CN115989230A - 吡唑[1,5-a]吡啶类化合物及其制备方法与应用 - Google Patents
吡唑[1,5-a]吡啶类化合物及其制备方法与应用 Download PDFInfo
- Publication number
- CN115989230A CN115989230A CN202180047203.4A CN202180047203A CN115989230A CN 115989230 A CN115989230 A CN 115989230A CN 202180047203 A CN202180047203 A CN 202180047203A CN 115989230 A CN115989230 A CN 115989230A
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- China
- Prior art keywords
- compound
- alkyl
- ret
- pharmaceutically acceptable
- halo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4995—Pyrazines or piperazines forming part of bridged ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
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- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Description
PCT国内申请,说明书已公开。
Claims (23)
- PCT国内申请,权利要求书已公开。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN2020106251193 | 2020-07-01 | ||
CN202010625119.3A CN113880865A (zh) | 2020-07-01 | 2020-07-01 | 吡唑[1,5-a]吡啶类化合物及其制备方法与应用 |
PCT/CN2021/103358 WO2022002097A1 (zh) | 2020-07-01 | 2021-06-30 | 吡唑[1,5-a]吡啶类化合物及其制备方法与应用 |
Publications (1)
Publication Number | Publication Date |
---|---|
CN115989230A true CN115989230A (zh) | 2023-04-18 |
Family
ID=79012173
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN202010625119.3A Pending CN113880865A (zh) | 2020-07-01 | 2020-07-01 | 吡唑[1,5-a]吡啶类化合物及其制备方法与应用 |
CN202180047203.4A Pending CN115989230A (zh) | 2020-07-01 | 2021-06-30 | 吡唑[1,5-a]吡啶类化合物及其制备方法与应用 |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN202010625119.3A Pending CN113880865A (zh) | 2020-07-01 | 2020-07-01 | 吡唑[1,5-a]吡啶类化合物及其制备方法与应用 |
Country Status (2)
Country | Link |
---|---|
CN (2) | CN113880865A (zh) |
WO (1) | WO2022002097A1 (zh) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2021088911A1 (zh) * | 2019-11-08 | 2021-05-14 | 杭州邦顺制药有限公司 | 作为ret激酶抑制剂的3、6二氮杂双环[3.1.1]庚烷衍生物 |
WO2023143486A1 (zh) * | 2022-01-29 | 2023-08-03 | 深圳众格生物科技有限公司 | 化合物的盐、晶型、溶剂合物及水合物 |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
TWI704148B (zh) * | 2016-10-10 | 2020-09-11 | 美商亞雷生物製藥股份有限公司 | 作為ret激酶抑制劑之經取代吡唑并[1,5-a]吡啶化合物 |
TWI783057B (zh) * | 2017-10-10 | 2022-11-11 | 美商絡速藥業公司 | 製備6-(2-羥基-2-甲基丙氧基)-4-(6-(6-((6-甲氧基吡啶-3-基)甲基)-3,6-二氮雜雙環[3.1.1]庚-3-基)吡啶-3-基)吡唑并[1,5-a]吡啶-3-甲腈的方法 |
EP3891148A4 (en) * | 2018-12-07 | 2022-09-07 | Sunshine Lake Pharma Co., Ltd. | RET INHIBITOR, PHARMACEUTICAL COMPOSITIONS AND USES THEREOF |
WO2020114487A1 (en) * | 2018-12-07 | 2020-06-11 | Sunshine Lake Pharma Co., Ltd. | Ret inhibitors, pharmaceutical compositions and uses thereof |
US20220259201A1 (en) * | 2019-05-14 | 2022-08-18 | Shanghai Hansoh Biomedical Co., Ltd. | Inhibitor containing bicyclic derivative, preparation method therefor and use thereof |
WO2021088911A1 (zh) * | 2019-11-08 | 2021-05-14 | 杭州邦顺制药有限公司 | 作为ret激酶抑制剂的3、6二氮杂双环[3.1.1]庚烷衍生物 |
CN112939967A (zh) * | 2019-12-11 | 2021-06-11 | 深圳晶泰科技有限公司 | 吡唑并[1,5-a]吡啶类化合物及其制备方法和应用 |
-
2020
- 2020-07-01 CN CN202010625119.3A patent/CN113880865A/zh active Pending
-
2021
- 2021-06-30 WO PCT/CN2021/103358 patent/WO2022002097A1/zh active Application Filing
- 2021-06-30 CN CN202180047203.4A patent/CN115989230A/zh active Pending
Also Published As
Publication number | Publication date |
---|---|
CN113880865A (zh) | 2022-01-04 |
WO2022002097A1 (zh) | 2022-01-06 |
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