CN115960251A - Baff-r靶向嵌合抗原受体修饰的t细胞及其用途 - Google Patents

Baff-r靶向嵌合抗原受体修饰的t细胞及其用途 Download PDF

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CN115960251A
CN115960251A CN202210970028.2A CN202210970028A CN115960251A CN 115960251 A CN115960251 A CN 115960251A CN 202210970028 A CN202210970028 A CN 202210970028A CN 115960251 A CN115960251 A CN 115960251A
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cells
baff
chain variable
optionally
variable region
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秦宏
拉里·W·夸克
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University of Texas System
City of Hope
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University of Texas System
City of Hope
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CN202210970028.2A 2016-06-06 2017-06-06 Baff-r靶向嵌合抗原受体修饰的t细胞及其用途 Pending CN115960251A (zh)

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US201662346324P 2016-06-06 2016-06-06
US62/346,324 2016-06-06
US201662396767P 2016-09-19 2016-09-19
US62/396,767 2016-09-19
CN201780035645.0A CN109311991B (zh) 2016-06-06 2017-06-06 Baff-r靶向嵌合抗原受体修饰的t细胞及其用途
PCT/US2017/036178 WO2017214167A1 (en) 2016-06-06 2017-06-06 Baff-r targeted chimeric antigen receptor-modified t-cells and uses thereof

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CN201780035645.0A Active CN109311991B (zh) 2016-06-06 2017-06-06 Baff-r靶向嵌合抗原受体修饰的t细胞及其用途

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ES2949648T3 (es) 2012-12-20 2023-10-02 Purdue Research Foundation Células T que expresan un receptor antigénico quimérico como terapia contra el cáncer
JP7282521B2 (ja) 2016-04-08 2023-05-29 パーデュー・リサーチ・ファウンデイション Car t細胞療法のための方法および組成物
AU2017277269C1 (en) * 2016-06-06 2024-10-31 Board Of Regents, The University Of Texas System BAFF-R targeted chimeric antigen receptor-modified T-cells and uses thereof
US11850262B2 (en) 2017-02-28 2023-12-26 Purdue Research Foundation Compositions and methods for CAR T cell therapy
BR112020014913A2 (pt) 2018-01-22 2020-12-08 Seattle Children's Hospital (dba Seattle Children's Research Institute) Métodos para uso de células t car
CA3091674A1 (en) 2018-02-23 2019-08-29 Endocyte, Inc. Sequencing method for car t cell therapy
US20200199232A1 (en) * 2018-12-19 2020-06-25 City Of Hope Baff-r bispecific t-cell engager antibody
KR20210129125A (ko) * 2019-02-20 2021-10-27 시티 오브 호프 Baff-r/cd19 표적화된 키메라 항원 수용체-변형된 t 세포 및 그의 용도
US12023354B2 (en) 2019-05-31 2024-07-02 Case Western Reserve University Targeting B cell activating factor receptor (BAFF-R) using ligand-based chimeric antigen receptor (CAR)-T cells
WO2021064718A1 (en) * 2019-10-01 2021-04-08 Case Western Reserve University Targeting b cell activating factor receptor (baff-r) using ligand-based chimeric antigen receptor (car)-t cells
WO2021163989A1 (en) * 2020-02-21 2021-08-26 Yinnuolai Biotech Ltd. Anti-baff receptor antibodies and uses thereof
CN111499723B (zh) * 2020-05-28 2021-04-09 广州百暨基因科技有限公司 一种嵌合抗原受体及其应用
JP2024519943A (ja) * 2021-05-19 2024-05-21 上海詩健生物科技有限公司 Baff-rを特異的に認識するキメラ抗原受容体分子及びその使用
JP2024528038A (ja) 2021-07-29 2024-07-26 ソノマ バイオセラピューティクス, インコーポレイテッド 調節性t細胞を標的として自己免疫疾患を処置するための滑膜細胞外マトリックス特異的キメラ抗原受容体
AU2023281726A1 (en) * 2022-06-01 2025-01-09 Seattle Children's Hospital D/B/A Seattle Children's Research Institute Recombinant receptors binding b cell activation factor receptor and uses thereof
CN116143943B (zh) * 2022-10-31 2023-09-01 邦恩泰(山东)生物医药科技集团股份有限公司 一种靶向baffr嵌合抗原受体、car-t细胞及应用
WO2025006795A1 (en) * 2023-06-30 2025-01-02 Board Of Regents, The University Of Texas System Tsyn-seq: a t cell synapse-based tumor antigen identification platform
CN117050195B (zh) * 2023-10-13 2023-12-19 旭和(天津)医药科技有限公司 一种靶向baffr嵌合抗原受体、car-t细胞和应用

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4946778A (en) 1987-09-21 1990-08-07 Genex Corporation Single polypeptide chain binding molecules
US5530101A (en) 1988-12-28 1996-06-25 Protein Design Labs, Inc. Humanized immunoglobulins
EP1690935A3 (en) 1990-01-12 2008-07-30 Abgenix, Inc. Generation of xenogeneic antibodies
US5427908A (en) 1990-05-01 1995-06-27 Affymax Technologies N.V. Recombinant library screening methods
ES2139598T3 (es) 1990-07-10 2000-02-16 Medical Res Council Procedimientos para la produccion de miembros de parejas de union especifica.
GB9015198D0 (en) 1990-07-10 1990-08-29 Brien Caroline J O Binding substance
WO1993012227A1 (en) 1991-12-17 1993-06-24 Genpharm International, Inc. Transgenic non-human animals capable of producing heterologous antibodies
US5639641A (en) 1992-09-09 1997-06-17 Immunogen Inc. Resurfacing of rodent antibodies
US6066718A (en) 1992-09-25 2000-05-23 Novartis Corporation Reshaped monoclonal antibodies against an immunoglobulin isotype
JP2005538706A (ja) 2001-07-12 2005-12-22 ジェファーソン フーテ, スーパーヒト化抗体
US20080181888A1 (en) 2004-12-31 2008-07-31 Ambrose Christine M Polypeptides That Bind Br3 and Uses Thereof
CN106459924A (zh) 2014-04-23 2017-02-22 得克萨斯州大学系统董事会 用于疗法中的嵌合抗原受体(car)及其制备方法
GB201412658D0 (en) 2014-07-16 2014-08-27 Ucb Biopharma Sprl Molecules
KR20160016725A (ko) * 2014-08-05 2016-02-15 주식회사 유영제약 암 세포에 과발현되는 IL13Rα2에 특이적으로 결합하는 키메라 항원 수용체로 변형된 T 세포
AU2017277269C1 (en) 2016-06-06 2024-10-31 Board Of Regents, The University Of Texas System BAFF-R targeted chimeric antigen receptor-modified T-cells and uses thereof

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