CN108210755A - A kind of phlegm wet that prevents stops up Chinese medicine preparation of Sheng type hypertension and preparation method thereof - Google Patents
A kind of phlegm wet that prevents stops up Chinese medicine preparation of Sheng type hypertension and preparation method thereof Download PDFInfo
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- CN108210755A CN108210755A CN201810174394.0A CN201810174394A CN108210755A CN 108210755 A CN108210755 A CN 108210755A CN 201810174394 A CN201810174394 A CN 201810174394A CN 108210755 A CN108210755 A CN 108210755A
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Classifications
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/888—Araceae (Arum family), e.g. caladium, calla lily or skunk cabbage
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/06—Fungi, e.g. yeasts
- A61K36/07—Basidiomycota, e.g. Cryptococcus
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
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- A61K36/185—Magnoliopsida (dicotyledons)
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
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- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K2236/30—Extraction of the material
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- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/55—Liquid-liquid separation; Phase separation
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- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
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- Epidemiology (AREA)
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- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Alternative & Traditional Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Gastroenterology & Hepatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The present invention provides a kind of Chinese medicine preparation and preparation method prevented phlegm wet and stop up Sheng type hypertension, which is made of the active principle compatibility of banxia baizhu tianma decoction：0~25.9 part of total starches, 0~18 part of total saposins, 0~14.5 part of total polyphenols；The preparation method of said preparation is provided simultaneously, under the premise of ensureing that medicinal active ingredient fully extracts, establish the high efficiency extraction for being suitable for producing greatly, process for purification, total polyphenols, total saposins and the total starches component of the refined 6 taste Chinese medicines of the full side of banxia baizhu tianma decoction of purifying, have developed and stop up Sheng type high blood pressure disease Innovative TCMs with the relatively clear phlegm wet of independent intellectual property right, effective substance and the mechanism of action.
Description
Technical field
The invention belongs to traditional Chinese medicine research development fields, and in particular to a kind of Chinese medicine preparation prevented phlegm wet and stop up Sheng type hypertension
And preparation method thereof.
Background technology
Hypertension refers to increase as main feature with systemic arterial blood pressure, can be with heart, blood vessel, brain or kidney etc.
Multiple organ functionals or the systemic disease of organic change are that multiple-factor inheritance factor is generated with environmental factor reciprocation
A kind of disease.According to《New Chinese medicine treats the guideline of clinical investigations of high blood pressure》（Ministry of Public Health's version in 1993）Hypertension
High blood pressure is divided into overabundant liver-fire, hyperactivity of yang due to yin deficiency, yin-yang deficiency and phlegm wet and stops up 4 types of containing by sick medicine typing standard,《Chinese medicine is new
Medicine guideline of clinical investigations》（National Drug Administration's version in 2002）High blood pressure is equally divided into overabundant liver-fire, the moon
Empty sun is high, yin-yang deficiency and phlegm wet stops up 4 types of containing.Modern research suggests that " phlegm wet " of dyslipidemia and the traditional Chinese medical science is closely related, TC,
The raising of TG, LDL content is " phlegm wet " distinctive important biochemical indicator and material base.In modern society, due to population old-age group
To change, the factors such as rhythm of life is fast, overnutrition, stress are big, phlegm wet, which stops up Sheng type hypertension, has become common clinical disease,
TCM Syndrome Differentiation of Hypertension forms maximum in distribution proportion, seriously affects daily life.
" traditional Chinese medical science passes the medicine not amount of biography " and the thought of " the secret amount of being that the traditional Chinese medical science does not pass " can understand in terms of 2.First, the traditional Chinese medical science
The ratio of prescription composition Traditional Chinese Medicine dosage；Second, quantity relative ratio relationship between the ingredient and component of tcm prescription entirety.Tcm components by
Zhang Baili academician proposes, is under herbal medicine efficacy component theoretical direction, on the basis of traditional classical prescription, proved recipe, with component compatibility mould
The modern tcm components of formula research and development are that Innovative TCMs study comparatively ideal pattern.Component structure theory is the further hair of tcm components
Exhibition, it is indicated that the material base of Chinese medicine is an orderly entirety, and component is to form the basic unit of the material base, component and group
/ there are a kind of relationship of amount, here it is so-called structures.Component structure Chinese medicine be inherit traditional Chinese medicine globality and
On the basis of systematic and under the guidance of " component structure " theory, not only quantity relative ratio relationship between clear and definite component, but also clearly disclose its drug effect
The new medicine composition of mechanism of action is conducive to illustrate the essence of Chinese medicine Effective Compounds and effect, can embody multicomponent,
Multiple target point and the advantage of integration improve preparation Quality Control level and clinical efficacy, Chinese medicine are promoted to move towards domestic and international market.
Banxia baizhu tianma decoction is derived from into book Yongzheng Yu 10 years（1732）Comprehensive medical book《Medicine Comprehended》（Clearly
Cheng Guopeng writes）, it is made of the tuber of pinellia, Rhizoma Gastrodiae, Poria cocos, Exocarpium Citri Rubrum, Rhizoma Atractylodis Macrocephalae, Radix Glycyrrhizae.With eliminating dampness and eliminating phlegm, the effect of suppressing hyperactive liver for calming endogenous wind.It is main
It controls and the cards such as caused dizziness and headache, chest tightness and emesis, white and greasy fur, wiry and rolling pulse is disturbed in wind phlegm, be that tcm clinical practice treatment phlegm wet stops up Sheng type
The representative prescription of hypertension, it is curative for effect.Although it is clinically had been used at present with the related preparations of Rhizoma Gastrodiae or Gastrodin prescription
The treatment of high blood pressure disease.But there are compatibility unreasonable structure, preparation process backwardness, clinical efficacy be not true mostly for these preparations
It cuts, the problems such as safety in utilization is not high, existing kind can also meet far away market needs, particularly have no with the classic prescriptions tuber of pinellia
Baizhu Tianma soup is the listing formulation application of basic prescription in clinic.
Invention content
The problem of for above-mentioned preparation, the present invention provides a kind of Chinese medicine systems for preventing phlegm wet and stopping up Sheng type hypertension
Agent and preparation method, the Chinese medicine preparation is by the banxia baizhu tianma decoction square tuber of pinellia, Rhizoma Gastrodiae, Poria cocos, Exocarpium Citri Rubrum, Rhizoma Atractylodis Macrocephalae, 6 taste group of Radix Glycyrrhizae entirely
Into 3 part active principle compatibility composition of the total polyphenols of Chinese medicine, total saposins and total starches, there is synergistic function.
A kind of Chinese medicine preparation prevented phlegm wet and stop up Sheng type hypertension, is matched by the following weight of banxia baizhu tianma decoction extraction
Traditional Chinese medicine effective ingredient be made：0~25.9 part of total starches；0~18 part of total saposins；0~14.5 part of total polyphenols.
Preferably, above-mentioned Chinese medicine preparation, the traditional Chinese medicine effective ingredient matched by the following weight of banxia baizhu tianma decoction extraction
It is made：12.95 parts of total polyphenols；9 parts of total saposins；14.5 parts of total starches.
A kind of preparation method for preventing phlegm wet and stopping up the Chinese medicine preparation of Sheng type hypertension, is made by following steps：
（1）Banxia baizhu tianma decoction extracts medicinal extract：The prescription Chinese medicine tuber of pinellia, Rhizoma Atractylodis Macrocephalae, Rhizoma Gastrodiae, Poria cocos, Exocarpium Citri Rubrum, Radix Glycyrrhizae are distinguished first
It crushes, weighs the coarse powder between 10~20 mesh in proportion, extract 3 times respectively, amount of water is followed successively by 10 times, 8 times, 8 times, during extraction
Between be followed successively by 120min, 90min, 90min, extracting solution coarse filtration successively, 3500rmin-125 min are centrifuged, are filtered, are merged, it is dense
Contracting, obtains medicinal extract；
（2）Extract total starches：Take step（1）In medicinal extract with polycaprolactam, medicinal extract is 1: 3 with polyamide ratio, is added on DM301
At the top of type macroporous absorbent resin, medicinal extract is 1: 3 with resin ratio, is eluted with water, and elution amount is 10 times of column volumes, elution volume flow
It controls as 0.5mLmin-1, eluent is collected, is concentrated under reduced pressure, total starches are obtained after dry；
（3）Extract total saposins：Take step（2）In " polyamide+DM301 types macroporous absorbent resin " column, with 50% ethanol elution,
Elution amount is 10 times of column volumes, and elution volume flow control is 0.5mLmin-1, eluent is collected, is concentrated under reduced pressure, is obtained after dry
Total saposins；
（4）Extract total polyphenols：Take step（3）In " polyamide+DM301 types macroporous absorbent resin " column, with 80% ethanol elution,
Elution amount is 10 times of column volumes, and elution volume flow control is 0.5mLmin-1, eluent is collected, is concentrated under reduced pressure, is obtained after dry
Total polyphenols；
（5）By step（2）-（4）Preparation is made according to specified number in the active principle of extraction.
The Chinese medicine preparation that the prevention phlegm wet stops up Sheng type high blood pressure disease is tablet, capsule, granule, oral liquid,
Syrup, pill, sustained-release tablet or pellet.
Confirmatory experiment
Using 4 factor, 4 horizontal quadrature design method, Sheng type Hypertensive Rats pharmacology model, serum total cholesterol are stopped up with phlegm wet
（TC）, triacylglycerol（TG）, high-density lipoprotein（HDL）, low-density lipoprotein（LDL）, blood glucose（Glu）, Fasting insulin
（FINS）, nitric oxide（NO）, serum angiotensinⅡ（ANG-Ⅱ）And Endothelin（ET）Multiple medicine imitates index comprehensive evaluation, really
Determine the best compatibility proportioning of total starches, total saposins and total polyphenols.
Experiment stops up Sheng type hypertensive rat model with phlegm wet, is randomly divided into 8 groups（n=8）It is tested, experiment packet is：It is empty
White control group, the high, medium and low dosage group of banxia baizhu tianma decoction（High dose group 8gkg-1, middle dose group 4gkg-1, low dosage
Group 0.8gkg-1, respective handling group（Optimum proportion scheme removes one of active principle successively）And component compound group.By with
Upper method feeds 4W.TC, TG, HDL, LDL, Glu, FINS, NO, ANG- II and ET is surveyed after experiment, experimental result is averaged.
1 component compound confirmatory experiment result of table（, n=8）
Note:R=, it is blank group rat CHO, TG, LDL, GL Μ, FINS, Ang II, ET
Average value is the average value of each group rat CHO, TG, HDL, LDL, GL Μ, FINS, NO, Ang II, ET, is blank group rat
The average value of HDL, NO are the average value of each group rat HDL, NO.
As shown in Table 1, the drug effect of component compound formed according to the optimum proportioning that orthogonal design filters out integrates efficient
（E）More than each dosage group in banxia baizhu tianma decoction original side, dosage is obviously reduced, and illustrates that compound reaches phase using component compound
With dosage can be greatly reduced during drug effect.When in banxia baizhu tianma decoction component compound, remove 3 constituent parts wherein it
One, confrontation phlegm wet stops up the effective percentage of Sheng type Hypertensive Rats（E）It is obviously reduced.
Advantageous effect：
1st, active principle Extraction and enrichment purifying process：
Under the premise of ensureing that medicinal active ingredient fully extracts, the high efficiency extraction for being suitable for producing greatly, process for purification are established,
Total polyphenols, total saposins and the total starches component of the refined 6 taste Chinese medicines of the full side of banxia baizhu tianma decoction of purifying.Rhizoma Gastrodiae, Poria cocos, tangerine in side
Contain a large amount of polyphenol in red and Radix Glycyrrhizae（Including phenolic acid and flavones）Chemical composition is main pharmacodynamics substance, especially monarch drug in a prescription Rhizoma Gastrodiae
In main chemical compositions Gastrodin etc., decompression drug efficacy study is more thorough, therefore active principle preparation process is with enriching and purifying
Polyphenols chemical composition is primary and foremost purpose in side, secondly saponins chemical composition, is the macromolecular chemistries ingredient such as polysaccharide again.
The polyamide of use can form hydrogen bond with the compound rich in phenolic hydroxyl group and adsorb, and be the resin of excellent enrichment polyphenols
Material.But polyamide also has " dual chromatography " effect other than " Hydrogen Binding Adsorption ", when with polar solvent（Such as aqueous solvent）Make
During for mobile phase, as non-polar stationary phase, chromatographic behavior is similar to reversed phase partition chromatography, leads to phenol the alkyl in polyamide
Glycosides is first eluted than aglycon；DM301 type macroporous absorbent resins are polar copolymers in styrene type, suitable for having low pole and pole
Property organic compound separation, purifying, the Polyphenols chemical composition that the two combination can be preferably in enriching and purifying side.
2nd, active principle compatibility optimizes：
For comprehensive, the comprehensive action character for reflecting the more effects of banxia baizhu tianma decoction multicomponent, with serum total cholesterol
（TC）, triacylglycerol（TG）, high-density lipoprotein（HDL）, low-density lipoprotein（LDL）, blood glucose（Glu）, Fasting insulin
（FINS）, nitric oxide（NO）, serum angiotensinⅡ（ANG-Ⅱ）And Endothelin（ET）Etc. multiple evaluating drug effect indexs, then
Weight coefficient is assigned according to the importance of different drug effects, calculates the drug effect that comprehensive effective percentage carrys out choosing comprehensively component compound；Using
Orthogonal design be design method that new drug development craft screening mainly uses.It is numerous compared to some factor levels, relationship is complicated
And the mathematic(al) structure expression of inner link is reduced to the mathematical model of cinder box, can more embody the contiguity principle of systematology,
That is more bodies such as Synergy and attenuation " non-additive property " compatibility relationship is not only saved human and material resources and test period, but also can be analyzed wherein
It interacts between active principle, function ingredients, useless component and component（Collaboration or antagonism）And the best compatibility of component compound
Dosage.
3rd, preparation process：
Modern Pharmacodynamics screening is combined according to traditional Chinese medicine compatibility theory, component structure theory, with " group effect relationship, component compatibility,
Optimization design " and Modern preparations technology, are studied in detail each link, compared with prior art, have base
Plinth research work is sturdy, and active principle effective substance understands, extraction and separation technology is ripe, new technology and new process application journey
The features such as high is spent, developing, there is the relatively clear phlegm wet of independent intellectual property right, effective substance and the mechanism of action to stop up Sheng type hypertension
Disease Innovative TCMs, fill a hole in the market, and are of great immediate significance and application value.
Specific embodiment
By embodiment the present invention is further explained the active principle compatibility Chinese medicine and its formulation preparation method, but this
Invention is not limited to the content that the following example includes.
Embodiment 1
A kind of Chinese medicine preparation prevented phlegm wet and stop up Sheng type hypertension, is matched by the following weight that banxia baizhu tianma decoction extracts
Traditional Chinese medicine effective ingredient is made：18 parts of total saposins；14.5 parts of total polyphenols.
A kind of preparation method for preventing phlegm wet and stopping up the Chinese medicine preparation of Sheng type hypertension, is made by following steps：
（1）Banxia baizhu tianma decoction extracts medicinal extract：By the prescription Chinese medicine tuber of pinellia, Rhizoma Atractylodis Macrocephalae, Rhizoma Gastrodiae, Poria cocos, Exocarpium Citri Rubrum, Radix Glycyrrhizae difference powder
It is broken, the coarse powder between 10~20 mesh is weighed in proportion, is extracted 3 times respectively, amount of water is followed successively by 10 times, 8 times, 8 times, extraction time
It is followed successively by 120min, 90min, 90min, extracting solution coarse filtration successively, centrifugation（3500r·min-1, 25 min）, it filters, merges, it is dense
Contracting, obtains medicinal extract；
（2）Extract total starches：Take step（1）In medicinal extract with polycaprolactam, medicinal extract is 1: 3 with polyamide ratio, is added on DM301
At the top of type macroporous absorbent resin, medicinal extract is 1: 3 with resin ratio, is eluted with water, and elution amount is 10 times of column volumes, elution volume flow
It controls as 0.5mLmin-1, eluent is collected, is concentrated under reduced pressure, total starches are obtained after dry；
（3）Extract total saposins：Take step（2）In " polyamide+DM301 types macroporous absorbent resin " column, with 50% ethanol elution,
Elution amount is 10 times of column volumes, and elution volume flow control is 0.5mLmin-1, eluent is collected, is concentrated under reduced pressure, is obtained after dry
Total saposins；
（4）Extract total polyphenols：Take step（3）In " polyamide+DM301 types macroporous absorbent resin " column, with 80% ethanol elution,
Elution amount is 10 times of column volumes, and elution volume flow control is 0.5mLmin-1, eluent is collected, is concentrated under reduced pressure, is obtained after dry
Total polyphenols；
（5）By step（2）-（4）Preparation is made according to specified number in the active principle of extraction.
Embodiment 2
A kind of Chinese medicine preparation prevented phlegm wet and stop up Sheng type hypertension, is matched by the following weight that banxia baizhu tianma decoction extracts
Traditional Chinese medicine effective ingredient is made：25.9 parts of total starches；14.5 parts of total polyphenols.
The preparation method of the Chinese medicine preparation, with embodiment 1.
Embodiment 3
A kind of Chinese medicine preparation prevented phlegm wet and stop up Sheng type hypertension, is matched by the following weight that banxia baizhu tianma decoction extracts
Traditional Chinese medicine effective ingredient is made：25.9 parts of total starches；18 parts of total saposins.
The preparation method of the Chinese medicine preparation, with embodiment 1.
Embodiment 4
A kind of Chinese medicine preparation prevented phlegm wet and stop up Sheng type hypertension, by the following weight proportioning of banxia baizhu tianma decoction extraction
Medicine active principle is made：12.95 parts of total polyphenols；9 parts of total saposins；14.5 parts of total starches.
A kind of preparation method for preventing phlegm wet and stopping up the Chinese medicine preparation of Sheng type hypertension, is made by following steps：
（1）Banxia baizhu tianma decoction extracts medicinal extract：By the prescription Chinese medicine tuber of pinellia, Rhizoma Atractylodis Macrocephalae, Rhizoma Gastrodiae, Poria cocos, Exocarpium Citri Rubrum, Radix Glycyrrhizae difference powder
It is broken, the coarse powder between 10~20 mesh is weighed in proportion, is extracted 3 times respectively, amount of water is followed successively by 10 times, 8 times, 8 times, extraction time
It is followed successively by 120min, 90min, 90min, extracting solution coarse filtration successively, centrifugation（3500r·min-1, 25 min）, it filters, merges, it is dense
Contracting, obtains medicinal extract；
（2）Extract total starches：Take step（1）In medicinal extract with polycaprolactam, medicinal extract is 1: 3 with polyamide ratio, is added on DM301
At the top of type macroporous absorbent resin, medicinal extract is 1: 3 with resin ratio, is eluted with water, and elution amount is 10 times of column volumes, elution volume flow
It controls as 0.5mLmin-1, eluent is collected, is concentrated under reduced pressure, total starches are obtained after dry；
（3）Extract total saposins：Take step（2）In " polyamide+DM301 types macroporous absorbent resin " column, with 50% ethanol elution,
Elution amount is 10 times of column volumes, and elution volume flow control is 0.5mLmin-1, eluent is collected, is concentrated under reduced pressure, is obtained after dry
Total saposins；
（4）Extract total polyphenols：Take step（3）In " polyamide+DM301 types macroporous absorbent resin " column, with 80% ethanol elution,
Elution amount is 10 times of column volumes, and elution volume flow control is 0.5mLmin-1, eluent is collected, is concentrated under reduced pressure, is obtained after dry
Total polyphenols；
（5）The preparation of capsule：Total starches 242g, total saposins 180g, total polyphenols 161.9g are taken, crushes, adds appropriate amount of starch, mixing,
It is encapsulated, be made 1000 to get.
The preparation of syrup：Total starches 242g, total saposins 180g, total polyphenols 161.9g are taken, suitable quantity of water is added to make dissolving, is stirred,
Stand, filtration, add sucrose 200g, sodium benzoate 3g, add water 1000ml, stir evenly, it is filling, sterilize to get.
Step（2）Described in active principle total starches content（With glucose meter）Up to 80%；Step（3）Described in
The content of active principle total saposins（In terms of glycyrrhizin）Up to 68%；Step（4）Described in active principle total polyphenols content
（In terms of Gastrodin）Up to 89%.
Claims (4)
1. a kind of Chinese medicine preparation prevented phlegm wet and stop up Sheng type hypertension, which is characterized in that under being extracted by banxia baizhu tianma decoction
The traditional Chinese medicine effective ingredient for stating weight proportion is made：0~25.9 part of total starches；0~18 part of total saposins；0~14.5 part of total polyphenols.
2. Chinese medicine preparation according to claim 1, which is characterized in that the following weight extracted by banxia baizhu tianma decoction is matched
The traditional Chinese medicine effective ingredient of ratio is made：12.95 parts of total polyphenols；9 parts of total saposins；14.5 parts of total starches.
3. a kind of preparation method of Chinese medicine preparation described in claim 1, which is characterized in that be made by following steps：
（1）Banxia baizhu tianma decoction extracts medicinal extract：The prescription Chinese medicine tuber of pinellia, Rhizoma Atractylodis Macrocephalae, Rhizoma Gastrodiae, Poria cocos, Exocarpium Citri Rubrum, Radix Glycyrrhizae are distinguished first
It crushes, weighs the coarse powder between 10~20 mesh in proportion, extract 3 times respectively, amount of water is followed successively by 10 times, 8 times, 8 times, during extraction
Between be followed successively by 120min, 90min, 90min, extracting solution coarse filtration successively, 3500rmin-125 min are centrifuged, are filtered, are merged, it is dense
Contracting, obtains medicinal extract；
（2）Extract total starches：Take step（1）In medicinal extract with polycaprolactam, medicinal extract is 1: 3 with polyamide ratio, is added on DM301
At the top of type macroporous absorbent resin, medicinal extract is 1: 3 with resin ratio, is eluted with water, and elution amount is 10 times of column volumes, elution volume flow
It controls as 0.5mLmin-1, eluent is collected, is concentrated under reduced pressure, total starches are obtained after dry；
（3）Extract total saposins：Take step（2）In " polyamide+DM301 types macroporous absorbent resin " column, with 50% ethanol elution,
Elution amount is 10 times of column volumes, and elution volume flow control is 0.5mLmin-1, eluent is collected, is concentrated under reduced pressure, is obtained after dry
Total saposins；
（4）Extract total polyphenols：Take step（3）In " polyamide+DM301 types macroporous absorbent resin " column, with 80% ethanol elution,
Elution amount is 10 times of column volumes, and elution volume flow control is 0.5mLmin-1, eluent is collected, is concentrated under reduced pressure, is obtained after dry
Total polyphenols；
（5）By step（2）-（4）Preparation is made according to specified number in the active principle of extraction.
4. Chinese medicine preparation according to claim 1, which is characterized in that the preparation can be tablet, capsule, particle
Agent, oral liquid, syrup, pill, sustained-release tablet or pellet.
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Effective date of registration: 20240509 Address after: No. 2 Huayu 10th Street, Wuyi Country Garden, Pengjiang District, Jiangmen City, Guangdong Province, 529000 Patentee after: Qiu Yanmei Country or region after: China Address before: 250014, swallow Road, Lixia District, Ji'nan, Shandong, 7, Shanxi Patentee before: SHANDONG ACADEMY OF CHINESE MEDICINE Country or region before: China |