CN115715993A - Micro-droplet control method based on photoinduced thermal effect - Google Patents
Micro-droplet control method based on photoinduced thermal effect Download PDFInfo
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- CN115715993A CN115715993A CN202211213370.4A CN202211213370A CN115715993A CN 115715993 A CN115715993 A CN 115715993A CN 202211213370 A CN202211213370 A CN 202211213370A CN 115715993 A CN115715993 A CN 115715993A
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Abstract
The invention discloses a micro-droplet control method based on a photoinduced thermal effect, which comprises the following steps of: s1, dripping liquid to be detected on a glass slide and placing the glass slide on a micro-operation platform; s2, horizontally placing the optical fiber probe connected with the laser in the liquid to be detected by using a micro-operation platform; s3, forming an optical fiber light field in the liquid to be detected by the optical fiber probe, and forming a heating area; s4, absorbing energy by the heating area to generate a large amount of steam, condensing the hot steam flow into micro-droplets when the hot steam flow rises and meets the cold air, and capturing the micro-droplets in a suspended manner under the action of the Bernoulli effect; s5, moving the optical fiber probe, changing a heating region, and realizing the movement of the micro-droplets under the action of the Bernoulli effect. According to the micro-droplet control method based on the photo-induced thermal effect, the photo-induced thermal effect and the Bernoulli effect are applied, suspension capture and control of micro-droplets can be achieved under the irradiation of an optical fiber light field, and the micro-droplet control method based on the photo-induced thermal effect has the advantages of being fixed in point, controllable, simple, flexible and convenient to operate.
Description
Technical Field
The invention relates to the technical field of droplet control, in particular to a micro-droplet control method based on a photoinduced thermal effect.
Background
The flexible manipulation of droplets is of great importance for biomedical research and for the production of the chemical industry. In recent years, manipulation of droplets has not only advanced in microfluidic channels, but also in free space. Various methods of electricity, magnetism, sound, and light are used to actively manipulate the motion pattern of the liquid droplets. As optics evolved, the combination of light and microfluidics produced optofluidics. Combines optical methods such as micro-droplets and optical fibers, and expands the method for controlling the micro-droplets.
In recent years, certain efforts have been made to manipulate droplets using photothermal effects. Chinese patent CN201811167396.3 discloses a photo-thermal directional control liquid drop transfer polymerization device and a method for using the same, and proposes a device for pushing liquid drops to move by heating liquid to generate vapor through light, and the movement of liquid drops can be realized by generating asymmetric vapor through eccentric heating. But the droplets move in the channel and the individual degree of manipulation of the droplets is therefore limited. Chinese patent CN202110670202.7 discloses a photo-thermal control liquid drop three-dimensional transfer device and a use method thereof, and proposes a device for locally heating liquid by light to change the force applied to the liquid drop to realize the movement of the liquid drop, and changes the motion condition of the liquid drop by changing different positions of the irradiated liquid drop. But the droplets and the solution are in contact, and the environment for manipulating the droplets is high, the density requirement for the solution is high, and the droplets need to be coated with a film in a container. Since the droplet is irradiated with the laser in the solution, the solution affects the laser irradiation of the droplet.
Sara Nagelberg et al (Physical review letters,2021,127 (14): 144503) propose a mechanism for droplet actuation using thermal capillary action to alter the temperature gradient by irradiating the droplets with light to create fluid motion and to move the droplets. However, accurate control of the droplets requires relatively complex experimental equipment. Yilin Chen et al (Optics Letters,2020,45 (7): 1998-2001) have studied a microfluidic chip that controls droplet size and shape with light, and can adjust the light power to control the droplet. The liquid drops in the microfluidic chip can be limited in the chip, and the control range of the liquid drops can be limited.
Disclosure of Invention
The invention aims to provide a micro-droplet control method based on a photo-induced thermal effect, and the micro-droplet control method solves the technical problems. The invention can realize flexible control of micro-droplets based on the photo-induced thermal effect.
In order to achieve the purpose, the invention provides a micro-droplet control method based on a photoinduced thermal effect, which comprises the following steps of:
s1, dripping liquid to be detected on a glass slide, and placing the glass slide on a micro-operation platform;
s2, horizontally placing the optical fiber probe connected with the laser in the liquid to be detected by using a micro-operation platform, and controlling the position of the optical fiber probe in the liquid to be detected by using the micro-operation platform;
s3, turning on a laser, enabling an optical fiber probe to form an optical fiber light field in the liquid to be detected, enabling the liquid to be detected to absorb energy of the light field and accumulate heat, and forming a heating area in the liquid to be detected;
s4, absorbing energy by the heating area to generate a large amount of steam, condensing the hot steam flow into micro-droplets when the hot steam flow rises and meets the cold air, and when the gravity of the micro-droplets and the lifting force of the rising hot steam flow are balanced, the micro-droplets are suspended and captured under the action of the Bernoulli effect; imaging the micro-droplets by using a CCD camera and displaying the result on a computer;
s5, the optical fiber probe is moved through the micro operation platform, the heating area is changed, the flow rate of hot steam flow at one side of the new heating area is high, the pressure is low, and micro liquid drops are moved under the action of the Bernoulli effect.
Preferably, the wavelength of the output light of the laser is a corresponding wavelength with a larger absorption coefficient of the liquid to be measured.
Preferably, the number and size of the micro-droplets and the distance from the droplets to the liquid to be measured are adjusted by the output power of the laser.
The micro-droplet control method based on the photo-induced thermal effect has the advantages and positive effects that:
1. the invention relates to a method for controlling micro-droplets through a photo-induced thermal effect, which can realize the suspension and respective degree of freedom movement of the micro-droplets on the surface of a liquid to be detected.
2. The invention has higher flexibility. The optical fiber is small, exquisite, flexible and convenient to operate, the position can be controlled by transmitted light, and a certain area is irradiated, so that the micro-droplet control is more flexible and convenient compared with other modes by using the optical fiber.
3. The invention has strong applicability. For the micro-droplets of different experiments, the wavelength of the laser is changed to realize the control of the micro-droplets.
4. The invention has high feasibility. Compared with the traditional method for controlling the liquid drops by the microfluidic chip, the method can control the liquid drops more simply, flexibly and adjustably without externally connecting an injection pump and a valve.
5. The invention has little pollution to the sample. The micro-droplet manipulation is suspended on the surface of the liquid, and is non-contact manipulation.
6. The method is simple and low in cost. The optical fiber probe used in the invention is obtained by simply processing or not processing the optical fiber.
The technical solution of the present invention is further described in detail by the accompanying drawings and embodiments.
Drawings
FIG. 1 is a schematic diagram of a model structure of an embodiment of a method for controlling micro-droplets based on a photo-induced thermal effect according to the present invention;
fig. 2 is a schematic structural diagram of a device for controlling micro-droplets according to an embodiment of a micro-droplet control method based on a photo-induced thermal effect.
Reference numerals
1. Liquid to be measured; 2. glass slide; 3. a fiber optic probe; 4. a heating zone; 5. a flow of hot steam; 6. cooling the air; 7. micro-droplets; 8. a laser; 9. a micro-operation platform; 10. a CCD camera; 11. a computer.
Detailed Description
The technical solution of the present invention is further illustrated by the accompanying drawings and examples.
Examples
Fig. 1 is a schematic model structure diagram of an embodiment of a method for controlling microdroplets based on a photo-induced thermal effect, and fig. 2 is a schematic structure diagram of an apparatus for controlling microdroplets in an embodiment of a method for controlling microdroplets based on a photo-induced thermal effect. As shown in the figure, a micro-droplet control method based on a photo-induced thermal effect, in which a liquid 1 to be measured is distilled water, includes the following steps:
s1, dripping distilled water of liquid 1 to be detected on a glass slide 2, and placing the glass slide 2 on a micro-operation platform 9; the micro operation platform 9 can select the current model or structure according to the requirement.
S2, horizontally placing the optical fiber probe 3 connected with the laser 8 in the distilled water of the liquid 1 to be detected by using the micro-operation platform 9, and controlling the position of the optical fiber probe 3 in the liquid 1 to be detected by using the micro-operation platform 9.
S3, the laser 8 is turned on, the optical fiber probe 3 forms an optical fiber light field in the liquid 1 to be detected distilled water, the optical fiber probe 3 transmits laser with a 1480nm wavelength into the liquid 1 to be detected distilled water, the optical fiber probe 3 is made of single mode fiber, and the end face is a plane. The distilled water of the liquid 1 to be detected absorbs the energy of the light field and accumulates the heat, and the heat in the light field area cannot be transferred or the transfer speed is low, so that the distilled water is subjected to area heating by the light, and a heating area 4 is formed in the liquid 1 to be detected.
S4, absorbing energy by the heating area 4 to generate a large amount of steam, enabling the hot steam flow 5 to rise above the distilled water of the liquid 1 to be detected and be condensed into a plurality of micro-droplets 7 with different sizes by meeting with the cold air 6, and when the gravity of the micro-droplets 7 and the lifting force of the rising hot steam flow 5 are balanced, enabling the micro-droplets 7 to be suspended and captured under the action of the Bernoulli effect; the microdroplets 7 are imaged with a CCD camera 10 and the results are displayed on a computer 11.
S5, the optical fiber probe 3 is moved through the micro-operation platform 9, the heating area 4 is changed, the flow rate of the hot steam flow 5 on one side of the new heating area 4 is high, the pressure is low, and the micro-liquid drop 7 is moved under the action of the Bernoulli effect.
The micro-operation platform 9 is controlled to move the optical fiber probe 3 rightwards, the heating area 4 correspondingly moves rightwards, the distilled water of the liquid 1 to be measured in the new heating area 4 absorbs light energy and accumulates heat, and water vapor and hot vapor flow 5 are formed on the surface; the flow velocity of the hot vapor stream 5 to the right of the micro-droplets 7 is slower than the flow velocity of the cold air 6 in the other direction, resulting in a lower pressure, and the micro-droplets 7 move to the right under the bernoulli effect.
The number and size of the micro-droplets 7 and the distance between the droplets and the liquid 1 to be measured are adjusted by the output power of the laser 8. Increasing the power of the laser 8 can observe that the number of the micro-droplets 7 on the surface of the distilled water is increased, the volume of the micro-droplets 7 is increased, and the distance from the micro-droplets 7 to the liquid surface is increased.
Therefore, the micro-droplet control method based on the photoinduced thermal effect provided by the invention can realize the suspension capture and control of micro-droplets by applying the photoinduced thermal effect and the Bernoulli effect under the irradiation of the optical fiber optical field, and the micro-droplets are moved by moving the optical fiber probe; the device not only has the advantages of fixed point and controllability, but also has the characteristics of simplicity, flexibility and convenience in operation; the method can promote the technical development of fixed-point research of the micro-droplets and expand the application range of the micro-droplet control technology.
Finally, it should be noted that: the above embodiments are only for illustrating the technical solutions of the present invention and not for limiting the same, and although the present invention is described in detail with reference to the preferred embodiments, those of ordinary skill in the art should understand that: modifications and equivalents may be made to the invention without departing from the spirit and scope of the invention.
Claims (3)
1. A micro-droplet control method based on a photoinduced thermal effect is characterized by comprising the following steps:
s1, dripping liquid to be detected on a glass slide, and placing the glass slide on a micro-operation platform;
s2, horizontally placing the optical fiber probe connected with the laser in the liquid to be detected by using a micro-operation platform, and controlling the position of the optical fiber probe in the liquid to be detected by using the micro-operation platform;
s3, turning on a laser, enabling an optical fiber probe to form an optical fiber light field in the liquid to be detected, enabling the liquid to be detected to absorb energy of the light field and accumulate heat, and forming a heating area in the liquid to be detected;
s4, absorbing energy by the heating area to generate a large amount of steam, condensing the hot steam flow into micro-droplets when the hot steam flow rises and meets the cold air, and when the gravity of the micro-droplets and the lifting force of the rising hot steam flow are balanced, the micro-droplets are suspended and captured under the action of the Bernoulli effect; imaging the micro-droplets by using a CCD camera and displaying the result on a computer;
s5, the optical fiber probe is moved through the micro operation platform, the heating area is changed, the flow rate of hot steam flow at one side of the new heating area is high, the pressure is low, and micro liquid drops are moved under the action of the Bernoulli effect.
2. The method for controlling microdroplets based on the photo-thermal effect as claimed in claim 1, wherein the method comprises the following steps: the wavelength of the output light of the laser is the corresponding wavelength with larger absorption coefficient of the liquid to be measured.
3. The method for controlling microdroplets based on the photo-thermal effect as claimed in claim 1, wherein the method comprises the following steps: the quantity and the size of the micro liquid drops and the distance from the liquid drops to the liquid to be measured are adjusted through the output power of the laser.
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| US20080105829A1 (en) * | 2004-01-23 | 2008-05-08 | Sri International | Apparatus and Method of Moving Micro-Droplets Using Laser-Induced Thermal Gradients |
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| CN109289948A (en) * | 2018-10-08 | 2019-02-01 | 重庆大学 | A kind of photo-thermal orientation manipulation drop migration polyplant and its application method |
| CN112216418A (en) * | 2020-08-31 | 2021-01-12 | 桂林电子科技大学 | Integrated single fiber droplet manipulator |
| CN113340693A (en) * | 2021-06-17 | 2021-09-03 | 重庆大学 | Photo-thermal control liquid drop three-dimensional migration device and using method |
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| US20080105829A1 (en) * | 2004-01-23 | 2008-05-08 | Sri International | Apparatus and Method of Moving Micro-Droplets Using Laser-Induced Thermal Gradients |
| CN108246372A (en) * | 2018-01-23 | 2018-07-06 | 河北工业大学 | A kind of reciprocal feeding device of real-time controllable microlayer model and method based on lithium niobate sandwich chip |
| CN109289948A (en) * | 2018-10-08 | 2019-02-01 | 重庆大学 | A kind of photo-thermal orientation manipulation drop migration polyplant and its application method |
| CN112216418A (en) * | 2020-08-31 | 2021-01-12 | 桂林电子科技大学 | Integrated single fiber droplet manipulator |
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