Natural products 0.000 claims abstract description 4
- 235000003702 sterols Nutrition 0.000 claims abstract description 4
- 239000007788 liquid Substances 0.000 claims description 7
- 239000002994 raw material Substances 0.000 claims description 5
- 238000003756 stirring Methods 0.000 claims description 5
- DNIAPMSPPWPWGF-GSVOUGTGSA-N (R)-(-)-Propylene glycol Chemical compound C[C@@H](O)CO DNIAPMSPPWPWGF-GSVOUGTGSA-N 0.000 claims description 4
- 238000000034 method Methods 0.000 claims description 4
- 239000000839 emulsion Substances 0.000 claims description 3
- 238000010438 heat treatment Methods 0.000 claims description 3
- 239000006071 cream Substances 0.000 claims description 2
- 239000012467 final product Substances 0.000 claims description 2
- 239000000499 gel Substances 0.000 claims description 2
- 235000015110 jellies Nutrition 0.000 claims description 2
- 239000008274 jelly Substances 0.000 claims description 2
- 239000006210 lotion Substances 0.000 claims description 2
- 239000002674 ointment Substances 0.000 claims description 2
- 229920006395 saturated elastomer Polymers 0.000 claims description 2
- 210000002966 serum Anatomy 0.000 claims description 2
- 239000002453 shampoo Substances 0.000 claims description 2
- 230000000475 sunscreen effect Effects 0.000 claims description 2
- 239000000516 sunscreening agent Substances 0.000 claims description 2
- 150000004670 unsaturated fatty acids Chemical class 0.000 claims description 2
- 235000021122 unsaturated fatty acids Nutrition 0.000 claims description 2
- 150000001875 compounds Chemical class 0.000 abstract description 5
- 239000003973 paint Substances 0.000 abstract 1
- 210000003491 skin Anatomy 0.000 description 9
- 150000002632 lipids Chemical class 0.000 description 6
- 239000010410 layer Substances 0.000 description 5
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 5
- 210000004027 cell Anatomy 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 210000002510 keratinocyte Anatomy 0.000 description 3
- 239000013543 active substance Substances 0.000 description 2
- 230000015572 biosynthetic process Effects 0.000 description 2
- 239000013078 crystal Substances 0.000 description 2
- 239000003995 emulsifying agent Substances 0.000 description 2
- 230000002045 lasting effect Effects 0.000 description 2
- 230000014759 maintenance of location Effects 0.000 description 2
- 210000000434 stratum corneum Anatomy 0.000 description 2
- 241000894006 Bacteria Species 0.000 description 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 1
- ODKSFYDXXFIFQN-BYPYZUCNSA-N L-arginine Chemical compound OC(=O)[C@@H](N)CCCN=C(N)N ODKSFYDXXFIFQN-BYPYZUCNSA-N 0.000 description 1
- 229930064664 L-arginine Natural products 0.000 description 1
- 235000014852 L-arginine Nutrition 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 238000003287 bathing Methods 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 210000003855 cell nucleus Anatomy 0.000 description 1
- 239000006059 cover glass Substances 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 239000008367 deionised water Substances 0.000 description 1
- 229910021641 deionized water Inorganic materials 0.000 description 1
- 230000001419 dependent effect Effects 0.000 description 1
- NOPFSRXAKWQILS-UHFFFAOYSA-N docosan-1-ol Chemical compound CCCCCCCCCCCCCCCCCCCCCCO NOPFSRXAKWQILS-UHFFFAOYSA-N 0.000 description 1
- 239000003792 electrolyte Substances 0.000 description 1
- 238000004945 emulsification Methods 0.000 description 1
- 230000008020 evaporation Effects 0.000 description 1
- 238000001704 evaporation Methods 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 238000012423 maintenance Methods 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 230000003020 moisturizing effect Effects 0.000 description 1
- 239000011664 nicotinic acid Substances 0.000 description 1
- 235000015097 nutrients Nutrition 0.000 description 1
- 229940049964 oleate Drugs 0.000 description 1
- ZQPPMHVWECSIRJ-KTKRTIGZSA-N oleic acid Chemical compound CCCCCCCC\C=C/CCCCCCCC(O)=O ZQPPMHVWECSIRJ-KTKRTIGZSA-N 0.000 description 1
- 230000003287 optical effect Effects 0.000 description 1
- 210000003463 organelle Anatomy 0.000 description 1
- 230000003647 oxidation Effects 0.000 description 1
- 238000007254 oxidation reaction Methods 0.000 description 1
- 238000004321 preservation Methods 0.000 description 1
- 239000011241 protective layer Substances 0.000 description 1
- 230000008591 skin barrier function Effects 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 239000003053 toxin Substances 0.000 description 1
- 231100000765 toxin Toxicity 0.000 description 1
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/0295—Liquid crystals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/342—Alcohols having more than seven atoms in an unbroken chain
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/55—Phosphorus compounds
- A61K8/553—Phospholipids, e.g. lecithin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/63—Steroids; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/005—Antimicrobial preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
Abstract
The invention discloses a cosmetic compound containing a stable liquid crystal structure and a preparation method thereof, belonging to the technical field of cosmetics. The paint comprises the following components in percentage by mass: 0.20-5% of vegetable lecithin, 0.20-10% of higher fatty alcohol, 0.10-8.5% of phytosterol fatty acid ester and the balance of cosmetic matrix; wherein the liquid crystal structure forming agent comprises vegetable lecithin, higher fatty alcohol and phytosterol fatty acid ester. The liquid crystal structure forming agent is composed of vegetable lecithin, higher fatty alcohol and vegetable sterol fatty acid ester, and the cosmetic matrix and the liquid crystal structure forming agent are mixed according to the formula proportion, so that a cosmetic compound containing a stable liquid crystal structure can be prepared, and the liquid crystal structure has the advantages of high forming rate, complete structure, capability of staying near the skin temperature for a long time and easiness in storage.
Description
Technical Field
The invention relates to a cosmetic compound containing a stable liquid crystal structure and a preparation method thereof, belonging to the technical field of cosmetics.
Background
The stratum corneum is the outer protective layer of the skin and mainly consists of 5-20 layers of dead flat keratinocytes without cell nuclei and organelles and intercellular lipids wrapping the keratinocytes. Research shows that the lipid between horny layer cells forms a double-layer lipid structure, is filled between the horny layer cells, can effectively prevent the loss of water, nutrient substances and electrolyte in vivo, has the effect of deep moisture preservation, and can prevent external bacteria or toxin from invading the skin. If the lamellar structure of lipid among stratum corneum cells can be simulated, the bionic skin similar to a human body can be manufactured.
The liquid crystal is in a state between liquid and crystal in structural, mechanical and optical properties, and has both liquid fluidity and regularity of solid molecular arrangement. The liquid crystal structure cosmetic compound is a novel emulsification system different from common cosmetics, and the cosmetics are ordered molecular arrangement of a liquid crystal structure formed by emulsifier molecules at an oil-water interface. The ordered lamellar liquid crystal structure is similar to the double-layer lipid structure of intercellular lipid of keratinocytes, and has better skin care effect than common cosmetics. Firstly, the lamellar liquid crystal structure contains abundant bound water, is not easy to evaporate, has a lasting moisturizing effect, and can prevent the water-soluble active substances from being separated out due to the evaporation of water. Secondly, the layered liquid crystal structure protects the encapsulated active substance from oxidation by the external environment. Therefore, the liquid crystal structure cosmetic can improve skin barrier and control slow release of active ingredients, and has excellent performances such as lasting moisture retention and the like.
The formation of cosmetics with liquid crystal structure is not only related to the type of emulsifier, but also highly dependent on the composition of the formulation and the preparation process, etc. The liquid crystal structure cosmetics on the market still have the technical defects of low liquid crystal forming rate, incomplete structure, incapability of staying near the skin temperature for a long time, difficulty in storage and the like.
Disclosure of Invention
The technical problem to be solved by the invention is as follows: a cosmetic composition containing a stable liquid crystal structure and a method for preparing the same are provided, which solve the above problems.
The technical problem to be solved by the invention is realized by adopting the following technical scheme:
a cosmetic composition containing a stable liquid crystal structure comprises the following components in percentage by mass: 0.20-5% of vegetable lecithin, 0.20-10% of higher fatty alcohol, 0.10-8.5% of phytosterol fatty acid ester and the balance of cosmetic matrix;
wherein the liquid crystal structure forming agent comprises vegetable lecithin, higher fatty alcohol and phytosterol fatty acid ester.
As a preferred example, the vegetable lecithin is hydrogenated lecithin.
As a preferred example, the higher aliphatic alcohol is a C12-22 straight chain saturated higher aliphatic alcohol.
As a preferred example, the phytosterol fatty acid ester is a C12-22 linear or unsaturated fatty acid.
As a preferred example, the cosmetic base comprises any one of a lotion, an emulsion, a cream, a serum, a jelly, a gel, an ointment, a mask, a foundation, a sunscreen, a shampoo, a cleansing, a bathing or a makeup-removing cosmetic.
A method of preparing a cosmetic composition comprising a stable liquid crystalline structure, comprising the steps of:
(1) preparing raw materials in percentage by mass: 0.20-5% of vegetable lecithin, 0.20-10% of higher fatty alcohol, 0.10-8.5% of phytosterol fatty acid ester and the balance of cosmetic matrix; wherein the liquid crystal structure forming agent consists of vegetable lecithin, higher fatty alcohol and vegetable sterol fatty acid ester;
(2) respectively stirring the liquid crystal structure forming agent and the cosmetic matrix uniformly and heating to 80 ℃;
(3) adding the liquid crystal structure forming agent into the cosmetic matrix, and uniformly stirring to obtain the final product.
The invention has the beneficial effects that: the liquid crystal structure forming agent is composed of vegetable lecithin, higher fatty alcohol and vegetable sterol fatty acid ester, and the cosmetic matrix and the liquid crystal structure forming agent are mixed according to the formula proportion, so that a cosmetic compound containing a stable liquid crystal structure can be prepared, and the liquid crystal structure has the advantages of high forming rate, complete structure, capability of staying near the skin temperature for a long time and easiness in storage.
Drawings
FIG. 1 is an image of the structure of the liquid crystal observed in example 1 after being stored at 25 ℃ for three months;
FIG. 2 is an image of the liquid crystal structure observed in example 1 after three months of storage at 35 ℃;
FIG. 3 is an image of the liquid crystal structure observed in example 1 after being stored at 45 ℃ for three months;
FIG. 4 is an image of the liquid crystal structure observed in example 1 after three months of storage at 55 ℃.
Detailed Description
In order to make the technical means, the creation characteristics, the achievement purposes and the effects of the invention easy to understand, the invention is further explained below.
Example 1
A cosmetic composition containing a stable liquid crystal structure comprises the following components in percentage by mass:
wherein, the component A is a liquid crystal structure forming agent, and the B, C, D component jointly forms the prior emulsion cosmetic matrix for skin care.
The component A comprises:
| raw materials | Mass percent |
| Hydrogenated lecithin | 3.00％ |
| C22 alcohol | 1.00％ |
| C16-18 alcohol | 0.50％ |
| Phytosterol oleate | 1.50％ |
The component B comprises:
and the component C is as follows:
and (D) component:
| raw materials | Mass percent |
| L-arginine | 0.08％ |
| Deionized water | 3.00％ |
A method for preparing a cosmetic composition comprising a stable liquid crystalline structure:
(1) preparing raw materials according to the above table;
(2) respectively stirring the component A and the component B, C, D uniformly and heating to 80 ℃;
(3) b, C, D components are added into the component A in sequence, and the mixture is stirred evenly and discharged.
An appropriate amount of the sample of example 1 was put on a slide glass, covered with a cover glass, stored at 25 ℃, 35 ℃, 45 ℃ and 55 ℃ for three months, and observed under a 400-fold lens of a polarizing microscope.
The observations shown in FIGS. 1-4: the luminous circle is a liquid crystal structure which can be well maintained after being stored for 3 months under the condition of near skin temperature (especially 25-45 ℃).
And (4) conclusion: the cosmetic composition containing stable liquid crystal structure has high liquid crystal formation rate, complete structure, long retention time near skin temperature, long crystal structure maintenance, and convenient storage.
The foregoing shows and describes the general principles and broad features of the present invention and advantages thereof. It will be understood by those skilled in the art that the present invention is not limited to the embodiments described above, and that various changes and modifications may be made without departing from the spirit and scope of the invention as defined in the appended claims. The scope of the invention is defined by the appended claims and equivalents thereof.
Claims (6)
1. A cosmetic composition containing a stable liquid crystal structure, characterized in that it comprises, in mass%: 0.20-5% of vegetable lecithin, 0.20-10% of higher fatty alcohol, 0.10-8.5% of phytosterol fatty acid ester and the balance of cosmetic matrix;
wherein the liquid crystal structure forming agent comprises vegetable lecithin, higher fatty alcohol and phytosterol fatty acid ester.
2. The cosmetic composition comprising a stabilized liquid crystalline structure according to claim 1, wherein the vegetable lecithin is hydrogenated lecithin.
3. The cosmetic composition comprising a stabilized liquid crystalline structure of claim 1, wherein the higher aliphatic alcohol is a C12-22 linear saturated higher aliphatic alcohol.
4. The cosmetic composition containing a stabilized liquid crystal structure according to claim 1, wherein the phytosterol fatty acid ester is a C12-22 linear or unsaturated fatty acid.
5. The cosmetic composition comprising a stabilized liquid crystal structure according to claim 1, wherein the cosmetic base comprises any one of a lotion, an emulsion, a cream, a serum, a jelly, a gel, an ointment, a mask, a foundation, a sunscreen, a shampoo, a face wash, a bath or makeup-removing cosmetic.
6. A method for preparing a cosmetic composition comprising a stable liquid crystalline structure, comprising the steps of:
(1) preparing raw materials in percentage by mass: 0.20-5% of vegetable lecithin, 0.20-10% of higher fatty alcohol, 0.10-8.5% of phytosterol fatty acid ester and the balance of cosmetic matrix; wherein the liquid crystal structure forming agent consists of vegetable lecithin, higher fatty alcohol and vegetable sterol fatty acid ester;
(2) respectively stirring the liquid crystal structure forming agent and the cosmetic matrix uniformly and heating to 80 ℃;
(3) adding the liquid crystal structure forming agent into the cosmetic matrix, and uniformly stirring to obtain the final product.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202011157703.7A CN112190488A (en) | 2020-10-26 | 2020-10-26 | Cosmetic composition containing stable liquid crystal structure and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202011157703.7A CN112190488A (en) | 2020-10-26 | 2020-10-26 | Cosmetic composition containing stable liquid crystal structure and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN112190488A true CN112190488A (en) | 2021-01-08 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202011157703.7A Pending CN112190488A (en) | 2020-10-26 | 2020-10-26 | Cosmetic composition containing stable liquid crystal structure and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN112190488A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN116115502A (en) * | 2023-03-18 | 2023-05-16 | 律恩泽雅集团有限公司 | Cosmetic compound containing stable liquid crystal structure and preparation method thereof |
-
2020
- 2020-10-26 CN CN202011157703.7A patent/CN112190488A/en active Pending
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN116115502A (en) * | 2023-03-18 | 2023-05-16 | 律恩泽雅集团有限公司 | Cosmetic compound containing stable liquid crystal structure and preparation method thereof |
| CN116115502B (en) * | 2023-03-18 | 2023-08-22 | 律恩泽雅集团有限公司 | Cosmetic compound containing stable liquid crystal structure and preparation method thereof |
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