CN115970140B - Drug delivery device - Google Patents

Drug delivery device Download PDF

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Publication number
CN115970140B
CN115970140B CN202310244390.6A CN202310244390A CN115970140B CN 115970140 B CN115970140 B CN 115970140B CN 202310244390 A CN202310244390 A CN 202310244390A CN 115970140 B CN115970140 B CN 115970140B
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China
Prior art keywords
tube
pushing
guide wire
delivery device
drug delivery
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CN202310244390.6A
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CN115970140A (en
Inventor
胡佩
罗敏
张潇
葛杰
何丽霞
董立平
张子然
刘鑫
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Second Medical Center of PLA General Hospital
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Second Medical Center of PLA General Hospital
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Publication of CN115970140A publication Critical patent/CN115970140A/en
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    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02ATECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Abstract

The invention discloses a drug delivery device, which comprises a gastric tube, wherein the gastric tube comprises a body inner end and an outer end, the body inner end is one end of the gastric tube extending into a patient, and the outer end is one end of the gastric tube arranged outside the patient; a pushing assembly for pushing a desired medication through the gastric tube into the patient; the storage component is connected with the pushing component and is used for temporarily storing granular medicines; a notch for realizing drug dissolution or leakage is arranged on the storage component; when the stomach tube is specifically used, the stomach tube is firstly conveyed to the body of a patient, then the pushing assembly is connected with the storage assembly, medicines are filled in the storage assembly and are placed in the stomach tube, pushing is carried out through the pushing assembly, the pushing assembly and the storage assembly are pulled out after the medicine conveying is finished, and the stomach tube can be retained in the body of the patient for conveying next time.

Description

Drug delivery device
Technical Field
The invention belongs to the technical field of medical appliances, and particularly relates to a drug delivery device.
Background
Some critical patients, such as parkinsonian patients, have dysphagia and need to be left with gastric tubes, but some drugs for treating parkinsonism, such as sustained release tablets or controlled release tablets, are not clinically recommended to be taken by grinding, the continuous curative effect of the drugs is destroyed by grinding, and the tablets cannot be delivered. Accordingly, the present invention addresses the above-described problems by providing a drug delivery device.
Disclosure of Invention
In order to overcome the problems in the background art, the invention is characterized in that granular medicines are placed in a storage component and are sent into corresponding human body cavities through a pushing component connected with the storage component, and the slow release of the medicines is mainly finished by sending the granular medicines into the stomach through a stomach tube; the technical scheme is as follows:
a drug delivery device comprising
The stomach tube comprises a body inner end and an outer end, wherein the body inner end is the end of the stomach tube extending into the body of a patient, and the outer end is the end of the stomach tube arranged outside the patient;
a pushing assembly for pushing a desired medication through the gastric tube into the patient;
the storage component is connected with the pushing component and is used for temporarily storing granular medicines; a notch for realizing drug dissolution or leakage is arranged on the storage component; when the stomach tube is specifically used, the stomach tube is firstly conveyed to the body of a patient, then the pushing assembly is connected with the storage assembly, medicines are filled in the storage assembly and are placed in the stomach tube, pushing is carried out through the pushing assembly, the pushing assembly and the storage assembly are pulled out after the medicine conveying is finished, and the stomach tube can be retained in the body of the patient for conveying next time.
In some embodiments of the present application, the pushing assembly includes a first guide wire, a pushing tube and a locking component, a moving hole is formed on the pushing tube, one end of the first guide wire is connected with the storage assembly, the other end of the first guide wire penetrates through the moving hole, and the first guide wire is movably connected with the locking component; the locking component is located at one end of the pushing tube, which is arranged outside the patient, one end of the locking component is connected with the pushing tube, and the other end of the locking component is connected with the first guide wire.
Further, the locking part comprises a clamping jaw and a torsion spring, a fixed rod is arranged on the pushing tube and penetrates through the clamping jaw and the torsion spring, two ends of the fixed rod are connected with the pushing tube, one end of the torsion spring is connected with the clamping jaw, and the other end of the torsion spring is connected with the pushing tube.
Further, the storage assembly comprises a first clamping piece, a second clamping piece and basket strips, wherein two ends of the basket strips are respectively connected with the first clamping piece and the second clamping piece, at least two basket strips are arranged, preferably four basket strips are arranged; the first clamping piece is connected with the first guide wire; the pushing tube is provided with a placing cavity which is communicated with the moving hole, and the clamping piece I, the clamping piece II, the basket strips and the first guide wires are movably connected with the placing cavity.
Further, the diameter of the first clamping piece is larger than that of the second clamping piece, a limiting ring is arranged in the placing cavity and used for limiting the position of the first clamping piece and preventing the first clamping piece from being separated from the placing cavity.
Further, the inner diameter of the limiting ring is larger than the diameter of the clamping piece II, and the inner diameter of the limiting ring is smaller than the diameter of the clamping piece I.
Further, the internal end of stomach tube is equipped with the tube head, be equipped with the second through-hole on the tube head, the tube head with the internal end is connected, the second through-hole is used for through storage component and first seal wire to make storage component can release the medicine.
Further, the inside wall of tube head begins from tube head and the internal end junction, and the diameter of the inside wall of tube head is progressively decreased, and after this kind of setting can guarantee that push tube got into the tube head, push tube's orificial center can be collinearly with the central axis of second through-hole, and then is favorable to carrying storage component to release the medicine.
The invention has the beneficial effects that: compared with the existing drug delivery device, the technical scheme of the invention realizes that the drug is delivered to the body of a patient under the condition that the original specification of the drug is not destroyed by arranging the gastric tube, the pushing component and the storage component, thereby maintaining the continuous curative effect of the drug.
Drawings
FIG. 1 is a schematic diagram of the overall structure of the present invention;
FIG. 2 is a schematic view of the gastric tube, push tube and first guide wire structure of the present invention;
FIG. 3 is a schematic view of the structure of the gastric tube, push tube, first guide wire and locking member of the present invention;
FIG. 4 is a schematic view of the structure of the locking member of the present invention;
FIG. 5 is a schematic view of a clamping jaw structure according to the present invention;
FIG. 6 is a schematic view of the structure of the clamping jaw, torsion spring and clamping groove of the present invention;
FIG. 7 is a schematic view of the internal end structure of the present invention;
FIG. 8 is a schematic diagram of a memory assembly according to the present invention;
FIG. 9 is a schematic diagram of an expanded configuration of a storage assembly according to the present invention;
FIG. 10 is a cross-sectional view of the inner end of the gastric tube and tube head of the present invention;
FIG. 11 is a schematic view of a push tube structure according to the present invention;
FIG. 12 is a cross-sectional view of a gastric tube, push tube and storage assembly of the present invention;
in the figure, 1, a stomach tube; 11. a blocking member; 12. a tube head; 121. a second through hole; 13. a side hole; 2. a first guidewire; 21. basket strips; 22. a second clamping piece; 23. a clamping piece I; 3. a pushing tube; 31. a clamping jaw; 311. a torsion spring; 312. an anti-slip pad; 32. a moving hole; 33. a placement cavity; 34. and a limiting ring.
Detailed Description
The following detailed description of the embodiments of the present invention will be made more apparent to those skilled in the art from the following detailed description, in which the invention is embodied in several, but not all, embodiments of the invention. The invention may be embodied or applied in other specific forms and features of the following examples and examples may be combined with each other without conflict, all other examples being contemplated by those of ordinary skill in the art without undue burden from the present disclosure, based on the examples of the invention.
Fig. 1 shows the main technical content of the present embodiment, which provides a drug delivery device comprising
The stomach tube 1 comprises a body inner end and an outer end, wherein the body inner end is the end of the stomach tube 1 extending into the body of a patient, and the outer end is the end of the stomach tube 1 arranged outside the patient;
a pushing assembly for pushing a desired drug into a patient through the gastric tube 1; comprising the following steps:
a storage assembly for temporarily storing the medicament; a notch for realizing drug dissolution or leakage is arranged on the storage component;
the pushing component is connected with the storage component and used for pushing the storage component to the stomach of a patient through the stomach tube 1. When the stomach tube is specifically used, the stomach tube 1 is firstly placed in a patient, then the medicine is placed in the storage component to be fixed, then the storage component is pushed to the internal end of the stomach tube 1 through the pushing component, and the medicine is released through the storage component.
Referring to fig. 2 to 11, in this embodiment, the pushing assembly includes a first guide wire 2, a pushing tube 3 and a locking component, a moving hole 32 is provided on the pushing tube 3, the first guide wire 2 is movably connected with the moving hole 32, one end of the first guide wire 2 is connected with the storage assembly, the other end of the first guide wire 2 penetrates through the moving hole 32, and the first guide wire 2 is movably connected with the locking component; the locking part is located the external one end of pushing tube 3 arranging in the patient, and locking part's one end is connected with pushing tube 3, and locking part's the other end is connected with first seal wire 2.
Referring to fig. 3-6, the locking component in this embodiment includes a clamping jaw 31 and a torsion spring 311, a fixing rod is disposed on the pushing tube 3, the fixing rod penetrates through the clamping jaw 31 and the torsion spring 311, two ends of the fixing rod are connected with the pushing tube 3, one end of the torsion spring 311 is connected with the clamping jaw 31, and the other end of the torsion spring 311 is connected with the pushing tube 3. The clamping jaw 31 is provided with a clamping groove which is a cylindrical groove body attached to the first guide wire 2; the clamping groove is internally provided with an anti-slip pad 312, one end of the anti-slip pad 312 is connected with the clamping groove, and the other end of the anti-slip pad 312 is detachably connected with the first guide wire 2. The clamping groove is separated from the first guide wire 2 by pressing the clamping jaw 31, and the first guide wire 2 is moved, so that the storage component is driven to move, and the medicine is released.
In another embodiment, the locking component comprises a chuck body, a claw and a driving structure, wherein the chuck body is connected with one end of the pushing tube 3, which is positioned outside the patient body, the claw part is positioned inside the chuck body, the claw is connected with the chuck body, the driving structure part is positioned inside the chuck body, one end of the driving structure is connected with the claw, and the other end of the driving structure is movably connected with the chuck body; the chuck body is provided with a first through hole, the first guide wire 2 penetrates through the first through hole, and the first guide wire 2 is movably connected with the clamping jaw and the chuck body; the driving structure can drive the clamping jaw to move on the chuck body, and the movement of the first guide wire 2 in the pushing tube 3 is controlled through the movement of the clamping jaw. The claws are distributed in a circumferential array along the edge of the first through hole.
The claw is provided with at least two.
Preferably, three claws are provided.
The chuck body is provided with a rectangular hole, the claw penetrates through the rectangular hole, and the claw is movably connected with the rectangular hole. The rectangular holes are arranged so as to limit the movement of the clamping jaws, so that the clamping jaws can only realize relative linear movement on the chuck body. The drive structure includes first bevel gear and second bevel gear, is equipped with the handle on the second bevel gear, and the handle is connected with the second bevel gear for rotate the second bevel gear, the handle runs through the chuck body, and the handle rotates with the chuck body to be connected, and first bevel gear and second bevel gear all are located the inside of the chuck body, and first bevel gear and second bevel gear meshing are equipped with the removal groove on the first bevel gear, and the removal groove sets up to rectangular structure, jack catch and removal groove swing joint, and the removal groove sets up at least three. The second bevel gear is driven to rotate through the rotating handle, so that the first bevel gear rotates, and the claw achieves relative linear motion relative to the central axis of the first through hole through the cooperation of the rectangular hole and the moving groove.
Referring to fig. 6 to 12, in the present embodiment, the storage assembly includes a first clamping member 23, a second clamping member 22, and basket strips 21, two ends of the basket strips 21 are respectively connected to the first clamping member 23 and the second clamping member 22, at least two basket strips 21 are provided, and the first clamping member 23 is connected to the first guide wire 2; the pushing tube 3 is provided with a placing cavity 33, the placing cavity 33 is communicated with the moving hole 32, and the clamping piece I23, the clamping piece II 22, the basket strips 21 and the first guide wires 2 are movably connected with the placing cavity 33. The diameter of the first clamping piece 23 is larger than that of the second clamping piece 22, a limiting ring 34 is arranged in the placing cavity 33, and the limiting ring 34 is used for limiting the position of the first clamping piece 23 and preventing the first clamping piece 23 from being separated from the placing cavity 33. The inner diameter of the limiting ring 34 is larger than the diameter of the clamping piece II 22, and the inner diameter of the limiting ring 34 is smaller than the diameter of the clamping piece I23. The storage component is a self-expanding storage component, the basket strips 21 are made of memory metal materials, and the self-expanding storage component can realize self expansion after the storage component extends out of the stomach tube 1. The storage component is in a spindle shape after self-expansion; this shape arrangement allows the drug to enter the stomach from the storage assembly through the gaps between the basket strips 21 in the best expanded state.
Referring to fig. 12, in another embodiment, the storage assembly includes a cylindrical structure with a receiving cavity, with a hole-shaped indentation provided in a wall of the cylindrical structure. The storage component in this way is simple to set up. Alternatively, the storage assembly comprises a self-expanding structure capable of self-expanding after extending from the gastric tube 1, the self-expanding structure being supported by a plurality of memory metal strips; forming a gap after self-expanding of the self-expanding structure for leakage of the medicine; the external diameter of the storage component is consistent with the internal diameter of the stomach tube 1, and the arrangement can effectively avoid uncontrolled leakage or sliding of the medicine in the pushing process. Alternatively, the device further comprises a push tube 3 for avoiding leakage of the drug from the push tube 3; is arranged outside the storage component, and the outer diameter of the storage component is equal to the inner diameter of the pushing tube 3. Through the arrangement of the pushing tube 3, the effective control of the dosage before entering the stomach tube 1 can be well realized, and the problem of inaccurate dosage caused by losing the medicine in the process is avoided.
Preferably, the basket strips 21 are provided with four.
Referring to fig. 11-12, in this embodiment, a first placing groove is formed in a first clamping member 23, a second placing groove is formed in a second clamping member 22, the first placing groove and the second placing groove are used for placing a required medicine, when the drug delivery device is specifically used, the required medicine is placed between the first clamping member 23 and the second clamping member 22, the first wire 2 is pulled to enable the first clamping member 23 to move, so that the mesh basket strip 21 is driven to shrink to restrain the medicine, the second clamping member 22 is used for blocking, the medicine is located in the placing cavity 33, and the push tube 3 is integrally placed in the stomach tube 1 for drug delivery.
The aperture of the moving bore 32 is larger than the diameter of the first guide wire 2.
Preferably, the aperture of the moving hole 32 is set to 0.37mm.
Referring to fig. 10-12, the inner end of the gastric tube 1 is provided with a tube head 12, the tube head 12 is provided with a semicircular structure, the tube head 12 is provided with a second through hole 121, the tube head 12 is connected with the inner end, and the second through hole 121 is used for passing through the storage component and the first guide wire 2, so that the storage component can release medicines.
The inside wall of tube head 12 begins from tube head 12 and the internal end junction, and the diameter progressively decreases, and this kind of setting can guarantee push tube 3 get into after tube head 12, push tube 3's orificial center can be collinearly with the central axis of second through-hole 121, and then is favorable to carrying storage module to release the medicine.
The inner end of the body is provided with a side hole 13, and at least one side hole 13 is arranged.
Preferably, the side holes 13 are provided with six.
In another embodiment, the storage assembly comprises a locking member, a holding jaw and a fixing member, one end of the fixing member is connected with the first guide wire 2, the other end of the fixing member is connected with the holding jaw, the locking member is located between the holding jaw and the placing cavity 33, and the locking member can control opening and closing of the holding jaw, so that the holding jaw can release medicine. The clamping claw is provided with at least two.
Preferably, the holding claws are provided with four.
Preferably, the holding claws are made of a memory alloy material.
The retaining member is set to be regular prism structure, place the chamber 33 and the structure coincide with the retaining member, this kind of setting can guarantee that the retaining member can only carry out relative rectilinear movement in placing the chamber 33, can not carry out relative rotation, be equipped with the locking groove on the retaining member, be equipped with the screw thread section on the mounting, screw thread section and locking groove threaded connection, during specific use, remove first seal wire 2 and make the gripper shift out stomach tube 1, rotate first seal wire 2 afterwards, first seal wire 2 drives the mounting and rotates, the mounting removes and drives the gripper and remove, the gripper breaks away from the retaining member, release the medicine under elastic effect.
Referring to fig. 7, in this embodiment, the gastric tube 1 includes a second guide wire, on which a pushing member is provided, the pushing member is connected with the second guide wire, the second guide wire is used for conveying the gastric tube 1, the diameter of the pushing member is larger than the diameter of the second through hole 121 on the tube head 12, and when in specific use, one end with the pushing member on the second guide wire is firstly placed inside the gastric tube 1, the gastric tube 1 is conveyed into a patient, and the guide wire is taken out.
The instrument disclosed by the invention can be also used for any other body cavity or artificial cavity, and comprises the pushing assembly, wherein the pushing tube with the same length is arranged outside the pushing assembly, the length of the pushing tube is consistent with that of the pushing assembly, and the inner diameter of the pushing tube is consistent with that of the storage unit. The related human body cavity comprises esophagus, vagina, urethra, minimally invasive surgery channel, constructed drainage channel and the like.
Referring to fig. 1-12, the method of use and the principle of operation of the present invention: when the medical device is specifically used, firstly, one end of the second guide wire with the pushing piece is placed in the stomach tube 1, the stomach tube 1 is conveyed into a patient, then the second guide wire is taken out, when the medical device is required to be conveyed to the patient, the clamping jaw 31 is pinched firstly to move the first guide wire 2 towards the direction close to the clamping jaw 31, so that the clamping piece I23, the clamping piece II 22 and the basket strip 21 move out of the placing cavity 33, the required medical device is filled between the clamping piece I23, the clamping piece II 22 and the basket strip 21, the clamping jaw 31 is pressed, the first guide wire 2 is moved in the opposite direction, the clamping piece I23, the clamping piece II 22 and the basket strip 21 are retracted into the placing cavity 33, then the pushing tube 3 is placed in the stomach tube 1 for conveying, after the medical device is conveyed into the patient, the position is determined according to the lengths of the stomach tube 1 and the pushing tube 3, the clamping jaw 31 is pinched to move the first guide wire 2 towards the direction close to the clamping jaw 31, so that the clamping piece I23, the clamping piece II 22 and the basket strip 21 move out of the placing cavity 33, and the medical device is released.
The foregoing has shown and described the basic principles, principal features and advantages of the invention. It will be understood by those skilled in the art that the present invention is not limited to the above-described embodiments, and that the above-described embodiments and descriptions are only preferred embodiments of the present invention, and are not intended to limit the invention, and that various changes and modifications may be made therein without departing from the spirit and scope of the invention as claimed. The scope of the invention is defined by the appended claims and equivalents thereof.

Claims (10)

1. A drug delivery device, comprising:
the stomach tube comprises a body inner end and an outer end, wherein the body inner end is the end of the stomach tube extending into the body of a patient, and the outer end is the end of the stomach tube arranged outside the patient;
a pushing assembly for pushing a desired medication through the gastric tube into the patient;
the storage component is connected with the pushing component and is used for temporarily storing granular medicines; a notch for realizing drug dissolution or leakage is arranged on the storage component;
the pushing assembly comprises a first guide wire, a pushing tube and a locking part, wherein a moving hole is formed in the pushing tube, and one end of the first guide wire is connected with the storage assembly;
the storage assembly comprises a clamping piece I, a clamping piece II and basket strips, wherein two ends of the basket strips are respectively connected with the clamping piece I and the clamping piece II, and at least two basket strips are arranged; the first clamping piece is connected with the first guide wire; the pushing tube is provided with a placing cavity which is communicated with the moving hole, and the clamping piece I, the clamping piece II, the basket strips and the first guide wires are movably connected with the placing cavity.
2. The drug delivery device of claim 1, wherein the other end of the first guidewire extends through the movement aperture, the first guidewire being movably coupled to the locking member; the locking component is located at one end of the pushing tube, which is arranged outside the patient, one end of the locking component is connected with the pushing tube, and the other end of the locking component is connected with the first guide wire.
3. The drug delivery device according to claim 2, wherein the locking member comprises a clamping jaw and a torsion spring, a fixing rod is arranged on the push tube, the fixing rod penetrates through the clamping jaw and the torsion spring, two ends of the fixing rod are connected with the push tube, one end of the torsion spring is connected with the clamping jaw, and the other end of the torsion spring is connected with the push tube.
4. A drug delivery device according to claim 2, wherein the basket strips are provided with four.
5. The drug delivery device of claim 4, wherein the first clamping member has a diameter greater than the second clamping member, and wherein a stop ring is disposed in the placement cavity, the stop ring being configured to position the first clamping member to prevent the first clamping member from being removed from the placement cavity.
6. The drug delivery device of claim 5, wherein the stop collar has an inner diameter greater than the diameter of the second clamp member and an inner diameter less than the diameter of the first clamp member.
7. The drug delivery device of any one of claims 1-6, wherein the gastric tube is provided with a tube head at an inner end thereof, the tube head being provided with a second through-hole, the tube head being connected to the inner end thereof, the second through-hole being for passing through the storage assembly and the first guide wire, thereby enabling the storage assembly to release the drug.
8. The drug delivery device of claim 7, wherein the inner sidewall of the cartridge is tapered in diameter from the junction of the cartridge and the inner end.
9. The drug delivery device of claim 8, wherein the gastric tube comprises a second guide wire, a pushing member is arranged on the second guide wire, the pushing member is connected with the second guide wire, and the second guide wire is used for delivering the gastric tube.
10. A drug delivery device as in claim 9, wherein the diameter of the pushing member is larger than the diameter of the second through hole in the tube head.
CN202310244390.6A 2023-03-15 2023-03-15 Drug delivery device Active CN115970140B (en)

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CN115970140B true CN115970140B (en) 2023-06-30

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Citations (2)

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Publication number Priority date Publication date Assignee Title
CN110123645A (en) * 2019-05-20 2019-08-16 青岛市妇女儿童医院(青岛市妇幼保健院、青岛市残疾儿童医疗康复中心、青岛市新生儿疾病筛查中心) A kind of stomach tube of built-in auxiliary guide
CN211272476U (en) * 2019-12-03 2020-08-18 重庆市人民医院 Guide wire stomach tube

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US8388573B1 (en) * 2006-06-28 2013-03-05 Abbott Cardiovascular Systems Inc. Local delivery with a balloon covered by a cage
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CN213098552U (en) * 2020-06-28 2021-05-04 郑州蓝跃生物科技股份有限公司 Support conveying device
CN115645716A (en) * 2022-10-27 2023-01-31 金华市人民医院 Ureter soft mirror seal wire fixation clamp

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Publication number Priority date Publication date Assignee Title
CN110123645A (en) * 2019-05-20 2019-08-16 青岛市妇女儿童医院(青岛市妇幼保健院、青岛市残疾儿童医疗康复中心、青岛市新生儿疾病筛查中心) A kind of stomach tube of built-in auxiliary guide
CN211272476U (en) * 2019-12-03 2020-08-18 重庆市人民医院 Guide wire stomach tube

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