CN115844009A - 2911 plant component-containing composition and preparation method of honeysuckle extract containing 2911 plant component - Google Patents

2911 plant component-containing composition and preparation method of honeysuckle extract containing 2911 plant component Download PDF

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CN115844009A
CN115844009A CN202211130430.6A CN202211130430A CN115844009A CN 115844009 A CN115844009 A CN 115844009A CN 202211130430 A CN202211130430 A CN 202211130430A CN 115844009 A CN115844009 A CN 115844009A
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powder
plant
content
honeysuckle
honeysuckle extract
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孙涛垒
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Beijing Yuanlu Health Technology Co ltd
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Beijing Yuanlu Health Technology Co ltd
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Abstract

The invention relates to a composition containing 2911 plant elements and a preparation method of a honeysuckle extract containing 2911 plant elements, belonging to the field of compositions and traditional Chinese medicine extracts. The honeysuckle extract containing 2911 plant elements comprises an extracting solution and extract solid powder, and the preparation method of the honeysuckle extracting solution containing 2911 plant elements comprises the following steps: pulverizing and drying a honeysuckle sample to obtain honeysuckle powder, putting the honeysuckle powder into a container filled with water for decocting to obtain a decoction, and collecting and filtering the decoction to obtain a honeysuckle extracting solution. Concentrating under reduced pressure flos Lonicerae extractive solution containing 2911 plant elements to obtain flos Lonicerae concentrated solution, and drying to obtain flos Lonicerae extract solid powder. The honeysuckle extract containing 2911 plant elements is used as an effective component to prepare various beverages and medicines, has good taste, has the functions of broad-spectrum antibiosis, antivirus and the like, and has a certain application prospect.

Description

2911 plant component-containing composition and preparation method of honeysuckle extract containing 2911 plant component
Technical Field
The invention relates to a composition containing 2911 plant elements and a preparation method of a honeysuckle extract containing 2911 plant elements.
Background
The honeysuckle is a dry bud of Lonicera Japonica (Lonicera Japonica Thunb) of Caprifoliaceae, has sweet and cold property, enters lung, heart and stomach channels, has long medicinal history, is called as 'antibiotics in traditional Chinese medicine', and has the effects of clearing heat, detoxicating and dispelling wind and heat.
The 2020 edition of Chinese pharmacopoeia discloses the standard specifications of a honeysuckle dew finished formula preparation and a single-ingredient preparation.
According to the standard specification 1, 62.5g of honeysuckle is taken, steam distillation is carried out, about 1000ml of distillate is collected, the pH value of the distillate is adjusted to about 4.5, a proper amount of flavoring agent is added, filtration is carried out, 1000ml of distillate is prepared, and the honeysuckle tea is filled and sealed, sterilized or sterilized and filled and sealed to obtain the honeysuckle tea.
According to the standard specification 2, 100g of honeysuckle is taken, steam distillation is carried out, 1400ml of distillate is collected, a proper amount of simple syrup is added to 1600ml, and the mixture is filtered, encapsulated and sterilized; or taking 140g of cane sugar and 3.2g of sodium benzoate, adding water to dissolve, adding the mixture into the distillate, adding water to 1600ml, uniformly mixing, adding a proper amount of citric acid to adjust the pH value to 4.0-4.5, uniformly mixing, filtering, sterilizing and encapsulating to obtain the compound.
And according to the standard specification of 3, 100g of honeysuckle is taken, steam distillation is carried out, 1600ml of distillate is collected, 30g of cane sugar is added, and the honeysuckle is uniformly mixed, filtered, encapsulated and sterilized to obtain the honeysuckle health-care beverage.
The reference substance for identifying the honeysuckle dew prescription preparation and the single preparation is linalool.
The product prepared according to the 2020 edition of Chinese pharmacopoeia comprises honeysuckle flower distillate (national standard Z42020517) produced by the limited company of Longzhong of sunflower pharmaceutical industry group (Xiangyang) (the components of the honeysuckle flower distillate are honeysuckle flower, sucrose, sodium benzoate and citric acid) and honeysuckle flower distillate (national standard Z42021971) produced by the limited company of pharmaceutical industry at noon in Hubei province (the components of the honeysuckle flower distillate are honeysuckle flower, sucrose, sodium benzoate and citric acid).
In recent years, more researches are carried out on chemical components and bioactive substances of honeysuckle, and modern pharmacological researches show that the honeysuckle has the pharmacological effects of broad-spectrum antibiosis, antivirus, antipyretic, anti-inflammatory, liver protection, cholagogic, hemostasis and the like. However, the existing research results mainly focus on chemical monomers such as chlorogenic acid, isochlorogenic acid and caffeoylquinic acid contained in the effective components of honeysuckle. The stipulation of identifying the honeysuckle dew finished product preparation and the single preparation by using linalool as a reference substance in the Chinese pharmacopoeia reflects the limitation of the prior art and the product on the utilization of the effective components of honeysuckle.
Chinese granted patent No. CN 104922187B discloses a honeysuckle oral liquid and a preparation method thereof; the invention is based on that the effective components of honeysuckle flower comprise organic acids, flavonoids, triterpenoid saponins, volatile oil, trace elements and the like, wherein chlorogenic acid and volatile oil are taken as main components. The preparation method disclosed in CN 104922187B is to divide the steam distillation extraction into two times, finish the extraction of volatile components for 1 hour for the first time, filter the decoction in the distiller, and extract the residue for the second time; the extraction method can obtain extract with chlorogenic acid content increased by about 5% compared with the existing method.
In summary, the honeysuckle flower distillate in the Chinese pharmacopoeia or the honeysuckle flower oral liquid disclosed in the patent both reserve or improve the content of organic acids, especially chlorogenic acid, in the honeysuckle flower extract as much as possible. For this purpose, CN 104922187B requires that the decoction time of honeysuckle should be completed within one hour; that is, when the decoction time of honeysuckle exceeds one hour, the chlorogenic acid is destroyed, and the quality of the honeysuckle oral liquid is reduced.
Micronucleic acids (microRNAs) are a class of non-coding single-stranded RNA molecules of about 20-25 nucleotides in length encoded by endogenous genes, which are involved in the regulation of post-transcriptional gene expression in animals and plants.
It was found that 10g of honeysuckle was decocted in 100ml of water for 30 minutes to give a decoction of about 50 ml; the existence of micro nucleic acid 2911 (miR 2911) molecules is found in the decoction (the nucleotide sequence of miR2911 is 5-. Further studies found that the decoction containing miR2911 can inhibit influenza a virus (Zhou 2015).
Micro nucleic acid molecules are generally unstable. Although the miR2911 molecule is a special case and has certain stability, the decoction liquid containing the miR2911 molecule is prepared by limiting the time for decocting honeysuckle in water to 30 minutes (Zhou 2015), which indicates that the longer decoction time is likely to cause adverse effect on the stability of micro nucleic acid such as miR2911 molecule; meanwhile, whether the content of micro nucleic acid such as miR2911 molecules in the decoction can be improved by adjusting the decocting conditions such as time is unknown; how the decoction time influences the content of micro nucleic acids such as miR2911 molecules in the decoction is unpredictable.
Disclosure of Invention
The invention provides a2911 plant element-containing composition and a preparation method of a honeysuckle extract containing 2911 plant elements, including an extracting solution and solid powder.
The objects and advantages of the present invention will become apparent from the following detailed description of the preferred embodiments, taken in conjunction with the accompanying drawings.
Drawings
Preferred embodiments according to the present invention will now be described with reference to the accompanying drawings, in which like reference numerals refer to like elements.
FIG. 1 shows the relationship between the decoction time of honeysuckle and 2911 plant elements.
FIG. 2 shows the relationship between the decoction time and the taste of honeysuckle.
Detailed Description
In order to make the objects, technical solutions and advantages of the present invention more apparent, the present invention is further described in detail with reference to the following embodiments. It should be understood that the description is intended to be exemplary only, and is not intended to limit the scope of the present invention. Moreover, in the following description, descriptions of well-known structures and techniques are omitted so as to not unnecessarily obscure the concepts of the present invention.
In the present application, "plant element" refers to a kind of functional molecules of micro nucleic acid (microRNA) containing specific sequences, which are derived from plants, obtained by decoction or other special processes, and beneficial to human health. For example, "2911 plant element" refers to a micro nucleic acid 2911 (miR 2911) and derivatives thereof, which are derived from parts of flowers, stems, leaves and the like (such as tea leaves and the like) of traditional Chinese medicine honeysuckle or other plants and contain modification groups (such as methylation modification, glycosylation modification and the like).
The inventor of the invention explores the stability of 2911 plant elements in the honeysuckle extraction process, particularly the influence of the decoction time on the content of 2911 plant elements in the honeysuckle extract and the extract solid powder. Researches find that 2911 plant elements have stability in the honeysuckle extraction process, when the decoction time is 80 minutes, the 2911 plant elements reach 75% of the highest value, and when the decoction time is 30 minutes, the 2911 plant elements do not reach 20% of the highest value; after 60 min of decoction, 2911 the content of plant elements was about 40% of the highest value.
The inventor of the invention also explores the influence of the decoction time on the mouthfeel of the composition, in particular the beverage, prepared by the honeysuckle extract and the extract solid powder. It was found that the mouthfeel decreased significantly when the decocting time exceeded 180 minutes (e.g. 200 minutes).
From the combined effect of the two, the invention provides a preparation method of the honeysuckle extract and the extract solid powder containing 2911 plant elements.
In some embodiments, the method for preparing the extract solution of honeysuckle containing 2911 plant elements comprises:
crushing and drying the honeysuckle sample to obtain honeysuckle powder; in some embodiments, the honeysuckle flower powder is 10-200 mesh in size;
decocting flos Lonicerae powder in a distiller filled with water to obtain decoction with water amount multiple of 5-50 times, decoction temperature of 90-121 deg.C, and time of 15-200 min; ( Note: the temperature range mainly takes into consideration plateau areas and high-pressure environments )
Collecting and filtering the decoction to obtain honeysuckle extract; in some examples, the filtration is performed by bag filtration, with a pore size of 1-100. Mu.m.
In some embodiments, the preparation method of solid powder of honeysuckle extract containing 2911 plant elements comprises:
concentrating the flos Lonicerae extractive solution under reduced pressure to obtain flos Lonicerae concentrated solution at 30-95 deg.C and 0-0.1MPa; the concentration multiple is 2-100 times
Drying the honeysuckle concentrated solution to obtain honeysuckle extract solid powder, wherein the temperature range for drying is 100-250 ℃; in some embodiments, the manner of drying is spray drying.
Under the preparation process condition of the invention, 2911 plant elements of the honeysuckle extract solid powder have high yield which can reach more than 3000 pmol/g.
The invention also provides compositions comprising 2911 plant elements.
In some embodiments, the 2911 plant element-containing composition comprises water and 2911 plant elements, wherein said 2911 plant elements are in a content ranging from 1pmol/L to 1000000pmol/L, preferably, 1pmol/L to 100pmol/L,1pmol/L to 1000pmol/L,1pmol/L to 10000pmol/L,1pmol/L to 100000pmol/L.
In some embodiments, a composition comprising 2911 plant elements comprises 2911 plant elements and maltodextrin, wherein 2911 plant elements are present in an amount ranging from 10 -8 g/g to 0.999g/g, preferably 10 -8 g/g-0.0000009g/g，10 -8 g/g-0.000009g/g，10 -8 g/g-0.00009g/g，10 -8 g/g-0.0009g/g，10 -8 g/g-0.009g/g，10 -8 g/g-0.099g/g; wherein the content of the maltodextrin is in the range of 0.001-0.95g/g.
In some embodiments, a composition comprising 2911 plant elements comprises 2911 plant elements and a resistant starch, wherein 2911 plant elements are present in an amount ranging from 10 -8 g/g to 0.999g/g, preferably 10 -8 g/g-0.0000009g/g，10 -8 g/g-0.000009g/g，10 -8 g/g-0.00009g/g，10 -8 g/g-0.0009g/g，10 -8 g/g-0.009g/g，10 -8 g/g-0.099g/g; wherein the content of the resistant starch is in the range of 0.001-0.80g/g.
In some embodiments, a composition comprising 2911 plant units comprises 2911 plant units and fruit powder, wherein 2911 plant units are present in an amount ranging from 10 -8 g/g to 0.999g/g, preferably 10 -8 g/g-0.0000009g/g，10 -8 g/g-0.000009g/g，10 -8 g/g-0.00009g/g，10 -8 g/g-0.0009g/g，10 -8 g/g-0.009g/g，10 -8 g/g-0.099g/g; wherein the content range of the fruit powder is 0.001-0.80g/g. In some embodiments, the fruit powder is obtained by squeezing fruit, filtering to obtain juice, concentrating, and drying, and comprises fructus Persicae powder and fructus PyriFruit powder, cherry fruit powder, mango fruit powder, pineapple fruit powder, apple fruit powder, sweet orange fruit powder, strawberry fruit powder, blueberry fruit powder, passion fruit powder, watermelon fruit powder and the like.
In some embodiments, a composition comprising 2911 plant units comprises 2911 plant units and white sugar, wherein the 2911 plant units are present in an amount ranging from 10 -8 g/g to 0.999g/g, preferably 10 -8 g/g-0.0000009g/g，10 -8 g/g-0.000009g/g，10 -8 g/g-0.00009g/g，10 -8 g/g-0.0009g/g，10 -8 g/g-0.009g/g，10 -8 g/g-0.099g/g; wherein the content range of the white granulated sugar is 0.001-0.30g/g.
In some embodiments, a composition comprising 2911 plant elements comprises 2911 plant elements and fructose, wherein the 2911 plant elements are present in an amount ranging from 10 -8 g/g to 0.999g/g, preferably 10 -8 g/g-0.0000009g/g，10 -8 g/g-0.000009g/g，10 -8 g/g-0.00009g/g，10 -8 g/g-0.0009g/g，10 -8 g/g-0.009g/g，10 -8 g/g-0.099g/g; wherein the fructose content is in the range of 0.001-0.30g/g.
In some embodiments, a composition comprising 2911 plant elements comprises 2911 plant elements and glucose, wherein 2911 plant elements are present in an amount ranging from 10 -8 g/g to 0.999g/g, preferably 10 -8 g/g-0.0000009g/g，10 -8 g/g-0.000009g/g，10 -8 g/g-0.00009g/g，10 -8 g/g-0.0009g/g，10 -8 g/g-0.009g/g，10 -8 g/g-0.099g/g; wherein the content of glucose is in the range of 0.001-0.30g/g.
In some embodiments, a composition comprising 2911 plant elements comprises 2911 plant elements and maltitol, wherein 2911 plant elements are present in an amount ranging from 10 -8 g/g to 0.999g/g, preferably 10 -8 g/g-0.0000009g/g，10 -8 g/g-0.000009g/g，10 -8 g/g-0.00009g/g，10 -8 g/g-0.0009g/g，10 -8 g/g-0.009g/g，10 -8 g/g-0.099g/g; wherein the content of maltitol is in the range of 0.001-0.40g/g.
In some embodiments, a composition package containing 2911 plant elements2911-containing plant components and xylitol, wherein the 2911 plant components are contained in the range of 10 -8 g/g to 0.999g/g, preferably 10 -8 g/g-0.0000009g/g，10 -8 g/g-0.000009g/g，10 -8 g/g-0.00009g/g，10 -8 g/g-0.0009g/g，10 -8 g/g-0.009g/g，10 -8 g/g-0.099g/g; wherein the content range of the xylitol is 0.001-0.40g/g.
In some embodiments, the 2911 plant matter containing composition comprises water and 2911 plant matter containing solid powder of honeysuckle extract, wherein the solid powder of honeysuckle extract containing 2911 plant matter contains in an amount ranging from 0.01g/L to 500g/L, preferably from 0.01g/L to 1g/L, from 0.01g/L to 5g/L, from 0.01g/L to 10g/L, from 0.01g/L to 50g/L, from 0.01g/L to 100g/L, from 0.01g/L to 200g/L; wherein 2911 phyton content in the solid powder of honeysuckle extract containing 2911 phyton is 1pmol/g-1000000pmol/g, preferably, 1pmol/L-100pmol/L,1pmol/L-1000pmol/L,1pmol/L-10000pmol/L,1pmol/L-100000pmol/L.
In some embodiments, the 2911 plant-derived composition comprises water, fruit juice, and 2911 plant-derived honeysuckle extract solid powder, wherein the 2911 plant-derived honeysuckle extract solid powder is in an amount ranging from 0.01g/L to 500g/L, preferably, 0.01g/L to 1g/L,0.01g/L to 5g/L,0.01g/L to 10g/L,0.01g/L to 50g/L,0.01g/L to 100g/L,0.01g/L to 200g/L; wherein 2911 phyton content in the solid powder of honeysuckle extract containing 2911 phyton is 1pmol/g to 1000000pmol/g, preferably, 1pmol/L to 100pmol/L,1pmol/L to 1000pmol/L,1pmol/L to 10000pmol/L,1pmol/L to 100000pmol/L; the content of the fruit juice is in the range of 0.01-300g/L, preferably 0.01-200g/L,0.01-100g/L,0.01-50g/L,0.01-10g/L,0.01-1g/L. In some embodiments, the juice is a beverage prepared from fruit by physical methods such as squeezing, centrifuging, extracting, etc. The fruit juice retains most of the nutrients in the fruit, such as vitamins, minerals, sugar, pectin in dietary fiber, etc., and most pure fruit juices are concentrated fruit juices. The fruit juice comprises white peach juice, pear juice, cherry juice, mango juice, pineapple juice, apple juice, sweet orange juice, strawberry juice, blueberry juice, passion fruit juice, watermelon juice and the like.
In some embodiments, the 2911 plant-derived composition comprises water, white sugar and 2911 plant-derived honeysuckle extract solid powder, wherein the 2911 plant-derived honeysuckle extract solid powder content ranges from 0.01g/L to 500g/L, preferably from 0.01g/L to 1g/L, from 0.01g/L to 5g/L, from 0.01g/L to 10g/L, from 0.01g/L to 50g/L, from 0.01g/L to 100g/L, from 0.01g/L to 200g/L; wherein 2911 phyton content in the solid powder of honeysuckle extract containing 2911 phyton is 1pmol/g to 1000000pmol/g, preferably, 1pmol/L to 100pmol/L,1pmol/L to 1000pmol/L,1pmol/L to 10000pmol/L,1pmol/L to 100000pmol/L; the content range of the white granulated sugar is 0.01-300g/L, preferably 0.01-200g/L,0.01-100g/L,0.01-50g/L,0.01-10g/L and 0.01-1g/L.
In some embodiments, 2911 plant element-containing composition comprises water, fructose and 2911 plant element-containing solid powder of honeysuckle extract, wherein the 2911 plant element-containing solid powder of honeysuckle extract is in a solid content range of 0.01g/L to 500g/L, preferably 0.01g/L to 1g/L,0.01g/L to 5g/L,0.01g/L to 10g/L,0.01g/L to 50g/L,0.01g/L to 100g/L,0.01g/L to 200g/L; wherein 2911 plant components in the solid powder of honeysuckle extract containing 2911 plant components comprises 1pmol/g to 1000000pmol/g, preferably, 1pmol/L to 100pmol/L,1pmol/L to 1000pmol/L,1pmol/L to 10000pmol/L,1pmol/L to 100000pmol/L; the content of fructose is in the range of 0.01-300g/L, preferably 0.01-200g/L,0.01-100g/L,0.01-50g/L,0.01-10g/L,0.01-1g/L.
In some embodiments, the 2911 plant-derived composition comprises water, glucose and 2911 plant-derived honeysuckle extract solid powder, wherein the 2911 plant-derived honeysuckle extract solid powder is contained in an amount ranging from 0.01g/L to 500g/L, preferably, 0.01g/L to 1g/L,0.01g/L to 5g/L,0.01g/L to 10g/L,0.01g/L to 50g/L,0.01g/L to 100g/L,0.01g/L to 200g/L; wherein 2911 phyton content in the solid powder of honeysuckle extract containing 2911 phyton is 1pmol/g to 1000000pmol/g, preferably, 1pmol/L to 100pmol/L,1pmol/L to 1000pmol/L,1pmol/L to 10000pmol/L,1pmol/L to 100000pmol/L; the content range of the glucose is 0.01-300g/L, preferably 0.01-200g/L,0.01-100g/L,0.01-50g/L,0.01-10g/L and 0.01-1g/L.
In some embodiments, the 2911 plant-derived composition comprises water, maltitol, and solid powder of honeysuckle extract containing 2911 plant-derived elements, wherein the solid powder of honeysuckle extract containing 2911 plant-derived elements is in an amount ranging from 0.01g/L to 500g/L, preferably, 0.01g/L to 1g/L,0.01g/L to 5g/L,0.01g/L to 10g/L,0.01g/L to 50g/L,0.01g/L to 100g/L,0.01g/L to 200g/L; wherein 2911 phyton content in the solid powder of honeysuckle extract containing 2911 phyton is 1pmol/g to 1000000pmol/g, preferably, 1pmol/L to 100pmol/L,1pmol/L to 1000pmol/L,1pmol/L to 10000pmol/L,1pmol/L to 100000pmol/L; the content of maltitol is in the range of 0.01-300g/L, preferably 0.01-200g/L,0.01-100g/L,0.01-50g/L,0.01-10g/L,0.01-1g/L.
In some embodiments, the 2911 plant element-containing composition comprises water, xylitol and solid powder of honeysuckle extract containing 2911 plant elements, wherein the solid powder of honeysuckle extract containing 2911 plant elements is in the range of 0.01g/L to 500g/L, preferably 0.01g/L to 1g/L,0.01g/L to 5g/L,0.01g/L to 10g/L,0.01g/L to 50g/L,0.01g/L to 100g/L,0.01g/L to 200g/L; wherein 2911 phyton content in the solid powder of honeysuckle extract containing 2911 phyton is 1pmol/g to 1000000pmol/g, preferably, 1pmol/L to 100pmol/L,1pmol/L to 1000pmol/L,1pmol/L to 10000pmol/L,1pmol/L to 100000pmol/L; the content range of the xylitol is 0.01-300g/L, preferably 0.01-200g/L,0.01-100g/L,0.01-50g/L,0.01-10g/L and 0.01-1g/L.
In some embodiments, the 2911 plant-derived composition comprises water, erythritol, and 2911 plant-derived honeysuckle extract solid powder, wherein the 2911 plant-derived honeysuckle extract solid powder is contained in an amount ranging from 0.01g/L to 500g/L, preferably, 0.01g/L to 1g/L,0.01g/L to 5g/L,0.01g/L to 10g/L,0.01g/L to 50g/L,0.01g/L to 100g/L,0.01g/L to 200g/L; wherein 2911 phyton content in the solid powder of honeysuckle extract containing 2911 phyton is 1pmol/g to 1000000pmol/g, preferably, 1pmol/L to 100pmol/L,1pmol/L to 1000pmol/L,1pmol/L to 10000pmol/L,1pmol/L to 100000pmol/L; the content of erythritol is in the range of 0.01-300g/L, preferably 0.01-200g/L,0.01-100g/L,0.01-50g/L,0.01-10g/L,0.01-1g/L.
In some embodiments, the 2911 plant element-containing composition comprises water and a honeysuckle extract containing 2911 plant elements, wherein the 2911 plant element-containing honeysuckle extract is in a concentration range of 0.01ml/L to 1000ml/L, preferably 0.01ml/L to 10ml/L,0.01ml/L to 20ml/L,0.01ml/L to 30ml/L,0.01ml/L to 40ml/L,0.01ml/L to 50ml/L,0.01ml/L to 100ml/L; wherein 2911 plant components in the extract of honeysuckle flower containing 2911 plant components is 1pmol/g-1000000pmol/g, preferably, 1pmol/L-100pmol/L,1pmol/L-1000pmol/L,1pmol/L-10000pmol/L,1pmol/L-100000pmol/L.
In some embodiments, the 2911 plant matter-containing composition comprises solid powder of honeysuckle extract containing 2911 plant matter, wherein the solid powder of honeysuckle extract containing 2911 plant matter is present in an amount of 1000g/kg.
In some embodiments, the 2911 plant-derived composition comprises maltodextrin and 2911 plant-derived solid powder, wherein the 2911 plant-derived solid powder comprises honeysuckle extract solid powder in an amount ranging from 0.01g/L to 999.99g/L, preferably, 0.01g/L to 1g/L,0.01g/L to 5g/L,0.01g/L to 10g/L,0.01g/L to 50g/L,0.01g/L to 100g/L,0.01g/L to 500g/L; wherein 2911 phyton content in the solid powder of honeysuckle extract containing 2911 phyton is 1pmol/g to 1000000pmol/g, preferably, 1pmol/L to 100pmol/L,1pmol/L to 1000pmol/L,1pmol/L to 10000pmol/L,1pmol/L to 100000pmol/L; the content range of the maltodextrin is 0.01g/L-300g/L, preferably 0.01g/L-1g/L,0.01g/L-5g/L,0.01g/L-10g/L,0.01g/L-50g/L,0.01g/L-100g/L and 0.01g/L-300g/L.
In some embodiments, the 2911 plant-derived composition comprises resistant starch and 2911 plant-derived solid powder of honeysuckle extract, wherein the 2911 plant-derived solid powder of honeysuckle extract has a content in the range of 0.01g/L to 999.99g/L, preferably 0.01g/L to 1g/L,0.01g/L to 5g/L,0.01g/L to 10g/L,0.01g/L to 50g/L,0.01g/L to 100g/L,0.01g/L to 500g/L; wherein 2911 phyton content in the solid powder of honeysuckle extract containing 2911 phyton is 1pmol/g to 1000000pmol/g, preferably, 1pmol/L to 100pmol/L,1pmol/L to 1000pmol/L,1pmol/L to 10000pmol/L,1pmol/L to 100000pmol/L; the content range of the resistant starch is 0.01g/L-300g/L, preferably 0.01g/L-1g/L,0.01g/L-5g/L,0.01g/L-10g/L,0.01g/L-50g/L,0.01g/L-100g/L and 0.01g/L-300g/L.
In some embodiments, the 2911 plant-derived composition comprises fruit powder and 2911 plant-derived solid powder of honeysuckle extract, wherein the 2911 plant-derived solid powder of honeysuckle extract has a content in the range of 0.01g/L to 999.99g/L, preferably 0.01g/L to 1g/L,0.01g/L to 5g/L,0.01g/L to 10g/L,0.01g/L to 50g/L,0.01g/L to 100g/L,0.01g/L to 500g/L; wherein 2911 phyton content in the solid powder of honeysuckle extract containing 2911 phyton is 1pmol/g to 1000000pmol/g, preferably, 1pmol/L to 100pmol/L,1pmol/L to 1000pmol/L,1pmol/L to 10000pmol/L,1pmol/L to 100000pmol/L; the fruit powder comprises one or more of white peach fruit powder, pear fruit powder, cherry fruit powder, mango fruit powder, pineapple fruit powder, apple fruit powder, sweet orange fruit powder, strawberry fruit powder, blueberry fruit powder, passion fruit powder and watermelon fruit powder, and the content ranges from 0.01g/L to 300g/L, preferably 0.01g/L to 1g/L,0.01g/L to 5g/L,0.01g/L to 10g/L,0.01g/L to 50g/L,0.01g/L to 100g/L and 0.01g/L to 300g/L.
In some embodiments, the 2911 plant-derived material-containing composition comprises white granulated sugar and 2911 plant-derived material-containing honeysuckle extract solid powder, wherein the 2911 plant-derived material-containing honeysuckle extract solid powder content ranges from 0.01g/L to 999.99g/L, preferably from 0.01g/L to 1g/L, from 0.01g/L to 5g/L, from 0.01g/L to 10g/L, from 0.01g/L to 50g/L, from 0.01g/L to 100g/L, from 0.01g/L to 500g/L; wherein 2911 phyton content in the solid powder of honeysuckle extract containing 2911 phyton is 1pmol/g to 1000000pmol/g, preferably, 1pmol/L to 100pmol/L,1pmol/L to 1000pmol/L,1pmol/L to 10000pmol/L,1pmol/L to 100000pmol/L; the content range of the white granulated sugar is 0.01g/L-300g/L, preferably 0.01g/L-1g/L,0.01g/L-5g/L,0.01g/L-10g/L,0.01g/L-50g/L,0.01g/L-100g/L and 0.01g/L-300g/L.
In some embodiments, the 2911 plant-derived composition comprises fructose and 2911 plant-derived solid honeysuckle extract powder, wherein the 2911 plant-derived solid honeysuckle extract powder is in an amount ranging from 0.01g/L to 999.99g/L, preferably 0.01g/L to 1g/L,0.01g/L to 5g/L,0.01g/L to 10g/L,0.01g/L to 50g/L,0.01g/L to 100g/L,0.01g/L to 500g/L; wherein 2911 phyton content in the solid powder of honeysuckle extract containing 2911 phyton is 1pmol/g to 1000000pmol/g, preferably, 1pmol/L to 100pmol/L,1pmol/L to 1000pmol/L,1pmol/L to 10000pmol/L,1pmol/L to 100000pmol/L; the content range of the fructose is 0.01g/L-300g/L, preferably 0.01g/L-1g/L,0.01g/L-5g/L,0.01g/L-10g/L,0.01g/L-50g/L,0.01g/L-100g/L and 0.01g/L-300g/L.
In some embodiments, 2911 plant element-containing composition comprises glucose and solid powder of honeysuckle extract containing 2911 plant elements, wherein the solid powder of honeysuckle extract containing 2911 plant elements is in the range of 0.01g/L to 999.99g/L, preferably 0.01g/L to 1g/L,0.01g/L to 5g/L,0.01g/L to 10g/L,0.01g/L to 50g/L,0.01g/L to 100g/L,0.01g/L to 500g/L; wherein 2911 phyton content in the solid powder of honeysuckle extract containing 2911 phyton is 1pmol/g to 1000000pmol/g, preferably, 1pmol/L to 100pmol/L,1pmol/L to 1000pmol/L,1pmol/L to 10000pmol/L,1pmol/L to 100000pmol/L; the content range of the glucose is 0.01g/L-300g/L, preferably 0.01g/L-1g/L,0.01g/L-5g/L,0.01g/L-10g/L,0.01g/L-50g/L,0.01g/L-100g/L and 0.01g/L-300g/L.
In some embodiments, 2911 plant element-containing composition comprises maltitol and 2911 plant element-containing honeysuckle extract solid powder, wherein the 2911 plant element-containing honeysuckle extract solid powder content ranges from 0.01g/L to 999.99g/L, preferably 0.01g/L to 1g/L,0.01g/L to 5g/L,0.01g/L to 10g/L,0.01g/L to 50g/L,0.01g/L to 100g/L,0.01g/L to 500g/L; wherein 2911 phyton content in the solid powder of honeysuckle extract containing 2911 phyton is 1pmol/g to 1000000pmol/g, preferably, 1pmol/L to 100pmol/L,1pmol/L to 1000pmol/L,1pmol/L to 10000pmol/L,1pmol/L to 100000pmol/L; the content range of the maltitol is 0.01g/L-300g/L, preferably 0.01g/L-1g/L,0.01g/L-5g/L,0.01g/L-10g/L,0.01g/L-50g/L,0.01g/L-100g/L,0.01g/L-300g/L.
In some embodiments, the 2911 plant element-containing composition comprises xylitol and solid 2911 plant element-containing honeysuckle extract powder, wherein the solid 2911 plant element-containing honeysuckle extract powder is in a solid content ranging from 0.01g/L to 999.99g/L, preferably 0.01g/L to 1g/L,0.01g/L to 5g/L,0.01g/L to 10g/L,0.01g/L to 50g/L,0.01g/L to 100g/L,0.01g/L to 500g/L; wherein 2911 phyton content in the solid powder of honeysuckle extract containing 2911 phyton is 1pmol/g to 1000000pmol/g, preferably, 1pmol/L to 100pmol/L,1pmol/L to 1000pmol/L,1pmol/L to 10000pmol/L,1pmol/L to 100000pmol/L; the content range of the xylitol is 0.01g/L-300g/L, preferably 0.01g/L-1g/L,0.01g/L-5g/L,0.01g/L-10g/L,0.01g/L-50g/L,0.01g/L-100g/L and 0.01g/L-300g/L.
In some examples, compositions containing 2911 plant elements are formulated as in table 1.
TABLE 1, formulation A (liquid beverage)
Figure SMS_1
Figure SMS_2
In Table 1, the number 1 is a mandatory composition, and 2-6 can be combined arbitrarily, such as:
combination 1:1, 0.5g/L of honeysuckle extract (solid powder), 3.5 percent of 2 rock candy and 3 percent of 4 peach juice;
combination 2, 1, 0.3g/L of honeysuckle extract (solid powder), 5% of 2 erythritol, 0.1% of sucralose and 0.02% of 5% citric acid;
and (3) combination: 1, 1.2g/L of honeysuckle extract (solid powder), 5 percent of 2 erythritol, 5 percent of 3 emblic leafflower fruit, 2 percent of 4 pear juice and 0.03 percent of 5 malic acid;
and (4) combination: 1.12g/L of honeysuckle extract (solid powder), 2.5 percent of white granulated sugar, 3 percent of 4 peach juice and 80mg/L of 6 vitamin C;
and (3) combination 5:1, 1.68g/L of honeysuckle extract (solid powder), 5 percent of 2 erythritol, 3 percent of 3 perilla, 3 percent of 4 apple juice and 0.02 percent of 5 citric acid;
and (4) combination 6:1, 1.0g/L of honeysuckle extract (solid powder), 2, 4 percent of white granulated sugar, 1 percent of fructose, 4, 5 percent/L of apple juice and 0.03 percent of 5 citric acid;
combination 7:1, 1.12g/L of honeysuckle extract (solid powder), 6 percent of 2 erythritol, 6 percent of 3 polygonatum odoratum and 0.03 percent of 5 malic acid;
and (4) combination 8:1, 1.12g/L of honeysuckle extract (solid powder), 4 percent of 2 brown sugar, 2 percent of 3 longans, 2 percent of 4 orange juice and 0.03 percent of 5 malic acid;
combination 9:1 honeysuckle extract (solid powder) 100g/L,2 brown sugar 30%,3 emblic leafflower fruit 5%,4, orange juice 1.5%,5 malic acid 0.03%,6 vitamin C50 mg/L;
combination 10:1 honeysuckle extract (solid powder) 100g/L,2 white granulated sugar 5%, perilla 5%, vitamin C200 mg/L, malic acid 0.03%.
In some examples, compositions containing 2911 plant elements are formulated as in table 2.
TABLE 2, formulation B (extract)
Figure SMS_3
In Table 2, number 1 is the optional composition, 2-6 can be combined arbitrarily, such as:
combination 1:1, 200ml/L of honeysuckle extract (extracting solution), 3.5 percent of 2 rock candy and 3 percent of 4 peach juice;
combination 2, 1, 80ml/L of honeysuckle extract (extracting solution), 5% of 2 erythritol, 0.1% of sucralose and 0.02% of 5 citric acid;
combination 3:1, 250ml/L of honeysuckle extract (extracting solution), 5 percent of 2 erythritol, 5 percent of 3 emblic leafflower fruit, 2 percent of 4 pear juice and 0.03 percent of 5 malic acid;
and (4) combination: 1, 250ml/L of honeysuckle extract (extract), 3.5 percent of 2 white granulated sugar, 3 percent of 4 peach juice and 80mg/L of 6 vitamin C;
and (3) combination 5: 330ml/L of honeysuckle extract (extracting solution), 5% of 2 erythritol, 3% of 3 perilla, 3%/L of 4 apple juice and 0.02% of 5 citric acid;
and (4) combination 6:1 honeysuckle extract (extract) 200ml/L,2 white granulated sugar 4%, fructose 1%,4 apple juice 5%/L,5 citric acid 0.03%;
and (3) combination 7:1, 500ml/L of honeysuckle extract (extracting solution), 6 percent of 2 erythritol, 6 percent of 3 polygonatum odoratum and 0.03 percent of 5 malic acid;
and (4) combination 8:1, 500ml/L of honeysuckle extract (extracting solution), 4 percent of 2 brown sugar, 2 percent of 3 longans, 2 percent of 4 orange juice and 0.03 percent of 5 malic acid;
combination 9:1 honeysuckle extract (extract) 1000ml/L,2 blacksugar 30%,3 emblic leafflower fruit 5%, 4%, orange juice 1.5%,5 malic acid 0.03%,6 vitamin C50 mg/L;
combination 10: 1000ml/L of 1 honeysuckle extract (extracting solution), 6 percent of 2 white granulated sugar, 5 percent of purple perilla, 200mg/L of vitamin C and 0.03 percent of malic acid.
In some examples, compositions containing 2911 plant elements are formulated as in table 3.
TABLE 3, formulation C (solid beverage)
Figure SMS_4
Figure SMS_5
In Table 3, number 1 is the optional composition, 2-11 can be combined arbitrarily, such as:
combination 1:1 honeysuckle extract (solid powder) 150g/kg,2 emblic leafflower fruit extract 3 percent and 3 maltodextrin 82 percent;
combination 2:1 honeysuckle extract (solid powder) 100g/kg,3 maltodextrin 64.98%2 erythritol 5%,4 citric acid 0.02%,11 cherry powder 20%;
and (3) combination: 1 honeysuckle extract (solid powder) 100g/kg,3 maltodextrin 51.78%, 2% erythritol 5%,4 citric acid 0.02%,7 whey protein 8%,8 calcium carbonate 5%,9VC powder 0.2%,11 cherry powder 20%;
and (4) combination: 1 honeysuckle extract (solid powder) 200g/kg,3 maltodextrin 62.98%, 2% white granulated sugar 5%,4 malic acid 0.02%,8 gluconic acid zinc 2%,11 juicy peach fruit powder 10%.
The following embodiments are provided merely to illustrate the principles of the invention; they are in no way intended to limit the scope of the present invention.
Examples
Example 1 preparation of honeysuckle extract
4 g of dried honeysuckle, crushing, sieving by using a 40-mesh sieve to obtain honeysuckle powder, adding the honeysuckle powder into an extraction tank, adding water, wherein the ratio of the water to the honeysuckle powder is 30.
Dried honeysuckle flower 4 g, crushed to 40 meshes, extracted at 105 ℃ for 10,15,30,60, 80, 100,120,150,180 or 200 minutes, and filtered in a bag of 5 mu m to obtain honeysuckle extract liquid decocted for different time. 2911 plant component content was determined by fluorescent RT-PCR detection.
Dried honeysuckle flower 4 g, crushed to 40 meshes, extracted at 95 ℃ for 10,15,30,60, 80, 100,120,150,180 or 200 minutes, and filtered in a bag of 5 mu m to obtain honeysuckle extract liquid decocted for different time.
Example 2 preparation of solid powder of honeysuckle extract
The honeysuckle extract obtained in example 1 was concentrated under vacuum at-0.1 MPa/50 ℃, spray-dried at 180 ℃ and powdered. The solid powder yield (the weight of the obtained solid powder divided by the weight of the honeysuckle dried flower raw material) is 12-29%. 2911 plant component content was determined by fluorescent RT-PCR detection. 2911 plant component content of dried flos Lonicerae is 589-880pmol/g.
The results are shown in FIG. 1 (FIG. 1 shows 2911 plant components in the honeysuckle extract (solid powder)). The extraction temperature represented in FIG. 1 was 100 ℃.
Under the preparation process condition, 2911 plant elements in the honeysuckle extract solid powder have high content which can reach more than 3000 pmol/g.
Example 3 taste evaluation of honeysuckle extract and extract solid powder
For 60 target groups, each person tasted the decoction at different decoction times, and scored the tastes (1-positive, 0-negative), and the scores for each taste were summed up and plotted. The results are shown in FIG. 2.
Industrial applicability
The composition containing the miRNA2911 molecule may be used as a drink or a pharmaceutical. They are suitable for industrial applications.

Claims (12)

1. The preparation method of the honeysuckle extract containing 2911 plant elements is characterized by comprising the following steps:
crushing and drying the honeysuckle sample to obtain honeysuckle powder; the honeysuckle powder is 10-200 meshes in size;
decocting flos Lonicerae powder in water container to obtain decoction with water amount of 2-100 times, temperature of decoction of 90-121 deg.C, and time of 60-180 min;
collecting and filtering the decoction to obtain honeysuckle extract; the filtration is bag filtration with a pore size of 1-100 μm.
2. The preparation method of the honeysuckle extract solid powder containing 2911 plant elements is characterized by comprising the following steps of:
concentrating the extract of honeysuckle flower containing 2911 plant elements as defined in claim 1 under reduced pressure at 30-95 deg.C and 0-0.1MPa to obtain a concentrated honeysuckle flower solution; the concentration multiple is 2-100 times;
drying the honeysuckle concentrated solution to obtain honeysuckle extract solid powder, wherein the temperature range for drying is 100-250 ℃; the drying mode is spray drying.
3. A composition comprising 2911 plant elements, said composition comprising:
water;
2911 plant element, wherein the content of 2911 plant element is 1pmol/L-1000000pmol/L.
4. A composition comprising 2911 plant elements, said composition comprising:
2911 plant elements; 2911 plant element content range is 10 -8 g/g-0.999g/g；
One or more selected from maltodextrin, resistant starch, fruit powder, white sugar, fructose, glucose, maltitol and xylitol;
wherein the content ranges of the maltodextrin, the resistant starch, the fruit powder, the white granulated sugar, the fructose, the glucose, the maltitol and the xylitol are respectively 0.001-0.95g/g, 0.001-0.80g/g, 0.001-0.30g/g, 0.001-0.40g/g and 0.001-0.40g/g.
5. A composition comprising 2911 plant elements, said composition comprising:
water;
2911 plant element-containing honeysuckle extract solid powder, wherein the content of the 2911 plant element-containing honeysuckle extract solid powder ranges from 0.01g/L to 500g/L; 2911 plant components in the honeysuckle extract solid powder containing 2911 plant components are 1pmol/g-1000000pmol/g.
6. The composition of claim 5, comprising 2911 plant elements, wherein said composition further comprises:
one or more selected from fruit juice, white sugar, fructose, glucose, maltitol, xylitol and erythritol;
the content range of the fruit juice, the white granulated sugar, the fructose, the glucose, the maltitol, the xylitol and the erythritol is 0.01-300g/L.
7. A composition comprising 2911 plant elements, said composition comprising:
water;
2911 plant element-containing honeysuckle extract, wherein the content range of the 2911 plant element-containing honeysuckle extract is 0.01ml/L-1000ml/L; in the 2911 plant component-containing honeysuckle extract, the content of 2911 plant components is 1pmol/L-1000000pmol/L.
8. 2911 plant component-containing composition, which is characterized by comprising 2911 plant component-containing honeysuckle extract solid powder, wherein the content of the 2911 plant component-containing honeysuckle extract solid powder is 1000g/kg.
9. A composition comprising 2911 plant elements, said composition comprising:
2911 plant element-containing honeysuckle extract solid powder, wherein the content of the 2911 plant element-containing honeysuckle extract solid powder ranges from 0.01g/L to 999.99g/LL; 2911 plant components in the honeysuckle extract solid powder containing 2911 plant components are 1pmol/g-1000000pmol/g;
one or more selected from maltodextrin, resistant starch, fruit powder, white sugar, fructose, glucose, maltitol and xylitol; the content range of the maltodextrin, the resistant starch, the fruit powder, the white granulated sugar, the fructose, the glucose, the maltitol and the xylitol is 0.01g/L-300g/L.
10. A composition comprising 2911 plant elements, said composition comprising:
the honeysuckle extract solid powder containing 2911 plant elements as claimed in claim 2, in an amount of 0.01g/L-500g/L;
one or more selected from crystal sugar, sucrose, white sugar, brown sugar, fructose, glucose, erythritol and sucralose, with a content of 0-30%;
one or more of extractive solution or solid powder of fructus Phyllanthi, perillae herba, rhizoma Polygonati Odorati, arillus longan, rhizoma Dioscoreae, poria, coicis semen, fructus Lycii, rhizoma Polygonati, fructus Alpinae Oxyphyllae, bitter Citrus immature flower, pericarpium Citri Tangerinae, fructus Citri Sarcodactylis, fructus Citri, semen Pruni, folium Nelumbinis, radix Platycodi and semen Cassiae, with content of 0-30%;
one or more selected from succus Pyri, succus Mali Pumilae, succus Persicae, sucus Citri sinensis, succus Vitis Viniferae, succus Mangiferae Indicae, succus Cocois, succus Citri Limoniae, pineapple juice, succus Vitis Viniferae and succus Actinidiae chinensis, with content of 0-30%;
one or more selected from citric acid, malic acid and sodium citrate, with content of 0-5%;
vitamins with content of 0-200mg/L.
11. A composition comprising 2911 plant elements, said composition comprising:
the honeysuckle extract containing 2911 plant elements as claimed in claim 1, in an amount of 0.01ml/L to 1000ml/L;
one or more selected from crystal sugar, sucrose, white sugar, brown sugar, fructose, glucose, erythritol and sucralose, with a content of 0-12%;
one or more kinds selected from extractive solution or solid powder of fructus Phyllanthi, perillae herba, rhizoma Polygonati Odorati, arillus longan, rhizoma Dioscoreae, poria, coicis semen, fructus Lycii, rhizoma Polygonati, fructus Alpinae Oxyphyllae, bitter Citrus immature flower, pericarpium Citri Tangerinae, fructus Citri Sarcodactylis, fructus Citri, semen Pruni, folium Nelumbinis, radix Platycodi and semen Cassiae, with content of 0-30%;
one or more selected from succus Pyri, succus Mali Pumilae, succus Persicae, sucus Citri sinensis, succus Vitis Viniferae, succus Mangiferae Indicae, succus Cocois, succus Citri Limoniae, pineapple juice, grapefruit juice and kiwi fruit juice, and the content is 0-30%;
one or more selected from citric acid, malic acid and sodium citrate, with content of 0-5%;
vitamins with content of 0-200mg/L.
12. A composition comprising 2911 plant elements, said composition comprising:
the honeysuckle extract solid powder containing 2911 plant elements as claimed in claim 2, in an amount of 0.01g/kg-999.99g/kg;
one or more solid powders selected from fructus Phyllanthi, perillae herba, rhizoma Polygonati Odorati, arillus longan, rhizoma Dioscoreae, poria, coicis semen, fructus Lycii, rhizoma Polygonati, fructus Alpinae Oxyphyllae, bitter Citrus immature flower, pericarpium Citri Tangerinae, fructus Citri Sarcodactylis, fructus Citri, semen Pruni, folium Nelumbinis, radix Platycodi and semen Cassiae, with a content of 0-30%;
one or more selected from sucrose powder, white granulated sugar powder, maltodextrin, resistant dextrin, erythritol and sucralose, and the content is 0-25%;
one or more selected from citric acid, malic acid, lactic acid, tartaric acid and gluconic acid, with content of 0-10%;
one or more of fructo-oligosaccharide, galacto-oligosaccharide, isomalto-oligosaccharide, oat beta-glucan, xylo-oligosaccharide, soybean oligosaccharide and chito-oligosaccharide, and the content is 0-50%;
one or more selected from olive oil fat powder, linseed oil fat powder, perilla oil fat powder and DHA powder, and the content is 0-80%;
one or more selected from whey protein, isolated whey protein, casein and soybean protein isolate, with content of 0-80%;
one or more selected from calcium carbonate, ferrous gluconate, zinc gluconate and selenium yeast, and the content is 0-20%;
one or more selected from vitamin A powder, vitamin C powder and vitamin B powder, with content of 0-10%;
one or more selected from Bifidobacterium powder, lactobacillus rhamnosus powder and Lactobacillus paracasei powder, with content of 0-60%;
one or more selected from cherry powder, cranberry fruit powder, blueberry fruit powder and juicy peach fruit powder, and the content is 0-10%.
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