CN115747026A

CN115747026A - Lung cancer circulating tumor cell detection device

Info

Publication number: CN115747026A
Application number: CN202211369708.5A
Authority: CN
Inventors: 王珂
Original assignee: Individual
Current assignee: Individual
Priority date: 2022-11-03
Filing date: 2022-11-03
Publication date: 2023-03-07

Abstract

The invention provides a lung cancer circulating tumor cell detection device, which relates to the field of medical instruments and comprises the following components: the rear side of the main body is provided with a connecting frame; a detection microscope is arranged on the connecting frame; a release rack is arranged in the main body and is of an arc-shaped structure; a trigger rack is also arranged in the main body; a switching motor is arranged on the left side inside the main body; the invention can automatically cancel the limiting work of the detected culture dish when the switching disc is rotated, is convenient for personnel to cancel the culture dish, and simultaneously limits the culture dish filled with the cells to be detected, can automatically realize the culture dish replacement only by rotating the switching disc, saves the steps of manually releasing the clamping structure and triggering the clamping structure, and solves the problem that the culture dish replacement work consumes longer time because the detection device needs trivial steps to cancel the limiting due to the arrangement of the limiting structure.

Description

Lung cancer circulating tumor cell detection device

Technical Field

The invention relates to the technical field of medical instruments, in particular to a lung cancer circulating tumor cell detection device.

Background

The lung cancer is a malignant tumor originated from a lung bronchial mucosa or a gland, the hematogenous spread is an important way for lung cancer metastasis, tumor cells can be metastasized at a remote place through blood circulation, and a detection device is needed for detecting the tumor cells.

When the existing detection device is used, the condition that a sample is lost due to accidental overturning of a culture dish in order to avoid detection is avoided, the limit structure can be arranged to limit the culture dish, but due to the arrangement of the limit structure, the limit is cancelled by trivial steps when the culture dish is replaced, the culture dish replacement work is long in time consumption, the detection efficiency of lung cancer circulating tumor cells is reduced, the existing detection device cannot automatically cancel the limit work of the detected culture dish when the culture dish is replaced, and similarly, the culture dish implementation limit of the pre-detection can not be automatically realized when the culture dish is replaced.

Disclosure of Invention

In view of this, the invention provides a lung cancer circulating tumor cell detection device, which solves the problem that when the existing detection device is used, in order to avoid the situation that a culture dish is accidentally tipped to cause sample loss during detection, a limit structure is arranged to limit the culture dish, but due to the arrangement of the limit structure, trivial steps are required to remove the limit when the culture dish is replaced, and the culture dish replacement work consumes a long time.

The invention provides a lung cancer circulating tumor cell detection device, which specifically comprises: the rear side of the main body is provided with a connecting frame; a detection microscope is arranged on the connecting frame; a release rack is arranged in the main body and is of an arc-shaped structure; a trigger rack is further arranged inside the main body and is of an arc-shaped structure; a switching motor is arranged on the left side inside the main body; a driving gear is arranged on an output shaft of the switching motor; a control module is arranged on the left side of the main body and is connected with a switching motor through a circuit; the central position in the main body is provided with an installation shaft; the installation epaxial switching dish that is provided with, and the switching dish is disc structure.

Furthermore, a follow-up toothed ring is arranged at the bottom of the switching disc and is of a circular ring structure.

Furthermore, the inner side of the clamping head is provided with a clamping pad, and the clamping pad is made of flexible materials.

Furthermore, the top of the inner side of the lifting piece is provided with a clamping shaft, and the clamping shaft is of a cylindrical structure.

Furthermore, an auxiliary bevel gear is arranged on the circumferential outer wall of the conversion shaft; the auxiliary bevel gear is meshed and connected with the main bevel gear.

Furthermore, the inner end of the clamping shaft is provided with a synchronizing wheel B, and the synchronizing wheel B is connected with the synchronizing wheel A through a synchronous belt.

Furthermore, a connector is arranged at the top end of the clamping column; the inner of connector is provided with presss from both sides tight head, and presss from both sides tight head and be disc structure.

Further, a mounting plate is arranged at the bottom of the inner side of the lifting piece; a transmission shaft is arranged at the inner end of the mounting plate; the transmission shaft is of a cylindrical structure.

Furthermore, a conversion shaft is arranged in the middle of the inner side of the lifting piece, and the conversion shaft is of a cylindrical structure; the inner end of the conversion shaft is provided with a synchronizing wheel A.

Further, the follow-up gear ring is meshed and connected with the driving gear; the top of the switching plate is arranged in a cross shape and provided with lifting pieces, and the top ends of the lifting pieces are of a disc-shaped structure.

Furthermore, a clamping screw rod is arranged on the circumferential outer wall of the clamping shaft, and the screw teeth of the two corresponding clamping screw rods are opposite; and the clamping screw rod is provided with a nut pair through a screw thread.

Furthermore, a transmission gear is arranged at the bottom of the transmission shaft, and when the transmission gear rotates to a certain position by taking the mounting shaft as a center, the transmission gear can be meshed with the trigger rack and the release rack in sequence; the top of the transmission shaft is provided with a main bevel gear.

Furthermore, a connecting piece is arranged on the nut pair; the top of the lifting piece is symmetrically arranged and provided with a stroke groove; a clamping column is arranged inside the stroke groove and is of a cylindrical structure; the bottom end of the clamping column is connected with the connecting piece.

Advantageous effects

(1) The invention drives the driving gear to rotate through the switching motor, so that the driving gear drives the switching disc to rotate under the action of meshing with the follow-up toothed ring, the switching disc drives the four lifting pieces and the four culture dishes provided with cells on the four lifting pieces to rotate anticlockwise, an appropriate transmission gear is meshed with the trigger rack in the rotation process, the transmission gear is influenced by the trigger rack to drive the transmission shaft and the main bevel gear to rotate, the main bevel gear drives the conversion shaft and the synchronizing wheel A to rotate under the action of meshing with the auxiliary bevel gear, the synchronizing wheel A drives the clamping shaft and the clamping screw rod under the action of connecting the synchronizing belt and the synchronizing wheel B, the clamping screw rod indirectly drives the clamping column, the clamping head and the clamping pad to move oppositely along the stroke groove by utilizing the opposite characteristics of screw teeth to be matched with the nut pair, the clamping pad limits the culture dishes from two sides, and avoids the phenomenon that the culture dishes are accidentally tipped under the influence of the outside in the detection process to cause the loss of sample cells to bring unnecessary troubles to the detection work.

(2) When the switching disc rotates, one transmission gear corresponding to the culture dish which is just detected is meshed with the releasing rack, so that the transmission gear drives the clamping structure of the device to reversely run under the action of matching with the releasing rack, the clamping structure is opened, the detected cell culture dish is conveniently taken down for processing, and time and labor are saved compared with manual dish taking.

(3) According to the invention, after the culture dish containing the lung cancer circulating tumor cells is placed at a proper position, the cells in the culture dish are detected through the detection microscope, so that the diseases can be detected in time and timely treatment can be carried out.

(4) According to the invention, when the switching disc is rotated, the limiting work of the detected culture dish can be automatically cancelled, so that the culture dish can be cancelled by personnel conveniently, and meanwhile, the culture dish filled with the cells to be detected is limited, so that the culture dish can be automatically replaced only by rotating the switching disc, the steps of manually removing a clamping structure and triggering the clamping structure are saved, the device has a clamping function, the detaching efficiency of the culture dish cannot be reduced due to the clamping function, and the inspection work of the lung cancer circulating tumor cells is indirectly improved.

Drawings

In order to more clearly illustrate the technical solutions of the embodiments of the present invention, the drawings of the embodiments will be briefly described below.

The drawings in the following description relate to some embodiments of the invention only and are not intended to limit the invention.

In the drawings:

fig. 1 is a schematic view of the overall structure of an embodiment of the present invention.

Fig. 2 is a schematic half-sectional structure of a switching plate according to an embodiment of the present invention.

Fig. 3 is a schematic diagram of an enlarged portion of a in fig. 2 according to an embodiment of the present invention.

Fig. 4 is a schematic diagram of a split structure of a switching disk according to an embodiment of the present invention.

Fig. 5 is a schematic bottom structure diagram of a switching tray of an embodiment of the present invention.

Fig. 6 is a schematic view of a clamping state structure of the clamping head of the embodiment of the invention.

FIG. 7 is a schematic structural view of the clamping head of an embodiment of the present invention in an unclamped state.

Fig. 8 is a schematic view of the clamping screw and the transmission gear according to the embodiment of the invention.

List of reference numerals

1. A main body; 101. a connecting frame; 102. detecting a microscope; 103. releasing the rack; 104. triggering the rack; 105. switching the motors; 106. a drive gear; 107. a control module; 2. installing a shaft; 3. a switching disc; 301. a follower ring gear; 302. a lifting piece; 303. mounting a plate; 304. a drive shaft; 305. a transmission gear; 306. a primary bevel gear; 307. a transfer shaft; 308. a synchronous wheel A; 309. a clamping shaft; 3010. a synchronous wheel B; 3011. clamping the screw rod; 3012. a nut pair; 3013. a connecting member; 3014. a stroke slot; 3015. clamping the column; 3016. a connector; 3017. a clamping head; 3018. a clamping pad; 3019. and a secondary bevel gear.

Detailed Description

In order to make the objects, solutions and advantages of the technical solutions of the present invention clearer, the technical solutions of the embodiments of the present invention will be clearly and completely described below with reference to the accompanying drawings of specific embodiments of the present invention. Unless otherwise indicated, terms used herein have the ordinary meaning in the art. Like reference numerals in the drawings denote like elements.

Example (b): please refer to fig. 1 to 8:

the invention provides a lung cancer circulating tumor cell detection device, comprising: a main body 1, wherein a connecting frame 101 is arranged at the rear side of the main body 1; the connecting frame 101 is provided with a detection microscope 102, and the detection microscope 102 can detect the cells in the culture dish; a release rack 103 is arranged in the main body 1, and the release rack 103 is of an arc-shaped structure; a trigger rack 104 is further arranged inside the main body 1, and the trigger rack 104 is of an arc-shaped structure; a switching motor 105 is provided at the left side of the inside of the main body 1; a driving gear 106 is arranged on an output shaft of the switching motor 105; a control module 107 is arranged on the left side of the main body 1, and the control module 107 is connected with the switching motor 105 through a line; the central position in the main body 1 is provided with an installation shaft 2; a switching disc 3 is arranged on the mounting shaft 2, and the switching disc 3 is of a disc-shaped structure;

the switching motor 105 drives the driving gear 106 to rotate, so that the driving gear is meshed with the following gear ring 301 to drive the switching disc 3 to rotate, the switching disc 3 drives the four lifting pieces 302 and the four culture dishes containing cells thereon to rotate anticlockwise, and power is provided for culture dish switching work.

Wherein, the bottom of the switching plate 3 is provided with a following toothed ring 301, and the following toothed ring 301 is of a circular structure; the following gear ring 301 is meshed and connected with the driving gear 106; lifting pieces 302 are arranged on the top of the switching plate 3 in a cross shape, and the top ends of the lifting pieces 302 are in a disc-shaped structure; the bottom of the inner side of the lifting piece 302 is provided with a mounting plate 303; the inner end of the mounting plate 303 is provided with a transmission shaft 304; the transmission shaft 304 is a cylindrical structure; the bottom of the transmission shaft 304 is provided with a transmission gear 305, and when the transmission gear 305 rotates to a certain position by taking the mounting shaft 2 as a center, the transmission gear 305 is meshed with the trigger rack 104 and the release rack 103 in sequence; the top of the transmission shaft 304 is provided with a main bevel gear 306; a conversion shaft 307 is arranged at the central position of the inner side of the lifting piece 302, and the conversion shaft 307 is of a cylindrical structure; the inner end of the conversion shaft 307 is provided with a synchronous wheel A308; the top of the inner side of the lifting piece 302 is provided with a clamping shaft 309, and the clamping shaft 309 is of a cylindrical structure; a synchronizing wheel B3010 is arranged at the inner end of the clamping shaft 309, and the synchronizing wheel B3010 is connected with the synchronizing wheel A308 through a synchronizing belt; a clamping screw rod 3011 is arranged on the circumferential outer wall of the clamping shaft 309, and the screw teeth of the two corresponding clamping screw rods 3011 are opposite; a nut pair 3012 is arranged on the clamping screw rod 3011 through a screw thread; the nut pair 3012 is provided with a connecting piece 3013; the top of the lifting piece 302 is symmetrically provided with a stroke slot 3014; a clamping post 3015 is arranged inside the stroke slot 3014, and the clamping post 3015 is of a cylindrical structure; the bottom ends of the clamping posts 3015 are connected with the connecting pieces 3013; the top end of the clamping post 3015 is provided with a connector 3016; a clamping head 3017 is arranged at the inner end of the connecting head 3016, and the clamping head 3017 is in a disc-shaped structure; a clamping pad 3018 is arranged on the inner side of the clamping head 3017, and the clamping pad 3018 is made of flexible material; an auxiliary bevel gear 3019 is arranged on the circumferential outer wall of the conversion shaft 307; the secondary bevel gear 3019 is in meshing connection with the primary bevel gear 306;

in the process of rotating the switching disc 3, one transmission gear 305 corresponding to a pre-detection culture dish is meshed with the trigger rack 104, so that the transmission gear 305 is influenced by the trigger rack 104 to drive the transmission shaft 304 and the main bevel gear 306 to rotate, the main bevel gear 306 drives the conversion shaft 307 and the synchronizing wheel A308 to rotate under the action of meshing with the auxiliary bevel gear 3019, the synchronizing wheel A308 drives the clamping shaft 309 and the clamping screw 3011 under the action of connecting with the synchronizing wheel B3010 through a synchronous belt, the clamping screw 3011 indirectly drives the clamping column 3015, the clamping head 3017 and the clamping pad 3018 to move inwards relatively along the stroke slot 3014 by utilizing the opposite characteristics of screw teeth and matching with the nut pair 3012, so that the clamping pad 3018 limits the culture dish from two sides, and simultaneously, the transmission gear 305 corresponding to the culture dish which has just detected is completely detected is meshed with the release rack 103, so that the transmission gear 305 drives the clamping structure of the device to reversely run under the action of matching with the release rack 103, thereby opening the clamping structure and facilitating a detection person to take out the tumor cells which have been detected under the circulation dish; the clamping pads 3018 are provided to prevent the clamping structure in the device from damaging the glass culture dish during clamping;

in another embodiment: when the culture dish adopted in the detection is made of plastic materials, the clamping pad 3018 can be omitted, and therefore the production cost of the device can be reduced.

The specific use mode and function of the embodiment are as follows: when the device is used, the control module 107 is controlled to start the switching motor 105, the switching motor 105 drives the driving gear 106 to rotate, the switching disc 3 is driven to rotate under the action of meshing with the follow-up toothed ring 301, the switching disc 3 drives the four lifting pieces 302 and the four culture dishes provided with cells thereon to rotate anticlockwise, in the rotation process of the switching disc 3, one transmission gear 305 corresponding to a pre-detection culture dish is meshed with the trigger rack 104, the transmission gear 305 is influenced by the trigger rack 104 to drive the transmission shaft 304 and the main bevel gear 306 to rotate, the main bevel gear 306 drives the conversion shaft 307 and the synchronizing wheel A308 to rotate under the action of meshing with the auxiliary bevel gear 3019, the synchronizing wheel A308 drives the clamping shaft 309 and the clamping screw rod 3011 under the action of connecting with the synchronizing wheel B3010 through the synchronous belt, the clamping screw rod 3011 is matched with the nut pair 3012 by using the opposite characteristics of screw teeth to indirectly drive the clamping column 3015, the clamping head 3017 and the clamping pad 3018 to move inwards along the stroke slot 3014, the clamping pad 3018 is driven to perform the detection on the lung cancer cell culture dish from the clamping rack 102, and the microscope 102 under the detection, and the detection of the lung cancer cell culture dish is performed by the microscope.

Finally, it should be noted that, when describing the positions of the components and the matching relationship between the components, the invention will be generally exemplified by one/a pair of components, however, it should be understood by those skilled in the art that such positions, matching relationship, etc. are also applicable to other components/other pairs of components.

The above description is intended to be illustrative of the present invention and not to limit the scope of the invention, which is defined by the claims appended hereto.

Claims

1. Lung cancer circulating tumor cell detection device, characterized by, includes: the device comprises a main body (1), wherein a connecting frame (101) is arranged on the rear side of the main body (1); a detection microscope (102) is arranged on the connecting frame (101); a release rack (103) is arranged in the main body (1), and the release rack (103) is of an arc-shaped structure; a trigger rack (104) is further arranged inside the main body (1), and the trigger rack (104) is of an arc-shaped structure; a switching motor (105) is arranged on the left side in the main body (1); a driving gear (106) is arranged on an output shaft of the switching motor (105); a control module (107) is arranged on the left side of the main body (1), and the control module (107) is connected with a switching motor (105) through a line; an installation shaft (2) is arranged in the central position in the main body (1); the mounting shaft (2) is provided with a switching disc (3), and the switching disc (3) is of a disc-shaped structure.

2. The apparatus for detecting circulating tumor cells of lung cancer according to claim 1, wherein: a follow-up toothed ring (301) is arranged at the bottom of the switching disc (3), and the follow-up toothed ring (301) is of a circular structure; the follow-up gear ring (301) is meshed and connected with the driving gear (106); the top of the switching plate (3) is provided with lifting pieces (302) in a cross arrangement, and the top ends of the lifting pieces (302) are of a disc-shaped structure.

3. The apparatus for detecting circulating tumor cells of lung cancer according to claim 2, wherein: the bottom of the inner side of the lifting piece (302) is provided with a mounting plate (303); a transmission shaft (304) is arranged at the inner end of the mounting plate (303); the drive shaft (304) is of a cylindrical configuration.

4. The apparatus for detecting circulating tumor cells of lung cancer according to claim 3, wherein: the bottom of the transmission shaft (304) is provided with a transmission gear (305), and when the transmission gear (305) rotates to a certain position by taking the mounting shaft (2) as a center, the transmission gear can be meshed with the trigger rack (104) and the release rack (103) in sequence; the top of the transmission shaft (304) is provided with a main bevel gear (306).

5. The apparatus for detecting circulating tumor cells of lung cancer according to claim 4, wherein: a conversion shaft (307) is arranged at the central position of the inner side of the lifting piece (302), and the conversion shaft (307) is of a cylindrical structure; the inner end of the conversion shaft (307) is provided with a synchronous wheel A (308).

6. The apparatus for detecting circulating tumor cells of lung cancer according to claim 5, wherein: the top of the inner side of the lifting piece (302) is provided with a clamping shaft (309), and the clamping shaft (309) is of a cylindrical structure; the inner end of the clamping shaft (309) is provided with a synchronizing wheel B (3010), and the synchronizing wheel B (3010) is connected with the synchronizing wheel A (308) through a synchronizing belt.

7. The apparatus for detecting circulating tumor cells of lung cancer according to claim 6, wherein: a clamping screw rod (3011) is arranged on the circumferential outer wall of the clamping shaft (309), and the screw teeth of the two corresponding clamping screw rods (3011) are opposite; and a nut pair (3012) is arranged on the clamping screw rod (3011) through a screw thread.

8. The apparatus for detecting circulating tumor cells of lung cancer according to claim 7, wherein: a connecting piece (3013) is arranged on the nut pair (3012); the top of the lifting piece (302) is symmetrically provided with a stroke slot (3014); a clamping column (3015) is arranged inside the stroke slot (3014), and the clamping column (3015) is of a cylindrical structure; the bottom ends of the clamping columns (3015) are connected with the connecting pieces (3013).

9. The apparatus for detecting circulating tumor cells of lung cancer according to claim 8, wherein: the top end of the clamping column (3015) is provided with a connector (3016); the inner end of the connecting head (3016) is provided with a clamping head (3017), and the clamping head (3017) is of a disc-shaped structure.

10. The apparatus for detecting circulating tumor cells of lung cancer according to claim 9, wherein: a clamping pad (3018) is arranged on the inner side of the clamping head (3017), and the clamping pad (3018) is made of flexible materials; an auxiliary bevel gear (3019) is arranged on the circumferential outer wall of the conversion shaft (307); the auxiliary bevel gear (3019) is meshed with the main bevel gear (306).