CN115666726A - 具有铰链结构域的人源化Notch受体 - Google Patents

具有铰链结构域的人源化Notch受体 Download PDF

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CN115666726A
CN115666726A CN202180039079.7A CN202180039079A CN115666726A CN 115666726 A CN115666726 A CN 115666726A CN 202180039079 A CN202180039079 A CN 202180039079A CN 115666726 A CN115666726 A CN 115666726A
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cells
cell
leu
chimeric polypeptide
gly
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K·T·罗伊鲍尔
R·刘
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University of California, San Diego
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CN202180039079.7A 2020-04-09 2021-04-08 具有铰链结构域的人源化Notch受体 Pending CN115666726A (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US202063007807P 2020-04-09 2020-04-09
US63/007,807 2020-04-09
US202163165588P 2021-03-24 2021-03-24
US63/165,588 2021-03-24
PCT/US2021/026430 WO2021207526A1 (en) 2020-04-09 2021-04-08 Humanized notch receptors with hinge domain

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US (1) US12662675B2 (enExample)
EP (1) EP4132659A4 (enExample)
JP (1) JP7863331B2 (enExample)
KR (1) KR20220166833A (enExample)
CN (1) CN115666726A (enExample)
AU (1) AU2021251212A1 (enExample)
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Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX2024003887A (es) 2021-10-14 2024-07-09 Arsenal Biosciences Inc Células inmunitarias que tienen arnch coespresados y sistemas de compuerta lógica.
TW202442689A (zh) 2023-03-03 2024-11-01 美商亞森諾生物科學公司 靶向ｐｓｍａ及ｃａ９之系統
EP4680748A1 (en) 2023-03-13 2026-01-21 Arsenal Biosciences, Inc. Synthetic pathway activators
EP4701654A2 (en) * 2023-04-25 2026-03-04 Arsenal Biosciences, Inc. Novel receptors for transcription regulation
WO2026055533A1 (en) * 2024-09-06 2026-03-12 The Regents Of The University Of California Synthetic receptors for engineered ligands

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2018039247A1 (en) * 2016-08-23 2018-03-01 The Regents Of The University Of California Proteolytically cleavable chimeric polypeptides and methods of use thereof
US20180355011A1 (en) * 2015-02-24 2018-12-13 The Regents Of The University Of California Binding-triggered transcriptional switches and methods of use thereof
US20180362603A1 (en) * 2017-06-19 2018-12-20 Cell Design Labs, Inc. Methods and compositions for reducing the immunogenicity of chimeric notch receptors
CN114761084A (zh) * 2019-09-24 2022-07-15 加利福尼亚大学董事会 具有铰链结构域的Notch受体

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6333167B1 (en) * 2000-03-10 2001-12-25 American Home Products Corp. Methods and reagents for identifying inhibitors of proteolysis of membrane-associated proteins
CN103502466A (zh) * 2010-09-07 2014-01-08 斯隆－凯特林纪念癌症中心 用于γ-分泌酶测定的方法和组合物
ES2769574T3 (es) * 2013-03-15 2020-06-26 Michael C Milone Reconocimiento de células citotóxicas con receptores quiméricos para inmunoterapia adoptiva
SG10201808811QA (en) 2014-04-10 2018-11-29 Seattle Childrens Hospital Dba Seattle Childrens Res Inst Method and compositions for cellular immunotherapy
CN115094062A (zh) 2015-04-16 2022-09-23 埃默里大学 用于肝脏中蛋白质表达的重组启动子和载体及其用途
JP2020532987A (ja) 2017-09-08 2020-11-19 ポセイダ セラピューティクス，インコーポレイティド キメラリガンド受容体（ｃｌｒ）介在性の条件遺伝子発現のための組成物および方法
KR102742741B1 (ko) 2017-10-18 2024-12-16 프레시전 인코포레이티드 스페이서를 포함하는 폴리펩타이드 조성물
WO2019217913A1 (en) 2018-05-10 2019-11-14 Sensei Biotherapeutics, Inc. Aspartate beta-hydroxylase chimeric antigen receptors and uses thereof
GB201818816D0 (en) 2018-11-19 2019-01-02 Synpromics Ltd Regulatory nucleic acid sequences
CA3120014A1 (en) 2018-11-19 2020-05-28 Uniqure Ip B.V. Liver-specific viral promoters and methods of using the same
WO2021061791A1 (en) 2019-09-24 2021-04-01 The Regents Of The University Of California Notch receptors with zinc finger-containing transcriptional effector
US20220372101A1 (en) 2019-09-24 2022-11-24 The Regents Of The University Of California Novel receptors having a heterologous stop transfer sequence for ligand-dependent transcriptional regulation
US20220340637A1 (en) 2019-09-24 2022-10-27 The Regents Of The University Of California Notch receptors with minimal linker
CN114728174A (zh) 2019-09-24 2022-07-08 加利福尼亚大学董事会 具有异源跨膜结构域的受体
AU2021256845A1 (en) 2020-04-14 2022-11-24 Eidgenössische Technische Hochschule Zürich Cell classifier circuits and methods of use thereof
WO2022117686A1 (en) 2020-12-01 2022-06-09 ETH Zürich Dna constructs comprising alternative promoters
WO2022140159A1 (en) 2020-12-24 2022-06-30 Kite Pharma, Inc. Prostate cancer chimeric antigen receptors

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20180355011A1 (en) * 2015-02-24 2018-12-13 The Regents Of The University Of California Binding-triggered transcriptional switches and methods of use thereof
WO2018039247A1 (en) * 2016-08-23 2018-03-01 The Regents Of The University Of California Proteolytically cleavable chimeric polypeptides and methods of use thereof
CN109843929A (zh) * 2016-08-23 2019-06-04 加利福尼亚大学董事会 蛋白水解可切割的嵌合多肽及其使用方法
US20180362603A1 (en) * 2017-06-19 2018-12-20 Cell Design Labs, Inc. Methods and compositions for reducing the immunogenicity of chimeric notch receptors
CN110753552A (zh) * 2017-06-19 2020-02-04 细胞设计实验室股份有限公司 用于降低嵌合Notch受体的免疫原性的方法和组合物
CN114761084A (zh) * 2019-09-24 2022-07-15 加利福尼亚大学董事会 具有铰链结构域的Notch受体

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
ZI-JIE YANG: "Engineering of an enhanced synthetic Notch receptor by reducing ligand-independent activation", 《 COMMUNICATIONS BIOLOGY》, 13 March 2020 (2020-03-13), pages 1 - 7 *
董杰: "优化CAR结构增强CAR-T细胞治疗的安全性和有效性", 《中国肿瘤生物治疗杂志》, vol. 25, no. 12, 31 December 2018 (2018-12-31), pages 1209 - 1217 *

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US12662675B2 (en) 2026-06-23
IL297092A (en) 2022-12-01
AU2021251212A1 (en) 2022-11-03
JP7863331B2 (ja) 2026-05-21
JP2023521147A (ja) 2023-05-23
BR112022020415A2 (pt) 2023-02-28
WO2021207526A1 (en) 2021-10-14
KR20220166833A (ko) 2022-12-19
CA3179954A1 (en) 2021-10-14
EP4132659A1 (en) 2023-02-15
EP4132659A4 (en) 2024-06-12
US20230183709A1 (en) 2023-06-15

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