CN1026488C - Preparation method of high purity medical calcium citrate using general calcium lime and edible citric acid - Google Patents
Preparation method of high purity medical calcium citrate using general calcium lime and edible citric acid Download PDFInfo
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- CN1026488C CN1026488C CN 92104844 CN92104844A CN1026488C CN 1026488 C CN1026488 C CN 1026488C CN 92104844 CN92104844 CN 92104844 CN 92104844 A CN92104844 A CN 92104844A CN 1026488 C CN1026488 C CN 1026488C
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- citric acid
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Abstract
The present invention relates to a method for preparing high-purity medicinal calcium citrate from common quicklime and edible citric acid, which has the technical scheme that the common quicklime, ammonium chloride and water are proportionally prepared into a solution; carbon dioxide is added in the solution for carbonation after filtering and clarification; then, powder A is obtained through dewatering, washing, dewatering, drying, cooling, pulverization and sieving; the powder A through the processing, edible citric acid and water are proportionally prepared into a solution and are reacted at a certain temperature; the high-purity medicinal calcium citrate is obtained through dewatering, washing, dewatering, drying and sieving after the reaction is completely finished. The high-purity medicinal calcium citrate is used as a good calcium supplement agent and has high medicinal value.
Description
The present invention relates to a kind of method of utilizing ordinary student lime and edible citric acid to produce the high purity medical citrate of lime.
According to the pertinent data reports of newspaper, at present 50% the common calcium deficiency of children, old man is arranged at the international level, pharmaceutically all adopting calglucon and calcium lactate as calsium supplement in the past, but take above-mentioned two kinds of calsium supplements human body is brought two big disadvantages.One, after taking, human body is very slow to its absorption, and it two makes human body produce various lithiasis after taking easily.Can avoid above-mentioned two kinds of disadvantages and take the high purity medical citrate of lime, this has brought Gospel to calcium deficiency person.
Disclose a kind of high-quality medicinal calcium carbonate and edible citric acid and water of utilizing at present in the world, be used for producing the method for citrate of lime.In order to obtain the high-quality medicinal calcium carbonate, traditional technology all adopts the calcium chloride carborization, earlier unslaked lime and hydrochloric acid effect are generated calcium chloride and carbon dioxide, then calcium chloride is added ammonium hydroxide again after purifying, carry out carbonization with carbon dioxide again, so old technology will consume a large amount of salt and ammonium hydroxide in process of production, production cost is very high.
The invention provides a kind of brand-new processing method, directly utilize ordinary student lime and edible citric acid, adopted special production technique directly to make the high purity medical citrate of lime, this its grade of high purity medical citrate of lime is high, and quality product meets and exceeds the standard of American Pharmacopeia (USP-22).And in process of production not with hydrochloric acid and ammonium hydroxide, so production cost reduces significantly.
Technical characterictic of the present invention is:
A. remove various impurity in the ordinary student lime, promptly by following weight ratio unslaked lime: ammonium chloride: water=(1～1.3): 2: (8～10) wiring solution-forming, through fully stirring after-filtration, clarification.
B. feed above-mentioned solution with carbon dioxide, till reaction solution pH≤7 o'clock.
C. again with above-mentioned reaction solution through dehydration, washing, dehydration, dry, cool off, pulverize, screen powder A.
D. with this after above-mentioned a to c step process powder A and edible citric acid and water by following weight ratio (25～35): (38～43): 150 wiring solution-formings react, and its temperature of reaction is controlled between 70 ℃～100 ℃.
E. after question response is ended fully, promptly get the high purity medical citrate of lime through dehydration, washing, dehydration, drying, screening.
The present invention compared with prior art has the following advantages: product grade and quality height, and the product purity height, production cost is low.
Embodiments of the invention:
1. get ordinary student lime by following weight ratio ordinary student lime: ammonium chloride: water=1.1: 2: 10 wiring solution-formings, after filtration, the clarification back feeds carbon dioxide and carry out carbonization.Till pH≤7 o'clock, through dehydration, washing, dehydration, dry, cool off, pulverize, screen powder A, powder A after again above-mentioned steps being handled and edible citric acid and water react, temperature of reaction is 90 ℃, powder A: citric acid: water=30: 42: 150, again through dehydration, washing, dehydration, dry, screening, its quality index of products obtained therefrom was after question response finished fully:
Citrate of lime content 99.2% arsenic content＜3ppM
Heavy metal content＜0.002% lead content＜0.001%
Hydrochloric acid insoluble substance content 0.02% content of fluoride is qualified
2. get ordinary student lime by following weight ratio ordinary student lime: ammonium chloride: water=1.2: 2: 9.5 wiring solution-formings, clarification back feeding carbon dioxide carries out carbonization after filtration, till pH≤7 o'clock, through dehydration, washing, dehydration, dry, cooling, pulverize, screen powder A, powder A that again will be after above-mentioned steps is handled and edible citric acid and water react, temperature of reaction is 85 ℃, powder A: citric acid: water=30: 42: 150, after question response finishes fully, again through dehydration, washing, dehydration, dry, screening, its quality index of products obtained therefrom is:
Citrate of lime content 98.8% arsenic content＜3ppM
Heavy metal content＜0.002% lead content＜0.001%
Hydrochloric acid insoluble substance content 0.03% content of fluoride is qualified
Claims (1)
1, a kind of method of utilizing ordinary student lime and edible citric acid to produce the high purity medical citrate of lime.
It is characterized in that:
A. remove various impurity in the ordinary student lime, promptly by following weight ratio unslaked lime: ammonium chloride: water=(1～1.3): 2: (8～10).Wiring solution-forming is through fully stirring the after-filtration clarification.
B. feed above-mentioned solution with carbon dioxide, till reaction solution pH≤7 o'clock.
C. again with above-mentioned reaction solution through dehydration, washing, dehydration, dry, cool off, pulverize, screen powder A.
D. with this powder A and edible citric acid and water after above-mentioned a to c step process, by following weight ratio (25～35): (38～43): 150 wiring solution-formings react, and its temperature of reaction is controlled between 70 ℃～100 ℃.
E. after question response is ended fully, promptly get the high purity medical citrate of lime through dehydration, washing, dehydration, drying, screening.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 92104844 CN1026488C (en) | 1992-06-25 | 1992-06-25 | Preparation method of high purity medical calcium citrate using general calcium lime and edible citric acid |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 92104844 CN1026488C (en) | 1992-06-25 | 1992-06-25 | Preparation method of high purity medical calcium citrate using general calcium lime and edible citric acid |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1066443A CN1066443A (en) | 1992-11-25 |
| CN1026488C true CN1026488C (en) | 1994-11-09 |
Family
ID=4941029
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 92104844 Expired - Fee Related CN1026488C (en) | 1992-06-25 | 1992-06-25 | Preparation method of high purity medical calcium citrate using general calcium lime and edible citric acid |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1026488C (en) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1085196C (en) * | 1999-09-02 | 2002-05-22 | 邹纪平 | Active calcium citrate and its synthesizing process and equipment |
| CN101348431B (en) * | 2007-07-20 | 2013-03-27 | 南通市飞宇精细化学品有限公司 | Method for producing low lead light density granular calcium citrate |
| CN102557920B (en) * | 2011-12-22 | 2014-08-20 | 日照金禾博源生化有限公司 | Process for producing calcium citrate |
| CN106146290A (en) * | 2015-04-02 | 2016-11-23 | 中粮生物化学（安徽）股份有限公司 | A kind of method producing calcium citrate salts |
-
1992
- 1992-06-25 CN CN 92104844 patent/CN1026488C/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| CN1066443A (en) | 1992-11-25 |
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| Date | Code | Title | Description |
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| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C06 | Publication | ||
| PB01 | Publication | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| C15 | Extension of patent right duration from 15 to 20 years for appl. with date before 31.12.1992 and still valid on 11.12.2001 (patent law change 1993) | ||
| OR01 | Other related matters | ||
| C19 | Lapse of patent right due to non-payment of the annual fee | ||
| CF01 | Termination of patent right due to non-payment of annual fee |