CN115814036A - Medicinal composition for invigorating spleen, calming liver, promoting digestion and stimulating appetite, preparation and application thereof - Google Patents
Medicinal composition for invigorating spleen, calming liver, promoting digestion and stimulating appetite, preparation and application thereof Download PDFInfo
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Abstract
The invention discloses a medicinal composition for tonifying spleen, calming liver, promoting digestion and stimulating appetite, and a preparation and application thereof, wherein the medicinal composition comprises the following components in parts by weight: 10-30 parts of fried radix bupleuri, 10-30 parts of white peony root, 10-30 parts of radix codonopsis, 10-30 parts of poria cocos, 10-30 parts of bighead atractylodes rhizome, 10-30 parts of fried rhizoma atractylodis, 10-30 parts of lotus seed, 10-30 parts of semen coicis, 10-30 parts of Chinese yam, 10-30 parts of scorched hawthorn fruit, 10-30 parts of fried malt, 10-30 parts of fried rice sprout, 5-10 parts of fructus amomi, 10-30 parts of fried hyacinth bean, 5-10 parts of dark plum fruit, 10-30 parts of uncaria, 5-10 parts of Chinese date and 5-10 parts of liquorice. The invention has the effects of strengthening spleen, calming liver, promoting digestion and stimulating appetite.
Description
Technical Field
The invention belongs to the field of medicines, and particularly relates to a medicinal composition for tonifying spleen and calming liver, and promoting digestion and appetite, and a preparation and application thereof.
Background
Anorexia is an independent disease and can also appear as a symptom in other diseases. Anorexia is a common disease of children, and the children with anorexia have a long-term loss of appetite and obviously reduced food intake. Chronic digestive dysfunction can be caused by long-term anorexia, and children patients have malnutrition, low immunity, anemia, recurrent respiratory tract infection, rickets, scurvy and the like, and the children patients have great influence on healthy growth. According to the research and discovery in recent years, the disease has an increasing trend and is worthy of clinical attention.
The western medicine usually adopts zinc supplementing treatment, gastrointestinal motility promoting drug treatment and the like, and the ideal treatment effect is not obtained too much. In traditional Chinese medicine, children suffering from anorexia are treated by differentiation of symptoms, and a more effective and safer traditional Chinese medicine treatment mode is researched very important.
The infantile anorexia is a common and frequently-occurring disease in pediatrics, and belongs to the categories of 'bad food', 'food retention', 'phlegm stagnation' and the like in traditional Chinese medicine. The clinical manifestations of the disease are chronic anorexia with chronic anorexia, anorexia and even food refusal. It is usually caused by improper feeding, spleen injury due to other diseases, congenital deficiency, emotional disorder, and the pathological changes of viscera mainly in the spleen and stomach. The stomach is covered and received, the spleen governs transportation and transformation, and the spleen and stomach harmonize, so the mouth can know the flavor of five-cereal food, as in Ling Shu, mai Wei (Ling Shu. Mai Du): "spleen qi is passed through the mouth, and spleen and mouth can tell the five cereals . The failure of spleen and stomach to receive and transform will cause anorexia. Qian Yi in "Children's herbal evidence formula" states: disharmony between the spleen and stomach, failure to feed milk and emaciation are caused. The inventor has carried out pediatric clinical, teaching and scientific research for more than 70 years. In the lengthy diagnosis and treatment process, the physiological characteristics of 'frequent insufficiency of the spleen and frequent excess of the liver' of the children are combined, the treatment of the child anorexia is summarized, the empirical formula of the medicinal composition for tonifying spleen, calming the liver, helping digestion and stimulating the appetite is summarized, and the medicinal composition has obvious curative effect on the child anorexia.
Disclosure of Invention
Aiming at the defects in the prior art, the invention aims to provide a pharmaceutical composition, a preparation and an application thereof. The pharmaceutical composition can be used for tonifying spleen, calming liver, promoting digestion and stimulating appetite.
The purpose of the invention is realized by the following technical scheme: a medicinal composition for tonifying spleen, calming liver, promoting digestion and stimulating appetite comprises the following components in parts by weight: 10-30 parts of fried radix bupleuri, 10-30 parts of white peony root, 10-30 parts of radix codonopsis, 10-30 parts of poria cocos, 10-30 parts of bighead atractylodes rhizome, 10-30 parts of fried rhizoma atractylodis, 10-30 parts of lotus seed, 10-30 parts of semen coicis, 10-30 parts of Chinese yam, 10-30 parts of scorched hawthorn fruit, 10-30 parts of fried malt, 10-30 parts of fried rice sprout, 5-10 parts of fructus amomi, 10-30 parts of fried hyacinth bean, 5-10 parts of dark plum fruit, 10-30 parts of uncaria, 5-10 parts of Chinese date and 5-10 parts of liquorice.
Preferably, the pharmaceutical composition comprises the following components in parts by weight: 15 to 25 parts of fried radix bupleuri, 5 to 25 parts of white paeony root, 15 to 25 parts of radix codonopsis, 15 to 25 parts of poria cocos, 15 to 25 parts of bighead atractylodes rhizome, 15 to 25 parts of fried rhizoma atractylodis, 15 to 25 parts of lotus seed, 15 to 25 parts of semen coicis, 15 to 25 parts of Chinese yam, 15 to 25 parts of scorched hawthorn fruit, 15 to 25 parts of fried malt, 15 to 25 parts of fried rice sprout, 5 to 8 parts of fructus amomi, 15 to 25 parts of fried hyacinth bean, 5 to 8 parts of dark plum fruit, 15 to 25 parts of uncaria, 5 to 8 parts of Chinese date and 5 to 8 parts of liquorice.
The preparation of the pharmaceutical composition is prepared by adding pharmaceutically acceptable auxiliary materials into the pharmaceutical composition.
Preferably, the preparation is in the form of decoction, granules, paste, capsules or pills prepared according to a conventional method.
A preparation method of a medicinal composition preparation for tonifying spleen, calming liver, promoting digestion and stimulating appetite comprises the following steps: the preparation of the pharmaceutical composition is a soft extract, and the preparation process comprises the following steps:
s1, decocting: soaking the medicinal composition in water for 1-4 hr, decocting for 2-3 times, filtering decoction after each decoction for 1-2 hr, squeezing decoction dregs, mixing squeezed liquid and filtered decoction, standing, clarifying, and filtering;
s2, concentrating: heating and concentrating the decoction to obtain fluid extract;
s3, refining honey: dissolving Mel in water, filtering, and heating and decocting to obtain refined Mel;
s4, collecting paste: adding refined honey into the clear paste, adding 300 g of refined honey into every 1000 g of clear paste, stirring, heating and decocting to obtain the paste in a white thread state.
The pharmaceutical composition is applied to the preparation of medicines for tonifying spleen, calming liver, promoting digestion and stimulating appetite.
The preparation of the pharmaceutical composition is applied to preparing medicines for tonifying spleen, calming liver, promoting digestion and stimulating appetite.
The invention has the beneficial effects that: radix codonopsis pilosulae, rhizoma atractylodis macrocephalae, rhizoma atractylodis, lotus seed, semen coicis, white hyacinth bean, yam and fructus amomi have the functions of promoting appetite and activating spleen, fried radix bupleuri, radix paeoniae alba and uncaria have the function of calming the liver, smoked plum has the functions of nourishing stomach yin, endothelium corneum gigeriae galli has the functions of promoting digestion and removing food stagnation, and liquorice has the functions of harmonizing the medicines in the recipe. The whole formula is used together to play the effects of invigorating spleen, calming liver, promoting digestion and stimulating appetite.
Detailed Description
The present invention will be further described with reference to the following examples, but the present invention is not limited to these examples.
The first purpose of the invention is realized by comprising the following components in parts by weight: 10-30 parts of fried radix bupleuri, 10-30 parts of white peony root, 10-30 parts of radix codonopsis, 10-30 parts of poria cocos, 10-30 parts of bighead atractylodes rhizome, 10-30 parts of fried rhizoma atractylodis, 10-30 parts of lotus seed, 10-30 parts of semen coicis, 10-30 parts of Chinese yam, 10-30 parts of scorched hawthorn fruit, 10-30 parts of fried malt, 10-30 parts of fried rice sprout, 5-10 parts of fructus amomi, 10-30 parts of fried hyacinth bean, 5-10 parts of dark plum fruit, 10-30 parts of uncaria, 5-10 parts of Chinese date and 5-10 parts of liquorice.
Preferably, the pharmaceutical composition comprises the following components in parts by weight: 15-25 parts of fried radix bupleuri, 5-25 parts of white peony root, 15-25 parts of radix codonopsis, 15-25 parts of poria cocos, 15-25 parts of bighead atractylodes rhizome, 15-25 parts of fried rhizoma atractylodis, 15-25 parts of lotus seed, 15-25 parts of semen coicis, 15-25 parts of Chinese yam, 15-25 parts of scorched hawthorn fruit, 15-25 parts of fried malt, 15-25 parts of fried rice sprout, 5-8 parts of fructus amomi, 15-25 parts of fried hyacinth bean, 5-8 parts of dark plum fruit, 15-25 parts of uncaria, 5-8 parts of Chinese date and 5-8 parts of liquorice.
The second purpose of the invention is realized by adding pharmaceutically acceptable auxiliary materials into the pharmaceutical composition to prepare the pharmaceutical composition preparation.
Preferably, the pharmaceutical composition is prepared in the form of decoction, granules, capsules or pills prepared according to a conventional method.
The third object of the present invention is achieved by a method for preparing a formulation of said pharmaceutical composition, comprising the steps of:
the preparation of the pharmaceutical composition is a soft extract, and the preparation process comprises the following steps:
s1, decocting: soaking the medicinal composition in water for 1-4 hr, decocting for 2-3 times, filtering decoction after each decoction for 1-2 hr, squeezing decoction dregs, mixing squeezed liquid and filtered decoction, standing, clarifying, and filtering;
s2, concentrating: heating and concentrating the decoction to obtain fluid extract;
s3, refining honey: dissolving Mel in water, filtering, and heating and decocting to obtain refined Mel;
s4, collecting paste: adding refined honey into the clear paste, adding 300 g of refined honey into every 1000 g of clear paste, stirring, heating and decocting to obtain the paste in a white thread state.
The clear paste is concentrated and is dripped on mulberry paper, and the best condition is that no water seeps around the dripping.
In the honey refining process, honey is heated until light yellow glossy billowing uniform fine bubbles appear, the honey is twisted by hands to have viscosity, and no white thread appears optimally when two fingers are separated.
In the paste collecting process, the refined honey is added and then is stirred clockwise, and foams on the liquid surface need to be fished out when the paste is heated.
The white thread making is that the paste is dripped on the forefinger and twisted with the thumb together, and the white thread with the length of about 2cm can be pulled out.
The soft extract is prepared, subpackaged in clean, dry and sterilized wide-mouth containers, covered and sealed after being sufficiently cooled, and stored in a shade place.
The fourth purpose of the invention is realized by the application of the pharmaceutical composition in preparing medicines for tonifying spleen, calming liver, promoting digestion and stimulating appetite.
The fifth purpose of the invention is realized by the application of the preparation of the pharmaceutical composition in preparing medicines for tonifying spleen, calming liver, promoting digestion and stimulating appetite.
In the application, the codonopsis pilosula in Lu, the bighead atractylodes rhizome and the rhizoma atractylodis are monarch drugs and have the effects of strengthening spleen and replenishing qi; the fried radix bupleuri, the white paeony root and the uncaria are used as ministerial drugs for nourishing and calming the liver. Lotus seed, coix seed, white hyacinth bean, yam and amomum fruit are used as adjuvant drugs for stimulating appetite and activating spleen, dark plum fruit is used for nourishing stomach yin, chicken's gizzard-membrane is used for promoting digestion and removing food stagnation, and liquorice is used for harmonizing the drugs of the recipe. The whole formula is used together to play the effects of invigorating spleen, calming liver, promoting digestion and stimulating appetite.
Parching radix bupleuri: bitter, pungent and slightly cold. It enters liver and gallbladder meridians. Has the effects of dispelling pathogenic wind, relieving fever, soothing liver, relieving depression, and invigorating yang.
Parched bupleuri radix has effect in dispelling liver qi stagnation. The effective components of bupleuri radix have effects of inhibiting gastric acid secretion, resisting ulcer, inhibiting trypsin, resisting fatty liver, exciting smooth muscle of intestine, increasing protein biosynthesis, resisting tumor and enhancing immunity.
White peony root: bitter, sour, sweet and slightly cold. It enters liver and spleen meridians. Has the functions of nourishing blood, regulating menstruation, calming liver, relieving pain, astringing yin and arresting sweating. Paeoniflorin has inhibitory effect on gastrointestinal smooth muscle, and radix Paeoniae alba has spasmolytic effect on inhibiting parasympathetic excitability; also has obvious inhibition effect on the peptic ulcer. Also has liver protecting effect.
Radix codonopsis pilosulae: sweet and neutral. It enters spleen and lung meridians. Has the effects of benefiting qi, promoting production of body fluid and nourishing blood. The effective components of radix Codonopsis can promote gastric ulcer healing, has antibacterial effect, and can enhance immunity.
Tuckahoe, poria cocos: sweet, bland and mild. It enters heart, spleen and kidney meridians. The effects of promoting diuresis, eliminating dampness, invigorating spleen and tranquilizing mind. The main chemical components of tuckahoe comprise tuckahoe triterpenes and pachyman, and the tuckahoe has various pharmacological actions of resisting inflammation, resisting oxidation, resisting tumor, regulating immunity and the like.
White atractylodes rhizome: bitter, sweet and warm. It enters spleen and stomach meridians. Has effects in invigorating qi, invigorating spleen, eliminating dampness, promoting diuresis, arresting sweating, and preventing miscarriage. Atractylodis rhizoma has effects of regulating intestinal canal activity, protecting liver, promoting bile flow, promoting urination, reducing blood sugar, resisting blood coagulation, resisting bacteria, and resisting tumor.
Parching rhizoma atractylodis: pungent, bitter and warm. It enters spleen and stomach meridians. Has the effects of eliminating dampness, strengthening spleen and expelling wind-damp. Atractylol has the function of promoting gastrointestinal motility and has weak contraction effect on smooth muscles of stomach. The volatile oil can inhibit intestinal spasm caused by parasympathetic nerve mediator acetylcholine.
Lotus seed: sweet, astringent and neutral. It enters spleen, kidney and heart meridians. Has the effects of tonifying kidney, controlling nocturnal emission, tonifying spleen, stopping diarrhea, stopping leukorrhagia and nourishing heart. The main chemical components of the lotus seed are alkaloid, flavonoid, polysaccharide, volatile oil and the like, and the lotus seed has the effects of reducing blood fat, stopping bleeding, resisting inflammation, resisting oxidation and thrombus, protecting liver, lung and kidney, protecting central nervous system and the like.
Coix seed: sweet, bland and slightly cold. It enters spleen, stomach and lung meridians. Induce diuresis and drain dampness, invigorate spleen, remove arthralgia, clear heat and expel pus. Coix seed contains fatty acids and various compounds such as esters, polysaccharides, flavones, triterpenes, alkaloids, etc. Has effects in regulating intestinal flora, enhancing immunity, relieving pain, relieving inflammation, and resisting oxidation.
Chinese yam: sweet in flavor, neutral in nature, enters spleen, lung and kidney meridians. Has the effects of supplementing qi, nourishing yin, invigorating spleen, lung and kidney, and arresting seminal emission. The main chemical components of the Chinese yam comprise various compounds such as polysaccharide, amino acid, fatty acid and the like, and the Chinese yam has pharmacological effects of reducing blood sugar, reducing blood fat, resisting oxidation, regulating spleen and stomach, resisting tumors, regulating immunity and the like.
Charring the hawthorn: sour, sweet and warm. It enters spleen, stomach and liver meridians. Has the functions of promoting digestion, eliminating food stagnation, promoting qi circulation and dissipating blood stasis. The fatty acid contained in the hawthorn can promote fat digestion, increase the secretion of digestive enzyme in stomach to promote digestion, and has a certain regulation effect on gastrointestinal function. Also has effects in resisting blood platelet aggregation, resisting oxidation, enhancing immunity, promoting urination, tranquilizing mind, contracting uterus, and inhibiting bacteria.
And (3) malt frying: sweet and neutral. It enters spleen, stomach and liver meridians. Has the effects of promoting digestion, invigorating stomach, promoting lactation and relieving flatulence. The malt contains various active ingredients, mainly comprises polysaccharides, enzymes, alkaloids, vitamins and the like, and has the effects of helping digestion, promoting sex hormone secretion, regulating intestinal flora, resisting platelet aggregation, protecting liver and the like.
And (3) stir-frying rice sprouts: sweet and neutral. It enters spleen and stomach meridians. Promoting digestion and invigorating stomach. The contained amylase can effectively promote digestion.
Amomum fruit: pungent and warm. It enters spleen and stomach meridians. Has the effects of resolving dampness, promoting qi circulation, warming middle energizer, relieving vomiting, stopping diarrhea and preventing miscarriage. Fructus Amomi can promote secretion of digestive juice, promote intestinal tract movement, inhibit blood platelet aggregation, resist ulcer, and relieve pain.
Stir-frying hyacinth beans: sweet and warm. It enters spleen and stomach meridians. Has the functions of invigorating spleen, eliminating dampness and relieving summer heat. The effective components of semen lablab album have antibacterial, toxic materials clearing away, antiviral, and immunity improving effects.
Dark plum: sour, astringent and neutral. It enters liver, spleen, lung and large intestine meridians. Has the effects of astringing lung to stop cough, astringing intestine to stop diarrhea, relieving ascaris to stop pain, promoting the production of body fluid to quench thirst. The dark plum mainly contains chemical components such as organic acid, terpenes, sterols and the like. Has antibacterial, blood lipid reducing, antioxidant, antitumor, and anticoagulant effects.
Uncaria: sweet and slightly cold. It enters liver and pericardium meridians. Has the effects of extinguishing wind and relieving spasm, clearing heat and calming liver. The ramulus Uncariae cum uncis contains rhynchophylline as effective component, and has pharmacological effects of protecting nerve, lowering blood pressure, protecting myocardium, relieving pain, resisting inflammation, relieving asthma, etc.
Chinese date: sweet and warm. It enters spleen and stomach meridians. Tonify middle-jiao and Qi, nourish blood and soothe the nerves, and alleviate the property of the medicine. The Chinese date contains organic acid and triterpene glycoside chemical components, and has pharmacological effects of increasing gastrointestinal mucus, protecting liver, tranquilizing, hypnotizing, etc.
Licorice root: sweet and neutral. It enters heart, lung, spleen and stomach meridians. Has the effects of tonifying qi and strengthening the middle-jiao, clearing away heat and toxic material, eliminating phlegm and stopping cough, relieving spasm and pain and harmonizing drug property. The licorice has various chemical components and wide pharmacological actions of resisting tumor, inflammation, bacteria, virus, liver protection, etc.
The present invention will be further described with reference to the following examples, but the present invention is not limited to these examples.
Example 1
A pharmaceutical composition comprises the following components in parts by weight: 10g of fried radix bupleuri, 10g of white paeony root, 10g of radix codonopsis pilosulae, 10g of tuckahoe, 10g of bighead atractylodes rhizome, 10g of fried rhizoma atractylodis, 10g of lotus seed, 10g of coix seed, 10g of yam, 15g of scorched hawthorn fruit, 15g of fried malt, 15g of fried rice sprout, 5g of fructus amomi, 15g of fried hyacinth bean, 5g of dark plum fruit, 15g of uncaria, 5g of Chinese date and 5g of liquorice.
Example 2
A pharmaceutical composition comprises the following components in parts by weight: 25g of fried radix bupleuri, 25g of white paeony root, 25g of radix codonopsis pilosulae, 25g of tuckahoe, 25g of bighead atractylodes rhizome, 25g of fried rhizoma atractylodis, 25g of lotus seed, 25g of coix seed, 25g of yam, 25g of scorched hawthorn fruit, 25g of fried malt, 25g of fried rice sprout, 8g of fructus amomi, 25g of fried hyacinth bean, 8g of dark plum fruit, 25g of uncaria, 8g of Chinese date and 8g of liquorice.
Example 3
A pharmaceutical composition comprises the following components in parts by weight: 20g of fried radix bupleuri, 10g of white paeony root, 18g of radix codonopsis pilosulae, 18g of tuckahoe, 18g of bighead atractylodes rhizome, 20g of fried rhizoma atractylodis, 18g of lotus seed, 20g of coix seed, 20g of yam, 20g of scorched hawthorn fruit, 20g of fried malt, 20g of fried rice sprout, 6g of fructus amomi, 20g of fried hyacinth bean, 6g of dark plum fruit, 20g of uncaria, 6g of Chinese date and 6g of liquorice.
Example 4
A pharmaceutical composition comprises the following components in parts by weight: 18g of fried radix bupleuri, 18g of white paeony root, 20g of radix codonopsis pilosulae, 20g of tuckahoe, 20g of bighead atractylodes rhizome, 20g of fried rhizoma atractylodis, 20g of lotus seed, 20g of coix seed, 18g of yam, 18g of scorched hawthorn fruit, 18g of fried malt, 18g of fried rice sprout, 8g of fructus amomi, 25g of fried hyacinth bean, 8g of dark plum fruit, 30g of uncaria, 9g of Chinese date and 9g of liquorice.
Example 5
A pharmaceutical composition comprises the following components in parts by weight: 20g of fried radix bupleuri, 25g of white paeony root, 20g of radix codonopsis pilosulae, 15g of tuckahoe, 15g of bighead atractylodes rhizome, 15g of fried rhizoma atractylodis, 15g of lotus seed, 15g of coix seed, 18g of yam, 18g of scorched hawthorn fruit, 15g of fried malt, 15g of fried rice sprout, 5g of fructus amomi, 20g of fried hyacinth bean, 6g of dark plum fruit, 20g of uncaria, 6g of Chinese date and 6g of liquorice.
Example 6
A pharmaceutical composition comprises the following components in parts by weight: 30g of fried radix bupleuri, 30g of white paeony root, 30g of radix codonopsis pilosulae, 30g of tuckahoe, 30g of bighead atractylodes rhizome, 30g of fried rhizoma atractylodis, 30g of lotus seed, 30g of coix seed, 30g of yam, 30g of scorched hawthorn fruit, 30g of fried malt, 30g of fried rice sprout, 10g of fructus amomi, 30g of fried hyacinth bean, 10g of dark plum fruit, 30g of uncaria, 10g of Chinese date and 10g of liquorice.
The application embodiment of the pharmaceutical composition is used for tonifying spleen, calming liver, promoting digestion and stimulating appetite.
1. Research method
Patients meeting the inclusion standard of child anorexia in nearly five years are selected, the pharmaceutical composition is used for treatment, and the clinical curative effect and adverse reactions are observed.
2. Diagnostic criteria
Refer to the guideline for clinical research of new Chinese medicine (1993 version).
3. Standard of Western diagnosis
The appetite of the children is reduced, the appetite is reduced by more than 1/2 compared with the constant amount, the duration is more than 2 weeks, and except anorexia caused by other system diseases.
4. Traditional Chinese medicine syndrome diagnosis standard
Syndrome of spleen deficiency with liver hyperactivity: anorexia or apastia, dry and irritability, restlessness, excessive crying, bruxism, loose stools, scanty urine, abdominal distension, fatigue, lusterless or sallow complexion, and emaciation.
The main symptoms are: anorexia, anorexia or apastia for a long time.
The secondary symptoms are as follows: dry and irritative, sallow complexion, fatigue, abdominal distension.
Tongue pulse: pale-red or red tongue with white or little coating.
5. Inclusion criteria
1. Meets the traditional Chinese medicine and western medicine diagnosis standards of infantile anorexia.
2. The year is 1-12 years old.
3. No other medications were used.
6. Exclusion criteria
1. The aversion to food caused by other systemic diseases cannot be excluded.
2. Allergic constitution or allergic to the medicine
3. Combined with primary diseases of cardiovascular, cerebrovascular, liver, kidney and hemopoietic system, and psychonosebleed.
4. If the drug dose is not in accordance with the inclusion criteria, the efficacy of the drug cannot be judged, or the data is incomplete, which affects the efficacy or safety of the drug.
7. Administration and dosage (dosage of decoction, granule, paste, capsule or pill)
The dosage of the ointment is 1-3 years old: 5g each time, three to four times per day; 3-7 years old: 8g each time, three to four times per day; 7-12 years old: 10g each time, three to four times daily.
8. Criteria for therapeutic effect
1. And (3) healing: the appetite and food intake are both restored to normal levels.
2. The effect is shown: the appetite was clearly restored and the food intake was restored to 3/4 of the normal level.
3. The method has the following advantages: the appetite is improved, and the appetite is recovered, but the appetite is not 3/4 of the normal appetite.
4. And (4) invalidation: the appetite and the food intake are not improved.
9. Summary of clinical effects
The patients with child anorexia are observed for 100 cases, wherein 28 cases are cured clinically, 32 cases are effective, 35 cases are effective, and 5 cases are ineffective.
11. Adverse reaction
The clinical application shows that the medicine has no toxic side effect and adverse reaction.
12. [ PROBABILITY ] it should be used with cautions for those who suffer from exogenous fever.
13. Typical cases
1. Jiang Mou, male, age 8. The doctor diagnoses 5 months and 7 days in 2019. Children with food intake deficiency, poor appetite, abdominal distension, loose stool, strange spleen-qi, emaciation. Pale with white coating. The pulse is slow. The diagnosis is as follows: anorexia (spleen deficiency, liver hyperactivity, food stagnation), is indicated for spleen-invigorating, liver-calming, digestion-promoting and appetite-stimulating. After taking 5 doses, the stomach absorption is good, the abdominal distension and the spleen qi strange disappear. The original prescription is added with 10 doses (traditional Chinese medicine decoction pieces), and the disease is cured.
2. Old, female, 15 years old. Visit in 2021, 6 months and 4 days. The patient does not eat due to the large examination pressure in about 1 month, and has a small amount of food for each meal, nausea, loose stool and emaciation when eating too much. Pale with white coating. The pulse is slow. Anorexia (liver depression, spleen deficiency, spleen dysfunction in transportation, stomach dysfunction in descending), and can be used for soothing liver, strengthening spleen, regulating stomach function. 10 doses of the original prescription are decocted into paste (ointment) which is taken 3 times a day, 10 grams of the paste is taken once, and the paste is mixed with boiled water for taking. After the medicine is taken, the appetite is improved, and the disease is cured.
3. Wang Mou, male, age 36. The doctor visits 8 months and 10 days in 2021. Patients have slight carelessness in diet, diarrhea, 3 to 4 times a day, no formation, dull pain in the abdomen before diarrhea, good safety after diarrhea, irritability, poor appetite, emaciation and poor spirit. Pale with greasy coating. The diarrhea is diagnosed as the spleen deficiency and liver hyperactivity, and the transportation and transformation are not right.
Treating the following steps: calming liver, invigorating spleen, regulating stomach function, and relieving diarrhea, and is administered 1 hr after meal, 3 times a day, one bag (granule) at a time. After 20 doses of the medicine are taken, the disease is basically cured, and the excrement is normal due to slight carelessness of diet.
The above cases are only partial cases observed in clinic, the used pharmaceutical composition is also only partial pharmaceutical composition, and the dosage of the specific drug in the pharmaceutical composition can be arbitrarily selected within the scope of the present invention according to different clinical symptoms of patients in actual clinical use.
Claims (10)
1. The pharmaceutical composition is characterized by comprising the following components in parts by weight: 10-30 parts of fried radix bupleuri, 10-30 parts of white peony root, 10-30 parts of radix codonopsis, 10-30 parts of poria cocos, 10-30 parts of bighead atractylodes rhizome, 10-30 parts of fried rhizoma atractylodis, 10-30 parts of lotus seed, 10-30 parts of semen coicis, 10-30 parts of Chinese yam, 10-30 parts of scorched hawthorn fruit, 10-30 parts of fried malt, 10-30 parts of fried rice sprout, 5-10 parts of fructus amomi, 10-30 parts of fried hyacinth bean, 5-10 parts of dark plum fruit, 10-30 parts of uncaria, 5-10 parts of Chinese date and 5-10 parts of liquorice.
2. The pharmaceutical composition according to claim 1, comprising the following components in parts by weight: 15-25 parts of fried radix bupleuri, 5-25 parts of white peony root, 15-25 parts of radix codonopsis, 15-25 parts of poria cocos, 15-25 parts of bighead atractylodes rhizome, 15-25 parts of fried rhizoma atractylodis, 15-25 parts of lotus seed, 15-25 parts of semen coicis, 15-25 parts of Chinese yam, 15-25 parts of scorched hawthorn fruit, 15-25 parts of fried malt, 15-25 parts of fried rice sprout, 5-8 parts of fructus amomi, 15-25 parts of fried hyacinth bean, 5-8 parts of dark plum fruit, 15-25 parts of uncaria, 5-8 parts of Chinese date and 5-8 parts of liquorice.
3. The preparation of the pharmaceutical composition of claim 1 or 2, wherein the pharmaceutical composition is formulated with pharmaceutically acceptable excipients.
4. The pharmaceutical composition of any one of claims 1 to 3, wherein the formulation is in the form of a decoction, granules, capsules or pills prepared according to conventional methods.
5. A method of preparing a formulation of a pharmaceutical composition according to claim 3, comprising the steps of:
the preparation of the pharmaceutical composition is a soft extract, and the preparation process comprises the following steps:
s1, decocting: soaking the medicinal composition in water for 1-4 hr, decocting for 2-3 times, filtering decoction after each decoction for 1-2 hr, squeezing decoction dregs, mixing squeezed solution and filtered decoction, standing, clarifying, and filtering;
s2, concentrating: heating and concentrating the decoction to obtain fluid extract;
s3, refining honey: dissolving Mel in water, filtering, and heating and decocting to obtain refined Mel;
s4, collecting paste: adding refined honey into the clear paste, adding 300 g of refined honey into every 1000 g of clear paste, stirring, heating and decocting to obtain the paste in a white thread state.
6. The preparation method of the pharmaceutical composition preparation according to claim 4, wherein the clear paste is concentrated, and the clear paste is dropped on mulberry paper, preferably when no water seeps around the drop.
7. A method for preparing a formulation of a pharmaceutical composition according to claim 4, wherein said honey is heated during said honey refining process until a yellowish shiny, uniform fine bubble is formed, which is tacky by twisting with the hand, and no white thread appears optimally when the two fingers are separated.
8. The method of preparing a formulation of a pharmaceutical composition according to claim 4,
the white thread making is that the paste liquid is dripped on the forefinger to be twisted with the thumb together, and the white thread with the length of about 2cm can be pulled out.
9. Use of a pharmaceutical composition according to any one of claims 1 to 2 for the preparation of a medicament for the treatment of spleen-invigorating, liver-calming, digestion-promoting and appetite-stimulating.
10. Use of a preparation of the pharmaceutical composition of any one of claims 4-6 for the preparation of a medicament for invigorating spleen, calming liver, promoting digestion, and stimulating appetite.
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107519414A (en) * | 2016-06-22 | 2017-12-29 | 江西江中食疗科技有限公司 | A kind of composition and preparation method thereof |
| CN112535714A (en) * | 2020-12-17 | 2021-03-23 | 上海中医药大学附属曙光医院 | Novel traditional Chinese medicine composition for treating infantile diarrhea and processing method |
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- 2022-09-18 CN CN202211133426.5A patent/CN115814036A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107519414A (en) * | 2016-06-22 | 2017-12-29 | 江西江中食疗科技有限公司 | A kind of composition and preparation method thereof |
| CN112535714A (en) * | 2020-12-17 | 2021-03-23 | 上海中医药大学附属曙光医院 | Novel traditional Chinese medicine composition for treating infantile diarrhea and processing method |
Non-Patent Citations (2)
| Title |
|---|
| 何雯等: "健脾剂治疗小儿厌食症50例临床观察", 中医儿科杂志, vol. 5, no. 4, pages 15 - 17 * |
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