CN115989235A - 使用氨基酸化合物治疗呼吸系统疾病的方法 - Google Patents
使用氨基酸化合物治疗呼吸系统疾病的方法 Download PDFInfo
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- CN115989235A CN115989235A CN202180048580.XA CN202180048580A CN115989235A CN 115989235 A CN115989235 A CN 115989235A CN 202180048580 A CN202180048580 A CN 202180048580A CN 115989235 A CN115989235 A CN 115989235A
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- ZMPQYYQUMXERAI-UHFFFAOYSA-N 2-[(5-cyanopyrimidin-2-yl)amino]-4-[2,2-difluoroethyl-[4-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)butyl]amino]butanoic acid Chemical compound C(#N)C=1C=NC(=NC=1)NC(C(=O)O)CCN(CCCCC1=NC=2NCCCC=2C=C1)CC(F)F ZMPQYYQUMXERAI-UHFFFAOYSA-N 0.000 description 1
- OZSSSUOOQQMKPH-UHFFFAOYSA-N 2-[(5-cyanopyrimidin-2-yl)amino]-4-[2-(4-fluorophenoxy)ethyl-[4-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)butyl]amino]butanoic acid Chemical compound C(#N)C=1C=NC(=NC=1)NC(C(=O)O)CCN(CCCCC1=NC=2NCCCC=2C=C1)CCOC1=CC=C(C=C1)F OZSSSUOOQQMKPH-UHFFFAOYSA-N 0.000 description 1
- OMYWJDHKUOTHKT-UHFFFAOYSA-N 2-[(5-cyanopyrimidin-2-yl)amino]-4-[2-methoxypropyl-[4-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)butyl]amino]butanoic acid Chemical compound C(#N)C=1C=NC(=NC=1)NC(C(=O)O)CCN(CCCCC1=NC=2NCCCC=2C=C1)CC(C)OC OMYWJDHKUOTHKT-UHFFFAOYSA-N 0.000 description 1
- KGLKXFBEHNTXQA-UHFFFAOYSA-N 2-[(5-cyanopyrimidin-2-yl)amino]-4-[2-phenoxyethyl-[4-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)butyl]amino]butanoic acid Chemical compound C(#N)C=1C=NC(=NC=1)NC(C(=O)O)CCN(CCCCC1=NC=2NCCCC=2C=C1)CCOC1=CC=CC=C1 KGLKXFBEHNTXQA-UHFFFAOYSA-N 0.000 description 1
- HRDIRQDRRJCNJC-UHFFFAOYSA-N 2-[(5-cyclopropylpyrimidin-2-yl)amino]-4-[2,2-difluoroethyl-[4-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)butyl]amino]butanoic acid Chemical compound C1(CC1)C=1C=NC(=NC=1)NC(C(=O)O)CCN(CCCCC1=NC=2NCCCC=2C=C1)CC(F)F HRDIRQDRRJCNJC-UHFFFAOYSA-N 0.000 description 1
- VGDLBRUTGYZVLA-UHFFFAOYSA-N 2-[(5-cyclopropylpyrimidin-2-yl)amino]-4-[2-methoxypropyl-[4-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)butyl]amino]butanoic acid Chemical compound C1(CC1)C=1C=NC(=NC=1)NC(C(=O)O)CCN(CCCCC1=NC=2NCCCC=2C=C1)CC(C)OC VGDLBRUTGYZVLA-UHFFFAOYSA-N 0.000 description 1
- MSOZXWRLSFBGRJ-UHFFFAOYSA-N 2-[(5-cyclopropylpyrimidin-2-yl)amino]-4-[2-phenoxyethyl-[4-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)butyl]amino]butanoic acid Chemical compound C1(CC1)C=1C=NC(=NC=1)NC(C(=O)O)CCN(CCCCC1=NC=2NCCCC=2C=C1)CCOC1=CC=CC=C1 MSOZXWRLSFBGRJ-UHFFFAOYSA-N 0.000 description 1
- WRAPGMNNYFJAFF-UHFFFAOYSA-N 2-[(5-cyclopropylpyrimidin-2-yl)amino]-4-[3,3-difluoropropyl-[4-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)butyl]amino]butanoic acid Chemical compound C1(CC1)C=1C=NC(=NC=1)NC(C(=O)O)CCN(CCCCC1=NC=2NCCCC=2C=C1)CCC(F)F WRAPGMNNYFJAFF-UHFFFAOYSA-N 0.000 description 1
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- VSRHLQBJZGNGLG-UHFFFAOYSA-N 2-[(6,7-difluoroquinazolin-4-yl)amino]-4-[2-methoxyethyl-[4-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)butyl]amino]butanoic acid Chemical compound FC=1C=C2C(=NC=NC2=CC=1F)NC(C(=O)O)CCN(CCCCC1=NC=2NCCCC=2C=C1)CCOC VSRHLQBJZGNGLG-UHFFFAOYSA-N 0.000 description 1
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- JIRFVZBHOYIAGH-UHFFFAOYSA-N 2-[(7-fluoro-2-methylquinazolin-4-yl)amino]-4-[2-methoxyethyl-[4-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)butyl]amino]butanoic acid Chemical compound FC1=CC=C2C(=NC(=NC2=C1)C)NC(C(=O)O)CCN(CCCCC1=NC=2NCCCC=2C=C1)CCOC JIRFVZBHOYIAGH-UHFFFAOYSA-N 0.000 description 1
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- SQXIAJNIFTZJMD-UHFFFAOYSA-N 2-[(7-fluoroquinazolin-4-yl)amino]-4-[2-methoxyethyl-[4-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)butyl]amino]butanoic acid Chemical compound FC1=CC=C2C(=NC=NC2=C1)NC(C(=O)O)CCN(CCCCC1=NC=2NCCCC=2C=C1)CCOC SQXIAJNIFTZJMD-UHFFFAOYSA-N 0.000 description 1
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- 125000004974 2-butenyl group Chemical group C(C=CC)* 0.000 description 1
- 125000000069 2-butynyl group Chemical group [H]C([H])([H])C#CC([H])([H])* 0.000 description 1
- APRMCBSTMFKLEI-UHFFFAOYSA-N 2-chloro-5-methylpyrimidine Chemical compound CC1=CN=C(Cl)N=C1 APRMCBSTMFKLEI-UHFFFAOYSA-N 0.000 description 1
- ASUDFOJKTJLAIK-UHFFFAOYSA-N 2-methoxyethanamine Chemical compound COCCN ASUDFOJKTJLAIK-UHFFFAOYSA-N 0.000 description 1
- 125000003903 2-propenyl group Chemical group [H]C([*])([H])C([H])=C([H])[H] 0.000 description 1
- 125000001494 2-propynyl group Chemical group [H]C#CC([H])([H])* 0.000 description 1
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- 125000004975 3-butenyl group Chemical group C(CC=C)* 0.000 description 1
- 125000000474 3-butynyl group Chemical group [H]C#CC([H])([H])C([H])([H])* 0.000 description 1
- SDLFAEGTVBPHBK-UHFFFAOYSA-N 3-chloropyrazine-2-carbonitrile Chemical compound ClC1=NC=CN=C1C#N SDLFAEGTVBPHBK-UHFFFAOYSA-N 0.000 description 1
- ASNHGEVAWNWCRQ-UHFFFAOYSA-N 4-(hydroxymethyl)oxolane-2,3,4-triol Chemical compound OCC1(O)COC(O)C1O ASNHGEVAWNWCRQ-UHFFFAOYSA-N 0.000 description 1
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| US63/021,674 | 2020-05-07 | ||
| PCT/US2021/030363 WO2021225912A1 (en) | 2020-05-07 | 2021-04-30 | Treatment of respiratory diseases with amino acid compounds |
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| CN115989235A true CN115989235A (zh) | 2023-04-18 |
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| JP (1) | JP2023524970A (https=) |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2024235299A1 (zh) * | 2023-05-17 | 2024-11-21 | 西藏海思科制药有限公司 | 一种羧基衍生物及其在医药上的应用 |
| WO2025067384A1 (zh) * | 2023-09-28 | 2025-04-03 | 成都微芯药业有限公司 | 一类氨基酸整联蛋白抑制剂、其制备方法及其应用 |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3509590A4 (en) | 2016-09-07 | 2020-12-02 | Pliant Therapeutics, Inc. | N-ACYL AMINO ACID COMPOUNDS AND METHODS OF USE |
| US10696672B2 (en) | 2016-12-23 | 2020-06-30 | Pliant Therapeutics, Inc. | Amino acid compounds and methods of use |
| FI3761980T3 (fi) | 2018-03-07 | 2024-02-21 | Pliant Therapeutics Inc | Aminohappoyhdisteitä ja käyttömenetelmiä |
| TWI841573B (zh) | 2018-06-27 | 2024-05-11 | 美商普萊恩醫療公司 | 具有未分支連接子之胺基酸化合物及使用方法 |
| TW202028179A (zh) | 2018-10-08 | 2020-08-01 | 美商普萊恩醫療公司 | 胺基酸化合物及使用方法 |
| CN114173803A (zh) | 2019-04-08 | 2022-03-11 | 普利安特治疗公司 | 氨基酸化合物的剂型和方案 |
| EP4247472A4 (en) * | 2020-11-19 | 2024-10-09 | Pliant Therapeutics, Inc. | INTEGRIN INHIBITORS AND USES THEREOF |
| MX2023012794A (es) * | 2021-04-30 | 2023-12-15 | Pliant Therapeutics Inc | Regímenes de dosificación expandidos para inhibidores de integrina. |
| CN120091811A (zh) * | 2022-07-09 | 2025-06-03 | 普利安特治疗公司 | 整合素抑制剂及其与其它药剂组合的用途 |
| EP4626878A1 (en) | 2022-12-02 | 2025-10-08 | Neumora Therapeutics, Inc. | Methods of treating neurological disorders |
| WO2024125634A1 (zh) * | 2022-12-16 | 2024-06-20 | 西藏海思科制药有限公司 | 一种四氢萘啶类化合物及其在医药上的应用 |
Family Cites Families (8)
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| ATE511850T1 (de) * | 1997-08-08 | 2011-06-15 | Univ California | Behandlung von blasenfibrose mit antikörpern gegen alpha-v-beta-6-integrin |
| DE10204789A1 (de) * | 2002-02-06 | 2003-08-14 | Merck Patent Gmbh | Inhibitoren des Integrins alpha¶v¶beta6 |
| US9790222B2 (en) * | 2015-02-19 | 2017-10-17 | Scifluor Life Sciences, Inc. | Fluorinated tetrahydronaphthyridinyl nonanoic acid derivatives and uses thereof |
| BR112017023432A2 (pt) * | 2015-04-30 | 2018-07-24 | Scifluor Life Sciences Inc | Derivados de ácido propiônico tetra- hidronaftiridinila e usos do mesmo |
| US10118929B2 (en) * | 2016-04-27 | 2018-11-06 | Scifluor Life Sciences, Inc. | Nonanoic and decanoic acid derivatives and uses thereof |
| WO2018183795A1 (en) * | 2017-03-30 | 2018-10-04 | Scifluor Life Sciences, Inc. | Method of making tetrahydronaphthyridinyl nonanoic acid compounds |
| FI3761980T3 (fi) * | 2018-03-07 | 2024-02-21 | Pliant Therapeutics Inc | Aminohappoyhdisteitä ja käyttömenetelmiä |
| BR112021006622A2 (pt) * | 2018-10-09 | 2021-07-20 | Medimmune, Llc | combinações de anticorpos anti-staphylococcus aureus |
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2021
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- 2021-04-30 EP EP25152378.3A patent/EP4520329A3/en not_active Ceased
- 2021-04-30 KR KR1020227042773A patent/KR20230049584A/ko active Pending
- 2021-04-30 MX MX2022013753A patent/MX2022013753A/es unknown
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- 2021-04-30 AU AU2021268889A patent/AU2021268889A1/en not_active Abandoned
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- 2021-04-30 EP EP21799675.0A patent/EP4146264A4/en not_active Withdrawn
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2024235299A1 (zh) * | 2023-05-17 | 2024-11-21 | 西藏海思科制药有限公司 | 一种羧基衍生物及其在医药上的应用 |
| WO2025067384A1 (zh) * | 2023-09-28 | 2025-04-03 | 成都微芯药业有限公司 | 一类氨基酸整联蛋白抑制剂、其制备方法及其应用 |
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| EP4520329A2 (en) | 2025-03-12 |
| KR20230049584A (ko) | 2023-04-13 |
| AU2021268889A1 (en) | 2022-12-15 |
| EP4146264A1 (en) | 2023-03-15 |
| CA3173761A1 (en) | 2021-11-11 |
| US20230181546A1 (en) | 2023-06-15 |
| EP4146264A4 (en) | 2024-07-24 |
| EP4520329A3 (en) | 2025-05-14 |
| WO2021225912A1 (en) | 2021-11-11 |
| JP2023524970A (ja) | 2023-06-14 |
| IL297969A (en) | 2023-01-01 |
| MX2022013753A (es) | 2023-01-30 |
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