CN1158076C - Thrombolytic injection for curing cerebral infarction or cerebral thrombus - Google Patents
Thrombolytic injection for curing cerebral infarction or cerebral thrombus Download PDFInfo
- Publication number
- CN1158076C CN1158076C CNB011188111A CN01118811A CN1158076C CN 1158076 C CN1158076 C CN 1158076C CN B011188111 A CNB011188111 A CN B011188111A CN 01118811 A CN01118811 A CN 01118811A CN 1158076 C CN1158076 C CN 1158076C
- Authority
- CN
- China
- Prior art keywords
- vinegar
- acetic acid
- injection
- cerebral
- methyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 208000026106 cerebrovascular disease Diseases 0.000 title claims abstract description 40
- 238000002347 injection Methods 0.000 title claims abstract description 34
- 239000007924 injection Substances 0.000 title claims abstract description 34
- 206010008118 cerebral infarction Diseases 0.000 title claims abstract description 32
- 201000001429 Intracranial Thrombosis Diseases 0.000 title claims abstract description 31
- 230000002537 thrombolytic effect Effects 0.000 title claims abstract description 23
- 239000003146 anticoagulant agent Substances 0.000 title claims abstract description 21
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 claims abstract description 90
- 206010008132 Cerebral thrombosis Diseases 0.000 claims abstract description 29
- 239000000052 vinegar Substances 0.000 claims description 26
- 235000021419 vinegar Nutrition 0.000 claims description 26
- JTILNPRVUGXTAG-UHFFFAOYSA-N CN1C=CC=CC1C=NO.I Chemical compound CN1C=CC=CC1C=NO.I JTILNPRVUGXTAG-UHFFFAOYSA-N 0.000 claims description 15
- 241000209094 Oryza Species 0.000 claims description 8
- 235000007164 Oryza sativa Nutrition 0.000 claims description 8
- 238000004821 distillation Methods 0.000 claims description 8
- 235000009566 rice Nutrition 0.000 claims description 8
- 239000007788 liquid Substances 0.000 claims description 7
- 239000000243 solution Substances 0.000 claims description 6
- 239000005419 vinegar essence Substances 0.000 claims description 6
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 6
- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 claims description 5
- 125000003118 aryl group Chemical group 0.000 claims description 5
- 238000004519 manufacturing process Methods 0.000 claims description 5
- 238000000034 method Methods 0.000 claims description 2
- 230000000694 effects Effects 0.000 abstract description 16
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- 208000024172 Cardiovascular disease Diseases 0.000 abstract description 9
- 229940090044 injection Drugs 0.000 description 22
- 230000002526 effect on cardiovascular system Effects 0.000 description 9
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- OIPILFWXSMYKGL-UHFFFAOYSA-N acetylcholine Chemical compound CC(=O)OCC[N+](C)(C)C OIPILFWXSMYKGL-UHFFFAOYSA-N 0.000 description 4
- 229960004373 acetylcholine Drugs 0.000 description 4
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 4
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- 230000000302 ischemic effect Effects 0.000 description 3
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- -1 1-methyl-2-pyridine carboxaldehyde oxime iodide acetic acid Chemical compound 0.000 description 2
- 208000001889 Acid-Base Imbalance Diseases 0.000 description 2
- 201000006474 Brain Ischemia Diseases 0.000 description 2
- 206010008120 Cerebral ischaemia Diseases 0.000 description 2
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- OEYIOHPDSNJKLS-UHFFFAOYSA-N choline Chemical compound C[N+](C)(C)CCO OEYIOHPDSNJKLS-UHFFFAOYSA-N 0.000 description 2
- 229960001231 choline Drugs 0.000 description 2
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- SIJQAHHDPKVMGR-UHFFFAOYSA-N CC1=CC=CN=C1C=NO.I Chemical compound CC1=CC=CN=C1C=NO.I SIJQAHHDPKVMGR-UHFFFAOYSA-N 0.000 description 1
- 206010008190 Cerebrovascular accident Diseases 0.000 description 1
- 208000019505 Deglutition disease Diseases 0.000 description 1
- 229920002307 Dextran Polymers 0.000 description 1
- 208000005189 Embolism Diseases 0.000 description 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Chemical compound OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
- 206010062713 Haemorrhagic diathesis Diseases 0.000 description 1
- 206010021143 Hypoxia Diseases 0.000 description 1
- 206010028851 Necrosis Diseases 0.000 description 1
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- 206010067482 No adverse event Diseases 0.000 description 1
- 235000003143 Panax notoginseng Nutrition 0.000 description 1
- 241000180649 Panax notoginseng Species 0.000 description 1
- 208000034189 Sclerosis Diseases 0.000 description 1
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 1
- 208000006011 Stroke Diseases 0.000 description 1
- 230000001154 acute effect Effects 0.000 description 1
- 210000000577 adipose tissue Anatomy 0.000 description 1
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- 230000007953 anoxia Effects 0.000 description 1
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- 210000005013 brain tissue Anatomy 0.000 description 1
- 201000011510 cancer Diseases 0.000 description 1
- 230000000747 cardiac effect Effects 0.000 description 1
- 230000002490 cerebral effect Effects 0.000 description 1
- 208000029078 coronary artery disease Diseases 0.000 description 1
- 230000018109 developmental process Effects 0.000 description 1
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- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 208000035475 disorder Diseases 0.000 description 1
- OVXQHPWHMXOFRD-UHFFFAOYSA-M ecothiopate iodide Chemical compound [I-].CCOP(=O)(OCC)SCC[N+](C)(C)C OVXQHPWHMXOFRD-UHFFFAOYSA-M 0.000 description 1
- 230000002124 endocrine Effects 0.000 description 1
- 238000003912 environmental pollution Methods 0.000 description 1
- 239000000284 extract Substances 0.000 description 1
- 229940093181 glucose injection Drugs 0.000 description 1
- 210000005003 heart tissue Anatomy 0.000 description 1
- 208000031169 hemorrhagic disease Diseases 0.000 description 1
- XMBWDFGMSWQBCA-UHFFFAOYSA-N hydrogen iodide Chemical compound I XMBWDFGMSWQBCA-UHFFFAOYSA-N 0.000 description 1
- 238000010253 intravenous injection Methods 0.000 description 1
- 210000003141 lower extremity Anatomy 0.000 description 1
- 206010025482 malaise Diseases 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 230000017074 necrotic cell death Effects 0.000 description 1
- 231100000957 no side effect Toxicity 0.000 description 1
- 239000003182 parenteral nutrition solution Substances 0.000 description 1
- 230000035790 physiological processes and functions Effects 0.000 description 1
- 201000002241 progressive bulbar palsy Diseases 0.000 description 1
- 230000005180 public health Effects 0.000 description 1
- 235000019633 pungent taste Nutrition 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 230000009711 regulatory function Effects 0.000 description 1
- 230000003716 rejuvenation Effects 0.000 description 1
- 230000035807 sensation Effects 0.000 description 1
- 235000019615 sensations Nutrition 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 210000001364 upper extremity Anatomy 0.000 description 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
Description
Embodiment | 1 | 2 | 3 | 4 | 5 | 6 |
1-methyl-2 pyridine carboxaldehyde oxime iodide (gram) | 5 | 15 | 40 | 50 | 60 | 30 |
Acetic acid (gram) | 1 | 2 | 6 | 12 | 9 | 5 (vinegar essence) |
Claims (5)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CNB011188111A CN1158076C (en) | 2001-06-14 | 2001-06-14 | Thrombolytic injection for curing cerebral infarction or cerebral thrombus |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CNB011188111A CN1158076C (en) | 2001-06-14 | 2001-06-14 | Thrombolytic injection for curing cerebral infarction or cerebral thrombus |
Publications (2)
Publication Number | Publication Date |
---|---|
CN1326734A CN1326734A (en) | 2001-12-19 |
CN1158076C true CN1158076C (en) | 2004-07-21 |
Family
ID=4663448
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CNB011188111A Expired - Fee Related CN1158076C (en) | 2001-06-14 | 2001-06-14 | Thrombolytic injection for curing cerebral infarction or cerebral thrombus |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN1158076C (en) |
-
2001
- 2001-06-14 CN CNB011188111A patent/CN1158076C/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
CN1326734A (en) | 2001-12-19 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
C06 | Publication | ||
PB01 | Publication | ||
C14 | Grant of patent or utility model | ||
GR01 | Patent grant | ||
ASS | Succession or assignment of patent right |
Owner name: WANG LISHA; WANG LINUO Free format text: FORMER OWNER: WANG ZHIGUANG Effective date: 20060901 |
|
C41 | Transfer of patent application or patent right or utility model | ||
TR01 | Transfer of patent right |
Effective date of registration: 20060901 Address after: 072350 Tangxian County Hebei Seed Industry Co., Ltd. Co-patentee after: Wang Lina Patentee after: Wang Lisha Address before: 072350 people's Hospital of Xiangyang North Street, Tangxian County, Hebei Patentee before: Wang Zhiguang |
|
C19 | Lapse of patent right due to non-payment of the annual fee | ||
CF01 | Termination of patent right due to non-payment of annual fee |