CN1160090C - Sobering-up composition - Google Patents
Sobering-up composition Download PDFInfo
- Publication number
- CN1160090C CN1160090C CNB001301675A CN00130167A CN1160090C CN 1160090 C CN1160090 C CN 1160090C CN B001301675 A CNB001301675 A CN B001301675A CN 00130167 A CN00130167 A CN 00130167A CN 1160090 C CN1160090 C CN 1160090C
- Authority
- CN
- China
- Prior art keywords
- dehydrogenase
- alcohol
- parts
- composition
- aldehyde
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 239000000203 mixture Substances 0.000 title claims abstract description 17
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 33
- 108010021809 Alcohol dehydrogenase Proteins 0.000 claims abstract description 21
- 102000007698 Alcohol dehydrogenase Human genes 0.000 claims abstract description 21
- 108020002663 Aldehyde Dehydrogenase Proteins 0.000 claims abstract description 17
- 102000005369 Aldehyde Dehydrogenase Human genes 0.000 claims abstract description 17
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 8
- 235000008599 Poria cocos Nutrition 0.000 claims abstract description 7
- 235000001188 Peltandra virginica Nutrition 0.000 claims abstract description 6
- 239000000284 extract Substances 0.000 claims abstract description 6
- 244000248825 Peltandra virginica Species 0.000 claims abstract 2
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 claims description 30
- 241000894006 Bacteria Species 0.000 claims description 18
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 claims description 12
- 240000004808 Saccharomyces cerevisiae Species 0.000 claims description 9
- LPLVUJXQOOQHMX-QWBHMCJMSA-N glycyrrhizinic acid Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@H](O[C@@H]1O[C@@H]1C([C@H]2[C@]([C@@H]3[C@@]([C@@]4(CC[C@@]5(C)CC[C@@](C)(C[C@H]5C4=CC3=O)C(O)=O)C)(C)CC2)(C)CC1)(C)C)C(O)=O)[C@@H]1O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]1O LPLVUJXQOOQHMX-QWBHMCJMSA-N 0.000 claims description 6
- 239000004310 lactic acid Substances 0.000 claims description 6
- 235000014655 lactic acid Nutrition 0.000 claims description 6
- 244000046146 Pueraria lobata Species 0.000 claims description 5
- 235000010575 Pueraria lobata Nutrition 0.000 claims description 5
- 108010081577 aldehyde dehydrogenase (NAD(P)+) Proteins 0.000 claims description 5
- 235000013305 food Nutrition 0.000 claims description 5
- 208000007848 Alcoholism Diseases 0.000 claims description 4
- 244000303040 Glycyrrhiza glabra Species 0.000 claims description 4
- 235000006200 Glycyrrhiza glabra Nutrition 0.000 claims description 4
- 235000006545 Ziziphus mauritiana Nutrition 0.000 claims description 4
- 235000008529 Ziziphus vulgaris Nutrition 0.000 claims description 4
- 201000007930 alcohol dependence Diseases 0.000 claims description 4
- 235000011477 liquorice Nutrition 0.000 claims description 4
- 244000126002 Ziziphus vulgaris Species 0.000 claims description 3
- 102100039702 Alcohol dehydrogenase class-3 Human genes 0.000 claims description 2
- 108010048916 alcohol dehydrogenase (acceptor) Proteins 0.000 claims description 2
- 108010051015 glutathione-independent formaldehyde dehydrogenase Proteins 0.000 claims description 2
- 241000233866 Fungi Species 0.000 claims 1
- 239000004480 active ingredient Substances 0.000 claims 1
- IKHGUXGNUITLKF-UHFFFAOYSA-N Acetaldehyde Chemical compound CC=O IKHGUXGNUITLKF-UHFFFAOYSA-N 0.000 abstract description 6
- 210000004185 liver Anatomy 0.000 abstract description 6
- 244000269722 Thea sinensis Species 0.000 abstract description 4
- 235000012907 honey Nutrition 0.000 abstract description 3
- 241000675108 Citrus tangerina Species 0.000 abstract 1
- 235000018142 Hedysarum alpinum var americanum Nutrition 0.000 abstract 1
- 240000006461 Hedysarum alpinum var. americanum Species 0.000 abstract 1
- 241000222640 Polyporus Species 0.000 abstract 1
- 241000219780 Pueraria Species 0.000 abstract 1
- 240000008866 Ziziphus nummularia Species 0.000 abstract 1
- 239000002775 capsule Substances 0.000 description 10
- 239000013543 active substance Substances 0.000 description 8
- 102000004190 Enzymes Human genes 0.000 description 7
- 108090000790 Enzymes Proteins 0.000 description 7
- 230000035622 drinking Effects 0.000 description 7
- 230000000694 effects Effects 0.000 description 7
- 229940088598 enzyme Drugs 0.000 description 7
- 241000196324 Embryophyta Species 0.000 description 6
- WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 description 6
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 6
- 244000005700 microbiome Species 0.000 description 6
- 239000000843 powder Substances 0.000 description 6
- 244000197580 Poria cocos Species 0.000 description 5
- 239000000243 solution Substances 0.000 description 5
- 239000000126 substance Substances 0.000 description 5
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 4
- 101710088194 Dehydrogenase Proteins 0.000 description 4
- 206010019133 Hangover Diseases 0.000 description 4
- 230000002075 anti-alcohol Effects 0.000 description 4
- 238000012258 culturing Methods 0.000 description 4
- ZQSIJRDFPHDXIC-UHFFFAOYSA-N daidzein Chemical compound C1=CC(O)=CC=C1C1=COC2=CC(O)=CC=C2C1=O ZQSIJRDFPHDXIC-UHFFFAOYSA-N 0.000 description 4
- 239000003814 drug Substances 0.000 description 4
- 239000008187 granular material Substances 0.000 description 4
- 239000001963 growth medium Substances 0.000 description 4
- HDTRYLNUVZCQOY-UHFFFAOYSA-N α-D-glucopyranosyl-α-D-glucopyranoside Natural products OC1C(O)C(O)C(CO)OC1OC1C(O)C(O)C(O)C(CO)O1 HDTRYLNUVZCQOY-UHFFFAOYSA-N 0.000 description 3
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 3
- RXUWDKBZZLIASQ-UHFFFAOYSA-N Puerarin Natural products OCC1OC(Oc2c(O)cc(O)c3C(=O)C(=COc23)c4ccc(O)cc4)C(O)C(O)C1O RXUWDKBZZLIASQ-UHFFFAOYSA-N 0.000 description 3
- HDTRYLNUVZCQOY-WSWWMNSNSA-N Trehalose Natural products O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-WSWWMNSNSA-N 0.000 description 3
- -1 acetyl puerarin Chemical compound 0.000 description 3
- HDTRYLNUVZCQOY-LIZSDCNHSA-N alpha,alpha-trehalose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-LIZSDCNHSA-N 0.000 description 3
- 238000001914 filtration Methods 0.000 description 3
- 238000002360 preparation method Methods 0.000 description 3
- 108090000371 Esterases Proteins 0.000 description 2
- 239000004378 Glycyrrhizin Substances 0.000 description 2
- 241000222684 Grifola Species 0.000 description 2
- 239000008280 blood Substances 0.000 description 2
- 210000004369 blood Anatomy 0.000 description 2
- 229910000019 calcium carbonate Inorganic materials 0.000 description 2
- 235000007240 daidzein Nutrition 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 238000001035 drying Methods 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- 238000007710 freezing Methods 0.000 description 2
- 230000008014 freezing Effects 0.000 description 2
- LPLVUJXQOOQHMX-UHFFFAOYSA-N glycyrrhetinic acid glycoside Natural products C1CC(C2C(C3(CCC4(C)CCC(C)(CC4C3=CC2=O)C(O)=O)C)(C)CC2)(C)C2C(C)(C)C1OC1OC(C(O)=O)C(O)C(O)C1OC1OC(C(O)=O)C(O)C(O)C1O LPLVUJXQOOQHMX-UHFFFAOYSA-N 0.000 description 2
- 229960004949 glycyrrhizic acid Drugs 0.000 description 2
- UYRUBYNTXSDKQT-UHFFFAOYSA-N glycyrrhizic acid Natural products CC1(C)C(CCC2(C)C1CCC3(C)C2C(=O)C=C4C5CC(C)(CCC5(C)CCC34C)C(=O)O)OC6OC(C(O)C(O)C6OC7OC(O)C(O)C(O)C7C(=O)O)C(=O)O UYRUBYNTXSDKQT-UHFFFAOYSA-N 0.000 description 2
- 235000019410 glycyrrhizin Nutrition 0.000 description 2
- 241000411851 herbal medicine Species 0.000 description 2
- 238000001727 in vivo Methods 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 230000000813 microbial effect Effects 0.000 description 2
- 238000002156 mixing Methods 0.000 description 2
- 239000000419 plant extract Substances 0.000 description 2
- 238000004321 preservation Methods 0.000 description 2
- 238000003860 storage Methods 0.000 description 2
- 238000005728 strengthening Methods 0.000 description 2
- 241000589220 Acetobacter Species 0.000 description 1
- 229920001817 Agar Polymers 0.000 description 1
- 241000222120 Candida <Saccharomycetales> Species 0.000 description 1
- 108010059892 Cellulase Proteins 0.000 description 1
- 102000002004 Cytochrome P-450 Enzyme System Human genes 0.000 description 1
- 108010015742 Cytochrome P-450 Enzyme System Proteins 0.000 description 1
- 208000004930 Fatty Liver Diseases 0.000 description 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
- 206010019233 Headaches Diseases 0.000 description 1
- 206010019708 Hepatic steatosis Diseases 0.000 description 1
- 206010067125 Liver injury Diseases 0.000 description 1
- 244000171085 Polyporus umbellatus Species 0.000 description 1
- 235000004837 Polyporus umbellatus Nutrition 0.000 description 1
- 208000004880 Polyuria Diseases 0.000 description 1
- 229920002472 Starch Polymers 0.000 description 1
- 229930006000 Sucrose Natural products 0.000 description 1
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 1
- 206010047700 Vomiting Diseases 0.000 description 1
- 240000000038 Ziziphus mauritiana Species 0.000 description 1
- IKHGUXGNUITLKF-XPULMUKRSA-N acetaldehyde Chemical compound [14CH]([14CH3])=O IKHGUXGNUITLKF-XPULMUKRSA-N 0.000 description 1
- YBCVMFKXIKNREZ-UHFFFAOYSA-N acoh acetic acid Chemical compound CC(O)=O.CC(O)=O YBCVMFKXIKNREZ-UHFFFAOYSA-N 0.000 description 1
- 239000008272 agar Substances 0.000 description 1
- 150000001299 aldehydes Chemical class 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- 201000007201 aphasia Diseases 0.000 description 1
- 230000001580 bacterial effect Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 235000013361 beverage Nutrition 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 230000017531 blood circulation Effects 0.000 description 1
- 229940041514 candida albicans extract Drugs 0.000 description 1
- 229940106157 cellulase Drugs 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 239000012141 concentrate Substances 0.000 description 1
- 238000005520 cutting process Methods 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 230000000593 degrading effect Effects 0.000 description 1
- 239000012153 distilled water Substances 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- 208000010706 fatty liver disease Diseases 0.000 description 1
- 238000000855 fermentation Methods 0.000 description 1
- 230000004151 fermentation Effects 0.000 description 1
- 239000003205 fragrance Substances 0.000 description 1
- 238000004817 gas chromatography Methods 0.000 description 1
- 239000008103 glucose Substances 0.000 description 1
- 150000004676 glycans Chemical class 0.000 description 1
- 239000001649 glycyrrhiza glabra l. absolute Substances 0.000 description 1
- 231100000869 headache Toxicity 0.000 description 1
- 235000013402 health food Nutrition 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 231100000753 hepatic injury Toxicity 0.000 description 1
- 229940051810 licorice root extract Drugs 0.000 description 1
- 235000020725 licorice root extract Nutrition 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 239000002609 medium Substances 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 230000003472 neutralizing effect Effects 0.000 description 1
- 150000007524 organic acids Chemical class 0.000 description 1
- 238000004806 packaging method and process Methods 0.000 description 1
- 230000007084 physiological dysfunction Effects 0.000 description 1
- 230000035790 physiological processes and functions Effects 0.000 description 1
- 239000002504 physiological saline solution Substances 0.000 description 1
- 229920001282 polysaccharide Polymers 0.000 description 1
- 239000005017 polysaccharide Substances 0.000 description 1
- 102000004196 processed proteins & peptides Human genes 0.000 description 1
- 108090000765 processed proteins & peptides Proteins 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- HKEAFJYKMMKDOR-VPRICQMDSA-N puerarin Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1C1=C(O)C=CC(C2=O)=C1OC=C2C1=CC=C(O)C=C1 HKEAFJYKMMKDOR-VPRICQMDSA-N 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 239000010802 sludge Substances 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 231100000240 steatosis hepatitis Toxicity 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- 230000008673 vomiting Effects 0.000 description 1
- 239000012138 yeast extract Substances 0.000 description 1
Landscapes
- Medicines Containing Plant Substances (AREA)
- Medicinal Preparation (AREA)
Abstract
The present invention discloses a sobering-up composition which comprises (parts by weight) 3 to 80 parts of pueraria root, 1 to 30 parts of liquorice root, 0 to 80 parts of tuckahoe, 0 to 80 parts of polyporus, 5 to 80 parts of jujube, 0 to 0.5 part of tea leaf, 1 to 50 parts of tangerine peel and 0 to 10 parts of honey through extract in water or alcohol and exogenous alcohol dehydrogenase and aldehyde dehydrogenase, wherein the dosage of the alcohol dehydrogenase and the aldehyde dehydrogenase in each gram of the sobering-up composition is 300 to 3000 units. The sobering-up composition can decompose alcohol and acetaldehyde to protect livers.
Description
The invention relates to an anti-alcoholism composition.
Alcohol dehydrogenase can dehydrogenate alcohol to oxidize it to acetaldehyde, which is then converted to acetic acid (acetic acid) by the action of acetaldehyde dehydrogenase, which is a short-chain organic acid beneficial to the body.
Esterase condenses acetic acid and ethanol to produce ethyl acetate, which produces a fragrance.
In the first reaction, the alcohol dehydrogenase and the acetaldehyde dehydrogenase have two sources, exogenous and endogenous, and the exogenous can be obtained by oral food-grade yeast, acetic acid bacteria, lactic acid bacteria and mold; endogenous can stimulate the activity of enzymes in vivo through certain substances, and improve the capacity of the body to degrade alcohol. These substances can be obtained from plants, such as certain amino acids, daidzein, small peptides, daidzein, and acetyl puerarin. These substances can improve the activity of liver P-450 enzyme, alcohol dehydrogenase and acetaldehyde dehydrogenase. (Yangbo, etc.: health food for relieving or neutralizing the effect of alcohol-research on human body efficacy of alcohol-reducing capsule, food industry science and technology 20 (3): 31.1999.)
In the second reaction, the esterase may be derived from acetic acid bacteria, aroma-producing yeast, Candida, etc.
The above is to prevent the damage of alcohol to the body from the biochemical aspect, but it can not completely degrade the alcohol, the rest is still harmful to the body, therefore some liver-protecting and diuresis-promoting substances for preventing the formation of fatty liver, such as food-grade glycyrrhizin and tuckahoe or grifola polysaccharide, etc. are also selected.
Some plant extracts also have anti-hangover effects, such as sobering-up tea (Huhuan IV, application No. 93111667 No. 1084704); a functional health product for relieving alcoholism and strengthening liver and a preparation method thereof (Liu Zheng application No. 96103872 bulletin No. 1164397); a powder for preventing drunkenness and its preparation method (Shuaijie application No. 96115468 bulletin No. 1171247); an anti-intoxication and anti-hangover granule beverage (Torpet et al application No. 96121205 bulletin No. 1181213).
The invention aims to provide an anti-inebriation composition containing microorganisms and plants, which are matched with each other to achieve a better anti-inebriation effect.
The anti-alcohol composition comprises, by weight, 3-80 parts of kudzu roots, 1-30 parts of liquorice, 0-80 parts of poria cocos, 0-80 parts of grifola, 5-80 parts of Chinese dates, 0-0.5 part of tea leaves, 1-50 parts of dried orange peels, 0-10 parts of honey extract extracted by water or alcohol, and exogenous alcohol dehydrogenase and aldehyde dehydrogenase, wherein the dosage of the alcohol dehydrogenase and the aldehyde dehydrogenase in each gram of the composition is 300-.
The plant extract is obtained by extracting with water, alcohol or a water/alcohol mixture by adopting a conventional traditional Chinese medicine extraction method.
In the present invention, the alcohol dehydrogenase is alcohol dehydrogenase or methanol dehydrogenase, and the aldehyde dehydrogenase is acetaldehyde dehydrogenase or formaldehyde dehydrogenase. The alcohol dehydrogenase or aldehyde dehydrogenase is provided by food grade yeast, acetic acid bacteria, lactic acid bacteria and mold. Each gram of crude enzyme thallus contains about 500-2000 units of alcohol dehydrogenase and aldehyde dehydrogenase.
In the invention, the main anti-alcoholiccomponents of the kudzu root extract are puerarin and acetyl puerarin, the main anti-alcoholic component of the licorice root extract is glycyrrhizin, the main anti-alcoholic component of the tuckahoe extract is pachyman, and the main anti-alcoholic component of the polyporus umbellatus extract is pachyman.
In the present invention, these two types of exogenous enzymes can be extracted for use, or microbial cells carrying these enzymes can be directly utilized. The exogenous alcohol dehydrogenase, aldehyde dehydrogenase and physiologically active substances of plants and microorganisms can be used by mixing and producing, or the above active substances can be added into culture medium, fermented by the above microorganisms, and directly orally taken. The alcohol dehydrogenase, aldehyde dehydrogenase and microbial cells carrying these enzymes may be freeze-dried or coated with trehalose for use.
The composition of the invention can be prepared into liquid, powder and capsule, and can comprise pharmaceutically acceptable auxiliary materials. Each of the alcohol dehydrogenase and the aldehyde dehydrogenase is used in an amount of about 1000-10000 units.
The composition of the invention is used for degrading ethanol, methanol, acetaldehyde and formaldehyde in vivo and protecting liver.
The invention adds alcohol dehydrogenase and aldehyde dehydrogenase of microorganism on the basis of Chinese herbal medicine antialcoholism. Experiments prove that the effect of the combination of the two is far greater than that of a single effect.
The composition of the invention consists of two parts: one is that food-grade microorganisms carrying alcohol (containing methanol) dehydrogenase and acetaldehyde (containing formaldehyde) dehydrogenase, such as yeast, acetic acid bacteria, lactic acid bacteria and mold, constitute an exogenous enzyme system. The other is a physiologically active substance which consists of edible and medicinal kudzu root, liquorice, tuckahoe, Chinese date, dried orange peel, tea and honey, the physiologically active substances not only have the function of improving the activity of endogenous alcohol dehydrogenase and aldehyde dehydrogenase of liver, but also have the physiological function of defending the liver from being damaged by alcohol and aldehyde, and the pleasure of drinking is obtained by orally taking the two substances: promoting blood circulation, relieving fatigue, strengthening heart, refreshing, and not (or reducing) physiological dysfunction: headache, vomiting, aphasia, liver injury, etc.
Example 1 culture, preservation and use of acetic acid bacteria.
Strain: acetic acid bacteria (Acetobacter)
Culture medium: slant surface bacteria: 5% glucose, 1% yeast extract, 1% calcium carbonate, natural pH, agar 1.5% liquid medium: 10% 5.6Be wort, 3% 95 ℃ alcohol, 2% calcium carbonate natural pH
And (3) strain culture: culturing at 28-30 deg.C for 24 hr, centrifuging, and collecting thallus
And (3) storage: freezing and storing with 20% malt extract, or adding 6% trehalose into the bacterial sludge, cold drying, and freezing and storing with medical capsule. 0.5 g/capsule for drinking.
Dosage: 3-5 granules
Example 2 culture, preservation and application of Yeast
Strain: yeast: (Sacchromyyces cerevisiae)
Culturing: wort culture medium
And (3) culturing bacteria: aerobic culture at 28 deg.C for 24 hr, and centrifugal collection of thallus
And (3) storage: adding trehalose 6% into the bacterialsludge, cold drying, and making into capsule for administration at a dose of 0.5/g,
dosage: 3-5 granules
EXAMPLE 3 preparation and application of physiologically active substances of plants and microorganisms for both food and drug use
200g of kudzuvine root, 50g of liquorice, 100g of tuckahoe, 50g of Chinese date and 30g of dried orange peel
Cutting into pieces of 1-2 cm in length, adding 3 times of water and 900 units of cellulase (about 2 units/g of raw material), heating to 50 deg.C, maintaining the temperature for 30 min, decocting for 15 min, filtering to obtain extractive solution, decocting with 2 times of water for 15 min, filtering to obtain extractive solution, mixing the two solutions, filtering with filter paper, and concentrating to 500 ml.
The above concentrated solution can be directly sealed and packaged for use, or the concentrated solution can be freeze-dried, pulverized and encapsulated.
Example 4 Mixed fermentation
Strain: yeast, acetic acid bacteria, lactic acid bacteria
Culture medium: 50ml of the concentrate of example 3
Sucrose 5g
Tea leaf 0.5g
Distilled water 50ml
Inoculating bacteria: 3ml of yeast, 2ml of acetic acid bacteria and 2ml of lactic acid bacteria, and standing and culturing for 2-3 days. Packaging into sterile tubes, 100 ml/tube, and storing in refrigerator. It can be taken 100ml before drinking, or taken 100ml during drinking, or freeze-dried, pulverized, and encapsulated. Wherein 100ml contains 500 units of alcohol dehydrogenase and aldehyde dehydrogenase.
EXAMPLE 5 combination of physiologically active substance of Chinese herbal medicine and enzyme Capsule for food and drug use
The powder of example 1 and the powder of example 3 were mixed at a ratio of 1: 1 and encapsulated for further use.
The powder of example 2 and the powder of example 3 were mixed at a ratio of 1: 1 and encapsulated for further use.
Experimental example 1:
40 healthy adult males were selected and randomly divided into a control group and an experimental group, the experimental group was further divided into a plant physiologically active substance group (A, capsule of example 3, 0.5g), a dehydrogenase group (D, capsule of example 1, 0.5g), a plant physiologically active substance + dehydrogenase group (A + D, capsule of example 4, 0.5g), and the control group was administered with 100ml of physiological saline. 1 granule of medical starch capsule. Each group contains 10 people, and each person drinks 150ml of 30% edible alcohol, and takes the medicine during drinking. The method for determining ethanol content comprises collecting venous whole blood, and analyzing ethanol content by gas chromatography. The results of the experiments are shown in the following table.
Influence of exterior anti-hangover agent on ethanol content in blood
| Treatment of | Ethanol content (mg/dl) | |
| Before drinking | 2 hours after drinking | |
| Control group | 1.7±0.54 | 60.8±8.5 |
| Group A | 1.8±0.72 | 48.6±6.5 |
| Group D | 1.7±0.82 | 30.5±5.6 |
| Group A + D | 1.7±0.62 | 20.6±6.8 |
As shown in the table, the anti-hangover effect is sequentially A + D>A compared with the control group.
Claims (3)
1. An anti-alcoholism composition mainly comprises the following active ingredients: 3-80 parts of kudzu root, 1-30 parts of liquorice, more than 0-80 parts of tuckahoe, 5-80 parts of Chinese date, 1-50 parts of dried orange peel extract extracted by water or alcohol, and exogenous alcohol dehydrogenase and aldehyde dehydrogenase, wherein the dosage of the alcohol dehydrogenaseand the aldehyde dehydrogenase in each gram of the composition is 300-3000 units.
2. The composition according to claim 1, wherein the alcohol dehydrogenase is alcohol dehydrogenase or methanol dehydrogenase, and the aldehyde dehydrogenase is acetaldehyde dehydrogenase or formaldehyde dehydrogenase.
3. The composition according to claim 1, wherein the alcohol dehydrogenase or the aldehyde dehydrogenase is a food grade yeast, acetic acid bacterium, lactic acid bacterium or mold fungus.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB001301675A CN1160090C (en) | 2000-10-16 | 2000-10-16 | Sobering-up composition |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB001301675A CN1160090C (en) | 2000-10-16 | 2000-10-16 | Sobering-up composition |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1291499A CN1291499A (en) | 2001-04-18 |
| CN1160090C true CN1160090C (en) | 2004-08-04 |
Family
ID=4594007
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNB001301675A Expired - Fee Related CN1160090C (en) | 2000-10-16 | 2000-10-16 | Sobering-up composition |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1160090C (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2019195592A1 (en) * | 2018-04-04 | 2019-10-10 | The University Of Chicago | Genetically-engineered microbes and compositions thereof |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7662863B2 (en) * | 2003-06-09 | 2010-02-16 | Alan Andrews | Therapeutic agent for the use in reducing alcohol intoxication and reducing or eliminating the negative side effects associated with alcohol ingestion |
| CN102335264A (en) * | 2011-10-09 | 2012-02-01 | 通化师范学院 | Actinidia arguta and kudzuvine root oral liquid for relieving alcoholism, and preparation method thereof |
| CN103271400B (en) * | 2013-05-23 | 2014-08-06 | 苏州谷力生物科技有限公司 | Beverage for sobering up and preparation method thereof |
| CN107789612A (en) * | 2016-08-31 | 2018-03-13 | 李镇坚 | A kind of Chinese medicine fruit complex solid relieve the effect of alcohol sugar and preparation technology |
| CN106318823A (en) * | 2016-11-11 | 2017-01-11 | 杨春季 | Nutritional wine being harmless to liver |
-
2000
- 2000-10-16 CN CNB001301675A patent/CN1160090C/en not_active Expired - Fee Related
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2019195592A1 (en) * | 2018-04-04 | 2019-10-10 | The University Of Chicago | Genetically-engineered microbes and compositions thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| CN1291499A (en) | 2001-04-18 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US8257761B2 (en) | Polyphenol-containing products | |
| CN103976052A (en) | Fermentation tea juice and preparation method thereof | |
| CN112999261B (en) | Natto fermented composition capable of relieving arteriosclerosis and preparation method and application thereof | |
| CN114304335B (en) | Method for fermenting and enriching active ingredients of dendrobium leaves and application of method | |
| KR100787633B1 (en) | Tea and Tea Manufacturing Method for Improving Liver Function and Curing of Hangover | |
| KR100748846B1 (en) | Preparation method of fermented propolis | |
| CN111955721A (en) | Gastrodia elata edible fungus flavor polyphenol liquid plant enzyme formula and preparation method thereof | |
| CN1160090C (en) | Sobering-up composition | |
| CN105368695A (en) | Fermented vinegar with poria cocos and propolis and method for manufacturing fermented vinegar | |
| KR20160055292A (en) | MANUFACTURE OF FERMENTED Allium hookeri FROM YEASTS AND NATURAL ENZYME AND PREPARATION OF COMBINED BEVERAGE FOR QUENCHING THIRST | |
| CN116463183A (en) | Tartary buckwheat health wine blended with pleurotus eryngii and preparation method thereof | |
| JP2012017337A (en) | Composition for alcohol metabolism promotion | |
| CN111728201B (en) | Lucid ganoderma ferment as well as preparation method and application thereof | |
| KR20090043758A (en) | Composition for improvement of fatty liver | |
| KR100624101B1 (en) | Composition for enhancing alcohol decomposition containing extract from hericicum erinaceus | |
| KR101228554B1 (en) | The Fermentation Forming Method of Citrus Sunki And The Product thereof | |
| CN110093290A (en) | It is a kind of based on brewing functional direction lactobacillus acetotolerans distilled spirit with sesame flavour production in application | |
| CN111728200B (en) | Cordyceps sinensis ferment as well as preparation method and application thereof | |
| KR20160012705A (en) | Method for preparing natural fermented vinegar using dendropanax morbiferum leveille and pear | |
| KR102585372B1 (en) | Composition for relieving hangover containing ginseng fermented extract, Gamoderma Lucidum mycelium culture supernatant and Trametes versicolor mycelium culture supernatant as an active ingredient | |
| KR20200016610A (en) | Composition for Improvement of Fatty Liver | |
| CN116726150B (en) | Lactic acid bacteria freeze-dried powder containing acetaldehyde dehydrogenase and preparation method and application thereof | |
| CN107801987A (en) | A kind of truffle and pseudo-ginseng are mycoplasma of raw material and preparation method thereof | |
| CN115491280A (en) | Roxburgh rose enzymatic fruit vinegar and preparation process and application thereof | |
| CN106668081B (en) | High-activity drying method of golden ganoderma medicinal material |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C06 | Publication | ||
| PB01 | Publication | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| C41 | Transfer of patent application or patent right or utility model | ||
| TR01 | Transfer of patent right |
Effective date of registration: 20090227 Address after: No. 82, executive building, Zhichun Road, Beijing, Haidian District 509 Patentee after: Beijing Shenjian Shenzhou Aerospace biology science and Technology Center Address before: No. twelve, No. 303, building B, Zhongguancun, Beijing Patentee before: Guo Xinghua |
|
| ASS | Succession or assignment of patent right |
Owner name: BEIJING SHENJIAN SHENZHOU AEROSPACE BIO-TECHNOLOGY Free format text: FORMER OWNER: GUO XINGHUA Effective date: 20090227 |
|
| ASS | Succession or assignment of patent right |
Owner name: SHENJIAN SHENZHOU (BEIJING) AEROSPACE BIOTECHNOLOG Free format text: FORMER OWNER: BEIJING SHENJIAN SHENZHOU AEROSPACE BIOTECHNOLOGY CENTRE Effective date: 20100414 |
|
| C41 | Transfer of patent application or patent right or utility model | ||
| COR | Change of bibliographic data |
Free format text: CORRECT: ADDRESS; FROM: 100086 509, ADMINISTRATION BUILDING, NO. 82, ZHICHUN ROAD, HAIDIAN DISTRICT, BEIJING CITY TO: 100086 509, ADMINISTRATION BUILDING, NO.82, ZHICHUN ROAD, HAIDIAN DISTRICT |
|
| TR01 | Transfer of patent right |
Effective date of registration: 20100414 Address after: 100086 executive building, No. 82, Haidian District, Zhichun Road 509 Patentee after: Arrows Shenzhou (Beijing) Biotechnology Co. Ltd. Address before: 100086, executive building, No. 82, Haidian District, Beijing, 509, Zhichun Road Patentee before: Beijing Shenjian Shenzhou Aerospace biology science and Technology Center |
|
| DD01 | Delivery of document by public notice |
Addressee: Arrows Shenzhou (Beijing) Biotechnology Co. Ltd. Document name: Notification to Pay the Fees |
|
| DD01 | Delivery of document by public notice |
Addressee: Wu Qianjin Document name: Notification of Termination of Patent Right |
|
| C17 | Cessation of patent right | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20040804 Termination date: 20131016 |