CN115715294A - 用于合成含硫醚肽的方法 - Google Patents

用于合成含硫醚肽的方法 Download PDF

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Publication number
CN115715294A
CN115715294A CN202180040700.1A CN202180040700A CN115715294A CN 115715294 A CN115715294 A CN 115715294A CN 202180040700 A CN202180040700 A CN 202180040700A CN 115715294 A CN115715294 A CN 115715294A
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CN
China
Prior art keywords
pro
gly
compound
indole
formula
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Pending
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CN202180040700.1A
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English (en)
Chinese (zh)
Inventor
H·格鲁斯
C·卢茨
R·苏斯穆特
姚贵阳
C·克尼特尔
S·科索尔
A·迈因茨
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Heidelberg Pharma Research GmbH
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Heidelberg Pharma Research GmbH
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Application filed by Heidelberg Pharma Research GmbH filed Critical Heidelberg Pharma Research GmbH
Publication of CN115715294A publication Critical patent/CN115715294A/zh
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/64—Cyclic peptides containing only normal peptide links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D209/20—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals substituted additionally by nitrogen atoms, e.g. tryptophane
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
    • C07K1/113—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Peptides Or Proteins (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
CN202180040700.1A 2020-06-09 2021-06-09 用于合成含硫醚肽的方法 Pending CN115715294A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP20178980.7 2020-06-09
EP20178980 2020-06-09
PCT/EP2021/065392 WO2021250059A1 (en) 2020-06-09 2021-06-09 Method for synthesis of thioether-containing peptides

Publications (1)

Publication Number Publication Date
CN115715294A true CN115715294A (zh) 2023-02-24

Family

ID=71083379

Family Applications (1)

Application Number Title Priority Date Filing Date
CN202180040700.1A Pending CN115715294A (zh) 2020-06-09 2021-06-09 用于合成含硫醚肽的方法

Country Status (5)

Country Link
US (1) US20230220001A1 (https=)
EP (1) EP4161946A1 (https=)
JP (1) JP2023529455A (https=)
CN (1) CN115715294A (https=)
WO (1) WO2021250059A1 (https=)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2024188373A3 (zh) * 2024-03-07 2025-01-09 内蒙古大学 L-6-羟基色氨酸衍生物及中间体的制备方法

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA3118031A1 (en) * 2018-12-11 2020-06-18 Heidelberg Pharma Research Gmbh Synthesis of (s)-6-hydroxytryptophan and derivatives thereof
EP4259643A4 (en) * 2020-12-08 2025-01-15 The University of British Columbia Amatoxin analogs and uses thereof

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2003514913A (ja) 1999-11-24 2003-04-22 マサチューセッツ インスティテュート オブ テクノロジー 多糖、天然生成物及びコンビナトリアル・ライブラリの合成に有用な保護基
US7964702B2 (en) * 2006-05-04 2011-06-21 The Regents Of The University Of California Phalloidin derivatives and methods for their synthesis
US8569452B2 (en) * 2011-02-17 2013-10-29 American Peptide Company, Inc. Preparation of phalloidin and its derivatives
JP6428604B2 (ja) 2013-04-04 2018-11-28 味の素株式会社 脱保護方法
EP3268047B9 (en) 2015-03-09 2024-01-10 Heidelberg Pharma Research GmbH Amatoxin-antibody conjugates
MX378847B (es) * 2015-11-27 2025-03-11 Heidelberg Pharma Res Gmbh Nuevos derivados de gamma-amanitina
EP3222292A1 (en) * 2016-03-03 2017-09-27 Heidelberg Pharma GmbH Amanitin conjugates
US10961277B2 (en) * 2017-08-07 2021-03-30 Heidelberg Pharma Research Gmbh Method for synthesizing amanitins
SG11202008017UA (en) * 2017-09-08 2020-09-29 Sichuan Baili Pharm Co Ltd Amanitin antibody conjugate
AU2019366960A1 (en) 2018-10-23 2021-05-27 Regeneron Pharmaceuticals, Inc. Fc silenced antibody drug conjugates (ADCs) and uses thereof
KR20220011640A (ko) 2019-05-23 2022-01-28 하이델베르크 파마 리서치 게엠베하 절단 가능한 링커를 가진 항체 약물 접합체

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2024188373A3 (zh) * 2024-03-07 2025-01-09 内蒙古大学 L-6-羟基色氨酸衍生物及中间体的制备方法

Also Published As

Publication number Publication date
JP2023529455A (ja) 2023-07-10
WO2021250059A1 (en) 2021-12-16
EP4161946A1 (en) 2023-04-12
US20230220001A1 (en) 2023-07-13

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