CN1160717A - Preparation of glycerophosphoric acid - Google Patents
Preparation of glycerophosphoric acid Download PDFInfo
- Publication number
- CN1160717A CN1160717A CN 96112580 CN96112580A CN1160717A CN 1160717 A CN1160717 A CN 1160717A CN 96112580 CN96112580 CN 96112580 CN 96112580 A CN96112580 A CN 96112580A CN 1160717 A CN1160717 A CN 1160717A
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- China
- Prior art keywords
- phosphoric acid
- preparation
- glycerine
- glycerol esters
- reaction
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- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
The preparation of glycerophosphoric acid uses medicine-level glycerine and food-level phosphoric acid in the molar ratio not greater than 1 as material and includes their reaction at 120-150 deg.C and vacuum state for 4-7 hr, and the cooling, hydrolysis with deionized water and decoloring with carboraffin of reacted solution, filtering and packing. The present invention has simple technological process and high material conversion rate.
Description
The present invention relates to a kind of preparation method of Phosphoric acid glycerol esters.
Phosphoric acid glycerol esters can be used for making the salt aspect as nutritional supplement, also must use Phosphoric acid glycerol esters in the international advanced vitamin B12 production technique, and China does not still have the production technology of this Phosphoric acid glycerol esters.
The objective of the invention is to overcome the deficiency of above-mentioned prior art, a kind of preparation method of Phosphoric acid glycerol esters is provided, this method technology is simple, the feed stock conversion height.
The objective of the invention is to realize by following proposal:
The preparation method of Phosphoric acid glycerol esters makes raw material with pharmaceutical grade glycerine and food grade phosphoric acid, the ratio of components of the two (mol ratio) is: glycerine: phosphoric acid≤1.0, the glycerine and the phosphoric acid of said ratio are reacted, temperature of reaction is 120 ℃-150 ℃, and reaction pressure is a vacuum, and the reaction times is 4-7 hour, reacted solution is lowered the temperature, add the deionized water hydrolysis, with a sugar level activated carbon decolorizing, filter then, pack again.
The Phosphoric acid glycerol esters that present method is produced is the miscellany of asymmetric alpha-acid and symmetrical β-acid, and its percentage composition also is the total content of mixture.
Batch production practice check surplus 200, the present invention has the following advantages:
1, the Phosphoric acid glycerol esters of producing with the present invention, production practice checking through Hebei Wei Keda pharmaceutical Co. Ltd over 3 years, meet the manufacturing technique requirent that the said firm produces vitamin B12 fully, and the Phosphoric acid glycerol esters steady quality that this method is produced, meet Jinzhou City chemical plant company standard Q/JDS01-1996 greatly still, leading indicator:
1. content % 〉=35 of Phosphoric acid glycerol esters
2. free phosphoric acid is (with P
2O
5Meter) content %≤5
3. heavy metal (in Pb) content %≤0.001
4. arsenic (in As) content %≤0.0005
5. outward appearance is colourless or light yellow clarifying transparent liquid.
2, product yield height.Pharmaceutical grade glycerine per ton can be produced the 4.6-5 ton and contain Phosphoric acid glycerol esters at the product more than 35%, and the product yield under top condition (in glycerine) can reach 95%-99%.
3, this method technology is simple.
A specific embodiments of the present invention is described below:
250 kilograms of pharmaceutical grade glycerine and 298 kilograms of food grade phosphoric acids are dropped in the retort, stir vacuum, be warming up to 140 ℃, finish through reaction in 4 hours, cooling adds deionized water, hydrolysis, stir, with the level activated carbon decolorizing, remove by filter gac and impurity with 4 kilograms of sugar, produce 1000 kilograms of products, through chemical examination Phosphoric acid glycerol esters content is 35.3%, and free phosphoric acid is (with P
2O
5Meter) content is 3.3%, and product yield (in glycerine) is 97.73%.
Claims (2)
1, a kind of preparation method of Phosphoric acid glycerol esters is characterized in that its adopts pharmaceutical grade glycerine and food grade phosphoric acid to make raw material, and the ratio of components of the two (mol ratio) is: glycerine: phosphoric acid≤1.0; The glycerine and the phosphoric acid of said ratio are reacted, and temperature of reaction is 120 ℃-150 ℃, and reaction pressure is a vacuum, and the reaction times is 4-7 hour; With the reacted solution cooling, add the deionized water hydrolysis, with a sugar level activated carbon decolorizing, filter then, pack again.
2, the preparation method of Phosphoric acid glycerol esters according to claim 1 is characterized in that the consumption of activated carbon accounts for the 0.3%-0.5% of product weight.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 96112580 CN1160717A (en) | 1996-09-20 | 1996-09-20 | Preparation of glycerophosphoric acid |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 96112580 CN1160717A (en) | 1996-09-20 | 1996-09-20 | Preparation of glycerophosphoric acid |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1160717A true CN1160717A (en) | 1997-10-01 |
Family
ID=5121512
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 96112580 Pending CN1160717A (en) | 1996-09-20 | 1996-09-20 | Preparation of glycerophosphoric acid |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1160717A (en) |
-
1996
- 1996-09-20 CN CN 96112580 patent/CN1160717A/en active Pending
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C01 | Deemed withdrawal of patent application (patent law 1993) |