CN102488617A - Sodium bicarbonate injection plastic soft bag package and preparation method thereof - Google Patents
Sodium bicarbonate injection plastic soft bag package and preparation method thereof Download PDFInfo
- Publication number
- CN102488617A CN102488617A CN2011103730290A CN201110373029A CN102488617A CN 102488617 A CN102488617 A CN 102488617A CN 2011103730290 A CN2011103730290 A CN 2011103730290A CN 201110373029 A CN201110373029 A CN 201110373029A CN 102488617 A CN102488617 A CN 102488617A
- Authority
- CN
- China
- Prior art keywords
- sodium bicarbonate
- bag
- inner bag
- bicarbonate injection
- filled
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Images
Landscapes
- Medical Preparation Storing Or Oral Administration Devices (AREA)
Abstract
The invention discloses a sodium bicarbonate injection plastic soft bag package and a preparation method thereof. The package comprises an outer bag and a medical soft plastic inner bag, the outer bag is made of gas-barrier materials, the medical soft plastic inner bag is arranged in the outer bag, the inner bag is filled with sodium bicarbonate injection after being vacuumized or is vacuumized after being filled with the sodium bicarbonate injection or is filled up with the sodium bicarbonate injection, carbon dioxide gas is filled in a cavity between the inner bag and the outer bag, and the inner bag filled with the sodium bicarbonate injection is placed in the outer bag after being in high-temperature sterilization treatment. The preparation method is simple and convenient, production, processing and storage are convenient, decomposition of the sodium bicarbonate injection can be prevented effectively, liquid medicine can be in a relatively balance state, stability of the liquid medicine is guaranteed, the quality of transfusion liquid is guaranteed, and simultaneously, operation during transfusion is also convenient.
Description
Technical field
The present invention relates to the medical packaging field, especially a kind of sodium bicarbonate injection plastics packed in flexible pouchy and preparation method thereof.
Background technology
In the medical packaging field, has good stability, with low cost, the medical plastic that is difficult for advantages such as fragmentation packing replaces glass bottle packaging gradually, becomes the main flow of medical packaging.
For sodium bicarbonate injection; Because the unstable chemcial property of sodium bicarbonate; Therefore sodium bicarbonate injection resolves into sodium carbonate, carbon dioxide and water easily in storage, use; Thereby pH value changes, and possibly cause importing producing untoward reaction in the human body, so the bad plastics package of choke effect possibly produce potential risks.Given this; The patent No. is 200720177747.X; The Chinese patent that name is called " sodium bicarbonate injection plastic bag packaging " provides a kind of plastic packaging bag of sodium bicarbonate injection, employing be that the plastics inner bag that holds sodium bicarbonate injection is set in the outer packaging bag of gas-barrier material, wherein; All be filled with carbon dioxide in the cavity of inner bag and outer packaging bag, thereby realize the poised state of sodium bicarbonate injection.But there is open defect in this packing, because inner bag fills carbon dioxide, bag gross distortion even disruptive situation can take place when high temperature sterilize, has a strong impact on the quality of sodium bicarbonate injection packing and the use of injection.In order to overcome these defectives; Application number is 201020586323.0; The day for announcing is on June 29th, 2011; The Chinese patent that name is called " sodium bicarbonate injection soft packaging bag " provides a kind of inner bag to fill with sodium bicarbonate injection, and outer packaging bag is the plastics package of the sodium bicarbonate injection of vacuum state.But there is defective equally in this packing, though inner bag is filled with sodium bicarbonate injection, still can't prevent the decomposition of sodium bicarbonate injection, and there is variation equally in the pH value of injection, when high temperature sterilize, can expire and dilatancy very much because of interior bag injection equally.
Summary of the invention
Problem to the prior art existence; The object of the present invention is to provide a kind of being convenient to produce; Guarantee the sodium bicarbonate injection plastics packed in flexible pouchy that bag interior injection chemical property is stable simultaneously, another object of the present invention provides a kind of method for preparing of above-mentioned plastics packed in flexible pouchy.
For realizing above-mentioned purpose; A kind of sodium bicarbonate injection plastics of the present invention packed in flexible pouchy; This plastics packed in flexible pouchy comprises the medical flexible plastic inner bag by the gas-barrier material outer bag of processing and the portion that sets within it; Evacuation or fill sodium bicarbonate injection behind fill sodium bicarbonate injection or the fill sodium bicarbonate injection behind the evacuation in the inner bag; Be filled with carbon dioxide in the cavity between inner bag and the outer bag, wherein, the inner bag that is filled with sodium bicarbonate injection reinstalls after high temperature sterilize is handled in outer bag.
Further, said outer bag is a M712 high-barrier outer packaging bag.
Further, said outer bag is provided with the third connecting pipe of in it, inflating.
Further, be provided with a communicating pipe that communicates with its closed cavity on the said inner bag at least.
Further, said inner bag is provided with first communicating pipe and second communicating pipe that communicates with its closed cavity.
Further, said first communicating pipe is an injection derivation/delivery line, and the chemical feed pipe of medicament is added in the adding when said second communicating pipe is vacuum-pumping tube and/or transfusion.
Further, said first communicating pipe and second communicating pipe are arranged side by side the same end at said inner bag, perhaps are separately positioned on the relative two ends of said inner bag.
A kind of method for preparing of above-mentioned sodium bicarbonate injection plastics packed in flexible pouchy is specially:
1) prepares the medical plastic inner bag;
2) earlier the sodium bicarbonate injection that configures is filled in the inner bag again with the residual gas evacuation in the bag, perhaps earlier the inner bag evacuation is filled into the sodium bicarbonate injection that configures again;
3) with the inner bag integral sealing;
4) carry out lamp inspection to internal bag;
5) inner bag after qualified carries out high temperature sterilize and handles with lamp inspection;
6) inner bag is placed outer bag;
7) to inner bag and outside the bag between cavity in charge into carbon dioxide;
8) will outer bag integral sealing.
Method for preparing of the present invention is simple, convenient, is convenient to produce, processes and storage, can effectively prevent the decomposition of sodium bicarbonate injection; Make medicinal liquid can be in the state of a relative equilibrium; Guaranteed the stability of medicinal liquid, guaranteed the quality of transfusion liquid, the operation when also having made things convenient for simultaneously transfusion.
Description of drawings
Fig. 1 is a plastics packed in flexible pouchy structural representation one of the present invention;
Fig. 2 is a plastics packed in flexible pouchy structural representation two of the present invention;
Fig. 3 is a plastics packed in flexible pouchy structural representation three of the present invention.
The specific embodiment
Below, with reference to accompanying drawing, the present invention is more comprehensively explained, exemplary embodiment of the present invention has been shown in the accompanying drawing.Yet the present invention can be presented as multiple multi-form, and should not be construed as the exemplary embodiment that is confined to narrate here.But, these embodiment are provided, thereby make the present invention, and scope of the present invention is fully conveyed to those of ordinary skill in the art comprehensively with complete.
In order to be easy to explanation, here can use such as " on ", D score " left side " space relative terms such as " right sides ", be used for element shown in the key diagram or characteristic relation with respect to another element or characteristic.It should be understood that except the orientation shown in the figure spatial terminology is intended to comprise the different azimuth of device in using or operating.For example, if the device among the figure is squeezed, be stated as the element that is positioned at other elements or characteristic D score will be positioned at other elements or characteristic " on ".Therefore, the exemplary term D score can comprise upper and lower orientation both.Device can otherwise be located (revolve turn 90 degrees or be positioned at other orientation), and the relative explanation in used here space can correspondingly be explained.
The method for preparing of sodium bicarbonate injection plastics packed in flexible pouchy of the present invention is specially:
1) prepares the medical plastic inner bag;
2) earlier the sodium bicarbonate injection that configures is filled in the inner bag again with the residual gas evacuation in the bag, perhaps earlier the inner bag evacuation is filled into the sodium bicarbonate injection that configures again;
3) with the inner bag integral sealing;
4) carry out lamp inspection to internal bag;
5) inner bag after qualified carries out high temperature sterilize and handles with lamp inspection;
6) inner bag is placed outer bag;
7) to inner bag and outside the bag between cavity in charge into carbon dioxide;
8) will outer bag integral sealing.
The sodium bicarbonate injection plastics packed in flexible pouchy that utilizes method for preparing of the present invention to make; Extremely shown in Figure 3 like Fig. 1; This plastics packed in flexible pouchy comprises inner bag 1 and outer bag 2; Inner bag 1 places outer bag 2, is filled with carbon dioxide 22 at interval the cavity between inner bag 1 and the outer bag 2, and the inner bag 1 that is filled with sodium bicarbonate injection reinstalls after high temperature sterilize is handled in outer bag 2.Inner bag 1 is processed by medical flexible plastic, and outer bag 2 is processed by gas-barrier material.In the present embodiment; Outer bag 2 adopts M712 high-barrier outer packaging bag; This M712 barrier bag is that Xi Yueer packing (Shanghai) Co., Ltd. produces; It is that the ideal of the infusion products of oxygen and carbon dioxide sensitivity is selected, and its superelevation barrier property is for guaranteeing that transfusion quality and drug effect play crucial effects.In the practical application, outer bag 2 also can adopt other various gas-barrier materials, as has the composite film material etc. of gas barrier layer.
Adopt behind the evacuation behind fill sodium bicarbonate injection or the fill sodium bicarbonate injection evacuation in the inner bag 1 or fill sodium bicarbonate injection.In the present embodiment, partial volume is filled with sodium bicarbonate injection 11 in the inner bag 1, and the closed cavity of inner bag 1 comprises dress liquid portion and vacuum 12, and the most of volume in the inner bag 1 is used to hold sodium bicarbonate injection 11, and this major part volume forms dress liquid portion; Other fraction volume in the inner bag 1 is evacuated, and this fraction volume forms vacuum 12.
In step 7), weld third connecting pipe 21 on the bag 2 outside earlier, in cavity, charge into carbon dioxide through third connecting pipe 21.Third connecting pipe 21 is convenient to the operation that charges into of carbon dioxide, simultaneously since outside the bag 2 and inner bag 1 between cavity charged into carbon dioxide 22; Form the extraneous gas environment of inner bag 1; Because the decomposition reaction of sodium bicarbonate is reversible reaction, as long as guarantee the extraneous gas environment of inner bag 1 carbon dioxide of capacity is arranged, the sodium bicarbonate injection 11 in the inner bag 1 will keep poised state; Be difficult for decomposing, thereby the chemical property that guarantees sodium bicarbonate injection 11 is stable.
At least be provided with a communicating pipe that communicates with its closed cavity on the inner bag 1; In the present embodiment; In step 1), on said inner bag, be welded with first communicating pipe 13 and second communicating pipe 14 that communicate with its closed cavity, wherein; First communicating pipe 13 was injection derivation/delivery line, and the chemical feed pipe of medicament is added in the adding when second communicating pipe 14 was vacuum-pumping tube and/or transfusion.Through first communicating pipe 13 and second communicating pipe 14 are set, both made things convenient for filling liquid and the process operations of evacuation of inner bag 1 in the preparation process, also made things convenient for the operation of dosing when giving patient infusion.First communicating pipe 13 and second communicating pipe 14 can be arranged side by side the same end at inner bag 1, perhaps are separately positioned on the relative two ends of inner bag 1.
Beneficial effect of the present invention:
1, owing in the inner bag 1 vacuum 12 is set, overcomes the gas expansion when high temperature sterilize, caused the defective of bag distortion or broken bag;
2, the cavity between outer bag 2 and the inner bag 1 has charged into carbon dioxide 22; Gas-barrier material is processed outer bag 2 is enclosed in carbon dioxide in the closed environment; The sodium bicarbonate injection that has guaranteed inner bag 1 is in poised state, has guaranteed the stability of medicinal liquid;
3, the setting of third connecting pipe 21 has then made things convenient for charging into of carbon dioxide on the outer bag 2, and the operation when the doubly-linked siphunculus is set on the inner bag then for bag work and transfusion is provided convenience;
4, adopt the mode of outsourcing protection bag, realized the purpose with the plastic bag packaging sodium bicarbonate injection, be convenient to produce, process and storage, cost is low.
Claims (8)
1. sodium bicarbonate injection plastics packed in flexible pouchy; It is characterized in that; This plastics packed in flexible pouchy comprises the medical flexible plastic inner bag of the outer bag of being processed by gas-barrier material and the portion that sets within it, and evacuation or fill sodium bicarbonate injection behind fill sodium bicarbonate injection or the fill sodium bicarbonate injection behind the evacuation is filled with carbon dioxide in the cavity between inner bag and the outer bag in the inner bag; Wherein, the inner bag that is filled with sodium bicarbonate injection reinstalls after high temperature sterilize is handled in outer bag.
2. sodium bicarbonate injection plastics packed in flexible pouchy as claimed in claim 1 is characterized in that, said outer bag is a M712 high-barrier outer packaging bag.
3. sodium bicarbonate injection plastics packed in flexible pouchy as claimed in claim 2 is characterized in that, said outer bag is provided with the third connecting pipe of in it, inflating.
4. sodium bicarbonate injection plastics packed in flexible pouchy as claimed in claim 1 is characterized in that, is provided with a communicating pipe that communicates with its closed cavity on the said inner bag at least.
5. sodium bicarbonate injection plastics packed in flexible pouchy as claimed in claim 4 is characterized in that, said inner bag is provided with first communicating pipe and second communicating pipe that communicates with its closed cavity.
6. sodium bicarbonate injection plastics packed in flexible pouchy as claimed in claim 5 is characterized in that said first communicating pipe is an injection derivation/delivery line, and the chemical feed pipe of medicament is added in the adding when said second communicating pipe is vacuum-pumping tube and/or transfusion.
7. sodium bicarbonate injection plastics packed in flexible pouchy as claimed in claim 6 is characterized in that said first communicating pipe and second communicating pipe are arranged side by side the same end at said inner bag, perhaps is separately positioned on the relative two ends of said inner bag.
8. the method for preparing of a sodium bicarbonate injection plastics packed in flexible pouchy as claimed in claim 1 is characterized in that, this method for preparing is specially:
1) prepares the medical plastic inner bag;
2) earlier the sodium bicarbonate injection that configures is filled in the inner bag again with the residual gas evacuation in the bag, perhaps earlier the inner bag evacuation is filled into the sodium bicarbonate injection that configures again;
3) with the inner bag integral sealing;
4) carry out lamp inspection to internal bag;
5) inner bag after qualified carries out high temperature sterilize and handles with lamp inspection;
6) inner bag is placed outer bag;
7) to inner bag and outside the bag between cavity in charge into carbon dioxide;
8) will outer bag integral sealing.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2011103730290A CN102488617A (en) | 2011-11-22 | 2011-11-22 | Sodium bicarbonate injection plastic soft bag package and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2011103730290A CN102488617A (en) | 2011-11-22 | 2011-11-22 | Sodium bicarbonate injection plastic soft bag package and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN102488617A true CN102488617A (en) | 2012-06-13 |
Family
ID=46180525
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2011103730290A Pending CN102488617A (en) | 2011-11-22 | 2011-11-22 | Sodium bicarbonate injection plastic soft bag package and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN102488617A (en) |
Cited By (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102730207A (en) * | 2012-07-10 | 2012-10-17 | 山东齐都药业有限公司 | Production process for double-layer sterile flexibly-packaged infusion bag |
| CN102826260A (en) * | 2012-09-26 | 2012-12-19 | 山东齐都药业有限公司 | Production process of dual-layer sterile soft package infusion solution |
| CN103142409A (en) * | 2013-03-29 | 2013-06-12 | 回音必集团(江西)东亚制药有限公司 | Method for guarteeing product quality of injection for plastic bottle or soft bag |
| CN103230338A (en) * | 2013-03-29 | 2013-08-07 | 回音必集团(江西)东亚制药有限公司 | Method for stabilizing product quality of sodium bicarbonate injection |
| CN103431996A (en) * | 2013-08-30 | 2013-12-11 | 山东华鲁制药有限公司 | Transfusion plastic container for containing medicine liquid |
| CN103754403A (en) * | 2014-01-08 | 2014-04-30 | 中国大冢制药有限公司 | Method for packaging sodium bicarbonate injection |
| CN104107140A (en) * | 2014-06-23 | 2014-10-22 | 武汉药谷生物工程有限公司 | Flexible package for injections including sodium bicarbonate |
| CN105151566A (en) * | 2015-07-29 | 2015-12-16 | 重庆市南川区庆岩福利碱厂 | Packaging bag of sodium sulfide and using method thereof |
| CN113577018A (en) * | 2021-07-26 | 2021-11-02 | 四川太平洋药业有限责任公司 | Preparation process of sodium bicarbonate injection |
| US11925703B1 (en) | 2022-07-29 | 2024-03-12 | Xellia Pharmaceuticals Aps | Liquid composition comprising glucose |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN201082253Y (en) * | 2007-09-10 | 2008-07-09 | 湖南千山制药机械股份有限公司 | Sodium bicarbonate injection plastic bag packaging |
| CN101461756A (en) * | 2007-12-17 | 2009-06-24 | 丽珠集团利民制药厂 | Medicine liquid flexible package and method for packing the same |
| CN201880025U (en) * | 2010-11-01 | 2011-06-29 | 成都青山利康药业有限公司 | Soft packing bag of sodium bicarbonate injection |
| CN202366162U (en) * | 2011-11-22 | 2012-08-08 | 四川科伦药物研究有限公司 | Plastic soft packaging bag for sodium bicarbonate injection |
-
2011
- 2011-11-22 CN CN2011103730290A patent/CN102488617A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN201082253Y (en) * | 2007-09-10 | 2008-07-09 | 湖南千山制药机械股份有限公司 | Sodium bicarbonate injection plastic bag packaging |
| CN101461756A (en) * | 2007-12-17 | 2009-06-24 | 丽珠集团利民制药厂 | Medicine liquid flexible package and method for packing the same |
| CN201880025U (en) * | 2010-11-01 | 2011-06-29 | 成都青山利康药业有限公司 | Soft packing bag of sodium bicarbonate injection |
| CN202366162U (en) * | 2011-11-22 | 2012-08-08 | 四川科伦药物研究有限公司 | Plastic soft packaging bag for sodium bicarbonate injection |
Cited By (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102730207A (en) * | 2012-07-10 | 2012-10-17 | 山东齐都药业有限公司 | Production process for double-layer sterile flexibly-packaged infusion bag |
| CN102826260A (en) * | 2012-09-26 | 2012-12-19 | 山东齐都药业有限公司 | Production process of dual-layer sterile soft package infusion solution |
| CN102826260B (en) * | 2012-09-26 | 2014-06-25 | 山东齐都药业有限公司 | Production process of dual-layer sterile soft package infusion solution |
| CN103230338B (en) * | 2013-03-29 | 2014-01-08 | 回音必集团(江西)东亚制药有限公司 | Method for stabilizing product quality of sodium bicarbonate injection |
| CN103142409B (en) * | 2013-03-29 | 2014-01-08 | 回音必集团(江西)东亚制药有限公司 | Method for guarteeing product quality of injection for plastic bottle or soft bag |
| CN103230338A (en) * | 2013-03-29 | 2013-08-07 | 回音必集团(江西)东亚制药有限公司 | Method for stabilizing product quality of sodium bicarbonate injection |
| CN103142409A (en) * | 2013-03-29 | 2013-06-12 | 回音必集团(江西)东亚制药有限公司 | Method for guarteeing product quality of injection for plastic bottle or soft bag |
| CN103431996A (en) * | 2013-08-30 | 2013-12-11 | 山东华鲁制药有限公司 | Transfusion plastic container for containing medicine liquid |
| CN103754403A (en) * | 2014-01-08 | 2014-04-30 | 中国大冢制药有限公司 | Method for packaging sodium bicarbonate injection |
| CN103754403B (en) * | 2014-01-08 | 2016-06-01 | 中国大冢制药有限公司 | The Packaging Method of sodium bicarbonate injection |
| CN104107140A (en) * | 2014-06-23 | 2014-10-22 | 武汉药谷生物工程有限公司 | Flexible package for injections including sodium bicarbonate |
| CN105151566A (en) * | 2015-07-29 | 2015-12-16 | 重庆市南川区庆岩福利碱厂 | Packaging bag of sodium sulfide and using method thereof |
| CN105151566B (en) * | 2015-07-29 | 2018-06-22 | 重庆市南川区庆岩福利碱厂 | The packaging bag application method of vulcanized sodium |
| CN113577018A (en) * | 2021-07-26 | 2021-11-02 | 四川太平洋药业有限责任公司 | Preparation process of sodium bicarbonate injection |
| US11925703B1 (en) | 2022-07-29 | 2024-03-12 | Xellia Pharmaceuticals Aps | Liquid composition comprising glucose |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN102488617A (en) | Sodium bicarbonate injection plastic soft bag package and preparation method thereof | |
| CN102068379B (en) | Dual-cavity aseptic bag and manufacturing method thereof | |
| CN102090976A (en) | Three-cavity sterile bag and preparation method thereof | |
| CN101401769A (en) | Package container for sodium bicarbonate injection and method of preparing the same | |
| CN202366163U (en) | Plastic bottle package for sodium bicarbonate injection | |
| CN105030534B (en) | A kind of sodium bicarbonate injection double-layer sterile packed in flexible pouchy system and preparation method thereof | |
| CN201082253Y (en) | Sodium bicarbonate injection plastic bag packaging | |
| CN202366162U (en) | Plastic soft packaging bag for sodium bicarbonate injection | |
| CN201094733Y (en) | Parallel three-chamber large infusion package bag with hard interface | |
| CN101117168A (en) | Sodium hydrogen carbonate injection plastic package and production method thereof | |
| CN105540009A (en) | Soft plastic bag package for sodium bicarbonate injection | |
| CN103156770A (en) | Production method of high-capacity liquid powder bag container | |
| JP2006206140A (en) | Sterilization packing method of two-closure-having pouch | |
| JP4503953B2 (en) | Manufacturing method of prefilled syringe | |
| CN201880025U (en) | Soft packing bag of sodium bicarbonate injection | |
| CN203107695U (en) | Sodium bicarbonate injection flexible package | |
| CN201085784Y (en) | Single-group oral siphon liquid double-cavity transfusion soft bag | |
| CN201116193Y (en) | Sodium bicarbonate injection plastic bottle packaging | |
| CN101317808B (en) | Packaging for sodium bicarbonate injection and preparation thereof | |
| CN201213906Y (en) | Multi-chamber type infusion bag | |
| CN104162372A (en) | Gas quantitative blending and speed-controlled transmission method and device based on water-gas exchange technology | |
| CN104548153A (en) | Encapsulation and sterilization method of softly-bagged compound amino acid injection | |
| CN102614081A (en) | Transfusion bag for accommodating sodium bicarbonate injection, and production method for transfusion bag | |
| CN206391202U (en) | A kind of medicinal glass bottle | |
| CN205019418U (en) | Infusion bottle |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C12 | Rejection of a patent application after its publication | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20120613 |