CN115698058A - 抗SARS-CoV-2刺突蛋白单克隆抗体 - Google Patents

抗SARS-CoV-2刺突蛋白单克隆抗体 Download PDF

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CN115698058A
CN115698058A CN202180036738.1A CN202180036738A CN115698058A CN 115698058 A CN115698058 A CN 115698058A CN 202180036738 A CN202180036738 A CN 202180036738A CN 115698058 A CN115698058 A CN 115698058A
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amino acid
seq
variable region
chain variable
acid sequence
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刘培
丁莉丹
阳露
陈晖�
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Nanjing Jinsirui Science and Technology Biology Corp
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Nanjing Jinsirui Science and Technology Biology Corp
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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/08Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
    • C07K16/10Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from RNA viruses
    • C07K16/1002Coronaviridae
    • C07K16/1003Severe acute respiratory syndrome coronavirus 2 [SARS‐CoV‐2 or Covid-19]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/42Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum viral
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/14Antivirals for RNA viruses
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/08Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
    • C07K16/10Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from RNA viruses
    • C07K16/1002Coronaviridae
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
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  • Hematology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biomedical Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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Abstract

涉及病毒检测诊断、治疗领域,具体涉及抗SARS‑CoV‑2刺突蛋白单克隆抗体及其制备方法和用途。提供了抗SARS‑CoV‑2刺突蛋白单克隆抗体、其重链可变区和轻链可变区的氨基酸序列。提供的抗SARS‑CoV‑2刺突蛋白单克隆抗体能够特异性地与S蛋白结合,能够有效地阻断S蛋白与ACE2蛋白的结合,特异性地阻止病毒感染人的细胞。提供的抗SARS‑CoV‑2刺突蛋白单克隆抗体为SARS‑CoV‑2病毒的治疗和检测提供了可能和便利。

Description

PCT国内申请,说明书已公开。

Claims (17)

  1. PCT国内申请,权利要求书已公开。
CN202180036738.1A 2020-05-22 2021-05-21 抗SARS-CoV-2刺突蛋白单克隆抗体 Pending CN115698058A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CN202010442784 2020-05-22
CN2020104427849 2020-05-22
PCT/CN2021/095228 WO2021233433A1 (zh) 2020-05-22 2021-05-21 抗SARS-CoV-2刺突蛋白单克隆抗体

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CN115698058A true CN115698058A (zh) 2023-02-03

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CN202180036738.1A Pending CN115698058A (zh) 2020-05-22 2021-05-21 抗SARS-CoV-2刺突蛋白单克隆抗体

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CN (1) CN115698058A (zh)
WO (1) WO2021233433A1 (zh)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN115960218B (zh) * 2022-09-30 2024-02-06 中国医学科学院病原生物学研究所 一种抗新型冠状病毒的抗体及其用途

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* Cited by examiner, † Cited by third party
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CN111153991A (zh) * 2020-02-26 2020-05-15 北京博奥森生物技术有限公司 一种人SARS-CoV-2单克隆抗体及其制备方法和应用

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