CN115918770A - Preparation method of marine organism health-preserving health-care peptide preparation - Google Patents
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Abstract
The invention discloses a preparation method of a marine organism health-preserving health-care peptide preparation, which relates to the technical field of health-care peptide preparation and comprises the following steps: step one, processing raw materials, namely processing sea cucumber raw materials to prepare the sea cucumber raw materials into powder; step two, processing auxiliary materials, namely preheating the auxiliary materials to be added and mixing the auxiliary materials with the sea cucumber powder obtained in the step one; step three, finished product inspection is finished, the mixed preparation is inspected, and defective products are removed; step four, the preparation is stored. According to the invention, the sea cucumber raw material is crushed in a low-temperature shearing mode, so that the biological activity is preserved, the peptide content of the preparation is increased, the lactobacillus is added into the sea cucumber powder after biological enzymolysis, and through the metabolism of microorganisms, micromolecular fishy substances participate in anabolism and are converted into macromolecular substances without fishy smell to realize fishy smell removal, so that the preparation can be accepted by the public, and the preparation has the advantage of convenience in fishy smell removal.
Description
Technical Field
The invention relates to the technical field of preparation of health-care peptide preparations, in particular to a preparation method of a marine organism health-care peptide preparation.
Background
The health food is a food which is claimed to have a specific health function or aim at supplementing vitamins and minerals, is suitable for specific people to eat, has the function of regulating the organism, does not aim at treating diseases, and does not generate any acute, subacute or chronic harm to human bodies, and in recent years, the science believes that protein absorbed by human bodies is mainly absorbed in the form of peptide, the peptide is a molecule consisting of amino acid, the molecular weight is 5000-200 Da, and the health food has extremely strong activity and diversity, can regulate the physiological functions of various systems and cells in human bodies by using the physiological functions and biological activities of peptide nutrition, and activates related enzyme elements in the human bodies, so that various peptides become important substances for human body health, and the sea cucumber is rich in more than 50 nutrients such as polyamino glucose, polypeptide, collagen, nucleic acid, sea cucumber saponin, chondroitin sulfate, various vitamins, various amino acids, carbohydrate and the like, therefore, the health peptide preparation on the market often utilizes the sea cucumber as a preparation raw material. The following problems exist in the prior art:
in the preparation process of the existing marine organism health-preserving health-care peptide preparation, the sea cucumber is used as a raw material, and the oyster powder and other auxiliary materials are added, so that the prepared preparation is heavy in fishy smell and is not easy to accept by users.
Disclosure of Invention
The invention provides a preparation method of a marine organism health-preserving health-care peptide preparation, which aims to solve the problems in the background technology.
In order to solve the technical problems, the technical scheme adopted by the invention is as follows:
a preparation method of a marine organism health-preserving health-care peptide preparation comprises the following steps: step one, processing a raw material, namely processing a sea cucumber raw material to prepare the sea cucumber raw material into powder; step two, processing auxiliary materials, namely preheating the auxiliary materials to be added and mixing the auxiliary materials with the sea cucumber powder obtained in the step one; step three, finished product inspection is finished, the mixed preparation is inspected, and defective products are removed; and step four, storing the preparation, namely storing the preparation after the detection.
The technical scheme of the invention is further improved as follows: in the first step, 200-300 g of sea cucumber raw material is taken and placed in a grinder to be ground for 20-3 min, and meanwhile, an air cooler is used for maintaining the temperature of the sea cucumber raw material in the grinder at 3-5 ℃, so that the sea cucumber raw material is subjected to low-temperature shearing.
By adopting the technical scheme, the air cooler is utilized to maintain the low-temperature state of the sea cucumber powder, the heat generated in the crushing process can be prevented from damaging the structure of biological protein, and biological active ingredients in the sea cucumber raw material are reserved to the greatest extent.
The technical scheme of the invention is further improved as follows: in the first step, 100-500 g of protease is added into the sea cucumber powder which is cut at low temperature, the protease and the sea cucumber powder generate biochemical metabolic reaction, macromolecular protein in the sea cucumber powder is converted into micromolecular protein active peptide, various amino acid sequencing and bioactive peptides with different molecular mass sizes are produced under the metabolism and fermentation conditions of microorganisms, and the biological enzymolysis is carried out on the sea cucumber powder.
According to the technical scheme, the protease and the sea cucumber powder are subjected to biochemical metabolic reaction, macromolecular proteins in the sea cucumber powder are converted into micromolecular protein active peptides, various bioactive peptides with different amino acid sequences and molecular mass sizes are produced under the metabolism and fermentation conditions of microorganisms, and the peptide content of the preparation is increased.
The technical scheme of the invention is further improved as follows: in the first step, 70-200 g of lactic acid bacteria are added into the sea cucumber powder after biological enzymolysis, and through the metabolism of microorganisms, micromolecular fishy substances participate in anabolism and are converted into non-fishy macromolecular substances to realize fishy smell removal, so that the fishy smell of the sea cucumber powder is removed through fermentation.
According to the technical scheme, lactic acid bacteria are added into the sea cucumber powder after biological enzymolysis, and the fishy smell in the sea cucumber powder is removed through the metabolism of microorganisms.
The technical scheme of the invention is further improved as follows: preparing 700-800 g of oyster powder in the second step, then placing the oyster powder and the sea cucumber powder into a stirrer to be stirred for 10-20 min, after stirring is completed, adding 50-70 g of 95% ethanol into the mixture, then heating in a water bath at 80-95 ℃ for 30-45 min, after the water bath is completed, taking out the mixture, and pressing the mixture into tablets by using a press molding machine.
The technical scheme of the invention is further improved as follows: and in the third step, randomly sampling the compression-molded tablets every 30-40 s, observing whether the appearance of the sample is damaged or not, and detecting the weight of the sample by using a balance.
By adopting the technical scheme, the probability of defective products of the preparation can be reduced through sampling detection in the scheme.
The technical scheme of the invention is further improved as follows: and in the fourth step, the checked tablets are placed into a PVC plate for packaging, then a vacuumizing machine is used for vacuumizing the air in the PVC plate, the PVC is packed into boxes for storage after vacuum vacuumizing is completed, and then the medicine boxes are placed into a low-temperature dry refrigeration house, wherein the temperature of the refrigeration house is maintained at 4-6 ℃.
By adopting the technical scheme, the preparation is packed into the box and stored in the refrigeration house, so that the biological activity in the preparation can be reduced, and the storage time of the preparation can be prolonged.
Due to the adoption of the technical scheme, compared with the prior art, the invention has the technical progress that:
1. the invention provides a preparation method of a marine organism health-preserving health-care peptide preparation, which comprises the steps of placing a sea cucumber raw material into a pulverizer for pulverizing under the mutual cooperation of the steps of raw material treatment, low-temperature shearing, biological enzymolysis and the like, simultaneously maintaining the temperature of the sea cucumber raw material in the pulverizer at a low temperature state by using an air cooler, retaining the biological active ingredients in the sea cucumber raw material to the maximum extent, adding protease, carrying out biochemical metabolic reaction on the protease and the sea cucumber powder, converting macromolecular protein in the sea cucumber powder into small-molecular protein active peptide, producing various biological active peptides with different amino acid sequences and molecular mass sizes under the metabolism and fermentation conditions of microorganisms, increasing the peptide content of the preparation, and having the advantages of conveniently preserving the biological activity and increasing the peptide content of the preparation.
2. The invention provides a preparation method of a marine organism health-preserving health-care peptide preparation, which comprises the steps of removing fishy smell through fermentation, processing auxiliary materials, stirring and mixing, heating in a water bath, molding by pressing and the like, adding lactic acid bacteria into sea cucumber powder which is subjected to biological enzymolysis, converting micromolecule fishy smell substances into macromolecular substances without fishy smell through the metabolism of microorganisms in a synthetic metabolism manner to realize fishy smell removal, then putting oyster powder and the sea cucumber powder into a stirrer for mixing, adding ethanol into the mixture, heating in the water bath, taking out the mixture after the water bath is finished, and pressing the mixture into tablets by using a molding press, so that the preparation can be more accepted by the public and has the advantage of conveniently removing the fishy smell.
3. The invention provides a preparation method of a marine organism health-preserving health-care peptide preparation, which comprises the steps of finished product inspection, random sampling, appearance detection, weight detection, preparation storage, package sealing, hollow pumping, finished product storage and the like, wherein the steps of finished product inspection, random sampling is carried out on compression-molded tablets, whether the appearance of a sample is damaged or not is observed, the weight of the sample is detected by using a balance, the probability of defective products of the preparation is reduced, the inspected tablets are placed into a PVC plate for packaging, air in the PVC plate is pumped out by using a vacuum pumping machine, the tablets are placed into a low-temperature drying refrigeration house for storage after the vacuum pumping is finished, and the effective period of the preparation can be effectively prolonged.
Drawings
FIGS. 1-5 are schematic flow diagrams of the present invention.
Detailed Description
The present invention will be described in further detail with reference to the following examples:
example 1
As shown in fig. 1-5, the invention provides a preparation method of a marine organism health-preserving and health-care peptide preparation, which comprises the following steps: step one, processing raw materials, namely processing sea cucumber raw materials to prepare the sea cucumber raw materials into powder;
step two, processing auxiliary materials, namely preheating the auxiliary materials to be added and mixing the auxiliary materials with the sea cucumber powder obtained in the step one; step three, finished product inspection is finished, the mixed preparation is inspected, and defective products are removed; and step four, storing the preparation, namely storing the preparation after inspection, wherein in the step one, 200-300 g of sea cucumber raw material is taken and placed in a crusher to be crushed for 20-3 min, meanwhile, an air cooler is utilized to maintain the temperature of the sea cucumber raw material in the crusher to be 3-5 ℃, the sea cucumber raw material is subjected to low-temperature shearing, in the step one, 100-500 g of protease is added into the sea cucumber powder after low-temperature shearing, the protease and the sea cucumber powder generate biochemical metabolic reaction, macromolecular protein in the sea cucumber powder is converted into small molecular protein active peptide, various amino acid sequencing bioactive peptides with different molecular mass sizes are produced through the metabolism and fermentation conditions of microorganisms, and the biological enzymolysis is carried out on the sea cucumber powder.
In the embodiment, the sea cucumber raw material is placed in the crusher to be crushed, meanwhile, the air cooler is utilized to maintain the temperature of the sea cucumber raw material in the crusher at a low temperature state, the heat generated in the crushing process can be prevented from damaging the structure of biological protein, the biological active ingredients in the sea cucumber raw material are reserved to the greatest extent, then, protease is added into the sea cucumber powder after low-temperature shearing, the protease and the sea cucumber powder are subjected to biochemical metabolic reaction, macromolecular protein in the sea cucumber powder is converted into micromolecular protein active peptide, various amino acid sequencing bioactive peptides with different molecular mass sizes are produced through the metabolism and fermentation conditions of microorganisms, and the peptide content of the preparation is increased.
Example 2
As shown in fig. 1 to 5, on the basis of embodiment 1, the present invention provides a technical solution: preferably, 70-200 g of lactic acid bacteria are added into the sea cucumber powder after biological enzymolysis in the first step, micromolecular fishy substances participate in anabolism and are converted into macromolecular substances without fishy smell through metabolism of microorganisms to realize fishy smell removal, fermentation of the sea cucumber powder is realized, 700-800 g of oyster powder is prepared in the second step, the oyster powder and the sea cucumber powder are placed into a stirrer to be stirred for 10-20 min, after stirring is completed, 50-70 g of 95% ethanol is added into the mixture, then the mixture is heated in a water bath at 80-95 ℃ for 30-45 min, after the water bath is completed, the mixture is taken out, and the mixture is pressed into tablets by a press molding machine.
In the embodiment, lactobacillus is added into the sea cucumber powder after biological enzymolysis, micromolecular fishy substances participate in anabolism and are converted into fishy-free macromolecular substances through metabolism of microorganisms, the oyster powder and the sea cucumber powder are mixed in a mixer, ethanol is added into the mixture and heated in a water bath, the mixture is taken out after the water bath is finished, and the mixture is pressed into tablets by a press molding machine, so that the preparation can be accepted by the public.
Example 3
As shown in fig. 1 to 5, on the basis of embodiment 1, the present invention provides a technical solution: preferably, in the third step, randomly sampling the compression-molded tablets once every 30-40 seconds, observing whether the appearance of the sample is damaged or not, detecting the weight of the sample by using a balance, in the fourth step, putting the tablets after detection into a PVC plate for packaging, then pumping out air in the PVC plate by using a vacuumizing machine, boxing and storing the PVC after vacuum pumping is finished, and then putting the medicine box into a low-temperature dry refrigeration house, wherein the temperature of the refrigeration house is maintained at 4-6 ℃.
In this embodiment, random sampling is carried out to compression-molded tablet, whether there is the damage in the outward appearance of observation sample, recycle the balance and detect the weight of sample, reduce the probability that the defective products appear in the preparation, put into the PVC board and pack the tablet that will inspect and accomplish, recycle the air in the vacuumizer with the PVC board and take out, put into low temperature drying's freezer after the vacuum pumping is accomplished and keep it, reduce the interior biological activity of preparation, avoid the situation that the save time of preparation is too short.
The working principle of the preparation method of the marine organism health-preserving and health-care peptide preparation is described in detail below.
As shown in fig. 1-5, a sea cucumber raw material is placed in a pulverizer to be pulverized, meanwhile, an air cooler is used for maintaining the temperature of the sea cucumber raw material in the pulverizer at a low temperature state, the heat generated in the pulverizing process can be prevented from damaging the structure of biological protein, the biological active ingredients in the sea cucumber raw material are reserved to the maximum extent, then, protease is added into the sea cucumber powder subjected to low-temperature shearing, the protease and the sea cucumber powder are subjected to biochemical metabolic reaction, macromolecular protein in the sea cucumber powder is converted into small-molecular protein active peptide, various amino acid sequences and biological active peptides with different molecular mass sizes are produced under the metabolic and fermentation conditions of microorganisms, the peptide content of the preparation is increased, the biological activity is conveniently preserved, the peptide content of the preparation is increased, the lactobacillus is added into the sea cucumber powder subjected to biological enzymolysis, the metabolic action of the microorganisms is involved in anabolism and is converted into non-fishy smell substances to realize deodorization, the oyster powder and the sea cucumber powder are placed into a stirrer to be mixed, ethanol is added into the mixture, the mixture is heated in a fishy smell-removing tablet, the mixture is pressed into a vacuum molding machine by a vacuum molding machine, the mixture is further, the PVC preparation is subjected to be subjected to a vacuum, and subjected to a vacuum test, and a waste product with the defect detection, and a waste product with the characteristic of a waste water bath, and a waste product is detected.
The present invention has been described in general terms, but it will be apparent to those skilled in the art that modifications and improvements can be made based on the present invention. Therefore, modifications or improvements are within the scope of the invention without departing from the spirit of the inventive concept.
Claims (7)
1. A preparation method of a marine organism health-preserving health-care peptide preparation is characterized by comprising the following steps: step one, processing raw materials, namely processing sea cucumber raw materials to prepare the sea cucumber raw materials into powder;
step two, processing auxiliary materials, namely preheating the auxiliary materials to be added and mixing the auxiliary materials with the sea cucumber powder obtained in the step one;
step three, finished product inspection is finished, the mixed preparation is inspected, and defective products are removed;
step four, storing the preparation, namely storing the preparation after the detection.
2. The preparation method of the marine organism health-preserving health-care peptide preparation according to claim 1, which is characterized by comprising the following steps: in the first step, 200-300 g of sea cucumber raw material is taken and placed in a grinder to be ground for 20-3 min, and meanwhile, an air cooler is used for maintaining the temperature of the sea cucumber raw material in the grinder at 3-5 ℃, so that the sea cucumber raw material is subjected to low-temperature shearing.
3. The preparation method of the marine organism health-preserving health-care peptide preparation according to claim 2, which is characterized by comprising the following steps: in the first step, 100-500 g of protease is added into the sea cucumber powder which is cut at low temperature, the protease and the sea cucumber powder generate biochemical metabolic reaction, macromolecular protein in the sea cucumber powder is converted into micromolecular protein active peptide, various biological active peptides with different amino acid sequences and molecular mass sizes are produced under the metabolism and fermentation conditions of microorganisms, and the biological enzymolysis is carried out on the sea cucumber powder.
4. The preparation method of the marine organism health-preserving health-care peptide preparation according to claim 3, which is characterized by comprising the following steps: in the first step, 70-200 g of lactic acid bacteria are added into the sea cucumber powder after biological enzymolysis, and through the metabolism of microorganisms, micromolecular fishy substances participate in anabolism and are converted into non-fishy macromolecular substances to realize fishy smell removal, so that the fishy smell of the sea cucumber powder is removed through fermentation.
5. The preparation method of the marine organism health-preserving health-care peptide preparation according to claim 1, which is characterized by comprising the following steps: preparing 700-800 g of oyster powder in the second step, then putting the oyster powder and the sea cucumber powder into a stirrer to be stirred for 10-20 min, after the stirring is finished, adding 50-70 g of 95% ethanol into the mixture, then heating in a water bath at 80-95 ℃ for 30-45 min, after the water bath is finished, taking out the mixture, and pressing the mixture into tablets by using a press molding machine.
6. The preparation method of the marine organism health-preserving health-care peptide preparation according to claim 5, which is characterized by comprising the following steps: and in the third step, randomly sampling the compression-molded tablets every 30-40 s, observing whether the appearance of the sample is damaged or not, and detecting the weight of the sample by using a balance.
7. The preparation method of the marine organism health-preserving health-care peptide preparation according to claim 6, which is characterized by comprising the following steps: and in the fourth step, the checked tablets are placed into a PVC plate for packaging, then a vacuumizing machine is used for pumping out air in the PVC plate, the PVC is packed into boxes for storage after vacuum pumping is finished, then the medicine boxes are placed into a low-temperature dry refrigeration house, and the temperature of the refrigeration house is maintained at 4-6 ℃.
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Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101015361A (en) * | 2007-02-10 | 2007-08-15 | 中国海洋大学 | Instant sea cucumber infusion and its preparing process |
| CN105296584A (en) * | 2015-10-09 | 2016-02-03 | 烟台源力德海洋生物有限公司 | Preparation method of marine biological health care peptide preparation |
| CN109371088A (en) * | 2018-12-21 | 2019-02-22 | 河北肽都生物科技有限公司 | A kind of preparation method of sea cucumber active peptide |
| CN111084346A (en) * | 2019-12-23 | 2020-05-01 | 谢海峰 | Preparation process of sea cucumber tablet and sea cucumber tablet prepared by preparation process |
| CN113817791A (en) * | 2021-09-18 | 2021-12-21 | 威海德尚医中医药科技有限公司 | Formula and preparation method of sea cucumber and oyster extract micromolecular peptide |
-
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- 2022-10-20 CN CN202211289077.6A patent/CN115918770A/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101015361A (en) * | 2007-02-10 | 2007-08-15 | 中国海洋大学 | Instant sea cucumber infusion and its preparing process |
| CN105296584A (en) * | 2015-10-09 | 2016-02-03 | 烟台源力德海洋生物有限公司 | Preparation method of marine biological health care peptide preparation |
| CN109371088A (en) * | 2018-12-21 | 2019-02-22 | 河北肽都生物科技有限公司 | A kind of preparation method of sea cucumber active peptide |
| CN111084346A (en) * | 2019-12-23 | 2020-05-01 | 谢海峰 | Preparation process of sea cucumber tablet and sea cucumber tablet prepared by preparation process |
| CN113817791A (en) * | 2021-09-18 | 2021-12-21 | 威海德尚医中医药科技有限公司 | Formula and preparation method of sea cucumber and oyster extract micromolecular peptide |
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