CN115804823A - Traditional Chinese medicine composition for treating cervical precancerous lesions - Google Patents
Traditional Chinese medicine composition for treating cervical precancerous lesions Download PDFInfo
- Publication number
- CN115804823A CN115804823A CN202211664438.0A CN202211664438A CN115804823A CN 115804823 A CN115804823 A CN 115804823A CN 202211664438 A CN202211664438 A CN 202211664438A CN 115804823 A CN115804823 A CN 115804823A
- Authority
- CN
- China
- Prior art keywords
- parts
- traditional chinese
- chinese medicine
- treating cervical
- medicine composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000203 mixture Substances 0.000 title claims abstract description 54
- 239000003814 drug Substances 0.000 title claims abstract description 51
- 230000003902 lesion Effects 0.000 title claims abstract description 41
- 206010008342 Cervix carcinoma Diseases 0.000 claims abstract description 16
- 208000006105 Uterine Cervical Neoplasms Diseases 0.000 claims abstract description 16
- 201000010881 cervical cancer Diseases 0.000 claims abstract description 16
- 244000303040 Glycyrrhiza glabra Species 0.000 claims abstract description 12
- 235000006200 Glycyrrhiza glabra Nutrition 0.000 claims abstract description 12
- 239000009136 dragon's blood Substances 0.000 claims abstract description 12
- 239000004863 Frankincense Substances 0.000 claims abstract description 10
- 235000003717 Boswellia sacra Nutrition 0.000 claims abstract description 9
- 240000007551 Boswellia serrata Species 0.000 claims abstract description 9
- 235000012035 Boswellia serrata Nutrition 0.000 claims abstract description 9
- 240000007311 Commiphora myrrha Species 0.000 claims abstract description 9
- 235000006965 Commiphora myrrha Nutrition 0.000 claims abstract description 9
- 235000007265 Myrrhis odorata Nutrition 0.000 claims abstract description 9
- LPLVUJXQOOQHMX-QWBHMCJMSA-N glycyrrhizinic acid Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@H](O[C@@H]1O[C@@H]1C([C@H]2[C@]([C@@H]3[C@@]([C@@]4(CC[C@@]5(C)CC[C@@](C)(C[C@H]5C4=CC3=O)C(O)=O)C)(C)CC2)(C)CC1)(C)C)C(O)=O)[C@@H]1O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]1O LPLVUJXQOOQHMX-QWBHMCJMSA-N 0.000 claims abstract description 9
- 235000011477 liquorice Nutrition 0.000 claims abstract description 9
- 240000009022 Smilax rotundifolia Species 0.000 claims abstract description 8
- 235000003205 Smilax rotundifolia Nutrition 0.000 claims abstract description 8
- 240000004824 Trimezia steyermarkii Species 0.000 claims abstract description 5
- 240000002503 Vitis amurensis Species 0.000 claims abstract description 3
- 235000004283 Vitis amurensis Nutrition 0.000 claims abstract description 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 46
- 239000000284 extract Substances 0.000 claims description 23
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims description 19
- 238000002360 preparation method Methods 0.000 claims description 19
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 17
- 239000000463 material Substances 0.000 claims description 11
- 238000001035 drying Methods 0.000 claims description 10
- 239000011780 sodium chloride Substances 0.000 claims description 9
- 238000001914 filtration Methods 0.000 claims description 8
- 239000007788 liquid Substances 0.000 claims description 8
- CHHHXKFHOYLYRE-UHFFFAOYSA-M 2,4-Hexadienoic acid, potassium salt (1:1), (2E,4E)- Chemical compound [K+].CC=CC=CC([O-])=O CHHHXKFHOYLYRE-UHFFFAOYSA-M 0.000 claims description 7
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 claims description 7
- 229930006000 Sucrose Natural products 0.000 claims description 7
- 235000006533 astragalus Nutrition 0.000 claims description 7
- 238000000034 method Methods 0.000 claims description 7
- 239000004302 potassium sorbate Substances 0.000 claims description 7
- 229940069338 potassium sorbate Drugs 0.000 claims description 7
- 235000010241 potassium sorbate Nutrition 0.000 claims description 7
- 238000002791 soaking Methods 0.000 claims description 7
- 239000005720 sucrose Substances 0.000 claims description 7
- 238000004821 distillation Methods 0.000 claims description 6
- 238000002156 mixing Methods 0.000 claims description 5
- 239000002244 precipitate Substances 0.000 claims description 5
- 238000001556 precipitation Methods 0.000 claims description 5
- 238000010992 reflux Methods 0.000 claims description 5
- 239000002904 solvent Substances 0.000 claims description 5
- 238000001256 steam distillation Methods 0.000 claims description 5
- 230000001954 sterilising effect Effects 0.000 claims description 5
- 244000025254 Cannabis sativa Species 0.000 claims description 4
- 238000011049 filling Methods 0.000 claims description 4
- 235000015099 wheat brans Nutrition 0.000 claims description 4
- 241000045403 Astragalus propinquus Species 0.000 claims description 3
- 239000000706 filtrate Substances 0.000 claims description 2
- 238000000605 extraction Methods 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 244000067602 Chamaesyce hirta Species 0.000 claims 1
- 239000012141 concentrate Substances 0.000 claims 1
- 239000002243 precursor Substances 0.000 claims 1
- 230000000694 effects Effects 0.000 abstract description 26
- 229940079593 drug Drugs 0.000 abstract description 10
- 229960004316 cisplatin Drugs 0.000 abstract description 9
- DQLATGHUWYMOKM-UHFFFAOYSA-L cisplatin Chemical compound N[Pt](N)(Cl)Cl DQLATGHUWYMOKM-UHFFFAOYSA-L 0.000 abstract description 9
- 201000010099 disease Diseases 0.000 abstract description 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract description 4
- 241001668545 Pascopyrum Species 0.000 abstract 1
- 229940107666 astragalus root Drugs 0.000 abstract 1
- 230000001737 promoting effect Effects 0.000 description 13
- 239000000243 solution Substances 0.000 description 13
- 235000019441 ethanol Nutrition 0.000 description 11
- 208000002193 Pain Diseases 0.000 description 10
- 239000008280 blood Substances 0.000 description 9
- 210000004369 blood Anatomy 0.000 description 9
- 230000000052 comparative effect Effects 0.000 description 8
- 206010007247 Carbuncle Diseases 0.000 description 6
- 238000005469 granulation Methods 0.000 description 6
- 230000003179 granulation Effects 0.000 description 6
- 210000000952 spleen Anatomy 0.000 description 6
- 231100000331 toxic Toxicity 0.000 description 6
- 230000002588 toxic effect Effects 0.000 description 6
- 239000003053 toxin Substances 0.000 description 6
- 206010028980 Neoplasm Diseases 0.000 description 5
- 206010042674 Swelling Diseases 0.000 description 5
- 230000007812 deficiency Effects 0.000 description 5
- 230000005764 inhibitory process Effects 0.000 description 5
- 230000008961 swelling Effects 0.000 description 5
- 231100000765 toxin Toxicity 0.000 description 5
- 238000001291 vacuum drying Methods 0.000 description 5
- 241001061264 Astragalus Species 0.000 description 4
- 241000701806 Human papillomavirus Species 0.000 description 4
- 208000009608 Papillomavirus Infections Diseases 0.000 description 4
- 208000005392 Spasm Diseases 0.000 description 4
- 230000017531 blood circulation Effects 0.000 description 4
- 235000009508 confectionery Nutrition 0.000 description 4
- 208000014674 injury Diseases 0.000 description 4
- 230000007774 longterm Effects 0.000 description 4
- 229940100688 oral solution Drugs 0.000 description 4
- 230000002265 prevention Effects 0.000 description 4
- 210000002784 stomach Anatomy 0.000 description 4
- 210000004233 talus Anatomy 0.000 description 4
- 206010012735 Diarrhoea Diseases 0.000 description 3
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 description 3
- 235000017443 Hedysarum boreale Nutrition 0.000 description 3
- 235000007858 Hedysarum occidentale Nutrition 0.000 description 3
- 208000003251 Pruritus Diseases 0.000 description 3
- 244000068697 Vitis rotundifolia Species 0.000 description 3
- 235000006359 Vitis rotundifolia var rotundifolia Nutrition 0.000 description 3
- 206010003549 asthenia Diseases 0.000 description 3
- 230000009286 beneficial effect Effects 0.000 description 3
- 230000004663 cell proliferation Effects 0.000 description 3
- 230000006378 damage Effects 0.000 description 3
- 238000011161 development Methods 0.000 description 3
- 230000018109 developmental process Effects 0.000 description 3
- 230000006870 function Effects 0.000 description 3
- 239000001947 glycyrrhiza glabra rhizome/root Substances 0.000 description 3
- 210000002216 heart Anatomy 0.000 description 3
- 210000004185 liver Anatomy 0.000 description 3
- 210000004072 lung Anatomy 0.000 description 3
- 230000035755 proliferation Effects 0.000 description 3
- 208000024891 symptom Diseases 0.000 description 3
- 230000008736 traumatic injury Effects 0.000 description 3
- 229960005486 vaccine Drugs 0.000 description 3
- 238000005303 weighing Methods 0.000 description 3
- 208000006820 Arthralgia Diseases 0.000 description 2
- 206010007882 Cellulitis Diseases 0.000 description 2
- 206010011224 Cough Diseases 0.000 description 2
- 208000010201 Exanthema Diseases 0.000 description 2
- 208000032843 Hemorrhage Diseases 0.000 description 2
- 239000009636 Huang Qi Substances 0.000 description 2
- 206010062717 Increased upper airway secretion Diseases 0.000 description 2
- 206010023126 Jaundice Diseases 0.000 description 2
- 240000000982 Malva neglecta Species 0.000 description 2
- 235000000060 Malva neglecta Nutrition 0.000 description 2
- 235000006770 Malva sylvestris Nutrition 0.000 description 2
- 206010027514 Metrorrhagia Diseases 0.000 description 2
- 206010030113 Oedema Diseases 0.000 description 2
- 244000131316 Panax pseudoginseng Species 0.000 description 2
- 235000003181 Panax pseudoginseng Nutrition 0.000 description 2
- 208000025865 Ulcer Diseases 0.000 description 2
- 241000219095 Vitis Species 0.000 description 2
- 235000009754 Vitis X bourquina Nutrition 0.000 description 2
- 235000012333 Vitis X labruscana Nutrition 0.000 description 2
- 235000014787 Vitis vinifera Nutrition 0.000 description 2
- 210000001015 abdomen Anatomy 0.000 description 2
- 239000002246 antineoplastic agent Substances 0.000 description 2
- 229940041181 antineoplastic drug Drugs 0.000 description 2
- 230000000740 bleeding effect Effects 0.000 description 2
- 201000011510 cancer Diseases 0.000 description 2
- 230000010261 cell growth Effects 0.000 description 2
- 230000008859 change Effects 0.000 description 2
- 238000006243 chemical reaction Methods 0.000 description 2
- 230000004087 circulation Effects 0.000 description 2
- 238000002573 colposcopy Methods 0.000 description 2
- 238000001816 cooling Methods 0.000 description 2
- 238000012258 culturing Methods 0.000 description 2
- 238000001514 detection method Methods 0.000 description 2
- 206010012601 diabetes mellitus Diseases 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 201000005884 exanthem Diseases 0.000 description 2
- 210000003414 extremity Anatomy 0.000 description 2
- 230000036541 health Effects 0.000 description 2
- 208000015181 infectious disease Diseases 0.000 description 2
- 230000008595 infiltration Effects 0.000 description 2
- 238000001764 infiltration Methods 0.000 description 2
- 230000002401 inhibitory effect Effects 0.000 description 2
- 238000002347 injection Methods 0.000 description 2
- 239000007924 injection Substances 0.000 description 2
- 230000007803 itching Effects 0.000 description 2
- 238000002386 leaching Methods 0.000 description 2
- 230000036210 malignancy Effects 0.000 description 2
- 230000007935 neutral effect Effects 0.000 description 2
- 230000001717 pathogenic effect Effects 0.000 description 2
- 208000026435 phlegm Diseases 0.000 description 2
- 231100000614 poison Toxicity 0.000 description 2
- 239000013641 positive control Substances 0.000 description 2
- 206010037844 rash Diseases 0.000 description 2
- 230000001105 regulatory effect Effects 0.000 description 2
- 238000011160 research Methods 0.000 description 2
- 238000005728 strengthening Methods 0.000 description 2
- 210000002435 tendon Anatomy 0.000 description 2
- 239000003440 toxic substance Substances 0.000 description 2
- 231100000419 toxicity Toxicity 0.000 description 2
- 230000001988 toxicity Effects 0.000 description 2
- 231100000397 ulcer Toxicity 0.000 description 2
- 206010000077 Abdominal mass Diseases 0.000 description 1
- 206010063409 Acarodermatitis Diseases 0.000 description 1
- 241000727554 Ampelopsis cordata Species 0.000 description 1
- 241000255789 Bombyx mori Species 0.000 description 1
- 241000717739 Boswellia sacra Species 0.000 description 1
- 206010006187 Breast cancer Diseases 0.000 description 1
- 208000026310 Breast neoplasm Diseases 0.000 description 1
- 101150061050 CIN1 gene Proteins 0.000 description 1
- 208000009458 Carcinoma in Situ Diseases 0.000 description 1
- 241000258920 Chilopoda Species 0.000 description 1
- 241000721047 Danaus plexippus Species 0.000 description 1
- 208000030453 Drug-Related Side Effects and Adverse reaction Diseases 0.000 description 1
- 208000036119 Frailty Diseases 0.000 description 1
- 208000012671 Gastrointestinal haemorrhages Diseases 0.000 description 1
- 206010018367 Glomerulonephritis chronic Diseases 0.000 description 1
- 102000014150 Interferons Human genes 0.000 description 1
- 108010050904 Interferons Proteins 0.000 description 1
- 206010061245 Internal injury Diseases 0.000 description 1
- 208000008763 Mercury poisoning Diseases 0.000 description 1
- 206010027439 Metal poisoning Diseases 0.000 description 1
- 208000000112 Myalgia Diseases 0.000 description 1
- 241001057584 Myrrha Species 0.000 description 1
- 208000001140 Night Blindness Diseases 0.000 description 1
- 241001248610 Ophiocordyceps sinensis Species 0.000 description 1
- 206010033557 Palpitations Diseases 0.000 description 1
- 206010033799 Paralysis Diseases 0.000 description 1
- 206010038084 Rectocele Diseases 0.000 description 1
- 208000025747 Rheumatic disease Diseases 0.000 description 1
- 241000304195 Salvia miltiorrhiza Species 0.000 description 1
- 235000011135 Salvia miltiorrhiza Nutrition 0.000 description 1
- 241000447727 Scabies Species 0.000 description 1
- 206010040943 Skin Ulcer Diseases 0.000 description 1
- 241001404789 Smilax glabra Species 0.000 description 1
- 241000246044 Sophora flavescens Species 0.000 description 1
- 208000033809 Suppuration Diseases 0.000 description 1
- 208000002474 Tinea Diseases 0.000 description 1
- 241000130764 Tinea Species 0.000 description 1
- 206010070863 Toxicity to various agents Diseases 0.000 description 1
- 208000006374 Uterine Cervicitis Diseases 0.000 description 1
- 206010046788 Uterine haemorrhage Diseases 0.000 description 1
- 206010046910 Vaginal haemorrhage Diseases 0.000 description 1
- 235000007212 Verbena X moechina Moldenke Nutrition 0.000 description 1
- 240000001519 Verbena officinalis Species 0.000 description 1
- 235000001594 Verbena polystachya Kunth Nutrition 0.000 description 1
- 235000007200 Verbena x perriana Moldenke Nutrition 0.000 description 1
- 235000002270 Verbena x stuprosa Moldenke Nutrition 0.000 description 1
- 241000219094 Vitaceae Species 0.000 description 1
- 208000019790 abdominal distention Diseases 0.000 description 1
- 230000003187 abdominal effect Effects 0.000 description 1
- 230000002159 abnormal effect Effects 0.000 description 1
- 238000002835 absorbance Methods 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 238000009825 accumulation Methods 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 239000002671 adjuvant Substances 0.000 description 1
- 229930013930 alkaloid Natural products 0.000 description 1
- 150000003797 alkaloid derivatives Chemical class 0.000 description 1
- 230000003698 anagen phase Effects 0.000 description 1
- 208000022531 anorexia Diseases 0.000 description 1
- 235000019606 astringent taste Nutrition 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- 238000001574 biopsy Methods 0.000 description 1
- 239000002775 capsule Substances 0.000 description 1
- 238000001516 cell proliferation assay Methods 0.000 description 1
- 239000006285 cell suspension Substances 0.000 description 1
- 208000019065 cervical carcinoma Diseases 0.000 description 1
- 206010008323 cervicitis Diseases 0.000 description 1
- 210000000038 chest Anatomy 0.000 description 1
- 208000019902 chronic diarrheal disease Diseases 0.000 description 1
- 230000001684 chronic effect Effects 0.000 description 1
- 101150005988 cin2 gene Proteins 0.000 description 1
- 238000010924 continuous production Methods 0.000 description 1
- 239000013078 crystal Substances 0.000 description 1
- 238000005520 cutting process Methods 0.000 description 1
- 238000002784 cytotoxicity assay Methods 0.000 description 1
- 231100000263 cytotoxicity test Toxicity 0.000 description 1
- 206010061428 decreased appetite Diseases 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 230000000857 drug effect Effects 0.000 description 1
- 208000001848 dysentery Diseases 0.000 description 1
- 206010013990 dysuria Diseases 0.000 description 1
- 230000004438 eyesight Effects 0.000 description 1
- 239000008187 granular material Substances 0.000 description 1
- 235000021021 grapes Nutrition 0.000 description 1
- 238000009499 grossing Methods 0.000 description 1
- 230000035876 healing Effects 0.000 description 1
- 208000035861 hematochezia Diseases 0.000 description 1
- 235000008216 herbs Nutrition 0.000 description 1
- 238000009396 hybridization Methods 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 229940079322 interferon Drugs 0.000 description 1
- 210000003734 kidney Anatomy 0.000 description 1
- 201000007227 lymph node tuberculosis Diseases 0.000 description 1
- 230000003211 malignant effect Effects 0.000 description 1
- 235000012054 meals Nutrition 0.000 description 1
- 230000027939 micturition Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 210000003205 muscle Anatomy 0.000 description 1
- 201000009240 nasopharyngitis Diseases 0.000 description 1
- 230000001338 necrotic effect Effects 0.000 description 1
- 235000015097 nutrients Nutrition 0.000 description 1
- 235000016709 nutrition Nutrition 0.000 description 1
- 230000035764 nutrition Effects 0.000 description 1
- 239000002674 ointment Substances 0.000 description 1
- 244000045947 parasite Species 0.000 description 1
- 244000052769 pathogen Species 0.000 description 1
- 230000008506 pathogenesis Effects 0.000 description 1
- 238000010827 pathological analysis Methods 0.000 description 1
- 230000001575 pathological effect Effects 0.000 description 1
- 150000007965 phenolic acids Chemical class 0.000 description 1
- 239000006187 pill Substances 0.000 description 1
- BASFCYQUMIYNBI-UHFFFAOYSA-N platinum Chemical group [Pt] BASFCYQUMIYNBI-UHFFFAOYSA-N 0.000 description 1
- 229920001184 polypeptide Polymers 0.000 description 1
- 102000004196 processed proteins & peptides Human genes 0.000 description 1
- 108090000765 processed proteins & peptides Proteins 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 238000004393 prognosis Methods 0.000 description 1
- 229940021993 prophylactic vaccine Drugs 0.000 description 1
- 201000001474 proteinuria Diseases 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 230000002040 relaxant effect Effects 0.000 description 1
- 230000000552 rheumatic effect Effects 0.000 description 1
- 239000009286 sanguis draxonis Substances 0.000 description 1
- 208000005687 scabies Diseases 0.000 description 1
- 238000012216 screening Methods 0.000 description 1
- 230000035945 sensitivity Effects 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 239000004017 serum-free culture medium Substances 0.000 description 1
- 230000001568 sexual effect Effects 0.000 description 1
- 231100000019 skin ulcer Toxicity 0.000 description 1
- 230000002269 spontaneous effect Effects 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 239000006228 supernatant Substances 0.000 description 1
- 238000001356 surgical procedure Methods 0.000 description 1
- 230000004083 survival effect Effects 0.000 description 1
- 230000002195 synergetic effect Effects 0.000 description 1
- 208000006379 syphilis Diseases 0.000 description 1
- 239000003826 tablet Substances 0.000 description 1
- 235000019640 taste Nutrition 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 201000004647 tinea pedis Diseases 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 230000017423 tissue regeneration Effects 0.000 description 1
- 230000008733 trauma Effects 0.000 description 1
- 210000004291 uterus Anatomy 0.000 description 1
- 238000010200 validation analysis Methods 0.000 description 1
Abstract
The invention relates to the field of traditional Chinese medicine compositions, and in particular relates to a traditional Chinese medicine composition for treating cervical precancerous lesions. The composition comprises, by weight, 80-120 parts of glabrous greenbrier rhizome, 40-55 parts of common malted wheatgrass, 56-72 parts of amur grape, 19-37 parts of rhizoma polygoni multiflori, 55-75 parts of rhizoma atractylodis, 22-30 parts of nidus vespae, 60-70 parts of frankincense, 30-40 parts of myrrh, 42-58 parts of astragalus root, 22-33 parts of dragon's blood and 18-35 parts of liquorice. The medicines are matched with each other, can effectively treat the cervical cancer precancerous lesion, has the same treatment effect as cisplatin, and can effectively prevent the disease from continuously developing and developing into the cervical cancer.
Description
Technical Field
The invention relates to the field of traditional Chinese medicine compositions, and in particular relates to a traditional Chinese medicine composition for treating cervical precancerous lesions.
Background
Cervical cancer is one of the most common malignancies in women worldwide, second only to breast cancer, and is especially common in developing countries, first to various malignancies. The research on the occurrence and development of cervical cancer changes from quantitative change to qualitative change, and the occurrence and development of the cervical cancer is a continuous process of in-situ cancer, early stage infiltration cancer and infiltration cancer caused by the development of precancerous lesion, generally lasts for 5-10 years, if timely treatment can be found in the early stage, the prognosis of the cervical cancer is good, and the 5-year survival rate of patients in the Ia and Ib stages can reach 80% -100%, so that the prevention of the precancerous lesion has important clinical value for reducing the occurrence of the cervical cancer.
In recent years, three breakthrough advances have been made in the worldwide research on the prevention of cervical cancer: (1) Establishes that high-risk Human Papilloma Virus (HPV) infection is a necessary condition for the generation of cervical cancer; (2) The newly developed thin-layer liquid-based cytology and the new technology (the second generation hybridization capture test) for detecting the HPVDNA remarkably improve the sensitivity of identifying the cervical advanced lesion, greatly reduce the false negative, and can detect more than 98 percent of early patients by reasonably applying a screening method; (3) HPV prophylactic vaccines have been approved for clinical validation and are undergoing phase three clinical trials. The injection vaccine is a main prevention measure for cervical HPV infection in modern medicine, but the vaccine is still in shortage in most areas in China at present, and the vaccine is expensive in price, short in prevention period and needs to be injected repeatedly. For patients in the pre-cervical cancer lesion stage, the main treatment means is injection of antitumor drugs such as interferon and cisplatin and operation modes such as cervical ring-cutting, wherein the antitumor drugs have large toxic and side effects, long treatment course, low cure rate and difficult popularization; the cervical ring incision requires surgery, and the sequelae are severe.
Patients with cervical cancer-related diseases generally do not show obvious symptoms, or only have symptoms of general cervicitis, such as leucorrhea increase, and complaints about leucorrhea blood or little vaginal bleeding after sexual contact. It belongs to the categories of leukorrhagia, metrorrhagia, abdominal mass and the like in the field of traditional Chinese medicine, and is formed by considering that the core pathogenesis of the disease is the deficiency of healthy qi and the accumulation of damp-heat and blood stasis toxin in the uterus subphylum due to the external infection of damp-heat and toxin and dirt. The therapeutic principle should be heat-clearing and detoxicating, promoting blood circulation and resolving hard mass, removing putrefaction and promoting granulation. For example, patent application CN113456730A discloses a traditional Chinese medicine composition for treating cervical precancerous lesion caused by HPV infection, which is prepared from salvia miltiorrhiza, sophora flavescens, radix sileris, verbena, fresh stiff silkworm and fresh centipede through separation and purification technical design, so that the problem of poor stability caused by polypeptide, phenolic acid and alkaloid components is solved, and meanwhile, the formula is mainly prepared from dampness-heat-toxin clearing and stasis-removing herbs, so that the negative conversion rate of HPV infection can be greatly improved. However, the composition contains a lot of cold components, and long-term administration of the composition may damage female health and is not beneficial to disease recovery.
Disclosure of Invention
Based on the defects of the prior art, the invention provides the traditional Chinese medicine composition for treating the cervical precancerous lesion, which is mainly prepared from medicines with mild medicine properties, has the effects of cooling blood, regulating nutrient, promoting qi circulation, removing stasis and not damaging yin, can treat the cervical precancerous lesion, and avoids the damage to the health of women.
Therefore, the invention provides a traditional Chinese medicine composition for treating cervical precancerous lesions, which comprises, by weight, 80-120 parts of glabrous greenbrier rhizome, 40-55 parts of common mallow herb, 56-72 parts of false grape, 19-37 parts of rhizoma podophylli, 55-75 parts of rhizoma atractylodis, 22-30 parts of nidus vespae, 60-70 parts of frankincense, 30-40 parts of myrrh, 42-58 parts of astragalus, 22-33 parts of dragon blood and 18-35 parts of liquorice.
Preferably, the traditional Chinese medicine composition for treating cervical precancerous lesion comprises, by weight, 100 parts of glabrous greenbrier rhizome, 48 parts of common malted licorice root, 65 parts of muscadine, 22 parts of hirsutella sinensis, 65 parts of rhizoma atractylodis, 26 parts of nidus vespae, 65 parts of frankincense, 35 parts of myrrh, 51 parts of astragalus mongholicus, 27 parts of dragon's blood and 22 parts of liquorice.
The invention further provides a preparation method of the traditional Chinese medicine composition for treating cervical precancerous lesions, which comprises the following steps:
(1) Soaking nidus Vespae in sodium chloride solution, performing steam distillation, removing the distillation solvent, and keeping the residue;
(2) Extracting nidus Vespae residue and other materials with ethanol under reflux, collecting the residue, concentrating the extractive solution, and drying to obtain extract 1;
(3) And (3) decocting the residues in water, concentrating the decoction, adding ethanol for precipitation, drying the precipitate to obtain an extract 2, and mixing the extract 2 with the extract 1 to obtain the traditional Chinese medicine composition for treating cervical precancerous lesions.
Preferably, the concentration of the sodium chloride solution in the step (1) is 2.5-5%.
Preferably, the ratio of the mass of the nidus vespae to the volume of the sodium chloride solution in the step (1) is 1.
Preferably, the soaking time in the step (1) is 30-60min, and/or the distillation time is 2-4h.
Preferably, the volume percentage of the ethanol in the step (2) is 70-80%.
Preferably, the volume ratio of the total mass of the medicinal materials in the step (2) to the ethanol is 1 to 9-12, and the relationship of the mass to the volume ratio is g/mL.
Preferably, the reflux leaching temperature in the step (2) is 50-60 ℃, and the leaching time is 30-50min.
Preferably, the mass ratio of the dregs of a decoction to the water in the step (3) is 1.
Preferably, the decocting time in the step (3) is 1-2h.
Preferably, the decoction in the step (3) is concentrated to 1/8-1/10 of the original volume.
Preferably, the volume percentage of the ethanol added in the step (3) is 90-100%, and the volume of the ethanol is 3-5 times of that of the decoction concentrated solution.
The invention also provides an oral preparation for treating cervical precancerous lesions, which comprises the composition or the composition prepared by the preparation method and pharmaceutically acceptable auxiliary materials.
Preferably, the oral preparation is selected from one of granules, tablets, capsules and oral liquid.
Preferably, the oral preparation is an oral liquid, and the preparation method comprises the following steps: dissolving sucrose and potassium sorbate in water, adding the composition for treating cervical precancerous lesions, dissolving, filtering, collecting filtrate, adding water to desired volume, bottling, and sterilizing.
Preferably, the addition amount of the sucrose is 5-10%, and the addition amount of the potassium sorbate is 0.1-0.2%.
The invention has the beneficial effects that:
1. the invention provides a traditional Chinese medicine composition for treating cervical precancerous lesions, which comprises, by weight, 80-120 parts of glabrous greenbrier rhizome, 40-55 parts of common mallow herb, 56-72 parts of grape, 19-37 parts of rhizoma pilei, 55-75 parts of rhizoma atractylodis, 22-30 parts of nidus vespae, 60-70 parts of frankincense, 30-40 parts of myrrh, 42-58 parts of astragalus, 22-33 parts of dragon blood and 18-35 parts of liquorice. Wherein the glabrous greenbrier rhizome is the monarch drug of the invention; the wheat bran grass, the vitis amurensis, the rhizoma polygoni multiflori, the rhizoma atractylodis and the nidus vespae have the effects of clearing away damp-heat, dispelling wind and eliminating toxin, and cooperate with the rhizoma smilacis glabrae to play the drug effect, so that the Chinese medicinal preparation is a ministerial medicament of the invention; olibanum and Myrrha with blood circulation promoting and stagnation resolving effects, and radix astragali and sanguis Draxonis with necrotic tissue removing and granulation promoting effects are used as adjuvant drugs; licorice root, radix Glycyrrhizae coordinates the effects of the other drugs in the recipe, and acts as a guiding drug. The medicines are mutually compatible, blood cooling and nutrition are not harmful to body resistance, qi circulation is promoted to remove stasis and yin is not harmful to body resistance, the effects of clearing damp heat toxin, removing stasis and strengthening body resistance to consolidate the constitution are achieved, the precancerous lesion of cervical cancer can be effectively treated, and the cervical cancer is prevented from continuously developing and evolving.
2. The composition of the invention is warm and mild medicines, does not damage the spleen and stomach of a patient after long-term use, is beneficial to the physical rehabilitation, and has the following specific effects:
smilax glabra, sweet and bland, enters liver and stomach meridians. Has the effects of removing dampness, removing toxic substances, and smoothing joint movement. Can be used for treating damp-heat stranguria with turbid discharge, leukorrhagia, carbuncle swelling, scrofula, scabies, tinea, syphilis and limb spasm and arthralgia and myalgia caused by mercury poisoning.
Wheat bran grass, pungent; slightly bitter; the nature is mild. Has the functions of dispelling wind and relieving itching; the actions of removing toxicity and promoting warm. Skin itching is predominant; sores and rashes due to dampness and toxicity.
The fake grapes are bitter and astringent in taste; the nature is flat; it enters lung, liver and kidney meridians and has the functions of relaxing muscles and tendons, promoting blood circulation, clearing away heat and toxic material, promoting granulation and eliminating dampness. It can be used for treating fracture, rheumatic paralysis, fatigue, undefined lump, and dysentery.
Radix seu folium Cayratiae Oligocarpae, bitter; the nature is mild. Clearing away damp-heat; the efficacy of dispelling wind. Jaundice due to damp-heat pathogen; painful urination; arthralgia due to wind-damp-heat.
Rhizoma Atractylodis, pungent and bitter; and (4) temperature. Has the effects of eliminating dampness, strengthening spleen, dispelling wind, dispelling cold and improving eyesight, and can be used for treating abdominal distention, diarrhea, edema, tinea pedis, 36484m, rheumatalgia, wind-cold type common cold and nyctalopia.
Nidus Vespae is bitter, salty and flat, has the effects of dispelling pathogenic wind, removing toxic substances, killing parasites and stopping carbuncle, and can be used for treating symptoms such as malignant boil, tumor, rash and pruritus.
Ru Xiang is pungent, bitter and warm. Has effects of promoting blood circulation and relieving pain. Can be used for treating pain of heart and abdomen, spasm of tendons and vessels, traumatic injury, skin ulcer, carbuncle, and swelling and pain; it can be used topically for detumescence and granulation promotion.
Mo Yao, ping. Has the functions of dissipating blood stasis, relieving pain, dispersing swelling and promoting tissue regeneration. Can be used for treating traumatic injury, blood stasis, swelling and pain, carbuncle, cellulitis, and chest and abdomen pain; it is indicated for long-term sore without astringency.
Huang Qi is sweet and warm. It enters lung and spleen meridians. Has the effects of invigorating qi, consolidating exterior, promoting urination, expelling toxin, expelling pus, healing sore and promoting granulation. Can be used for treating deficiency of vital energy, asthenia, anorexia, loose stool, collapse of middle-warmer energy, chronic diarrhea, rectocele, hematochezia, metrorrhagia, exterior deficiency, spontaneous perspiration, qi deficiency, edema, carbuncle, cellulitis, ulcer, chronic ulcer, blood deficiency, debility with jaundice, internal heat, and diabetes; proteinuria due to chronic nephritis and diabetes.
Dragon's blood is sweet, salty and neutral. It enters heart and liver meridians. Has the effects of removing blood stasis, relieving pain, stopping bleeding and promoting granulation. Can be used for treating traumatic injury, internal injury, blood stasis and pain; bleeding caused by trauma is not limited.
Licorice root, radix Glycyrrhizae, sweet and neutral. It enters heart, lung, spleen and stomach meridians. Has the effects of invigorating spleen and replenishing qi, clearing away heat and toxic materials, eliminating phlegm and stopping cough, relieving spasm and pain, and harmonizing the drugs. Can be used for treating weakness of spleen and stomach, asthenia, palpitation, short breath, cough, excessive phlegm, abdominal and limb spasm, pain, carbuncle, swelling, sore, and drug toxicity and strong nature.
3. Compared with common external preparations such as gel, ointment and the like, the composition provided by the invention has slow effect, but belongs to fundamental treatment, and has higher drug absorption rate and conversion rate and better treatment effect in the long term. In addition, the toxic component of the nidus Vespae, namely the nidus Vespae oil, is removed by a steam distillation method in the preparation process, so that the safety of the medicine is improved.
Detailed Description
The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall relate to the scope of protection of the present invention.
Example 1
The embodiment provides a traditional Chinese medicine composition for treating cervical precancerous lesion, which comprises, by weight, 100g of glabrous greenbrier rhizome, 48g of common malpigweed herb, 65g of muscadine, 22g of rhizoma pileiae, 65g of rhizoma atractylodis, 26g of nidus vespae, 65g of frankincense, 35g of myrrh, 51g of astragalus, 27g of dragon blood and 22g of liquorice.
The preparation method of the traditional Chinese medicine composition for treating cervical precancerous lesion comprises the following steps:
(1) Soaking nidus Vespae in 220mL of 4% sodium chloride solution for 45min, performing steam distillation for 3h, removing the distillation solvent, and keeping the residue;
(2) Adding 5200mL of 75% ethanol into nidus Vespae residue and other materials, reflux-extracting at 55 deg.C for 40min, keeping the residue, concentrating the extractive solution to obtain extract, and drying in a vacuum drying oven at 45 deg.C for 24 hr to obtain extract 1;
(3) And (3) adding 3200mL of water into the decoction dregs obtained in the step (2), decocting for 1.5h, concentrating the decoction to 350mL, adding 1400mL of 95% ethanol, standing at 4 ℃ for precipitation for 24h, filtering and collecting precipitates, drying in a vacuum drying oven at 45 ℃ for 24h to obtain an extract 2, and mixing the extract 2 with the extract 1 to obtain the traditional Chinese medicine composition for treating the precancerous lesion of the cervical carcinoma.
Preparing the composition into oral solution, weighing 50g of sucrose and 1.5g of potassium sorbate, adding 500mL of water for dissolving, adding the prepared composition for dissolving, filtering, adding water for fixing the volume to 1000mL, filling into a bottle of 10mL, and sterilizing.
Example 2
The embodiment provides a traditional Chinese medicine composition for treating cervical precancerous lesions, which comprises 80g of rhizoma smilacis glabrae, 40g of wheat bran grass, 72g of grape pseudobulb, 37g of rhizoma podophylli, 75g of rhizoma atractylodis, 22g of nidus vespae, 60g of frankincense, 30g of myrrh, 42g of radix astragali, 20g of dragon blood and 35g of liquorice in parts by weight.
The preparation method of the traditional Chinese medicine composition for treating cervical precancerous lesion comprises the following steps:
(1) Soaking nidus Vespae in 220mL of 5% sodium chloride solution for 60min, performing steam distillation for 2h, removing the distillation solvent, and keeping the residue;
(2) Adding 4700mL of 70% ethanol into nidus Vespae residue and other materials, reflux-extracting at 50 deg.C for 50min, keeping the residue, concentrating the extractive solution to obtain extract, and drying in vacuum oven at 45 deg.C for 24 hr to obtain extract 1;
(3) And (3) adding 3500mL of water into the medicine residues in the step (2), decocting for 2h, concentrating the decoction to 350mL, adding 1050mL of 90% ethanol, standing at 4 ℃ for precipitation for 24h, filtering and collecting the precipitate, drying in a vacuum drying oven at 45 ℃ for 24h to obtain an extract 2, and mixing the extract 2 with the extract 1 to obtain the traditional Chinese medicine composition for treating the cervical precancerous lesions.
Preparing the composition into oral solution, weighing 100g of sucrose and 1.0g of potassium sorbate, adding 500mL of water for dissolving, adding the prepared composition for dissolving, filtering, adding water for fixing the volume to 1000mL, filling into a bottle of 10mL, and sterilizing.
Example 3
The embodiment provides a traditional Chinese medicine composition for treating cervical precancerous lesion, which comprises, by weight, 120g of glabrous greenbrier rhizome, 55g of common malpigweed herb, 56g of muscadine, 19g of rhizoma pileiae, 55g of rhizoma atractylodis, 30g of nidus vespae, 70g of frankincense, 40g of myrrh, 58g of astragalus, 33g of dragon blood and 18g of liquorice.
The preparation method of the traditional Chinese medicine composition for treating cervical precancerous lesion comprises the following steps:
(1) Soaking nidus Vespae in 210mL of 2.5% sodium chloride solution for 30min, steam distilling for 4 hr, removing the distilled solvent, and keeping the residue;
(2) Adding 6600mL of 80% ethanol into nidus Vespae residue and other materials, reflux extracting at 60 deg.C for 30min, keeping the residue, concentrating the extractive solution to obtain extract, and drying in vacuum drying oven at 45 deg.C for 24 hr to obtain extract 1;
(3) And (3) adding 2800mL of water into the medicine residues in the step (2), decocting for 1h, concentrating the decoction to 350mL, adding 1750mL of absolute ethyl alcohol, standing at 4 ℃ for precipitation for 24h, filtering and collecting precipitates, drying in a vacuum drying box at 45 ℃ for 24h to obtain an extract 2, and mixing the extract 2 with the extract 1 to obtain the traditional Chinese medicine composition for treating the cervical precancerous lesions.
Preparing the composition into oral solution, firstly weighing 75g of sucrose and 2g of potassium sorbate, adding 500mL of water for dissolving, then adding the prepared composition for dissolving, filtering, adding water for fixing the volume to 1000mL, filling into a bottle of 10mL, and sterilizing to obtain the oral solution.
Comparative example 1
The comparative example provides a traditional Chinese medicine composition for treating cervical precancerous lesions, which is different from example 1 only in that rhizoma atractylodis is replaced by rhizoma atractylodis macrocephalae.
Comparative example 2
The comparative example provides a traditional Chinese medicine composition for treating cervical precancerous lesions, and compared with example 1, the difference is only that the dragon blood is replaced by the pseudo-ginseng.
Experimental example 1
The activity of the composition for inhibiting the proliferation of Hela cells is examined, and the specific method is as follows:
the cell proliferation inhibition rate of Hela was measured by MTT method (cell proliferation and cytotoxicity assay kit, available from Shanghai Shangbao Biotech Co., ltd., product number 20311). Preparing Hela cells in logarithmic growth phase into single cell suspension, and regulating cell density to 2 × 10 5 200 μ L per well of 96-well culture plate, at 37 deg.C, 5% 2 The culture box is used for culturing for 4 hours.
Serum-free culture medium is added into the blank control group, the positive control group is cisplatin solution with the concentration of 10ug/ml, and the examples 1 to 3 are oral liquid of the examples 1 to 3 respectively; comparative examples 1-2 are oral liquids of comparative examples 1 and 2, respectively. mu.L of the above sample was added to each well, and after culturing for 72 hours, 20. Mu.L of MTT (5 g/L) was added, and the mixture was incubated at 37 ℃ for 4 hours, and the supernatant was discarded, 200. Mu.L of DMSO was added to each well, and the crystals were dissolved by shaking, and the absorbance (A) value at 490nm was measured to calculate the cell growth inhibition ratio.
Cell growth inhibition = (1-sample a value/blank a value) × 100%, the results are shown in table 1.
TABLE 1 inhibition of Hela cell proliferation (%)
| Inhibition ratio (%) | |
| Blank control group | 0 |
| Positive control group | 70.47±3.09 |
| Example 1 | 79.44±2.73 |
| Example 2 | 80.03±1.97 |
| Example 3 | 77.79±2.55 |
| Comparative example 1 | 62.19±3.17 |
| Comparative example 2 | 54.73±2.29 |
The data in Table 1 show that the composition can effectively inhibit the proliferation of Hela cells, has the effect equivalent to or even higher than that of cisplatin, and can replace the cisplatin for treatment so as to avoid the toxic and side effects of the cisplatin. In addition, after the rhizoma atractylodis is replaced by the rhizoma atractylodis macrocephalae and the dragon's blood is replaced by the pseudo-ginseng, the effect of the composition for inhibiting the proliferation of Hela cells is obviously reduced, which shows that the curative effect is poor, so that the components of the composition provided by the invention have a synergistic effect, and the replacement of the components can cause the reduction of the curative effect.
Experimental example 2
The effect of the composition of the present invention in clinical application was examined.
100 cases of cervical cancer pre-lesion patients caused by HPV infection (through liquid-based ultrathin technology, colposcopy and histopathological detection, the pathological result is clear as the cervical cancer pre-lesion) are selected and randomly divided into four groups: example 1, cisplatin group, 50 people each, patients between each group had no significant difference in age, gender (P > 0.05), and were comparable.
Example 1 the oral liquid prepared in example 1 was taken 1 pill a day 3 times a day after meals for 3 months. Cis-platinum group: dissolving with normal saline before application, each time according to body surface area of 20mg/m 2 The administration is repeated for 5 days at 2 weeks intervals. The results are shown in Table 2.
Treatment criteria are as follows:
(1) The method has the following advantages: both TCT and HPV detection were negative. Colposcopy, e.g., no abnormal findings under the scope or no presence of CIN as confirmed by biopathological examination, was also interpreted as effective.
(2) And (4) invalidation: grade CIN1 or grade CIN2 of pathological diagnosis remains unchanged after biopsy.
TABLE 2 clinical results of the compositions of the present application for the treatment of pre-cervical lesions
| Is effective | Invalidation | High efficiency | |
| Example 1 | 38 | 12 | 76％ |
| Cis platinum group | 35 | 15 | 70％ |
The data in table 2 show that the effect of the traditional Chinese medicine composition for clinically treating cervical precancerous lesions is equivalent to that of a cisplatin medicine, but compared with the cisplatin medicine, the traditional Chinese medicine composition provided by the invention is high in safety, small in toxic and side effects and wide in application prospect.
The present invention is not limited to the above preferred embodiments, and any modifications, equivalent substitutions, improvements, etc. within the spirit and principle of the present invention should be included in the protection scope of the present invention.
Claims (10)
1. A traditional Chinese medicine composition for treating cervical precancerous lesions is characterized by comprising, by weight, 80-120 parts of rhizoma smilacis glabrae, 40-55 parts of wheat bran grass, 56-72 parts of pseudogrape, 19-37 parts of rhizoma podophylli, 55-75 parts of rhizoma atractylodis, 22-30 parts of nidus vespae, 60-70 parts of frankincense, 30-40 parts of myrrh, 42-58 parts of astragalus membranaceus, 22-33 parts of dragon blood and 18-35 parts of liquorice.
2. The traditional Chinese medicine composition for treating cervical precancerous lesion of claim 1, which comprises, by weight, 100 parts of glabrous greenbrier rhizome, 48 parts of common malted spurge herb, 65 parts of amur grape, 22 parts of rhizoma pilei, 65 parts of rhizoma atractylodis, 26 parts of nidus vespae, 65 parts of frankincense, 35 parts of myrrh, 51 parts of astragalus membranaceus, 27 parts of dragon's blood and 22 parts of liquorice.
3. The preparation method of the traditional Chinese medicine composition for treating cervical precancerous lesions as claimed in claim 1 or 2, is characterized by comprising the following steps:
(1) Soaking nidus Vespae in sodium chloride solution, performing steam distillation, removing the distillation solvent, and keeping the residue;
(2) Extracting nidus Vespae residue and other materials with ethanol under reflux, keeping the residue, concentrating the extractive solution, and drying to obtain extract 1;
(3) And (3) decocting the medicine residues in the step (2) with water, concentrating the decoction, adding ethanol for precipitation, drying the precipitate to obtain an extract 2, and mixing the extract 2 with the extract 1 to obtain the traditional Chinese medicine composition for treating cervical precancerous lesions.
4. The method according to claim 3, wherein the step (1) further satisfies any one of the following:
(A) The concentration of the sodium chloride solution is 2.5-5%;
(B) The volume ratio of the mass of the nidus vespae to the sodium chloride solution is 1-10, and the relationship of the mass to the volume ratio is g/mL;
(C) Soaking for 30-60min;
(D) The distillation time is 2-4h.
5. The production method according to claim 3, wherein the step (2) further satisfies any one of the following:
(A) The volume percentage of the ethanol is 70-80 percent;
(B) The volume ratio of the total mass of the medicinal materials to the ethanol is 1-12, and the relationship of the mass to the volume ratio is g/mL;
(C) The reflux extraction temperature is 50-60 deg.C, and the extraction time is 30-50min.
6. The production method according to claim 3, wherein the step (3) further satisfies any one of the following:
(A) The mass ratio of the medicine residues to the water is 1-7;
(B) The decoction time is 1-2h;
(C) The decoction is concentrated to 1/8-1/10 of the original volume.
7. The method of claim 3, wherein the ethanol added in step (3) is 90 to 100 vol%, and the volume of ethanol is 3 to 5 times that of the decoction concentrate.
8. An oral preparation for treating cervical cancer precursor lesions, which is characterized by comprising the composition of claim 1 or 2 or the composition prepared by the preparation method of any one of claims 3 to 7 and pharmaceutically acceptable auxiliary materials.
9. The oral preparation according to claim 8, wherein the oral preparation is an oral liquid, and the preparation method comprises dissolving sucrose and potassium sorbate in water, adding the composition for treating cervical precancerous lesions, dissolving, filtering, collecting the filtrate, adding water to a constant volume, filling, and sterilizing.
10. The oral preparation according to claim 9, wherein the sucrose is added in an amount of 5 to 10% and the potassium sorbate is added in an amount of 0.1 to 0.2%.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202211664438.0A CN115804823B (en) | 2022-12-23 | 2022-12-23 | Traditional Chinese medicine composition for treating cervical cancer precursor lesions |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202211664438.0A CN115804823B (en) | 2022-12-23 | 2022-12-23 | Traditional Chinese medicine composition for treating cervical cancer precursor lesions |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN115804823A true CN115804823A (en) | 2023-03-17 |
| CN115804823B CN115804823B (en) | 2024-02-06 |
Family
ID=85486635
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202211664438.0A Active CN115804823B (en) | 2022-12-23 | 2022-12-23 | Traditional Chinese medicine composition for treating cervical cancer precursor lesions |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN115804823B (en) |
Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1502343A (en) * | 2002-11-21 | 2004-06-09 | 余世春 | Pain-eliminating anti-cancer traditional Chinese medicine and preparation process thereof |
| CN107823426A (en) * | 2017-12-07 | 2018-03-23 | 吉林农业大学 | It is a kind of to treat ox into Chinese medicine composition of carbuncle phase pulmonary abscess and preparation method thereof |
| CN109157594A (en) * | 2018-11-26 | 2019-01-08 | 西安百世惠众生物工程有限公司 | A kind of pure Chinese medicinal preparation and preparation method thereof for treating fibroid and cervical erosion |
| CN111097030A (en) * | 2020-01-18 | 2020-05-05 | 刘彬 | Traditional Chinese medicine composition for treating tumors and relieving tumor pain and preparation method thereof |
| CN114848780A (en) * | 2022-05-27 | 2022-08-05 | 广东罗浮山国药股份有限公司 | Traditional Chinese medicine composition for preventing postoperative recurrence of endometriosis and preparation method thereof |
| CN115089695A (en) * | 2022-08-09 | 2022-09-23 | 广东罗浮山国药股份有限公司 | Composition with endometrial cancer treatment effect and preparation method thereof |
| CN115227766A (en) * | 2022-08-26 | 2022-10-25 | 广东罗浮山国药股份有限公司 | Pharmaceutical composition for improving mammary gland function of lying-in woman and preparation method thereof |
-
2022
- 2022-12-23 CN CN202211664438.0A patent/CN115804823B/en active Active
Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1502343A (en) * | 2002-11-21 | 2004-06-09 | 余世春 | Pain-eliminating anti-cancer traditional Chinese medicine and preparation process thereof |
| CN107823426A (en) * | 2017-12-07 | 2018-03-23 | 吉林农业大学 | It is a kind of to treat ox into Chinese medicine composition of carbuncle phase pulmonary abscess and preparation method thereof |
| CN109157594A (en) * | 2018-11-26 | 2019-01-08 | 西安百世惠众生物工程有限公司 | A kind of pure Chinese medicinal preparation and preparation method thereof for treating fibroid and cervical erosion |
| CN111097030A (en) * | 2020-01-18 | 2020-05-05 | 刘彬 | Traditional Chinese medicine composition for treating tumors and relieving tumor pain and preparation method thereof |
| CN114848780A (en) * | 2022-05-27 | 2022-08-05 | 广东罗浮山国药股份有限公司 | Traditional Chinese medicine composition for preventing postoperative recurrence of endometriosis and preparation method thereof |
| CN115089695A (en) * | 2022-08-09 | 2022-09-23 | 广东罗浮山国药股份有限公司 | Composition with endometrial cancer treatment effect and preparation method thereof |
| CN115227766A (en) * | 2022-08-26 | 2022-10-25 | 广东罗浮山国药股份有限公司 | Pharmaceutical composition for improving mammary gland function of lying-in woman and preparation method thereof |
Non-Patent Citations (5)
| Title |
|---|
| 何进: "张焱治疗癌痛经验", 四川中医, no. 02, pages 2 - 3 * |
| 宋风辉，等: "微波联合中药治疗宫颈糜烂180例临床观察", 河北医药, vol. 31, no. 17, pages 2331 * |
| 张清民，等: "消炎利胆分散片治疗急性咽炎的药效学研究", 今日药学, vol. 26, no. 03, pages 156 - 158 * |
| 梁惠珍，等: "宫颈炎Ⅰ号方治疗宫颈糜烂(湿热瘀结型)30例临床观察", 中医药导报, vol. 17, no. 03, pages 29 - 30 * |
| 高源，等: "苗药猪鬃草研究进展综述", 海峡药学, vol. 32, no. 01, pages 42 - 45 * |
Also Published As
| Publication number | Publication date |
|---|---|
| CN115804823B (en) | 2024-02-06 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN113599481B (en) | Traditional Chinese medicine composition for treating thyroid diseases and preparation method and application thereof | |
| CN104225441A (en) | Traditional Chinese medicine composition for treating stomach trouble and preparation method of granules and capsules of traditional Chinese medicine composition | |
| CN109966434B (en) | Traditional Chinese medicine composition, traditional Chinese medicine compound preparation, and preparation method and application thereof | |
| CN106421673A (en) | Traditional Chinese medicine composition for treating HPV (human papillomavirus) infection and preparation method thereof | |
| CN103877289A (en) | Medicine for treating breast cancer and preparation method of medicine | |
| CN104383317A (en) | Chinese traditional medicine composition for treating liver cancer | |
| CN102908391B (en) | Chinese medicinal composition for treating dermatosis and preparation method and application thereof | |
| CN102846739B (en) | Navel-applied plaster for treating hepatitis and preparation method thereof | |
| WO2019104931A1 (en) | Traditional chinese medicine composition for treating leukaemia and preparation method therefor | |
| CN115804823A (en) | Traditional Chinese medicine composition for treating cervical precancerous lesions | |
| CN104162093A (en) | Traditional Chinese medicinal preparation for treating breast cancer, and preparation method thereof | |
| CN106822733B (en) | Ointment for treating precancerous lesion of chronic atrophic gastritis and preparation method thereof | |
| CN113384646A (en) | Traditional Chinese medicine composition for treating hand-foot syndrome and application thereof | |
| CN106334171A (en) | Traditional Chinese medicine preparation for repairing liver damage and preparation method thereof | |
| CN105288180A (en) | Traditional Chinese medicine composition for treating early and middle gastric cancer and preparation method of traditional Chinese medicine composition for treating early and middle gastric cancer | |
| CN109602790A (en) | A kind of Chinese medicine composition that treating malignant pleural effusion with lung cancer and its preparation and application | |
| CN114588240B (en) | Traditional Chinese medicine composition for treating colorectal cancer and preparation method and application thereof | |
| CN113952435B (en) | Traditional Chinese medicine composition for adjuvant treatment of liver cancer and preparation method thereof | |
| CN1256976C (en) | Anti-cancer Chinese medicinal composition and its preparing method | |
| CN112755135A (en) | Traditional Chinese medicine composition for treating HPV (human papilloma Virus) persistent infection and application | |
| CN105477246A (en) | Traditional Chinese medicine composition for treating phlegmatic hygrosis type mammary gland hyperplasia and preparation method thereof | |
| CN114601907A (en) | Traditional Chinese medicine ointment for treating breast cancer and preparation method thereof | |
| CN117323395A (en) | Traditional Chinese medicine composition for treating HPV infection, traditional Chinese medicine agent and application thereof | |
| CN114939143A (en) | Navel patch and oral preparation for treating constipation after intestinal cancer surgery | |
| CN115025171A (en) | Traditional Chinese medicine composition and preparation for treating autoimmune diseases and preparation method thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant |