CN115715993B - Micro-droplet control method based on photo-thermal effect - Google Patents
Micro-droplet control method based on photo-thermal effect Download PDFInfo
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- CN115715993B CN115715993B CN202211213370.4A CN202211213370A CN115715993B CN 115715993 B CN115715993 B CN 115715993B CN 202211213370 A CN202211213370 A CN 202211213370A CN 115715993 B CN115715993 B CN 115715993B
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Abstract
The invention discloses a micro-droplet control method based on a photo-thermal effect, which comprises the following steps of: s1, dripping liquid to be detected on a glass slide and placing the glass slide on a micro-operation platform; s2, horizontally placing the optical fiber probe connected with the laser in the liquid to be tested by utilizing a micro-operation platform; s3, forming an optical fiber light field in the liquid to be detected by the optical fiber probe, and forming a heating area; s4, absorbing energy in a heating area to generate a large amount of steam, enabling the hot steam flow to rise and condense into micro-droplets when meeting cold air, and enabling the micro-droplets to be suspended and captured under the effect of Bernoulli effect; and S5, moving the optical fiber probe, changing a heating area, and realizing movement of micro liquid drops under the effect of Bernoulli effect. The micro-droplet control method of the photo-thermal effect, disclosed by the invention, can realize suspension capture and control of micro-droplets under the irradiation of an optical fiber light field by applying the photo-thermal effect and the Bernoulli effect, has the advantages of fixed point and controllability, and has the characteristics of simplicity, flexibility and convenience in operation.
Description
Technical Field
The invention relates to the technical field of droplet control, in particular to a micro-droplet control method based on a photo-thermal effect.
Background
Flexible manipulation of droplets is of great importance for biomedical research and production in the chemical industry. In recent years, not only has there been a lot of development in microfluidic channels, but also there has been a significant advancement in manipulating droplets in free space. Among these are various methods using electrical, magnetic, acoustic and optical to actively manipulate the movement pattern of the droplets. As optics evolves, the combination of light and microfluidics creates optofluidics. The method for controlling the micro-droplets is expanded by combining the optical methods such as micro-droplets and optical fibers.
In recent years, a method for controlling liquid drops by using a photo-thermal effect has achieved a certain result. Chinese patent CN201811167396.3 discloses a photo-thermal directional control droplet transfer polymerization apparatus and a method for using the same, and proposes a device for heating a liquid by light to generate vapor to push a droplet to move, and the movement of the droplet can be achieved by generating asymmetric vapor through eccentric heating. But the droplets move in the channel and the individual degree of manipulation of the droplets is therefore limited. Chinese patent CN202110670202.7 discloses a three-dimensional migration device for photo-thermal control of liquid droplets and a method for using the same, and proposes a device for locally heating liquid by light to change the stress of the liquid droplets so as to realize movement of the liquid droplets, and changing the movement condition of the liquid droplets by changing different positions of the irradiated liquid droplets. However, the droplets controlled by the method are contacted with the solution, the environmental requirements for controlling the droplets are high, the density requirements for the solution are high, and the droplets need to be coated with a film in a container. Since the droplets are laser irradiated in the solution, the solution affects the laser irradiation of the droplets.
Sara Nagelberg et al (Physical review letters,2021,127 (14): 144503.) propose a mechanism for droplet actuation using thermal capillary action by irradiating droplets to change the temperature gradient to create fluid movement and move the droplets. But accurate control of the droplets requires relatively complex experimental equipment. YIlin Chen et al (Optics Letters,2020,45 (7): 1998-2001.) studied a microfluidic chip that controlled droplet size and shape with light, and could control droplets by adjusting the light power. The droplets in the microfluidic chip will be confined to the chip and the range of droplet manipulation will be limited.
Disclosure of Invention
The invention aims to provide a micro-droplet control method based on photo-thermal effect, which solves the technical problems. The invention can realize flexible control of micro-droplets based on photo-thermal effect.
In order to achieve the above object, the present invention provides a micro-droplet manipulation method based on photo-thermal effect, comprising the following steps:
s1, dripping liquid to be detected on a glass slide, and placing the glass slide on a micro-operation platform;
s2, horizontally placing the optical fiber probe connected with the laser in the liquid to be tested by utilizing a micro-operation platform, and controlling the position of the optical fiber probe in the liquid to be tested by utilizing the micro-operation platform;
s3, turning on the laser, forming an optical fiber light field in the liquid to be detected by the optical fiber probe, absorbing the energy of the light field by the liquid to be detected, accumulating heat, and forming a heating area in the liquid to be detected;
s4, absorbing energy by a heating area to generate a large amount of steam, enabling the hot steam flow to rise and condense into micro-droplets when meeting cold air, and enabling the micro-droplets to be suspended and captured under the effect of Bernoulli effect when the gravity of the micro-droplets is balanced with the lifting force of the rising hot steam flow; imaging the micro-droplets by using a CCD camera and displaying the result on a computer;
s5, moving the optical fiber probe through the micro-operation platform, changing the heating area, and realizing the movement of micro-droplets under the effect of Bernoulli effect, wherein the flow speed of the hot steam flow at one side of the new heating area is high, the pressure is low.
Preferably, the wavelength of the output light of the laser is the corresponding wavelength with a larger absorption coefficient of the liquid to be measured.
Preferably, the number, the size and the distance from the micro liquid drops to the liquid to be measured are adjusted by the output power of the laser.
The micro-droplet control method based on the photo-thermal effect has the advantages and positive effects that:
1. the invention relates to a method for controlling micro-droplets by a photo-thermal effect, which can realize suspension and movement of the micro-droplets on the surface of liquid to be detected.
2. The invention has higher flexibility. The optical fiber is small, flexible and convenient to operate, the transmitted light can control the position and irradiate a certain area, so that the micro-droplet control is realized by the optical fiber more flexibly and conveniently relative to other modes.
3. The invention has strong applicability. For micro-droplets of different experiments, the wavelength of the laser is changed to realize the control of the micro-droplets.
4. The invention has higher feasibility. Compared with the traditional method for controlling the liquid drops by using the microfluidic chip, the method can control the liquid drops more simply, flexibly and adjustably without connecting an external injection pump and a valve.
5. The invention has little pollution to the sample. Micro-droplet manipulation is a manipulation suspended on the surface of a liquid, and non-contact.
6. The method is simple and has low cost. The optical fiber probe used in the invention is simply processed or not processed by optical fibers.
The technical scheme of the invention is further described in detail through the drawings and the embodiments.
Drawings
FIG. 1 is a schematic diagram of a micro-droplet manipulation method according to an embodiment of the present invention;
fig. 2 is a schematic structural diagram of a micro-droplet control device according to an embodiment of a photo-thermal effect-based micro-droplet control method of the present invention.
Reference numerals
1. A liquid to be measured; 2. a glass slide; 3. an optical fiber probe; 4. a heating zone; 5. a flow of hot steam; 6. cold air; 7. a microdroplet; 8. a laser; 9. a micro-operation platform; 10. a CCD camera; 11. and a computer.
Detailed Description
The technical scheme of the invention is further described below through the attached drawings and the embodiments.
Examples
Fig. 1 is a schematic diagram of a model structure of an embodiment of a micro-droplet control method based on a photo-thermal effect according to the present invention, and fig. 2 is a schematic diagram of an embodiment of a micro-droplet control device based on a photo-thermal effect according to the present invention. As shown in the figure, the micro-droplet control method based on photo-thermal effect comprises the following steps:
s1, dripping distilled water of liquid 1 to be tested on a glass slide 2, and placing the glass slide 2 on a micro-operation platform 9; the micro-operation platform 9 can select the current model or structure according to the requirement.
S2, horizontally placing the optical fiber probe 3 connected with the laser 8 in distilled water of the liquid 1 to be tested by utilizing the micro-operation platform 9, and controlling the position of the optical fiber probe 3 in the liquid 1 to be tested by utilizing the micro-operation platform 9.
S3, turning on a laser 8, forming an optical fiber light field in distilled water of the liquid 1 to be detected by the optical fiber probe 3, transmitting 1480nm wavelength laser to the distilled water of the liquid 1 to be detected by the optical fiber probe 3, wherein the optical fiber probe 3 is made of single-mode optical fiber, and the end face is a plane. The distilled water of the liquid 1 to be measured absorbs the energy of the light field and accumulates heat, and the heat in the light field area cannot be transferred or the transfer speed is low, so that the distilled water is heated in the area by the light, and a heating area 4 is formed in the liquid 1 to be measured.
S4, absorbing energy by the heating area 4, generating a large amount of steam, enabling the hot steam flow 5 to rise above distilled water of the liquid 1 to be detected and enabling the cold air 6 to be condensed into a plurality of micro-droplets 7 with different sizes, and enabling the micro-droplets 7 to be suspended and captured under the effect of Bernoulli effect when the gravity of the micro-droplets 7 is balanced with the lifting force of the rising hot steam flow 5; the micro-droplets 7 are imaged with a CCD camera 10 and the result is displayed on a computer 11.
S5, moving the optical fiber probe 3 through the micro-operation platform 9, changing the heating area 4, and realizing the movement of the micro-droplet 7 under the effect of Bernoulli effect, wherein the flow speed of the hot steam flow 5 at one side of the new heating area 4 is high, the pressure is low.
The micro-operation platform 9 is controlled to move the optical fiber probe 3 rightwards, the heating area 4 correspondingly moves rightwards, distilled water of the liquid 1 to be detected in the new heating area 4 absorbs light energy and carries out heat accumulation, and steam and hot steam flow 5 are formed on the surface; the flow of hot vapor 5 to the right of the microdroplet 7 is slower than the flow of cold air 6 in the other direction, resulting in a small pressure, and the microdroplet 7 moves to the right under the effect of the bernoulli effect.
The number, size, and distance of the micro-droplets 7 to the liquid 1 to be measured are adjusted by the output power of the laser 8. Increasing the power of the laser 8 can observe that the number of micro-droplets 7 on the distilled water surface increases, the volume of the micro-droplets 7 increases, and the distance from the micro-droplets 7 to the liquid surface increases.
Therefore, the micro-droplet control method of the photo-thermal effect, disclosed by the invention, can realize suspension capture and control of micro-droplets by applying the photo-thermal effect and the Bernoulli effect under the irradiation of an optical fiber light field, and can move the micro-droplets by moving the optical fiber probe; the method has the advantages of fixed point and controllability, and has the characteristics of simplicity, flexibility and convenience in operation; the technology development of researching micro-droplets at fixed points can be promoted, and the application range of the micro-droplet control technology is expanded.
Finally, it should be noted that: the above embodiments are only for illustrating the technical solution of the present invention and not for limiting it, and although the present invention has been described in detail with reference to the preferred embodiments, it will be understood by those skilled in the art that: the technical scheme of the invention can be modified or replaced by the same, and the modified technical scheme cannot deviate from the spirit and scope of the technical scheme of the invention.
Claims (3)
1. The micro-droplet control method based on the photo-thermal effect is characterized by comprising the following steps of:
s1, dripping liquid to be detected on a glass slide, and placing the glass slide on a micro-operation platform;
s2, horizontally placing the optical fiber probe connected with the laser in the liquid to be tested by utilizing a micro-operation platform, and controlling the position of the optical fiber probe in the liquid to be tested by utilizing the micro-operation platform;
s3, turning on the laser, forming an optical fiber light field in the liquid to be detected by the optical fiber probe, absorbing the energy of the light field by the liquid to be detected, accumulating heat, and forming a heating area in the liquid to be detected;
s4, absorbing energy by a heating area to generate a large amount of steam, enabling the hot steam flow to rise and condense into micro-droplets when meeting cold air, and enabling the micro-droplets to be suspended and captured under the effect of Bernoulli effect when the gravity of the micro-droplets is balanced with the lifting force of the rising hot steam flow; imaging the micro-droplets by using a CCD camera and displaying the result on a computer;
s5, moving the optical fiber probe through the micro-operation platform, changing the heating area, and realizing the movement of micro-droplets under the effect of Bernoulli effect, wherein the flow speed of the hot steam flow at one side of the new heating area is high, the pressure is low.
2. The method for controlling micro-droplets based on photo-thermal effect according to claim 1, wherein the method comprises the following steps: the wavelength of the output light of the laser is the corresponding wavelength with larger absorption coefficient of the liquid to be detected.
3. The method for controlling micro-droplets based on photo-thermal effect according to claim 1, wherein the method comprises the following steps: the number, the size and the distance between the micro liquid drops and the liquid to be measured are adjusted through the output power of the laser.
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Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108246372A (en) * | 2018-01-23 | 2018-07-06 | 河北工业大学 | A kind of reciprocal feeding device of real-time controllable microlayer model and method based on lithium niobate sandwich chip |
| CN109289948A (en) * | 2018-10-08 | 2019-02-01 | 重庆大学 | A kind of photo-thermal orientation manipulation drop migration polyplant and its application method |
| CN112216418A (en) * | 2020-08-31 | 2021-01-12 | 桂林电子科技大学 | Integrated single fiber droplet manipulator |
| CN113340693A (en) * | 2021-06-17 | 2021-09-03 | 重庆大学 | Photo-thermal control liquid drop three-dimensional migration device and using method |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| US7582858B2 (en) * | 2004-01-23 | 2009-09-01 | Sri International | Apparatus and method of moving micro-droplets using laser-induced thermal gradients |
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Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108246372A (en) * | 2018-01-23 | 2018-07-06 | 河北工业大学 | A kind of reciprocal feeding device of real-time controllable microlayer model and method based on lithium niobate sandwich chip |
| CN109289948A (en) * | 2018-10-08 | 2019-02-01 | 重庆大学 | A kind of photo-thermal orientation manipulation drop migration polyplant and its application method |
| CN112216418A (en) * | 2020-08-31 | 2021-01-12 | 桂林电子科技大学 | Integrated single fiber droplet manipulator |
| CN113340693A (en) * | 2021-06-17 | 2021-09-03 | 重庆大学 | Photo-thermal control liquid drop three-dimensional migration device and using method |
Non-Patent Citations (1)
| Title |
|---|
| 光热效应致液滴相 变过程中的热质传递特性及界面行为;焦龙;CNKI 博士学位论文全文库 工程科技II 辑(第2021 年第 01 期);第22-24, 52-56, 65-66页 * |
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