CN116077617A - Anti-alcohol liver-protecting granule and preparation method thereof - Google Patents

Anti-alcohol liver-protecting granule and preparation method thereof Download PDF

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Publication number
CN116077617A
CN116077617A CN202211306463.1A CN202211306463A CN116077617A CN 116077617 A CN116077617 A CN 116077617A CN 202211306463 A CN202211306463 A CN 202211306463A CN 116077617 A CN116077617 A CN 116077617A
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parts
extract powder
dry extract
extraction
liver
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Inventor
王禹璇
张博雅
江文艳
宋清娥
齐学艳
王辉
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Inner Mongolia Pu Kang Pharmaceutical Co ltd
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Inner Mongolia Pu Kang Pharmaceutical Co ltd
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    • A—HUMAN NECESSITIES
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    • A61K36/72—Rhamnaceae (Buckthorn family), e.g. buckthorn, chewstick or umbrella-tree
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    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
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    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
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Abstract

The invention discloses an anti-alcohol liver-protecting granule and a preparation method thereof, wherein the anti-alcohol liver-protecting granule is prepared from the following raw materials in parts by weight: 8 to 12 parts of semen hoveniae, 8 to 12 parts of kudzuvine root, 2.4 to 3.6 parts of virgate wormwood herb, 2.4 to 3.6 parts of rhizoma corydalis, 1.6 to 2.4 parts of chrysanthemum, 4 to 6 parts of liquorice, 2.4 to 3.6 parts of jujube, 1.6 to 2.4 parts of schisandra chinensis, 4.8 to 7.2 parts of galangal, 4 to 6 parts of corn oligopeptide, 1.6 to 2.4 parts of honey, 0.8 to 1.2 parts of taurine, 0.4 to 0.6 part of L-cysteine, 0.24 to 0.36 part of inosine, 0.04 to 0.06 part of vitamin C, 0.08 to 0.12 part of vitamin B complex and a proper amount of auxiliary materials. The anti-hangover and liver-protecting granule is prepared by extracting Chinese medicinal materials with water, and granulating with other materials by dry method. It has effects of rapidly relieving hangover, relieving discomfort after drinking, and protecting alcoholic liver injury.

Description

Anti-alcohol liver-protecting granule and preparation method thereof
Technical Field
The invention belongs to the technical field of health-care food and manufacturing thereof, and particularly relates to anti-alcohol liver-protecting particles and a preparation method thereof.
Background
The drinking becomes a living habit of people and is an indispensable social way, every festival, joss, celebration, birthday, wedding and the like can not be helped by using the wine, and alcoholism is one of the current world number nuisances.
At present, a large number of anti-alcohol medicines are emerging in the market, and Chinese patent CN1238036C discloses a pure natural anti-alcohol liver-protecting granule which is prepared from the following raw medicines in parts by weight: 4-6 parts of kudzuvine root, 8-12 parts of hovenia dulcis thunb, 2-3 parts of dried orange peel, 5-7 parts of hawthorn, 3-5 parts of corn silk and 4-6 parts of poria cocos. Chinese patent CN 104971150A discloses a golden camellia granule for dispelling effects of alcohol and protecting liver and a preparation process thereof, wherein the golden camellia granule is prepared from the following raw materials in parts by weight: 20-40 parts of golden camellia leaves, 10-20 parts of shizandra berry, 20-40 parts of red sage root, 10-20 parts of hericium erinaceus, 10-20 parts of virgate wormwood herb and 5-15 parts of liquorice.
The anti-alcohol medicinal granules in the prior art are mostly compounded by a plurality of plant extracts, are prepared according to the theory of traditional Chinese medicine, are complementary in all herb water extraction medicines, multiple in taste and multiple in elements, treat both principal and secondary aspect of disease, and are proved to be the main proved recipe. However, the proved formulas are difficult to explore and clear the names, components, quantity of effective elements in plants and the drug property relationship of intermodulation complementation among the elements; in recent years, the modern pharmacy has successfully developed a plurality of biochemical drugs with single active ingredients, and also has a plurality of biochemical drugs with definite treatment and health care effects and single active ingredients in the aspects of dispelling effects of alcohol and protecting liver. According to the principle of combining Chinese and western medicines, the invention provides the anti-alcohol liver-protecting granule which has separate treatment and synergistic anti-alcohol liver-protecting effect.
Disclosure of Invention
The invention aims to provide the anti-alcohol liver-protecting granule which not only has the effects of dispelling the effects of alcohol and relieving the discomfort of the body after drinking, but also has the protection effect on alcoholic liver injury.
The invention also provides a preparation method of the anti-alcohol liver-protecting granule.
The first aim of the invention is to provide an anti-alcohol liver-protecting granule which is prepared from the following raw materials in parts by weight: 8 to 12 parts of semen hoveniae, 8 to 12 parts of kudzuvine root, 2.4 to 3.6 parts of virgate wormwood herb, 2.4 to 3.6 parts of rhizoma corydalis, 1.6 to 2.4 parts of chrysanthemum, 4 to 6 parts of liquorice, 2.4 to 3.6 parts of jujube, 1.6 to 2.4 parts of schisandra chinensis, 4.8 to 7.2 parts of galangal, 4 to 6 parts of corn oligopeptide, 1.6 to 2.4 parts of honey, 0.8 to 1.2 parts of taurine, 0.4 to 0.6 part of L-cysteine, 0.24 to 0.36 part of inosine, 0.04 to 0.06 part of vitamin C, 0.08 to 0.12 part of vitamin B complex and a proper amount of auxiliary materials.
The optimized scheme of the anti-alcohol liver-protecting granule is prepared from the following raw materials in parts by weight: 9 to 11 parts of semen hoveniae, 9 to 11 parts of kudzuvine root, 2.7 to 3.3 parts of virgate wormwood herb, 2.7 to 3.3 parts of rhizoma corydalis, 1.8 to 2.2 parts of chrysanthemum, 4.5 to 5.5 parts of liquorice, 2.7 to 3.3 parts of jujube, 1.8 to 2.2 parts of schisandra chinensis, 5.4 to 6.6 parts of galangal, 4.5 to 5.5 parts of corn oligopeptide, 1.8 to 2.2 parts of honey, 0.9 to 1.1 part of taurine, 0.45 to 0.55 part of L-cysteine, 0.27 to 0.33 part of inosine, 0.045 to 0.055 part of vitamin C, 0.09 to 0.11 part of compound vitamin B and a proper amount of auxiliary materials.
The best scheme of the anti-alcohol liver-protecting granule is as follows: the material is prepared from the following raw materials in parts by weight: 10 parts of semen hoveniae, 10 parts of kudzuvine root, 3 parts of virgate wormwood herb, 3 parts of rhizoma corydalis, 2 parts of chrysanthemum, 5 parts of liquorice, 3 parts of Chinese date, 2 parts of shizandra berry, 6 parts of galangal, 5 parts of corn oligopeptide, 2 parts of honey, 1 part of taurine, 0.5 part of L-cysteine, 0.3 part of inosine, 0.05 part of vitamin C, 0.1 part of vitamin B complex and a proper amount of auxiliary materials.
Preferably, the auxiliary material is one or more of soluble starch, sucrose powder, dextrin, lactose and maltodextrin; more preferably, the auxiliary material is maltodextrin.
The second object of the invention is to provide a preparation method of the anti-alcohol liver-protecting granule, which can be realized by adopting the following three schemes.
The first scheme is as follows: a preparation method of anti-alcohol liver-protecting particles comprises the following steps:
1) Extracting traditional Chinese medicine: respectively extracting semen Hoveniae, radix Puerariae, herba Artemisiae Scopariae, rhizoma corydalis, flos Chrysanthemi, glycyrrhrizae radix, fructus Jujubae, fructus Schisandrae chinensis and rhizoma Alpiniae Officinarum with water, filtering, concentrating under reduced pressure to obtain fluid extract with relative density of 1.01-1.20 g/cm, adding adjuvant, and spray drying to obtain semen Hoveniae dry extract powder, radix Puerariae dry extract powder, herba Artemisiae Scopariae dry extract powder, rhizoma Hu Suogan extract powder, flos Chrysanthemi dry extract powder, glycyrrhrizae radix dry extract powder, fructus Jujubae dry extract powder, fructus Schisandrae chinensis dry extract powder and rhizoma Alpiniae Officinarum dry extract powder.
2) Mixing and granulating: adding semen Hoveniae dry extract powder, radix Puerariae dry extract powder, herba Artemisiae Scopariae dry extract powder, rhizoma Hu Suogan extract powder, flos Chrysanthemi dry extract powder, glycyrrhrizae radix dry extract powder, fructus Jujubae dry extract powder, fructus Schisandrae chinensis dry extract powder, rhizoma Alpiniae Officinarum dry extract powder, semen Maydis oligopeptide, mel, taurine, L-cysteine, inosine, vitamin C, and vitamin B complex into a stirring container, stirring, and dry granulating to obtain anti-hangover and liver protecting granule.
The second scheme is as follows: a preparation method of anti-alcohol liver-protecting particles comprises the following steps:
1) Extracting traditional Chinese medicine: mixing semen Hoveniae, radix puerariae, herba artemisiae capillaries, rhizoma corydalis, chrysanthemum, liquorice, chinese date, schisandra chinensis and galangal Chinese herbal pieces according to the raw material proportion, extracting with water, filtering, concentrating under reduced pressure to obtain fluid extract with the relative density of 1.01-1.20 g/cm, adding a proper amount of auxiliary materials into the fluid extract, and spray drying to obtain mixed Chinese herbal dry extract powder.
2) Mixing and granulating: mixing the dry extract powder of the traditional Chinese medicine, the corn oligopeptide, the honey, the taurine, the L-cysteine, the inosine, the vitamin C and the vitamin B complex according to the proportion of the raw materials, adding the mixture into a stirring container, stirring uniformly, and granulating by a dry method to obtain the anti-alcohol liver-protecting granule.
Preferably, in the steps of extracting the traditional Chinese medicine in the first scheme and the second scheme, the steps comprise the following steps:
a. adding purified water which is 6-15 times of the quality of the traditional Chinese medicine decoction pieces into the traditional Chinese medicine decoction pieces, heating for extraction, filtering, and separating filter residues to obtain primary extraction filtrate and primary extraction residues;
b. adding purified water with the mass 5-8 times of that of the first extraction residue into the first extraction residue, heating for extraction, filtering, and separating the residue to obtain second extraction filtrate and second extraction residue;
c. carrying out ultra-high temperature instantaneous sterilization on the first extraction filtrate and the second extraction filtrate, and concentrating the filtrate under reduced pressure at 50-70 ℃ to obtain clear paste with the relative density of 1.01-1.20 g/cm;
d. adding appropriate amount of adjuvant into the fluid extract, dissolving, and spray drying to obtain dry extract powder.
Third scheme: the step of extracting the traditional Chinese medicine is omitted, and the traditional Chinese medicine raw materials are directly mixed with the formula granules of the traditional Chinese medicines and the rest raw materials for granulation; the dosage proportion of the formula particles of each traditional Chinese medicine is calculated according to the proportion of the formula particles prepared by each traditional Chinese medicine, wherein the proportion of each traditional Chinese medicine decoction piece and the formula particles prepared by each traditional Chinese medicine decoction piece is as follows: the mass ratio of semen Hoveniae to the prepared formula particles is 1:0.05, the mass ratio of radix puerariae to the prepared formula particles is 1:0.1, the mass ratio of herba Artemisiae Scopariae to the prepared formula particles is 1:0.089, the mass ratio of rhizoma corydalis to the prepared formula particles is 1:0.069, the mass ratio of flos Chrysanthemi to the prepared formula particles is 1:0.1, the mass ratio of radix glycyrrhizae to the prepared formula particles is 1:0.17, the mass ratio of fructus Jujubae to the prepared formula particles is 1:0.25, the mass ratio of fructus Schisandrae chinensis to the prepared formula particles is 1:0.2, and the mass ratio of rhizoma Alpiniae Officinarum to the prepared formula particles is 1:0.18.
The usage amount is as follows: the wine is taken with boiled water, 5000mg each time, and the wine is taken continuously according to symptoms of drunk people for half an hour after taking, 5000mg each time.
Compared with the prior art, the invention has the beneficial effects that:
(1) The anti-alcohol liver-protecting granule provided by the invention adopts the combination of the medicinal and edible traditional Chinese medicine extract and the biochemical medicine with single active ingredient, fully plays the synergistic effect of the raw materials, has complementary effects and is multiplied.
(2) The anti-alcohol liver-protecting granule provided by the invention can reduce the absorption of alcohol by a human body, accelerate the decomposition of alcohol, prevent alcoholism, reduce the burden of alcohol metabolism of the liver and have a good liver-protecting effect.
(4) The invention has the advantages of simple technical scheme, simple and easily obtained raw materials, obvious effects of dispelling the effects of alcohol and protecting liver and no side effect.
Detailed Description
The present invention is further illustrated below with reference to examples.
Example 1: an anti-alcohol liver-protecting granule is prepared from the following raw materials in parts by weight: 10 parts of semen hoveniae, 10 parts of kudzuvine root, 3 parts of virgate wormwood herb, 3 parts of rhizoma corydalis, 2 parts of chrysanthemum, 5 parts of liquorice, 3 parts of Chinese date, 2 parts of shizandra berry, 6 parts of galangal, 5 parts of corn oligopeptide, 2 parts of honey, 1 part of taurine, 0.5 part of L-cysteine, 0.3 part of inosine, 0.05 part of vitamin C, 0.1 part of compound vitamin B and a proper amount of maltodextrin.
The anti-alcohol liver-protecting granule of the embodiment is prepared by the following steps:
1) Extracting traditional Chinese medicine: the raw materials of the embodiment are respectively extracted by water according to the proportion, namely, hovenia dulcis thunb, kudzuvine root, virgate wormwood herb, rhizoma corydalis, chrysanthemum, liquorice, chinese date, shizandra berry and galangal Chinese medicinal decoction pieces, and the specific water extraction method is as follows:
a. adding purified water 12 times of the quality of the Chinese medicinal decoction pieces into the Chinese medicinal decoction pieces, heating to 90+/-2 ℃ for extraction for 2 hours, filtering, and separating filter residues to obtain primary extraction filtrate and primary extraction residues;
b. adding purified water with the mass 6 times of that of the first extraction residue, heating to 90+/-2 ℃ to extract for 1.5 hours, filtering, and separating filter residues to obtain second extraction filtrate and second extraction residue;
c. performing ultra-high temperature instantaneous sterilization on the first extraction filtrate and the second extraction filtrate, and concentrating the filtrate under reduced pressure at 65 ℃ to obtain clear paste with the relative density of 1.1 g/cm;
d. respectively adding maltodextrin 3% of the mass of the Chinese medicinal decoction pieces into each Chinese medicinal fluid extract, and spray-drying to obtain semen Hoveniae dry extract powder, radix Puerariae dry extract powder, herba Artemisiae Scopariae dry extract powder, YAN Hu Suogan extract powder, flos Chrysanthemi dry extract powder, glycyrrhrizae radix dry extract powder, fructus Jujubae dry extract powder, fructus Schisandrae chinensis dry extract powder, and rhizoma Alpiniae Officinarum dry extract powder.
2) Mixing and granulating: adding semen Hoveniae dry extract powder, radix Puerariae dry extract powder, herba Artemisiae Scopariae dry extract powder, rhizoma Hu Suogan extract powder, flos Chrysanthemi dry extract powder, glycyrrhrizae radix dry extract powder, fructus Jujubae dry extract powder, fructus Schisandrae chinensis dry extract powder, rhizoma Alpiniae Officinarum dry extract powder, semen Maydis oligopeptide, mel, taurine, L-cysteine, inosine, vitamin C, and vitamin B complex into a stirring container, stirring, and dry granulating to obtain anti-hangover and liver protecting granule.
Example 2: the anti-alcohol liver-protecting granule is prepared from the following raw materials in parts by weight: 9 parts of semen hoveniae, 11 parts of kudzuvine root, 2.7 parts of virgate wormwood herb, 3.4 parts of rhizoma corydalis, 1.8 parts of chrysanthemum, 5.5 parts of liquorice, 2.8 parts of Chinese date, 2.2 parts of schisandra chinensis, 5.4 parts of galangal, 5.5 parts of corn oligopeptide, 1.8 parts of honey, 0.8 part of taurine, 0.4 part of L-cysteine, 0.33 part of inosine, 0.06 part of vitamin C, 0.1 part of vitamin B complex and a proper amount of maltodextrin.
The anti-alcohol liver-protecting granule of the embodiment is prepared by the following steps:
1) Extracting traditional Chinese medicine: according to the raw material proportion of the embodiment, hovenia dulcis thunb, kudzuvine root, virgate wormwood herb, rhizoma corydalis, chrysanthemum, liquorice, chinese date, shizandra berry and galangal Chinese herbal pieces are mixed and extracted by water, and the specific water extraction method is as follows:
a. adding purified water with the mass 12 times of that of the Chinese medicinal decoction pieces into the mixed Chinese medicinal decoction pieces, heating to 90+/-2 ℃ for extraction for 2 hours, filtering, and separating filter residues to obtain primary extraction filtrate and primary extraction residues;
b. adding purified water with the mass 6 times of that of the first extraction residue, heating to 90+/-2 ℃ to extract for 1.5 hours, filtering, and separating filter residues to obtain second extraction filtrate and second extraction residue;
c. performing ultra-high temperature instantaneous sterilization on the first extraction filtrate and the second extraction filtrate, and concentrating the filtrate under reduced pressure at 66 ℃ to obtain clear paste with the relative density of 1.05 g/cm;
d. adding maltodextrin accounting for 4% of the mass of the traditional Chinese medicine decoction pieces into the clear paste, and spray-drying to obtain mixed traditional Chinese medicine dry extract powder.
2) Mixing and granulating: mixing the dry extract powder of the traditional Chinese medicine, the corn oligopeptide, the honey, the taurine, the L-cysteine, the inosine, the vitamin C and the vitamin B complex according to the proportion of the raw materials, adding the mixture into a stirring container, stirring uniformly, and granulating by a dry method to obtain the anti-alcohol liver-protecting granule.
Example 3: the anti-alcohol liver-protecting granule is prepared from the following raw materials in parts by weight: semen hoveniae formula particles 0.55 parts (equivalent to 11 parts of semen hoveniae), radix puerariae formula particles 0.80 parts (equivalent to 8 parts), herba artemisiae capillaries formula particles 0.31 parts (equivalent to 3.5 parts), rhizoma corydalis formula particles 0.18 parts (equivalent to 2.6 parts), chrysanthemum formula particles 0.22 parts (equivalent to 2.2 parts), licorice formula particles 0.77 parts (equivalent to 4.5 parts), fructus zizyphi spinosae formula particles 0.88 parts (equivalent to 3.5 parts), schisandra chinensis formula particles 0.36 parts (equivalent to 1.8 parts), rhizoma alpiniae officinarum formula particles 1.19 parts (equivalent to 6.6 parts), corn oligopeptide 4.5 parts, honey 2.2 parts, taurine 1.2 parts, L-cysteine 0.6 parts, inosine 0.27 parts, vitamin C0.04 parts and vitamin B complex 0.1 parts.
The preparation method of the anti-alcohol liver-protecting granule comprises the following steps: the raw materials with the proportion are added into a stirring container to be stirred uniformly, and the anti-alcohol liver-protecting particles are obtained by dry granulation.
Sobering-up experiment for mice
100 healthy Swiss male mice weighing 18-22 g were randomly divided into a model control group, a positive control group, a group of example 1, a group of example 2 and a group of example 3, and 5 groups of 20 mice each. Animals were fasted for 12h without water control before the experiment, the activity status of mice was observed, and the time to alcohol and the time to disappearance of the specular reflection of each group were recorded.
Determination of sobering-up indexes: the time of the disappearance of the specular reflection is based on the condition that the back of the mice is kept downwards for 30 s; the sober-up index is free and flexible to move, and is in the same direction as Mao Hua, namely the recovery time of the regular reflection; record the number of mice drunk: the loss time of the eversion and the recovery time are calculated, and the drunk latency = loss time of the eversion and the alcohol supply time, also called drunk tolerance time; drunk time = recovery time of the eversion-disappearance time of the eversion; sobering-up time = recovery time of flip-flop-time, sobering-up time is a comprehensive manifestation of drunk latency and sleep time.
Each experimental group was dosed as follows, sea Wang Jinzun tablets and anti-hangover liver-protecting granules were dissolved in distilled water to perfuse mice with stomach, diluted at 50mg/ml.
a. Model control group: lavage the stomach according to the weight of the mice with 0.3mL/20g physiological saline; after water is supplied for 30min, the white mice are irrigated with the 56-degree red star Erguotou with the dosage of 0.3mL/20 g;
b. positive control group: the stomach is irrigated by 0.3mL/20g of sea Wang Jinzun tablets according to the weight of the mice; after 30min of administration, the white mice are irrigated with the stomach of 0.3mL/20g dosage of 56 DEG red star Erguotou;
c. example 1 group: the liver-protecting liver-dispelling and anti-alcohol particles prepared in example 1 are infused with 0.3mL/20g of stomach according to the weight of a white mouse; after 30min of administration, the white mice are irrigated with the stomach of 0.3mL/20g dosage of 56 DEG red star Erguotou;
d. example 2 group: the liver-protecting liver-dispelling and anti-alcohol particles prepared in example 2 are infused with 0.3mL/20g of stomach according to the weight of a white mouse; after 30min of administration, the white mice are irrigated with the stomach of 0.3mL/20g dosage of 56 DEG red star Erguotou;
e. example 3 group: the liver-protecting liver-dispelling and anti-alcohol particles prepared in example 3 are infused with 0.3mL/20g of stomach according to the weight of a white mouse; after 30min of administration, the white mice are irrigated with the stomach of 0.3mL/20g dosage of 56 DEG red star Erguotou;
table 1 experimental results of sobering-up test of mice (n=20, x±s)
Figure 329708DEST_PATH_IMAGE002
Note that: compared with the model control group, p is less than 0.05
As can be seen from Table 1, the anti-hangover liver-protecting particles of the examples 1-3 significantly shortened the intoxication time (p < 0.05) of the mice with acute alcoholism, and prolonged the intoxication latency and reduced the intoxication number of the mice, and were significantly different from the model control group (p < 0.05).
Liver protection effect experiment for mice
50 healthy Swiss male mice weighing 18-22 g were randomly divided into a model control group, a positive control group, a group of example 1, a group of example 2 and a group of example 3, and 5 groups of 10 mice each. The experimental animals were normally on diet and were free to drink, and each experimental group was dosed continuously for 21 days, once daily, according to the following schedule:
sea Wang Jinzun tablet and anti-hangover and liver-protecting granule are dissolved in distilled water to perfuse stomach of mice, and the dilution concentration is 50mg/ml.
a. Model control group: lavage the stomach according to the weight of the mice with 0.3mL/20g physiological saline; after water is supplied for 30min, the white mice are irrigated with the 56-degree red star Erguotou with the dosage of 0.3mL/20 g;
b. positive control group: the stomach is irrigated by 0.3mL/20g of sea Wang Jinzun tablets according to the weight of the mice; after 30min of administration, the white mice are irrigated with the stomach of 0.3mL/20g dosage of 56 DEG red star Erguotou;
c. example 1 group: the liver-protecting liver-dispelling and anti-alcohol particles prepared in example 1 are infused with 0.3mL/20g of stomach according to the weight of a white mouse; after 30min of administration, the white mice are irrigated with the stomach of 0.3mL/20g dosage of 56 DEG red star Erguotou;
d. example 2 group: the liver-protecting liver-dispelling and anti-alcohol particles prepared in example 2 are infused with 0.3mL/20g of stomach according to the weight of a white mouse; after 30min of administration, the white mice are irrigated with the stomach of 0.3mL/20g dosage of 56 DEG red star Erguotou;
e. example 3 group: the liver-protecting liver-dispelling and anti-alcohol particles prepared in example 3 are infused with 0.3mL/20g of stomach according to the weight of a white mouse; after 30min of administration, the white mice are irrigated with the stomach of 0.3mL/20g dosage of 56 DEG red star Erguotou;
after the last wine filling on day 21, the mice are fasted for 12 hours, the eyeballs are rapidly picked up to take blood, the eyeballs are stood for 30min, the blood is centrifuged for 10min at 3000r/min, and liver function detection is carried out: alanine Aminotransferase (ALT), aspartic acid Aminotransferase (AST), glutathione peroxidase (GSH-PX), malondialdehyde (MDA).
Table 2 liver function test results (n=10, x±s)
Figure 778007DEST_PATH_IMAGE004
Note that: compared with the model control group, p is less than 0.05
As is clear from Table 2, the AST/ALT and MDA were both significantly decreased (p < 0.05) and GSH-PX was both significantly increased (p < 0.05) in the groups of examples 1 to 3, as compared with the model control group. The anti-alcohol liver-protecting particles can effectively reduce the ALT, AST, MDA content in the liver, raise the GSH-PX content and have obvious protective effect on alcoholic liver injury.

Claims (9)

1. The anti-alcohol liver-protecting granule is prepared from the following raw materials in parts by weight: 8 to 12 parts of semen hoveniae, 8 to 12 parts of kudzuvine root, 2.4 to 3.6 parts of virgate wormwood herb, 2.4 to 3.6 parts of rhizoma corydalis, 1.6 to 2.4 parts of chrysanthemum, 4 to 6 parts of liquorice, 2.4 to 3.6 parts of jujube, 1.6 to 2.4 parts of schisandra chinensis, 4.8 to 7.2 parts of galangal, 4 to 6 parts of corn oligopeptide, 1.6 to 2.4 parts of honey, 0.8 to 1.2 parts of taurine, 0.4 to 0.6 part of L-cysteine, 0.24 to 0.36 part of inosine, 0.04 to 0.06 part of vitamin C, 0.08 to 0.12 part of vitamin B complex and a proper amount of auxiliary materials.
2. The anti-hangover liver-protecting granule recited in claim 1, wherein: the material is prepared from the following raw materials in parts by weight: 9 to 11 parts of semen hoveniae, 9 to 11 parts of kudzuvine root, 2.7 to 3.3 parts of virgate wormwood herb, 2.7 to 3.3 parts of rhizoma corydalis, 1.8 to 2.2 parts of chrysanthemum, 4.5 to 5.5 parts of liquorice, 2.7 to 3.3 parts of jujube, 1.8 to 2.2 parts of schisandra chinensis, 5.4 to 6.6 parts of galangal, 4.5 to 5.5 parts of corn oligopeptide, 1.8 to 2.2 parts of honey, 0.9 to 1.1 part of taurine, 0.45 to 0.55 part of L-cysteine, 0.27 to 0.33 part of inosine, 0.045 to 0.055 part of vitamin C, 0.09 to 0.11 part of compound vitamin B and a proper amount of auxiliary materials.
3. The anti-hangover liver-protecting granule recited in claim 2, wherein: the material is prepared from the following raw materials in parts by weight: 10 parts of semen hoveniae, 10 parts of kudzuvine root, 3 parts of virgate wormwood herb, 3 parts of rhizoma corydalis, 2 parts of chrysanthemum, 5 parts of liquorice, 3 parts of Chinese date, 2 parts of shizandra berry, 6 parts of galangal, 5 parts of corn oligopeptide, 2 parts of honey, 1 part of taurine, 0.5 part of L-cysteine, 0.3 part of inosine, 0.05 part of vitamin C, 0.1 part of vitamin B complex and a proper amount of auxiliary materials.
4. A liver protecting anti-hangover granule according to any one of claims 1 to 3, characterised in that: the auxiliary materials are one or more of soluble starch, sucrose powder, dextrin, lactose and maltodextrin.
5. The preparation method of the anti-alcohol liver-protecting granule as claimed in claim 4, comprising the following steps:
1) Extracting traditional Chinese medicine: respectively extracting semen Hoveniae, radix Puerariae, herba Artemisiae Scopariae, rhizoma corydalis, flos Chrysanthemi, glycyrrhrizae radix, fructus Jujubae, fructus Schisandrae chinensis and rhizoma Alpiniae Officinarum with water, filtering, concentrating under reduced pressure to obtain fluid extract with relative density of 1.01-1.20 g/cm, adding adjuvant into the fluid extract, and spray drying to obtain semen Hoveniae dry extract powder, radix Puerariae dry extract powder, herba Artemisiae Scopariae dry extract powder, rhizoma Hu Suogan dry extract powder, flos Chrysanthemi dry extract powder, glycyrrhrizae radix dry extract powder, fructus Jujubae dry extract powder, fructus Schisandrae chinensis dry extract powder and rhizoma Alpiniae Officinarum dry extract powder;
2) Mixing and granulating: adding semen Hoveniae dry extract powder, radix Puerariae dry extract powder, herba Artemisiae Scopariae dry extract powder, rhizoma Hu Suogan extract powder, flos Chrysanthemi dry extract powder, glycyrrhrizae radix dry extract powder, fructus Jujubae dry extract powder, fructus Schisandrae chinensis dry extract powder, rhizoma Alpiniae Officinarum dry extract powder, semen Maydis oligopeptide, mel, taurine, L-cysteine, inosine, vitamin C, and vitamin B complex into a stirring container, stirring, and dry granulating to obtain anti-hangover and liver protecting granule.
6. The preparation method of the anti-alcohol liver-protecting granule as claimed in claim 4, comprising the following steps:
1) Extracting traditional Chinese medicine: mixing semen Hoveniae, radix puerariae, herba artemisiae scopariae, rhizoma corydalis, chrysanthemum, liquorice, chinese date, schisandra chinensis and galangal Chinese herbal pieces according to the raw material proportion, extracting with water, filtering, concentrating under reduced pressure to obtain fluid extract with the relative density of 1.01-1.20 g/cm, adding a proper amount of auxiliary materials into the fluid extract, and spray drying to obtain mixed Chinese herbal dry extract powder;
2) Mixing and granulating: mixing the dry extract powder of the traditional Chinese medicine, the corn oligopeptide, the honey, the taurine, the L-cysteine, the inosine, the vitamin C and the vitamin B complex according to the proportion of the raw materials, adding the mixture into a stirring container, stirring uniformly, and granulating by a dry method to obtain the anti-alcohol liver-protecting granule.
7. The method for preparing the anti-alcohol liver-protecting granule according to claim 5, which is characterized in that: the traditional Chinese medicine extraction step comprises the following steps:
a. adding purified water which is 6-15 times of the quality of the traditional Chinese medicine decoction pieces into the traditional Chinese medicine decoction pieces, heating for extraction, filtering, and separating filter residues to obtain primary extraction filtrate and primary extraction residues;
b. adding purified water with the mass 5-8 times of that of the first extraction residue into the first extraction residue, heating for extraction, filtering, and separating the residue to obtain second extraction filtrate and second extraction residue;
c. carrying out ultra-high temperature instantaneous sterilization on the first extraction filtrate and the second extraction filtrate, and concentrating the filtrate under reduced pressure at 50-70 ℃ to obtain clear paste with the relative density of 1.01-1.20 g/cm;
d. adding appropriate amount of adjuvant into the fluid extract, dissolving, and spray drying to obtain dry extract powder.
8. The method for preparing the anti-alcohol liver-protecting granule according to claim 6, which is characterized in that: the traditional Chinese medicine extraction step comprises the following steps:
a. adding purified water which is 6-15 times of the quality of the traditional Chinese medicine decoction pieces into the traditional Chinese medicine decoction pieces, heating for extraction, filtering, and separating filter residues to obtain primary extraction filtrate and primary extraction residues;
b. adding purified water with the mass 5-8 times of that of the first extraction residue into the first extraction residue, heating for extraction, filtering, and separating the residue to obtain second extraction filtrate and second extraction residue;
c. carrying out ultra-high temperature instantaneous sterilization on the first extraction filtrate and the second extraction filtrate, and concentrating the filtrate under reduced pressure at 50-70 ℃ to obtain clear paste with the relative density of 1.01-1.20 g/cm;
d. adding appropriate amount of adjuvant into the fluid extract, dissolving, and spray drying to obtain dry extract powder.
9. The method for preparing the anti-alcohol liver-protecting granule according to claim 4, which is characterized in that: the traditional Chinese medicine raw materials are directly mixed and granulated by using the formula granules of each traditional Chinese medicine and the rest raw materials; the dosage proportion of the formula particles of each traditional Chinese medicine is calculated according to the proportion of the formula particles prepared by each traditional Chinese medicine, wherein the proportion of each traditional Chinese medicine decoction piece and the formula particles prepared by each traditional Chinese medicine decoction piece is as follows: the mass ratio of semen Hoveniae to the prepared formula particles is 1:0.05, the mass ratio of radix puerariae to the prepared formula particles is 1:0.1, the mass ratio of herba Artemisiae Scopariae to the prepared formula particles is 1:0.089, the mass ratio of rhizoma corydalis to the prepared formula particles is 1:0.069, the mass ratio of flos Chrysanthemi to the prepared formula particles is 1:0.1, the mass ratio of radix glycyrrhizae to the prepared formula particles is 1:0.17, the mass ratio of fructus Jujubae to the prepared formula particles is 1:0.25, the mass ratio of fructus Schisandrae chinensis to the prepared formula particles is 1:0.2, and the mass ratio of rhizoma Alpiniae Officinarum to the prepared formula particles is 1:0.18.
CN202211306463.1A 2022-10-25 2022-10-25 Anti-alcohol liver-protecting granule and preparation method thereof Pending CN116077617A (en)

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