CN115969903A - A Chinese medicinal composition, its preparation method, and its application in preparing medicine for preventing and treating fatty liver - Google Patents
A Chinese medicinal composition, its preparation method, and its application in preparing medicine for preventing and treating fatty liver Download PDFInfo
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Abstract
The invention particularly discloses a traditional Chinese medicine composition, a preparation method thereof and application thereof in preparing a medicine with the effect of preventing and treating fatty liver. The traditional Chinese medicine composition comprises the following raw material components: preparing radix et rhizoma Rhei, herba Gynostemmatis, semen Sinapis Albae and Mirabilitum. In addition, the composition also comprises sedum sarmentosum. The traditional Chinese medicine composition is prepared from four traditional Chinese medicines of prepared rhubarb, gynostemma pentaphylla, white mustard seed and mirabilite, and has excellent effects of reducing blood fat and preventing and treating fatty liver. In addition, the sedum sarmentosum is further added into the prepared rhubarb, the gynostemma pentaphylla, the white mustard seed and the mirabilite, so that the blood fat reducing effect and the fatty liver preventing and treating effect of the traditional Chinese medicine composition prepared from the sedum sarmentosum can be obviously improved. Compared with the traditional Chinese medicine for treating fatty liver in the prior art, the traditional Chinese medicine for treating fatty liver is greatly reduced in formula composition, free of precious medicines and toxic medicines, safe, reliable, low in technical risk, wide in market demand and obvious in economic and social benefits.
Description
Technical Field
The invention relates to the technical field of traditional Chinese medicines, in particular to a traditional Chinese medicine composition, a preparation method thereof and application thereof in preparing a medicine with the effect of preventing and treating fatty liver.
Background
Fatty liver refers to a pathological change of liver caused by excessive fat accumulation in liver cells due to various reasons, and is a common pathological change of liver. Fatty liver has various clinical manifestations, mild fatty liver usually has no clinical symptoms, and moderate and severe fatty liver have symptoms similar to chronic hepatitis, such as anorexia, tiredness, hypodynamia, nausea, vomiting, dull pain in the liver area or right upper abdomen, and the like. Mild fatty liver, basically normal liver function. In the middle and severe fatty liver, laboratory examination shows that alanine Aminotransferase (ALT) and aspartate Aminotransferase (AST) are slightly and moderately increased.
Chinese invention patent CN200410061343.5 discloses a Chinese medicine for treating fatty liver, which is composed of black fungus, prepared rhubarb, gynostemma pentaphylla, lotus leaf, ginkgo leaf, aspongopus, fleece-flower root, astragalus root and Chinese angelica. Although the traditional Chinese medicine composition can play a certain role in treating fatty liver, the formula is complex, and nine medicinal materials are required to be used; moreover, the effect is not obvious enough, and the medicine can achieve certain effect after being taken for six months continuously.
The Chinese patent CN02125521.0 discloses a Chinese medicinal preparation for treating fatty liver and obesity, which comprises the following components in part by weight: 3-5 of rhizoma atractylodis; 3-5 of bighead atractylodes rhizome; 3-5 parts of mangnolia officinalis; 3-5 parts of fructus aurantii; 3-5 parts of dried orange peel; 2-4 parts of pinellia ternate; 3-5 parts of platycodon grandiflorum; 2-4 parts of white mustard seed; 4-5 parts of radish seed; 3-5 of rhubarb; 4-5 of rhizoma alismatis; 4-5 parts of hawthorn. It is made up of twelve medicinal materials, and its prescription is very complex.
In summary, most of the existing traditional Chinese medicines for treating fatty liver have the problems of complex formula and insufficient significant effect. Therefore, if the composition for preventing and treating the fatty liver is provided, the composition has a simple formula, and particularly has a simple formula and a remarkable effect, the composition has important application value.
Disclosure of Invention
In order to overcome at least one technical problem in the prior art, the invention provides a traditional Chinese medicine composition.
The technical problem to be solved by the invention is realized by the following technical scheme:
the invention firstly provides a traditional Chinese medicine composition which comprises the following raw material components: preparing radix et rhizoma Rhei, herba Gynostemmatis, semen Sinapis Albae and Mirabilitum.
The inventor surprisingly discovers in a large number of experimental studies that the traditional Chinese medicine composition prepared from four traditional Chinese medicines of rhubarb, gynostemma pentaphylla, semen brassicae and mirabilite has certain effects of reducing blood fat and preventing and treating fatty liver. Compared with the traditional Chinese medicine for treating fatty liver in the prior art, the traditional Chinese medicine for treating fatty liver is greatly reduced in formula composition, free of precious medicines and toxic medicines, safe, reliable, low in technical risk, wide in market demand and obvious in economic and social benefits.
The inventor needs to emphasize that the composition prepared from any one of rhubarb, gynostemma pentaphylla, semen brassicae and mirabilite is not enough, and the effect of reducing blood fat and preventing and treating fatty liver is obviously reduced.
In addition, the inventor also surprisingly discovers that the traditional Chinese medicine composition prepared from four traditional Chinese medicines of prepared rhubarb, gynostemma pentaphylla, semen brassicae and mirabilite also has a certain anti-liver cancer effect.
Preferably, the traditional Chinese medicine composition comprises the following raw material components in parts by weight: 25-35 parts of prepared rhubarb; 10-20 parts of gynostemma pentaphylla; 5-10 parts of white mustard seed; 1-3 parts of mirabilite.
Most preferably, the traditional Chinese medicine composition comprises the following raw material components in parts by weight: 30 parts of prepared rhubarb; 15 parts of gynostemma pentaphylla; 8 parts of white mustard seed; and 2 parts of mirabilite.
Preferably, the composition further comprises sedum sarmentosum.
Preferably, the weight part of the sedum sarmentosum is 10-15 parts.
Most preferably, the weight part of the sedum sarmentosum is 12 parts.
The inventor surprisingly discovers in further research that the effect of reducing blood fat and preventing and treating fatty liver of the traditional Chinese medicine composition prepared by the traditional Chinese medicine composition can be obviously improved by further adding the sedum sarmentosum into the prepared four medicinal materials of rhubarb, gynostemma pentaphylla, semen brassicae and mirabilite.
The inventor needs to emphasize that the effect of reducing blood fat and preventing and treating fatty liver of the traditional Chinese medicine composition prepared by the traditional Chinese medicine composition can be improved or remarkably improved by not adding any traditional Chinese medicine into prepared rhubarb, gynostemma pentaphylla, white mustard seed and mirabilite. A great deal of experimental research shows that the blood fat reducing function and the fatty liver preventing and treating function of the traditional Chinese medicine composition prepared by the inventor can be further obviously improved only by adding the sedum sarmentosum into prepared four medicinal materials of rhubarb, gynostemma pentaphylla, white mustard seed and mirabilite; the addition of other Chinese medicinal materials cannot further improve or remarkably improve the blood fat reducing effect and the fatty liver preventing and treating effect of the Chinese medicinal composition prepared from the Chinese medicinal materials.
In addition, the inventor also surprisingly discovers that the anti-liver cancer effect of the traditional Chinese medicine composition prepared by the traditional Chinese medicine composition can be obviously improved by further adding the sedum sarmentosum into the prepared rhubarb, gynostemma pentaphylla, white mustard seed and Mirabilitum medicinal materials.
The invention also provides a preparation method of the traditional Chinese medicine composition, which comprises the following steps:
(1) Mixing the Chinese medicinal materials including radix et rhizoma Rhei, herba Gynostemmatis, semen Sinapis Albae and/or herba Sedi, and extracting with water to obtain extractive solution;
(2) Adding Mirabilitum into the extractive solution, stirring, concentrating under reduced pressure to remove water to obtain product, and drying to obtain the final product.
Preferably, in the step (1), the weight of the water is 5 to 15 times of the total weight of the prepared rhubarb, the gynostemma pentaphylla, the white mustard seed and/or the sedum sarmentosum;
most preferably, in step (1), the amount of water is 10 times the total weight of the prepared rhubarb, the gynostemma pentaphylla and the mustard seed and/or the sedum sarmentosum.
The invention provides another preparation method of the traditional Chinese medicine composition, which comprises the following steps:
(1) Mixing Chinese medicinal materials including radix et rhizoma Rhei, herba Gynostemmatis, semen Sinapis Albae and/or herba Sedi, and extracting with organic solvent to obtain extractive solution;
(2) Concentrating the extractive solution under reduced pressure to remove organic solvent to obtain product, and drying the product to obtain Chinese medicinal extract;
(3) Suspending the Chinese medicinal extract with water, extracting with chloroform, and separating chloroform layer and water layer;
(4) And (3) taking the water layer, adding mirabilite, uniformly stirring, then carrying out reduced pressure concentration to remove water to obtain a product, and drying the product to obtain the traditional Chinese medicine composition.
Preferably, in the step (1), the weight of the organic solvent is 5-15 of the total weight of the prepared rhubarb, the gynostemma pentaphylla, the white mustard seed and/or the sedum sarmentosum;
most preferably, in step (1), the amount of the organic solvent is 10% by weight of the total weight of the prepared rhubarb, the gynostemma pentaphyllum and the white mustard seed and/or the sedum sarmentosum.
Preferably, the organic solvent is diethyl ether.
The inventor finds that the traditional Chinese medicine composition prepared by organic solvent extraction and extraction treatment has better effects of reducing blood fat and preventing and treating fatty liver than the traditional Chinese medicine composition prepared by water extraction in a large number of experiments.
The inventor needs to emphasize that the selection of organic solvents in the extraction process is very important by taking prepared rhubarb, gynostemma pentaphylla, white mustard seed and/or sedum sarmentosum as raw materials, and the difference between the blood fat reducing effect and the fatty liver preventing and treating effect of the traditional Chinese medicine extract prepared by adopting different organic solvents is huge. The inventor surprisingly discovers in a large number of experiments that in the method, the traditional Chinese medicine extract prepared by using diethyl ether as an organic solvent has the effect of reducing blood fat and preventing and treating fatty liver which is obviously higher than that of a traditional Chinese medicine composition prepared by water extraction; meanwhile, the content of the extract is obviously higher than that of the traditional Chinese medicine extract prepared by other organic solvents. In the method of the present invention, the traditional Chinese medicine extract prepared by other organic solvents has the effects of reducing blood fat and preventing and treating fatty liver, and cannot be greatly improved compared with the traditional Chinese medicine composition prepared by water extraction.
Preferably, the dosage ratio of the traditional Chinese medicine extract to water and chloroform in the step (3) is 1g.
Most preferably, the dosage ratio of the traditional Chinese medicine extract to water and chloroform in the step (3) is 1g.
Preferably, the organic solvent consists of diethyl ether and dimeticone; wherein the volume ratio of the diethyl ether to the dimeticone is 8-10.
Most preferably, the volume ratio of diethyl ether to dimethicone is 9.
The inventor surprisingly finds that the traditional Chinese medicine composition prepared by adding the dimeticone into the diethyl ether and adopting the organic solvent consisting of the diethyl ether and the dimeticone has the effect of reducing the blood fat and preventing and treating the fatty liver which is further greatly higher than the traditional Chinese medicine composition prepared by adopting the diethyl ether alone.
Meanwhile, the inventor also finds that the anti-liver cancer effect of the traditional Chinese medicine composition prepared by adding the dimeticone into the diethyl ether and adopting the organic solvent consisting of the diethyl ether and the dimeticone is also further higher than that of the traditional Chinese medicine composition prepared by adopting the diethyl ether alone.
The invention also provides application of the traditional Chinese medicine composition in preparing a medicine with the function of reducing blood fat.
The invention also provides application of the traditional Chinese medicine composition in preparing a medicine with the effect of preventing and treating fatty liver.
The invention also provides application of the traditional Chinese medicine composition in preparing a medicine with an anticancer effect.
Preferably, the traditional Chinese medicine composition is applied to preparation of medicines with the effects of reducing blood fat and resisting liver cancer.
Preferably, the medicament is in the form of plaster, paste, powder, tablets or capsules.
Has the advantages that: the invention provides a traditional Chinese medicine composition with a brand-new composition; the traditional Chinese medicine composition prepared from four traditional Chinese medicines of prepared rhubarb, gynostemma pentaphylla, white mustard seed and mirabilite has excellent effects of reducing blood fat and preventing and treating fatty liver. In addition, the sedum sarmentosum is further added into the prepared rhubarb, the gynostemma pentaphylla, the white mustard seed and the mirabilite, so that the blood fat reducing effect and the fatty liver preventing and treating effect of the traditional Chinese medicine composition prepared from the sedum sarmentosum can be obviously improved. Compared with the traditional Chinese medicine for treating fatty liver in the prior art, the traditional Chinese medicine for treating fatty liver has the advantages of greatly reduced formula composition, no precious medicine or toxic medicine, safety, reliability, low technical risk, wide market demand and obvious economic and social benefits.
The traditional Chinese medicine composition has the effects of reducing blood fat and treating fatty liver; therefore, the compound is used as an effective component and has important application prospect in preparing medicines with the effects of reducing blood fat and treating fatty liver.
Detailed Description
The present invention is further explained below with reference to examples, which are not intended to limit the present invention in any way.
EXAMPLE 1 preparation of the Chinese medicinal composition
The raw materials comprise the following components in parts by weight: 30 parts of prepared rhubarb; 15 parts of gynostemma pentaphylla; 8 parts of white mustard seed; and 2 parts of mirabilite.
The preparation method comprises the following steps:
(1) Mixing radix et rhizoma Rhei, herba Gynostemmatis and semen Sinapis Albae, adding 10 times of water, heating to boiling state, and reflux-extracting for 1.5 hr to obtain extractive solution;
(2) Adding Mirabilitum into the extractive solution, stirring, concentrating under reduced pressure to remove water to obtain product, and drying to obtain the final product.
EXAMPLE 2 preparation of the Chinese medicinal composition
The raw materials comprise the following components in parts by weight: 30 parts of prepared rhubarb; 15 parts of gynostemma pentaphylla; 8 parts of white mustard seed; 12 parts of stringy stonecrop herb; and 2 parts of mirabilite.
The preparation method comprises the following steps:
(1) Mixing radix et rhizoma Rhei, herba Gynostemmatis, semen Sinapis Albae and herba Sedi, adding 10 times of water, heating to boiling state, and reflux-extracting for 1.5 hr to obtain extractive solution;
(2) Adding Mirabilitum into the extractive solution, stirring, concentrating under reduced pressure to remove water to obtain product, and drying to obtain the final product.
Example 2 compared with example 1, example 2 further added stringy stonecrop herb to the four medicinal materials of prepared rhubarb, gynostemma pentaphylla, white mustard seed and Mirabilitum.
EXAMPLE 3 preparation of the Chinese medicinal composition
The raw materials comprise the following components in parts by weight: 25 parts of prepared rhubarb; 10 parts of gynostemma pentaphylla; 10 parts of white mustard seed; 10 parts of stringy stonecrop herb; 3 parts of mirabilite.
The preparation method comprises the following steps:
(1) Mixing radix et rhizoma Rhei, herba Gynostemmatis, semen Sinapis Albae and herba Sedi, adding 5 times of water, heating to boiling state, and reflux-extracting for 1 hr to obtain extractive solution;
(2) Adding Mirabilitum into the extractive solution, stirring, concentrating under reduced pressure to remove water to obtain product, and drying to obtain the final product.
EXAMPLE 4 preparation of the Chinese medicinal composition
The raw materials comprise the following components in parts by weight: preparing 35 parts of rhubarb; 20 parts of gynostemma pentaphylla; 5 parts of white mustard seed; 15 parts of stringy stonecrop herb; 1 part of mirabilite.
The preparation method comprises the following steps:
(1) Mixing radix et rhizoma Rhei, herba Gynostemmatis, semen Sinapis Albae and herba Sedi, adding 15 times of water, heating to boiling state, and reflux extracting for 2 hr to obtain extractive solution;
(2) Adding Mirabilitum into the extractive solution, stirring, concentrating under reduced pressure to remove water to obtain product, and drying to obtain the final product.
EXAMPLE 5 preparation of the Chinese medicinal composition
The raw materials comprise the following components in parts by weight: 30 parts of prepared rhubarb; 15 parts of gynostemma pentaphylla; 8 parts of white mustard seed; 12 parts of stringy stonecrop herb; and 2 parts of mirabilite.
The preparation method comprises the following steps:
(1) Mixing radix et rhizoma Rhei, herba Gynostemmatis, semen Sinapis Albae and herba Sedi, adding 10 times of organic solvent, heating to boiling state, and reflux-extracting for 1.5 hr to obtain extractive solution;
(2) Concentrating the extractive solution under reduced pressure to remove organic solvent to obtain product, and drying the product to obtain Chinese medicinal extract;
(3) Suspending the Chinese medicinal extract with water, extracting with chloroform, and separating chloroform layer and water layer;
(4) And (3) taking the water layer, adding mirabilite, uniformly stirring, then carrying out reduced pressure concentration to remove water to obtain a product, and drying the product to obtain the traditional Chinese medicine composition.
The organic solvent in the step (1) is diethyl ether;
the dosage ratio of the traditional Chinese medicine extract to water and chloroform in the step (3) is 1g.
Example 5 differs from example 2 in that the preparation described in example 5 employs an organic solvent, diethyl ether extraction; while example 2 was extracted with water.
EXAMPLE 6 preparation of the Chinese medicinal composition
The raw materials comprise the following components in parts by weight: 30 parts of prepared rhubarb; 15 parts of gynostemma pentaphylla; 8 parts of white mustard seed; 12 parts of stringy stonecrop herb; and 2 parts of mirabilite.
The preparation method comprises the following steps:
(1) Mixing radix et rhizoma Rhei, herba Gynostemmatis, semen Sinapis Albae and herba Sedi, adding 10 times of organic solvent, heating to boiling state, and reflux-extracting for 1.5 hr to obtain extractive solution;
(2) Concentrating the extractive solution under reduced pressure to remove organic solvent to obtain product, and drying the product to obtain Chinese medicinal extract;
(3) Suspending the Chinese medicinal extract with water, extracting with chloroform, and separating chloroform layer and water layer;
(4) And (3) taking the water layer, adding mirabilite, uniformly stirring, then carrying out reduced pressure concentration to remove water to obtain a product, and drying the product to obtain the traditional Chinese medicine composition.
The organic solvent in the step (1) consists of diethyl ether and dimeticone in a volume ratio of 9;
the dosage ratio of the traditional Chinese medicine extract to water and chloroform in the step (3) is 1g.
Example 5 differs from example 6 in that the preparation described in example 6 uses an organic solvent consisting of diethyl ether and dimethicone for extraction, whereas example 5 uses diethyl ether for extraction.
Comparative example 1 preparation of a Chinese medicinal composition
The raw materials comprise the following components in parts by weight: 30 parts of prepared rhubarb; 8 parts of white mustard seed; and 2 parts of mirabilite.
The preparation method comprises the following steps:
(1) Mixing radix et rhizoma Rhei and semen Sinapis Albae, adding 10 times of water, heating to boiling state, and reflux-extracting for 1.5 hr to obtain extractive solution;
(2) Adding Mirabilitum into the extractive solution, stirring, concentrating under reduced pressure to remove water to obtain product, and drying to obtain the final product.
Comparative example 1 compared to example 1, the raw material contained no gynostemma pentaphylla.
Comparative example 2 preparation of a Chinese medicinal composition
The raw materials comprise the following components in parts by weight: 30 parts of prepared rhubarb; 15 parts of gynostemma pentaphylla; and 2 parts of mirabilite.
The preparation method comprises the following steps:
(1) Mixing radix et rhizoma Rhei and herba Gynostemmatis, adding 10 times of water, heating to boiling state, and reflux-extracting for 1.5 hr to obtain extractive solution;
(2) Adding Mirabilitum into the extractive solution, stirring, concentrating under reduced pressure to remove water to obtain product, and drying to obtain the final product.
Comparative example 2 compared to example 1, no mustard was included in the feed.
Comparative example 3 preparation of a Chinese medicinal composition
The raw materials comprise the following components in parts by weight: 30 parts of prepared rhubarb; 15 parts of gynostemma pentaphylla; 8 parts of white mustard seed; 12 parts of cassia seed; and 2 parts of mirabilite.
The preparation method comprises the following steps:
(1) Mixing radix et rhizoma Rhei, herba Gynostemmatis, semen Sinapis Albae and semen Cassiae, adding 10 times of water, heating to boiling state, and reflux-extracting for 1.5 hr to obtain extractive solution;
(2) Adding Mirabilitum into the extractive solution, stirring, concentrating under reduced pressure to remove water to obtain product, and drying to obtain the final product.
Comparative example 3 differs from example 2 in that: comparative example 3 semen Cassiae is further added to the four herbs of rhubarb horsetails, gynostemma pentaphylla, white mustard seed and Mirabilitum. While in example 2, the sedum sarmentosum is further added into the prepared rhubarb, the gynostemma pentaphylla, the white mustard seed and the Mirabilitum.
Comparative example 4 preparation of a Chinese medicinal composition
The raw materials comprise the following components in parts by weight: 30 parts of prepared rhubarb; 15 parts of gynostemma pentaphylla; 8 parts of white mustard seed; 12 parts of dried orange peel; and 2 parts of mirabilite.
The preparation method comprises the following steps:
(1) Mixing radix et rhizoma Rhei, herba Gynostemmatis, semen Sinapis Albae and pericarpium Citri Tangerinae, adding 10 times of water, heating to boiling state, and reflux-extracting for 1.5 hr to obtain extractive solution;
(2) Adding Mirabilitum into the extractive solution, stirring, concentrating under reduced pressure to remove water to obtain product, and drying to obtain the final product.
Comparative example 4 differs from example 2 in that: comparative example 4 dried orange peel was further added to the four herbs of rhubarb horsetails, gynostemma pentaphylla, white mustard seed and Mirabilitum. While in example 2, the sedum sarmentosum is further added into the prepared rhubarb, the gynostemma pentaphylla, the white mustard seed and the Mirabilitum.
Comparative example 5 preparation of a Chinese medicinal composition
The raw materials comprise the following components in parts by weight: 30 parts of prepared rhubarb; 15 parts of gynostemma pentaphylla; 8 parts of white mustard seed; 12 parts of stringy stonecrop herb; and 2 parts of mirabilite.
The preparation method comprises the following steps:
(1) Mixing radix et rhizoma Rhei, herba Gynostemmatis, semen Sinapis Albae and herba Sedi, adding 10 times of organic solvent, heating to boiling state, and reflux-extracting for 1.5 hr to obtain extractive solution;
(2) Concentrating the extractive solution under reduced pressure to remove organic solvent to obtain product, and drying the product to obtain Chinese medicinal extract;
(3) Suspending the Chinese medicinal extract with water, extracting with chloroform, and separating chloroform layer and water layer;
(4) And (3) taking the water layer, adding mirabilite, uniformly stirring, then carrying out reduced pressure concentration to remove water to obtain a product, and drying the product to obtain the traditional Chinese medicine composition.
The organic solvent in the step (1) is methanol;
the dosage ratio of the traditional Chinese medicine extract to water and chloroform in the step (3) is 1g.
Comparative example 5 is different from example 5 in that the organic solvent used in the preparation method of comparative example 5 is methanol; while example 5 used diethyl ether.
Comparative example 6 preparation of a Chinese medicinal composition
The raw materials comprise the following components in parts by weight: 30 parts of prepared rhubarb; 15 parts of gynostemma pentaphylla; 8 parts of white mustard seed; 12 parts of stringy stonecrop herb; and 2 parts of mirabilite.
The preparation method comprises the following steps:
(1) Mixing radix et rhizoma Rhei, herba Gynostemmatis, semen Sinapis Albae and herba Sedi, adding 10 times of organic solvent, heating to boiling state, and reflux-extracting for 1.5 hr to obtain extractive solution;
(2) Concentrating the extractive solution under reduced pressure to remove organic solvent to obtain product, and drying the product to obtain Chinese medicinal extract;
(3) Suspending the Chinese medicinal extract with water, extracting with chloroform, and separating chloroform layer and water layer;
(4) And (3) taking the water layer, adding mirabilite, uniformly stirring, then carrying out reduced pressure concentration to remove water to obtain a product, and drying the product to obtain the traditional Chinese medicine composition.
The organic solvent in the step (1) is ethanol with the volume fraction of 95 percent;
the dosage ratio of the traditional Chinese medicine extract to water and chloroform in the step (3) is 1g.
Comparative example 6 is different from example 5 in that the organic solvent used in the preparation method of comparative example 6 is ethanol with a volume fraction of 95%; while example 5 uses diethyl ether.
Experimental example 1
SD male rats with the body weight of 200 +/-20 g are fed with high-fat feed for 6 weeks and then are randomly divided into 11 groups, and 10 rats in each group; wherein, the experimental group 10 and the model group 1; the experimental group is administered to the sample to be tested by intragastric administration according to the dose of 100mg/kg/d every day, and the model group is administered with distilled water with the same amount as the intragastric administration; feeding high-fat feed every day, continuously performing intragastric administration for 4 weeks, collecting blood from iliac vein of each group of rats, and measuring triglyceride and total cholesterol content in serum according to the operation of kit instruction; the results are shown in Table 1.
Wherein, the experimental groups 1 to 10 respectively test the Chinese medicinal compositions prepared in examples 1, 2, 5 and 6 and comparative examples 1 to 6.
As can be seen from the experimental data in table 1, the contents of triglyceride and total cholesterol of the chinese medicinal composition prepared in example 1 tested in experimental group 1 are significantly lower than those of the model group. This indicates that: the traditional Chinese medicine composition is prepared from four traditional Chinese medicines of prepared rhubarb, gynostemma pentaphylla, white mustard seed and mirabilite, and has certain effects of reducing blood fat and preventing and treating fatty liver. Meanwhile, the contents of triglyceride and total cholesterol in the experimental group 1 are also obviously lower than those of the traditional Chinese medicine compositions prepared in the comparative examples 1 and 2 tested in the experimental groups 5 and 6. This indicates that: the composition prepared from any one of the prepared rhubarb, gynostemma pentaphylla, semen brassicae and mirabilite is not enough, and the effects of reducing blood fat and preventing and treating fatty liver are obviously reduced.
As can be seen from the experimental data in table 1, the triglyceride and total cholesterol contents of the traditional Chinese medicine composition prepared in example 2 tested in experimental group 2 are further significantly less than those of the traditional Chinese medicine composition prepared in example 1 tested in experimental group 1. This indicates that: the stringy stonecrop herb is further added into the prepared rhubarb, the gynostemma pentaphylla, the white mustard seed and the mirabilite, so that the fatty liver prevention and treatment effect of the traditional Chinese medicine composition prepared from the stringy stonecrop herb can be obviously improved.
In addition, the contents of triglyceride and total cholesterol of the chinese medicinal compositions prepared in comparative examples 3 and 4 tested in experimental groups 7 and 8 were not reduced or significantly reduced, compared to the chinese medicinal composition prepared in example 1 tested in experimental group 1. This indicates that: in the four medicinal materials of rhubarb, gynostemma pentaphylla, white mustard seed and mirabilite, the effects of reducing blood fat and preventing and treating fatty liver of the traditional Chinese medicine composition prepared from the traditional Chinese medicines can be improved or remarkably improved by not adding any traditional Chinese medicine at will. A great deal of experimental research shows that the effects of reducing blood fat and preventing and treating fatty liver of the traditional Chinese medicine composition prepared by the inventor can be further obviously improved only by adding the sedum sarmentosum in the four medicinal materials of prepared rhubarb, gynostemma pentaphylla, white mustard seed and mirabilite; the effects of reducing blood fat and preventing and treating fatty liver of the traditional Chinese medicine composition prepared by the traditional Chinese medicine composition cannot be further improved or remarkably improved by adding other traditional Chinese medicinal materials.
As can be seen from the experimental data in table 1, the triglyceride and total cholesterol contents of the traditional Chinese medicine composition prepared in example 5 tested in experimental group 3 are further significantly less than those of the traditional Chinese medicine composition prepared in example 2 tested in experimental group 2, and are also significantly less than those of the traditional Chinese medicine composition prepared in example 1 tested in experimental group 1; has excellent effects of reducing blood fat and preventing and treating fatty liver. This indicates that: the preparation method of the traditional Chinese medicine composition is also very key; the traditional Chinese medicine composition prepared by the organic solvent extraction and the extraction treatment has better fatty liver prevention and treatment effect and liver cancer resistance effect than the traditional Chinese medicine composition prepared by the water extraction.
In addition, the contents of triglyceride and total cholesterol of the chinese medicinal compositions prepared in comparative examples 5 and 5 tested in experimental groups 9 and 10 were not reduced or significantly reduced, compared to the chinese medicinal composition prepared in example 2 tested in experimental group 2. This indicates that: the prepared rhubarb, the gynostemma pentaphylla, the white mustard seed and/or the sedum sarmentosum are taken as raw materials, the selection of the organic solvent in the extraction process is very important, and the difference of the functions of reducing blood fat and preventing and treating fatty liver is huge in the traditional Chinese medicine extract prepared by adopting different organic solvents; the traditional Chinese medicine extract prepared by using ether as an organic solvent has the effects of reducing blood fat and preventing and treating fatty liver which are greatly higher than the traditional Chinese medicine composition prepared by water extraction; meanwhile, the content of the extract is greatly higher than that of the traditional Chinese medicine extract prepared by other organic solvents; compared with the traditional Chinese medicine composition prepared by water extraction, the traditional Chinese medicine extract prepared by other organic solvents cannot improve or obviously improve the effects of reducing blood fat and preventing and treating fatty liver.
As can be seen from the experimental data in table 1, the triglyceride and total cholesterol contents of the traditional Chinese medicine composition prepared in example 6 tested in experimental group 4 are further significantly less than those of the traditional Chinese medicine composition prepared in example 5 tested in experimental group 3, and are also significantly less than those of the traditional Chinese medicine compositions prepared in examples 1 and 2 tested in experimental group 1; has excellent effects of reducing blood fat and preventing and treating fatty liver. This indicates that: the dimethyl silicone oil is added into the diethyl ether, and the traditional Chinese medicine composition prepared by the organic solvent consisting of the diethyl ether and the dimethyl silicone oil has the effects of reducing blood fat and preventing and treating fatty liver which are further obviously higher than the traditional Chinese medicine composition prepared by the independent diethyl ether; meanwhile, the content of the traditional Chinese medicine composition is greatly higher than that of the traditional Chinese medicine composition prepared by water extraction.
Claims (10)
1. The traditional Chinese medicine composition is characterized by comprising the following raw material components: preparing rhubarb, gynostemma pentaphylla, white mustard seed and mirabilite.
2. The traditional Chinese medicine composition according to claim 1, which is characterized by comprising the following raw material components in parts by weight: 25-35 parts of prepared rhubarb; 10-20 parts of gynostemma pentaphylla; 5-10 parts of white mustard seed; 1-3 parts of mirabilite.
3. The traditional Chinese medicine composition according to claim 1, which is characterized by comprising the following raw material components in parts by weight: 30 parts of prepared rhubarb; 15 parts of gynostemma pentaphylla; 8 parts of white mustard seed; and 2 parts of mirabilite.
4. The Chinese medicinal composition of claim 1, wherein the composition further comprises stringy stonecrop herb.
5. The traditional Chinese medicine composition according to claim 1, wherein the weight portion of the sedum sarmentosum is 10-15;
most preferably, the weight part of the sedum sarmentosum is 12 parts.
6. The method for preparing the traditional Chinese medicine composition of any one of claims 1 to 5, which is characterized by comprising the following steps:
(1) Mixing the Chinese medicinal materials including radix et rhizoma Rhei, herba Gynostemmatis, semen Sinapis Albae and/or herba Sedi, and extracting with water to obtain extractive solution;
(2) Adding Mirabilitum into the extractive solution, stirring, concentrating under reduced pressure to remove water to obtain product, and drying to obtain the final product.
7. The preparation method according to claim 6, wherein in the step (1), the weight of the water is 5 to 15 times of the total weight of the prepared rhubarb, the gynostemma pentaphylla and the white mustard seed andor the stringy stonecrop;
most preferably, in step (1), the amount of water is 10 times the total weight of the prepared rhubarb, the gynostemma pentaphylla and the mustard seed and/or the sedum sarmentosum.
8. Use of the Chinese medicinal composition of any one of claims 1 to 5 in the preparation of a medicament having a hypolipidemic effect.
9. The use of the Chinese medicinal composition of any one of claims 1 to 5 in the preparation of a medicament for preventing and treating fatty liver.
10. The use of claim 8 or 9, wherein the medicament is in the form of a patch, paste, powder, tablet or capsule.
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Non-Patent Citations (3)
| Title |
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| 刘洋等: "脂肪肝中医临床研究进展", 医学综述, vol. 17, no. 9, pages 1372 - 1375 * |
| 董刚;薛桂蓬;: "复方白黄胶囊质量标准研究", 新疆中医药, no. 03, pages 65 - 68 * |
| 隋晓丹;邓厚波;刘铁军;: "中医药防治非酒精性脂肪肝病的研究进展", 世界华人消化杂志, no. 18, pages 1708 - 1713 * |
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