CN116058377A - Use of bactericidal composition containing mandipropamid and oxazomet for preventing and treating grape downy mildew - Google Patents
Use of bactericidal composition containing mandipropamid and oxazomet for preventing and treating grape downy mildew Download PDFInfo
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- CN116058377A CN116058377A CN202310102718.0A CN202310102718A CN116058377A CN 116058377 A CN116058377 A CN 116058377A CN 202310102718 A CN202310102718 A CN 202310102718A CN 116058377 A CN116058377 A CN 116058377A
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- mandipropamid
- downy mildew
- bactericidal composition
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- 239000000203 mixture Substances 0.000 title claims abstract description 52
- KWLVWJPJKJMCSH-UHFFFAOYSA-N 2-(4-chlorophenyl)-N-{2-[3-methoxy-4-(prop-2-yn-1-yloxy)phenyl]ethyl}-2-(prop-2-yn-1-yloxy)acetamide Chemical compound C1=C(OCC#C)C(OC)=CC(CCNC(=O)C(OCC#C)C=2C=CC(Cl)=CC=2)=C1 KWLVWJPJKJMCSH-UHFFFAOYSA-N 0.000 title claims abstract description 51
- 241000233679 Peronosporaceae Species 0.000 title claims abstract description 51
- 239000005804 Mandipropamid Substances 0.000 title claims abstract description 49
- 235000009754 Vitis X bourquina Nutrition 0.000 title claims abstract description 40
- 235000012333 Vitis X labruscana Nutrition 0.000 title claims abstract description 40
- 235000014787 Vitis vinifera Nutrition 0.000 title claims abstract description 40
- 230000000844 anti-bacterial effect Effects 0.000 title claims abstract description 22
- 240000006365 Vitis vinifera Species 0.000 title 1
- 241000219095 Vitis Species 0.000 claims abstract description 39
- 229960002026 pyrithione Drugs 0.000 claims abstract description 13
- FGVVTMRZYROCTH-UHFFFAOYSA-N pyridine-2-thiol N-oxide Chemical compound [O-][N+]1=CC=CC=C1S FGVVTMRZYROCTH-UHFFFAOYSA-N 0.000 claims abstract description 12
- 239000004480 active ingredient Substances 0.000 claims abstract description 11
- HNJBEVLQSNELDL-UHFFFAOYSA-N pyrrolidin-2-one Chemical compound O=C1CCCN1 HNJBEVLQSNELDL-UHFFFAOYSA-N 0.000 claims abstract description 3
- 201000010099 disease Diseases 0.000 claims description 33
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 33
- 239000003795 chemical substances by application Substances 0.000 claims description 28
- 238000002360 preparation method Methods 0.000 claims description 26
- 239000000839 emulsion Substances 0.000 claims description 16
- 239000000375 suspending agent Substances 0.000 claims description 13
- 239000000725 suspension Substances 0.000 claims description 11
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- 238000009472 formulation Methods 0.000 claims description 8
- 239000003094 microcapsule Substances 0.000 claims description 8
- 241001281803 Plasmopara viticola Species 0.000 claims description 6
- 239000008187 granular material Substances 0.000 claims description 6
- 239000000843 powder Substances 0.000 claims description 6
- 239000002904 solvent Substances 0.000 claims description 5
- -1 strips Substances 0.000 claims description 5
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- 239000004530 micro-emulsion Substances 0.000 claims description 2
- 239000004533 oil dispersion Substances 0.000 claims description 2
- 239000002674 ointment Substances 0.000 claims description 2
- 239000003755 preservative agent Substances 0.000 claims description 2
- 239000004551 spreading oil Substances 0.000 claims description 2
- 239000003381 stabilizer Substances 0.000 claims description 2
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- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 7
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 6
- 230000018109 developmental process Effects 0.000 description 6
- 229940051841 polyoxyethylene ether Drugs 0.000 description 6
- 229920000056 polyoxyethylene ether Polymers 0.000 description 6
- 238000004166 bioassay Methods 0.000 description 5
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- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 4
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- 238000005507 spraying Methods 0.000 description 4
- 238000007619 statistical method Methods 0.000 description 4
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 3
- 229910019142 PO4 Inorganic materials 0.000 description 3
- 241000233622 Phytophthora infestans Species 0.000 description 3
- 241000233626 Plasmopara Species 0.000 description 3
- 230000000996 additive effect Effects 0.000 description 3
- 238000004458 analytical method Methods 0.000 description 3
- 239000003899 bactericide agent Substances 0.000 description 3
- 230000004071 biological effect Effects 0.000 description 3
- 238000013329 compounding Methods 0.000 description 3
- 150000001875 compounds Chemical class 0.000 description 3
- 239000008367 deionised water Substances 0.000 description 3
- 229910021641 deionized water Inorganic materials 0.000 description 3
- 239000012153 distilled water Substances 0.000 description 3
- 235000013399 edible fruits Nutrition 0.000 description 3
- 239000000463 material Substances 0.000 description 3
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 3
- 239000010452 phosphate Substances 0.000 description 3
- 229920002545 silicone oil Polymers 0.000 description 3
- 239000000230 xanthan gum Substances 0.000 description 3
- 229920001285 xanthan gum Polymers 0.000 description 3
- 229940082509 xanthan gum Drugs 0.000 description 3
- 235000010493 xanthan gum Nutrition 0.000 description 3
- IAQLCKZJGNTRDO-UHFFFAOYSA-N 1-(4-{4-[5-(2,6-difluorophenyl)-4,5-dihydro-1,2-oxazol-3-yl]-1,3-thiazol-2-yl}piperidin-1-yl)-2-[5-methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl]ethanone Chemical compound CC1=CC(C(F)(F)F)=NN1CC(=O)N1CCC(C=2SC=C(N=2)C=2CC(ON=2)C=2C(=CC=CC=2F)F)CC1 IAQLCKZJGNTRDO-UHFFFAOYSA-N 0.000 description 2
- 241000233654 Oomycetes Species 0.000 description 2
- 241001281805 Pseudoperonospora cubensis Species 0.000 description 2
- 229930182558 Sterol Natural products 0.000 description 2
- PPBRXRYQALVLMV-UHFFFAOYSA-N Styrene Chemical compound C=CC1=CC=CC=C1 PPBRXRYQALVLMV-UHFFFAOYSA-N 0.000 description 2
- 125000002877 alkyl aryl group Chemical group 0.000 description 2
- 230000008485 antagonism Effects 0.000 description 2
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- 230000002301 combined effect Effects 0.000 description 2
- 238000012258 culturing Methods 0.000 description 2
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- 238000011081 inoculation Methods 0.000 description 2
- 230000002045 lasting effect Effects 0.000 description 2
- 238000007726 management method Methods 0.000 description 2
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 description 2
- 229920000053 polysorbate 80 Polymers 0.000 description 2
- WXMKPNITSTVMEF-UHFFFAOYSA-M sodium benzoate Chemical compound [Na+].[O-]C(=O)C1=CC=CC=C1 WXMKPNITSTVMEF-UHFFFAOYSA-M 0.000 description 2
- 239000004299 sodium benzoate Substances 0.000 description 2
- 235000010234 sodium benzoate Nutrition 0.000 description 2
- 239000007921 spray Substances 0.000 description 2
- 150000003432 sterols Chemical class 0.000 description 2
- 235000003702 sterols Nutrition 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 238000005406 washing Methods 0.000 description 2
- IKHGUXGNUITLKF-UHFFFAOYSA-N Acetaldehyde Chemical compound CC=O IKHGUXGNUITLKF-UHFFFAOYSA-N 0.000 description 1
- 241000037488 Coccoloba pubescens Species 0.000 description 1
- 235000009849 Cucumis sativus Nutrition 0.000 description 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 1
- 208000031888 Mycoses Diseases 0.000 description 1
- 244000061176 Nicotiana tabacum Species 0.000 description 1
- 235000002637 Nicotiana tabacum Nutrition 0.000 description 1
- 208000030852 Parasitic disease Diseases 0.000 description 1
- 241001223281 Peronospora Species 0.000 description 1
- 231100000674 Phytotoxicity Toxicity 0.000 description 1
- 229920003171 Poly (ethylene oxide) Polymers 0.000 description 1
- 241000221696 Sclerotinia sclerotiorum Species 0.000 description 1
- 239000004283 Sodium sorbate Substances 0.000 description 1
- 241000219094 Vitaceae Species 0.000 description 1
- 241000607479 Yersinia pestis Species 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 230000002411 adverse Effects 0.000 description 1
- 150000001408 amides Chemical class 0.000 description 1
- QKZIVVMOMKTVIK-UHFFFAOYSA-M anilinomethanesulfonate Chemical compound [O-]S(=O)(=O)CNC1=CC=CC=C1 QKZIVVMOMKTVIK-UHFFFAOYSA-M 0.000 description 1
- 230000003042 antagnostic effect Effects 0.000 description 1
- 239000002518 antifoaming agent Substances 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 239000012752 auxiliary agent Substances 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000000903 blocking effect Effects 0.000 description 1
- 238000004820 blood count Methods 0.000 description 1
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- 230000001934 delay Effects 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- YDEXUEFDPVHGHE-GGMCWBHBSA-L disodium;(2r)-3-(2-hydroxy-3-methoxyphenyl)-2-[2-methoxy-4-(3-sulfonatopropyl)phenoxy]propane-1-sulfonate Chemical compound [Na+].[Na+].COC1=CC=CC(C[C@H](CS([O-])(=O)=O)OC=2C(=CC(CCCS([O-])(=O)=O)=CC=2)OC)=C1O YDEXUEFDPVHGHE-GGMCWBHBSA-L 0.000 description 1
- GVGUFUZHNYFZLC-UHFFFAOYSA-N dodecyl benzenesulfonate;sodium Chemical compound [Na].CCCCCCCCCCCCOS(=O)(=O)C1=CC=CC=C1 GVGUFUZHNYFZLC-UHFFFAOYSA-N 0.000 description 1
- 230000002888 effect on disease Effects 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 150000002191 fatty alcohols Chemical class 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- NVVZQXQBYZPMLJ-UHFFFAOYSA-N formaldehyde;naphthalene-1-sulfonic acid Chemical compound O=C.C1=CC=C2C(S(=O)(=O)O)=CC=CC2=C1 NVVZQXQBYZPMLJ-UHFFFAOYSA-N 0.000 description 1
- 230000000855 fungicidal effect Effects 0.000 description 1
- 230000035784 germination Effects 0.000 description 1
- 235000021021 grapes Nutrition 0.000 description 1
- 231100000171 higher toxicity Toxicity 0.000 description 1
- 230000003834 intracellular effect Effects 0.000 description 1
- 230000001788 irregular Effects 0.000 description 1
- 238000002955 isolation Methods 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 230000003020 moisturizing effect Effects 0.000 description 1
- 239000010413 mother solution Substances 0.000 description 1
- 231100000989 no adverse effect Toxicity 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 244000052769 pathogen Species 0.000 description 1
- 230000001717 pathogenic effect Effects 0.000 description 1
- 150000003904 phospholipids Chemical class 0.000 description 1
- 230000004260 plant-type cell wall biogenesis Effects 0.000 description 1
- 229920002503 polyoxyethylene-polyoxypropylene Polymers 0.000 description 1
- 229920001451 polypropylene glycol Polymers 0.000 description 1
- 229940121649 protein inhibitor Drugs 0.000 description 1
- 239000012268 protein inhibitor Substances 0.000 description 1
- VTGOHKSTWXHQJK-UHFFFAOYSA-N pyrimidin-2-ol Chemical compound OC1=NC=CC=N1 VTGOHKSTWXHQJK-UHFFFAOYSA-N 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 238000005070 sampling Methods 0.000 description 1
- 238000010008 shearing Methods 0.000 description 1
- 230000011664 signaling Effects 0.000 description 1
- 229940080264 sodium dodecylbenzenesulfonate Drugs 0.000 description 1
- LROWVYNUWKVTCU-STWYSWDKSA-M sodium sorbate Chemical compound [Na+].C\C=C\C=C\C([O-])=O LROWVYNUWKVTCU-STWYSWDKSA-M 0.000 description 1
- 235000019250 sodium sorbate Nutrition 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 230000004763 spore germination Effects 0.000 description 1
- 150000003900 succinic acid esters Chemical class 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 230000009885 systemic effect Effects 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
- 238000012876 topography Methods 0.000 description 1
- 235000013311 vegetables Nutrition 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/72—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms
- A01N43/80—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms five-membered rings with one nitrogen atom and either one oxygen atom or one sulfur atom in positions 1,2
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N37/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids
- A01N37/36—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids containing at least one carboxylic group or a thio analogue, or a derivative thereof, and a singly bound oxygen or sulfur atom attached to the same carbon skeleton, this oxygen or sulfur atom not being a member of a carboxylic group or of a thio analogue, or of a derivative thereof, e.g. hydroxy-carboxylic acids
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01P—BIOCIDAL, PEST REPELLANT, PEST ATTRACTANT OR PLANT GROWTH REGULATORY ACTIVITY OF CHEMICAL COMPOUNDS OR PREPARATIONS
- A01P3/00—Fungicides
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Wood Science & Technology (AREA)
- Environmental Sciences (AREA)
- Pest Control & Pesticides (AREA)
- Plant Pathology (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Dentistry (AREA)
- Agronomy & Crop Science (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
The invention belongs to the technical field of agricultural sterilization, and discloses an application of a sterilization composition containing mandipropamid and oxazoyl pyrrolidone in preventing and treating grape downy mildew. The bactericidal composition comprises active ingredients A mandipropamid and active ingredients B fluorothiazole pyrithione, wherein the mass ratio of the mandipropamid to the fluorothiazole pyrithione is 25:1-2:25, and the bactericidal composition is used for preventing and controlling grape downy mildew caused by grape monoaxial mould, has obvious prevention effect and long lasting period, can effectively slow down the generation and development of drug resistance of pathogenic bacteria, and is environment-friendly.
Description
Technical Field
The invention belongs to the technical field of pesticide sterilization, and discloses an application of a sterilization composition containing mandipropamid and oxazoyl pyrrolidone in preventing and treating grape downy mildew.
Background
Downy mildew of grape is an obligate parasitic disease, one of the most serious fungal diseases that endanger grapes. The pathogenic bacteria of grape downy mildew is Plasmopara viticola (Plasmopara viticola), which belongs to the genus Plasmopara of the family Plasmopara of the order Plasmopara of the phylum Trimerella, and is mainly responsible for the damage to tender organs, leaves, tender tips, and young fruits of plants. When the disease flows severely, the leaf is burnt and early fallen, the branch tip is distorted and deformed, the young fruit is covered with white mould layer and is wrinkled and fallen, the grape growth and the fruit yield and quality are seriously affected, and great economic loss is caused for the grape industry.
Mandipropamid, international generic name: mandipropamid, chemical name: 2- (4-chlorophenyl) -N- [2- (3-methoxy-4-prop-2-ynyloxyphenyl) ethyl ] -2-prop-2-ynyloxyacetamide, CAS No.: 374726-62-2. Mandipropamid is a mandelic amide compound developed from Zhengda, and has good control effect on diseases caused by oomycete pathogenic bacteria. It can inhibit phospholipid biosynthesis and cell wall synthesis, has high activity on spore in germination stage, and can inhibit hypha growth and spore germination. The structural formula is as follows:
fluothiapyr ethanone, international generic name: oxathiaapipin, chemical name: 1- [4- [4- [5- (2, 6-difluorophenyl) -4, 5-dihydro-1, 2-oxazol-3-yl ] -1, 3-thiazol-2-yl ] piperidin-1-yl ] -2- [ 5-methyl-3- (trifluoromethyl) pyrazol-1-yl ] ethanone, CAS no: 1003318-67-9. Fluozolpidem is an oxidized sterol protein inhibitor that can cause pathogen death by blocking intracellular lipid biosynthesis, sterol transport, and signaling. The fluorothiazole pyrithione has excellent systemic conductivity and can be transported in plants for a long distance. The structural formula is as follows:
in the prior art, CN101969781B discloses a bactericide compound and a mixture thereof, and specifically discloses the biological activity of a composition containing fluorothiazole pyrimidone and mandipropamid on late blight of tomatoes (late blight of tomatoes) and downy mildew of cucumbers; CN104336024a discloses a bactericidal composition containing fluorothiazole piretanone and amides, and specifically discloses a control effect of fluorothiazole piretanone and mandipropamid for controlling cucumber downy mildew and potato late blight, but no related report exists about the use of mandipropamid and fluorothiazole piretanone in combination for controlling grape downy mildew.
Disclosure of Invention
Based on the above circumstances, the invention aims to provide the application of the sterilizing composition containing mandipropamid and fluorothiazole pyrithione in preventing and controlling grape downy mildew, and the sterilizing composition has good prevention effect on the grape downy mildew caused by the grape monoaxial mold, long lasting period and remarkable synergistic effect, can effectively slow down the generation and development of pathogenic bacteria resistance, and is environment-friendly.
In order to achieve the above purpose, the present invention adopts the following technical scheme: the application of the bactericidal composition containing mandipropamid and fluorothiazole piridon in preventing and controlling grape downy mildew comprises an active ingredient A mandipropamid and an active ingredient B fluorothiazole piridon, wherein the mass ratio of mandipropamid to fluorothiazole piridon is 25:1-2:25;
further, the mass ratio of mandipropamid to oxazopiclone is 25:1, 18:1, 25:2, 10:1, 25:3, 25:6, 16:5, 8:5, 1:1, 16:25, 9:25, 6:25, 3:25, 1:10, 2:25;
further, the mass ratio of the mandipropamid to the fluorothiazole pyrithione is 18:1-1:10;
further, the mass ratio of mandipropamid to oxazopiclone is 18:1, 25:2, 10:1, 25:3, 25:6, 16:5, 8:5, 1:1, 16:25, 9:25, 6:25, 3:25, 1:10;
further, the mass ratio of the mandipropamid to the fluorothiazole pyrithione is 25:2-16:25;
further, the mass ratio of mandipropamid to oxazopiclone is 25:2, 10:1, 25:3, 25:6, 16:5, 8:5, 1:1, 16:25;
further, the mass ratio of mandipropamid to oxazopiclone is 25:3.
Further, the total weight of the bactericidal composition is calculated by 100 weight percent, and the total weight of the active component A and the active component B accounts for 2-70 percent of the total weight of the bactericidal composition;
further, the total weight of the sterilization composition is 5-50% of the total weight of the sterilization composition based on 100 wt%;
further, the bactericidal composition comprises an agriculturally acceptable auxiliary ingredient in addition to the active ingredient, wherein the auxiliary ingredient is selected from one or more of wetting agents, dispersing agents, emulsifying agents, thickening agents, disintegrating agents, antifreezing agents, antifoaming agents, solvents, preservatives, stabilizers, synergists or carriers;
further, the bactericidal composition can be prepared into an agriculturally acceptable preparation formulation, and the preparation formulation is a solid preparation or a liquid preparation;
the solid preparation comprises powder, granules, balls, tablets, strips, wettable powder, oil dispersion powder, emulsion powder, water dispersible granules, emulsion granules, water dispersible tablets, soluble powder, soluble tablets or soluble granules;
the liquid preparation comprises a soluble agent, an oil agent, a spreading oil agent, an emulsifiable concentrate, emulsion, dispersible agent, ointment, aqueous emulsion, oil emulsion, microemulsion, lipid suspending agent, microcapsule suspending agent, oil suspending agent, dispersible oil suspending agent, suspending emulsion, microcapsule suspending-suspending agent, microcapsule suspending-aqueous emulsion or microcapsule suspending-suspending emulsion;
further, the preparation formulation is a liquid preparation, and the liquid preparation is a suspending agent;
further, the grape downy mildew is a disease caused by fungi of the genera flagelliforme, oomycetes, downy mildew, and monoaxial mildew;
further, the uniaxial mould fungus is uniaxial mould viticola (Plasmopara viticola);
further, the fungicidal composition is applied to the pests to be controlled or the medium on which it grows in an effective dose;
the invention has the beneficial effects that:
the invention enhances the bactericidal activity by reasonably compounding mandipropamid and oxathiapiprazole, has good control effect on grape downy mildew caused by grape monoaxial mildew, delays the generation and development of pathogenic bacteria drug resistance, prolongs the lasting effect of the medicament, meets the requirement of pesticide preparation safety under reasonable proportion, and is environment-friendly.
Detailed Description
The present invention will be described in further detail with reference to the following examples in order to make the objects, technical solutions and advantages of the present invention more apparent. It should be understood that the specific embodiments described herein are for purposes of illustration only and are not intended to limit the scope of the invention.
Preparation example:
preparation example 1:22% mandipropamid-Fluozolopyrazone suspension (10:1)
The formula comprises the following components: 20% mandipropamid, 2% fluothiazole ethyl ketone, 2% fatty alcohol polyoxyethylene ether, 3% sodium dodecyl benzene sulfonate, 3% alkylaryl polyoxyethylene ether polyoxypropylene ether, 3% styrol polyoxyethylene ether phosphate, 0.25% xanthan gum, 5% ethylene glycol, 0.2% sodium benzoate, 0.5% silicone oil and deionized water are used for the balance.
The preparation method comprises the following steps: according to the formula proportion, the active ingredients, the surfactant and other functional auxiliary agents are sequentially placed in a reaction kettle, water is added and mixed uniformly, high-speed shearing and wet sanding are carried out, and finally, the suspending agent product is obtained through homogenizing and filtering.
Preparation example 2:28% mandipropamid-fluorothiazole pyrithione suspension (25:3)
The formula comprises the following components: 25% mandipropamid, 3% fluothiazole ethyl ketone, 1% succinic acid ester sulfonate, 3% alkylphenol polyoxyethylene, 2% alkylaryl polyoxyethylene polyoxypropylene ether, 1% naphthalene sulfonate formaldehyde condensate, 0.2% xanthan gum, 1% sodium sorbate, 5% glycerol, 0.5% silicone oil and deionized water, and the balance is made up.
The preparation method comprises the following steps: the same as in preparation example 1.
Preparation example 3:31% mandipropamid-Fluozolopyrazone suspension (25:6)
The formula comprises the following components: 25% mandipropamid, 6% fluothiazole ethyl ketone, 1% isomeric alcohol polyoxyethylene ether, 4% alkylphenol polyoxyethylene ether phosphate, 1% sodium lignin sulfonate, 3% styrol polyoxyethylene ether phosphate, 0.25% xanthan gum, 5% ethylene glycol, 0.1% sodium benzoate, 0.5% silicone oil and deionized water are used for the balance.
The preparation method comprises the following steps: the same as in preparation example 1.
Indoor biological test
Example 1: mandipropamid and fluorothiazole pyrifos compounded indoor biological test for grape downy mildew
Test agent: 95% of fluorothiazole metacetirizine technical and 93% of mandipropamid technical are provided by a group development center.
Test pathogenic bacteria: the grape downy mildew (Plasmopara viticola) is collected from grape test fields of the national academy of agricultural sciences in the tobacco stand, and fresh and typical disease leaves with large leaf back mildew layer quantity are collected for test.
And (3) preparation of a medicament: dissolving the raw materials with a proper solvent, and adding 0.1% Tween 80 to prepare a mother solution. According to the activity of the medicines, preparing the raw medicines into a series of concentration liquid medicines, pouring the liquid medicines into culture dishes with the diameter of 9cm, 20mL of each dish, and setting a treatment which does not contain the medicines and only contains the corresponding solvent as a blank control, wherein each treatment is repeated for 4 times
Preparation of spore suspension: washing with distilled water to remove sporangia on the surface of the disease leaves infected with grape downy mildew, and placing the disease leaves at 25 ℃ for moisturizing for 24 hours to culture fresh spores. After 24 hours, the fresh spores were brushed with a clean brush pen into sterile distilled water to prepare a spore suspension, and the concentration of the sporangium suspension was adjusted to 5X 10 using a microscope and Neubauer blood cell counting plate 5 And (3) one/mL for later use.
Inoculating: the test adopts a leaf disc method, the 4 th to 5 th leaves on the current year disease-free grape branches are selected, a leaf disc with the diameter of 1cm is cut by a puncher, the back surfaces of the leaves are upwards placed on the surface of a culture dish liquid medicine, 15 leaf discs/dish are used, and 20 mu L of sporangium suspension is inoculated in the center of each leaf disc. Culturing in a biological incubator at 25deg.C with humidity of about 80% under illumination for 12 hr/d.
Data statistics and analysis: the disease condition was investigated when the disease of the blank control leaf disk was uniform. The lesions were graded and recorded according to the percentage of lesion area to leaf disk area.
The grape downy mildew classification criteria (in leaf) are:
grade 0, no lesions;
1 grade, the area of the disease spots accounts for less than 5% of the whole leaf area;
stage 3, the area of the lesion accounts for 6% -25% of the whole leaf area;
grade 5, the area of the lesion accounts for 26% -50% of the whole leaf area;
7, the area of the lesion accounts for 51% -75% of the whole leaf area;
grade 9, the area of the disease spots accounts for more than 76% of the whole leaf area.
The disease index is calculated according to the following formula:
the control effect is calculated according to the following formula:
statistical analysis:
analysis is carried out by a DPS statistical analysis system to obtain EC 50 And evaluating the activity of the test agent on the biological test material.
The co-toxicity coefficient (CTC value) of the blend was calculated as follows:
wherein:
ati—actual measured virulence index of the mixture;
S-EC of Standard Agents 50 Milligrams per liter (mg/L);
M-EC of mixture 50 Units are milligrams per liter (mg/L).
TTI＝TI A ×P A +TI B ×P B
Wherein:
TTI-the theoretical toxicity index of the mixture;
TI A -a medicament virulence index;
P A -the percentage of agent a in the mix, in percent (%);
TI B -B agent virulence index;
P B the percentage of the B medicament in the mixture is expressed as percentage (%).
Wherein:
ctc—co-toxicity coefficient;
ati—actual measured virulence index of the mixture;
TTI-the theoretical toxicity index of the mixture.
The compound co-toxicity coefficient CTC is more than or equal to 120 and shows synergistic effect; ctc.ltoreq.80 shows antagonism; 80 < CTC < 120 shows additive effect. The results of the indoor tests are shown in the following table:
TABLE 1 indoor biological assay of Bicetrimide and Fluobupropion complex pair grape downy mildew
As can be seen from the indoor test in Table 1, the single agents of mandipropamid and oxazopyr have higher toxicity to the uniaxial mould of grape, and the EC thereof 50 0.1032mg/L and 3.6128mg/L, respectively.
Mandipropamid and fluorothiazole pyrithione are mixed reasonably to the dextranThe downy mildew has better control effect. The indoor biological measurement result shows that the co-toxicity coefficient of the mandipropamid and the fluorothiazole pyrifos is larger than 120 within the mass ratio of 18:1-1:10, and the combined effect is synergistic. When the mass ratio of mandipropamid to oxazopiclone is 25:3, the EC is that 50 The total toxicity coefficient is 178.588 at 0.0645mg/L, and the synergy is remarkable.
Example 2: indoor bioassay test for cucumber downy mildew by compounding mandipropamid and fluorothiazole ethyl ketone
The test is based on: test reference NY/T1156.7-2006 section 7 of pesticide indoor bioassay test criteria section 7: potted plant method for preventing and controlling cucumber downy mildew.
Test target: cucumber downy mildew (Pseudoperonospora cubensis), supplied by the group center laboratory.
Test instrument equipment: electronic balances, spraying equipment, climatic chambers, biological incubators, petri dishes, pipettors, and the like.
Preparing a test material: and (3) selecting a disease-sensitive cucumber variety potted plant (Xintaimi thorn), and growing seedlings to 4-6 true leaf periods for standby.
Test agent: 95% of the fluozolpidem original drug and 93% of the mandipropamid original drug are provided by a group development center.
According to the indoor bioassay test result of mandipropamid and oxazopiclone in the embodiment 1, the synergistic ratio of the mandipropamid and oxazopiclone to the grape downy mildew is screened to determine the biological activity of mandipropamid and oxazopiclone to the cucumber downy mildew.
The test steps are as follows:
(1) Preparation of sporangia suspension
Selecting infected cucumber leaf, washing with distilled water at 4deg.C to obtain sporangium of Peronosporangium of Peronospora of Fabricius, and preparing into suspension (concentration of 1×10 per ml 5 1X 10 7 The sporocysts) were stored at 4℃until use.
(2) Preparation of medicament
The crude drug is dissolved in a proper solvent and then diluted with 0.1% Tween 80 aqueous solution. According to the activity of the medicament, 5 series of mass concentrations are set.
(3) Medicament treatment
According to the test design, each treatment agent is uniformly sprayed on the two sides of the blade until all the blades are wet, and the blade is ready for use after the liquid medicine is naturally air-dried. The test set-up treatment without agent served as a blank.
(4) Inoculation and culture
Fresh sporangia suspension was spray inoculated on the back of the leaf, 5 pots per treatment, 2 plants per pot, and each treatment was repeated 4 times. Culturing under the conditions that the photoperiod is illumination, darkness=12h:12h, the temperature is 17-22 ℃ and the relative humidity is 92-95 percent after inoculation.
Experimental investigation:
the inoculated leaves were investigated in stages according to the blank disease condition. Each treatment investigated 30 leaves, which were ranked and recorded using the following ranking method:
level 0: no disease;
stage 1: the area of the disease spots accounts for less than 5% of the area of the whole leaf;
3 stages: the area of the disease spots accounts for 6-10% of the area of the whole leaf;
5 stages: the area of the disease spots accounts for 11% -25% of the area of the whole leaf;
7 stages: the area of the disease spots accounts for 26% -50% of the area of the whole leaf;
stage 9: the area of the disease spots accounts for more than 50% of the area of the whole leaf;
and (3) data calculation:
and according to the data survey, calculating the disease index and the prevention and treatment effect of each treatment.
The disease index is calculated according to the following formula:
the control effect is calculated according to the following formula:
statistical analysis:
analysis is carried out by a DPS statistical analysis system to obtain EC 50 And evaluating the activity of the test agent on the biological test material.
The co-toxicity coefficient (CTC value) of the blend was calculated as follows:
wherein:
ati—actual measured virulence index of the mixture;
S-EC of Standard Agents 50 Milligrams per liter (mg/L);
M-EC of mixture 50 Units are milligrams per liter (mg/L).
TTI＝TI A ×P A +TI B ×P B
Wherein:
TTI-the theoretical toxicity index of the mixture;
TI A -a medicament virulence index;
P A -the percentage of agent a in the mix, in percent (%);
TI B -B agent virulence index;
P B the percentage of the B medicament in the mixture is expressed as percentage (%).
Wherein:
ctc—co-toxicity coefficient;
ati—actual measured virulence index of the mixture;
TTI-the theoretical toxicity index of the mixture.
The compound co-toxicity coefficient CTC is more than or equal to 120 and shows synergistic effect; ctc.ltoreq.80 shows antagonism; 80 < CTC < 120 shows additive effect.
The results of the indoor tests are shown in the following table:
TABLE 2 indoor biological assay of Bicetrimide and Fluobupropion for cucumber downy mildew
The indoor test results of the table 2 aiming at the cucumber downy mildew show that the single agents of mandipropamid and the oxazopiclone have better control effect on the cucumber downy mildew, but the mixed agents have different biological activities on the cucumber downy mildew under different proportions. The mass ratio of mandipropamid to oxazopiclone is 16:5, 8:5 and 9:25, the co-toxicity coefficient measured indoors is greater than 120, and the combined effect is shown as synergy; and at other ratios, exhibits additive or antagonistic effects.
Field efficacy test
Example 3: field control test for grape downy mildew by compounding mandipropamid and fluorothiazole ethyl ketone
The test is described in GB/T17980.122-2004 section 122 of the pesticide field efficacy test criterion (II): the bactericide can prevent and treat grape downy mildew.
Test site: experiments were carried out in a bench development area tidal town Liu Guzhuang village grape plantation in 7-9 months 2019, the grape downy mildew of the land occurs throughout the year, the soil is sandy loam, and the management level is moderate.
Test target: grape downy mildew (Plasmopara viticola).
Test crop: grape (Kyoho) with row spacing of 1.0m×1.5m, 6 years tree age, and trellis cultivation.
Test cell setting: test and control agents and blank control cell treatments were arranged in random groups with 12m per cell area 2 8 vines were planted per cell, and each treatment was repeated 4 times.
Drug application method and investigation method: spraying the pesticide at the initial stage of grape downy mildew, and spraying the whole plant with SX-LK16C type manual sprayer with a spraying liquid of 1500L/hm 2 . The entire test was applied 2 consecutive times, 7d intervals.And (3) carrying out disease investigation on 7d after the 1 st medicine and 10d after the 2 nd medicine, randomly selecting 10 new vines which are extracted in the same year in each district during investigation, investigating the total leaf numbers and leaf numbers of all leaves on each branch, and recording the leaf numbers and total leaf numbers of each stage according to the following grading method.
The blade classification method comprises the following steps:
grade 0, no lesions;
1 grade, the area of the disease spots accounts for less than 5% of the whole leaf area;
stage 3, the area of the lesion accounts for 6% -25% of the whole leaf area;
grade 5, the area of the lesion accounts for 26% -50% of the whole leaf area;
7, the area of the lesion accounts for 51% -75% of the whole leaf area;
grade 9, the area of the disease spots accounts for more than 76% of the whole leaf area.
The disease index and the prevention effect are calculated according to the following formula:
the results of the field efficacy test are shown in the following table:
table 3 field control test of mandipropamid and Fluobuprofezin combination on grape downy mildew
The field efficacy results show that 28% of mandipropamid-fluorothiazole-pyrithione (25:3) has better control effect on grape downy mildew, and the control effects of the three treatments are 91.02%, 89.24% and 87.35% respectively.
The tested medicament 28% of mandipropamid-fluorothiazole pyrithione (25:3) has no phytotoxicity to the grape, and no other adverse effect of the tested medicament on test plants is found in the application observation period.
Example 4: field control test of 28% mandipropamid-fluorothiazole pyrithione suspending agent (25:3) on cucumber downy mildew
The test is carried out by referring to GB/T17980.26-2000 pesticide field efficacy test criterion (one) bactericide for controlling cucumber downy mildew.
Test site: the test is carried out on a vegetable base of Yuan Zhuang Zhenguan Zhuang Cun in Wen county of Jining, the test is greenhouse cultivation, the topography is flat, the soil is yellow brown soil, and the soil is fertile. Cucumber is planted throughout the year in the test field, and cucumber downy mildew often occurs. The field cultivation management is consistent with the local cultivation condition.
Test target: cucumber downy mildew (Pseudoperonospora cubensis).
Test crop: cucumber (Xintaimi thorns).
The test method comprises the following steps: the test sets 6 treatments, the stacking groups are arranged, each treatment is repeated for 4 times, and the cell area is 15m 2 Isolation rows are arranged between cells. The test is that when sporadic downy mildew occurs on cucumber leaves, the first application (12 months and 20 days in 2019) is carried out, and a HEMEI brand HM-16A knapsack electric sprayer is adopted to uniformly spray cucumber plants, so that the front and the back of the leaves are uniformly subjected to drug delivery until the cucumber plants are wet during drug delivery. The 2 nd administration was performed 7 days after the interval.
Experimental investigation: because cucumber downy mildew rarely happens sporadically before the first application, the number of pre-drug conditions was not investigated. The control effect was investigated 7d after the first application and 7d after the second application. In the field investigation, a 5-point sampling method is adopted for each cell, 2 plants are investigated at each point, 10 plants are total, and all the leaves are investigated for each plant. The disease sensing area of each leaf is classified according to the percentage of the whole leaf area, the leaf number of each disease is investigated and recorded, and the disease index and the prevention and treatment effect are calculated.
Throughout the test, the safety of each agent treatment on the cucumber was observed at irregular intervals, and no adverse effect of the test agent on the cucumber was found.
The grading method comprises the following steps:
grade 0, no lesions;
1 grade, the area of the disease spots accounts for less than 5% of the whole leaf area;
stage 3, the area of the lesion accounts for 6% -10% of the whole leaf area;
grade 5, the area of the lesion accounts for 11% -25% of the whole leaf area;
7, the area of the lesion accounts for 26-50% of the whole leaf area;
grade 9, the area of the disease spots accounts for more than 51% of the whole leaf area.
The disease index and the prevention effect are calculated according to the following formula:
the results of the field efficacy test are shown in the following table:
table 4 field control test of Bicetrimide and Fluobuprofezin combination on cucumber downy mildew
The field efficacy test results show that the prevention and treatment effect of the mandipropamid and the oxazopiclone compounded according to the mass ratio of 25:3 is not very satisfactory. Investigation 7 days after the second dose found that the duration of the effect was relatively poor.
As can be seen from the indoor combined action test and the field efficacy test, the sterilizing composition containing mandipropamid and oxazopiclone has good control effect on grape downy mildew, can delay the generation and development of pathogenic bacteria drug resistance, and has remarkable lasting effect. The bactericidal composition meets the safety requirement of pesticide preparations, is harmless to target crops and is environment-friendly.
While the invention has been described in detail in terms of the general description and the specific embodiments, it will be apparent to those skilled in the art that various modifications and improvements can be made thereto without departing from the spirit of the invention.
Claims (10)
1. The application of the bactericidal composition containing mandipropamid and oxazomet in preventing and controlling grape downy mildew is characterized in that the bactericidal composition comprises an active ingredient A mandipropamid and an active ingredient B oxazomet, and the mass ratio of mandipropamid to oxazomet is 25:1-2:25.
2. The use according to claim 1, wherein the mass ratio of mandipropamid to fluorothiazole pyrithione is 18:1-1:10.
3. The use according to claim 1, characterized in that the mass ratio of mandipropamid to fluorothiazole pyrithione is 25:2-16:25;
preferably, the mass ratio of the mandipropamid to the oxazoyl pyrrolidone is 25:3.
4. Use according to claim 1, wherein the total weight of the bactericidal composition is 2-70%, preferably 5-50% of the total weight of the bactericidal composition, based on 100wt% of the total weight of the active ingredient a and the active ingredient B.
5. The use according to claim 1, wherein the bactericidal composition comprises, in addition to the active ingredient, agriculturally acceptable auxiliary ingredients selected from one or more of wetting agents, dispersants, emulsifiers, thickeners, disintegrants, freezing point depressants, defoamers, solvents, preservatives, stabilizers, synergists or carriers.
6. The use according to claim 1, wherein the bactericidal composition is formulated as an agriculturally acceptable formulation, said formulation being a solid formulation or a liquid formulation;
the solid preparation comprises powder, granules, balls, tablets, strips, wettable powder, oil dispersion powder, emulsion powder, water dispersible granules, emulsion granules, water dispersible tablets, soluble powder, soluble tablets or soluble granules;
the liquid preparation comprises a soluble agent, an oil agent, a spreading oil agent, an emulsifiable concentrate, emulsion, dispersible agent, ointment, aqueous emulsion, oil emulsion, microemulsion, lipid suspending agent, microcapsule suspending agent, oil suspending agent, dispersible oil suspending agent, suspending emulsion, microcapsule suspending-suspending agent, microcapsule suspending-aqueous emulsion or microcapsule suspending-suspending emulsion.
7. The use of claim 6, wherein the formulation is a liquid formulation and the liquid formulation is a suspension.
8. The use according to claim 1, wherein said grape downy mildew is a disease caused by a fungus of the genus downy mildew of the family downy mildew of the order downy mildew of the phylum dinoflagellata.
9. The use according to claim 8, wherein the uniaxial mould fungus is uniaxial mould viticola (Plasmopara viticola).
10. Use according to any one of claims 1 to 9, wherein the bactericidal composition and/or formulation thereof is applied to a disease or a medium in which growth is to be controlled.
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| CN104336024A (en) * | 2013-08-08 | 2015-02-11 | 陕西美邦农药有限公司 | Bactericidal composition containing fluorothiazolepyrithylone and amides |
Non-Patent Citations (2)
| Title |
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| 寇宏达;韩柳莎;王佳真;陶晡;: "23.4%双炔酰菌胺悬浮剂防治葡萄霜霉病试验", 中国果树, no. 04, 10 July 2013 (2013-07-10), pages 52 - 54 * |
| 王猛;: "氟噻唑吡乙酮防治葡萄霜霉病田间药效试验", 农药科学与管理, vol. 37, no. 05, 15 May 2016 (2016-05-15), pages 47 - 49 * |
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