CN115769077A - 用于治疗癌症的方法和组合物 - Google Patents

用于治疗癌症的方法和组合物 Download PDF

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Publication number
CN115769077A
CN115769077A CN202180039991.2A CN202180039991A CN115769077A CN 115769077 A CN115769077 A CN 115769077A CN 202180039991 A CN202180039991 A CN 202180039991A CN 115769077 A CN115769077 A CN 115769077A
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China
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subunit
ppp
cancer
gene
composition
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Pending
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CN202180039991.2A
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English (en)
Chinese (zh)
Inventor
肖恩·约斯特
斯蒂芬·哈里森
克里斯廷·泰勒·布鲁
迈克尔·大卫·温特
索拉布·班纳吉
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Anjin Biotechnology Private Ltd
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Anjin Biotechnology Private Ltd
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Publication of CN115769077A publication Critical patent/CN115769077A/zh
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/53751,4-Oxazines, e.g. morpholine
    • A61K31/53771,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088Compounds having three or more nucleosides or nucleotides
    • A61K31/713Double-stranded nucleic acids or oligonucleotides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14Hydrolases (3)
    • C12N9/16Hydrolases (3) acting on ester bonds (3.1)
    • C12N9/22Ribonucleases [RNase]; Deoxyribonucleases [DNase]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Microbiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
CN202180039991.2A 2020-04-01 2021-03-31 用于治疗癌症的方法和组合物 Pending CN115769077A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202063003736P 2020-04-01 2020-04-01
US63/003,736 2020-04-01
PCT/US2021/025230 WO2021202780A2 (en) 2020-04-01 2021-03-31 Methods and compositions for treating cancer

Publications (1)

Publication Number Publication Date
CN115769077A true CN115769077A (zh) 2023-03-07

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Family Applications (1)

Application Number Title Priority Date Filing Date
CN202180039991.2A Pending CN115769077A (zh) 2020-04-01 2021-03-31 用于治疗癌症的方法和组合物

Country Status (9)

Country Link
US (1) US20230149415A1 (https=)
EP (1) EP4127722A4 (https=)
JP (1) JP2023519931A (https=)
KR (1) KR20230017167A (https=)
CN (1) CN115769077A (https=)
AU (1) AU2021249111A1 (https=)
CA (1) CA3173799A1 (https=)
MX (1) MX2022012181A (https=)
WO (1) WO2021202780A2 (https=)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20240398799A1 (en) * 2021-08-19 2024-12-05 Engine Biosciences Pte. Ltd. Compositions and methods for generating synthetic lethality in tumors
WO2023177356A2 (en) * 2022-03-18 2023-09-21 Engine Biosciences Pte. Ltd. Compounds and method for pkmyt1 inhibition
KR20250136774A (ko) * 2024-03-08 2025-09-16 보로노이 주식회사 헤테로아릴 유도체 화합물 및 이의 용도
WO2025215187A1 (en) 2024-04-11 2025-10-16 My-T Bio Limited Therapeutic compounds and their use
WO2025215188A1 (en) 2024-04-11 2025-10-16 My-T Bio Limited Therapeutic compounds and their use as inhibitors of pkmyt1
WO2025242880A1 (en) 2024-05-24 2025-11-27 My-T Bio Limited Therapeutic compounds and their use
WO2026057597A1 (en) 2024-09-10 2026-03-19 My-T Bio Limited Pkmyt1 inhibitors and their use
WO2026057598A1 (en) 2024-09-10 2026-03-19 My-T Bio Limited Therapeutic compounds as pkmyt1 inhibitors and their use

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20090047675A1 (en) * 2007-05-01 2009-02-19 Dana-Farber Cancer Institute, Inc. Compositions and methods for indentifying transforming and tumor suppressor genes
US20160008361A1 (en) * 2012-11-28 2016-01-14 Merck Sharp & Dohme Corp. Compositions and methods for treating cancer
WO2016210134A1 (en) * 2015-06-23 2016-12-29 Case Western Reserve University Compositions and methods for treating cancer

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20090047675A1 (en) * 2007-05-01 2009-02-19 Dana-Farber Cancer Institute, Inc. Compositions and methods for indentifying transforming and tumor suppressor genes
US20160008361A1 (en) * 2012-11-28 2016-01-14 Merck Sharp & Dohme Corp. Compositions and methods for treating cancer
WO2016210134A1 (en) * 2015-06-23 2016-12-29 Case Western Reserve University Compositions and methods for treating cancer

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
GODFREY GRECH等: "Deregulation of the protein phosphatase 2A, PP2A in cancer: complexity and therapeutic options", TUMOR BIOLOGY, vol. 37, 21 July 2016 (2016-07-21), pages 11691 - 11700, XP036084812, DOI: 10.1007/s13277-016-5145-4 *
QINGYI ZHANG等: "Overexpressed PKMYT1 promotes tumor progression and associates with poor survival in esophageal squamous cell carcinoma", CANCER MANAGEMENT AND RESEARCH, vol. 11, 19 August 2019 (2019-08-19), pages 7813 - 7824, XP055870434, DOI: 10.2147/CMAR.S214243 *
潘耀振: "POU5F1B通过激活AKT,miR-660通过抑制PPP2R2A促进肝细胞癌的增殖", 中国优秀博士学位论文全文数据库, no. 01, 15 January 2019 (2019-01-15), pages 072 - 096 *

Also Published As

Publication number Publication date
WO2021202780A2 (en) 2021-10-07
EP4127722A4 (en) 2024-05-01
JP2023519931A (ja) 2023-05-15
US20230149415A1 (en) 2023-05-18
WO2021202780A3 (en) 2021-11-11
MX2022012181A (es) 2023-01-30
AU2021249111A1 (en) 2022-10-20
CA3173799A1 (en) 2021-10-07
EP4127722A2 (en) 2023-02-08
KR20230017167A (ko) 2023-02-03

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