CN116113702A - 一种融合蛋白及其用途 - Google Patents
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Abstract
本申请涉及一种融合蛋白及其应用。所述融合蛋白包含RdCVF和信号肽,其中所述信号肽为SEQ ID NO:27‑31,SEQ ID NO:33中任一项所示的氨基酸序列。本申请还涉及分离的核酸分子,其包含a)编码RdCVF的多核苷酸以及b)编码信号肽的多核苷酸。本申请还提供了包含该核酸分子的载体、细胞和药物组合物等,并提供了它们的制药用途。本申请所述的融合蛋白和/或分离的核酸分子可以有效地提高RdCVF的分泌量。
Description
PCT国内申请,说明书已公开。
Claims (93)
- PCT国内申请,权利要求书已公开。
Applications Claiming Priority (3)
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CN2020107904962 | 2020-08-07 | ||
CN202010790496.2A CN111733174B (zh) | 2020-08-07 | 2020-08-07 | 一种分离的核酸分子及其用途 |
PCT/CN2021/072743 WO2022027933A1 (zh) | 2020-08-07 | 2021-01-19 | 一种融合蛋白及其用途 |
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CN111733174B (zh) * | 2020-08-07 | 2021-02-09 | 北京大学第三医院(北京大学第三临床医学院) | 一种分离的核酸分子及其用途 |
CN113015804B (zh) * | 2020-10-13 | 2022-05-17 | 北京中因科技有限公司 | 用于治疗结晶样视网膜变性的核酸分子及其用途 |
JP2024524707A (ja) * | 2021-07-15 | 2024-07-05 | シャンハイ ヴァイタルゲン バイオファーマ カンパニー リミテッド | ビエッティ結晶性ジストロフィー治療のための遺伝子組換アデノ随伴ウイルスベクター |
CN114875010B (zh) * | 2022-04-21 | 2023-10-24 | 深圳大学 | 一种提升蛋白翻译效率的基因及其编码产物与应用 |
US20240018541A1 (en) * | 2022-07-13 | 2024-01-18 | Chigenovo Co., Ltd | Vector and method for treating bietti's crystalline dystrophy |
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FR2823221B1 (fr) * | 2001-04-06 | 2004-04-02 | Univ Pasteur | Sequences associees a la degenerescence retinienne et applications |
US9265814B2 (en) * | 2005-12-30 | 2016-02-23 | Neurotech Usa, Inc. | Micronized device for the delivery of biologically active molecules and methods of use thereof |
MX354516B (es) * | 2011-10-27 | 2018-03-08 | Wellstat Ophthalmics Corp | Vectores que codifican el factor de viabilidad de conos derivado de bastones. |
AR097648A1 (es) | 2013-09-13 | 2016-04-06 | Amgen Inc | Combinación de factores epigenéticos y compuestos biespecíficos que tienen como diana cd33 y cd3 en el tratamiento de leucemia mieloide |
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WO2017120294A1 (en) * | 2016-01-05 | 2017-07-13 | The Trustees Of The University Of Pennsylvania | Methods and compositions for treatment of ocular disorders and blinding diseases |
CN116333057A (zh) * | 2016-05-13 | 2023-06-27 | 4D分子治疗有限公司 | 腺相关病毒变体衣壳和其使用方法 |
KR20230156440A (ko) * | 2016-10-11 | 2023-11-14 | 웰스테이트 옵탈믹스 코퍼레이션 | 짧은 형태의 간상체 유래 원추체 생존능 인자와 친수성 펩타이드 사이의 융합 단백질 |
WO2018100054A1 (en) * | 2016-12-01 | 2018-06-07 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Pharmaceutical compositions for the treatment of retinal degenerative diseases |
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CN109136266B (zh) * | 2018-08-10 | 2022-02-18 | 深圳泓熙生物科技发展有限公司 | 用于治疗或预防结晶样视网膜色素变性的基因载体及其用途 |
CN111733174B (zh) * | 2020-08-07 | 2021-02-09 | 北京大学第三医院(北京大学第三临床医学院) | 一种分离的核酸分子及其用途 |
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