CN115970140A

CN115970140A - Drug delivery device

Info

Publication number: CN115970140A
Application number: CN202310244390.6A
Authority: CN
Inventors: 胡佩; 罗敏; 张涕; 葛杰; 何丽霞; 董立平; 张子然; 刘鑫
Original assignee: Second Medical Center of PLA General Hospital
Current assignee: Second Medical Center of PLA General Hospital
Priority date: 2023-03-15
Filing date: 2023-03-15
Publication date: 2023-04-18
Anticipated expiration: 2043-03-15
Also published as: CN115970140B

Abstract

The invention discloses a drug delivery device, which comprises a gastric tube, wherein the gastric tube comprises an inner end and an outer end, the inner end is the end of the gastric tube extending into a patient, and the outer end is the end of the gastric tube arranged outside the patient; the pushing assembly is used for pushing the required medicine into the body of the patient through a gastric tube; the storage component is connected with the pushing component and temporarily stores the granular medicines; a notch for realizing the dissolution or leakage of the medicine is arranged on the storage component; during specific use, carry the stomach tube earlier and be connected propelling movement subassembly and storage module to the patient after internal, with packing into the medicine in the storage module and arranging the stomach tube in, carry out the propelling movement through the propelling movement subassembly, take propelling movement subassembly and storage module out after the medicine is carried and is accomplished, the stomach tube can be detained and carry out next time at the patient internal transport.

Description

Drug delivery device

Technical Field

The invention belongs to the technical field of medical instruments, and particularly relates to a drug delivery device.

Background

At present, some critical patients, such as Parkinson patients, have swallowing disorder and need to be provided with an indwelling gastric tube, but some drugs for treating Parkinson, such as sustained-release tablets or moisture-control tablets, are not clinically recommended to be taken by grinding, which can destroy the continuous curative effect of the drugs, but the tablets cannot be delivered. The present invention is therefore directed to the above-mentioned problem, and provides a drug delivery device.

Disclosure of Invention

In order to overcome the problems in the background art, the granular medicines are placed in a storage component, are sent into the corresponding human body cavity through a pushing component connected with the storage component, and are mainly sent into the stomach through a stomach tube to complete the slow release of the medicines; the technical scheme is as follows:

a drug delivery device comprising

The stomach tube comprises an inner end and an outer end, the inner end is the end of the stomach tube extending into the body of a patient, and the outer end is the end of the stomach tube arranged outside the body of the patient;

the pushing assembly is used for pushing the required medicine into the body of the patient through a gastric tube;

the storage component is connected with the pushing component and temporarily stores the granular medicines; a notch for realizing the dissolution or leakage of the medicine is arranged on the storage component; during specific use, carry the stomach tube earlier and be connected propelling movement subassembly and storage module to the patient after internal, with packing into the medicine in the storage module and arranging the stomach tube in, carry out the propelling movement through the propelling movement subassembly, take propelling movement subassembly and storage module out after the medicine is carried and is accomplished, the stomach tube can be detained and carry out next time at the patient internal transport.

In some embodiments of the present application, the pushing assembly includes a first guide wire, a pushing tube and a locking component, the pushing tube is provided with a moving hole, one end of the first guide wire is connected to the storage assembly, the other end of the first guide wire penetrates through the moving hole, and the first guide wire is movably connected to the locking component; the locking component is positioned at one end of the pushing tube, which is arranged outside the patient body, one end of the locking component is connected with the pushing tube, and the other end of the locking component is connected with the first guide wire.

Further, the locking part includes clamping jaw and torsional spring, be equipped with the dead lever on the propelling movement pipe, the dead lever runs through clamping jaw and torsional spring, the both ends of dead lever all with the propelling movement pipe is connected, the one end of torsional spring with the clamping jaw is connected, the other end of torsional spring with the propelling movement pipe is connected.

Further, the storage assembly comprises a first clamping piece, a second clamping piece and basket strips, two ends of each basket strip are respectively connected with the first clamping piece and the second clamping piece, at least two basket strips are arranged, and preferably four basket strips are arranged; the first clamping piece is connected with the first guide wire; the push pipe is provided with a placing cavity, the placing cavity is communicated with the moving hole, and the first clamping piece, the second clamping piece, the net basket strip and the first guide wire are all movably connected with the placing cavity.

Further, the diameter of the first clamping piece is larger than that of the second clamping piece, a limiting ring is arranged in the moving cavity and used for limiting the position of the first clamping piece, and the first clamping piece is prevented from being separated from the placing cavity.

Further, the inner diameter of the limiting ring is larger than the diameter of the clamping piece II, and the inner diameter of the limiting ring is smaller than the diameter of the clamping piece I.

Further, the internal end of stomach tube is equipped with the tube head, be equipped with the second through-hole on the tube head, the tube head with internal end is connected, the second through-hole is used for passing through storage component and first seal wire to make storage component can release the medicine.

Further, the inside wall of tube head begins from tube head and internal end junction, and the diameter of the inside wall of tube head descends step by step, and this kind of setting can guarantee that the propelling movement pipe gets into the tube head after, the orificial center of propelling movement pipe can with the central axis collineation of second through-hole, and then be favorable to carrying the storage assembly to release the medicine.

The invention has the beneficial effects that: compared with the existing drug delivery device, the technical scheme provided by the invention has the advantages that the drug is delivered into the body of a patient under the condition that the original specification of the drug is not damaged by arranging the gastric tube, the pushing assembly and the storage assembly, and the continuous curative effect of the drug is further maintained.

Drawings

FIG. 1 is a schematic view of the overall structure of the present invention;

FIG. 2 is a schematic view of a gastric tube, a pusher tube and a first guide wire according to the present invention;

FIG. 3 is a schematic structural view of a gastric tube, a push tube, a first guide wire and a locking member according to the present invention;

FIG. 4 is a schematic view of the locking assembly of the present invention;

FIG. 5 is a schematic view of a jaw configuration of the present invention;

FIG. 6 is a schematic view of the structure of the clamping jaw, the torsion spring and the clamping groove of the present invention;

FIG. 7 is a schematic illustration of a body-inside structure of the present invention;

FIG. 8 is a schematic diagram of a memory device according to the present invention;

FIG. 9 is a schematic view of an expanded configuration of the storage assembly of the present invention;

FIG. 10 is a cross-sectional view of the inner end of the gastric tube and tube head of the present invention;

FIG. 11 is a schematic view of a pusher tube configuration according to the present invention;

FIG. 12 is a cross-sectional view of a gastric tube, pusher tube and storage assembly of the present invention;

in the figure, 1, a stomach tube; 11. a blocking member; 12. a tube head; 121. a second through hole; 13. a side hole; 2. a first guide wire; 21. a basket strip; 22. a second clamping piece; 23. a first clamping piece; 3. pushing the pipe; 31. a clamping jaw; 311. a torsion spring; 312. a non-slip mat; 32. moving the hole; 33. a placement chamber; 34. a limit ring.

Detailed Description

The technical solutions in the embodiments of the present invention are clearly and completely described below by specific embodiments, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, rather than all embodiments, and other advantages and effects of the present invention can be easily understood by those skilled in the art from the disclosure of the present specification. The present invention can be implemented or applied by other different specific embodiments, and the features in the following embodiments and embodiments can be combined with each other without conflict, and all other embodiments obtained by a person of ordinary skill in the art without creative efforts based on the embodiments of the present invention belong to the protection scope of the present invention.

Fig. 1 shows the main technical content of the present embodiment, which provides a drug delivery device comprising

The stomach tube 1 comprises an inner end and an outer end, the inner end is the end of the stomach tube 1 extending into the body of a patient, and the outer end is the end of the stomach tube 1 arranged outside the body of the patient;

the pushing assembly is used for pushing the required medicine into the body of the patient through the gastric tube 1; the method comprises the following steps:

a storage assembly for temporarily storing the medicament; a notch for realizing the dissolution or leakage of the medicine is arranged on the storage component;

the pushing assembly is connected with the storage assembly and used for pushing the storage assembly to the stomach of the patient through the stomach tube 1. During the specific use, at first put into patient with stomach tube 1 internal, then place the medicine and fix in storage component, later through the propelling movement subassembly with storage component propelling movement to stomach tube 1 internal end, release the medicine through storage component.

Referring to fig. 2 to 11, in this embodiment, the pushing assembly includes a first guide wire 2, a pushing tube 3 and a locking component, the pushing tube 3 is provided with a moving hole 32, the first guide wire 2 is movably connected with the moving hole 32, one end of the first guide wire 2 is connected with the storage assembly, the other end of the first guide wire 2 penetrates through the moving hole 32, and the first guide wire 2 is movably connected with the locking component; the locking component is positioned at one end of the pushing tube 3, which is arranged outside the patient body, one end of the locking component is connected with the pushing tube 3, and the other end of the locking component is connected with the first guide wire 2.

Referring to fig. 3 to 6, the locking component in this embodiment includes a clamping jaw 31 and a torsion spring 311, a fixing rod is disposed on the push tube 3, the fixing rod penetrates through the clamping jaw 31 and the torsion spring 311, two ends of the fixing rod are connected to the push tube 3, one end of the torsion spring 311 is connected to the clamping jaw 31, and the other end of the torsion spring 311 is connected to the push tube 3. A clamping groove is arranged on the clamping jaw 31 and is a cylindrical groove body attached to the first guide wire 2; be equipped with the slipmat 312 in the centre gripping groove, the one end and the centre gripping groove of slipmat 312 are connected, and the other end and the first seal wire 2 of slipmat 312 can be dismantled and be connected. Make centre gripping groove and first seal wire 2 separation through pressing clamping jaw 31, remove first seal wire 2 to drive storage component and remove, and then release the medicine.

In another embodiment, the locking component comprises a chuck body, a clamping jaw and a driving structure, the chuck body is connected with one end of the pushing pipe 3, which is positioned outside the patient, the clamping jaw part is positioned inside the chuck body, the clamping jaw is connected with the chuck body, the driving structure part is positioned inside the chuck body, one end of the driving structure is connected with the clamping jaw, and the other end of the driving structure is movably connected with the chuck body; a first through hole is formed in the chuck body, the first guide wire 2 penetrates through the first through hole, and the first guide wire 2 is movably connected with the clamping jaw and the chuck body; the driving structure can drive the clamping jaw to move on the chuck body, and the first guide wire 2 is controlled to move in the push pipe 3 through the movement of the clamping jaw. The clamping jaws are distributed along the edge of the first through hole in a circumferential array.

The claw sets up two at least.

Preferably, three claws are provided.

The chuck body is provided with a rectangular hole, the clamping jaw penetrates through the rectangular hole, and the clamping jaw is movably connected with the rectangular hole. The rectangular holes are formed so as to limit the movement of the clamping jaws, so that the clamping jaws can only realize relative linear motion on the chuck body. The driving structure comprises a first bevel gear and a second bevel gear, a handle is arranged on the second bevel gear and is connected with the second bevel gear, the handle is used for rotating the second bevel gear, the handle penetrates through the chuck body and is connected with the chuck body in a rotating mode, the first bevel gear and the second bevel gear are both located inside the chuck body and are meshed with each other, a moving groove is formed in the first bevel gear, the moving groove is of a rectangular structure, clamping jaws are movably connected with the moving groove, and the moving groove is at least three. The handle is rotated to drive the second bevel gear to rotate, so that the first bevel gear rotates, and the jaws realize relative linear motion about the central axis of the first through hole through the matching of the rectangular hole and the moving groove.

Referring to fig. 6 to 12, in the present embodiment, the storage assembly includes a first clamping member 23, a second clamping member 22 and a basket strip 21, two ends of the basket strip 21 are respectively connected to the first clamping member 23 and the second clamping member 22, at least two basket strips 21 are provided, and the first clamping member 23 is connected to the first guide wire 2; the pushing pipe 3 is provided with a placing cavity 33, the placing cavity 33 is communicated with the moving hole 32, and the first clamping piece 23, the second clamping piece 22, the net basket strip 21 and the first guide wire 2 are movably connected with the placing cavity 33. The diameter of the first clamping piece 23 is larger than that of the second clamping piece 22, a limiting ring 34 is arranged in the moving cavity, and the limiting ring 34 is used for limiting the position of the first clamping piece 23 and preventing the first clamping piece 23 from being separated from the placing cavity 33. The inner diameter of the limiting ring 34 is larger than the diameter of the second clamping piece 22, and the inner diameter of the limiting ring 34 is smaller than the diameter of the first clamping piece 23. The storage component is a self-expansion storage component, the basket strips 21 are made of memory metal materials, and self-expansion can be achieved after the basket strips extend out of the stomach tube 1. The storage component is in a spindle shape after self-expansion; this shape arrangement allows the best possible expansion of the medicament from the storage assembly into the stomach through the gap between the basket strips 21.

Referring to fig. 12, in another embodiment, the storage assembly includes a cylindrical structure with a receiving cavity, with a hole-shaped indentation in the cylindrical structure wall. The storage component in the mode is simple in arrangement. Or the storage component comprises a self-expansion structure which can self-expand after extending out of the stomach tube 1, and the self-expansion structure is supported by a plurality of memory metal strips; the self-expanding structure forms a gap after self-expanding for medicine leakage; the outer diameter of the storage component is consistent with the inner diameter of the gastric tube 1, and the arrangement can effectively avoid uncontrolled leakage or sliding of the medicine in the pushing process. Alternatively, the apparatus further comprises a push tube 3 for preventing the drug from leaking out of the push tube 3; is arranged outside the storage assembly and the outer diameter of the storage assembly is equal to the inner diameter of the push tube 3. Through the arrangement of the pushing pipe 3, the effective control of the dosage before entering the stomach tube 1 can be well realized, and the problem of inaccurate dosage caused by medicine loss in the process is avoided.

Preferably, four basket bars 21 are provided.

Referring to 11 to 12, in this embodiment, a first holding groove is formed in the first holding part 23, a second holding groove is formed in the second holding part 22, and the first holding groove and the second holding groove are used for placing a required medicine, when the device is used specifically, the required medicine is placed between the first holding part 23 and the second holding part 22, the first holding part 23 is moved by pulling the first guide wire 2, so that the basket strip 21 is driven to shrink to restrain the medicine, the medicine is blocked by the second holding part 22, the medicine is located in the placing cavity 33, the pushing tube 3 is integrally placed into the stomach tube 1, and medicine conveying is performed.

The bore diameter of the moving hole 32 is larger than the diameter of the first guide wire 2.

Preferably, the hole diameter of the moving hole 32 is set to 0.37mm.

Referring to fig. 10 to 12, a tube head 12 is provided at the inner end of the stomach tube 1, the tube head 12 is configured as a semicircular structure, a second through hole 121 is provided at the tube head 12, the tube head 12 is connected to the inner end of the body, and the second through hole 121 is used for passing through the storage assembly and the first guide wire 2, so that the storage assembly can release the medicine.

The inside wall of tube head 12 begins from tube head 12 and internal end junction, and the diameter decreases progressively step by step, and this kind of setting can guarantee that propelling movement pipe 3 gets into tube head 12 after, the orificial center of propelling movement pipe 3 can be with the central axis collineation of second through-hole 121, and then is favorable to carrying the storage component to release the medicine.

The inner end of the body is provided with at least one side hole 13, and the side holes 13 are arranged.

Preferably, the side holes 13 are provided in six.

In another embodiment, the storage assembly comprises a locking member, a holding jaw and a fixing member, one end of the fixing member is connected with the first guide wire 2, the other end of the fixing member is connected with the holding jaw, the locking member is positioned between the holding jaw and the placing cavity 33, and the locking member can control the opening and closing of the holding jaw, so that the holding jaw can release the medicine. The clamping jaws are provided with at least two.

Preferably, four clamping jaws are provided.

Preferably, the clamping jaw is made of a memory alloy material.

The retaining member sets up to regular prism structure, the structure of placing chamber 33 and is identical with the retaining member, the retaining member can only carry out relative rectilinear movement placing chamber 33 in can be guaranteed in this kind of setting, can not carry out relative rotation, be equipped with the locking groove on the retaining member, be equipped with the screw thread section on the mounting, screw thread section and locking groove threaded connection, during the concrete use, it makes the gripper jaw shift out stomach tube 1 to remove first seal wire 2, later rotate first seal wire 2, first seal wire 2 drives the mounting and rotates, the mounting removes and drives the gripper jaw and remove, the gripper jaw breaks away from the retaining member, release the medicine under elastic effect.

Referring to fig. 7, in this embodiment, the gastric tube 1 includes the second guide wire, and the second guide wire is provided with the pushing member, and the pushing member is connected with the second guide wire, and the second guide wire is used for transporting the gastric tube 1, and the diameter of the pushing member is greater than the diameter of the second through hole 121 on the tube head 12, and during specific use, the one end of the pushing member on the second guide wire is firstly placed inside the gastric tube 1, and the gastric tube 1 is transported to the patient, and the guide wire is taken out.

The device can also be used for any other human body cavity or artificial cavity, and comprises the pushing assembly, wherein the pushing pipe with the same length as the pushing assembly is arranged on the outer side of the pushing assembly, the length of the pushing pipe is the same as that of the pushing assembly, and the inner diameter of the pushing pipe is the same as that of the storage unit. The related human body cavities comprise an esophagus, a vagina, a urethra, a channel for minimally invasive surgery, a constructed drainage channel and the like.

Referring to fig. 1-12, the method of use and the working principle of the present invention: when the medical drug delivery device is used specifically, one end, provided with the pushing piece, of the second guide wire is placed inside the gastric tube 1, the gastric tube 1 is delivered into a patient body, then the second guide wire is taken out, when the drug delivery to the patient is needed, the clamping jaw 31 is firstly pinched to move the first guide wire 2 in the direction close to the clamping jaw 31, so that the first clamping piece 23, the second clamping piece 22 and the basket strip 21 are moved out of the placement cavity 33, the needed drug is filled among the first clamping piece 23, the second clamping piece 22 and the basket strip 21, the clamping jaw 31 is pressed to move the first guide wire 2 in the opposite direction, the first clamping piece 23, the second clamping piece 22 and the basket strip 21 are retracted into the placement cavity 33, then the pushing tube 3 is placed into the gastric tube 1 to be delivered into the patient body, the position is determined according to the lengths of the gastric tube 1 and the pushing tube 3, the clamping jaw 31 is pinched to move the first guide wire 2 in the direction close to the clamping jaw 31, so that the first clamping piece 23, the second clamping piece 22 and the basket strip 21 are moved out of the placement cavity 33, and the drug is released.

The foregoing shows and describes the general principles, essential features, and advantages of the invention. It will be understood by those skilled in the art that the present invention is not limited to the embodiments described above, and the preferred embodiments of the present invention are described in the above embodiments and the description, and are not intended to limit the present invention. The scope of the invention is defined by the appended claims and equivalents thereof.

Claims

1. A drug delivery device, characterized in that it comprises:

the storage component is connected with the pushing component and temporarily stores the granular medicine; the storage component is provided with a notch for realizing the dissolution or leakage of the medicine.

2. The drug delivery device according to claim 1, wherein the pushing assembly comprises a first guide wire, a pushing tube and a locking component, the pushing tube is provided with a moving hole, one end of the first guide wire is connected with the storage assembly, the other end of the first guide wire penetrates through the moving hole, and the first guide wire is movably connected with the locking component; the locking component is positioned at one end of the pushing tube, which is arranged outside the patient body, one end of the locking component is connected with the pushing tube, and the other end of the locking component is connected with the first guide wire.

3. The drug delivery device of claim 2, wherein the locking member comprises a clamping jaw and a torsion spring, the pushing tube is provided with a fixing rod, the fixing rod penetrates through the clamping jaw and the torsion spring, two ends of the fixing rod are connected with the pushing tube, one end of the torsion spring is connected with the clamping jaw, and the other end of the torsion spring is connected with the pushing tube.

4. The drug delivery device of claim 2, wherein the storage assembly comprises a first clamping member, a second clamping member and a basket strip, two ends of the basket strip are respectively connected with the first clamping member and the second clamping member, at least two basket strips are arranged, and preferably four basket strips are arranged; the first clamping piece is connected with the first guide wire; the push pipe is provided with a placing cavity, the placing cavity is communicated with the moving hole, and the first clamping piece, the second clamping piece, the net basket strip and the first guide wire are all movably connected with the placing cavity.

5. The drug delivery device of claim 4, wherein the first clamping member has a diameter larger than that of the second clamping member, and a position limiting ring is disposed in the moving chamber and is used for limiting the position of the first clamping member and preventing the first clamping member from being separated from the placing chamber.

6. The drug delivery device of claim 5, wherein the stop collar has an inner diameter greater than a diameter of the second retaining member and an inner diameter less than a diameter of the first retaining member.

7. A drug delivery device according to any of claims 1-6, wherein a tip is provided at the body end of the gastric tube, said tip being provided with a second through hole, said tip being connected to said body end, said second through hole being adapted to pass through the storage assembly and the first guide wire, thereby enabling the storage assembly to release the drug.

8. The drug delivery device of claim 7, wherein the inner sidewall of the tip has a gradually decreasing diameter from the connection between the tip and the inner end of the body.

9. The drug delivery device of claim 8, wherein the gastric tube comprises a second guide wire, a pusher is disposed on the second guide wire, the pusher is connected with the second guide wire, and the second guide wire is used for delivering the gastric tube.

10. The drug delivery device of claim 9, wherein the pusher has a diameter larger than a diameter of the second through hole in the tip.