CN1157183C - Calamine lotion - Google Patents
Calamine lotion Download PDFInfo
- Publication number
- CN1157183C CN1157183C CNB011414146A CN01141414A CN1157183C CN 1157183 C CN1157183 C CN 1157183C CN B011414146 A CNB011414146 A CN B011414146A CN 01141414 A CN01141414 A CN 01141414A CN 1157183 C CN1157183 C CN 1157183C
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- China
- Prior art keywords
- calamine lotion
- lotion
- xanthan gum
- calamine
- preparation
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Abstract
The present invention relates to a calamine lotion which is characterized in that the calamine lotion contains Xanthan gum. The xanthan gum is used as an additive of the calamine lotion and makes the stability of the calamine lotion favorable; the xanthan gum feels smooth; after being coated and dried, the calamine lotion is not easy to desquamate.
Description
The present invention relates to a kind of stable Calamine Lotion.
Calamina (Calamine) has another name called calamine, is carbonate mineral calcite family smithsonite, the main zinc carbonate (ZnCO that contains
3).This product is block aggregation, is irregular bulk, canescence or pale red.Calamina is Chinese Chinese medicine, and the detoxifcation improving acuity of vision and removing nebula is arranged, and the antipruritic effect of holding back skin ulcer of removing dampness is the China national essential drugs, clinical Calamine Lotion commonly used.
Calamine Lotion (Calamine Lotion) is a kind of external suspensoid, and Calamina commonly used and zinc oxide prescription add additives such as wetting agent glycerol, adds to obtain after water grinds.According to clinical demand, product uses after also can diluting certain multiple.Calamine Lotion is often prepared by hospital pharmacy, " hospital preparation " (Hunan science tech publishing house, 1980), " Chinese Hospitals preparation standard " (Chinese Medicine science and technology publishing house, 1995) and " practical hospital preparation note " (People's Health Publisher, 1997) all record the prescription and the preparation method of Calamine Lotion.The former prescription is made up of Calamina, zinc oxide, glycerol, polysorbas20, water; The latter two are made up of Calamina, zinc oxide, glycerol, sodium carboxymethyl cellulose and water.All there are some problems in their prescription and preparation method in practical operation, bad as lotion stability, sedimentation is fast, and easily caking is difficult to redispersion, and dust is more during preparation.In addition, hospital preparation section office generally once prepare 10,000 milliliters or more Calamine Lotion, because Calamine Lotion sedimentation in container of tradition prescription preparation is very fast, in the time of in it being dispensed to 10 milliliters of bottles, the container that 10,000 milliliters or more lotions must strong jolting be housed, it is disperseed after again row distribute.This operation is effort very often, and because the lotion sedimentation is very fast and may lump, and makes the dispersion may be inhomogeneous.The lotion of the small bottle packing that the patient uses also can run into same problem.Therefore demand urgently finding a kind of Calamine Lotion that makes stable or a little sedimentation is arranged but method that slight jolting gets final product.
The present invention has been surprisingly found out that adding xanthan gum in Calamine Lotion makes its traditional prescription highly stable, and the feel exquisiteness, the dry back of coating difficult drop-off.
Xanthan gum (Xamthan gum) is to be the outer polyanion heteropolysaccharide of a kind of born of the same parents of substrate fermentation generation with the carbohydrate by the Xanthomonas campestris microorganism belonging to genus.It is a kind of existence protective substance that evolution that microorganism has been experienced millions of years produces, and has the incomparable unusual physicochemical property of other natural gum (mainly referring to plant gum).Xanthan gum physicochemical property characteristics comprise: viscosity is constant in 0～100 ℃ of scope; The low concentration xanthan gum can produce viscosity higher; In extremely wide shear rate and concentration range, keep high vacation to mould thixotropy; Splendid heat stability; Under strong acid and highly basic condition, has solubility and stability; All has compatibility and stability with most slaine; Good with the compatibility of the solvent of using always, reagent.
Characteristics of the present invention are to adopt the additive of xanthan gum as Calamine Lotion.Xanthan gum is that thixotropy is moulded in its vacation in the outstanding feature as the suspending agent of Calamine Lotion.The latter is meant that sol solution has very high viscosity or forms gel at resting state, and viscosity reduces easy flowing rapidly under extraneous mechanical force (jolting or stirring) effect.After the swelling, basic framework like fibrous element forms double-helical club shaped structure to xanthan gum in aqueous solution, and is comparatively stable when leaving standstill, and the suspended matter stable support can be had the effect of similar " skeleton "; When extraneous shearing force increases, change linear structure at once into, viscosity reduces, and has good flowability.Therefore xanthan gum can obviously increase the physical stability of Calamine Lotion, is distributing and is easily toppling over during coating and smear again.The viscosity that xanthan gum is stronger makes Calamine Lotion easily spread on skin, and sensation is fine and smooth, easily eccysis, and also medicine is difficult for coming off from skin behind the moisture evaporation, has improved Calamine Lotion bioavailability and medication comfort.
Be used for xanthan gum of the present invention and should be about 500～1200 centipoises in the viscosity of 1% aqueous solution.This is with NOJ-1 type rotary viscosimeter, 60rpm, and No. 2 rotors are measured and are obtained.
When the present invention prepares at Calamine Lotion, generally with the aqueous solution of xanthan gum as disperse medium, wherein can contain other water-soluble additive or other medicines.The concentration of xanthan gum in aqueous solution can be 0.05～8g/100ml, and 0.1～5g/100ml preferably is more preferably at 0.2～2g/100ml.The content of xanthan gum in Calamine Lotion can be in 0.01～5% (w/w) scope.Other additive in the aqueous dispersion medium can comprise flocculating agent, as sodium citrate; Wetting agent, as glycerol, propylene glycol, sorbitol; Surfactant is as Polysorbate; Aromatic is as various essence.Decentralized photo is generally Calamina and zinc oxide, can also comprise the other medicines that are selected from phenol, menthol, Camphora and sulfur, but be not limited thereto.
The suspensoid preparation method that Calamine Lotion preparation technology among the present invention can adopt this area professional person to use always.Suspensoid preparation technology commonly used records in various pharmaceutics monographs, be the general technical ability that this professional field should be grasped, mainly comprise and treat that dispersed substance adds aqueous solution or additive is ground to certain fineness, restock adds all the other aqueous solutions and additive, and sieving after being ground to a certain degree obtains.Utilize mechanically actuated such as the colloid mill can be simpler.
The Calamine Lotion good stability that obtains among the present invention, feel exquisiteness, dry back difficult drop-off.
Embodiment: Calamine Lotion preparation
Calamina 15g
Zinc oxide 5g
Glycerol 5ml
Xanthan gum 0.5g
Distilled water adds to 100ml
Getting 120 order Calaminas and 120 order zinc oxide mixes roughly in mortar, other gets glycerol 5ml adding 20ml water wiring solution-forming and adds in the above-mentioned solid mixture, grind to form pasty state, add 1% xanthan gum solution 50ml gradually, and constantly grind, last supplementing water obtains homodisperse pale red suspension to 100ml.This suspension particle 90% is less than 40 microns.Comparing embodiment: the Calamine Lotion that does not contain xanthan gum
Table 1 does not contain the prescription of calamine Lotion of xanthan gum
The composition prescription
F
1 F
2 F
3
Calamina 15g 15g 15g
Zinc oxide 5g 5g 5g
Glycerol 5ml 5ml 5ml
Distilled water 100ml 100ml 100ml
Guar gum-0.2g-
Arabic gum--2g
Method for making is with above-mentioned embodiment.
The lotion (embodiment) that contains xanthan gum is applied to feels fine and smooth, dry back difficult drop-off on the skin; And the lotion (F of traditional hospital prescription
1) more coarse, easily come off after the drying.The comparative result of comparing embodiment and embodiment sees Table 2.The lotion (embodiment) that contains xanthan gum is placed the lotion of sedimentation velocity much smaller than other suspending agent of independent usefulness such as sodium carboxymethyl cellulose or arabic gum preparation.The embodiment lotion was placed after 2 years, hand vibration, and redispersible in 1 minute is even suspension.
The sedimentation volumn ratio of the different prescription of table 2 Calamine Lotion
The time of repose sedimentation volumn is than (%)
F
1F
2F
3Embodiment
12 hours 58 85 81 95
1 day 29 38 30 92
2 days 28 32 28 91
1 week＜10% no longer changes
1.29＜10% no longer change
1.74
2.
Illustrate: 1. dispersibility is bad again; 2. disperse more again.
Claims (3)
1. stable Calamine Lotion is characterized in that containing the xanthan gum of 0.01～5% (w/w).
2. as the Calamine Lotion in the claim 1, also contain other medicines, be selected from phenol, menthol, Camphora and sulfur.
3. as the Calamine Lotion in the claim 1, also contain wetting agent, flocculating agent, surfactant and aromatic.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB011414146A CN1157183C (en) | 2001-09-24 | 2001-09-24 | Calamine lotion |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB011414146A CN1157183C (en) | 2001-09-24 | 2001-09-24 | Calamine lotion |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1337226A CN1337226A (en) | 2002-02-27 |
| CN1157183C true CN1157183C (en) | 2004-07-14 |
Family
ID=4676152
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNB011414146A Expired - Fee Related CN1157183C (en) | 2001-09-24 | 2001-09-24 | Calamine lotion |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1157183C (en) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104189004B (en) * | 2014-09-04 | 2016-08-17 | 湖南尔康湘药制药有限公司 | A kind of production method of Calamine Lotion |
| CN104940137B (en) * | 2015-06-02 | 2019-03-01 | 湖南尔康制药股份有限公司 | A kind of preparation method of calamine lotion |
| CN108210455A (en) * | 2016-12-19 | 2018-06-29 | 湖南尔康湘药制药有限公司 | A kind of zinc carbonate nano-micelle preparations and preparation method |
| CN111135115B (en) * | 2018-11-06 | 2023-10-17 | 上海家化联合股份有限公司 | Calamine-containing composition |
| CN109674750A (en) * | 2019-01-29 | 2019-04-26 | 江苏鹏鹞药业有限公司 | A kind of calamine lotion with bacteriostasis |
-
2001
- 2001-09-24 CN CNB011414146A patent/CN1157183C/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| CN1337226A (en) | 2002-02-27 |
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