CN115813878A - Water-proof coating solution and application for preparing water-proof capsule - Google Patents
Water-proof coating solution and application for preparing water-proof capsule Download PDFInfo
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- CN115813878A CN115813878A CN202211582642.8A CN202211582642A CN115813878A CN 115813878 A CN115813878 A CN 115813878A CN 202211582642 A CN202211582642 A CN 202211582642A CN 115813878 A CN115813878 A CN 115813878A
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- 239000002775 capsule Substances 0.000 title claims abstract description 131
- 238000000576 coating method Methods 0.000 title claims abstract description 99
- 239000011248 coating agent Substances 0.000 title claims abstract description 94
- HPEUJPJOZXNMSJ-UHFFFAOYSA-N Methyl stearate Chemical compound CCCCCCCCCCCCCCCCCC(=O)OC HPEUJPJOZXNMSJ-UHFFFAOYSA-N 0.000 claims abstract description 48
- IPCSVZSSVZVIGE-UHFFFAOYSA-N hexadecanoic acid Chemical compound CCCCCCCCCCCCCCCC(O)=O IPCSVZSSVZVIGE-UHFFFAOYSA-N 0.000 claims abstract description 48
- 235000013871 bee wax Nutrition 0.000 claims abstract description 33
- 239000012166 beeswax Substances 0.000 claims abstract description 33
- VLKZOEOYAKHREP-UHFFFAOYSA-N n-Hexane Chemical compound CCCCCC VLKZOEOYAKHREP-UHFFFAOYSA-N 0.000 claims abstract description 29
- 235000021314 Palmitic acid Nutrition 0.000 claims abstract description 24
- WQEPLUUGTLDZJY-UHFFFAOYSA-N n-Pentadecanoic acid Natural products CCCCCCCCCCCCCCC(O)=O WQEPLUUGTLDZJY-UHFFFAOYSA-N 0.000 claims abstract description 24
- CAMHHLOGFDZBBG-UHFFFAOYSA-N epoxidized methyl oleate Natural products CCCCCCCCC1OC1CCCCCCCC(=O)OC CAMHHLOGFDZBBG-UHFFFAOYSA-N 0.000 claims abstract description 23
- 238000000034 method Methods 0.000 claims description 11
- 238000001035 drying Methods 0.000 claims description 9
- 238000010438 heat treatment Methods 0.000 claims description 7
- 238000002156 mixing Methods 0.000 claims description 6
- 238000010992 reflux Methods 0.000 claims description 6
- 238000003756 stirring Methods 0.000 claims description 4
- 238000007711 solidification Methods 0.000 claims description 2
- 230000008023 solidification Effects 0.000 claims description 2
- 230000007306 turnover Effects 0.000 claims description 2
- 238000000465 moulding Methods 0.000 claims 1
- 239000003814 drug Substances 0.000 abstract description 21
- 230000006378 damage Effects 0.000 abstract description 10
- 239000007788 liquid Substances 0.000 abstract description 5
- 231100000956 nontoxicity Toxicity 0.000 abstract description 5
- 230000003115 biocidal effect Effects 0.000 abstract description 3
- 230000007547 defect Effects 0.000 abstract description 3
- 230000003064 anti-oxidating effect Effects 0.000 abstract description 2
- 230000015556 catabolic process Effects 0.000 abstract description 2
- 238000006731 degradation reaction Methods 0.000 abstract description 2
- 229940079593 drug Drugs 0.000 abstract description 2
- 230000002708 enhancing effect Effects 0.000 abstract description 2
- 235000016709 nutrition Nutrition 0.000 abstract description 2
- 230000035764 nutrition Effects 0.000 abstract description 2
- 108010010803 Gelatin Proteins 0.000 description 34
- 229920000159 gelatin Polymers 0.000 description 34
- 239000008273 gelatin Substances 0.000 description 34
- 235000019322 gelatine Nutrition 0.000 description 34
- 235000011852 gelatine desserts Nutrition 0.000 description 34
- 239000000243 solution Substances 0.000 description 24
- 238000012360 testing method Methods 0.000 description 15
- 239000000463 material Substances 0.000 description 12
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 12
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 9
- 238000013112 stability test Methods 0.000 description 8
- 230000000052 comparative effect Effects 0.000 description 6
- 239000011521 glass Substances 0.000 description 5
- 239000007766 cera flava Substances 0.000 description 3
- 239000002552 dosage form Substances 0.000 description 3
- 238000007689 inspection Methods 0.000 description 3
- 239000002245 particle Substances 0.000 description 3
- 238000002360 preparation method Methods 0.000 description 3
- 239000002994 raw material Substances 0.000 description 3
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 2
- 238000010521 absorption reaction Methods 0.000 description 2
- 238000011161 development Methods 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 239000003995 emulsifying agent Substances 0.000 description 2
- 230000002209 hydrophobic effect Effects 0.000 description 2
- YIXJRHPUWRPCBB-UHFFFAOYSA-N magnesium nitrate Chemical compound [Mg+2].[O-][N+]([O-])=O.[O-][N+]([O-])=O YIXJRHPUWRPCBB-UHFFFAOYSA-N 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 238000011056 performance test Methods 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 150000003626 triacylglycerols Chemical class 0.000 description 2
- 241000196324 Embryophyta Species 0.000 description 1
- 241000305491 Gastrodia elata Species 0.000 description 1
- 230000001133 acceleration Effects 0.000 description 1
- 230000004888 barrier function Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 230000018044 dehydration Effects 0.000 description 1
- 238000006297 dehydration reaction Methods 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 239000007903 gelatin capsule Substances 0.000 description 1
- 239000008187 granular material Substances 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 238000011068 loading method Methods 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 238000002844 melting Methods 0.000 description 1
- 230000008018 melting Effects 0.000 description 1
- 239000000546 pharmaceutical excipient Substances 0.000 description 1
- -1 polytetrafluoroethylene Polymers 0.000 description 1
- 229920001343 polytetrafluoroethylene Polymers 0.000 description 1
- 239000004810 polytetrafluoroethylene Substances 0.000 description 1
- 239000008213 purified water Substances 0.000 description 1
- 239000012047 saturated solution Substances 0.000 description 1
- 238000007493 shaping process Methods 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- UFTFJSFQGQCHQW-UHFFFAOYSA-N triformin Chemical compound O=COCC(OC=O)COC=O UFTFJSFQGQCHQW-UHFFFAOYSA-N 0.000 description 1
- 239000002023 wood Substances 0.000 description 1
Abstract
The invention discloses a waterproof coating solution and application for preparing a waterproof capsule, wherein the waterproof coating solution consists of beeswax, palmitic acid, methyl stearate and n-hexane; the mass ratio of the beeswax to the palmitic acid to the methyl stearate is 1; the volume dosage of the normal hexane is 0.5-5ml/g calculated by the mass of the beeswax; the edible waterproof coating has the characteristics of antibiosis, difficult damage, no toxicity and no harm, and can play a certain role in antioxidation and bacteriostasis, thereby greatly enhancing the application value of the edible waterproof coating. The edible waterproof coating is used for coating the inner wall of the capsule, is a capsule product capable of containing liquid contents, and compared with the traditional hollow capsule without the coating, the edible waterproof coating not only overcomes the defect that liquid medicines cannot be used in the capsule, but also can increase the intake of beeswax and improve nutrition, and has the characteristics of difficult damage, natural degradation, no toxicity and no harm.
Description
(I) the technical field
The invention relates to the field of special materials for capsules, in particular to a water-proof coating solution and application thereof in preparing water-proof capsules.
(II) background of the invention
The water-proof capsule coating is a medicinal coating material, has the characteristics of good water-proof performance, convenient use, good practicability and the like, is simple in manufacturing process, low in cost, edible and easy to degrade, is a medicinal coating material with great development potential, and has good development prospect.
Capsules are common pharmaceutical dosage forms. The empty capsules can be divided into capsules of animal origin and capsules of plant origin according to the material, and the most common empty capsules are gelatin empty capsules of animal origin. The gelatin hollow capsule is not dissolved in water, but slowly expands and softens when meeting water, and gradually absorbs water with the mass 5 to 10 times of the self mass, and the characteristic can ensure the good disintegration time of the hollow capsule, thereby achieving the effect of releasing the medicine in vivo. Some traditional Chinese medicine components also adopt gelatin hollow capsules as dosage forms, but because the traditional Chinese medicine has hygroscopicity, the moisture in the capsules can be transferred to the traditional Chinese medicine components, so that the moisture content of the traditional Chinese medicine components is increased, and the capsules can become fragile due to dehydration, so that the quality and the quality guarantee period of the whole medicine are reduced.
Disclosure of the invention
The invention aims to provide a water-proof coating solution and application of the water-proof coating solution in preparation of water-proof capsules, which can be applied to hollow capsules from all sources, overcomes the defect that the existing hollow capsules cannot meet the requirements of containing liquid medicaments into capsules, widens the dosage forms of the liquid medicaments, and improves the quality guarantee period and quality of the medicaments easy to absorb moisture.
The technical scheme adopted by the invention is as follows:
the invention provides a waterproof coating solution for the inner wall of a capsule, which is prepared from beeswax, palmitic acid, methyl stearate and n-hexane; the mass ratio of the beeswax to the palmitic acid to the methyl stearate is 1; the volume usage of the normal hexane is 0.5-5ml/g, preferably 1.5ml/g calculated by the mass of the beeswax.
The waterproof coating solution is prepared by the following method: heating and mixing the beeswax, the palmitic acid and the methyl stearate, and uniformly stirring until the beeswax, the palmitic acid and the methyl stearate are completely melted and mixed; and adding n-hexane, refluxing, heating and uniformly mixing to obtain a water-proof coating solution.
Preferably, the beeswax, the palmitic acid and the methyl stearate are melted and mixed by heating to 80 ℃; the reflux time after the n-hexane addition was 30min.
The invention also provides an application of the water-proof coating solution in preparing water-proof capsules, and the application method comprises the following steps:
and (3) coating the water-proof coating solution in the hollow capsule, standing for solidification, and drying to obtain the capsule coated with the water-proof coating inside.
Preferably, the water-proof coating solution is added into the hollow capsule in a dropping mode; the dripping is to open the hollow capsule cap, drip 5-6 drops of water-proof coating solution, buckle the capsule cap, turn over up and down to make the solution evenly spread on the inner wall of the capsule, stand, wait for the coating to fix and shape; and uniformly coating the solution on the inner wall of the capsule, covering a capsule cap, standing at room temperature, and fixing and forming the coating.
Preferably, the drying is carried out by opening the coated capsule and drying at 25 ℃ for 20 minutes.
Beeswax is a common strong hydrophobic substance, is in a solid state at normal temperature, is not easy to move and fall off, and is a main component for the water-resisting layer to play a role. Methyl stearate has certain hydrophobicity, and beeswax can soften and enhance the film forming property of the waterproof coating between the mixing of the beeswax and the methyl stearate, so that the methyl stearate has a certain emulsifier effect. The palmitic acid has a certain function of a shaping agent, so that the beeswax can be better shaped to enhance the stability of the waterproof coating. The n-hexane is used as a solvent, so that the beeswax, the palmitic acid and the methyl stearate can be fully fused, are volatile and can be removed easily after forming a coating.
The beeswax and the methyl stearate are both food-grade pharmaceutic adjuvants.
Compared with the prior art, the invention has the following beneficial effects:
the edible waterproof coating has the characteristics of antibiosis, difficult damage, no toxicity and no harm, and can play a certain role in antioxidation and bacteriostasis, thereby greatly enhancing the application value of the edible waterproof coating.
Compared with the traditional hollow capsule without the coating, the edible waterproof coating not only overcomes the defect that liquid medicines cannot be used in the capsule, but also can increase the intake of beeswax and improve nutrition, and has the characteristics of difficult damage, natural degradation, no toxicity and no harm.
(IV) detailed description of the preferred embodiments
The invention will be further described with reference to specific examples, but the scope of the invention is not limited thereto:
example 1 Water barrier coated capsules
Putting 8g of methyl stearate, 4g of beeswax and 4g of palmitic acid into a round-bottom flask, melting and mixing in a water bath kettle at 80 ℃, uniformly stirring, adding 6ml of n-hexane, heating and refluxing for 30 minutes, and uniformly stirring to obtain the edible waterproof coating solution.
Respectively taking 5 gelatin hollow capsules (batch number: 20220220210) and 5 enteric gelatin hollow capsules (batch number: 20220220220220220211), respectively opening capsule caps, adding 5-6 drops of water-proof coating solution into each capsule shell while the solution is hot, covering the capsule caps, quickly shaking to uniformly coat the solution on the inner walls of the capsules, standing at room temperature, after the coating is fixed and formed, opening the coated capsules, and drying at 25 ℃ for 20 minutes to obtain the gelatin hollow capsules (marked as S1) with edible water-proof coatings coated on the inner walls and the enteric gelatin hollow capsules (marked as S2) with edible water-proof coatings coated on the inner walls, wherein the thicknesses of the coatings are 0.4-0.5mm. The obtained edible waterproof coating has the characteristics of antibiosis, difficult damage, no toxicity and no harm.
Comparative example 1 capsules coated with different proportions
In the same manner as in example 1, one or more of methyl stearate, beeswax and palmitic acid were mixed in different proportions and placed in a round bottom flask according to the method shown in Table 1 and 2, and the mixture was melted and mixed in a water bath at 80 ℃ and stirred uniformly, heated for 30 minutes and stirred uniformly to obtain a coating solution.
Respectively taking 5 capsules of gelatin hollow capsules (batch number: 20220210) and 5 capsules of enteric gelatin hollow capsules (batch number: 20220220220220211), respectively opening capsule caps, respectively adding 5-6 drops of coating solutions with different proportions into each capsule shell while the capsules are hot, covering the capsule caps, quickly shaking to uniformly coat the solution on the inner wall of the capsules, standing at room temperature, fixing and forming the coatings, opening the coated capsules, and drying at 25 ℃ for 20 minutes to obtain the capsules with different proportions, wherein the serial numbers are shown in tables 1 and 2.
TABLE 1 coating capsule number (gelatin hollow capsule) with different proportions
| Stearic acid methyl ester | Beeswax (Cera flava) | Palmitic acid | N-hexane | Numbering |
| 8g | 0 | 0 | 6ml | A1 |
| 0 | 4g | 0 | 6ml | A2 |
| 0 | 0 | 4g | 6ml | A3 |
| 8g | 4g | 0 | 6ml | A4 |
| 8g | 0 | 4g | 6ml | A5 |
| 0 | 4g | 4g | 6ml | A6 |
| 4g | 4g | 4g | 6ml | A7 |
| 4g | 4g | 8g | 6ml | A8 |
| 4g | 8g | 4g | 6ml | A9 |
| 10g | 1g | 1g | 6ml | A10 |
| 8g | 4g | 4g | 0 | A11 |
TABLE 2 coating capsule number of different proportions (enteric gelatin hollow capsule)
Comparative example 2 capsules coated with different materials
In the same manner as in example 1, according to tables 3 and 4, triglyceride and ethyl acetate were respectively used instead of methyl stearate, and then mixed with beeswax and palmitic acid, and put into a round bottom flask, and the mixture was melted and mixed in a water bath at 80 ℃, stirred uniformly, heated under reflux for 30 minutes, and stirred uniformly to obtain a coating solution.
Respectively taking 5 capsules of gelatin hollow capsules (batch number: 20220210) and 5 capsules of enteric gelatin hollow capsules (batch number: 20220220220220211), respectively opening capsule caps, respectively adding 5-6 drops of coating solutions of different materials into each capsule shell while the coating solutions are hot, covering the capsule caps, quickly shaking to uniformly coat the solution on the inner wall of the capsule, standing at room temperature, fixing and forming the coating, opening the coated capsules, and drying at 25 ℃ for 20 minutes to obtain the capsules with different material coatings, wherein the serial numbers are shown in tables 3 and 4.
TABLE 3 coating capsule number of different materials (gelatin hollow capsule)
| Triglycerides | Ethyl acetate | Beeswax (Cera flava) | Palmitic acid | N-hexane | Numbering |
| 8g | 0g | 4g | 4g | 6ml | C1 |
| 0g | 8g | 4g | 4g | 6ml | C2 |
TABLE 4 coating capsule number of different materials (enteric gelatin hollow capsule)
| Triglycerides | Ethyl acetate | Beeswax (Cera flava) | Palmitic acid | N-hexane | Numbering |
| 8g | 0g | 4g | 4g | 6ml | D1 |
| 0g | 8g | 4g | 4g | 6ml | D2 |
Example 2 coating Performance testing
The hollow capsules S1 and S2 coated with the waterproof coating on the inner wall prepared in example 1, the coating capsules A1 to A11 and B1 to B11 prepared in comparative example 1 and the coating capsules C1, C2, D1 and D2 prepared in comparative example 2 and made of different materials are respectively taken for 5 capsules, 0.5ml of purified water is respectively added into each capsule, and the capsules are placed at room temperature, and the properties are shown in tables 5 and 6. As can be seen from tables 5 and 6, the lower the palmitic acid content, the more easily the coating is broken, and the higher the palmitic acid content, the more easily the coating is crystallized, so that the coating is not filmed, therefore, a certain amount of palmitic acid can improve the stability of the coating; beeswax is a main film forming material and has strong hydrophobic effect, high hardness and poor plasticity, and the beeswax does not form a film when being used alone. The lower the content of methyl stearate, the higher the hardness of the coating, and the higher the content, the softer the coating, so that the methyl stearate plays a certain role of an emulsifier, n-hexane can soften and fuse the three, the viscosity of the coating can be improved, the coating is easy to volatilize and remove, and one of the four raw materials is not necessary.
TABLE 5 coating Performance test results (gelatin hollow capsules)
TABLE 6 coating Performance test results (enteric gelatin hollow capsules)
Example 3 experiment for improving stability of Chinese patent medicine capsules
Because the traditional Chinese medicine components have strong moisture absorption characteristics, the traditional Chinese medicine capsule shell is reduced in stability after being placed for a long time and is fragile and fragile, and the problem can be effectively solved by adopting the waterproof coating. The Chinese patent medicine capsule stability test is carried out on the gelatin hollow capsule (batch No. 20220210) and the enteric gelatin hollow capsule (batch No. 20220220220211), and the specific method is as follows:
comparison group: loading gelatin hollow capsule (batch No. 20220220210) and enteric gelatin hollow capsule (batch No. 20220220211) without water-proof coating into rhizoma Gastrodiae refreshing Chinese medicinal components.
Test article group: the gastrodia elata refreshment traditional Chinese medicine ingredients are filled into the gelatin hollow capsule (batch number: 20220220210) S1 coated with the edible water-proof coating on the inner wall and the enteric gelatin hollow capsule (batch number: 20220220211) S2 coated with the edible water-proof coating on the inner wall, which are prepared by the method in the example 1.
The test is carried out according to friability inspection method under the item of a hollow gelatin capsule 2020 < Chinese pharmacopoeia >, 50 granules of a test sample group and a comparison group are respectively taken and placed in a watch glass, the watch glass is placed in a dryer filled with saturated solution of magnesium nitrate, the temperature is kept at 25 +/-1 ℃ for 24 hours, the test sample group and the comparison group are taken out, the test sample group and the comparison group are immediately placed in a glass tube (the inner diameter is 24mm, the length is 200 mm) which is erected on a wood board (the thickness is 2 cm) one by one, and a cylindrical code (the material is polytetrafluoroethylene, the diameter is 22mm, and the weight is 20g +/-0.1 g) is freely dropped from the opening of the glass tube. The results are shown in table 7 and table 8, which indicate that the waterproof coating can effectively reduce the brittleness of the capsule caused by the moisture absorption of the Chinese patent medicine and improve the stability of the Chinese patent medicine capsule.
TABLE 7 stability test results for Chinese medicinal capsule (gelatin hollow capsule)
| Time (moon) | 1 | 2 | 3 | 4 | 6 |
| Comparative group crisp number (particle) | 0 | 1 | 5 | 12 | 19 |
| Test article set (S1) number of brittle pieces (grains) | 0 | 0 | 0 | 3 | 3 |
TABLE 8 stability test results of Chinese patent medicine capsules (enteric gelatin hollow capsules)
| Time (moon) | 1 | 2 | 3 | 4 | 6 |
| Comparative group crisp number (particle) | 0 | 0 | 0 | 4 | 7 |
| Test article group (S2) number of brittle pieces (grains) | 0 | 0 | 0 | 0 | 1 |
Example 4 disintegration test of capsules
The disintegration time limit test was carried out on gelatin empty capsules (batch No. 20220210) and enteric gelatin empty capsules (batch No. 20220220220211) by the following specific methods:
comparison group: gelatin empty capsules without water-barrier coating (batch No. 20220210), enteric gelatin empty capsules (batch No. 20220220211).
Test article group: gelatin hollow capsules (lot: 20220210) S1 coated with edible water-barrier coating on the inner wall and enteric gelatin hollow capsules (lot: 20220211) S2 coated with edible water-barrier coating on the inner wall, which were prepared by the method of example 1.
The test is carried out according to 0921 disintegration time limit inspection method of the four ministry of general rules of the year 2020 edition of Chinese pharmacopoeia. 6 samples are taken and respectively placed in glass tubes of lifting disintegration tester hanging baskets, and a disintegration tester is started for inspection simultaneously for a sample group and a comparison group. The results of the disintegration time measurement are shown in Table 9.
TABLE 9 determination of disintegration time
The comparison group and the test sample group of the two hollow capsules are disintegrated within the specified range, the quality standard limit in pharmacopoeia is met, the disintegration time limit of the comparison group and the test sample group of the two hollow capsules has no obvious difference, and the hollow capsule with the water-proof coating added on the inner wall surface has good disintegration.
Example 5 accelerated stability test
Accelerated stability tests were carried out on gelatin hollow capsules (lot # 20220210) S1 coated with an edible water-barrier coating on the inner wall and enteric gelatin hollow capsules (lot # 20220211) S2 coated with an edible water-barrier coating on the inner wall, which were prepared by the method of example 1.
Referring to accelerated stability test conditions specified in the guidelines of the stability test of 9001 raw material medicaments and preparations in the four ministry of the 2020 edition of Chinese pharmacopoeia, the capsule medicament coated with the waterproof coating is sensitive to temperature because the main raw material of the waterproof coating is a low-melting-point substance, and the accelerated test of the medicinal preparation can be carried out under the conditions of the temperature of 25 +/-2 ℃ and the relative humidity of 60 +/-5 percent at the temperature of 5 +/-3 ℃ in a refrigerator.
30 particles of S1 and S2 coated with a water-proof coating are respectively taken, 0.5ml of pure water is filled in the capsule, and the capsule is placed under the conditions of the temperature of 25 ℃ plus or minus 2 ℃ and the relative humidity of 60 percent plus or minus 5 percent. 10 capsules were taken out at 0, 3 and 6 month points, and the quality standards of the four gelatin empty capsules were referred to "Chinese pharmacopoeia" 2020 edition, and the quality change of the properties and the content water content and the disintegration time limit items were examined and measured, and the results are shown in Table 10.
TABLE 10 accelerated stability test results
The results show that after the water-proof coating-coated capsule is placed in water, the properties, the water quality and the disintegration time are not obviously changed, which indicates that the acceleration stability is good.
The foregoing is illustrative of the preferred embodiments of this invention, and it is to be understood that the invention is not limited to the precise form disclosed herein and that various other combinations, modifications, and environments may be resorted to, falling within the scope of the concept as disclosed herein, either as described above or as apparent to those skilled in the relevant art. And that modifications and variations may be effected by those skilled in the art without departing from the spirit and scope of the invention as defined by the appended claims.
Claims (9)
1. The water-resisting coating solution for the inner wall of the capsule is characterized by being prepared from beeswax, palmitic acid, methyl stearate and n-hexane.
2. The water-barrier coating solution of claim 1, wherein the mass ratio of beeswax, palmitic acid and methyl stearate is 1; the volume dosage of the n-hexane is 0.5-5ml/g calculated by the mass of the beeswax.
3. The water-barrier coating solution according to claim 1 or 2, wherein the mass ratio of beeswax, palmitic acid and methyl stearate is 1; the volume usage of the n-hexane is 1.5ml/g calculated by the mass of the beeswax.
4. The water-barrier coating solution of claim 1, prepared by the following method: heating and mixing the beeswax, the palmitic acid and the methyl stearate, and uniformly stirring until the beeswax, the palmitic acid and the methyl stearate are completely melted and mixed; and adding n-hexane, refluxing, heating and uniformly mixing to obtain a water-proof coating solution.
5. The water-barrier coating solution of claim 4, wherein the beeswax, palmitic acid and methyl stearate are melted and mixed by heating to 80 ℃.
6. The water-barrier coating solution of claim 4, wherein the reflux time after the n-hexane addition is 30min.
7. The use of the water-barrier coating solution of claim 1 for preparing water-barrier capsules, which is prepared by the following steps: and (3) coating the water-resisting coating solution in the hollow capsule, standing for solidification, and drying to obtain the capsule coated with the water-resisting coating.
8. The use according to claim 7, wherein the water-barrier coating solution is added dropwise to the empty capsules; the dripping is to open the hollow capsule cap, drip 5-6 drops of water-proof coating solution, buckle the capsule cap, turn over up and down to make the solution evenly spread on the inner wall of the capsule, stand, wait for the coating to fix and shape; and uniformly coating the solution on the inner wall of the capsule, covering a capsule cap, standing at room temperature, and fixing and molding the coating.
9. Use according to claim 8, wherein the drying is carried out by opening the applied capsules and drying them at 25 ℃ for 20 minutes.
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