CN115778613A

CN115778613A - Universal type auxiliary device for intravenous injection of rat tail

Info

Publication number: CN115778613A
Application number: CN202310026012.0A
Authority: CN
Inventors: 曹放; 刘占良; 林哲闽; 牛亦农
Original assignee: Beijing Shijitan Hospital
Current assignee: Beijing Shijitan Hospital
Priority date: 2023-01-09
Filing date: 2023-01-09
Publication date: 2023-03-14
Anticipated expiration: 2043-01-09
Also published as: CN115778613B

Abstract

The invention discloses a universal type auxiliary device for rat tail intravenous injection, which comprises: an operation table; the mouse fixing part is arranged at the top of the operating platform; the mouse fixing part is used for locking limbs of a mouse; a tail clamping part inserted into the operation table from the top of the operation table; the mouse tail clamping part is used for clamping the tail of a mouse; the lighting part is arranged in the operating table and is positioned in the direction in which the mouse tail clamping part is far away from the mouse fixing part; the lighting part is used for searching for the vein of the tail part of the mouse; the auxiliary part comprises a flexible supporting arm, a clamp, a base frame, a tightener and a locking wire; one end of the supporting arm is connected with the clamp holder, and the other end of the supporting arm is connected with the underframe; one end of the locking wire penetrates through the bottom frame and the supporting arm in sequence and then is fixedly connected with the clamp holder, and the other end of the locking wire is wound on the tightener.

Description

Universal type auxiliary device for intravenous injection of rat tail

Technical Field

The invention belongs to the technical field of medical instruments, and particularly relates to a universal type auxiliary device for rat tail intravenous injection.

Background

In mouse/nude mouse animal experiments, drugs or tumor cells need to be injected through tail vein to construct relevant animal models, which is one of the most commonly used operations in animal experiments. In the tail vein injection process, the following phenomena frequently occur due to small diameter and thin lumen of tail vein blood vessels of mice:

1. after the experimenter successfully punctures, because the diameter of the rat tail vein vessel is small, even if the experimenter moves slightly, the needle point of the injector can be led to exit the tube cavity and enter the subcutaneous part by mistake, so in order to avoid the hand displacement, the injector is not generally drawn back after the puncture, the experimenter only needs to judge whether the injector is positioned in the vessel cavity or not according to the experience, if the puncture is inserted into the subcutaneous part by mistake, the injection of the medicine or the tumor cells is carried out at the moment, the medicine liquid or the cells can be injected into the rat tail subcutaneous part greatly, and the waste is caused;

2. even if experiential and skillful puncture techniques are realized, as the tail vein injection operation is performed in a state that the mouse is awake, if the mouse is agitated or hands of experimenters shake during the operation, the tip of the injector cannot be ensured not to be displaced or changed in angle during the injection process of the injector, and once the displacement occurs, the tail vein is easy to puncture or exit from a tube cavity, so that the local hematoma seriously influences the next injection; the stimulated vein can not be full in a short time (3 hours) due to spasm, so that the injection time is delayed, and the experimental process is influenced;

3. in the injection process, the rat tail vein is thin and is greatly influenced by low temperature, so that the rat tail vein is easily in a contraction state, and the operation difficulty is increased. In order to dilate veins, the rat tails need to be repeatedly immersed in warm water, and are gently rubbed to stimulate the vasodilatation, so that the pain of experimental animals is increased; even so, the vein expanded in a short time due to blood backflow can still be quickly returned to the original thickness, thereby increasing the injection difficulty;

4. when the puncture part is positioned, because the current light source mostly comes from a certain indoor fixed point light source, the puncture part is easily shielded by an operator's operating hand, so that the puncture part is not illuminated enough, and the injection is influenced; the invention aims at the problems and provides a universal type auxiliary device for tail intravenous injection.

Disclosure of Invention

In order to overcome the problems set forth in the background of the invention, the present invention provides a universal type rat tail intravenous injection assisting device.

Universal formula rat tail intravenous route auxiliary device includes:

an operation table;

the mouse fixing part is arranged at the top of the operating platform; the mouse fixing part is used for locking four limbs of a mouse;

a tail clamping part inserted into the operation table from the top of the operation table; the rat tail clamping part is used for clamping the rat tail root part;

the lighting part is arranged in the operating table and is positioned in the direction in which the mouse tail clamping part is far away from the mouse fixing part; the lighting part is used for searching for the vein of the tail part of the mouse;

the auxiliary part comprises a flexible supporting arm, a clamp, a base frame, a tightener and a locking wire; one end of the supporting arm is connected with the clamp holder, and the other end of the supporting arm is connected with the underframe; one end of the locking wire penetrates through the bottom frame and the supporting arm in sequence and then is fixedly connected with the clamp holder, and the other end of the locking wire is wound on the tightener.

Further, the support arm includes a first support structure and a second support structure; the first support structures and the second support structures are alternately arranged; the inside of first bearing structure and second bearing structure all sets up the via hole with the locking silk adaptation.

Further, a guide groove matched with the mouse tail clamping part and a placing table for placing the mouse tail are arranged at the top of the operating table; an adjusting groove matched with the lighting part is arranged on the side wall of the operating platform.

Further, the mouse fixing part comprises a fixing table and a fixer; the bottom of the fixed table is fixedly connected with the operating table; the fixer and the fixed station are separated and fixed at the top of the fixed station.

Further, the rat tail clamping part comprises a clamping roller and a driving part; the bottom of the clamping roller is inserted into the operating table and connected with the driving part.

Further, the driving part comprises an adjusting handle and a rotating roller; one end of the rotating roller is inserted into the operating table from the side wall of the operating table and is in threaded connection with the bottom of the clamping roller, and the other end of the rotating roller is connected with the adjusting handle.

Further, the illumination portion comprises a controller, an illuminating lamp and a moving arm; the controller is connected with the illuminating lamp through a wire; the moving arm is inserted into the operation table from the side wall of the operation table and then is connected with the bottom of the illuminating lamp.

Further, the holder comprises a connector, a guider, an adjuster and a limiter; one end of the connector is connected with the supporting arm and the locking wire, and the other end of the connector is fixedly connected with the guider; the regulator penetrates into the guide from the top of the guide and then is connected with the limiter.

Further, the underframe comprises a support frame and a fixed frame; the top of the supporting frame is connected with the supporting arm, and the bottom of the supporting frame is fixedly connected with the fixing frame; the supporting frame and the fixing frame are internally provided with through holes matched with the locking wires.

Further, the tightener comprises a tightening handle and a tightening roller; one end of the tightening roller penetrates into the operating platform from the side wall of the operating platform to be connected with the locking wire, and the other end of the tightening roller is connected with the tightening handle.

The invention has the beneficial effects that: the auxiliary support is provided for tail vein injection of the mouse, so that an experimenter is assisted to puncture or withdraw a tail vein, after puncture, the stability of the injector is guaranteed, the experimenter is allowed to withdraw and verify that the injector is positioned in a tube cavity, and waste of liquid medicine/cell suspension is avoided; even if the hands of the experimenter shake, the displacement or angle change of the needle head in the injection process can not occur, the condition that the injection cannot be successfully carried out due to the puncture of the tail vein or the vein withdrawal is effectively prevented, and the delay of the experiment time caused by the puncture failure is avoided; meanwhile, the device increases the venous filling degree by fixing and lightly clamping the tail root part of the rat before injection; the local shadow caused by the fact that an extra point light source is shielded by a hand is avoided by bottom light source irradiation during injection, and the operation difficulty can be greatly reduced by the auxiliary device.

Drawings

FIG. 1 is a top view of a gimbaled caudal intravenous injection aid embodying the present invention;

FIG. 2 is a schematic structural diagram of a universal type auxiliary device for rat tail intravenous injection according to the present invention;

FIG. 3 is a front view of a universal type rat tail intravenous injection aid embodying the present invention;

FIG. 4 is a side view of a universal rat tail intravenous injection aid embodying the present invention;

FIG. 5 isbase:Sub>A sectional view taken along line A-A of FIG. 4;

FIG. 6 is a sectional view taken along line B-B of FIG. 4;

in the figure, 1, an operation table; 11. a guide groove; 12. a placing table; 13. an adjustment groove; 2. a mouse fixing part; 21. a fixed table; 22. a holder; 3. a mouse tail clamping part; 31. a grip roll; 32. an adjusting handle; 33. a rotating roller; 4. an illumination unit; 41. a controller; 42. an illuminating lamp; 43. a motion arm; 5. an auxiliary part; 51. a holder; 511. a connector; 512. a guide; 513. a regulator; 514. a stopper; 52. a support arm; 521. a first support structure; 522. a second support structure; 53. a chassis; 531. a support frame; 532. a fixed mount; 54. a tightener; 541. tightening the handle; 542. a take-up roll; 55. and (4) locking the wires.

Detailed Description

The technical solutions in the embodiments of the present invention are clearly and completely described below by specific embodiments, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, rather than all embodiments, and other advantages and effects of the present invention can be easily understood by those skilled in the art from the disclosure of the present specification. The present invention can be implemented or applied by other different specific embodiments, and the features in the following embodiments and embodiments can be combined with each other without conflict, and all other embodiments obtained by a person of ordinary skill in the art without creative efforts based on the embodiments of the present invention belong to the protection scope of the present invention.

The universal type rat tail intravenous injection auxiliary device shown in fig. 1 comprises:

an operation table 1;

a mouse fixing part 2 arranged on the top of the operation table 1; the mouse fixing part 2 is used for locking the limbs of a mouse;

a tail clamping part 3 inserted into the operation table 1 from the top of the operation table 1; the rat tail clamping part 3 is used for clamping the rat tail root;

an illumination part 4 arranged in the operation table 1 and positioned in the direction that the rat tail clamping part 3 is far away from the rat fixing part 2; the lighting part 4 is used for searching the vein of the rat tail;

the auxiliary part 5, the clamper 51 comprises a flexible supporting arm 52, the clamper 51, a base frame 53, a tightener 54 and a locking wire 55; one end of the supporting arm 52 is connected with the clamper 51, and the other end is connected with the base frame 53; one end of the locking wire 55 passes through the base frame 53 and the supporting arm 52 in sequence and is fixedly connected with the clamper 51, and the other end is wound on the tightener 54.

The operation table 1 is a hollow regular plate-shaped structure, and the internal cabin provides a space for the working of the tail clamping part 3, the lighting part 4 and the auxiliary part 5. When the mouse fixing device is used, the four limbs and the trunk of a mouse are fixed on the mouse fixing part 2, then the tail clamping part 3 is used for clamping the tail root part, so that the backflow of tail venous blood is reduced, the tail vein is full, and the injection is convenient. The illumination section 4 is then turned on and the illumination section 4 is adjusted to the proper position to more clearly see the tail vein. Finally, the needle tube is clamped in the holder 51, the supporting arm 52 is adjusted to enable the needle tip to be aligned with the rat tail vein, and then the locking wire 55 is tensioned by the tightener 54 to lock the shape of the supporting arm 52, so that the experimenter can perform puncture operation on the rat tail vein.

Specifically, as shown in fig. 3, the support arm 52 includes two or more first support structures 521 and two or more second support structures 522; the number of the first supporting structures 521 arranged alternately with the second supporting structures 522 is larger than that of the second supporting structures 522, and both ends of the supporting arm 52 are the first supporting structures 521. The first supporting structure 521 is a spherical structure, and the second supporting structure 522 is a columnar structure with spherical grooves at two ends; the first support structure 521 and the second support structure 522 are provided with through holes adapted to the locking wires 55. The tightener 54 is rotated to loosen the locking wire 55, the shape of the support arm 52 is adjusted to align the needle tip of the syringe with the rat tail vein, and then the tightener 54 is reversed to tighten the locking wire 55 to lock the support arm 52, so that the support arm 52 maintains the adjusted shape.

As shown in fig. 1-4, a guide slot 11 adapted to the mouse tail holding part 3 and a holding table 12 for holding the mouse tail are provided on the top of the operation table 1; an adjustment groove 13 adapted to the illumination section 4 is provided in a side wall of the console 1.

As shown in fig. 2, the mouse fixing part 2 includes a fixing table 21 and a fixer 22; the bottom of the fixed table 21 is fixedly connected with the operating table 1; the holder 22 is separated from the fixing table 21 and fixed to the top of the fixing table 21. The retainer 22 is of a U-shaped configuration. Preferably, four anchors 22 are provided, one for each limb of the mouse. The fixer 22 is locked with the fixing table 21 through bolts, the limbs of the mouse are fixed on the fixing table 21, then the tail of the mouse is flatly laid on the placing table 12, and the tail clamping part 3 is used for clamping the tail of the mouse.

As shown in fig. 2 and 6, the tail nip portion 3 includes a nip roller 31 and a driving portion; the bottom of the grip roller 31 is inserted into the inside of the table 1 through the guide groove 11 and connected to the driving section. Specifically, set up two grip rollers 31, the top of grip roller 31 is expanded, and two grip rollers 31 clip the root of a rat tail from both sides, make the backward flow of tail vein blood reduce, and the tail vein is abundant, makes things convenient for the injection. The bottom of the pinch roller 31 is connected to a drive unit, and the drive unit causes the two pinch rollers 31 to move in opposite directions or in opposite directions at the same speed, thereby pinching the tail of the mouse.

As shown in fig. 6, the driving portion includes an adjustment handle 32 and a rotating roller 33; one end of the rotating roller 33 is inserted into the operation table 1 from the side wall of the operation table 1 and is screwed to the bottom of the grip roller 31, and the other end is connected to the adjustment handle 32. Two sets of threads are arranged on the rotating roller 33, and the two sets of threads have different rotating directions and the same thread pitch. The grip rollers 31 are kept moving in opposite or opposite directions at the same speed by turning the adjustment handle 32. The reversal adjusting handle 32 drives the two clamping rollers 31 to move oppositely at the same time, the rat tail clamping part is opened by 3, after the rat tail is placed on the placing table 12, the reversal adjusting handle 32 drives the two clamping rollers 31 to move oppositely at the same time, and the rat tail part is clamped from two sides by the two clamps.

Preferably, a slideway adapted to the grip roller 31 is provided inside the operation table 1, the slideway corresponding to the guide groove 11. The slideway and the guide groove 11 define the motion track of the clamping roller 31, so that the clamping roller 31 can only do reciprocating linear motion in the guide groove 11 along the slideway. The rotating frame matched with the rotating roller 33 is arranged on the inner side wall of the operating platform 1, one end of the rotating roller 33 is rotatably connected with the rotating frame, the middle part of the rotating frame is in threaded connection with the clamping roller 31, the other end of the rotating frame is rotatably connected with the operating platform 1 when penetrating through the operating platform 1, and the other end of the rotating frame is connected with the adjusting handle 32 after penetrating through the operating platform 1.

In some embodiments of the present application, the driving portion is a tension spring, both ends of the driving portion are respectively connected to the bottoms of the two grip rollers 31, the grip rollers 31 are pulled apart, the mouse tail is placed on the mouse tail grip portion 3, and then the grip rollers 31 are loosened, and the grip rollers 31 are driven by the tension spring to grip the mouse tail root from both sides.

As shown in fig. 2 to 4, the illumination section 4 includes a controller 41, an illumination lamp 42, and a moving arm 43; the controller 41 is connected with the illuminating lamp 42 through a wire; the moving arm 43 is inserted into the operation table 1 from the adjustment groove 13 and then connected to the bottom of the illumination lamp 42. The application controller 41 turns on the illumination lamp 42, and pushes the moving arm 43 to slide in the adjusting slot 13, so as to drive the illumination lamp 42 to slide on the top of the operation table 1. The tail vein can be seen clearly by the light part emitted by the illuminating lamp 42 penetrating through the tail of the mouse, and the illuminating lamp 42 is adjusted to a proper position by moving the arm 43 to find the most proper position for puncture. When the lamp 42 reaches the proper position, the moving arm 43 is not moved any more.

As shown in fig. 3, the holder 51 includes a connector 511, a guide 512, an adjuster 513, and a stopper 514; one end of the connector 511 is connected to the support arm 52 and the locking wire 55, and the other end is fixedly connected to the guide 512; the adjuster 513 is connected to the stopper 514 after passing through the top of the guide 512 into the inside of the guide 512.

Specifically, the actuator 513 is threadably coupled to the guide 512, the actuator 513 is rotatably coupled to the stop 514, and the actuator 513 is rotated to urge the stop 514 to move within the guide 512. The position of the stopper 514 is adjusted according to the type of syringe used for puncturing, so that different types of syringes can be fitted inside the holder 51.

As shown in fig. 3 and 5, the bottom frame 53 includes a support frame 531 and a fixing frame 532; the top of the supporting frame 531 is connected to the first supporting structure 521, and the bottom is fixedly connected to the fixing frame 532; through holes matched with the locking wires 55 are formed in the supporting frame 531 and the fixing frame 532. Specifically, the supporting frame 531 is a column structure with a spherical groove on the top.

As shown in fig. 5, the tightener 54 includes a tightening handle 541 and a tightening roller 542; one end of the tightening roller 542 penetrates the inside of the console 1 from the side wall of the console 1 to be connected to the lock wire 55, and the other end is connected to the tightening handle 541.

Specifically, the inside of operation panel 1 sets up the rotation support with tightening roller 542 adaptation, and the one end of tightening roller 542 rotates with the rotation support to be connected, and the middle part is connected with locking wire 55, and the other end rotates with operation panel 1 when passing operation panel 1 to be connected, passes operation panel 1 after and is connected with tightening handle 541, rotates tightening handle 541, drives tightening roller 542 and rotates, tightens up or unclamps locking wire 55 according to the rotation of rotation handle to.

The above description of the embodiments is only for the understanding of the present invention. It should be noted that modifications could be made to the invention without departing from the principle of the invention, which would also fall within the scope of the claims of the invention.

Claims

1. Universal formula tail intravenous route auxiliary device, its characterized in that includes:

an operation table;

the mouse fixing part is arranged at the top of the operating platform; the mouse fixing part is used for locking limbs of a mouse;

the lighting part is arranged in the operating table and is positioned in the direction in which the mouse tail clamping part is far away from the mouse fixing part; the lighting part is used for searching the tail vein of the mouse;

2. The gimbaled rat tail intravenous assist device of claim 1, wherein the support arm comprises a first support structure and a second support structure; the first supporting structures and the second supporting structures are alternately arranged; the inside of first bearing structure and second bearing structure all sets up the via hole with the locking silk adaptation.

3. The universal type auxiliary device for intravenous injection of rat tail according to claim 1, wherein a guide groove for fitting with the rat tail clamping part and a placing table for placing the rat tail are arranged at the top of the operating table; an adjusting groove matched with the lighting part is arranged on the side wall of the operating platform.

4. The universal rat caudal intravenous injection aid of claim 1, wherein said rat fixation portion comprises a fixation table and a fixation device; the bottom of the fixed table is fixedly connected with the operating table; the fixer and the fixed station are separated and fixed at the top of the fixed station.

5. The gimbaled rat tail intravenous injection aid of claim 1, wherein the rat tail grip comprises a grip roller and a drive; the bottom of the clamping roller is inserted into the operating table and connected with the driving part.

6. The gimbaled rat tail intravenous injection aid of claim 5, wherein the drive section comprises an adjustment handle and a rotating roller; one end of the rotating roller is inserted into the operating table from the side wall of the operating table and is in threaded connection with the bottom of the clamping roller, and the other end of the rotating roller is connected with the adjusting handle.

7. The gimbaled rat tail intravenous injection aid of claim 1, wherein the illumination portion comprises a controller, an illumination lamp, and a motion arm; the controller is connected with the illuminating lamp through a wire; the moving arm is inserted into the operation table from the side wall of the operation table and then connected with the bottom of the illuminating lamp.

8. The gimbaled rat tail intravenous injection aid of any one of claims 1-7, wherein the holder comprises a connector, a guide, an adjuster, and a stop; one end of the connector is connected with the supporting arm and the locking wire, and the other end of the connector is fixedly connected with the guider; the regulator penetrates into the guide from the top of the guide and then is connected with the limiter.

9. The gimbaled rat tail intravenous injection aid of claim 8, wherein the base frame comprises a support frame and a mount; the top of the supporting frame is connected with the supporting arm, and the bottom of the supporting frame is fixedly connected with the fixing frame; the support frame all sets up the through-hole with the locking screw adaptation with the inside of mount.

10. The gimbaled rat tail intravenous injection aid of claim 8, wherein the tightener comprises a tightening handle and a tightening roller; one end of the tightening roller penetrates into the operating platform from the side wall of the operating platform to be connected with the locking wire, and the other end of the tightening roller is connected with the tightening handle.