CN116002151A

CN116002151A - Non-terminal sterilized large transfusion soft bag production process

Info

Publication number: CN116002151A
Application number: CN202211619262.7A
Authority: CN
Inventors: 霍本洪; 赵志强
Original assignee: Truking Technology Ltd
Current assignee: Truking Technology Ltd
Priority date: 2022-12-14
Filing date: 2022-12-14
Publication date: 2023-04-25

Abstract

A non-terminally sterilized large transfusion soft bag production process, comprising the steps of: s1, preparing a sealed soft bag, wherein the soft bag comprises a bag body and a mouth tube connected with the bag body, and a sealing element for sealing is arranged on at least one mouth tube; s2, sterilizing the soft bag; s3, removing the sealing piece on the mouth tube; s4, filling through a mouth tube; s5, sealing the mouth tube by using the cover body. The method comprises the steps of firstly arranging a removable sealing element on the mouth tube to temporarily seal the mouth tube, then sterilizing, removing the sealing element after sterilization is completed, and filling the mouth tube in an open state, so that the mouth tube can be filled, and sealing the mouth tube by using a cover body after filling is completed to prepare a large infusion soft bag product which is not subjected to final sterilization; the bag body is not required to be cut into an opening and filled from the opening, the problem that the bag opening success rate is low or the bag is manufactured by adopting an expensive powder-liquid multi-chamber bag infusion film is avoided, the deformation of the bag body in the sterilization process can not influence the subsequent filling through the mouth tube, and therefore, the empty bag can be loaded normally during sterilization.

Description

Non-terminal sterilized large transfusion soft bag production process

Technical Field

The invention relates to the technical field of food and medicine packaging methods, in particular to a non-terminal sterilization production process of a large transfusion soft bag.

Background

Most of the production processes of the non-PVC film large transfusion soft bag adopt a final sterilization process, namely, the large transfusion soft bag is firstly manufactured by a bag making filling and sealing machine, and then the final sterile product is manufactured by water bath or steam high-temperature sterilization which are commonly adopted at present. However, some liquid medicines cannot withstand the high-temperature sterilization process, so that the empty bags are required to be sterilized first, and then the liquid medicines are subjected to aseptic filling and sealing to prepare large transfusion soft bag products which are not subjected to final sterilization. The prior art adopts the steps that the mouth tube and the combined cover are made into a whole, then the mouth tube and the non-PVC infusion film are made into a sealed empty bag through a bag making machine, and the sealed empty bag is sterilized at high temperature and then is subjected to aseptic filling and sealing of liquid medicine through a tail filling and sealing machine. The sterilization loading form of the empty bag is complex, the empty bag is required to be completely positioned, the deformation of the bag body in the sterilization process is avoided to influence the subsequent tail filling, meanwhile, the form of forming an opening by cutting the tail is complex and unstable, the bag opening success rate is low, the sealing qualification rate is low due to the influence of liquid medicine on the tail after filling, the process equipment structure is complex, the productivity is low, and the production and manufacturing cost is greatly increased. If the powder-liquid multi-chamber bag is used for making the bag by using the liquid-conveying film, the bag opening success rate is relatively high, but the material price is high, and the production cost is greatly increased.

Disclosure of Invention

The invention aims to overcome the defects of the prior art, and provides a non-terminal sterilization large transfusion soft bag production process which has good feasibility, can realize continuous and stable production in a large batch, is beneficial to improving the qualification rate and the productivity and reducing the use cost of packaging materials.

In order to solve the technical problems, the invention adopts the following technical scheme:

a non-terminally sterilized large transfusion soft bag production process, which comprises the following steps:

s1, preparing a sealed soft bag, wherein the soft bag comprises a bag body and a mouth tube connected with the bag body, and a sealing element for sealing is arranged on at least one mouth tube;

s2, sterilizing the soft bag;

s3, removing the sealing piece on the mouth tube;

s4, filling through a mouth tube;

s5, sealing the mouth tube by using the cover body.

As a further improvement of the above technical scheme: the sealing element is an easy-to-tear film.

As a further improvement of the above technical scheme: the specific process of step S1 is as follows: the easy-to-tear film is welded with the mouth tube, and then the mouth tube is welded with the large transfusion soft bag film to manufacture the soft bag.

As a further improvement of the above technical scheme: the sealing piece is a frangible part or a cutting part.

As a further improvement of the above technical scheme: steps S1 to S2 and steps S2 to S4 each convey the flexible bag by clamping the mouth tube of the flexible bag.

Compared with the prior art, the invention has the advantages that: the invention discloses a non-terminally sterilized large transfusion soft bag production process, which comprises the steps of firstly arranging a removable sealing piece on a mouth tube to temporarily seal the mouth tube, then sterilizing, removing the sealing piece after sterilization is finished, and filling the mouth tube in an open state, so that the mouth tube can be filled, and sealing the mouth tube by a cover body after filling is finished to prepare a non-terminally sterilized large transfusion soft bag product; the bag body is not required to be cut into an opening and filled from the opening, the problem that the bag opening success rate is low or an expensive powder-liquid multi-chamber bag infusion film is adopted for making bags is avoided, the deformation of the bag body in the sterilization process does not influence the subsequent filling through the mouth tube, so that the empty bag can be normally loaded during sterilization, the empty bag is not required to be completely positioned, the process feasibility is good, the qualification rate and the productivity are improved, the use cost of the packaging material is reduced, and the large-batch continuous stable production is easier to realize.

Drawings

FIG. 1 is a schematic flow chart of a first embodiment of a process for producing a non-terminally sterilized large soft infusion bag according to the invention.

FIG. 2 is a schematic illustration of the welding process of the spout and seal of the present invention.

Fig. 3 is a schematic flow chart of a second embodiment of the present invention.

Fig. 4 is a schematic flow chart of a third embodiment of the present invention.

Fig. 5 is a schematic flow chart of a fourth embodiment of the present invention.

Fig. 6 is a schematic flow chart of a fifth embodiment of the present invention.

The reference numerals in the drawings denote: 1. a soft bag; 11. a bag body; 12. a mouth tube; 13. a seal; 131. the plane is easy to uncover the film; 132. bending the easy-to-uncover film; 14. a large transfusion soft bag film; 2. a cover body; 3. a sterilization device; 4. the medicine liquid.

Detailed Description

As used in this section and in the claims, the terms "a," "an," "the," and/or "the" are not specific to a singular, but may include a plurality, unless the context clearly dictates otherwise. The use of the terms "first," "second," and the like in this section does not denote any order, quantity, or importance, but rather are used to distinguish one element from another. Likewise, the word "comprising" or "comprises", and the like, means that elements or items preceding the word are included in the element or item listed after the word and equivalents thereof, but does not exclude other elements or items. The terms "connected" or "connected," and the like, are not limited to physical or mechanical connections, but may include electrical connections, whether direct or indirect.

The invention is described in further detail below with reference to the drawings and specific examples of the specification.

Example 1

Fig. 1 to 2 show an embodiment of the non-terminally sterilized large soft infusion bag production process of the present invention, which comprises the steps of:

s1, preparing a sealed soft bag 1, wherein the soft bag 1 comprises a bag body 11 and a mouth tube 12 connected with the bag body 11 (in the embodiment, a single mouth tube 12 is arranged on the soft bag 1), and a sealing element 13 for sealing is arranged on the mouth tube 12;

s2, sterilizing the soft bag 1 in a water bath or steam high-temperature sterilization mode which is commonly adopted;

s3, removing the sealing piece 13 on the mouth tube 12;

s4, filling through the mouth tube 12;

s5, sealing the mouth tube 12 by using the cover body 2.

In the non-terminally sterilized large soft infusion bag production process of the embodiment, a removable sealing piece 13 is arranged on a mouth tube 12 to temporarily seal the mouth tube 12, then sterilization is carried out, the sealing piece 13 is removed after sterilization is finished, and the mouth tube 12 is in an open state at the moment, so that the mouth tube 12 can be filled later, and the mouth tube 12 is sealed by a cover body 2 after the filling is finished, so that a non-terminally sterilized large soft infusion bag product is manufactured; the problem that the bag opening success rate is low or the bag is made by adopting an expensive powder-liquid multi-chamber bag infusion film is avoided because an opening is not required to be cut on the bag body 11 (usually, the end, far away from the mouth tube 12, of the bag body 11 is also called as a tail opening and a tail filling), the problem that the bag opening success rate is low or the bag is made by adopting an expensive powder-liquid multi-chamber bag infusion film is avoided, the deformation of the bag body 11 in the sterilization process also does not influence the subsequent filling through the mouth tube 12, so that the empty bag can be normally loaded during sterilization, the empty bag is not required to be completely positioned, the filling is carried out through the mouth tube 12, the liquid medicine on the inner wall of the mouth tube 12 also does not influence the connection and sealing of the subsequent cover body 2 and the mouth tube 12, the process feasibility is good, the qualification rate and the productivity are improved, the use cost of the packaging material is reduced, and the mass continuous stable production is easier to realize.

As a preferred embodiment, the sealing member 13 is a peel-off film (or peel-off film), which can be cut from a film material, is easy to manufacture and low in cost, and can effectively seal the mouth tube 12 and is easy to remove after sterilization. Of course, in other embodiments, the opening tube 12 may be provided with a frangible portion or a breakable portion for temporary sealing, and the opening tube 12 may be opened by breaking the frangible portion or cutting the breakable portion after sterilization, which is disadvantageous in that the structure of the opening tube 12 becomes complicated, the cost is correspondingly increased, and the difficulty of removing the frangible portion or the breakable portion is greater than the difficulty of tearing off the frangible film. Referring specifically to fig. 2, the easy-to-peel film may be a planar easy-to-peel film 131 or a folded easy-to-peel film 132.

Further, in this embodiment, the specific process of step S1 is as follows: the easy-to-tear film is welded with the mouth tube 12, and then the mouth tube 12 is welded with the large transfusion soft bag film 14 to manufacture the soft bag 1. The working procedures of film feeding, printing and the like of the large transfusion soft bag film 14 can be synchronously carried out with the working procedures of cutting, welding and the like of the easy-to-tear film, which is beneficial to further improving the efficiency of preparing the soft bag 1. Of course, in other embodiments, after the mouth tube 12 is welded to the large infusion soft bag film 14 and the soft bag 1 is manufactured, the easy-to-tear film is welded to the mouth tube 12, which has the disadvantage that the efficiency is reduced compared with the present embodiment.

Further, in the present embodiment, steps S1 to S2 and steps S2 to S4 each convey the flexible bag 1 by sandwiching the mouth tube 12 of the flexible bag 1. The sterilization and filling process utilizes the mouth tube 12 for conveying and positioning, is simple and efficient, and avoids the existing complicated positioning and conveying mechanism which is complicated in process and is filled and sealed through the tail part.

Example two

Fig. 3 shows another embodiment of the non-terminally sterilized large infusion soft bag production process of the present invention, which is substantially the same as the first embodiment except that:

in this embodiment, when the soft bag 1 is manufactured, two independent mouth pipes 12 are provided on the soft bag 1, wherein a film easy to be torn off is welded on one mouth pipe 12 to realize temporary sealing, and then the soft bag can be used for filling, and a cover body 2 is provided on the other mouth pipe 12 to always maintain a sealing state.

Example III

Fig. 4 shows another embodiment of the non-terminally sterilized large infusion soft bag production process of the present invention, which is substantially the same as the second embodiment except that:

in this embodiment, when preparing the soft bag 1, two independent mouth pipes 12 are provided on the soft bag 1, the films easy to be torn are welded on the two mouth pipes 12 to realize temporary sealing, the films easy to be torn on the two mouth pipes 12 are removed before filling, and filling is performed through the two mouth pipes 12 during filling, so that the time for filling is shortened, and the filling efficiency is further improved.

Example IV

Fig. 5 shows another embodiment of the non-terminally sterilized large infusion soft bag production process of the present invention, which is substantially the same as the third embodiment except that:

in this embodiment, the mouth tube 12 is a single-seat double-mouth tube (i.e. two mouth tubes 12 share a seat), the two mouth tubes 12 are welded with easy-to-tear films to realize temporary sealing, and the easy-to-tear films on the two mouth tubes 12 are removed before filling, so that the two mouth tubes 12 are filled during filling, which is beneficial to shortening the filling time and further improving the filling efficiency.

Example five

Fig. 6 shows another embodiment of the non-terminally sterilized large infusion soft bag manufacturing process of the present invention, which is substantially the same as the fourth embodiment (the port tube 12 is also a single-seat double-port tube), except that:

in this embodiment, the easy-to-tear film is welded on one of the mouth pipes 12 to realize temporary sealing, and the other mouth pipe 12 is provided with the cover body 2 for filling later, so that the sealing state is always maintained.

While the invention has been described with reference to preferred embodiments, it is not intended to be limiting. Many possible variations and modifications of the disclosed technology can be made by anyone skilled in the art, or equivalent embodiments with equivalent variations can be made, without departing from the scope of the invention. Therefore, any simple modification, equivalent variation and modification of the above embodiments according to the technical substance of the present invention shall fall within the scope of the technical solution of the present invention.

Claims

1. A non-terminal sterilized large transfusion soft bag production process is characterized in that: the method comprises the following steps:

s1, preparing a sealed soft bag (1), wherein the soft bag (1) comprises a bag body (11) and a mouth tube (12) connected with the bag body (11), and a sealing element (13) for sealing is arranged on at least one mouth tube (12);

s2, sterilizing the soft bag (1);

s3, removing a sealing piece (13) on the mouth tube (12);

s4, filling through a mouth tube (12);

s5, sealing the mouth tube (12) by using the cover body (2).

2. The non-terminally sterilized large infusion soft bag production process according to claim 1, wherein: the sealing element (13) is an easy-to-tear film.

3. The non-terminally sterilized large infusion soft bag production process according to claim 2, wherein: the specific process of step S1 is as follows: the easy-to-tear film is welded with the mouth tube (12), and then the mouth tube (12) is welded with the large transfusion soft bag film (14) to manufacture the soft bag (1).

4. The non-terminally sterilized large infusion soft bag production process according to claim 1, wherein: the sealing element (13) is a frangible portion or a cut-away portion.

5. The non-terminally sterilized large infusion soft bag production process according to any one of claims 1 to 4, wherein: steps S1 to S2 and steps S2 to S4 each convey the flexible bag (1) by clamping the mouth tube (12) of the flexible bag (1).