A kind of treatment cerebral infarction or cerebral thrombosis thrombolytic injection
The present invention relates to a kind of treatment cerebral infarction or cerebral thrombosis thrombolytic injection.
As everyone knows, cerebral infarction, cerebral thrombosis, myocardial infarction are modal acute cardiovascular and cerebrovascular diseases, belong to ischemic cardio cerebrovascular diseases or occlusive cardiovascular and cerebrovascular disease, be commonly considered as the local heart and brain tissues ischemic necrosis and the sclerosis that cause owing to cerebral ischemia, the main cause that causes cerebral infarction, cerebral thrombosis, coronary heart disease, myocardial infarction is that tremulous pulse (blood vessel) is atherosis, but international medical community is also not fully aware of to atherosclerosis formation reason at present.In recent years, along with whole world aged tendency of population, aged's ratio in total population increases year by year, discloses according to the relevant person, and China has stepped into aging country.Along with people's living standard improves constantly, environmental pollution increasingly sharpens, and at present, the sickness rate of cardiovascular and cerebrovascular diseases such as cerebral infarction, cerebral thrombosis, myocardial infarction rises year by year, and constantly rejuvenation, cause one of three big killers that human and cancer, AIDS run neck and neck.
Old suffer from cardiovascular and cerebrovascular vessel blood supply insufficiency and heart and brain infraction be with old people's bodily tissue composition for example total body fat increases and physiological function for example whole body moisture content, cardiac flow decline are closely related, also be a kind of objective natural law.The medicine of multiple treatment cerebral infarction, cerebral thrombosis is arranged in the market, and therapeutic effect is undesirable, and cure rate is low, and side effect is arranged, and does not satisfy the needs of patients of suffering from cardiovascular and cerebrovascular disease, becomes a great problem of current medical circle treatment cardiovascular and cerebrovascular disease.For example XUESAITONG, MAILUONING cure rate are 7.5% only, and dry pharynx, giddy and untoward reaction such as nervous are arranged during the treatment.The arasaponin that extracts with the rare Chinese medicine Radix Notoginseng is 38% through the Fructus Liquidambaris injection of purification to cerebral thrombosis and cerebral blood supply insufficiency case therapeutic effect produce effects.And for example low molecular dextran treatment ischemic cerebrovascular people produce effects is 23%, and invalid is 28%.
The objective of the invention is to overcome present clinical use medicine weak point, be engaged in Drug therapy theoretical research and clinical practice for a long time through the inventor, finding to form atherosclerosis in surprise by various chemical examinations is that cholinesterase activity descends in the human body, cause acid base imbalance result in the human body, thereby provide a kind of instant effect, short treating period, cure rate height, non-relapse after healing, blood fat reducing obvious treatment cerebral infarction or cerebral thrombosis thrombolytic injection.
Treatment cerebral infarction provided by the invention or cerebral thrombosis thrombolytic injection comprise following component and weight ratio, contain water injection through being mixed into water white transparency, and its PH is 3.5,
1-methyl-2 pyridine carboxaldehyde oxime iodide (claiming Echothiopate Iodide again) 5-70, acetic acid 1-10.
Be preferably 1-methyl-2 pyridine carboxaldehyde oxime iodide 5-50, acetic acid is 2-8.
1-methyl-2 pyridine carboxaldehyde oxime iodide 10-40 more preferably, acetic acid is 5-8.
In treatment cerebral infarction provided by the invention or cerebral thrombosis thrombolytic injection; described 1-methyl-2 pyridine carboxaldehyde oxime iodide are commercially available prod (Huaihai Pharmaceuticla Factory, Shanghai's manufacturing); for example it is a kind of colourless or almost colourless clear liquid, as contain 0.5 gram 1-methyl-2-pyridine carboxaldehyde oxime iodide in the 20ml injection.
Described acetic acid is commercially available tablet vinegar, for example rice vinegar Beijing San Chang production and sales, Shanxi mature vinegar, white vinegar, aromatic vinegar or vinegar essence etc. are preferably that rice vinegar Beijing San Chang produces, above-mentioned vinegar source must be under sterilising conditions in general distillation equipment distillation to obtain pH value be that the transparent acetate solution of 3.0-5.0 uses, effect is better, for example above-mentioned transparent acetate solution is made the acetic acid injection that contains one of 0.045 gram usually, and according to the pH value of transparent acetate solution, promptly acidometer is calculated acetic acid content to its content usually.
The inventor be engaged in Drug therapy theoretical research and clinical practice for a long time and learn by chemical examination cardiovascular and cerebrovascular diseases such as cerebral infarction, cerebral thrombosis, myocardial infarction and human body artery atherosis between cause effect relation, atherosclerosis is that cholinesterase activity descends in the human body, the acetic acid and the choline that the acetylcholine esterase acetylcholine can not be decomposed discharge q.s, cause endocrine disturbance in the body, self regulatory function disorder, acid base imbalance, the lipoprotein of cholesterol, triglyceride, low-density and extra-low density is risen, cause hyperlipidemia, arteriosclerosis.
The injection that is mixed of a kind of 1-methyl provided by the invention-2-pyridine carboxaldehyde oxime iodide and acetic acid enters in the special blood of human body of human body, can improve the vigor of acetylcholine esterase, cholinesterase makes acetylcholine under the effect of water, decomposite acetic acid and choline, regulate acid-base balance, make the cholesterol that causes hyperlipidemia, triglyceride, the lipoprotein of low-density and extra-low density decomposes decline, the dissolving embolus, blood viscosity lowering, replenish acetic acid simultaneously and recover acid-base balance, thereby eliminate or alleviate atherosclerosis, effect a radical cure or alleviate cardiovascular and cerebrovascular diseases such as cerebral infarction or cerebral thrombosis.
The invention provides in treatment cerebral infarction or the cerebral thrombosis injection manufacture method, above-mentioned two components are mixed, be mixed and be not strict with, the vinegar that water soluble parenteral solution that 1-methyl 2-pyridine carboxaldehyde oxime iodide such as market are buied and market are buied obtains acetate solution (pH value is 3.0-5.0) is mixed into different content by the weight ratio of above-mentioned two kinds of components treatment cerebral infarction or cerebral thrombosis thrombolytic injection through distillation, be made generally in content for injection 20ml or 10ml that restrain as 0.5 gram 1-methyl-2-pyridine carboxaldehyde oxime iodide and 0.9 or 0.135 gram acetic acid etc. is mixed, will instil after the dilution among its adding 5% or 10% glucose injection 500ml or the 0.9% normal saline 500-1000ml during as intravenous injection.
The characteristics of treatment cerebral infarction provided by the invention or cerebral thrombosis injection are:
1, thrombolytic speed is fast, the thrombolytic time unrestricted (international thrombolytic medicine limits if having time, otherwise bleeding tendency is arranged, but thrombolytic in the international standard morbidity 4 hours, in China's standard 6 hours), without the other medicines therapist, whole or most of thrombolytic in 72 hours.
2, the treatment phase state of an illness is not to serious development (other medicines treatment cerebral infarction, cerebral thrombosis have period of expansion, are the progressivity cerebral thrombosis).
3, instant effect, short treating period (1-5 days was 1 course of treatment), cure rate is high by 70%, non-relapse after healing, blood fat reducing is (making blood fat reduce to normal level in 5 days) obviously.1-5 hour spiritual affected limb has obvious change after produce effects person's medication, and drowsiness person's Cerebral Infarction Patients appears in treatment, can regain consciousness in about 2 hours behind 60 of the per minute dropping liquids; Myodynamia recovery is rapid, and making muscular strength at 24 hours was that 0 level restoration is to the II-III level originally; With Ipsilateral temperature contrast person, return to about 2 hours and the same temperature of strong side; Bulbar paralysis recovered normal at 24 hours.
4, preparation is simple, and easy to use, adaptability is strong, has no side effect, and individual patient has the bitter taste sensation.
Treatment cerebral infarction provided by the invention or cerebral thrombosis injection are widely used in cardiovascular and cerebrovascular diseases such as treatment cerebral infarction, cerebral thrombosis, myocardial infarction.
The present invention further specifies the present invention with the following example, but protection scope of the present invention is not limited to embodiment.
Embodiment 1
With commercially available rice vinegar (Beijing San Chang production), in general distillator, distill to such an extent that pH value is that acetic acid clear solution 1 gram (referring to wherein acetic acid content) of 3.0-5.0 is mixed with commercially available 5 gram 1-methyl-2 pyridine carboxaldehyde oxime iodide injection (referring to wherein 1 methyl 2-pyridine carboxaldehyde oxime iodide content), obtain pH value and be the injection that is mixed of 1-methyl-2-pyridine carboxaldehyde oxime iodide acetic acid of 3.5, or above-mentioned injection is distributed into contains 0.5 gram 1-methyl-2 pyridine carboxaldehyde oxime iodide acetic acid injection.
Embodiment 2-6
The preparation process of embodiment 2-6 is same as the step of embodiment, and different is that 1-methyl-2-pyridine carboxaldehyde oxime iodide and acetic acid consumption are shown in the table.
Table 1
Embodiment | 1 | 2 | 3 | 4 | 5 | 6 |
1-methyl-2 pyridine carboxaldehyde oxime iodide (gram) | 5 | 15 | 40 | 50 | 60 | 30 |
Acetic acid (gram) | 1 | 2 | 6 | 12 | 9 | 5 (vinegar essence) |
The clinical observation result of treatment cerebral infarction provided by the invention or cerebral thrombosis thrombolytic injection curative effect of medication is as follows:
Adopt the present invention to treat cerebral infarction or 40 cerebral infarction of cerebral thrombosis thrombolytic injection treatment or cerebral thrombus patient's clinical observation result from the People's Hospital, Tangxian County, February 9 to calendar year 2001 in 1994 9 Nikkei Hebei province in April and list in table 1
Table 1
Handle by statistics by table 1 data and to draw effective percentage 95% in 40 cases, cure rate 70%.
The efficacy assessment standard of medicine of the present invention in the table 1 (treating the clinical research guideline with reference to the apoplexy that Ministry of Public Health is formulated) is as follows:
(1) take effect:
Three days drowsiness sxs of intravenously administrable, sanity.
(2) effective:
The affected limb muscular strength returns to the I level from zero level, and temperature difference has obvious change.
(3) produce effects:
Three days patients of administration cure, 1-5 hour drowsiness sx, sanity after the medication, and (cerebral ischemia, anoxia have obvious change) affected limb has hotness, little painful sensation.
(4) cure:
Ipsilateral limbs muscular strength up and down returns to normally from zero level.(with sick preceding identical) do not influence physical work or language has the person of not knowing slightly.
(5) invalid:
Medication three days, drowsiness, mind, spirit, swallow, language, gatism, upper and lower extremities muscular strength and temperature difference do not have the changer for invalid.
(6) sequela:
The basic self-care of living maybe can not be taken care of oneself, and can not participate in slight physical work or heavy physical labour.Aphasis, dysphagia, gatism.
List in table 2 through the People's Hospital, Tangxian County, Hebei province with the therapeutic effect that treatment cerebral infarction provided by the invention or cerebral thrombosis thrombolytic injection are treated 26 cases through 3-40 days nonresponders of other hospitalize
Table 2
In 26 cases, male 20 people, women 6 people, 58.89 years old mean age.On average everyone treated natural law 5.92 days, and effective percentage is 92.31%.Cure rate 57.6% ± 091.
Matched group uses XUESAITONG, MAILUONING that the efficacy result of 40 treatment cerebral infarction, cerebral thrombosis is listed in table 3 through the People's Hospital, Tangxian County, Hebei province
Table 3
Two groups of data are compared analysis:
Medication therapy groups of the present invention:
Treatment is organized in 40 cases, male's 29 examples, and women's 11 examples, 56.5 years old mean age, mean treatment natural law 5.6 days, small number of patients has the bitter taste sensation during the treatment, recovers after the drug withdrawal, and effective percentage is 95%, cure rate 70%.
Matched group: in 40 cases, male's 27 examples, women's 13 examples, 66.525 years old mean age, mean treatment natural law 8.975 days, untoward reaction during the treatment, dry pharynx, giddy and nervous recover effective percentage 65%, cure rate 7.5% after the drug withdrawal.
This shows that the cure rate of treatment group, effective percentage exceed 30 and 62.5 percentage points of matched group respectively, and have no adverse reaction.