CN109674750A - A kind of calamine lotion with bacteriostasis - Google Patents
A kind of calamine lotion with bacteriostasis Download PDFInfo
- Publication number
- CN109674750A CN109674750A CN201910085264.4A CN201910085264A CN109674750A CN 109674750 A CN109674750 A CN 109674750A CN 201910085264 A CN201910085264 A CN 201910085264A CN 109674750 A CN109674750 A CN 109674750A
- Authority
- CN
- China
- Prior art keywords
- parts
- calamine
- added
- lotion
- zinc oxide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- CPYIZQLXMGRKSW-UHFFFAOYSA-N zinc;iron(3+);oxygen(2-) Chemical compound [O-2].[O-2].[O-2].[O-2].[Fe+3].[Fe+3].[Zn+2] CPYIZQLXMGRKSW-UHFFFAOYSA-N 0.000 title claims abstract description 105
- 239000008338 calamine lotion Substances 0.000 title claims abstract description 42
- 239000011787 zinc oxide Substances 0.000 claims abstract description 90
- 235000014692 zinc oxide Nutrition 0.000 claims abstract description 90
- XLOMVQKBTHCTTD-UHFFFAOYSA-N Zinc monoxide Chemical compound [Zn]=O XLOMVQKBTHCTTD-UHFFFAOYSA-N 0.000 claims abstract description 88
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 53
- 229940105847 calamine Drugs 0.000 claims abstract description 46
- 229910052864 hemimorphite Inorganic materials 0.000 claims abstract description 46
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims abstract description 45
- 239000008213 purified water Substances 0.000 claims abstract description 35
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 claims abstract description 27
- 230000003115 biocidal effect Effects 0.000 claims abstract description 26
- 239000001768 carboxy methyl cellulose Substances 0.000 claims abstract description 24
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 claims abstract description 21
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 claims abstract description 21
- ISWSIDIOOBJBQZ-UHFFFAOYSA-N Phenol Chemical compound OC1=CC=CC=C1 ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 claims abstract description 16
- 238000002360 preparation method Methods 0.000 claims abstract description 14
- 239000000725 suspension Substances 0.000 claims abstract description 11
- 239000002994 raw material Substances 0.000 claims abstract description 7
- 238000003756 stirring Methods 0.000 claims description 30
- 239000000084 colloidal system Substances 0.000 claims description 20
- 238000000034 method Methods 0.000 claims description 18
- OTVAEFIXJLOWRX-NXEZZACHSA-N thiamphenicol Chemical compound CS(=O)(=O)C1=CC=C([C@@H](O)[C@@H](CO)NC(=O)C(Cl)Cl)C=C1 OTVAEFIXJLOWRX-NXEZZACHSA-N 0.000 claims description 16
- 229960003053 thiamphenicol Drugs 0.000 claims description 16
- 239000000203 mixture Substances 0.000 claims description 15
- 229920000858 Cyclodextrin Polymers 0.000 claims description 14
- 239000001116 FEMA 4028 Substances 0.000 claims description 14
- WHGYBXFWUBPSRW-FOUAGVGXSA-N beta-cyclodextrin Chemical compound OC[C@H]([C@H]([C@@H]([C@H]1O)O)O[C@H]2O[C@@H]([C@@H](O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O3)[C@H](O)[C@H]2O)CO)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@@H]3O[C@@H]1CO WHGYBXFWUBPSRW-FOUAGVGXSA-N 0.000 claims description 14
- 235000011175 beta-cyclodextrine Nutrition 0.000 claims description 14
- 229960004853 betadex Drugs 0.000 claims description 14
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 12
- OFOBLEOULBTSOW-UHFFFAOYSA-N Malonic acid Chemical compound OC(=O)CC(O)=O OFOBLEOULBTSOW-UHFFFAOYSA-N 0.000 claims description 10
- 239000007788 liquid Substances 0.000 claims description 10
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 claims description 9
- IDGUHHHQCWSQLU-UHFFFAOYSA-N ethanol;hydrate Chemical compound O.CCO IDGUHHHQCWSQLU-UHFFFAOYSA-N 0.000 claims description 9
- 239000000843 powder Substances 0.000 claims description 8
- 235000009508 confectionery Nutrition 0.000 claims description 7
- 239000003292 glue Substances 0.000 claims description 7
- 238000000227 grinding Methods 0.000 claims description 7
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims description 6
- 229920003123 carboxymethyl cellulose sodium Polymers 0.000 claims description 6
- 229940063834 carboxymethylcellulose sodium Drugs 0.000 claims description 6
- 239000008367 deionised water Substances 0.000 claims description 6
- 229910021641 deionized water Inorganic materials 0.000 claims description 6
- 238000002156 mixing Methods 0.000 claims description 6
- 239000002002 slurry Substances 0.000 claims description 6
- 229910052708 sodium Inorganic materials 0.000 claims description 6
- 239000011734 sodium Substances 0.000 claims description 6
- GCLGEJMYGQKIIW-UHFFFAOYSA-H sodium hexametaphosphate Chemical compound [Na]OP1(=O)OP(=O)(O[Na])OP(=O)(O[Na])OP(=O)(O[Na])OP(=O)(O[Na])OP(=O)(O[Na])O1 GCLGEJMYGQKIIW-UHFFFAOYSA-H 0.000 claims description 6
- 239000007787 solid Substances 0.000 claims description 6
- 238000010792 warming Methods 0.000 claims description 6
- 239000004575 stone Substances 0.000 claims description 4
- 238000005406 washing Methods 0.000 claims description 4
- 229920002134 Carboxymethyl cellulose Polymers 0.000 claims description 3
- UEZVMMHDMIWARA-UHFFFAOYSA-N Metaphosphoric acid Chemical compound OP(=O)=O UEZVMMHDMIWARA-UHFFFAOYSA-N 0.000 claims description 3
- 235000010948 carboxy methyl cellulose Nutrition 0.000 claims description 3
- 239000008112 carboxymethyl-cellulose Substances 0.000 claims description 3
- 229940105329 carboxymethylcellulose Drugs 0.000 claims description 3
- 229960000935 dehydrated alcohol Drugs 0.000 claims description 3
- 239000012153 distilled water Substances 0.000 claims description 3
- 238000001035 drying Methods 0.000 claims description 3
- 229960004756 ethanol Drugs 0.000 claims description 3
- 238000003760 magnetic stirring Methods 0.000 claims description 3
- 239000003595 mist Substances 0.000 claims description 3
- 238000007789 sealing Methods 0.000 claims description 3
- 235000019982 sodium hexametaphosphate Nutrition 0.000 claims description 3
- 238000005507 spraying Methods 0.000 claims description 3
- 239000001577 tetrasodium phosphonato phosphate Substances 0.000 claims description 3
- RNWHGQJWIACOKP-UHFFFAOYSA-N zinc;oxygen(2-) Chemical class [O-2].[Zn+2] RNWHGQJWIACOKP-UHFFFAOYSA-N 0.000 claims description 3
- 244000246386 Mentha pulegium Species 0.000 claims 1
- 235000016257 Mentha pulegium Nutrition 0.000 claims 1
- 235000004357 Mentha x piperita Nutrition 0.000 claims 1
- 210000004556 brain Anatomy 0.000 claims 1
- 235000001050 hortel pimenta Nutrition 0.000 claims 1
- 239000006210 lotion Substances 0.000 abstract description 31
- 230000000844 anti-bacterial effect Effects 0.000 abstract description 9
- 208000003251 Pruritus Diseases 0.000 abstract description 8
- NOOLISFMXDJSKH-UTLUCORTSA-N (+)-Neomenthol Chemical compound CC(C)[C@@H]1CC[C@@H](C)C[C@@H]1O NOOLISFMXDJSKH-UTLUCORTSA-N 0.000 abstract description 7
- NOOLISFMXDJSKH-UHFFFAOYSA-N DL-menthol Natural products CC(C)C1CCC(C)CC1O NOOLISFMXDJSKH-UHFFFAOYSA-N 0.000 abstract description 7
- 229940041616 menthol Drugs 0.000 abstract description 7
- 238000005260 corrosion Methods 0.000 abstract description 4
- 230000001766 physiological effect Effects 0.000 abstract description 3
- 230000001954 sterilising effect Effects 0.000 abstract description 3
- 238000004659 sterilization and disinfection Methods 0.000 abstract description 3
- 239000000375 suspending agent Substances 0.000 abstract description 3
- 239000000243 solution Substances 0.000 description 33
- 239000002245 particle Substances 0.000 description 20
- 230000003110 anti-inflammatory effect Effects 0.000 description 6
- CEAZRRDELHUEMR-URQXQFDESA-N Gentamicin Chemical compound O1[C@H](C(C)NC)CC[C@@H](N)[C@H]1O[C@H]1[C@H](O)[C@@H](O[C@@H]2[C@@H]([C@@H](NC)[C@@](C)(O)CO2)O)[C@H](N)C[C@@H]1N CEAZRRDELHUEMR-URQXQFDESA-N 0.000 description 5
- 229930182566 Gentamicin Natural products 0.000 description 5
- 230000000694 effects Effects 0.000 description 5
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 5
- 239000010410 layer Substances 0.000 description 5
- 241000894006 Bacteria Species 0.000 description 4
- 229910019142 PO4 Inorganic materials 0.000 description 4
- 230000015572 biosynthetic process Effects 0.000 description 4
- 239000003795 chemical substances by application Substances 0.000 description 4
- 229960002518 gentamicin Drugs 0.000 description 4
- 238000002955 isolation Methods 0.000 description 4
- 239000010452 phosphate Substances 0.000 description 4
- 230000003335 steric effect Effects 0.000 description 4
- 240000002657 Thymus vulgaris Species 0.000 description 3
- 235000007303 Thymus vulgaris Nutrition 0.000 description 3
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 description 3
- 150000001875 compounds Chemical class 0.000 description 3
- 239000006185 dispersion Substances 0.000 description 3
- 239000000463 material Substances 0.000 description 3
- 230000003647 oxidation Effects 0.000 description 3
- 238000007254 oxidation reaction Methods 0.000 description 3
- 239000001585 thymus vulgaris Substances 0.000 description 3
- 239000011701 zinc Substances 0.000 description 3
- 229910052725 zinc Inorganic materials 0.000 description 3
- 239000002253 acid Substances 0.000 description 2
- 230000001154 acute effect Effects 0.000 description 2
- 239000012670 alkaline solution Substances 0.000 description 2
- 230000001139 anti-pruritic effect Effects 0.000 description 2
- 239000003908 antipruritic agent Substances 0.000 description 2
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 2
- 235000013339 cereals Nutrition 0.000 description 2
- 239000013078 crystal Substances 0.000 description 2
- 239000002270 dispersing agent Substances 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 230000002708 enhancing effect Effects 0.000 description 2
- 230000032050 esterification Effects 0.000 description 2
- 238000005886 esterification reaction Methods 0.000 description 2
- 230000036571 hydration Effects 0.000 description 2
- 238000006703 hydration reaction Methods 0.000 description 2
- 230000002209 hydrophobic effect Effects 0.000 description 2
- 239000013618 particulate matter Substances 0.000 description 2
- UEZVMMHDMIWARA-UHFFFAOYSA-M phosphonate Chemical compound [O-]P(=O)=O UEZVMMHDMIWARA-UHFFFAOYSA-M 0.000 description 2
- 239000011148 porous material Substances 0.000 description 2
- 230000001681 protective effect Effects 0.000 description 2
- 230000001823 pruritic effect Effects 0.000 description 2
- 208000017520 skin disease Diseases 0.000 description 2
- 239000002689 soil Substances 0.000 description 2
- 230000001629 suppression Effects 0.000 description 2
- 206010002198 Anaphylactic reaction Diseases 0.000 description 1
- 201000004624 Dermatitis Diseases 0.000 description 1
- 241000588724 Escherichia coli Species 0.000 description 1
- 206010027627 Miliaria Diseases 0.000 description 1
- 240000007594 Oryza sativa Species 0.000 description 1
- 235000007164 Oryza sativa Nutrition 0.000 description 1
- 241000191967 Staphylococcus aureus Species 0.000 description 1
- 208000024780 Urticaria Diseases 0.000 description 1
- 241000726445 Viroids Species 0.000 description 1
- 230000036783 anaphylactic response Effects 0.000 description 1
- 208000003455 anaphylaxis Diseases 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 230000000536 complexating effect Effects 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 238000006073 displacement reaction Methods 0.000 description 1
- 230000001804 emulsifying effect Effects 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- OUUQCZGPVNCOIJ-UHFFFAOYSA-N hydroperoxyl Chemical compound O[O] OUUQCZGPVNCOIJ-UHFFFAOYSA-N 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 230000005764 inhibitory process Effects 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 230000002147 killing effect Effects 0.000 description 1
- 201000004169 miliaria rubra Diseases 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 239000002105 nanoparticle Substances 0.000 description 1
- 238000011056 performance test Methods 0.000 description 1
- 230000000704 physical effect Effects 0.000 description 1
- 239000002574 poison Substances 0.000 description 1
- 231100000614 poison Toxicity 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 235000009566 rice Nutrition 0.000 description 1
- 238000010008 shearing Methods 0.000 description 1
- 239000002344 surface layer Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
- A61K33/30—Zinc; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
- A61K31/05—Phenols
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61K47/38—Cellulose; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
- A61K47/6949—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes
- A61K47/6951—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes using cyclodextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/04—Antipruritics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/02—Local antiseptics
-
- C—CHEMISTRY; METALLURGY
- C01—INORGANIC CHEMISTRY
- C01G—COMPOUNDS CONTAINING METALS NOT COVERED BY SUBCLASSES C01D OR C01F
- C01G9/00—Compounds of zinc
-
- C—CHEMISTRY; METALLURGY
- C01—INORGANIC CHEMISTRY
- C01G—COMPOUNDS CONTAINING METALS NOT COVERED BY SUBCLASSES C01D OR C01F
- C01G9/00—Compounds of zinc
- C01G9/02—Oxides; Hydroxides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Inorganic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Dermatology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Dispersion Chemistry (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The invention discloses a kind of calamine lotions with bacteriostasis, are made of the raw material of following parts by weight: modified calamine 140-160 parts, 45-55 parts of zinc oxide, 5-7 parts of modified nano zinc oxide, phenol 8-10 parts medicinal, 6-8 parts of antibiotic, 10-12 parts of menthol, 20-26 parts of polysorbas20,7-10 parts of glycerol, 2-3 parts of sodium carboxymethylcellulose, 800-900 parts of purified water.For the present invention to be modified calamine, zinc oxide as the principle active component of lotion, the antibacterial of the two, convergence, anti-corrosion and itching-relieving efficacies are strong；By the way that modified nano zinc oxide is added in right amount, assign lotion excellent bacteriostasis property；Medicinal phenol is able to extend the term of validity that preparation uses, and increases preparation stability, enhances its sterilization, antibacterial, itching-relieving action；Furthermore in the preparation process of calamine lotion, sodium carboxymethylcellulose suspending agent is added to increase the stability of suspension, is prepared a kind of with bacteriostasis, the calamine lotion that property is stable, physiological property is strong.
Description
Technical field
The invention belongs to calamine lotion technical fields, and in particular, to a kind of calamine lotion with bacteriostasis.
Background technique
Calamine lotion is a kind of clinical application time longer common externally applied drug, has the work restrained and protect skin
With suitable for acute pruritic skin diseases such as nettle rash, prickly heats.
Calamine lotion preparation method is more, most commonly by calamine 50g, zinc oxide 150g and glycerol 50ml, adds
Appropriate amount of water, grinding, adding water makes into 1000ml, mix to get.But have by the calamine lotion that the tradition preparation method obtains
There is the defect that suspendability is poor, stability is bad.
Chinese patent CN102813674A then discloses the preparation method of another calamine lotion, the lotion every 100
Milliliter contains 150 grams of calamine, 50 grams of zinc oxide, 50 milliliters, 10 grams menthols of glycerol and 30 milliliters of injection liquid of gentamicin, surplus
For purified water.The patented technology declares, above drug prescription together can enhance antipruritic and antibacterial action, to causing pruritic skin
Each viroid of skin disease has collaboration inhibition and killing effect, to effectively mitigate pain, accelerate treatment process.Broad-spectrum antibiotic
The addition of gentamicin is able to suppress the bacteria breed of solution, however, the addition of gentamicin so that the calamine lotion not
It is suitable for all groups again, by the banned person that is used for gentamycin anaphylaxis, meanwhile, gentamicin has a degree of ear poison
Property, the clinical application of calamine lotion is limited instead.
And calamine lotion is in the specific application process, and there are suspendabilities not enough, itching-relieving action is weaker, and does not kill
The deficiencies of bacterium acts on.
Summary of the invention
The purpose of the present invention is to provide a kind of calamine lotions with bacteriostasis, to be modified calamine, zinc oxide
As the principle active component of lotion, the antibacterial of zinc oxide and calamine, convergence, anti-corrosion and itching-relieving efficacies are strong；By adding in right amount
Enter modified nano zinc oxide, modified nano zinc oxide can be uniformly distributed in lotion, assign lotion excellent bacteriostasis property；Together
When, the medicinal phenol of addition is able to extend the term of validity that said preparation uses, and increases preparation stability, enhances its sterilization, suppression
Bacterium, itching-relieving action；It by being added antibiotic into lotion, and being stabilized in lotion, can be improved the anti-inflammatory of lotion, receiving
The effects of holding back；Furthermore in the preparation process of calamine lotion, sodium carboxymethylcellulose suspending agent is added to increase suspension
Stability, sodium carboxymethylcellulose property are stablized, and are influenced small by pH value, hydration can be played around powder, is made in lotion
Particulate matter is uniformly dispersed in water, prevented from caking, and jog dissipates, to increase the dynamic stability of suspension, easily keeps
Suspension is prepared a kind of with bacteriostasis, the calamine lotion that property is stable, physiological property is strong.
The purpose of the present invention can be achieved through the following technical solutions:
A kind of calamine lotion with bacteriostasis, is made of the raw material of following parts by weight: calamine 140-160 parts modified,
45-55 parts of zinc oxide, phenol 8-10 parts medicinal, 6-8 parts of antibiotic, 10-12 parts of menthol, is spat 5-7 parts of modified nano zinc oxide
Warm 20 20-26 parts, 7-10 parts of glycerol, 2-3 parts of sodium carboxymethylcellulose, 800-900 parts of purified water；
The calamine lotion is made of following steps:
Step S1, sodium carboxymethylcellulose is added to the purified water of 10-15 times of its quality, carboxymethyl cellulose is made in stirring and dissolving
Plain sodium solution；
Step S2, medicinal phenol and antibiotic are mixed, is added according to solid-to-liquid ratio 1g:25-30mL into purified water, heated, make
Purified water is warming up to 68-72 DEG C, and stirring dissolves solid all, obtains the first mixed liquor；
Step S3, polysorbas20 is mixed with glycerol, is stirred evenly, obtain the second mixed liquor；
Step S4, zinc oxide is ground, after crossing 60 meshes, is mixed with modified calamine, modified nano zinc oxide, calamine is added
The 3-4 times of purified water measured, is ground into paste；
Step S5, continue to grind, first the second mixed liquor is slowly added to during the grinding process, obtains paste；
Step S6, carboxymethylcellulose sodium solution is slowly added in above-mentioned paste again, side edged keeps 60r/min at the uniform velocity suitable
Hour hands stirring, after adding, continues to grind, and the first mixed liquor is added, and side edged is ground；
Step S7, remaining purified water is added in said mixture, mixture is transferred to colloid mill, colloid mill suction line
Flow velocity is 3m/s, and colloid mill roll flute gap is 20 μm, revolving speed 3000r/min, and constant speed operating, glue grinds 50-60min, obtains institute
State calamine lotion.
Further, the modified calamine is prepared by the following method:
1) calamine is finely ground, 60 meshes are crossed, calamine powder is obtained；
2) calgon is added in deionized water, magnetic force whisks the hexa metaphosphoric acid for being made that concentration is 10g/L to being completely dissolved
Sodium solution；
3) calamine powder is added in sodium hexametaphosphate solution according to mass ratio 1:2, is sufficiently stirred under 2000r/min mixing speed
5-7min is mixed, slurry is made；
4) by made slurry, sealing and standing for 24 hours, stirs 10-12min again with 2000r/min mixing speed at room temperature, filters,
Product is dried, ground 60 mesh in 105 DEG C of baking ovens, modified calamine is made.
Further, the modified nano zinc oxide is prepared by the following method:
1) deionized water and dehydrated alcohol are mixed according to volume ratio 4:1, is configured to ethanol water；
2) it weighs 0.36g nano zine oxide to be added in 35mL ethanol water, is ultrasonically treated 60min；
3) it weighs 0.12g malonic acid to be dissolved into 28mL ethanol water, adds the NaOH solution of 2mol/L, adjust the pH of solution
Value is between 7-8；
4) solution for obtaining step 2 is added dropwise in the suspension of step 1), in 36 DEG C of temperature constant magnetic stirring oil bath pans with
500r/min stirs 180min；
5) by above-mentioned mixed liquor with ethanol washing 5-6 times, 15min is centrifuged with the speed of 6000r/min in centrifuge, then be placed in
Drying for 24 hours, obtains modified zinc oxide in 60 DEG C of vacuum ovens.
Further, the antibiotic is prepared by the following method:
1) Thiamphenicol is added to absolute ethanol, stirring and dissolving, is configured to the Thiamphenicol solution that concentration is 30g/L；By β-
Cyclodextrin is added in 65 DEG C of distilled water, stirring and dissolving, is configured to the beta-cyclodextrin solution that concentration is 45g/L；
2) beta-cyclodextrin solution is placed in 65 DEG C of water-bath, Thiamphenicol solution is added dropwise, the Thiamphenicol of addition is molten
The volume of liquid is the half of beta-cyclodextrin liquor capacity, after adding, lets cool, stands overnight in 0-3 DEG C of environment, through spraying naturally
Mist is dry, obtains antibiotic.
Beneficial effects of the present invention:
The main material for the calamine lotion that the present invention uses is modified calamine, and phosphonate dispersants are easy and Ca2+Form complexing
Object discharges calamine electric double layer thickness, enhances its water-swelling property, increases calamine particle layer thickness, and it is sweet to increase furnace
Stone particle while-face or while-side repulsion, prevent particle from contacting with each other, particle made to keep dispersed structure；Meanwhile metaphosphoric acid radical is logical
Perhydroxyl radical is in conjunction with calamine, and in calamine surface composition protective film, the space steric effect generated can effectively prevent soil
The formation of grain surface-to-surface association, plays the effect of enhancing calamine dispersion performance；Phosphate radical is adsorbed on calamine surface, displacement
The hydroxyl group on calamine surface forms one layer of isolation film (space for preventing from contacting with each other between particle in calamine particle surface
Steric effect), this isolation film can prevent particle from forming side-face association, promote the formation of surface-to-surface association, in addition, phosphate radical can
Increase calamine particle surface negative potential, increase intergranular repulsion, promote originally disorderly arranged particle in arranged in parallel, this
Two kinds of results reduce calamine-water pore volume, and then reduce its settling volume, improve the suspendability of calamine；
The present invention joined antibiotic in calamine lotion, the unstable chemcial property of Thiamphenicol solution, acid and
It is easily decomposed in alkaline solution, after beta-cyclodextrin inclusion compound, Thiamphenicol is included in hydrophobic cavity, and stability mentions significantly
It is high；It by being added antibiotic into lotion, and being stabilized in lotion, can be improved anti-inflammatory, the Thyme Extract of lotion；
The present invention joined modified nano zinc oxide in lotion, is modified by malonic acid to surface of nanometer zinc oxide, third
There are two carboxyl structures in diacid, can carry out esterification with the hydroxyl of surface of nanometer zinc oxide and generate ester bond, reduction is received
Rice grain is directly reunited, while not influencing its crystal structure and bacteriostasis property, so that nano zine oxide is dispersed in lotion
It is interior, assign lotion excellent bacteriostasis property；
For calamine lotion of the invention to be modified calamine, zinc oxide as the principle active component of lotion, zinc oxide and furnace are sweet
The antibacterial of stone, convergence, anti-corrosion and itching-relieving efficacies are strong；By the way that modified nano zinc oxide is added in right amount, modified nano zinc oxide can
It is uniformly distributed in lotion, assigns lotion excellent bacteriostasis property；Meanwhile the medicinal phenol of addition, being able to extend said preparation makes
Term of validity increases preparation stability, enhances its sterilization, antibacterial, itching-relieving action；By being added antibiotic to lotion
In, and be stabilized in lotion, it can be improved anti-inflammatory, the Thyme Extract of lotion；Furthermore in the preparation of calamine lotion
Cheng Zhong adds sodium carboxymethylcellulose suspending agent to increase the stability of suspension, and sodium carboxymethylcellulose property is stablized, by
PH value influence is small, and hydration can be played around powder, the particulate matter in lotion is made to be uniformly dispersed in water, prevented from caking,
Jog dissipates, to increase the dynamic stability of suspension, easily keeps suspension, is prepared a kind of with antibacterial work
With the calamine lotion that, property is stable, physiological property is strong.
Specific embodiment
Technical solution of the present invention is clearly and completely described below in conjunction with embodiment, it is clear that described reality
Applying example is only a part of the embodiment of the present invention, instead of all the embodiments.Based on the embodiments of the present invention, this field is general
Logical technical staff all other embodiment obtained without creative efforts belongs to what the present invention protected
Range.
A kind of calamine lotion with bacteriostasis, is made of the raw material of following parts by weight: modified calamine 140-160
Part, 45-55 parts of zinc oxide, 5-7 parts of modified nano zinc oxide, phenol 8-10 parts medicinal, 6-8 parts of antibiotic, menthol 10-12
Part, 20-26 parts of polysorbas20,7-10 parts of glycerol, 2-3 parts of sodium carboxymethylcellulose, 800-900 parts of purified water；
The modified calamine is prepared by the following method:
1) calamine is finely ground, 60 meshes are crossed, calamine powder is obtained；
2) calgon is added in deionized water, magnetic force whisks the hexa metaphosphoric acid for being made that concentration is 10g/L to being completely dissolved
Sodium solution；
3) calamine powder is added in sodium hexametaphosphate solution according to mass ratio 1:2, is sufficiently stirred under 2000r/min mixing speed
5-7min is mixed, slurry is made；
4) by made slurry, sealing and standing for 24 hours, stirs 10-12min again with 2000r/min mixing speed at room temperature, filters,
Product is dried, ground 60 mesh in 105 DEG C of baking ovens, modified calamine is made；
Phosphonate dispersants are easy and Ca2+Complex compound is formed, calamine electric double layer thickness is discharged, increases its water-swelling property
By force, increase calamine particle layer thickness, increase calamine particle while-face or while-side repulsion, prevent particle from contacting with each other,
Particle is set to keep dispersed structure；Meanwhile metaphosphoric acid radical by hydroxyl in conjunction with calamine, in calamine surface composition protective film,
Enhancing calamine dispersion performance is played in the formation that its space steric effect generated can effectively prevent soil particle surface-to-surface to associate
Effect；
Phosphate radical is adsorbed on calamine surface, replaces the hydroxyl group on calamine surface, forms one in calamine particle surface
Layer prevents the isolation film (space steric effect) to contact with each other between particle, and this isolation film can prevent particle from forming side-face association,
Promote the formation of surface-to-surface association to increase intergranular repulsion in addition, phosphate radical can increase calamine particle surface negative potential, promotees
Make originally that in arranged in parallel, both results reduce calamine-water pore volume, and then reduce for disorderly arranged particle
Its settling volume improves the suspendability of calamine；
The modified nano zinc oxide is prepared by the following method:
1) deionized water and dehydrated alcohol are mixed according to volume ratio 4:1, is configured to ethanol water；
2) it weighs 0.36g nano zine oxide to be added in 35mL ethanol water, is ultrasonically treated 60min；
3) it weighs 0.12g malonic acid to be dissolved into 28mL ethanol water, adds the NaOH solution of 2mol/L, adjust the pH of solution
Value is between 7-8；
4) solution for obtaining step 2 is added dropwise in the suspension of step 1), in 36 DEG C of temperature constant magnetic stirring oil bath pans with
500r/min stirs 180min；
5) by above-mentioned mixed liquor with ethanol washing 5-6 times, 15min is centrifuged with the speed of 6000r/min in centrifuge, then be placed in
Drying for 24 hours, obtains modified zinc oxide in 60 DEG C of vacuum ovens；
There are two carboxyl structures in malonic acid, can carry out esterification with the hydroxyl of surface of nanometer zinc oxide and generate ester bond,
It reduces nano particle directly to reunite, while not influencing its crystal structure and bacteriostasis property；
The antibiotic is prepared by the following method:
1) Thiamphenicol is added to absolute ethanol, stirring and dissolving, is configured to the Thiamphenicol solution that concentration is 30g/L；By β-
Cyclodextrin is added in 65 DEG C of distilled water, stirring and dissolving, is configured to the beta-cyclodextrin solution that concentration is 45g/L；
2) beta-cyclodextrin solution is placed in 65 DEG C of water-bath, Thiamphenicol solution is added dropwise, the Thiamphenicol of addition is molten
The volume of liquid is the half of beta-cyclodextrin liquor capacity, after adding, lets cool, stands overnight in 0-3 DEG C of environment, through spraying naturally
Mist is dry, obtains antibiotic；
The unstable chemcial property of Thiamphenicol solution easily decomposes in acid and alkaline solution, using beta-cyclodextrin packet
After conjunction, Thiamphenicol is included in hydrophobic cavity, and stability greatly improves；By being added antibiotic into lotion, and washing
It is stabilized in agent, can be improved anti-inflammatory, the Thyme Extract of lotion；
The calamine lotion is made of following steps:
Step S1, sodium carboxymethylcellulose is added to the purified water of 10-15 times of its quality, carboxymethyl cellulose is made in stirring and dissolving
Plain sodium solution；
Step S2, medicinal phenol and antibiotic are mixed, is added according to solid-to-liquid ratio 1g:25-30mL into purified water, heated, make
Purified water is warming up to 68-72 DEG C, and stirring dissolves solid all, obtains the first mixed liquor；
Step S3, polysorbas20 is mixed with glycerol, is stirred evenly, obtain the second mixed liquor；
Step S4, zinc oxide is ground, after crossing 60 meshes, is mixed with modified calamine, modified nano zinc oxide, calamine is added
The 3-4 times of purified water measured, is ground into paste；
Step S5, continue to grind, first the second mixed liquor is slowly added to during the grinding process, obtains paste；
Step S6, carboxymethylcellulose sodium solution is slowly added in above-mentioned paste again, side edged keeps 60r/min at the uniform velocity suitable
Hour hands stirring, after adding, continues to grind, and the first mixed liquor is added, and side edged is ground；
Step S7, remaining purified water is added in said mixture, mixture is transferred to colloid mill, colloid mill suction line
Flow velocity is 3m/s, and colloid mill roll flute gap is 20 μm, revolving speed 3000r/min, and constant speed operating, glue grinds 50-60min, obtains institute
State calamine lotion；
Abundant glue mill is finally carried out to lotion using colloid mill, material is by the high-frequency vibration of colloid mill, high speed vortex, friction
The physical actions such as power, shearing force, single-size granularity, reduce particle radius, reduce the rate of settling, reach emulsifying materials, dispersion,
Crush the effect with homogeneous；
The calamine lotion of preparation belongs to a kind of compound suspension, the antibacterial of zinc oxide and calamine therein, convergence, anti-corrosion and
Itching-relieving efficacies are strong, are chiefly used in the treatment of acute and subacute dermatitis, and menthol has a promoting blood ringing, detumescence, it is antipruritic and
Anti-inflammatory effect is good；Modified nano zinc oxide has good bacteriostasis property；Antibiotic can be improved the anti-inflammatory of lotion, convergence etc.
Effect.
Embodiment 1
A kind of calamine lotion with bacteriostasis, is made of the raw material of following parts by weight: modified 140 parts of calamine, oxidation
45 parts of zinc, 5 parts of modified nano zinc oxide, 8 parts of medicinal phenol, 6 parts of antibiotic, 10 parts of menthol, 20 parts of polysorbas20, glycerol 7
Part, 2 parts of sodium carboxymethylcellulose, 800 parts of purified water；
The calamine lotion is made of following steps:
Step S1, sodium carboxymethylcellulose is added to the purified water of 10 times of its quality, sodium carboxymethylcellulose is made in stirring and dissolving
Solution；
Step S2, medicinal phenol and antibiotic are mixed, is added according to solid-to-liquid ratio 1g:25mL into purified water, heated, make to purify
Water is warming up to 68 DEG C, and stirring dissolves solid all, obtains the first mixed liquor；
Step S3, polysorbas20 is mixed with glycerol, is stirred evenly, obtain the second mixed liquor；
Step S4, zinc oxide is ground, after crossing 60 meshes, is mixed with modified calamine, modified nano zinc oxide, calamine is added
The purified water of 3 times of amounts, is ground into paste；
Step S5, continue to grind, first the second mixed liquor is slowly added to during the grinding process, obtains paste；
Step S6, carboxymethylcellulose sodium solution is slowly added in above-mentioned paste again, side edged keeps 60r/min at the uniform velocity suitable
Hour hands stirring, after adding, continues to grind, and the first mixed liquor is added, and side edged is ground；
Step S7, remaining purified water is added in said mixture, mixture is transferred to colloid mill, colloid mill suction line
Flow velocity is 3m/s, and colloid mill roll flute gap is 20 μm, revolving speed 3000r/min, and constant speed operating, glue grinds 50min, obtains the furnace
Sweet granite-wash agent.
Embodiment 2
A kind of calamine lotion with bacteriostasis, is made of the raw material of following parts by weight: modified 150 parts of calamine, oxidation
50 parts of zinc, 6 parts of modified nano zinc oxide, 9 parts of medicinal phenol, 7 parts of antibiotic, 11 parts of menthol, 23 parts of polysorbas20, glycerol 8.5
Part, 2.5 parts of sodium carboxymethylcellulose, 850 parts of purified water；
The calamine lotion is made of following steps:
Step S1, sodium carboxymethylcellulose is added to the purified water of 13 times of its quality, sodium carboxymethylcellulose is made in stirring and dissolving
Solution；
Step S2, medicinal phenol and antibiotic are mixed, is added according to solid-to-liquid ratio 1g:28mL into purified water, heated, make to purify
Water is warming up to 70 DEG C, and stirring dissolves solid all, obtains the first mixed liquor；
Step S3, polysorbas20 is mixed with glycerol, is stirred evenly, obtain the second mixed liquor；
Step S4, zinc oxide is ground, after crossing 60 meshes, is mixed with modified calamine, modified nano zinc oxide, calamine is added
The purified water of 3.5 times of amounts, is ground into paste；
Step S5, continue to grind, first the second mixed liquor is slowly added to during the grinding process, obtains paste；
Step S6, carboxymethylcellulose sodium solution is slowly added in above-mentioned paste again, side edged keeps 60r/min at the uniform velocity suitable
Hour hands stirring, after adding, continues to grind, and the first mixed liquor is added, and side edged is ground；
Step S7, remaining purified water is added in said mixture, mixture is transferred to colloid mill, colloid mill suction line
Flow velocity is 3m/s, and colloid mill roll flute gap is 20 μm, revolving speed 3000r/min, and constant speed operating, glue grinds 55min, obtains the furnace
Sweet granite-wash agent.
Embodiment 3
A kind of calamine lotion with bacteriostasis, is made of the raw material of following parts by weight: modified 160 parts of calamine, oxidation
55 parts of zinc, 7 parts of modified nano zinc oxide, 10 parts of medicinal phenol, 8 parts of antibiotic, 12 parts of menthol, 26 parts of polysorbas20, glycerol 10
Part, 3 parts of sodium carboxymethylcellulose, 900 parts of purified water；
The calamine lotion is made of following steps:
Step S1, sodium carboxymethylcellulose is added to the purified water of 15 times of its quality, sodium carboxymethylcellulose is made in stirring and dissolving
Solution；
Step S2, medicinal phenol and antibiotic are mixed, is added according to solid-to-liquid ratio 1g:30mL into purified water, heated, make to purify
Water is warming up to 72 DEG C, and stirring dissolves solid all, obtains the first mixed liquor；
Step S3, polysorbas20 is mixed with glycerol, is stirred evenly, obtain the second mixed liquor；
Step S4, zinc oxide is ground, after crossing 60 meshes, is mixed with modified calamine, modified nano zinc oxide, calamine is added
The purified water of 4 times of amounts, is ground into paste；
Step S5, continue to grind, first the second mixed liquor is slowly added to during the grinding process, obtains paste；
Step S6, carboxymethylcellulose sodium solution is slowly added in above-mentioned paste again, side edged keeps 60r/min at the uniform velocity suitable
Hour hands stirring, after adding, continues to grind, and the first mixed liquor is added, and side edged is ground；
Step S7, remaining purified water is added in said mixture, mixture is transferred to colloid mill, colloid mill suction line
Flow velocity is 3m/s, and colloid mill roll flute gap is 20 μm, revolving speed 3000r/min, and constant speed operating, glue grinds 60min, obtains the furnace
Sweet granite-wash agent.
Following performance test is done to the embodiment 1-3 calamine lotion being prepared:
Bacteriostasis property is evaluated with minimal inhibitory concentration (MIC), minimum suppression is done to the embodiment 1-3 calamine lotion being prepared
Bacteria concentration test, tests bacteriostasis rate, test result is as follows table:
It is found that the lotion that the present invention is prepared is 48.9% or more to the Mlc of Escherichia coli, to staphylococcus aureus
Mlc be 47.5% or more, compared to common commercially available calamine lotion, the lotion that the present invention obtains has good antibacterial
Performance.
Present invention disclosed above preferred embodiment is only intended to help to illustrate the present invention.There is no detailed for preferred embodiment
All details are described, are not limited the invention to the specific embodiments described.Obviously, according to the content of this specification,
It can make many modifications and variations.These embodiments are chosen and specifically described to this specification, is in order to better explain the present invention
Principle and practical application, so that skilled artisan be enable to better understand and utilize the present invention.The present invention is only
It is limited by claims and its full scope and equivalent.
Claims (4)
1. a kind of calamine lotion with bacteriostasis, which is characterized in that be made of the raw material of following parts by weight: modified furnace is sweet
140-160 parts of stone, 45-55 parts of zinc oxide, 5-7 parts of modified nano zinc oxide, phenol 8-10 parts medicinal, 6-8 parts of antibiotic, peppermint
10-12 parts of brain, 20-26 parts of polysorbas20,7-10 parts of glycerol, 2-3 parts of sodium carboxymethylcellulose, 800-900 parts of purified water；
The calamine lotion is made of following steps:
Step S1, sodium carboxymethylcellulose is added to the purified water of 10-15 times of its quality, carboxymethyl cellulose is made in stirring and dissolving
Plain sodium solution；
Step S2, medicinal phenol and antibiotic are mixed, is added according to solid-to-liquid ratio 1g:25-30mL into purified water, heated, make
Purified water is warming up to 68-72 DEG C, and stirring dissolves solid all, obtains the first mixed liquor；
Step S3, polysorbas20 is mixed with glycerol, is stirred evenly, obtain the second mixed liquor；
Step S4, zinc oxide is ground, after crossing 60 meshes, is mixed with modified calamine, modified nano zinc oxide, calamine is added
The 3-4 times of purified water measured, is ground into paste；
Step S5, continue to grind, first the second mixed liquor is slowly added to during the grinding process, obtains paste；
Step S6, carboxymethylcellulose sodium solution is slowly added in above-mentioned paste again, side edged keeps 60r/min at the uniform velocity suitable
Hour hands stirring, after adding, continues to grind, and the first mixed liquor is added, and side edged is ground；
Step S7, remaining purified water is added in said mixture, mixture is transferred to colloid mill, colloid mill suction line
Flow velocity is 3m/s, and colloid mill roll flute gap is 20 μm, revolving speed 3000r/min, and constant speed operating, glue grinds 50-60min, obtains institute
State calamine lotion.
2. a kind of calamine lotion with bacteriostasis according to claim 1, which is characterized in that the modified furnace is sweet
Stone is prepared by the following method:
1) calamine is finely ground, 60 meshes are crossed, calamine powder is obtained；
2) calgon is added in deionized water, magnetic force whisks the hexa metaphosphoric acid for being made that concentration is 10g/L to being completely dissolved
Sodium solution；
3) calamine powder is added in sodium hexametaphosphate solution according to mass ratio 1:2, is sufficiently stirred under 2000r/min mixing speed
5-7min is mixed, slurry is made；
4) by made slurry, sealing and standing for 24 hours, stirs 10-12min again with 2000r/min mixing speed at room temperature, filters,
Product is dried, ground 60 mesh in 105 DEG C of baking ovens, modified calamine is made.
3. a kind of calamine lotion with bacteriostasis according to claim 1, which is characterized in that the modified Nano
Zinc oxide is prepared by the following method:
1) deionized water and dehydrated alcohol are mixed according to volume ratio 4:1, is configured to ethanol water；
2) it weighs 0.36g nano zine oxide to be added in 35mL ethanol water, is ultrasonically treated 60min；
3) it weighs 0.12g malonic acid to be dissolved into 28mL ethanol water, adds the NaOH solution of 2mol/L, adjust the pH of solution
Value is between 7-8；
4) solution for obtaining step 2 is added dropwise in the suspension of step 1), in 36 DEG C of temperature constant magnetic stirring oil bath pans with
500r/min stirs 180min；
5) by above-mentioned mixed liquor with ethanol washing 5-6 times, 15min is centrifuged with the speed of 6000r/min in centrifuge, then be placed in
Drying for 24 hours, obtains modified zinc oxide in 60 DEG C of vacuum ovens.
4. a kind of calamine lotion with bacteriostasis according to claim 1, which is characterized in that the antibiotic by
Following method preparation:
1) Thiamphenicol is added to absolute ethanol, stirring and dissolving, is configured to the Thiamphenicol solution that concentration is 30g/L；By β-
Cyclodextrin is added in 65 DEG C of distilled water, stirring and dissolving, is configured to the beta-cyclodextrin solution that concentration is 45g/L；
2) beta-cyclodextrin solution is placed in 65 DEG C of water-bath, Thiamphenicol solution is added dropwise, the Thiamphenicol of addition is molten
The volume of liquid is the half of beta-cyclodextrin liquor capacity, after adding, lets cool, stands overnight in 0-3 DEG C of environment, through spraying naturally
Mist is dry, obtains antibiotic.
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Cited By (2)
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| CN112516002A (en) * | 2020-12-15 | 2021-03-19 | 彭氏(惠州)实业发展有限公司 | Shower gel containing calamine and preparation method thereof |
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Application publication date: 20190426 |