CN116096753A - 对abcb5具有特异性的抗体及其用途 - Google Patents
对abcb5具有特异性的抗体及其用途 Download PDFInfo
- Publication number
- CN116096753A CN116096753A CN202180046044.6A CN202180046044A CN116096753A CN 116096753 A CN116096753 A CN 116096753A CN 202180046044 A CN202180046044 A CN 202180046044A CN 116096753 A CN116096753 A CN 116096753A
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- Prior art keywords
- antibody
- abcb5
- cells
- seq
- antibodies
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
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- A—HUMAN NECESSITIES
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- A61P35/00—Antineoplastic agents
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- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
- A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
- A61K47/68031—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug being an auristatin
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- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
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- A61K47/6865—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a determinant of a tumour cell the tumour determinant being from skin, nerves or brain cancer cell
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- C—CHEMISTRY; METALLURGY
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- C07K16/30—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
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- C07—ORGANIC CHEMISTRY
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- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
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- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
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- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
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- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
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- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
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- C07K2319/00—Fusion polypeptide
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- Chemical & Material Sciences (AREA)
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- Immunology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
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- Hematology (AREA)
- Urology & Nephrology (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biotechnology (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
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- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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- Pathology (AREA)
- General Physics & Mathematics (AREA)
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202063018440P | 2020-04-30 | 2020-04-30 | |
| US63/018,440 | 2020-04-30 | ||
| PCT/US2021/030342 WO2021222861A1 (en) | 2020-04-30 | 2021-04-30 | Antibodies specific to abcb5 and uses thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN116096753A true CN116096753A (zh) | 2023-05-09 |
Family
ID=78373989
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202180046044.6A Pending CN116096753A (zh) | 2020-04-30 | 2021-04-30 | 对abcb5具有特异性的抗体及其用途 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US20230203153A1 (https=) |
| EP (1) | EP4142793A4 (https=) |
| JP (1) | JP2023524102A (https=) |
| KR (1) | KR20230034944A (https=) |
| CN (1) | CN116096753A (https=) |
| AU (1) | AU2021262864A1 (https=) |
| CA (1) | CA3181591A1 (https=) |
| WO (1) | WO2021222861A1 (https=) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2019210109A1 (en) | 2018-04-25 | 2019-10-31 | Children's Medical Center Corporation | Abcb5 ligands and substrates |
| WO2020232247A1 (en) | 2019-05-14 | 2020-11-19 | Provention Bio, Inc. | Methods and compositions for preventing type 1 diabetes |
| AU2020361622A1 (en) * | 2019-10-10 | 2022-04-28 | Arizona Board Of Regents On Behalf Of Arizona State University | Oncolytic viruses that express multi-specific immune cell engagers |
| IL298999A (en) | 2020-06-11 | 2023-02-01 | Provention Bio Inc | Methods and compositions for the prevention of type 1 diabetes |
| IL308258A (en) | 2021-05-05 | 2024-01-01 | Immatics Biotechnologies Gmbh | Bma031 antigen binding polypeptides |
| JP2024520444A (ja) | 2021-05-24 | 2024-05-24 | プロヴェンション・バイオ・インコーポレイテッド | 1型糖尿病を治療するための方法 |
| WO2025004683A1 (ja) * | 2023-06-30 | 2025-01-02 | 国立大学法人大阪大学 | がん検査方法及びがん治療剤 |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2001094400A2 (en) * | 2000-06-05 | 2001-12-13 | The Brigham And Women's Hospital, Inc. | A GENE ENCODING A MULTIDRUG RESISTANCE HUMAN P-GLYCOPROTEIN HOMOLOGUE ON CHROMOSOME 7p15-21 AND USES THEREOF |
| WO2008127656A1 (en) * | 2007-04-12 | 2008-10-23 | The Brigham And Women's Hospital, Inc. | Targeting abcb5 for cancer therapy |
| WO2010065711A1 (en) * | 2008-12-04 | 2010-06-10 | Adimab, Inc. | An abcb5 epitope and antibodies thereto for the treatment of cancer |
| WO2016179576A1 (en) * | 2015-05-07 | 2016-11-10 | Bioxcel Corporation | Novel immunomodulatory therapeutic strategies targeting tumors in cancer |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114245741A (zh) * | 2019-03-28 | 2022-03-25 | 儿童医学中心公司 | 高功能性的制造的abcb5+间充质干细胞 |
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2021
- 2021-04-30 AU AU2021262864A patent/AU2021262864A1/en active Pending
- 2021-04-30 CA CA3181591A patent/CA3181591A1/en active Pending
- 2021-04-30 CN CN202180046044.6A patent/CN116096753A/zh active Pending
- 2021-04-30 KR KR1020227042053A patent/KR20230034944A/ko active Pending
- 2021-04-30 WO PCT/US2021/030342 patent/WO2021222861A1/en not_active Ceased
- 2021-04-30 US US17/922,286 patent/US20230203153A1/en active Pending
- 2021-04-30 JP JP2022566628A patent/JP2023524102A/ja active Pending
- 2021-04-30 EP EP21796792.6A patent/EP4142793A4/en active Pending
Patent Citations (4)
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| WO2001094400A2 (en) * | 2000-06-05 | 2001-12-13 | The Brigham And Women's Hospital, Inc. | A GENE ENCODING A MULTIDRUG RESISTANCE HUMAN P-GLYCOPROTEIN HOMOLOGUE ON CHROMOSOME 7p15-21 AND USES THEREOF |
| WO2008127656A1 (en) * | 2007-04-12 | 2008-10-23 | The Brigham And Women's Hospital, Inc. | Targeting abcb5 for cancer therapy |
| WO2010065711A1 (en) * | 2008-12-04 | 2010-06-10 | Adimab, Inc. | An abcb5 epitope and antibodies thereto for the treatment of cancer |
| WO2016179576A1 (en) * | 2015-05-07 | 2016-11-10 | Bioxcel Corporation | Novel immunomodulatory therapeutic strategies targeting tumors in cancer |
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| NATASHA Y. FRANK等: "Regulation of Progenitor Cell Fusion by ABCB5 P-glycoprotein, a Novel Human ATP-binding Cassette Transporter", J BIOL CHEM, vol. 278, no. 47, 21 November 2003 (2003-11-21), pages 47156 * |
| Y GAO等: "Efficient inhibition of multidrug-resistant human tumors with a recombinant bispecific anti-P-glycoprotein x anti-CD3 diabody", LEUKEMIA, vol. 18, no. 3, 31 March 2004 (2004-03-31), pages 513 * |
Also Published As
| Publication number | Publication date |
|---|---|
| WO2021222861A1 (en) | 2021-11-04 |
| JP2023524102A (ja) | 2023-06-08 |
| CA3181591A1 (en) | 2021-11-04 |
| US20230203153A1 (en) | 2023-06-29 |
| EP4142793A4 (en) | 2024-08-28 |
| AU2021262864A1 (en) | 2022-11-17 |
| EP4142793A1 (en) | 2023-03-08 |
| KR20230034944A (ko) | 2023-03-10 |
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