CN115770276A - Method for improving efficacy and stability of rheumatalgia medicinal liquor - Google Patents
Method for improving efficacy and stability of rheumatalgia medicinal liquor Download PDFInfo
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Abstract
The invention discloses a production method of rheumatalgia medicinal liquor, which takes twenty seven medicinal materials of Chinese photinia herb, ephedra herb, bitter orange, cassia twig, silkworm excrement, sealwort, dried orange peel, officinal magnolia bark, bitter apricot seed, oriental waterplantain rhizome, common yam rhizome, swordlike atractylodes rhizome, tree peony bark, szechuan lovage rhizome, largehead atractylodes rhizome, dahurian angelica root, costus root, umbilicaria esculenta, incised notopterygium rhizome, common fennel fruit, fructus gleditsiae, malaytea scurfpea fruit, nutgrass galingale rhizome, south dodder seed, myrrh, chinese angelica and frankincense as main raw materials, adopts a two-time white spirit percolation method, and combines a polytetrafluoroethylene membrane treated by taking polyoxyethylene laurate, alkyl glucoside, nano aluminum oxide and absolute ethyl alcohol as modifiers, so that the medicine effect and the stability of the product are effectively improved; and egg white powder and bentonite are taken as clarifying agents, so that the clarifying rate is increased, and the product stability can be further improved.
Description
Technical Field
The invention relates to a method for improving the drug effect and stability of rheumatalgia medicinal liquor.
Background
Rheumatism is a group of diseases mainly attacking joints, bones, muscles, blood vessels and related soft tissues or connective tissues, and most of them are autoimmune diseases. The disease is more hidden and slow, the disease course is longer, most diseases have genetic tendency, and diagnosis and treatment are difficult to achieve. Rheumatism often accompanies pain, the whole body can not be painful when the rheumatism is severe, the rheumatism is difficult to cure at present, certain diseases need lifelong treatment, western medicines in the aspect of treatment have good pain relieving effect and quick effect, but can not radically cure the pain, the pain can be recurrent, and side effects such as blood and liver and kidney function damage can be generated after long-term use. Compared with western medicines, the traditional Chinese medicine has smaller side effect, but the traditional Chinese medicine is generally decocted at high temperature to extract effective components, and partial effective components are heated and decomposed under the high temperature condition, so that the drug effect is reduced.
Medicated wine, a leaching preparation which integrates the wine of beverage and medicines for curing diseases and strengthening the body, has been in China for thousands of years. The medicinal liquor has the advantages of simple preparation and taking, stable medicinal property, safety and effectiveness. At present, medicinal liquor for treating rheumatalgia is available on the market, but the medicinal effect is not obvious, the clarity of the medicinal liquor is low, and turbid precipitation can be generated after long-time storage or under the condition of low temperature.
Disclosure of Invention
The technical problem to be solved by the invention is as follows: provides a production technology of medicinal liquor with strong efficacy, high clarity and strong stability for rheumatalgia.
In order to solve the technical problem, the technical scheme adopted by the invention comprises the following steps:
(1) Taking 1 standard prescription dose of twenty-seven medicinal materials of piper wallichii, ephedra, bitter orange, cassia twig, silkworm excrement, rhizoma polygonati, dried orange peel, mangnolia officinalis, bitter apricot seed, rhizoma alismatis, chinese yam, rhizoma atractylodis, tree peony bark, ligusticum wallichii, rhizoma atractylodis macrocephalae, radix angelicae, elecampane, umbilicaria esculenta, notopterygium root, fennel, fructus gleditsiae, fructus psoraleae, rhizoma cyperi, semen cuscutae, myrrh, angelica and frankincense.
(2) Adding water into the south China Photinia to immerse the south China Photinia, decocting for two times, each time for 2 hours, combining the decoctions, filtering, and concentrating the filtrate into clear paste with the relative density of 1.10-1.20 (80 ℃).
(3) Pulverizing the rest twenty-six medicinal materials into coarse powder, leaching the effective components of the medicinal materials by a percolation method, mixing 1026g of 70-degree white spirit and sucrose fatty acid ester accounting for 0.1-0.2% of the mass of the white spirit to percolate the medicinal materials, mixing 1026g of 40-degree white spirit and dodecanoic acid accounting for 2-4% of the mass of the white spirit to percolate the medicinal materials, combining the percolates of the two times, and then carrying out centrifugal filtration to obtain the percolate.
(4) And combining the percolate and the concentrated solution, adding 225g of brown sugar, stirring and dissolving, adding a clarified solution with the volume of 0.3-0.7% of the medicinal liquor into the medicinal liquor, stirring for 40-50 minutes, then transferring the medicinal liquor into an environment with the temperature of-10 to-5 ℃, standing for 72 hours, filtering and precipitating when the medicinal liquor is cold, then adding a 15% concentration acetic acid solution with the volume of 0.4-0.6% of the medicinal liquor into the medicinal liquor, stirring, standing for 48 hours, and filtering and precipitating to obtain the finished medicinal liquor.
The standard prescription dose is 2812g of Chinese photinia stem, 94g of ephedra herb, 75g of bitter orange, 75g of cassia twig, 24g of silkworm excrement, 30g of rhizoma polygonati, 50g of dried orange peel, 11g of mangnolia officinalis, 11g of bitter apricot seed, 11g of rhizoma alismatis, 11g of Chinese yam, 11g of rhizoma atractylodis, 11g of tree peony bark, 11g of ligusticum wallichii, 11g of bighead atractylodes rhizome, 11g of angelica dahurica, 11g of costus root, 11g of concha haliotidis, 11g of notopterygium root, 11g of fennel, 11g of fructus gleditsiae, 11g of fructus psoraleae, 11g of rhizoma cyperi, 11g of semen cuscutae, 11g of myrrh, 11g of angelica and 11g of frankincense.
Further, the particle size of the coarse powder in the step (3) is required to be 60-65% of powder which can pass through a 24-mesh sieve, 50-mesh sieve and 65-mesh sieve: 25% -30%: 5% -15%.
Further, the preparation method of the filtration membrane in the centrifugal filtration step in (3) is as follows: mixing polyoxyethylene laurate, alkyl glucoside, nano alumina and absolute ethyl alcohol according to the weight ratio of 2:0.5 to 1.5:2~3:35 to 45 mass percent, and stirring uniformly to prepare a modified solution. And then, putting the polytetrafluoroethylene-based membrane into the solution, immersing for 20 minutes, putting the polytetrafluoroethylene-based membrane into a vacuum drying oven at the temperature of 80-100 ℃ after immersion is finished, drying for 10-20 minutes, circulating for 3 times in the way, and finally cooling to room temperature to obtain the centrifugal filtration membrane.
Further, the preparation method of the clarified liquid in the step (4) is that the egg white powder and the bentonite are mixed according to the proportion of 1:1.5 to 2.5, adding deionized water with the mass of 6~8 times of the egg white powder at 30 to 40 ℃ into the egg white powder, stirring for 10 minutes, adding bentonite, continuing stirring for 20 minutes, and uniformly dispersing the egg white powder and the bentonite to obtain a clarified liquid.
The invention has the beneficial effects that:
(1) After the medicinal materials are crushed, the granularity is too fine, the blockage is easy, the adsorbability is enhanced, and the leaching effect is poor; is too coarse and not easy to compress, has small contact surface between the solvent and the medicinal materials, and is not beneficial to leaching. The proper fineness can accelerate the percolation speed and reduce the working procedure time.
(2) Two kinds of white spirit with different degrees can leach two kinds of effective substances with alcohol solubility and water solubility to the maximum extent, the value of medicinal materials is utilized to the maximum extent, and the effect of sterilization and disinfection can be achieved by percolating the white spirit with higher degree.
(3) The sucrose fatty acid ester of the monoester has a high HLB value, can be used as a solubilizer for alcohol-soluble substances such as alkaloids, sterols, terpenes and the like, transfers part of the alcohol-soluble substances in the ethanol to a water phase to increase the precipitation of the alcohol-soluble substances in medicinal materials, and has the characteristics of no odor, no toxicity and strong biodegradability compared with other solubilizers.
(4) The dodecanoic acid is insoluble in water, so that amino acid and other substances in the water phase can be extracted into the organic phase by the dodecanoic acid, so that the precipitation of water-soluble substances in medicinal materials is increased, and the dodecanoic acid is strong in stability, non-toxic, also is a surfactant and can play a synergistic effect with sucrose fatty acid ester, so that various components of the medicinal liquor can be better fused together.
(5) The polyoxyethylene laurate and the alkyl glucoside are hydrophilic surfactants, and can adsorb a part of inorganic salt while filtering granular and particulate substances by a filter membrane, thereby improving the clarity of the medicinal liquor and enhancing the stability of the medicinal liquor. This also increases the filtration rate of the organic phase in the medicated liquor.
(6) In the nanometer characteristics of the nanometer alumina, the larger specific surface area and specific surface energy can enhance the adsorbability of the filter membrane, the extremely small particle size can be used as a pore-foaming agent to enhance the compactness of the filter membrane, and the high hardness can enhance the mechanical strength and toughness of the filter membrane.
(7) Because the aqueous solution of the alkyl glycoside is strong in alkalinity, and the polyoxyethylene laurate is easy to hydrolyze under the conditions of strong acid and strong alkali, deionized water cannot be selected as a solvent, the nano-alumina can be uniformly dispersed in ethanol without adding a dispersing agent, the ethanol is also a solvent with strong volatility, and the addition process is not needed during removal, so that the time and the labor are saved.
(8) The egg white powder can react with tannin in ineffective components to form precipitate, the precipitate is completely removed, and the rest suspension can adsorb macromolecular substances with reduced solubility due to low temperature, so that the precipitation standing rate is accelerated.
(9) The low-temperature precipitation treatment can not only effectively remove the active ingredients of the medicinal liquor, but also remove the inactive ingredients in the medicinal liquor, effectively solves the problem that the medicinal liquor is easy to precipitate and then is turbid at low temperature, and greatly enhances the stability of the medicinal liquor.
(10) The finally added acetic acid solution can remove protein precipitate remained in the protein powder, and the redundant acetic acid can be used as a raw material for producing ethyl acetate by the reaction of the medicinal liquor, so that the generation of the aroma of the medicinal liquor is accelerated.
Detailed Description
The present invention will be described in further detail with reference to examples.
Example 1
(1) 28120g of south China herb, 940g of ephedra herb, 750g of bitter orange, 750g of cassia twig, 240g of silkworm excrement, 300g of rhizoma polygonati, 500g of dried orange peel, 110g of mangnolia officinalis, 110g of bitter apricot seed, 110g of rhizoma alismatis, 110g of Chinese yam, 110g of rhizoma atractylodis, 110g of moutan bark, 110g of ligusticum wallichii, 110g of rhizoma atractylodis macrocephalae, 110g of radix angelicae, 110g of elecampane, 110g of umbilicaria esculenta, 110g of notopterygium root, 110g of fennel, 110g of fructus gleditsiae, 110g of fructus psoraleae, 110g of rhizoma cyperi, 110g of semen cuscutae, 110g of myrrh, 110g of angelica and 110g of frankincense.
(2) Adding water into the celastrus orbiculatus until the celastrus orbiculatus is immersed, decocting twice, each time for 2 hours, mixing decoctions, filtering, and concentrating the filtrate into clear paste with the relative density of 1.10-1.20 (80 ℃).
(3) The rest twenty-six medicinal materials are crushed into coarse powder, and are respectively sieved by a 24-mesh sieve, a 50-mesh sieve and a 65-mesh sieve, and then are sieved by the 24-mesh sieve, the 50-mesh sieve and the 65-mesh sieve according to the proportion of 63%:27%: the proportion is 10 percent. The effective components of the medicinal materials are leached out by a percolation method, the medicinal materials are firstly percolated by mixing 10260g of 70-degree white spirit and sucrose fatty acid ester accounting for 0.15% of the mass of the white spirit, then the medicinal materials are percolated by mixing 10260g of 40-degree white spirit and dodecanoic acid accounting for 3% of the mass of the white spirit, and the percolated liquid obtained in the two times is combined.
(4) Mixing polyoxyethylene laurate, alkyl glucoside, nano alumina and absolute ethyl alcohol according to the weight ratio of 2:1.0:2.5:40, uniformly stirring to prepare a modified solution, then putting the polytetrafluoroethylene-based membrane into the solution to be immersed for 20 minutes, putting the polytetrafluoroethylene-based membrane into a vacuum drying oven with the temperature of 90 ℃ to be dried for 15 minutes after the immersion is finished, circulating for 3 times in the way, and cooling to room temperature to obtain the centrifugal filtration membrane. And then carrying out centrifugal filtration on the percolate to obtain the percolate.
(5) Mixing egg white powder and bentonite according to the proportion of 1:2, adding 196g of deionized water at 35 ℃ into 28g of egg white powder, stirring for 10 minutes, adding bentonite, continuing stirring for 20 minutes, and uniformly dispersing the egg white powder and the bentonite to obtain a clarified liquid. Mixing the percolate with the caulis et folium piperis clear paste, adding 2250g of brown sugar, stirring for dissolving, adding 0.5% of clear solution of medicated liquor volume into the medicated liquor, stirring for 45 minutes, standing at-7 deg.C for 72 hours, filtering and precipitating while cooling, adding 0.5% of 15% of medicated liquor volume of acetic acid solution, stirring, standing for 48 hours, filtering and precipitating to obtain the final product.
Example 2
(1) 28120g of south China herb, 940g of ephedra herb, 750g of bitter orange, 750g of cassia twig, 240g of silkworm excrement, 300g of rhizoma polygonati, 500g of dried orange peel, 110g of mangnolia officinalis, 110g of bitter apricot seed, 110g of rhizoma alismatis, 110g of Chinese yam, 110g of rhizoma atractylodis, 110g of moutan bark, 110g of ligusticum wallichii, 110g of rhizoma atractylodis macrocephalae, 110g of radix angelicae, 110g of elecampane, 110g of umbilicaria esculenta, 110g of notopterygium root, 110g of fennel, 110g of fructus gleditsiae, 110g of fructus psoraleae, 110g of rhizoma cyperi, 110g of semen cuscutae, 110g of myrrh, 110g of angelica and 110g of frankincense.
(2) Adding water into the celastrus orbiculatus until the celastrus orbiculatus is immersed, decocting twice, each time for 2 hours, mixing decoctions, filtering, and concentrating the filtrate into clear paste with the relative density of 1.10-1.20 (80 ℃).
(3) The rest twenty-six medicinal materials are crushed into coarse powder, and are respectively sieved by a 24-mesh sieve, a 50-mesh sieve and a 65-mesh sieve, and then are sieved by the 24-mesh sieve, the 50-mesh sieve and the 65-mesh sieve according to the proportion of 65%:30%: the proportion of 5 percent is proportioned. The effective components of the medicinal materials are leached out by a percolation method, the medicinal materials are firstly percolated by mixing 10260g of 70-degree white spirit and sucrose fatty acid ester accounting for 0.2% of the mass of the white spirit, then the medicinal materials are percolated by mixing 10260g of 40-degree white spirit and dodecanoic acid accounting for 2% of the mass of the white spirit, and the percolated liquid obtained in the two times is combined.
(4) Mixing polyoxyethylene laurate, alkyl glucoside, nano alumina and absolute ethyl alcohol according to the weight ratio of 2:0.5:3:35, and uniformly stirring to obtain the modified solution. And then, putting the polytetrafluoroethylene-based membrane into the solution, immersing for 20 minutes, putting the polytetrafluoroethylene-based membrane into a vacuum drying oven with the temperature of 80 ℃ after immersion, drying for 20 minutes, circulating for 3 times in the way, and cooling to room temperature to obtain the modified filter membrane. And then carrying out centrifugal filtration on the percolate to obtain the percolate.
(5) Mixing egg white powder and bentonite according to the proportion of 1:2.5, firstly adding 224g of deionized water at 40 ℃ into 28g of egg white powder, stirring for 10 minutes, then adding bentonite, continuing stirring for 20 minutes, and uniformly dispersing the egg white powder and the bentonite to obtain the clarified liquid. Mixing the percolate with the caulis et folium piperis clear paste, adding 2250g of brown sugar, stirring for dissolving, adding 0.7% of clear solution of medicated liquor volume into the medicated liquor, stirring for 40 min, standing at-5 deg.C for 72 hr, filtering to precipitate when it is cold, adding 0.4% of 15% of medicated liquor volume of acetic acid solution, stirring, standing for 48 hr, filtering, and precipitating to obtain the final product.
Example 3
(1) 28120g of south China herb, 940g of ephedra herb, 750g of bitter orange, 750g of cassia twig, 240g of silkworm excrement, 300g of rhizoma polygonati, 500g of dried orange peel, 110g of mangnolia officinalis, 110g of bitter apricot seed, 110g of rhizoma alismatis, 110g of Chinese yam, 110g of rhizoma atractylodis, 110g of moutan bark, 110g of ligusticum wallichii, 110g of rhizoma atractylodis macrocephalae, 110g of radix angelicae, 110g of elecampane, 110g of umbilicaria esculenta, 110g of notopterygium root, 110g of fennel, 110g of fructus gleditsiae, 110g of fructus psoraleae, 110g of rhizoma cyperi, 110g of semen cuscutae, 110g of myrrh, 110g of angelica and 110g of frankincense.
(2) Adding water into the celastrus orbiculatus until the celastrus orbiculatus is immersed, decocting twice, each time for 2 hours, mixing decoctions, filtering, and concentrating the filtrate into clear paste with the relative density of 1.10-1.20 (80 ℃).
(3) The rest twenty-six medicinal materials are crushed into coarse powder, and are respectively sieved by a 24-mesh sieve, a 50-mesh sieve and a 65-mesh sieve, and then are sieved by the 24-mesh sieve, the 50-mesh sieve and the 65-mesh sieve according to the proportion of 60%:25%:15 percent of the components are proportioned. The effective components of the medicinal materials are leached out by a percolation method, the medicinal materials are firstly percolated by mixing 10260g of 70-degree white spirit and sucrose fatty acid ester accounting for 0.1% of the mass of the white spirit, then the medicinal materials are percolated by mixing 10260g of 40-degree white spirit and dodecanoic acid accounting for 4% of the mass of the white spirit, and the percolated liquid obtained in the two times is combined.
(4) Mixing polyoxyethylene laurate, alkyl glucoside, nano alumina and absolute ethyl alcohol according to the weight ratio of 2:1.5:2:45, stirring uniformly to prepare a modified solution, then putting the polytetrafluoroethylene-based membrane into the solution to be immersed for 20 minutes, putting the polytetrafluoroethylene-based membrane into a vacuum drying oven at the temperature of 100 ℃ to be dried for 10 minutes after the immersion is finished, circulating the operation for 3 times, and cooling to room temperature to obtain the centrifugal filtration membrane. And then carrying out centrifugal filtration on the percolate to obtain the percolate.
(5) Mixing egg white powder and bentonite according to the proportion of 1:1.5, adding 128g of 30 ℃ deionized water into 28g of egg white powder, stirring for 10 minutes, adding bentonite, continuing stirring for 20 minutes, and uniformly dispersing the egg white powder and the bentonite to obtain a clarified liquid. Mixing the percolate with the caulis et folium piperis clear paste, adding 2250g of brown sugar, stirring for dissolving, adding 0.3% of clear solution of medicated liquor volume into the medicated liquor, stirring for 50 minutes, standing at-10 deg.C for 72 hours, filtering and precipitating while cooling, adding 0.6% of 15% of acetic acid solution of medicated liquor volume into the medicated liquor, stirring, standing for 48 hours, and filtering and precipitating to obtain the final product.
Comparative example 1
The difference between the comparative example and the example 1 is that the grain size of the coarse powder is the medicinal powder which can only pass through a 24-mesh sieve, and during the percolation, only 16070g of 70-degree white spirit and sucrose fatty acid ester accounting for 0.15 percent of the mass of the white spirit are mixed to be used as a solvent for percolation once.
Comparative example 2
The difference between the comparative example and the example 1 is that the grain size of the coarse powder is the powder which can only pass through a 65-mesh sieve, and the coarse powder is percolated once by using 28125g of 40-degree white spirit and a dodecanoic acid mixed solvent which accounts for 3 percent of the mass of the white spirit.
Comparative example 3
The difference between the comparative example and the example 1 is that only 10260g of 70-degree white spirit and 10260g of 40-degree white spirit are used as solvents for percolation for once respectively.
Comparative example 4
This comparative example differs from example 2 in that no nano-alumina was added to the membrane modification solution.
Comparative example 5
This comparative example differs from example 2 in that no polyoxyethylene laurate or alkyl glycoside is added to the membrane modification solution.
Comparative example 6
This comparative example differs from example 2 in that the filter membrane was not impregnated with the modification solution.
Comparative example 7
This comparative example is different from example 3 in that the clear solution added to the medicated wine was a gelatin solution of 0.05 g/ml.
Comparative example 8
This comparative example differs from example 3 in that no 15% strength acetic acid solution was added to the medicated wine.
Comparative example 9
This comparative example differs from example 3 in that no low-temperature treatment was performed.
The technical characteristics and technical indexes of the medicinal liquor prepared in the examples 1, 2 and 3 of the invention are compared and shown in table 1.
Note: the technical parameters not listed are detailed in the examples.
The technical characteristics and technical indexes of the process of the medicinal liquor of the embodiment 1 of the invention are compared with those of the medicinal liquor of the comparative examples 1, 2 and 3, and are shown in the table 2.
Note: the technical parameters not listed are detailed in the examples.
The technical characteristics and technical indexes of the process of the medicinal liquor of example 2 of the invention are compared with those of the medicinal liquor of comparative examples 4, 5 and 6, and are shown in Table 3.
Note: the technical parameters not listed are detailed in the examples.
Examples 1, 2, 3 and comparative examples 7, 8, 9 were subjected to the following procedure stability test: 200ml of medicinal liquor is put into a flask with a stirrer, and is sequentially stirred in salt bath at 20 ℃, 16 ℃, 12 ℃, 8 ℃, 4 ℃, 0 ℃, 4 ℃, 8 ℃ and 12 ℃, the stirring speed is 800r/min, the stirring time is 5min, and whether the medicinal liquor generates precipitates is observed.
The technical characteristics and technical indexes of the process of the medicinal liquor of the examples 1, 2 and 3 of the invention are compared with those of the medicinal liquor of the comparative examples 7, 8 and 9, and are shown in the table 4.
Note: the technical parameters not listed are detailed in the examples.
The data in tables 1, 2, 3 and 4 show that the method can effectively enhance the precipitation of the effective components of the medicinal liquor under the condition of the same dosage of medicinal materials, thereby enhancing the medicinal effect and reducing the cost; the clarity of the liquid medicine is improved through centrifugal filtration, and the time cost is greatly reduced compared with the traditional standing filtration method; the stability of the medicinal liquor is obviously improved, so that the medicinal liquor can not generate precipitate under the condition of low temperature and long-time storage.
Claims (4)
1. A preparation method of the rheumatalgia medicinal liquor is characterized by comprising the following steps:
the preparation method specifically comprises the following steps:
(1) Taking twenty-seven medicinal materials of caulis et folium piperis, ephedra, fructus aurantii, cassia twig, silkworm excrement, rhizoma polygonati, dried orange peel, mangnolia officinalis, bitter apricot seed, rhizoma alismatis, chinese yam, rhizoma atractylodis, cortex moutan, ligusticum wallichii, rhizoma atractylodis macrocephalae, radix angelicae, elecampane, umbilicaria esculenta, notopterygium root, fennel, fructus gleditsiae, fructus psoraleae, rhizoma cyperi, semen cuscutae, myrrh, angelica and frankincense according to standard prescription amount;
(2) Adding water into the celastrus orbiculatus until the celastrus orbiculatus is immersed, decocting twice, each time for 2 hours, mixing decoctions, filtering, and concentrating the filtrate to obtain clear paste with the relative density of 1.10-1.20 at 80 ℃;
(3) Pulverizing the rest twenty-six medicinal materials into coarse powder, leaching effective components of the medicinal materials by adopting a percolation method, mixing 1026g of white spirit with the degree of 70 degrees and sucrose fatty acid ester accounting for 0.1-0.2% of the mass of the white spirit to percolate the medicinal materials, mixing 1026g of white spirit with the degree of 40 degrees and dodecanoic acid accounting for 2-4% of the mass of the white spirit to percolate the medicinal materials, combining two percolates, and then carrying out centrifugal filtration to obtain a percolate;
(4) And mixing the percolate and the clear paste, adding 225g of brown sugar, stirring for dissolving, adding clarified liquid accounting for 0.3-0.7% of the volume of the medicinal liquor into the medicinal liquor, stirring for 40-50 minutes, then transferring the mixture into an environment with the temperature of minus 10-minus 5 ℃, standing for 72 hours, filtering and precipitating when the mixture is cold, then adding an acetic acid solution with the concentration of 15% of the volume of the medicinal liquor accounting for 0.4-0.6% of the volume of the medicinal liquor into the medicinal liquor, stirring, standing for 48 hours, and filtering and precipitating to obtain the finished medicinal liquor.
2. A method for preparing a rheumatalgia medicated wine according to claim 1, wherein the method comprises the following steps: the particle size of the coarse powder in the step (3) is 60-65% of powder sieved by a 24-mesh sieve, 50-mesh sieve and 65-mesh sieve: 25% -30%: 5% -15% of the total weight of the composition.
3. A centrifugal filtration membrane for use in the preparation of rheumatalgia medicated wine of claim 1, wherein: the preparation method of the filtering membrane comprises the following steps: mixing polyoxyethylene laurate, alkyl glucoside, nano alumina and absolute ethyl alcohol according to the weight ratio of 2:0.5 to 1.5:2~3: and (2) mixing the components according to the mass ratio of 35 to 45, uniformly stirring the components to prepare a modified solution, then immersing a polytetrafluoroethylene-based membrane in the solution for 20 minutes, after immersing, putting the polytetrafluoroethylene-based membrane in a vacuum drying oven at the temperature of 80 to 100 ℃ for drying for 10 to 20 minutes, circulating the immersion and drying for 3 times, and finally cooling the membrane to room temperature to obtain the centrifugal filtration membrane.
4. A clear liquid for use in the preparation of the rheumatalgia-relieving medicated wine of claim 1, characterized in that: the preparation method of the clear liquid comprises the following steps of mixing egg white powder and bentonite according to a ratio of 1:1.5 to 2.5, adding deionized water with the mass of 6~8 times of the egg white powder at 30 to 40 ℃ into the egg white powder, stirring for 10 minutes, adding bentonite, continuing stirring for 20 minutes, and uniformly dispersing the egg white powder and the bentonite to obtain a clarified liquid.
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Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104189463A (en) * | 2014-08-07 | 2014-12-10 | 江西九华药业有限公司 | Rheumatism pain medicinal liquor and preparation method thereof |
| CN106582298A (en) * | 2016-12-09 | 2017-04-26 | 西安建筑科技大学 | Three-dimensional GO sheet sphere particle modified organic composite ultra/micro filtering membrane preparing method |
| CN108498696A (en) * | 2018-05-28 | 2018-09-07 | 江西九华药业有限公司 | It is a kind of to be used to treat chill pain in waist and lower extremities, the vina preparation process of muscles and bones numbness |
| CN115093921A (en) * | 2022-07-19 | 2022-09-23 | 江西樟树市庆仁保健品有限公司 | Preparation method of traditional Chinese medicine extract for health care wine |
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