CN1160090C - Sobering-up composition - Google Patents
Sobering-up composition Download PDFInfo
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- CN1160090C CN1160090C CNB001301675A CN00130167A CN1160090C CN 1160090 C CN1160090 C CN 1160090C CN B001301675 A CNB001301675 A CN B001301675A CN 00130167 A CN00130167 A CN 00130167A CN 1160090 C CN1160090 C CN 1160090C
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Abstract
The present invention discloses a sobering-up composition which comprises (parts by weight) 3 to 80 parts of pueraria root, 1 to 30 parts of liquorice root, 0 to 80 parts of tuckahoe, 0 to 80 parts of polyporus, 5 to 80 parts of jujube, 0 to 0.5 part of tea leaf, 1 to 50 parts of tangerine peel and 0 to 10 parts of honey through extract in water or alcohol and exogenous alcohol dehydrogenase and aldehyde dehydrogenase, wherein the dosage of the alcohol dehydrogenase and the aldehyde dehydrogenase in each gram of the sobering-up composition is 300 to 3000 units. The sobering-up composition can decompose alcohol and acetaldehyde to protect livers.
Description
The invention relates to an anti-alcoholism composition.
Alcohol dehydrogenase can dehydrogenate alcohol to oxidize it to acetaldehyde, which is then converted to acetic acid (acetic acid) by the action of acetaldehyde dehydrogenase, which is a short-chain organic acid beneficial to the body.
Esterase condenses acetic acid and ethanol to produce ethyl acetate, which produces a fragrance.
In the first reaction, the alcohol dehydrogenase and the acetaldehyde dehydrogenase have two sources, exogenous and endogenous, and the exogenous can be obtained by oral food-grade yeast, acetic acid bacteria, lactic acid bacteria and mold; endogenous can stimulate the activity of enzymes in vivo through certain substances, and improve the capacity of the body to degrade alcohol. These substances can be obtained from plants, such as certain amino acids, daidzein, small peptides, daidzein, and acetyl puerarin. These substances can improve the activity of liver P-450 enzyme, alcohol dehydrogenase and acetaldehyde dehydrogenase. (Yangbo, etc.: health food for relieving or neutralizing the effect of alcohol-research on human body efficacy of alcohol-reducing capsule, food industry science and technology 20 (3): 31.1999.)
In the second reaction, the esterase may be derived from acetic acid bacteria, aroma-producing yeast, Candida, etc.
The above is to prevent the damage of alcohol to the body from the biochemical aspect, but it can not completely degrade the alcohol, the rest is still harmful to the body, therefore some liver-protecting and diuresis-promoting substances for preventing the formation of fatty liver, such as food-grade glycyrrhizin and tuckahoe or grifola polysaccharide, etc. are also selected.
Some plant extracts also have anti-hangover effects, such as sobering-up tea (Huhuan IV, application No. 93111667 No. 1084704); a functional health product for relieving alcoholism and strengthening liver and a preparation method thereof (Liu Zheng application No. 96103872 bulletin No. 1164397); a powder for preventing drunkenness and its preparation method (Shuaijie application No. 96115468 bulletin No. 1171247); an anti-intoxication and anti-hangover granule beverage (Torpet et al application No. 96121205 bulletin No. 1181213).
The invention aims to provide an anti-inebriation composition containing microorganisms and plants, which are matched with each other to achieve a better anti-inebriation effect.
The anti-alcohol composition comprises, by weight, 3-80 parts of kudzu roots, 1-30 parts of liquorice, 0-80 parts of poria cocos, 0-80 parts of grifola, 5-80 parts of Chinese dates, 0-0.5 part of tea leaves, 1-50 parts of dried orange peels, 0-10 parts of honey extract extracted by water or alcohol, and exogenous alcohol dehydrogenase and aldehyde dehydrogenase, wherein the dosage of the alcohol dehydrogenase and the aldehyde dehydrogenase in each gram of the composition is 300-.
The plant extract is obtained by extracting with water, alcohol or a water/alcohol mixture by adopting a conventional traditional Chinese medicine extraction method.
In the present invention, the alcohol dehydrogenase is alcohol dehydrogenase or methanol dehydrogenase, and the aldehyde dehydrogenase is acetaldehyde dehydrogenase or formaldehyde dehydrogenase. The alcohol dehydrogenase or aldehyde dehydrogenase is provided by food grade yeast, acetic acid bacteria, lactic acid bacteria and mold. Each gram of crude enzyme thallus contains about 500-2000 units of alcohol dehydrogenase and aldehyde dehydrogenase.
In the invention, the main anti-alcoholiccomponents of the kudzu root extract are puerarin and acetyl puerarin, the main anti-alcoholic component of the licorice root extract is glycyrrhizin, the main anti-alcoholic component of the tuckahoe extract is pachyman, and the main anti-alcoholic component of the polyporus umbellatus extract is pachyman.
In the present invention, these two types of exogenous enzymes can be extracted for use, or microbial cells carrying these enzymes can be directly utilized. The exogenous alcohol dehydrogenase, aldehyde dehydrogenase and physiologically active substances of plants and microorganisms can be used by mixing and producing, or the above active substances can be added into culture medium, fermented by the above microorganisms, and directly orally taken. The alcohol dehydrogenase, aldehyde dehydrogenase and microbial cells carrying these enzymes may be freeze-dried or coated with trehalose for use.
The composition of the invention can be prepared into liquid, powder and capsule, and can comprise pharmaceutically acceptable auxiliary materials. Each of the alcohol dehydrogenase and the aldehyde dehydrogenase is used in an amount of about 1000-10000 units.
The composition of the invention is used for degrading ethanol, methanol, acetaldehyde and formaldehyde in vivo and protecting liver.
The invention adds alcohol dehydrogenase and aldehyde dehydrogenase of microorganism on the basis of Chinese herbal medicine antialcoholism. Experiments prove that the effect of the combination of the two is far greater than that of a single effect.
The composition of the invention consists of two parts: one is that food-grade microorganisms carrying alcohol (containing methanol) dehydrogenase and acetaldehyde (containing formaldehyde) dehydrogenase, such as yeast, acetic acid bacteria, lactic acid bacteria and mold, constitute an exogenous enzyme system. The other is a physiologically active substance which consists of edible and medicinal kudzu root, liquorice, tuckahoe, Chinese date, dried orange peel, tea and honey, the physiologically active substances not only have the function of improving the activity of endogenous alcohol dehydrogenase and aldehyde dehydrogenase of liver, but also have the physiological function of defending the liver from being damaged by alcohol and aldehyde, and the pleasure of drinking is obtained by orally taking the two substances: promoting blood circulation, relieving fatigue, strengthening heart, refreshing, and not (or reducing) physiological dysfunction: headache, vomiting, aphasia, liver injury, etc.
Example 1 culture, preservation and use of acetic acid bacteria.
Strain: acetic acid bacteria (Acetobacter)
Culture medium: slant surface bacteria: 5% glucose, 1% yeast extract, 1% calcium carbonate, natural pH, agar 1.5% liquid medium: 10% 5.6Be wort, 3% 95 ℃ alcohol, 2% calcium carbonate natural pH
And (3) strain culture: culturing at 28-30 deg.C for 24 hr, centrifuging, and collecting thallus
And (3) storage: freezing and storing with 20% malt extract, or adding 6% trehalose into the bacterial sludge, cold drying, and freezing and storing with medical capsule. 0.5 g/capsule for drinking.
Dosage: 3-5 granules
Example 2 culture, preservation and application of Yeast
Strain: yeast: (Sacchromyyces cerevisiae)
Culturing: wort culture medium
And (3) culturing bacteria: aerobic culture at 28 deg.C for 24 hr, and centrifugal collection of thallus
And (3) storage: adding trehalose 6% into the bacterialsludge, cold drying, and making into capsule for administration at a dose of 0.5/g,
dosage: 3-5 granules
EXAMPLE 3 preparation and application of physiologically active substances of plants and microorganisms for both food and drug use
200g of kudzuvine root, 50g of liquorice, 100g of tuckahoe, 50g of Chinese date and 30g of dried orange peel
Cutting into pieces of 1-2 cm in length, adding 3 times of water and 900 units of cellulase (about 2 units/g of raw material), heating to 50 deg.C, maintaining the temperature for 30 min, decocting for 15 min, filtering to obtain extractive solution, decocting with 2 times of water for 15 min, filtering to obtain extractive solution, mixing the two solutions, filtering with filter paper, and concentrating to 500 ml.
The above concentrated solution can be directly sealed and packaged for use, or the concentrated solution can be freeze-dried, pulverized and encapsulated.
Example 4 Mixed fermentation
Strain: yeast, acetic acid bacteria, lactic acid bacteria
Culture medium: 50ml of the concentrate of example 3
Sucrose 5g
Tea leaf 0.5g
Distilled water 50ml
Inoculating bacteria: 3ml of yeast, 2ml of acetic acid bacteria and 2ml of lactic acid bacteria, and standing and culturing for 2-3 days. Packaging into sterile tubes, 100 ml/tube, and storing in refrigerator. It can be taken 100ml before drinking, or taken 100ml during drinking, or freeze-dried, pulverized, and encapsulated. Wherein 100ml contains 500 units of alcohol dehydrogenase and aldehyde dehydrogenase.
EXAMPLE 5 combination of physiologically active substance of Chinese herbal medicine and enzyme Capsule for food and drug use
The powder of example 1 and the powder of example 3 were mixed at a ratio of 1: 1 and encapsulated for further use.
The powder of example 2 and the powder of example 3 were mixed at a ratio of 1: 1 and encapsulated for further use.
Experimental example 1:
40 healthy adult males were selected and randomly divided into a control group and an experimental group, the experimental group was further divided into a plant physiologically active substance group (A, capsule of example 3, 0.5g), a dehydrogenase group (D, capsule of example 1, 0.5g), a plant physiologically active substance + dehydrogenase group (A + D, capsule of example 4, 0.5g), and the control group was administered with 100ml of physiological saline. 1 granule of medical starch capsule. Each group contains 10 people, and each person drinks 150ml of 30% edible alcohol, and takes the medicine during drinking. The method for determining ethanol content comprises collecting venous whole blood, and analyzing ethanol content by gas chromatography. The results of the experiments are shown in the following table.
Influence of exterior anti-hangover agent on ethanol content in blood
| Treatment of | Ethanol content (mg/dl) | |
| Before drinking | 2 hours after drinking | |
| Control group | 1.7±0.54 | 60.8±8.5 |
| Group A | 1.8±0.72 | 48.6±6.5 |
| Group D | 1.7±0.82 | 30.5±5.6 |
| Group A + D | 1.7±0.62 | 20.6±6.8 |
As shown in the table, the anti-hangover effect is sequentially A + D>A compared with the control group.
Claims (3)
1. An anti-alcoholism composition mainly comprises the following active ingredients: 3-80 parts of kudzu root, 1-30 parts of liquorice, more than 0-80 parts of tuckahoe, 5-80 parts of Chinese date, 1-50 parts of dried orange peel extract extracted by water or alcohol, and exogenous alcohol dehydrogenase and aldehyde dehydrogenase, wherein the dosage of the alcohol dehydrogenaseand the aldehyde dehydrogenase in each gram of the composition is 300-3000 units.
2. The composition according to claim 1, wherein the alcohol dehydrogenase is alcohol dehydrogenase or methanol dehydrogenase, and the aldehyde dehydrogenase is acetaldehyde dehydrogenase or formaldehyde dehydrogenase.
3. The composition according to claim 1, wherein the alcohol dehydrogenase or the aldehyde dehydrogenase is a food grade yeast, acetic acid bacterium, lactic acid bacterium or mold fungus.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB001301675A CN1160090C (en) | 2000-10-16 | 2000-10-16 | Sobering-up composition |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB001301675A CN1160090C (en) | 2000-10-16 | 2000-10-16 | Sobering-up composition |
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| Publication Number | Publication Date |
|---|---|
| CN1291499A CN1291499A (en) | 2001-04-18 |
| CN1160090C true CN1160090C (en) | 2004-08-04 |
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| Application Number | Title | Priority Date | Filing Date |
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| CNB001301675A Expired - Fee Related CN1160090C (en) | 2000-10-16 | 2000-10-16 | Sobering-up composition |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2019195592A1 (en) * | 2018-04-04 | 2019-10-10 | The University Of Chicago | Genetically-engineered microbes and compositions thereof |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7662863B2 (en) * | 2003-06-09 | 2010-02-16 | Alan Andrews | Therapeutic agent for the use in reducing alcohol intoxication and reducing or eliminating the negative side effects associated with alcohol ingestion |
| CN102335264A (en) * | 2011-10-09 | 2012-02-01 | 通化师范学院 | Actinidia arguta and kudzuvine root oral liquid for relieving alcoholism, and preparation method thereof |
| CN103271400B (en) * | 2013-05-23 | 2014-08-06 | 苏州谷力生物科技有限公司 | Beverage for sobering up and preparation method thereof |
| CN107789612A (en) * | 2016-08-31 | 2018-03-13 | 李镇坚 | A kind of Chinese medicine fruit complex solid relieve the effect of alcohol sugar and preparation technology |
| CN106318823A (en) * | 2016-11-11 | 2017-01-11 | 杨春季 | Nutritional wine being harmless to liver |
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2000
- 2000-10-16 CN CNB001301675A patent/CN1160090C/en not_active Expired - Fee Related
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2019195592A1 (en) * | 2018-04-04 | 2019-10-10 | The University Of Chicago | Genetically-engineered microbes and compositions thereof |
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| CN1291499A (en) | 2001-04-18 |
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Effective date of registration: 20090227 Address after: No. 82, executive building, Zhichun Road, Beijing, Haidian District 509 Patentee after: Beijing Shenjian Shenzhou Aerospace biology science and Technology Center Address before: No. twelve, No. 303, building B, Zhongguancun, Beijing Patentee before: Guo Xinghua |
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