CN115645612A

CN115645612A - 可注射细胞和支架组合物

可注射细胞和支架组合物 Download PDF

Info

Publication number: CN115645612A
Authority: CN; China
Prior art keywords: cells; cell; kidney; renal; population
Prior art date: 2017-03-31
Legal status : Pending

Application number

CN202210873005.XA

Other languages

English (en)

Chinese (zh)

Inventor

迪帕克.简

蒂莫西.A.伯特伦

Current Assignee

Prokidney Corp

Original Assignee

Individual

Priority date

2017-03-31

Filing date

2018-03-26

Publication date

2023-01-31

2018-03-26 Application filed by Individual filed Critical Individual

2023-01-31 Publication of CN115645612A publication Critical patent/CN115645612A/zh

Status Pending legal-status Critical Current

Links

239000000203 mixture Substances 0.000 title abstract description 296
230000000975 bioactive effect Effects 0.000 claims abstract description 101
210000004027 cell Anatomy 0.000 claims description 870
210000003292 kidney cell Anatomy 0.000 claims description 244
239000012620 biological material Substances 0.000 claims description 192
108010010803 Gelatin Proteins 0.000 claims description 135
229920000159 gelatin Polymers 0.000 claims description 135
239000008273 gelatin Substances 0.000 claims description 135
235000019322 gelatine Nutrition 0.000 claims description 135
235000011852 gelatine desserts Nutrition 0.000 claims description 135
210000003734 kidney Anatomy 0.000 claims description 112
210000001519 tissue Anatomy 0.000 claims description 95
239000011324 bead Substances 0.000 claims description 83
230000014509 gene expression Effects 0.000 claims description 68
241000282414 Homo sapiens Species 0.000 claims description 62
239000000017 hydrogel Substances 0.000 claims description 60
210000000056 organ Anatomy 0.000 claims description 54
239000007787 solid Substances 0.000 claims description 53
239000007972 injectable composition Substances 0.000 claims description 52
239000007788 liquid Substances 0.000 claims description 40
239000000499 gel Substances 0.000 claims description 33
108010035532 Collagen Proteins 0.000 claims description 29
102000008186 Collagen Human genes 0.000 claims description 29
229920001436 collagen Polymers 0.000 claims description 29
210000004926 tubular epithelial cell Anatomy 0.000 claims description 22
230000001413 cellular effect Effects 0.000 claims description 21
102000010834 Extracellular Matrix Proteins Human genes 0.000 claims description 18
108010037362 Extracellular Matrix Proteins Proteins 0.000 claims description 18
210000002744 extracellular matrix Anatomy 0.000 claims description 13
230000007704 transition Effects 0.000 claims description 11
230000000087 stabilizing effect Effects 0.000 claims description 10
239000006260 foam Substances 0.000 claims description 6
238000010899 nucleation Methods 0.000 claims description 2
238000009472 formulation Methods 0.000 abstract description 186
238000000034 method Methods 0.000 abstract description 123
239000013543 active substance Substances 0.000 abstract description 34
230000001225 therapeutic effect Effects 0.000 abstract description 26
239000000243 solution Substances 0.000 description 83
QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 54
229910052760 oxygen Inorganic materials 0.000 description 54
239000001301 oxygen Substances 0.000 description 54
KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 description 53
229920002674 hyaluronan Polymers 0.000 description 53
229960003160 hyaluronic acid Drugs 0.000 description 53
239000000047 product Substances 0.000 description 49
238000012384 transportation and delivery Methods 0.000 description 49
230000035899 viability Effects 0.000 description 43
108090000623 proteins and genes Proteins 0.000 description 42
208000017169 kidney disease Diseases 0.000 description 41
238000005119 centrifugation Methods 0.000 description 39
210000005084 renal tissue Anatomy 0.000 description 39
239000003795 chemical substances by application Substances 0.000 description 37
230000006870 function Effects 0.000 description 37
102000004169 proteins and genes Human genes 0.000 description 37
OXCMYAYHXIHQOA-UHFFFAOYSA-N potassium;[2-butyl-5-chloro-3-[[4-[2-(1,2,4-triaza-3-azanidacyclopenta-1,4-dien-5-yl)phenyl]phenyl]methyl]imidazol-4-yl]methanol Chemical compound [K+].CCCCC1=NC(Cl)=C(CO)N1CC1=CC=C(C=2C(=CC=CC=2)C2=N[N-]N=N2)C=C1 OXCMYAYHXIHQOA-UHFFFAOYSA-N 0.000 description 36
102000003951 Erythropoietin Human genes 0.000 description 35
108090000394 Erythropoietin Proteins 0.000 description 35
108010073929 Vascular Endothelial Growth Factor A Proteins 0.000 description 35
108010019530 Vascular Endothelial Growth Factors Proteins 0.000 description 35
229940105423 erythropoietin Drugs 0.000 description 35
102000005789 Vascular Endothelial Growth Factors Human genes 0.000 description 34
230000003907 kidney function Effects 0.000 description 34
230000001172 regenerating effect Effects 0.000 description 34
239000000523 sample Substances 0.000 description 34
230000003833 cell viability Effects 0.000 description 33
238000002513 implantation Methods 0.000 description 33
238000011282 treatment Methods 0.000 description 33
239000000463 material Substances 0.000 description 31
206010021143 Hypoxia Diseases 0.000 description 30
101710107035 Gamma-glutamyltranspeptidase Proteins 0.000 description 28
101710173228 Glutathione hydrolase proenzyme Proteins 0.000 description 28
102100034459 Hepatitis A virus cellular receptor 1 Human genes 0.000 description 28
101710185991 Hepatitis A virus cellular receptor 1 homolog Proteins 0.000 description 28
102000006640 gamma-Glutamyltransferase Human genes 0.000 description 28
230000001146 hypoxic effect Effects 0.000 description 27
238000003860 storage Methods 0.000 description 27
230000010261 cell growth Effects 0.000 description 26
230000004888 barrier function Effects 0.000 description 25
230000006872 improvement Effects 0.000 description 24
108010036221 Aquaporin 2 Proteins 0.000 description 23
238000011862 kidney biopsy Methods 0.000 description 23
102100034414 Aquaporin-2 Human genes 0.000 description 22
102000000905 Cadherin Human genes 0.000 description 22
108050007957 Cadherin Proteins 0.000 description 22
238000012512 characterization method Methods 0.000 description 22
230000001976 improved effect Effects 0.000 description 22
NBQNWMBBSKPBAY-UHFFFAOYSA-N iodixanol Chemical compound IC=1C(C(=O)NCC(O)CO)=C(I)C(C(=O)NCC(O)CO)=C(I)C=1N(C(=O)C)CC(O)CN(C(C)=O)C1=C(I)C(C(=O)NCC(O)CO)=C(I)C(C(=O)NCC(O)CO)=C1I NBQNWMBBSKPBAY-UHFFFAOYSA-N 0.000 description 22
102100033366 Glutathione hydrolase 1 proenzyme Human genes 0.000 description 21
239000011159 matrix material Substances 0.000 description 21
239000012591 Dulbecco’s Phosphate Buffered Saline Substances 0.000 description 20
230000002255 enzymatic effect Effects 0.000 description 20
238000002955 isolation Methods 0.000 description 20
238000000926 separation method Methods 0.000 description 20
210000000130 stem cell Anatomy 0.000 description 20
208000020832 chronic kidney disease Diseases 0.000 description 19
238000000338 in vitro Methods 0.000 description 19
238000004519 manufacturing process Methods 0.000 description 19
238000012544 monitoring process Methods 0.000 description 19
230000032258 transport Effects 0.000 description 19
-1 Ethylene oxide-polypropylene Chemical group 0.000 description 18
102000002704 Leucyl aminopeptidase Human genes 0.000 description 18
108010004098 Leucyl aminopeptidase Proteins 0.000 description 18
102100024616 Platelet endothelial cell adhesion molecule Human genes 0.000 description 18
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 18
238000001574 biopsy Methods 0.000 description 17
238000009826 distribution Methods 0.000 description 17
239000003814 drug Substances 0.000 description 17
238000001727 in vivo Methods 0.000 description 17
230000008929 regeneration Effects 0.000 description 17
238000011069 regeneration method Methods 0.000 description 17
230000006641 stabilisation Effects 0.000 description 17
238000011105 stabilization Methods 0.000 description 17
101000997558 Homo sapiens Glutathione hydrolase 1 proenzyme Proteins 0.000 description 16
238000004113 cell culture Methods 0.000 description 16
241000283690 Bos taurus Species 0.000 description 15
102100023972 Keratin, type II cytoskeletal 8 Human genes 0.000 description 15
210000002889 endothelial cell Anatomy 0.000 description 15
238000002347 injection Methods 0.000 description 15
239000007924 injection Substances 0.000 description 15
239000002609 medium Substances 0.000 description 15
102000005962 receptors Human genes 0.000 description 15
108020003175 receptors Proteins 0.000 description 15
210000005239 tubule Anatomy 0.000 description 15
241001465754 Metazoa Species 0.000 description 14
238000004458 analytical method Methods 0.000 description 14
239000000090 biomarker Substances 0.000 description 14
230000015572 biosynthetic process Effects 0.000 description 14
DDRJAANPRJIHGJ-UHFFFAOYSA-N creatinine Chemical compound CN1CC(=O)NC1=N DDRJAANPRJIHGJ-UHFFFAOYSA-N 0.000 description 14
229960004359 iodixanol Drugs 0.000 description 14
210000002220 organoid Anatomy 0.000 description 14
239000008188 pellet Substances 0.000 description 14
238000002360 preparation method Methods 0.000 description 14
210000000512 proximal kidney tubule Anatomy 0.000 description 14
239000000969 carrier Substances 0.000 description 13
230000003915 cell function Effects 0.000 description 13
230000000694 effects Effects 0.000 description 13
238000012360 testing method Methods 0.000 description 13
102000004190 Enzymes Human genes 0.000 description 12
108090000790 Enzymes Proteins 0.000 description 12
229940088598 enzyme Drugs 0.000 description 12
239000012530 fluid Substances 0.000 description 12
230000002829 reductive effect Effects 0.000 description 12
239000003963 antioxidant agent Substances 0.000 description 11
235000006708 antioxidants Nutrition 0.000 description 11
230000007547 defect Effects 0.000 description 11
201000010099 disease Diseases 0.000 description 11
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 11
230000003511 endothelial effect Effects 0.000 description 11
210000002919 epithelial cell Anatomy 0.000 description 11
230000001747 exhibiting effect Effects 0.000 description 11
239000003102 growth factor Substances 0.000 description 11
230000008884 pinocytosis Effects 0.000 description 11
230000008439 repair process Effects 0.000 description 11
210000002966 serum Anatomy 0.000 description 11
230000004083 survival effect Effects 0.000 description 11
101000998011 Homo sapiens Keratin, type I cytoskeletal 19 Proteins 0.000 description 10
102100033420 Keratin, type I cytoskeletal 19 Human genes 0.000 description 10
102000011782 Keratins Human genes 0.000 description 10
108010076876 Keratins Proteins 0.000 description 10
238000003556 assay Methods 0.000 description 10
238000012832 cell culture technique Methods 0.000 description 10
210000005257 cortical tissue Anatomy 0.000 description 10
238000000684 flow cytometry Methods 0.000 description 10
238000001943 fluorescence-activated cell sorting Methods 0.000 description 10
RWSXRVCMGQZWBV-WDSKDSINSA-N glutathione Chemical compound OC(=O)[C@@H](N)CCC(=O)N[C@@H](CS)C(=O)NCC(O)=O RWSXRVCMGQZWBV-WDSKDSINSA-N 0.000 description 10
230000002519 immonomodulatory effect Effects 0.000 description 10
229920000642 polymer Polymers 0.000 description 10
230000029663 wound healing Effects 0.000 description 10
108090001004 Aquaporin 1 Proteins 0.000 description 9
102000004888 Aquaporin 1 Human genes 0.000 description 9
102000003918 Hyaluronan Synthases Human genes 0.000 description 9
108090000320 Hyaluronan Synthases Proteins 0.000 description 9
239000002870 angiogenesis inducing agent Substances 0.000 description 9
239000000560 biocompatible material Substances 0.000 description 9
230000006041 cell recruitment Effects 0.000 description 9
230000006862 enzymatic digestion Effects 0.000 description 9
210000001339 epidermal cell Anatomy 0.000 description 9
210000001808 exosome Anatomy 0.000 description 9
239000006166 lysate Substances 0.000 description 9
210000002700 urine Anatomy 0.000 description 9
230000002792 vascular Effects 0.000 description 9
VYLJAYXZTOTZRR-BTPDVQIOSA-N CC(C)(O)[C@H]1CC[C@@]2(C)[C@H]1CC[C@]1(C)[C@@H]2CC[C@@H]2[C@@]3(C)CCCC(C)(C)[C@@H]3[C@@H](O)[C@H](O)[C@@]12C Chemical compound CC(C)(O)[C@H]1CC[C@@]2(C)[C@H]1CC[C@]1(C)[C@@H]2CC[C@@H]2[C@@]3(C)CCCC(C)(C)[C@@H]3[C@@H](O)[C@H](O)[C@@]12C VYLJAYXZTOTZRR-BTPDVQIOSA-N 0.000 description 8
102100023126 Cell surface glycoprotein MUC18 Human genes 0.000 description 8
101000623903 Homo sapiens Cell surface glycoprotein MUC18 Proteins 0.000 description 8
102100023195 Nephrin Human genes 0.000 description 8
208000027418 Wounds and injury Diseases 0.000 description 8
239000002260 anti-inflammatory agent Substances 0.000 description 8
229940121363 anti-inflammatory agent Drugs 0.000 description 8
230000008901 benefit Effects 0.000 description 8
150000001718 carbodiimides Chemical class 0.000 description 8
238000012258 culturing Methods 0.000 description 8
230000006378 damage Effects 0.000 description 8
230000003111 delayed effect Effects 0.000 description 8
230000001605 fetal effect Effects 0.000 description 8
VYLJAYXZTOTZRR-UHFFFAOYSA-N hopane-6alpha,7beta,22-triol Natural products C12CCC3C4(C)CCCC(C)(C)C4C(O)C(O)C3(C)C1(C)CCC1C2(C)CCC1C(C)(O)C VYLJAYXZTOTZRR-UHFFFAOYSA-N 0.000 description 8
208000014674 injury Diseases 0.000 description 8
230000010354 integration Effects 0.000 description 8
238000005259 measurement Methods 0.000 description 8
230000002503 metabolic effect Effects 0.000 description 8
230000004060 metabolic process Effects 0.000 description 8
108091070501 miRNA Proteins 0.000 description 8
239000002679 microRNA Substances 0.000 description 8
108010027531 nephrin Proteins 0.000 description 8
102000039446 nucleic acids Human genes 0.000 description 8
108020004707 nucleic acids Proteins 0.000 description 8
150000007523 nucleic acids Chemical class 0.000 description 8
230000010412 perfusion Effects 0.000 description 8
230000008569 process Effects 0.000 description 8
FPQQSJJWHUJYPU-UHFFFAOYSA-N 3-(dimethylamino)propyliminomethylidene-ethylazanium;chloride Chemical compound Cl.CCN=C=NCCCN(C)C FPQQSJJWHUJYPU-UHFFFAOYSA-N 0.000 description 7
102000010637 Aquaporins Human genes 0.000 description 7
108010063290 Aquaporins Proteins 0.000 description 7
102100031650 C-X-C chemokine receptor type 4 Human genes 0.000 description 7
101000922348 Homo sapiens C-X-C chemokine receptor type 4 Proteins 0.000 description 7
108010015372 Low Density Lipoprotein Receptor-Related Protein-2 Proteins 0.000 description 7
102100021922 Low-density lipoprotein receptor-related protein 2 Human genes 0.000 description 7
239000012124 Opti-MEM Substances 0.000 description 7
102100036037 Podocin Human genes 0.000 description 7
101710162479 Podocin Proteins 0.000 description 7
230000002776 aggregation Effects 0.000 description 7
238000004220 aggregation Methods 0.000 description 7
239000006285 cell suspension Substances 0.000 description 7
239000003153 chemical reaction reagent Substances 0.000 description 7
239000003636 conditioned culture medium Substances 0.000 description 7
238000001816 cooling Methods 0.000 description 7
229940109239 creatinine Drugs 0.000 description 7
108010039433 dolichos biflorus agglutinin Proteins 0.000 description 7
229940079593 drug Drugs 0.000 description 7
239000000284 extract Substances 0.000 description 7
238000011223 gene expression profiling Methods 0.000 description 7
230000024924 glomerular filtration Effects 0.000 description 7
230000001817 pituitary effect Effects 0.000 description 7
125000006850 spacer group Chemical group 0.000 description 7
238000003211 trypan blue cell staining Methods 0.000 description 7
239000004971 Cross linker Substances 0.000 description 6
108050000637 N-cadherin Proteins 0.000 description 6
206010061481 Renal injury Diseases 0.000 description 6
GLNADSQYFUSGOU-GPTZEZBUSA-J Trypan blue Chemical compound [Na+].[Na+].[Na+].[Na+].C1=C(S([O-])(=O)=O)C=C2C=C(S([O-])(=O)=O)C(/N=N/C3=CC=C(C=C3C)C=3C=C(C(=CC=3)\N=N\C=3C(=CC4=CC(=CC(N)=C4C=3O)S([O-])(=O)=O)S([O-])(=O)=O)C)=C(O)C2=C1N GLNADSQYFUSGOU-GPTZEZBUSA-J 0.000 description 6
230000000735 allogeneic effect Effects 0.000 description 6
238000013459 approach Methods 0.000 description 6
208000022831 chronic renal failure syndrome Diseases 0.000 description 6
230000007423 decrease Effects 0.000 description 6
230000001419 dependent effect Effects 0.000 description 6
239000006185 dispersion Substances 0.000 description 6
230000012010 growth Effects 0.000 description 6
229960003444 immunosuppressant agent Drugs 0.000 description 6
239000003018 immunosuppressive agent Substances 0.000 description 6
239000003550 marker Substances 0.000 description 6
239000002245 particle Substances 0.000 description 6
230000004044 response Effects 0.000 description 6
210000002536 stromal cell Anatomy 0.000 description 6
238000002054 transplantation Methods 0.000 description 6
210000005167 vascular cell Anatomy 0.000 description 6
208000009304 Acute Kidney Injury Diseases 0.000 description 5
OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 5
QOSSAOTZNIDXMA-UHFFFAOYSA-N Dicylcohexylcarbodiimide Chemical compound C1CCCCC1N=C=NC1CCCCC1 QOSSAOTZNIDXMA-UHFFFAOYSA-N 0.000 description 5
108010024636 Glutathione Proteins 0.000 description 5
101710205562 Glutathione hydrolase 1 proenzyme Proteins 0.000 description 5
102100037877 Intercellular adhesion molecule 1 Human genes 0.000 description 5
102100023974 Keratin, type II cytoskeletal 7 Human genes 0.000 description 5
WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 description 5
241000124008 Mammalia Species 0.000 description 5
101150044441 PECAM1 gene Proteins 0.000 description 5
238000011529 RT qPCR Methods 0.000 description 5
208000033626 Renal failure acute Diseases 0.000 description 5
201000011040 acute kidney failure Diseases 0.000 description 5
235000010443 alginic acid Nutrition 0.000 description 5
229920000615 alginic acid Polymers 0.000 description 5
230000000890 antigenic effect Effects 0.000 description 5
230000027455 binding Effects 0.000 description 5
230000004071 biological effect Effects 0.000 description 5
210000004369 blood Anatomy 0.000 description 5
239000008280 blood Substances 0.000 description 5
229910052791 calcium Inorganic materials 0.000 description 5
239000011575 calcium Substances 0.000 description 5
230000021164 cell adhesion Effects 0.000 description 5
238000004132 cross linking Methods 0.000 description 5
230000007515 enzymatic degradation Effects 0.000 description 5
235000003969 glutathione Nutrition 0.000 description 5
229960003180 glutathione Drugs 0.000 description 5
230000004807 localization Effects 0.000 description 5
210000002901 mesenchymal stem cell Anatomy 0.000 description 5
230000004048 modification Effects 0.000 description 5
238000012986 modification Methods 0.000 description 5
150000003141 primary amines Chemical class 0.000 description 5
238000005057 refrigeration Methods 0.000 description 5
238000011808 rodent model Methods 0.000 description 5
238000004062 sedimentation Methods 0.000 description 5
239000000758 substrate Substances 0.000 description 5
239000000725 suspension Substances 0.000 description 5
IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 4
108091003079 Bovine Serum Albumin Proteins 0.000 description 4
108010044214 Class 3 Receptor-Like Protein Tyrosine Phosphatases Proteins 0.000 description 4
102000004127 Cytokines Human genes 0.000 description 4
108090000695 Cytokines Proteins 0.000 description 4
208000007342 Diabetic Nephropathies Diseases 0.000 description 4
239000006144 Dulbecco’s modiﬁed Eagle's medium Substances 0.000 description 4
101000610551 Homo sapiens Prominin-1 Proteins 0.000 description 4
ROHFNLRQFUQHCH-YFKPBYRVSA-N L-leucine Chemical compound CC(C)C[C@H](N)C(O)=O ROHFNLRQFUQHCH-YFKPBYRVSA-N 0.000 description 4
108010052285 Membrane Proteins Proteins 0.000 description 4
102000009664 Microtubule-Associated Proteins Human genes 0.000 description 4
108010020004 Microtubule-Associated Proteins Proteins 0.000 description 4
108010069381 Platelet Endothelial Cell Adhesion Molecule-1 Proteins 0.000 description 4
102100036031 Podocalyxin Human genes 0.000 description 4
102100040120 Prominin-1 Human genes 0.000 description 4
102100034086 Receptor-type tyrosine-protein phosphatase O Human genes 0.000 description 4
102100036930 Solute carrier family 22 member 6 Human genes 0.000 description 4
101710102683 Solute carrier family 22 member 6 Proteins 0.000 description 4
210000001744 T-lymphocyte Anatomy 0.000 description 4
108010027007 Uromodulin Proteins 0.000 description 4
102000018614 Uromodulin Human genes 0.000 description 4
108010053099 Vascular Endothelial Growth Factor Receptor-2 Proteins 0.000 description 4
238000002835 absorbance Methods 0.000 description 4
230000009471 action Effects 0.000 description 4
208000012998 acute renal failure Diseases 0.000 description 4
208000007502 anemia Diseases 0.000 description 4
230000033115 angiogenesis Effects 0.000 description 4
210000004204 blood vessel Anatomy 0.000 description 4
210000001124 body fluid Anatomy 0.000 description 4
210000000988 bone and bone Anatomy 0.000 description 4
210000000845 cartilage Anatomy 0.000 description 4
239000006143 cell culture medium Substances 0.000 description 4
210000000170 cell membrane Anatomy 0.000 description 4
230000008859 change Effects 0.000 description 4
238000004624 confocal microscopy Methods 0.000 description 4
239000003431 cross linking reagent Substances 0.000 description 4
238000005138 cryopreservation Methods 0.000 description 4
210000004748 cultured cell Anatomy 0.000 description 4
230000007812 deficiency Effects 0.000 description 4
230000002950 deficient Effects 0.000 description 4
238000001514 detection method Methods 0.000 description 4
238000011161 development Methods 0.000 description 4
230000018109 developmental process Effects 0.000 description 4
208000033679 diabetic kidney disease Diseases 0.000 description 4
230000004069 differentiation Effects 0.000 description 4
210000000981 epithelium Anatomy 0.000 description 4
230000007717 exclusion Effects 0.000 description 4
230000002349 favourable effect Effects 0.000 description 4
239000012091 fetal bovine serum Substances 0.000 description 4
238000001879 gelation Methods 0.000 description 4
150000004676 glycans Chemical class 0.000 description 4
230000013632 homeostatic process Effects 0.000 description 4
239000001257 hydrogen Substances 0.000 description 4
229910052739 hydrogen Inorganic materials 0.000 description 4
239000003446 ligand Substances 0.000 description 4
230000000670 limiting effect Effects 0.000 description 4
239000012528 membrane Substances 0.000 description 4
230000005012 migration Effects 0.000 description 4
238000013508 migration Methods 0.000 description 4
239000012071 phase Substances 0.000 description 4
239000002953 phosphate buffered saline Substances 0.000 description 4
229920001282 polysaccharide Polymers 0.000 description 4
239000005017 polysaccharide Substances 0.000 description 4
108090000765 processed proteins & peptides Proteins 0.000 description 4
238000004393 prognosis Methods 0.000 description 4
230000035755 proliferation Effects 0.000 description 4
230000035945 sensitivity Effects 0.000 description 4
239000000126 substance Substances 0.000 description 4
210000002435 tendon Anatomy 0.000 description 4
229940124597 therapeutic agent Drugs 0.000 description 4
238000002560 therapeutic procedure Methods 0.000 description 4
108091032973 (ribonucleotides)n+m Proteins 0.000 description 3
FHVDTGUDJYJELY-UHFFFAOYSA-N 6-{[2-carboxy-4,5-dihydroxy-6-(phosphanyloxy)oxan-3-yl]oxy}-4,5-dihydroxy-3-phosphanyloxane-2-carboxylic acid Chemical compound O1C(C(O)=O)C(P)C(O)C(O)C1OC1C(C(O)=O)OC(OP)C(O)C1O FHVDTGUDJYJELY-UHFFFAOYSA-N 0.000 description 3
102000007469 Actins Human genes 0.000 description 3
108010085238 Actins Proteins 0.000 description 3
108010088751 Albumins Proteins 0.000 description 3
102000009027 Albumins Human genes 0.000 description 3
102100034608 Angiopoietin-2 Human genes 0.000 description 3
108010048036 Angiopoietin-2 Proteins 0.000 description 3
108010036280 Aquaporin 4 Proteins 0.000 description 3
102100037276 Aquaporin-4 Human genes 0.000 description 3
IYMAXBFPHPZYIK-BQBZGAKWSA-N Arg-Gly-Asp Chemical compound NC(N)=NCCC[C@H](N)C(=O)NCC(=O)N[C@@H](CC(O)=O)C(O)=O IYMAXBFPHPZYIK-BQBZGAKWSA-N 0.000 description 3
108010061299 CXCR4 Receptors Proteins 0.000 description 3
102000012000 CXCR4 Receptors Human genes 0.000 description 3
241000282465 Canis Species 0.000 description 3
241001631457 Cannula Species 0.000 description 3
101100372758 Danio rerio vegfaa gene Proteins 0.000 description 3
108010013198 Daptomycin Proteins 0.000 description 3
206010016654 Fibrosis Diseases 0.000 description 3
102000006395 Globulins Human genes 0.000 description 3
108010044091 Globulins Proteins 0.000 description 3
WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 3
101000884271 Homo sapiens Signal transducer CD24 Proteins 0.000 description 3
101000617130 Homo sapiens Stromal cell-derived factor 1 Proteins 0.000 description 3
206010020772 Hypertension Diseases 0.000 description 3
DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical group C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 3
206010061218 Inflammation Diseases 0.000 description 3
108010064593 Intercellular Adhesion Molecule-1 Proteins 0.000 description 3
101100352764 Mus musculus Podn gene Proteins 0.000 description 3
108091005461 Nucleic proteins Proteins 0.000 description 3
102000004264 Osteopontin Human genes 0.000 description 3
108010081689 Osteopontin Proteins 0.000 description 3
MUBZPKHOEPUJKR-UHFFFAOYSA-N Oxalic acid Chemical compound OC(=O)C(O)=O MUBZPKHOEPUJKR-UHFFFAOYSA-N 0.000 description 3
OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 description 3
239000004698 Polyethylene Substances 0.000 description 3
208000001647 Renal Insufficiency Diseases 0.000 description 3
108010071390 Serum Albumin Proteins 0.000 description 3
102000007562 Serum Albumin Human genes 0.000 description 3
102100038081 Signal transducer CD24 Human genes 0.000 description 3
FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 3
102100021669 Stromal cell-derived factor 1 Human genes 0.000 description 3
102000004887 Transforming Growth Factor beta Human genes 0.000 description 3
108090001012 Transforming Growth Factor beta Proteins 0.000 description 3
101150030763 Vegfa gene Proteins 0.000 description 3
QYSXJUFSXHHAJI-XFEUOLMDSA-N Vitamin D3 Natural products C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C/C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-XFEUOLMDSA-N 0.000 description 3
PNNCWTXUWKENPE-UHFFFAOYSA-N [N].NC(N)=O Chemical compound [N].NC(N)=O PNNCWTXUWKENPE-UHFFFAOYSA-N 0.000 description 3
229940072056 alginate Drugs 0.000 description 3
WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 3
239000012867 bioactive agent Substances 0.000 description 3
239000012472 biological sample Substances 0.000 description 3
229920001400 block copolymer Polymers 0.000 description 3
239000010839 body fluid Substances 0.000 description 3
102000014823 calbindin Human genes 0.000 description 3
108060001061 calbindin Proteins 0.000 description 3
239000002775 capsule Substances 0.000 description 3
230000015556 catabolic process Effects 0.000 description 3
230000004663 cell proliferation Effects 0.000 description 3
HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 3
150000001875 compounds Chemical class 0.000 description 3
210000002808 connective tissue Anatomy 0.000 description 3
239000013068 control sample Substances 0.000 description 3
229940021392 cubicin Drugs 0.000 description 3
DOAKLVKFURWEDJ-QCMAZARJSA-N daptomycin Chemical compound C([C@H]1C(=O)O[C@H](C)[C@@H](C(NCC(=O)N[C@@H](CCCN)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@H](C)C(=O)N[C@@H](CC(O)=O)C(=O)NCC(=O)N[C@H](CO)C(=O)N[C@H](C(=O)N1)[C@H](C)CC(O)=O)=O)NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H](CC(N)=O)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)CCCCCCCCC)C(=O)C1=CC=CC=C1N DOAKLVKFURWEDJ-QCMAZARJSA-N 0.000 description 3
238000006731 degradation reaction Methods 0.000 description 3
238000000432 density-gradient centrifugation Methods 0.000 description 3
238000000151 deposition Methods 0.000 description 3
230000001079 digestive effect Effects 0.000 description 3
239000003623 enhancer Substances 0.000 description 3
210000003743 erythrocyte Anatomy 0.000 description 3
230000000925 erythroid effect Effects 0.000 description 3
238000011156 evaluation Methods 0.000 description 3
230000004761 fibrosis Effects 0.000 description 3
239000012467 final product Substances 0.000 description 3
102000034356 gene-regulatory proteins Human genes 0.000 description 3
210000003904 glomerular cell Anatomy 0.000 description 3
239000001963 growth medium Substances 0.000 description 3
230000036541 health Effects 0.000 description 3
239000008241 heterogeneous mixture Substances 0.000 description 3
108091008044 human SRC Proteins 0.000 description 3
230000006698 induction Effects 0.000 description 3
230000004054 inflammatory process Effects 0.000 description 3
239000004615 ingredient Substances 0.000 description 3
238000003780 insertion Methods 0.000 description 3
230000037431 insertion Effects 0.000 description 3
108010003082 intrinsic factor-cobalamin receptor Proteins 0.000 description 3
201000006370 kidney failure Diseases 0.000 description 3
239000010410 layer Substances 0.000 description 3
239000007791 liquid phase Substances 0.000 description 3
210000004962 mammalian cell Anatomy 0.000 description 3
230000007246 mechanism Effects 0.000 description 3
210000004379 membrane Anatomy 0.000 description 3
210000003205 muscle Anatomy 0.000 description 3
210000000885 nephron Anatomy 0.000 description 3
235000015097 nutrients Nutrition 0.000 description 3
229950011087 perflunafene Drugs 0.000 description 3
UWEYRJFJVCLAGH-IJWZVTFUSA-N perfluorodecalin Chemical compound FC1(F)C(F)(F)C(F)(F)C(F)(F)[C@@]2(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)[C@@]21F UWEYRJFJVCLAGH-IJWZVTFUSA-N 0.000 description 3
239000008194 pharmaceutical composition Substances 0.000 description 3
229910052698 phosphorus Inorganic materials 0.000 description 3
239000011574 phosphorus Substances 0.000 description 3
229920000573 polyethylene Polymers 0.000 description 3
239000004626 polylactic acid Substances 0.000 description 3
239000011148 porous material Substances 0.000 description 3
102000004196 processed proteins & peptides Human genes 0.000 description 3
230000000750 progressive effect Effects 0.000 description 3
238000011084 recovery Methods 0.000 description 3
230000009467 reduction Effects 0.000 description 3
230000004043 responsiveness Effects 0.000 description 3
238000005070 sampling Methods 0.000 description 3
230000028327 secretion Effects 0.000 description 3
230000011664 signaling Effects 0.000 description 3
210000003491 skin Anatomy 0.000 description 3
239000011734 sodium Substances 0.000 description 3
229910052708 sodium Inorganic materials 0.000 description 3
239000011780 sodium chloride Substances 0.000 description 3
239000007790 solid phase Substances 0.000 description 3
238000010561 standard procedure Methods 0.000 description 3
ZRKFYGHZFMAOKI-QMGMOQQFSA-N tgfbeta Chemical compound C([C@H](NC(=O)[C@H](C(C)C)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)CCSC)C(C)C)[C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](C)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N1[C@@H](CCC1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(O)=O)C1=CC=C(O)C=C1 ZRKFYGHZFMAOKI-QMGMOQQFSA-N 0.000 description 3
230000006711 vascular endothelial growth factor production Effects 0.000 description 3
238000005406 washing Methods 0.000 description 3
GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 description 2
BDNKZNFMNDZQMI-UHFFFAOYSA-N 1,3-diisopropylcarbodiimide Chemical compound CC(C)N=C=NC(C)C BDNKZNFMNDZQMI-UHFFFAOYSA-N 0.000 description 2
JCAULFRGWRHHIG-UHFFFAOYSA-N 1-bromo-1,1,2,2,3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,10-henicosafluorodecane Chemical compound FC(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)Br JCAULFRGWRHHIG-UHFFFAOYSA-N 0.000 description 2
QLHLYJHNOCILIT-UHFFFAOYSA-N 4-o-(2,5-dioxopyrrolidin-1-yl) 1-o-[2-[4-(2,5-dioxopyrrolidin-1-yl)oxy-4-oxobutanoyl]oxyethyl] butanedioate Chemical compound O=C1CCC(=O)N1OC(=O)CCC(=O)OCCOC(=O)CCC(=O)ON1C(=O)CCC1=O QLHLYJHNOCILIT-UHFFFAOYSA-N 0.000 description 2
102100022464 5'-nucleotidase Human genes 0.000 description 2
108010005465 AC133 Antigen Proteins 0.000 description 2
102000005908 AC133 Antigen Human genes 0.000 description 2
101150111620 AQP1 gene Proteins 0.000 description 2
101150047512 AQP2 gene Proteins 0.000 description 2
HGINCPLSRVDWNT-UHFFFAOYSA-N Acrolein Chemical compound C=CC=O HGINCPLSRVDWNT-UHFFFAOYSA-N 0.000 description 2
102100026609 Aldehyde dehydrogenase family 3 member B1 Human genes 0.000 description 2
101150115490 Aldh1a3 gene Proteins 0.000 description 2
101150012645 Aldh3b1 gene Proteins 0.000 description 2
CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 2
BPYKTIZUTYGOLE-IFADSCNNSA-N Bilirubin Chemical compound N1C(=O)C(C)=C(C=C)\C1=C\C1=C(C)C(CCC(O)=O)=C(CC2=C(C(C)=C(\C=C/3C(=C(C=C)C(=O)N\3)C)N2)CCC(O)=O)N1 BPYKTIZUTYGOLE-IFADSCNNSA-N 0.000 description 2
102100021943 C-C motif chemokine 2 Human genes 0.000 description 2
101710155857 C-C motif chemokine 2 Proteins 0.000 description 2
101150059114 CAPN8 gene Proteins 0.000 description 2
101150066398 CXCR4 gene Proteins 0.000 description 2
102100036364 Cadherin-2 Human genes 0.000 description 2
102000007590 Calpain Human genes 0.000 description 2
108010032088 Calpain Proteins 0.000 description 2
241000282472 Canis lupus familiaris Species 0.000 description 2
102000003780 Clusterin Human genes 0.000 description 2
108090000197 Clusterin Proteins 0.000 description 2
ACTIUHUUMQJHFO-UHFFFAOYSA-N Coenzym Q10 Natural products COC1=C(OC)C(=O)C(CC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)C)=C(C)C1=O ACTIUHUUMQJHFO-UHFFFAOYSA-N 0.000 description 2
102000001045 Connexin 43 Human genes 0.000 description 2
108010069241 Connexin 43 Proteins 0.000 description 2
102100031096 Cubilin Human genes 0.000 description 2
RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 2
206010061818 Disease progression Diseases 0.000 description 2
KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 description 2
101150043640 FXYD4 gene Proteins 0.000 description 2
102000016359 Fibronectins Human genes 0.000 description 2
108010067306 Fibronectins Proteins 0.000 description 2
108010070675 Glutathione transferase Proteins 0.000 description 2
102100029100 Hematopoietic prostaglandin D synthase Human genes 0.000 description 2
101000678236 Homo sapiens 5'-nucleotidase Proteins 0.000 description 2
101000717973 Homo sapiens Aldehyde dehydrogenase family 3 member B1 Proteins 0.000 description 2
101000714537 Homo sapiens Cadherin-2 Proteins 0.000 description 2
101000599852 Homo sapiens Intercellular adhesion molecule 1 Proteins 0.000 description 2
101001008874 Homo sapiens Mast/stem cell growth factor receptor Kit Proteins 0.000 description 2
101000595198 Homo sapiens Podocalyxin Proteins 0.000 description 2
101000620589 Homo sapiens Ras-related protein Rab-17 Proteins 0.000 description 2
101000819111 Homo sapiens Trans-acting T-cell-specific transcription factor GATA-3 Proteins 0.000 description 2
101000855326 Homo sapiens Vitamin D 25-hydroxylase Proteins 0.000 description 2
MHAJPDPJQMAIIY-UHFFFAOYSA-N Hydrogen peroxide Chemical compound OO MHAJPDPJQMAIIY-UHFFFAOYSA-N 0.000 description 2
108060003951 Immunoglobulin Proteins 0.000 description 2
102000004889 Interleukin-6 Human genes 0.000 description 2
108090001005 Interleukin-6 Proteins 0.000 description 2
ZDXPYRJPNDTMRX-VKHMYHEASA-N L-glutamine Chemical compound OC(=O)[C@@H](N)CCC(N)=O ZDXPYRJPNDTMRX-VKHMYHEASA-N 0.000 description 2
239000004395 L-leucine Substances 0.000 description 2
235000019454 L-leucine Nutrition 0.000 description 2
102000007547 Laminin Human genes 0.000 description 2
108010085895 Laminin Proteins 0.000 description 2
108090001090 Lectins Proteins 0.000 description 2
102000004856 Lectins Human genes 0.000 description 2
102100027754 Mast/stem cell growth factor receptor Kit Human genes 0.000 description 2
102000000380 Matrix Metalloproteinase 1 Human genes 0.000 description 2
108010016113 Matrix Metalloproteinase 1 Proteins 0.000 description 2
102000000424 Matrix Metalloproteinase 2 Human genes 0.000 description 2
108010016165 Matrix Metalloproteinase 2 Proteins 0.000 description 2
102000002274 Matrix Metalloproteinases Human genes 0.000 description 2
108010000684 Matrix Metalloproteinases Proteins 0.000 description 2
102000001776 Matrix metalloproteinase-9 Human genes 0.000 description 2
108010015302 Matrix metalloproteinase-9 Proteins 0.000 description 2
102000015728 Mucins Human genes 0.000 description 2
108010063954 Mucins Proteins 0.000 description 2
101100382351 Mus musculus Capn10 gene Proteins 0.000 description 2
101100013967 Mus musculus Gata3 gene Proteins 0.000 description 2
206010029113 Neovascularisation Diseases 0.000 description 2
208000008589 Obesity Diseases 0.000 description 2
241000283973 Oryctolagus cuniculus Species 0.000 description 2
108010022233 Plasminogen Activator Inhibitor 1 Proteins 0.000 description 2
102100039418 Plasminogen activator inhibitor 1 Human genes 0.000 description 2
101710204736 Platelet endothelial cell adhesion molecule Proteins 0.000 description 2
239000004793 Polystyrene Substances 0.000 description 2
REFJWTPEDVJJIY-UHFFFAOYSA-N Quercetin Chemical compound C=1C(O)=CC(O)=C(C(C=2O)=O)C=1OC=2C1=CC=C(O)C(O)=C1 REFJWTPEDVJJIY-UHFFFAOYSA-N 0.000 description 2
102100022292 Ras-related protein Rab-17 Human genes 0.000 description 2
108091006207 SLC-Transporter Proteins 0.000 description 2
102000037054 SLC-Transporter Human genes 0.000 description 2
108091006647 SLC9A1 Proteins 0.000 description 2
101150104588 Slc9a4 gene Proteins 0.000 description 2
101100497132 Sus scrofa CYP2D25 gene Proteins 0.000 description 2
101710119889 Synaptopodin Proteins 0.000 description 2
102100035604 Synaptopodin Human genes 0.000 description 2
IQFYYKKMVGJFEH-XLPZGREQSA-N Thymidine Chemical compound O=C1NC(=O)C(C)=CN1[C@@H]1O[C@H](CO)[C@@H](O)C1 IQFYYKKMVGJFEH-XLPZGREQSA-N 0.000 description 2
102000003978 Tissue Plasminogen Activator Human genes 0.000 description 2
108090000373 Tissue Plasminogen Activator Proteins 0.000 description 2
102100021386 Trans-acting T-cell-specific transcription factor GATA-3 Human genes 0.000 description 2
102000004338 Transferrin Human genes 0.000 description 2
108090000901 Transferrin Proteins 0.000 description 2
102000014456 Trefoil Factor-3 Human genes 0.000 description 2
108010078184 Trefoil Factor-3 Proteins 0.000 description 2
102000004142 Trypsin Human genes 0.000 description 2
108090000631 Trypsin Proteins 0.000 description 2
108060008682 Tumor Necrosis Factor Proteins 0.000 description 2
102000000852 Tumor Necrosis Factor-alpha Human genes 0.000 description 2
102100026523 Vitamin D 25-hydroxylase Human genes 0.000 description 2
238000010521 absorption reaction Methods 0.000 description 2
230000002411 adverse Effects 0.000 description 2
ANVAOWXLWRTKGA-XHGAXZNDSA-N all-trans-alpha-carotene Chemical compound CC=1CCCC(C)(C)C=1/C=C/C(/C)=C/C=C/C(/C)=C/C=C/C=C(C)C=CC=C(C)C=CC1C(C)=CCCC1(C)C ANVAOWXLWRTKGA-XHGAXZNDSA-N 0.000 description 2
150000001412 amines Chemical class 0.000 description 2
229940024606 amino acid Drugs 0.000 description 2
150000001413 amino acids Chemical class 0.000 description 2
239000007640 basal medium Substances 0.000 description 2
210000002469 basement membrane Anatomy 0.000 description 2
230000033228 biological regulation Effects 0.000 description 2
230000002051 biphasic effect Effects 0.000 description 2
NXVYSVARUKNFNF-UHFFFAOYSA-N bis(2,5-dioxopyrrolidin-1-yl) 2,3-dihydroxybutanedioate Chemical compound O=C1CCC(=O)N1OC(=O)C(O)C(O)C(=O)ON1C(=O)CCC1=O NXVYSVARUKNFNF-UHFFFAOYSA-N 0.000 description 2
LNQHREYHFRFJAU-UHFFFAOYSA-N bis(2,5-dioxopyrrolidin-1-yl) pentanedioate Chemical compound O=C1CCC(=O)N1OC(=O)CCCC(=O)ON1C(=O)CCC1=O LNQHREYHFRFJAU-UHFFFAOYSA-N 0.000 description 2
VYLDEYYOISNGST-UHFFFAOYSA-N bissulfosuccinimidyl suberate Chemical compound O=C1C(S(=O)(=O)O)CC(=O)N1OC(=O)CCCCCCC(=O)ON1C(=O)C(S(O)(=O)=O)CC1=O VYLDEYYOISNGST-UHFFFAOYSA-N 0.000 description 2
230000036772 blood pressure Effects 0.000 description 2
239000001045 blue dye Substances 0.000 description 2
210000001185 bone marrow Anatomy 0.000 description 2
239000000872 buffer Substances 0.000 description 2
102000006783 calponin Human genes 0.000 description 2
108010086826 calponin Proteins 0.000 description 2
235000021466 carotenoid Nutrition 0.000 description 2
150000001747 carotenoids Chemical class 0.000 description 2
238000005266 casting Methods 0.000 description 2
229920002678 cellulose Polymers 0.000 description 2
239000013043 chemical agent Substances 0.000 description 2
238000006243 chemical reaction Methods 0.000 description 2
235000017471 coenzyme Q10 Nutrition 0.000 description 2
ACTIUHUUMQJHFO-UPTCCGCDSA-N coenzyme Q10 Chemical compound COC1=C(OC)C(=O)C(C\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CCC=C(C)C)=C(C)C1=O ACTIUHUUMQJHFO-UPTCCGCDSA-N 0.000 description 2
239000002299 complementary DNA Substances 0.000 description 2
238000013270 controlled release Methods 0.000 description 2
VFLDPWHFBUODDF-FCXRPNKRSA-N curcumin Chemical compound C1=C(O)C(OC)=CC(\C=C\C(=O)CC(=O)\C=C\C=2C=C(OC)C(O)=CC=2)=C1 VFLDPWHFBUODDF-FCXRPNKRSA-N 0.000 description 2
230000003247 decreasing effect Effects 0.000 description 2
230000008021 deposition Effects 0.000 description 2
239000003599 detergent Substances 0.000 description 2
206010012601 diabetes mellitus Diseases 0.000 description 2
238000000502 dialysis Methods 0.000 description 2
230000005750 disease progression Effects 0.000 description 2
ZWIBGKZDAWNIFC-UHFFFAOYSA-N disuccinimidyl suberate Chemical compound O=C1CCC(=O)N1OC(=O)CCCCCCC(=O)ON1C(=O)CCC1=O ZWIBGKZDAWNIFC-UHFFFAOYSA-N 0.000 description 2
239000003937 drug carrier Substances 0.000 description 2
239000000975 dye Substances 0.000 description 2
230000002124 endocrine Effects 0.000 description 2
210000003890 endocrine cell Anatomy 0.000 description 2
230000007705 epithelial mesenchymal transition Effects 0.000 description 2
238000002474 experimental method Methods 0.000 description 2
238000010195 expression analysis Methods 0.000 description 2
239000013604 expression vector Substances 0.000 description 2
238000001914 filtration Methods 0.000 description 2
HYBBIBNJHNGZAN-UHFFFAOYSA-N furfural Chemical compound O=CC1=CC=CO1 HYBBIBNJHNGZAN-UHFFFAOYSA-N 0.000 description 2
108091006104 gene-regulatory proteins Proteins 0.000 description 2
230000001434 glomerular Effects 0.000 description 2
239000008103 glucose Substances 0.000 description 2
229940049906 glutamate Drugs 0.000 description 2
229930195712 glutamate Natural products 0.000 description 2
229960002989 glutamic acid Drugs 0.000 description 2
238000011194 good manufacturing practice Methods 0.000 description 2
230000035876 healing Effects 0.000 description 2
230000002440 hepatic effect Effects 0.000 description 2
125000004435 hydrogen atom Chemical group [H]* 0.000 description 2
FDGQSTZJBFJUBT-UHFFFAOYSA-N hypoxanthine Chemical compound O=C1NC=NC2=C1NC=N2 FDGQSTZJBFJUBT-UHFFFAOYSA-N 0.000 description 2
230000007954 hypoxia Effects 0.000 description 2
238000003384 imaging method Methods 0.000 description 2
239000012729 immediate-release (IR) formulation Substances 0.000 description 2
102000018358 immunoglobulin Human genes 0.000 description 2
238000003364 immunohistochemistry Methods 0.000 description 2
239000007943 implant Substances 0.000 description 2
238000001764 infiltration Methods 0.000 description 2
230000008595 infiltration Effects 0.000 description 2
238000001802 infusion Methods 0.000 description 2
239000003112 inhibitor Substances 0.000 description 2
NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 description 2
102000006495 integrins Human genes 0.000 description 2
108010044426 integrins Proteins 0.000 description 2
230000003993 interaction Effects 0.000 description 2
229940100601 interleukin-6 Drugs 0.000 description 2
210000000936 intestine Anatomy 0.000 description 2
230000037427 ion transport Effects 0.000 description 2
230000029795 kidney development Effects 0.000 description 2
239000002523 lectin Substances 0.000 description 2
229960003136 leucine Drugs 0.000 description 2
150000002632 lipids Chemical class 0.000 description 2
AGBQKNBQESQNJD-UHFFFAOYSA-M lipoate Chemical compound [O-]C(=O)CCCCC1CCSS1 AGBQKNBQESQNJD-UHFFFAOYSA-M 0.000 description 2
235000019136 lipoic acid Nutrition 0.000 description 2
231100000053 low toxicity Toxicity 0.000 description 2
238000012423 maintenance Methods 0.000 description 2
230000010874 maintenance of protein location Effects 0.000 description 2
VZCYOOQTPOCHFL-UPHRSURJSA-N maleic acid Chemical compound OC(=O)\C=C/C(O)=O VZCYOOQTPOCHFL-UPHRSURJSA-N 0.000 description 2
108020004999 messenger RNA Proteins 0.000 description 2
230000003278 mimic effect Effects 0.000 description 2
230000002988 nephrogenic effect Effects 0.000 description 2
229910052757 nitrogen Inorganic materials 0.000 description 2
230000007959 normoxia Effects 0.000 description 2
235000020824 obesity Nutrition 0.000 description 2
210000004738 parenchymal cell Anatomy 0.000 description 2
230000037361 pathway Effects 0.000 description 2
239000013610 patient sample Substances 0.000 description 2
229920000747 poly(lactic acid) Polymers 0.000 description 2
229920000058 polyacrylate Polymers 0.000 description 2
229920000728 polyester Polymers 0.000 description 2
238000003752 polymerase chain reaction Methods 0.000 description 2
235000013824 polyphenols Nutrition 0.000 description 2
229920001451 polypropylene glycol Polymers 0.000 description 2
229920002223 polystyrene Polymers 0.000 description 2
239000005077 polysulfide Substances 0.000 description 2
229920001021 polysulfide Polymers 0.000 description 2
150000008117 polysulfides Polymers 0.000 description 2
230000002035 prolonged effect Effects 0.000 description 2
201000001474 proteinuria Diseases 0.000 description 2
238000012797 qualification Methods 0.000 description 2
108700042226 ras Genes Proteins 0.000 description 2
230000001105 regulatory effect Effects 0.000 description 2
230000013878 renal filtration Effects 0.000 description 2
YGSDEFSMJLZEOE-UHFFFAOYSA-N salicylic acid Chemical compound OC(=O)C1=CC=CC=C1O YGSDEFSMJLZEOE-UHFFFAOYSA-N 0.000 description 2
150000003839 salts Chemical class 0.000 description 2
230000003248 secreting effect Effects 0.000 description 2
150000003384 small molecules Chemical class 0.000 description 2
210000002460 smooth muscle Anatomy 0.000 description 2
DAEPDZWVDSPTHF-UHFFFAOYSA-M sodium pyruvate Chemical compound [Na+].CC(=O)C([O-])=O DAEPDZWVDSPTHF-UHFFFAOYSA-M 0.000 description 2
239000011343 solid material Substances 0.000 description 2
239000002904 solvent Substances 0.000 description 2
241000894007 species Species 0.000 description 2
KZNICNPSHKQLFF-UHFFFAOYSA-N succinimide Chemical compound O=C1CCC(=O)N1 KZNICNPSHKQLFF-UHFFFAOYSA-N 0.000 description 2
230000008093 supporting effect Effects 0.000 description 2
230000002459 sustained effect Effects 0.000 description 2
208000024891 symptom Diseases 0.000 description 2
238000003786 synthesis reaction Methods 0.000 description 2
TXEYQDLBPFQVAA-UHFFFAOYSA-N tetrafluoromethane Chemical compound FC(F)(F)F TXEYQDLBPFQVAA-UHFFFAOYSA-N 0.000 description 2
229960002663 thioctic acid Drugs 0.000 description 2
229960000187 tissue plasminogen activator Drugs 0.000 description 2
VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 2
238000012546 transfer Methods 0.000 description 2
239000012581 transferrin Substances 0.000 description 2
230000001052 transient effect Effects 0.000 description 2
UFTFJSFQGQCHQW-UHFFFAOYSA-N triformin Chemical compound O=COCC(OC=O)COC=O UFTFJSFQGQCHQW-UHFFFAOYSA-N 0.000 description 2
239000012588 trypsin Substances 0.000 description 2
230000010024 tubular injury Effects 0.000 description 2
208000037978 tubular injury Diseases 0.000 description 2
238000002604 ultrasonography Methods 0.000 description 2
230000000007 visual effect Effects 0.000 description 2
235000005282 vitamin D3 Nutrition 0.000 description 2
239000011647 vitamin D3 Substances 0.000 description 2
QYSXJUFSXHHAJI-YRZJJWOYSA-N vitamin D3 Chemical compound C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C\C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-YRZJJWOYSA-N 0.000 description 2
229940021056 vitamin d3 Drugs 0.000 description 2
DGVVWUTYPXICAM-UHFFFAOYSA-N β‐Mercaptoethanol Chemical compound OCCS DGVVWUTYPXICAM-UHFFFAOYSA-N 0.000 description 2
PFTAWBLQPZVEMU-DZGCQCFKSA-N (+)-catechin Chemical compound C1([C@H]2OC3=CC(O)=CC(O)=C3C[C@@H]2O)=CC=C(O)C(O)=C1 PFTAWBLQPZVEMU-DZGCQCFKSA-N 0.000 description 1
FXYPGCIGRDZWNR-UHFFFAOYSA-N (2,5-dioxopyrrolidin-1-yl) 3-[[3-(2,5-dioxopyrrolidin-1-yl)oxy-3-oxopropyl]disulfanyl]propanoate Chemical compound O=C1CCC(=O)N1OC(=O)CCSSCCC(=O)ON1C(=O)CCC1=O FXYPGCIGRDZWNR-UHFFFAOYSA-N 0.000 description 1
KSEBMYQBYZTDHS-HWKANZROSA-M (E)-Ferulic acid Natural products COC1=CC(\C=C\C([O-])=O)=CC=C1O KSEBMYQBYZTDHS-HWKANZROSA-M 0.000 description 1
VLTXBOGHSBHSAC-UHFFFAOYSA-N 1,1,2,2,3,3,4,4,5,5,6-undecafluoro-6-[1,1,1,3,3,3-hexafluoro-2-(trifluoromethyl)propan-2-yl]cyclohexane Chemical compound FC(F)(F)C(C(F)(F)F)(C(F)(F)F)C1(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C1(F)F VLTXBOGHSBHSAC-UHFFFAOYSA-N 0.000 description 1
UWFRVQVNYNPBEF-UHFFFAOYSA-N 1-(2,4-dimethylphenyl)propan-1-one Chemical compound CCC(=O)C1=CC=C(C)C=C1C UWFRVQVNYNPBEF-UHFFFAOYSA-N 0.000 description 1
FPIPGXGPPPQFEQ-UHFFFAOYSA-N 13-cis retinol Natural products OCC=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-UHFFFAOYSA-N 0.000 description 1
NHJVRSWLHSJWIN-UHFFFAOYSA-N 2,4,6-trinitrobenzenesulfonic acid Chemical compound OS(=O)(=O)C1=C([N+]([O-])=O)C=C([N+]([O-])=O)C=C1[N+]([O-])=O NHJVRSWLHSJWIN-UHFFFAOYSA-N 0.000 description 1
SYEKJCKNTHYWOJ-UHFFFAOYSA-N 2-(2,5-dioxopyrrolidin-1-yl)-2-sulfobutanedioic acid;ethane-1,2-diol Chemical compound OCCO.OC(=O)CC(S(O)(=O)=O)(C(O)=O)N1C(=O)CCC1=O.OC(=O)CC(S(O)(=O)=O)(C(O)=O)N1C(=O)CCC1=O SYEKJCKNTHYWOJ-UHFFFAOYSA-N 0.000 description 1
JKMHFZQWWAIEOD-UHFFFAOYSA-N 2-[4-(2-hydroxyethyl)piperazin-1-yl]ethanesulfonic acid Chemical compound OCC[NH+]1CCN(CCS([O-])(=O)=O)CC1 JKMHFZQWWAIEOD-UHFFFAOYSA-N 0.000 description 1
SHKUUQIDMUMQQK-UHFFFAOYSA-N 2-[4-(oxiran-2-ylmethoxy)butoxymethyl]oxirane Chemical class C1OC1COCCCCOCC1CO1 SHKUUQIDMUMQQK-UHFFFAOYSA-N 0.000 description 1
WSSSPWUEQFSQQG-UHFFFAOYSA-N 4-methyl-1-pentene Chemical compound CC(C)CC=C WSSSPWUEQFSQQG-UHFFFAOYSA-N 0.000 description 1
KPBRHHQUJSXYSU-UHFFFAOYSA-N 5-(2,5-dioxo-3-sulfopyrrolidin-1-yl)oxy-5-oxopentanoic acid Chemical compound OC(CCCC(ON(C(CC1S(O)(=O)=O)=O)C1=O)=O)=O KPBRHHQUJSXYSU-UHFFFAOYSA-N 0.000 description 1
101150044182 8 gene Proteins 0.000 description 1
101150043214 AGXT2 gene Proteins 0.000 description 1
101150040698 ANGPT2 gene Proteins 0.000 description 1
101150058497 ANPEP gene Proteins 0.000 description 1
101150027946 Acsm2 gene Proteins 0.000 description 1
101710167788 Acyl-coenzyme A synthetase ACSM2, mitochondrial Proteins 0.000 description 1
101710092790 Acyl-coenzyme A synthetase ACSM2A, mitochondrial Proteins 0.000 description 1
102100030362 Acyl-coenzyme A synthetase ACSM2B, mitochondrial Human genes 0.000 description 1
102000011690 Adiponectin Human genes 0.000 description 1
108010076365 Adiponectin Proteins 0.000 description 1
229920000936 Agarose Polymers 0.000 description 1
HJCMDXDYPOUFDY-WHFBIAKZSA-N Ala-Gln Chemical compound C[C@H](N)C(=O)N[C@H](C(O)=O)CCC(N)=O HJCMDXDYPOUFDY-WHFBIAKZSA-N 0.000 description 1
102100026790 Alanine-glyoxylate aminotransferase 2, mitochondrial Human genes 0.000 description 1
108010033918 Alanine-glyoxylate transaminase Proteins 0.000 description 1
102000052030 Aldehyde Dehydrogenase 1 Family Human genes 0.000 description 1
108700041701 Aldehyde Dehydrogenase 1 Family Proteins 0.000 description 1
102100039075 Aldehyde dehydrogenase family 1 member A3 Human genes 0.000 description 1
102000003966 Alpha-1-microglobulin Human genes 0.000 description 1
101800001761 Alpha-1-microglobulin Proteins 0.000 description 1
102100022749 Aminopeptidase N Human genes 0.000 description 1
101150073415 Aqp4 gene Proteins 0.000 description 1
101150005351 Aqp7 gene Proteins 0.000 description 1
108050006915 Aquaporin 7 Proteins 0.000 description 1
102100029406 Aquaporin-7 Human genes 0.000 description 1
JEBFVOLFMLUKLF-IFPLVEIFSA-N Astaxanthin Natural products CC(=C/C=C/C(=C/C=C/C1=C(C)C(=O)C(O)CC1(C)C)/C)C=CC=C(/C)C=CC=C(/C)C=CC2=C(C)C(=O)C(O)CC2(C)C JEBFVOLFMLUKLF-IFPLVEIFSA-N 0.000 description 1
208000023275 Autoimmune disease Diseases 0.000 description 1
HRQKOYFGHJYEFS-UHFFFAOYSA-N Beta psi-carotene Chemical compound CC(C)=CCCC(C)=CC=CC(C)=CC=CC(C)=CC=CC=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C HRQKOYFGHJYEFS-UHFFFAOYSA-N 0.000 description 1
DWRXFEITVBNRMK-UHFFFAOYSA-N Beta-D-1-Arabinofuranosylthymine Natural products O=C1NC(=O)C(C)=CN1C1C(O)C(O)C(CO)O1 DWRXFEITVBNRMK-UHFFFAOYSA-N 0.000 description 1
102000015735 Beta-catenin Human genes 0.000 description 1
108060000903 Beta-catenin Proteins 0.000 description 1
102100032367 C-C motif chemokine 5 Human genes 0.000 description 1
101150098097 CLTRN gene Proteins 0.000 description 1
102100024151 Cadherin-16 Human genes 0.000 description 1
101710196874 Cadherin-16 Proteins 0.000 description 1
102100029761 Cadherin-5 Human genes 0.000 description 1
102000014273 Calpain-8 Human genes 0.000 description 1
108050003158 Calpain-8 Proteins 0.000 description 1
BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate Chemical compound [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 description 1
229920002134 Carboxymethyl cellulose Polymers 0.000 description 1
241001012508 Carpiodes cyprinus Species 0.000 description 1
102000014914 Carrier Proteins Human genes 0.000 description 1
108010055166 Chemokine CCL5 Proteins 0.000 description 1
102000009410 Chemokine receptor Human genes 0.000 description 1
108050000299 Chemokine receptor Proteins 0.000 description 1
108010012236 Chemokines Proteins 0.000 description 1
102000019034 Chemokines Human genes 0.000 description 1
102100038445 Claudin-2 Human genes 0.000 description 1
108090000580 Claudin-2 Proteins 0.000 description 1
102000012422 Collagen Type I Human genes 0.000 description 1
108010022452 Collagen Type I Proteins 0.000 description 1
102000012432 Collagen Type V Human genes 0.000 description 1
108010022514 Collagen Type V Proteins 0.000 description 1
102000029816 Collagenase Human genes 0.000 description 1
108060005980 Collagenase Proteins 0.000 description 1
102100033635 Collectrin Human genes 0.000 description 1
101710138990 Collectrin Proteins 0.000 description 1
108010039419 Connective Tissue Growth Factor Proteins 0.000 description 1
102000015225 Connective Tissue Growth Factor Human genes 0.000 description 1
241000195493 Cryptophyta Species 0.000 description 1
102000012192 Cystatin C Human genes 0.000 description 1
108010061642 Cystatin C Proteins 0.000 description 1
MNQZXJOMYWMBOU-VKHMYHEASA-N D-glyceraldehyde Chemical compound OC[C@@H](O)C=O MNQZXJOMYWMBOU-VKHMYHEASA-N 0.000 description 1
108020004414 DNA Proteins 0.000 description 1
108020005199 Dehydrogenases Proteins 0.000 description 1
101150001833 EDNRB gene Proteins 0.000 description 1
238000002965 ELISA Methods 0.000 description 1
239000006145 Eagle's minimal essential medium Substances 0.000 description 1
102000016942 Elastin Human genes 0.000 description 1
108010014258 Elastin Proteins 0.000 description 1
102100040611 Endothelin receptor type B Human genes 0.000 description 1
101710194572 Endothelin receptor type B Proteins 0.000 description 1
241000283086 Equidae Species 0.000 description 1
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 1
108050001049 Extracellular proteins Proteins 0.000 description 1
101150010122 FBP1 gene Proteins 0.000 description 1
101150019487 FXYD2 gene Proteins 0.000 description 1
241000282326 Felis catus Species 0.000 description 1
102000009842 Fibril-Associated Collagens Human genes 0.000 description 1
108010020305 Fibril-Associated Collagens Proteins 0.000 description 1
108010080379 Fibrin Tissue Adhesive Proteins 0.000 description 1
102000003972 Fibroblast growth factor 7 Human genes 0.000 description 1
108090000385 Fibroblast growth factor 7 Proteins 0.000 description 1
102100037181 Fructose-1,6-bisphosphatase 1 Human genes 0.000 description 1
101710179254 Fructose-1,6-bisphosphatase 1 Proteins 0.000 description 1
101150098511 GPX3 gene Proteins 0.000 description 1
229920002148 Gellan gum Polymers 0.000 description 1
AZKVWQKMDGGDSV-BCMRRPTOSA-N Genipin Chemical compound COC(=O)C1=CO[C@@H](O)[C@@H]2C(CO)=CC[C@H]12 AZKVWQKMDGGDSV-BCMRRPTOSA-N 0.000 description 1
102000042092 Glucose transporter family Human genes 0.000 description 1
108091052347 Glucose transporter family Proteins 0.000 description 1
102000009127 Glutaminase Human genes 0.000 description 1
108010073324 Glutaminase Proteins 0.000 description 1
SXRSQZLOMIGNAQ-UHFFFAOYSA-N Glutaraldehyde Chemical compound O=CCCCC=O SXRSQZLOMIGNAQ-UHFFFAOYSA-N 0.000 description 1
102100033053 Glutathione peroxidase 3 Human genes 0.000 description 1
101710119049 Glutathione peroxidase 3 Proteins 0.000 description 1
239000007995 HEPES buffer Substances 0.000 description 1
206010019280 Heart failures Diseases 0.000 description 1
102000001554 Hemoglobins Human genes 0.000 description 1
108010054147 Hemoglobins Proteins 0.000 description 1
208000027761 Hepatic autoimmune disease Diseases 0.000 description 1
241000282412 Homo Species 0.000 description 1
101000959046 Homo sapiens Aldehyde dehydrogenase family 1 member A3 Proteins 0.000 description 1
101000757160 Homo sapiens Aminopeptidase N Proteins 0.000 description 1
101000975502 Homo sapiens Keratin, type II cytoskeletal 7 Proteins 0.000 description 1
101000975496 Homo sapiens Keratin, type II cytoskeletal 8 Proteins 0.000 description 1
101000645293 Homo sapiens Metalloproteinase inhibitor 3 Proteins 0.000 description 1
101001052493 Homo sapiens Mitogen-activated protein kinase 1 Proteins 0.000 description 1
101001052490 Homo sapiens Mitogen-activated protein kinase 3 Proteins 0.000 description 1
101000581940 Homo sapiens Napsin-A Proteins 0.000 description 1
102000001974 Hyaluronidases Human genes 0.000 description 1
108050009363 Hyaluronidases Proteins 0.000 description 1
VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 1
206010020880 Hypertrophy Diseases 0.000 description 1
UGQMRVRMYYASKQ-UHFFFAOYSA-N Hypoxanthine nucleoside Natural products OC1C(O)C(CO)OC1N1C(NC=NC2=O)=C2N=C1 UGQMRVRMYYASKQ-UHFFFAOYSA-N 0.000 description 1
102000018118 ICln Human genes 0.000 description 1
108050007228 ICln Proteins 0.000 description 1
IVYPNXXAYMYVSP-UHFFFAOYSA-N Indole-3-carbinol Natural products C1=CC=C2C(CO)=CNC2=C1 IVYPNXXAYMYVSP-UHFFFAOYSA-N 0.000 description 1
IMQLKJBTEOYOSI-GPIVLXJGSA-N Inositol-hexakisphosphate Chemical compound OP(O)(=O)O[C@H]1[C@H](OP(O)(O)=O)[C@@H](OP(O)(O)=O)[C@H](OP(O)(O)=O)[C@H](OP(O)(O)=O)[C@@H]1OP(O)(O)=O IMQLKJBTEOYOSI-GPIVLXJGSA-N 0.000 description 1
108090001061 Insulin Proteins 0.000 description 1
102100023915 Insulin Human genes 0.000 description 1
102000015696 Interleukins Human genes 0.000 description 1
108010063738 Interleukins Proteins 0.000 description 1
102000012411 Intermediate Filament Proteins Human genes 0.000 description 1
108010061998 Intermediate Filament Proteins Proteins 0.000 description 1
208000008839 Kidney Neoplasms Diseases 0.000 description 1
241000235058 Komagataella pastoris Species 0.000 description 1
229930182816 L-glutamine Natural products 0.000 description 1
125000003338 L-glutaminyl group Chemical group O=C([*])[C@](N([H])[H])([H])C([H])([H])C([H])([H])C(=O)N([H])[H] 0.000 description 1
MVVPAYGKZXZGRC-HNNXBMFYSA-N L-leucine 4-methoxy-2-naphthylamide Chemical compound C1=CC=C2C(OC)=CC(NC(=O)[C@@H](N)CC(C)C)=CC2=C1 MVVPAYGKZXZGRC-HNNXBMFYSA-N 0.000 description 1
102000018697 Membrane Proteins Human genes 0.000 description 1
102100026261 Metalloproteinase inhibitor 3 Human genes 0.000 description 1
108700011259 MicroRNAs Proteins 0.000 description 1
102100024193 Mitogen-activated protein kinase 1 Human genes 0.000 description 1
102100024192 Mitogen-activated protein kinase 3 Human genes 0.000 description 1
241000713333 Mouse mammary tumor virus Species 0.000 description 1
101100503236 Mus musculus Folr1 gene Proteins 0.000 description 1
101100347983 Mus musculus Napsa gene Proteins 0.000 description 1
108010057466 NF-kappa B Proteins 0.000 description 1
102000003945 NF-kappa B Human genes 0.000 description 1
102100027343 Napsin-A Human genes 0.000 description 1
102400000097 Neurokinin A Human genes 0.000 description 1
102100027341 Neutral and basic amino acid transport protein rBAT Human genes 0.000 description 1
101710159376 Neutral and basic amino acid transport protein rBAT Proteins 0.000 description 1
102100034457 Nodal homolog Human genes 0.000 description 1
101710144669 Nodal homolog Proteins 0.000 description 1
238000000636 Northern blotting Methods 0.000 description 1
ZCQWOFVYLHDMMC-UHFFFAOYSA-N Oxazole Chemical compound C1=COC=N1 ZCQWOFVYLHDMMC-UHFFFAOYSA-N 0.000 description 1
238000010222 PCR analysis Methods 0.000 description 1
239000002033 PVDF binder Substances 0.000 description 1
101001042436 Patiria pectinifera Alpha-N-acetylgalactosamine-specific lectin Proteins 0.000 description 1
241001494479 Pecora Species 0.000 description 1
108090000279 Peptidyltransferases Proteins 0.000 description 1
BELBBZDIHDAJOR-UHFFFAOYSA-N Phenolsulfonephthalein Chemical compound C1=CC(O)=CC=C1C1(C=2C=CC(O)=CC=2)C2=CC=CC=C2S(=O)(=O)O1 BELBBZDIHDAJOR-UHFFFAOYSA-N 0.000 description 1
108091000080 Phosphotransferase Proteins 0.000 description 1
IMQLKJBTEOYOSI-UHFFFAOYSA-N Phytic acid Natural products OP(O)(=O)OC1C(OP(O)(O)=O)C(OP(O)(O)=O)C(OP(O)(O)=O)C(OP(O)(O)=O)C1OP(O)(O)=O IMQLKJBTEOYOSI-UHFFFAOYSA-N 0.000 description 1
108010038512 Platelet-Derived Growth Factor Proteins 0.000 description 1
102000010780 Platelet-Derived Growth Factor Human genes 0.000 description 1
239000004696 Poly ether ether ketone Substances 0.000 description 1
239000004952 Polyamide Substances 0.000 description 1
239000004962 Polyamide-imide Substances 0.000 description 1
229920002732 Polyanhydride Polymers 0.000 description 1
239000004695 Polyether sulfone Substances 0.000 description 1
239000004697 Polyetherimide Substances 0.000 description 1
239000002202 Polyethylene glycol Substances 0.000 description 1
229920000954 Polyglycolide Polymers 0.000 description 1
239000004642 Polyimide Substances 0.000 description 1
229920001710 Polyorthoester Polymers 0.000 description 1
239000004721 Polyphenylene oxide Substances 0.000 description 1
239000004734 Polyphenylene sulfide Substances 0.000 description 1
239000004743 Polypropylene Substances 0.000 description 1
239000004372 Polyvinyl alcohol Substances 0.000 description 1
ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 1
108010050808 Procollagen Proteins 0.000 description 1
102000016611 Proteoglycans Human genes 0.000 description 1
108010067787 Proteoglycans Proteins 0.000 description 1
ZVOLCUVKHLEPEV-UHFFFAOYSA-N Quercetagetin Natural products C1=C(O)C(O)=CC=C1C1=C(O)C(=O)C2=C(O)C(O)=C(O)C=C2O1 ZVOLCUVKHLEPEV-UHFFFAOYSA-N 0.000 description 1
238000003559 RNA-seq method Methods 0.000 description 1
101100247004 Rattus norvegicus Qsox1 gene Proteins 0.000 description 1
102100037420 Regulator of G-protein signaling 4 Human genes 0.000 description 1
101710140404 Regulator of G-protein signaling 4 Proteins 0.000 description 1
208000006265 Renal cell carcinoma Diseases 0.000 description 1
206010038486 Renal neoplasms Diseases 0.000 description 1
PLXBWHJQWKZRKG-UHFFFAOYSA-N Resazurin Chemical compound C1=CC(=O)C=C2OC3=CC(O)=CC=C3[N+]([O-])=C21 PLXBWHJQWKZRKG-UHFFFAOYSA-N 0.000 description 1
QNVSXXGDAPORNA-UHFFFAOYSA-N Resveratrol Natural products OC1=CC=CC(C=CC=2C=C(O)C(O)=CC=2)=C1 QNVSXXGDAPORNA-UHFFFAOYSA-N 0.000 description 1
108010081750 Reticulin Proteins 0.000 description 1
101150061614 Rgs4 gene Proteins 0.000 description 1
HWTZYBCRDDUBJY-UHFFFAOYSA-N Rhynchosin Natural products C1=C(O)C(O)=CC=C1C1=C(O)C(=O)C2=CC(O)=C(O)C=C2O1 HWTZYBCRDDUBJY-UHFFFAOYSA-N 0.000 description 1
241000283984 Rodentia Species 0.000 description 1
101150091821 SLC3A1 gene Proteins 0.000 description 1
240000004808 Saccharomyces cerevisiae Species 0.000 description 1
101000605416 Scyliorhinus canicula Phospholemman-like protein Proteins 0.000 description 1
BUGBHKTXTAQXES-UHFFFAOYSA-N Selenium Chemical compound [Se] BUGBHKTXTAQXES-UHFFFAOYSA-N 0.000 description 1
101150116689 Slc2a2 gene Proteins 0.000 description 1
UIIMBOGNXHQVGW-DEQYMQKBSA-M Sodium bicarbonate-14C Chemical compound [Na+].O[14C]([O-])=O UIIMBOGNXHQVGW-DEQYMQKBSA-M 0.000 description 1
238000002105 Southern blotting Methods 0.000 description 1
101150112740 Srgn gene Proteins 0.000 description 1
101710172711 Structural protein Proteins 0.000 description 1
229930006000 Sucrose Natural products 0.000 description 1
CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 1
241000282887 Suidae Species 0.000 description 1
102000019197 Superoxide Dismutase Human genes 0.000 description 1
108010012715 Superoxide dismutase Proteins 0.000 description 1
229920002359 Tetronic® Polymers 0.000 description 1
241000746181 Therates Species 0.000 description 1
101150079992 Timp3 gene Proteins 0.000 description 1
102000005406 Tissue Inhibitor of Metalloproteinase-3 Human genes 0.000 description 1
LUKBXSAWLPMMSZ-OWOJBTEDSA-N Trans-resveratrol Chemical compound C1=CC(O)=CC=C1\C=C\C1=CC(O)=CC(O)=C1 LUKBXSAWLPMMSZ-OWOJBTEDSA-N 0.000 description 1
108091023040 Transcription factor Proteins 0.000 description 1
102000040945 Transcription factor Human genes 0.000 description 1
102100024270 Transcription factor SOX-2 Human genes 0.000 description 1
108050000630 Transcription factor SOX-2 Proteins 0.000 description 1
102000046299 Transforming Growth Factor beta1 Human genes 0.000 description 1
101800002279 Transforming growth factor beta-1 Proteins 0.000 description 1
108060008539 Transglutaminase Proteins 0.000 description 1
102100023935 Transmembrane glycoprotein NMB Human genes 0.000 description 1
GLEVLJDDWXEYCO-UHFFFAOYSA-N Trolox Chemical compound O1C(C)(C(O)=O)CCC2=C1C(C)=C(C)C(O)=C2C GLEVLJDDWXEYCO-UHFFFAOYSA-N 0.000 description 1
102100031988 Tumor necrosis factor ligand superfamily member 6 Human genes 0.000 description 1
108050002568 Tumor necrosis factor ligand superfamily member 6 Proteins 0.000 description 1
229920001807 Urea-formaldehyde Polymers 0.000 description 1
FPIPGXGPPPQFEQ-BOOMUCAASA-N Vitamin A Natural products OC/C=C(/C)\C=C\C=C(\C)/C=C/C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-BOOMUCAASA-N 0.000 description 1
229930003316 Vitamin D Natural products 0.000 description 1
206010047626 Vitamin D Deficiency Diseases 0.000 description 1
229930003427 Vitamin E Natural products 0.000 description 1
101150010310 WNT-4 gene Proteins 0.000 description 1
208000008383 Wilms tumor Diseases 0.000 description 1
208000026448 Wilms tumor 1 Diseases 0.000 description 1
102100022748 Wilms tumor protein Human genes 0.000 description 1
101710127857 Wilms tumor protein Proteins 0.000 description 1
102000052548 Wnt-4 Human genes 0.000 description 1
108700020984 Wnt-4 Proteins 0.000 description 1
DYTKVFHLKPDNRW-UHFFFAOYSA-N [4-(2-amino-4-methyl-thiazol-5-yl)-pyrimidin-2-yl]-(3-nitro-phenyl)-amine Chemical compound N1=C(N)SC(C=2N=C(NC=3C=C(C=CC=3)[N+]([O-])=O)N=CC=2)=C1C DYTKVFHLKPDNRW-UHFFFAOYSA-N 0.000 description 1
238000009825 accumulation Methods 0.000 description 1
230000002378 acidificating effect Effects 0.000 description 1
230000004913 activation Effects 0.000 description 1
230000009692 acute damage Effects 0.000 description 1
230000001154 acute effect Effects 0.000 description 1
210000000577 adipose tissue Anatomy 0.000 description 1
150000001299 aldehydes Chemical class 0.000 description 1
150000001323 aldoses Chemical class 0.000 description 1
OENHQHLEOONYIE-UKMVMLAPSA-N all-trans beta-carotene Natural products CC=1CCCC(C)(C)C=1/C=C/C(/C)=C/C=C/C(/C)=C/C=C/C=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C OENHQHLEOONYIE-UKMVMLAPSA-N 0.000 description 1
FPIPGXGPPPQFEQ-OVSJKPMPSA-N all-trans-retinol Chemical compound OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-OVSJKPMPSA-N 0.000 description 1
239000011795 alpha-carotene Substances 0.000 description 1
235000003903 alpha-carotene Nutrition 0.000 description 1
ANVAOWXLWRTKGA-HLLMEWEMSA-N alpha-carotene Natural products C(=C\C=C\C=C(/C=C/C=C(\C=C\C=1C(C)(C)CCCC=1C)/C)\C)(\C=C\C=C(/C=C/[C@H]1C(C)=CCCC1(C)C)\C)/C ANVAOWXLWRTKGA-HLLMEWEMSA-N 0.000 description 1
230000003321 amplification Effects 0.000 description 1
239000003708 ampul Substances 0.000 description 1
230000000202 analgesic effect Effects 0.000 description 1
230000019552 anatomical structure morphogenesis Effects 0.000 description 1
230000002491 angiogenic effect Effects 0.000 description 1
210000004102 animal cell Anatomy 0.000 description 1
230000003110 anti-inflammatory effect Effects 0.000 description 1
230000000259 anti-tumor effect Effects 0.000 description 1
230000000840 anti-viral effect Effects 0.000 description 1
230000001640 apoptogenic effect Effects 0.000 description 1
230000006907 apoptotic process Effects 0.000 description 1
239000012062 aqueous buffer Substances 0.000 description 1
239000007864 aqueous solution Substances 0.000 description 1
229960005070 ascorbic acid Drugs 0.000 description 1
235000010323 ascorbic acid Nutrition 0.000 description 1
239000011668 ascorbic acid Substances 0.000 description 1
235000013793 astaxanthin Nutrition 0.000 description 1
239000001168 astaxanthin Substances 0.000 description 1
MQZIGYBFDRPAKN-ZWAPEEGVSA-N astaxanthin Chemical compound C([C@H](O)C(=O)C=1C)C(C)(C)C=1/C=C/C(/C)=C/C=C/C(/C)=C/C=C/C=C(C)C=CC=C(C)C=CC1=C(C)C(=O)[C@@H](O)CC1(C)C MQZIGYBFDRPAKN-ZWAPEEGVSA-N 0.000 description 1
229940022405 astaxanthin Drugs 0.000 description 1
230000003416 augmentation Effects 0.000 description 1
102000015736 beta 2-Microglobulin Human genes 0.000 description 1
108010081355 beta 2-Microglobulin Proteins 0.000 description 1
IQFYYKKMVGJFEH-UHFFFAOYSA-N beta-L-thymidine Natural products O=C1NC(=O)C(C)=CN1C1OC(CO)C(O)C1 IQFYYKKMVGJFEH-UHFFFAOYSA-N 0.000 description 1
235000013734 beta-carotene Nutrition 0.000 description 1
239000011648 beta-carotene Substances 0.000 description 1
TUPZEYHYWIEDIH-WAIFQNFQSA-N beta-carotene Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C1=C(C)CCCC1(C)C)C=CC=C(/C)C=CC2=CCCCC2(C)C TUPZEYHYWIEDIH-WAIFQNFQSA-N 0.000 description 1
229960002747 betacarotene Drugs 0.000 description 1
108091008324 binding proteins Proteins 0.000 description 1
229920000249 biocompatible polymer Polymers 0.000 description 1
230000033558 biomineral tissue development Effects 0.000 description 1
210000000481 breast Anatomy 0.000 description 1
239000007975 buffered saline Substances 0.000 description 1
DQXBYHZEEUGOBF-UHFFFAOYSA-N but-3-enoic acid;ethene Chemical compound C=C.OC(=O)CC=C DQXBYHZEEUGOBF-UHFFFAOYSA-N 0.000 description 1
239000006227 byproduct Substances 0.000 description 1
238000010805 cDNA synthesis kit Methods 0.000 description 1
108010018828 cadherin 5 Proteins 0.000 description 1
238000011088 calibration curve Methods 0.000 description 1
PFKFTWBEEFSNDU-UHFFFAOYSA-N carbonyldiimidazole Chemical compound C1=CN=CN1C(=O)N1C=CN=C1 PFKFTWBEEFSNDU-UHFFFAOYSA-N 0.000 description 1
239000001768 carboxy methyl cellulose Substances 0.000 description 1
235000010948 carboxy methyl cellulose Nutrition 0.000 description 1
239000008112 carboxymethyl-cellulose Substances 0.000 description 1
239000000679 carrageenan Substances 0.000 description 1
235000010418 carrageenan Nutrition 0.000 description 1
229920001525 carrageenan Polymers 0.000 description 1
229940113118 carrageenan Drugs 0.000 description 1
235000005487 catechin Nutrition 0.000 description 1
ADRVNXBAWSRFAJ-UHFFFAOYSA-N catechin Natural products OC1Cc2cc(O)cc(O)c2OC1c3ccc(O)c(O)c3 ADRVNXBAWSRFAJ-UHFFFAOYSA-N 0.000 description 1
150000001768 cations Chemical class 0.000 description 1
230000020411 cell activation Effects 0.000 description 1
108010015046 cell aggregation factors Proteins 0.000 description 1
230000005779 cell damage Effects 0.000 description 1
230000024245 cell differentiation Effects 0.000 description 1
230000032823 cell division Effects 0.000 description 1
230000006727 cell loss Effects 0.000 description 1
230000012292 cell migration Effects 0.000 description 1
239000013553 cell monolayer Substances 0.000 description 1
239000012094 cell viability reagent Substances 0.000 description 1
230000033077 cellular process Effects 0.000 description 1
210000003850 cellular structure Anatomy 0.000 description 1
239000001913 cellulose Substances 0.000 description 1
229920003086 cellulose ether Polymers 0.000 description 1
KQJQGYQIHVYKTF-UHFFFAOYSA-N cerium(3+);trinitrate;hydrate Chemical compound O.[Ce+3].[O-][N+]([O-])=O.[O-][N+]([O-])=O.[O-][N+]([O-])=O KQJQGYQIHVYKTF-UHFFFAOYSA-N 0.000 description 1
230000001684 chronic effect Effects 0.000 description 1
229950001002 cianidanol Drugs 0.000 description 1
OVSVTCFNLSGAMM-KGBODLQUSA-N cis-phytofluene Natural products CC(=CCCC(=CCCC(=CCCC(=CC=C/C=C(C)/C=C/C=C(C)/CCC=C(/C)CCC=C(C)C)C)C)C)C OVSVTCFNLSGAMM-KGBODLQUSA-N 0.000 description 1
238000003776 cleavage reaction Methods 0.000 description 1
230000007012 clinical effect Effects 0.000 description 1
229940110767 coenzyme Q10 Drugs 0.000 description 1
229960005188 collagen Drugs 0.000 description 1
229940096422 collagen type i Drugs 0.000 description 1
229960002424 collagenase Drugs 0.000 description 1
238000005056 compaction Methods 0.000 description 1
230000000536 complexating effect Effects 0.000 description 1
239000012141 concentrate Substances 0.000 description 1
229920002770 condensed tannin Polymers 0.000 description 1
230000003750 conditioning effect Effects 0.000 description 1
238000011109 contamination Methods 0.000 description 1
239000002872 contrast media Substances 0.000 description 1
229920001577 copolymer Polymers 0.000 description 1
210000004087 cornea Anatomy 0.000 description 1
239000011557 critical solution Substances 0.000 description 1
230000002338 cryopreservative effect Effects 0.000 description 1
238000012136 culture method Methods 0.000 description 1
235000012754 curcumin Nutrition 0.000 description 1
239000004148 curcumin Substances 0.000 description 1
229940109262 curcumin Drugs 0.000 description 1
210000004292 cytoskeleton Anatomy 0.000 description 1
230000034994 death Effects 0.000 description 1
230000032459 dedifferentiation Effects 0.000 description 1
230000000593 degrading effect Effects 0.000 description 1
230000001934 delay Effects 0.000 description 1
210000003074 dental pulp Anatomy 0.000 description 1
210000004268 dentin Anatomy 0.000 description 1
230000014541 detection of hypoxia Effects 0.000 description 1
239000008121 dextrose Substances 0.000 description 1
230000035487 diastolic blood pressure Effects 0.000 description 1
VFLDPWHFBUODDF-UHFFFAOYSA-N diferuloylmethane Natural products C1=C(O)C(OC)=CC(C=CC(=O)CC(=O)C=CC=2C=C(OC)C(O)=CC=2)=C1 VFLDPWHFBUODDF-UHFFFAOYSA-N 0.000 description 1
238000009792 diffusion process Methods 0.000 description 1
208000010643 digestive system disease Diseases 0.000 description 1
238000010494 dissociation reaction Methods 0.000 description 1
230000005593 dissociations Effects 0.000 description 1
239000002552 dosage form Substances 0.000 description 1
238000012377 drug delivery Methods 0.000 description 1
238000009509 drug development Methods 0.000 description 1
210000001755 duct epithelial cell Anatomy 0.000 description 1
230000004064 dysfunction Effects 0.000 description 1
229920002549 elastin Polymers 0.000 description 1
239000003792 electrolyte Substances 0.000 description 1
230000008030 elimination Effects 0.000 description 1
238000003379 elimination reaction Methods 0.000 description 1
210000002308 embryonic cell Anatomy 0.000 description 1
238000005538 encapsulation Methods 0.000 description 1
201000000523 end stage renal failure Diseases 0.000 description 1
230000002121 endocytic effect Effects 0.000 description 1
210000003038 endothelium Anatomy 0.000 description 1
210000003989 endothelium vascular Anatomy 0.000 description 1
230000002708 enhancing effect Effects 0.000 description 1
230000007613 environmental effect Effects 0.000 description 1
150000002118 epoxides Chemical class 0.000 description 1
230000010437 erythropoiesis Effects 0.000 description 1
235000019441 ethanol Nutrition 0.000 description 1
239000005038 ethylene vinyl acetate Substances 0.000 description 1
230000029142 excretion Effects 0.000 description 1
238000013265 extended release Methods 0.000 description 1
230000016691 extracellular matrix constituent secretion Effects 0.000 description 1
210000001723 extracellular space Anatomy 0.000 description 1
238000000605 extraction Methods 0.000 description 1
KSEBMYQBYZTDHS-HWKANZROSA-N ferulic acid Chemical compound COC1=CC(\C=C\C(O)=O)=CC=C1O KSEBMYQBYZTDHS-HWKANZROSA-N 0.000 description 1
235000001785 ferulic acid Nutrition 0.000 description 1
229940114124 ferulic acid Drugs 0.000 description 1
KSEBMYQBYZTDHS-UHFFFAOYSA-N ferulic acid Natural products COC1=CC(C=CC(O)=O)=CC=C1O KSEBMYQBYZTDHS-UHFFFAOYSA-N 0.000 description 1
210000004700 fetal blood Anatomy 0.000 description 1
238000011049 filling Methods 0.000 description 1
239000013020 final formulation Substances 0.000 description 1
229930003935 flavonoid Natural products 0.000 description 1
235000017173 flavonoids Nutrition 0.000 description 1
150000002215 flavonoids Chemical class 0.000 description 1
238000002509 fluorescent in situ hybridization Methods 0.000 description 1
238000012395 formulation development Methods 0.000 description 1
238000007710 freezing Methods 0.000 description 1
230000008014 freezing Effects 0.000 description 1
239000012520 frozen sample Substances 0.000 description 1
238000011990 functional testing Methods 0.000 description 1
239000011663 gamma-carotene Substances 0.000 description 1
235000000633 gamma-carotene Nutrition 0.000 description 1
HRQKOYFGHJYEFS-RZWPOVEWSA-N gamma-carotene Natural products C(=C\C=C\C(=C/C=C/C=C(\C=C\C=C(/C=C/C=1C(C)(C)CCCC=1C)\C)/C)\C)(\C=C\C=C(/CC/C=C(\C)/C)\C)/C HRQKOYFGHJYEFS-RZWPOVEWSA-N 0.000 description 1
125000002642 gamma-glutamyl group Chemical group 0.000 description 1
WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 description 1
210000001035 gastrointestinal tract Anatomy 0.000 description 1
238000001502 gel electrophoresis Methods 0.000 description 1
239000000216 gellan gum Substances 0.000 description 1
235000010492 gellan gum Nutrition 0.000 description 1
AZKVWQKMDGGDSV-UHFFFAOYSA-N genipin Natural products COC(=O)C1=COC(O)C2C(CO)=CCC12 AZKVWQKMDGGDSV-UHFFFAOYSA-N 0.000 description 1
239000011521 glass Substances 0.000 description 1
ZDXPYRJPNDTMRX-UHFFFAOYSA-N glutamine Natural products OC(=O)C(N)CCC(N)=O ZDXPYRJPNDTMRX-UHFFFAOYSA-N 0.000 description 1
229960002743 glutamine Drugs 0.000 description 1
230000002641 glycemic effect Effects 0.000 description 1
201000011205 glycine encephalopathy Diseases 0.000 description 1
230000003394 haemopoietic effect Effects 0.000 description 1
238000003306 harvesting Methods 0.000 description 1
230000003862 health status Effects 0.000 description 1
238000005534 hematocrit Methods 0.000 description 1
108010037896 heparin-binding hemagglutinin Proteins 0.000 description 1
230000001744 histochemical effect Effects 0.000 description 1
230000003301 hydrolyzing effect Effects 0.000 description 1
229920001477 hydrophilic polymer Polymers 0.000 description 1
150000002466 imines Chemical class 0.000 description 1
210000002865 immune cell Anatomy 0.000 description 1
230000001900 immune effect Effects 0.000 description 1
230000003832 immune regulation Effects 0.000 description 1
238000003119 immunoblot Methods 0.000 description 1
229940072221 immunoglobulins Drugs 0.000 description 1
238000001114 immunoprecipitation Methods 0.000 description 1
230000003308 immunostimulating effect Effects 0.000 description 1
238000007901 in situ hybridization Methods 0.000 description 1
238000010348 incorporation Methods 0.000 description 1
238000011534 incubation Methods 0.000 description 1
235000002279 indole-3-carbinol Nutrition 0.000 description 1
RUMVKBSXRDGBGO-UHFFFAOYSA-N indole-3-carbinol Chemical compound C1=CC=C[C]2C(CO)=CN=C21 RUMVKBSXRDGBGO-UHFFFAOYSA-N 0.000 description 1
230000036512 infertility Effects 0.000 description 1
230000028709 inflammatory response Effects 0.000 description 1
229940025708 injectable product Drugs 0.000 description 1
229910052500 inorganic mineral Inorganic materials 0.000 description 1
229940125396 insulin Drugs 0.000 description 1
230000000968 intestinal effect Effects 0.000 description 1
238000001361 intraarterial administration Methods 0.000 description 1
230000003834 intracellular effect Effects 0.000 description 1
238000001990 intravenous administration Methods 0.000 description 1
238000011835 investigation Methods 0.000 description 1
150000002500 ions Chemical class 0.000 description 1
208000028867 ischemia Diseases 0.000 description 1
CJWQYWQDLBZGPD-UHFFFAOYSA-N isoflavone Natural products C1=C(OC)C(OC)=CC(OC)=C1C1=COC2=C(C=CC(C)(C)O3)C3=C(OC)C=C2C1=O CJWQYWQDLBZGPD-UHFFFAOYSA-N 0.000 description 1
150000002515 isoflavone derivatives Chemical class 0.000 description 1
235000008696 isoflavones Nutrition 0.000 description 1
MWDZOUNAPSSOEL-UHFFFAOYSA-N kaempferol Natural products OC1=C(C(=O)c2cc(O)cc(O)c2O1)c3ccc(O)cc3 MWDZOUNAPSSOEL-UHFFFAOYSA-N 0.000 description 1
210000002510 keratinocyte Anatomy 0.000 description 1
150000002576 ketones Chemical class 0.000 description 1
208000037806 kidney injury Diseases 0.000 description 1
230000024631 kidney morphogenesis Effects 0.000 description 1
150000002605 large molecules Chemical class 0.000 description 1
230000003902 lesion Effects 0.000 description 1
210000003041 ligament Anatomy 0.000 description 1
239000006193 liquid solution Substances 0.000 description 1
239000006194 liquid suspension Substances 0.000 description 1
239000003589 local anesthetic agent Substances 0.000 description 1
210000004072 lung Anatomy 0.000 description 1
235000012680 lutein Nutrition 0.000 description 1
229960005375 lutein Drugs 0.000 description 1
239000001656 lutein Substances 0.000 description 1
KBPHJBAIARWVSC-RGZFRNHPSA-N lutein Chemical compound C([C@H](O)CC=1C)C(C)(C)C=1\C=C\C(\C)=C\C=C\C(\C)=C\C=C\C=C(/C)\C=C\C=C(/C)\C=C\[C@H]1C(C)=C[C@H](O)CC1(C)C KBPHJBAIARWVSC-RGZFRNHPSA-N 0.000 description 1
ORAKUVXRZWMARG-WZLJTJAWSA-N lutein Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C1=C(C)CCCC1(C)C)C=CC=C(/C)C=CC2C(=CC(O)CC2(C)C)C ORAKUVXRZWMARG-WZLJTJAWSA-N 0.000 description 1
229920002521 macromolecule Polymers 0.000 description 1
238000007898 magnetic cell sorting Methods 0.000 description 1
230000014759 maintenance of location Effects 0.000 description 1
238000004949 mass spectrometry Methods 0.000 description 1
230000001404 mediated effect Effects 0.000 description 1
238000002844 melting Methods 0.000 description 1
230000008018 melting Effects 0.000 description 1
102000006240 membrane receptors Human genes 0.000 description 1
108020004084 membrane receptors Proteins 0.000 description 1
WSFSSNUMVMOOMR-NJFSPNSNSA-N methanone Chemical compound O=[14CH2] WSFSSNUMVMOOMR-NJFSPNSNSA-N 0.000 description 1
238000010208 microarray analysis Methods 0.000 description 1
230000000813 microbial effect Effects 0.000 description 1
239000011859 microparticle Substances 0.000 description 1
210000000110 microvilli Anatomy 0.000 description 1
230000027939 micturition Effects 0.000 description 1
235000010755 mineral Nutrition 0.000 description 1
239000011707 mineral Substances 0.000 description 1
230000009149 molecular binding Effects 0.000 description 1
230000001002 morphogenetic effect Effects 0.000 description 1
230000000877 morphologic effect Effects 0.000 description 1
230000004899 motility Effects 0.000 description 1
229940051875 mucins Drugs 0.000 description 1
210000004877 mucosa Anatomy 0.000 description 1
238000011512 multiplexed immunoassay Methods 0.000 description 1
210000002464 muscle smooth vascular Anatomy 0.000 description 1
FGGSNQOBRJVAKL-UHFFFAOYSA-N n-[4-(2,4-dimethyl-thiazol-5-yl)-pyrimidin-2-yl]-n',n'-dimethyl-benzene-1,4-diamine Chemical compound C1=CC(N(C)C)=CC=C1NC1=NC=CC(C2=C(N=C(C)S2)C)=N1 FGGSNQOBRJVAKL-UHFFFAOYSA-N 0.000 description 1
239000002105 nanoparticle Substances 0.000 description 1
239000006225 natural substrate Substances 0.000 description 1
239000006199 nebulizer Substances 0.000 description 1
239000013642 negative control Substances 0.000 description 1
210000003360 nephrocyte Anatomy 0.000 description 1
231100000637 nephrotoxin Toxicity 0.000 description 1
210000000933 neural crest Anatomy 0.000 description 1
230000001537 neural effect Effects 0.000 description 1
231100000252 nontoxic Toxicity 0.000 description 1
230000003000 nontoxic effect Effects 0.000 description 1
238000003199 nucleic acid amplification method Methods 0.000 description 1
229920000620 organic polymer Polymers 0.000 description 1
230000008520 organization Effects 0.000 description 1
230000003204 osmotic effect Effects 0.000 description 1
235000006408 oxalic acid Nutrition 0.000 description 1
229940116315 oxalic acid Drugs 0.000 description 1
230000003647 oxidation Effects 0.000 description 1
238000007254 oxidation reaction Methods 0.000 description 1
125000005489 p-toluenesulfonic acid group Chemical class 0.000 description 1
FJKROLUGYXJWQN-UHFFFAOYSA-N papa-hydroxy-benzoic acid Natural products OC(=O)C1=CC=C(O)C=C1 FJKROLUGYXJWQN-UHFFFAOYSA-N 0.000 description 1
230000003076 paracrine Effects 0.000 description 1
WTWWXOGTJWMJHI-UHFFFAOYSA-N perflubron Chemical compound FC(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)Br WTWWXOGTJWMJHI-UHFFFAOYSA-N 0.000 description 1
229960001217 perflubron Drugs 0.000 description 1
239000007793 ph indicator Substances 0.000 description 1
239000000546 pharmaceutical excipient Substances 0.000 description 1
230000000144 pharmacologic effect Effects 0.000 description 1
238000002135 phase contrast microscopy Methods 0.000 description 1
ISWSIDIOOBJBQZ-UHFFFAOYSA-N phenol group Chemical group C1(=CC=CC=C1)O ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 description 1
229960003531 phenolsulfonphthalein Drugs 0.000 description 1
102000020233 phosphotransferase Human genes 0.000 description 1
230000000704 physical effect Effects 0.000 description 1
230000035479 physiological effects, processes and functions Effects 0.000 description 1
235000002949 phytic acid Nutrition 0.000 description 1
229940068041 phytic acid Drugs 0.000 description 1
239000000467 phytic acid Substances 0.000 description 1
235000002677 phytofluene Nutrition 0.000 description 1
OVSVTCFNLSGAMM-UZFNGAIXSA-N phytofluene Chemical compound CC(C)=CCCC(C)=CCCC(C)=CCCC(C)=CC=C\C=C(/C)\C=C\C=C(C)CCC=C(C)CCC=C(C)C OVSVTCFNLSGAMM-UZFNGAIXSA-N 0.000 description 1
ZYSFBWMZMDHGOJ-SGKBLAECSA-N phytofluene Natural products CC(=CCCC(=CCCC(=CCCC(=CC=C/C=C(C)/CCC=C(/C)C=CC=C(/C)CCC=C(C)C)C)C)C)C ZYSFBWMZMDHGOJ-SGKBLAECSA-N 0.000 description 1
210000002826 placenta Anatomy 0.000 description 1
230000003169 placental effect Effects 0.000 description 1
230000033885 plasminogen activation Effects 0.000 description 1
229920003023 plastic Polymers 0.000 description 1
239000004033 plastic Substances 0.000 description 1
210000000557 podocyte Anatomy 0.000 description 1
231100000614 poison Toxicity 0.000 description 1
229920001983 poloxamer Polymers 0.000 description 1
229920001643 poly(ether ketone) Polymers 0.000 description 1
229920001200 poly(ethylene-vinyl acetate) Polymers 0.000 description 1
229920001606 poly(lactic acid-co-glycolic acid) Polymers 0.000 description 1
229920002627 poly(phosphazenes) Polymers 0.000 description 1
229920002492 poly(sulfone) Polymers 0.000 description 1
229920002239 polyacrylonitrile Polymers 0.000 description 1
229920002647 polyamide Polymers 0.000 description 1
229920002312 polyamide-imide Polymers 0.000 description 1
239000004417 polycarbonate Substances 0.000 description 1
229920000515 polycarbonate Polymers 0.000 description 1
229920000570 polyether Polymers 0.000 description 1
229920006393 polyether sulfone Polymers 0.000 description 1
229920002530 polyetherether ketone Polymers 0.000 description 1
229920001601 polyetherimide Polymers 0.000 description 1
229920001223 polyethylene glycol Polymers 0.000 description 1
239000004633 polyglycolic acid Substances 0.000 description 1
229920001721 polyimide Polymers 0.000 description 1
ODGAOXROABLFNM-UHFFFAOYSA-N polynoxylin Chemical compound O=C.NC(N)=O ODGAOXROABLFNM-UHFFFAOYSA-N 0.000 description 1
229920000098 polyolefin Polymers 0.000 description 1
229920001184 polypeptide Polymers 0.000 description 1
150000008442 polyphenolic compounds Chemical class 0.000 description 1
229920001955 polyphenylene ether Polymers 0.000 description 1
229920000069 polyphenylene sulfide Polymers 0.000 description 1
229920001155 polypropylene Polymers 0.000 description 1
229920001296 polysiloxane Polymers 0.000 description 1
229920001343 polytetrafluoroethylene Polymers 0.000 description 1
239000004810 polytetrafluoroethylene Substances 0.000 description 1
229920002635 polyurethane Polymers 0.000 description 1
239000004814 polyurethane Substances 0.000 description 1
229920002451 polyvinyl alcohol Polymers 0.000 description 1
229920002981 polyvinylidene fluoride Polymers 0.000 description 1
239000013641 positive control Substances 0.000 description 1
230000013155 positive regulation of cell migration Effects 0.000 description 1
239000011591 potassium Substances 0.000 description 1
229910052700 potassium Inorganic materials 0.000 description 1
238000001556 precipitation Methods 0.000 description 1
239000002243 precursor Substances 0.000 description 1
230000003449 preventive effect Effects 0.000 description 1
230000001686 pro-survival effect Effects 0.000 description 1
238000012545 processing Methods 0.000 description 1
230000001737 promoting effect Effects 0.000 description 1
230000000069 prophylactic effect Effects 0.000 description 1
238000000159 protein binding assay Methods 0.000 description 1
229940116540 protein supplement Drugs 0.000 description 1
235000005974 protein supplement Nutrition 0.000 description 1
YQUVCSBJEUQKSH-UHFFFAOYSA-N protochatechuic acid Natural products OC(=O)C1=CC=C(O)C(O)=C1 YQUVCSBJEUQKSH-UHFFFAOYSA-N 0.000 description 1
238000000746 purification Methods 0.000 description 1
238000004445 quantitative analysis Methods 0.000 description 1
235000005875 quercetin Nutrition 0.000 description 1
229960001285 quercetin Drugs 0.000 description 1
230000009257 reactivity Effects 0.000 description 1
NPCOQXAVBJJZBQ-UHFFFAOYSA-N reduced coenzyme Q9 Natural products COC1=C(O)C(C)=C(CC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)C)C(O)=C1OC NPCOQXAVBJJZBQ-UHFFFAOYSA-N 0.000 description 1
239000004627 regenerated cellulose Substances 0.000 description 1
238000012429 release testing Methods 0.000 description 1
201000002793 renal fibrosis Diseases 0.000 description 1
230000010076 replication Effects 0.000 description 1
238000011160 research Methods 0.000 description 1
210000002345 respiratory system Anatomy 0.000 description 1
235000021283 resveratrol Nutrition 0.000 description 1
229940016667 resveratrol Drugs 0.000 description 1
230000000717 retained effect Effects 0.000 description 1
230000002441 reversible effect Effects 0.000 description 1
235000002020 sage Nutrition 0.000 description 1
229960004889 salicylic acid Drugs 0.000 description 1
231100000241 scar Toxicity 0.000 description 1
230000007017 scission Effects 0.000 description 1
229910052711 selenium Inorganic materials 0.000 description 1
239000011669 selenium Substances 0.000 description 1
235000011649 selenium Nutrition 0.000 description 1
210000000582 semen Anatomy 0.000 description 1
238000012163 sequencing technique Methods 0.000 description 1
102000015340 serglycin Human genes 0.000 description 1
108010050065 serglycin Proteins 0.000 description 1
238000003196 serial analysis of gene expression Methods 0.000 description 1
230000019491 signal transduction Effects 0.000 description 1
210000005122 simple epithelium Anatomy 0.000 description 1
239000002356 single layer Substances 0.000 description 1
239000001488 sodium phosphate Substances 0.000 description 1
229910000162 sodium phosphate Inorganic materials 0.000 description 1
229940054269 sodium pyruvate Drugs 0.000 description 1
238000013112 stability test Methods 0.000 description 1
238000010186 staining Methods 0.000 description 1
230000003068 static effect Effects 0.000 description 1
239000008227 sterile water for injection Substances 0.000 description 1
230000001954 sterilising effect Effects 0.000 description 1
238000004659 sterilization and disinfection Methods 0.000 description 1
230000000638 stimulation Effects 0.000 description 1
229960002317 succinimide Drugs 0.000 description 1
239000005720 sucrose Substances 0.000 description 1
235000000346 sugar Nutrition 0.000 description 1
150000008163 sugars Chemical class 0.000 description 1
125000000542 sulfonic acid group Chemical group 0.000 description 1
230000003319 supportive effect Effects 0.000 description 1
238000013268 sustained release Methods 0.000 description 1
230000002195 synergetic effect Effects 0.000 description 1
238000012385 systemic delivery Methods 0.000 description 1
230000009885 systemic effect Effects 0.000 description 1
230000035488 systolic blood pressure Effects 0.000 description 1
230000002381 testicular Effects 0.000 description 1
238000010257 thawing Methods 0.000 description 1
235000014620 theaflavin Nutrition 0.000 description 1
238000004809 thin layer chromatography Methods 0.000 description 1
230000009974 thixotropic effect Effects 0.000 description 1
229940104230 thymidine Drugs 0.000 description 1
239000003104 tissue culture media Substances 0.000 description 1
230000017423 tissue regeneration Effects 0.000 description 1
238000011200 topical administration Methods 0.000 description 1
239000003440 toxic substance Substances 0.000 description 1
239000011573 trace mineral Substances 0.000 description 1
235000013619 trace mineral Nutrition 0.000 description 1
ZIUDAKDLOLDEGU-UHFFFAOYSA-N trans-Phytofluen Natural products CC(C)=CCCC(C)CCCC(C)CC=CC(C)=CC=CC=C(C)C=CCC(C)CCCC(C)CCC=C(C)C ZIUDAKDLOLDEGU-UHFFFAOYSA-N 0.000 description 1
QURCVMIEKCOAJU-UHFFFAOYSA-N trans-isoferulic acid Natural products COC1=CC=C(C=CC(O)=O)C=C1O QURCVMIEKCOAJU-UHFFFAOYSA-N 0.000 description 1
KBPHJBAIARWVSC-XQIHNALSSA-N trans-lutein Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C1=C(C)CC(O)CC1(C)C)C=CC=C(/C)C=CC2C(=CC(O)CC2(C)C)C KBPHJBAIARWVSC-XQIHNALSSA-N 0.000 description 1
102000003601 transglutaminase Human genes 0.000 description 1
230000014616 translation Effects 0.000 description 1
230000005945 translocation Effects 0.000 description 1
108091007466 transmembrane glycoproteins Proteins 0.000 description 1
239000006163 transport media Substances 0.000 description 1
RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 description 1
229940035936 ubiquinone Drugs 0.000 description 1
210000003606 umbilical vein Anatomy 0.000 description 1
230000002485 urinary effect Effects 0.000 description 1
WKOLLVMJNQIZCI-UHFFFAOYSA-N vanillic acid Chemical compound COC1=CC(C(O)=O)=CC=C1O WKOLLVMJNQIZCI-UHFFFAOYSA-N 0.000 description 1
TUUBOHWZSQXCSW-UHFFFAOYSA-N vanillic acid Natural products COC1=CC(O)=CC(C(O)=O)=C1 TUUBOHWZSQXCSW-UHFFFAOYSA-N 0.000 description 1
230000006426 vascular sprouting Effects 0.000 description 1
229920002554 vinyl polymer Polymers 0.000 description 1
238000011179 visual inspection Methods 0.000 description 1
235000019155 vitamin A Nutrition 0.000 description 1
239000011719 vitamin A Substances 0.000 description 1
235000019166 vitamin D Nutrition 0.000 description 1
239000011710 vitamin D Substances 0.000 description 1
150000003710 vitamin D derivatives Chemical class 0.000 description 1
235000019165 vitamin E Nutrition 0.000 description 1
229940046009 vitamin E Drugs 0.000 description 1
239000011709 vitamin E Substances 0.000 description 1
229940045997 vitamin a Drugs 0.000 description 1
229940046008 vitamin d Drugs 0.000 description 1
238000010792 warming Methods 0.000 description 1
239000002699 waste material Substances 0.000 description 1
230000004584 weight gain Effects 0.000 description 1
235000019786 weight gain Nutrition 0.000 description 1
230000004580 weight loss Effects 0.000 description 1
238000001262 western blot Methods 0.000 description 1
238000012070 whole genome sequencing analysis Methods 0.000 description 1
FJHBOVDFOQMZRV-XQIHNALSSA-N xanthophyll Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C1=C(C)CC(O)CC1(C)C)C=CC=C(/C)C=CC2C=C(C)C(O)CC2(C)C FJHBOVDFOQMZRV-XQIHNALSSA-N 0.000 description 1
UHVMMEOXYDMDKI-JKYCWFKZSA-L zinc;1-(5-cyanopyridin-2-yl)-3-[(1s,2s)-2-(6-fluoro-2-hydroxy-3-propanoylphenyl)cyclopropyl]urea;diacetate Chemical compound [Zn+2].CC([O-])=O.CC([O-])=O.CCC(=O)C1=CC=C(F)C([C@H]2[C@H](C2)NC(=O)NC=2N=CC(=CC=2)C#N)=C1O UHVMMEOXYDMDKI-JKYCWFKZSA-L 0.000 description 1
OENHQHLEOONYIE-JLTXGRSLSA-N β-Carotene Chemical compound CC=1CCCC(C)(C)C=1\C=C\C(\C)=C\C=C\C(\C)=C\C=C\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C OENHQHLEOONYIE-JLTXGRSLSA-N 0.000 description 1