CN115616235A - Automatic trace sample application equipment of 1536 pore plates - Google Patents
Automatic trace sample application equipment of 1536 pore plates Download PDFInfo
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- CN115616235A CN115616235A CN202211190816.6A CN202211190816A CN115616235A CN 115616235 A CN115616235 A CN 115616235A CN 202211190816 A CN202211190816 A CN 202211190816A CN 115616235 A CN115616235 A CN 115616235A
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
- G01N35/1065—Multiple transfer devices
- G01N35/1067—Multiple transfer devices for transfer to or from containers having different spacing
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
- G01N35/1009—Characterised by arrangements for controlling the aspiration or dispense of liquids
- G01N35/1016—Control of the volume dispensed or introduced
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
- G01N2035/1027—General features of the devices
- G01N2035/1034—Transferring microquantities of liquid
- G01N2035/1039—Micropipettes, e.g. microcapillary tubes
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
- G01N2035/1027—General features of the devices
- G01N2035/1048—General features of the devices using the transfer device for another function
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
- G01N35/1065—Multiple transfer devices
- G01N2035/1076—Multiple transfer devices plurality or independently movable heads
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- Life Sciences & Earth Sciences (AREA)
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- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
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- Automatic Analysis And Handling Materials Therefor (AREA)
Abstract
The invention relates to the technical field of automatic liquid distribution, in particular to an automatic micro-sample application device of a 1536-pore plate, which comprises eight liquid transfer pipelines and peristaltic pumps arranged in the middle of each liquid transfer pipeline, wherein the peristaltic pumps provide power for liquid to flow in the corresponding liquid transfer pipelines; liquid inlet ends of the liquid transfer pipelines are respectively provided with liquid suction pipes, and the liquid suction pipes on the eight liquid transfer pipelines form fixed intervals through the first supporting mechanism so as to meet the hole-to-hole distance of a 96-hole plate or an 8-connection pipe; the sample application ends of the liquid transfer pipelines are provided with steel needle tubes, and the steel needle tubes on the eight liquid transfer pipelines form fixed intervals through the second supporting mechanism so as to meet the sample application requirement of the target plate; the invention can conveniently absorb liquid from the source plate and sample the liquid to the target plate, and can adopt sodium hypochlorite or high-purity water to clean different reagents so as to avoid cross contamination; the suction head is not required to be loaded, the leakage problem does not exist, a special chip is not required, the electromagnetic valve is not required, and the equipment cost and the use cost of materials are greatly reduced.
Description
Technical Field
The invention relates to the technical field of automatic liquid distribution, in particular to an automatic micro-sample application device of a 1536-pore plate.
Background
The research of modern biotechnology, synthetic biology and chemical biology often requires the handling of a large number of samples, and the handling of these samples places high demands on throughput, accuracy and timeliness. The manual liquid split charging, transferring, distributing and other operations not only bring great workload to scientific research personnel, but also cause experimental errors and low efficiency. Therefore, scientific research personnel develop an automatic liquid transfer workstation applied to the field of biological research, and the existing automatic liquid transfer workstation can realize the operations of ordinary liquid transfer, mixed liquid transfer, continuous liquid transfer, reverse liquid transfer and the like, has high precision and convenient operation, and has important significance for reducing manpower and improving the working efficiency of the scientific research personnel.
The automated pipetting stations currently used in biological applications include four types:
1) Automated pipetting stations holding 8-channel or 96-channel loading tips, pipetting in the range of 2 μ L to 1000 μ L, have the disadvantage of: the loading of the pipette tip is required, the minimum pipetting volume of the system is 2 mu L (CV is less than 5%) due to the problems of the viscosity, the pore size, the loading airtightness and the like of the pipette tip, the leakage problem exists in the long-term use, and the system can only be used for the pipetting work of 96-well plates and 384-well plates at most.
2) Automated pipetting stations for pipette tips with 4 or 8 channels with movable spacing, pipetting in the range of 2 to 1000. Mu.L, have the disadvantage of: the loading of the pipette tip is required, the minimum pipetting volume of the system is 2 mu L (CV is less than 5%) due to the problems of the viscosity, the pore size, the loading airtightness and the like of the pipette tip, the leakage problem exists when the system is used for a long time, and the system can only be used for the pipetting work of 96-well plates and 384-well plates at most.
3) The fixed 8-channel steel needle tube type automatic liquid separator is mainly used for separating liquid from a 96-pore plate or a 384-pore plate, the liquid transfer range is 5 mu L to 9999 mu L, and the system has the following defects: the technology adopts a peristaltic pump with larger specification, the minimum pipetting volume is 5 mu L (CV is less than 5%), and the technology can only be used for pipetting of 96-well plates and 384-well plates at most, can only be used for separating the same liquid, and cannot be used for spotting or pipetting different reagents or samples.
4) The fixed 8-channel steel needle tube is combined with a solenoid valve type nano-liter automatic sample applicator, is mainly used for sample application of 384-well plates, 1536-well plates and 5184-well plates, has the liquid transfer range of 50nL to 10 muL, and has the defects that a solenoid valve is required as a control device, and the cost is high; the application of the 5184 pore plate requires a special chip, is high in cost and unstable in the environment with high temperature and low humidity, and the needle tube is too thin and easily causes blockage.
Disclosure of Invention
The embodiment of the invention aims to provide an automatic micro-spotting device for 1536 pore plates, which can not only overcome the problem of leakage after long-term use caused by the fact that an existing automatic pipetting workstation needs to load a pipette tip, but also avoid the use of an expensive special chip to meet the spotting requirement of 1536 pore plates, and has the advantage of low cost.
In order to achieve the purpose, the invention adopts the following technical scheme:
an automatic micro sample application device of a 1536 pore plate comprises eight liquid transferring pipelines and peristaltic pumps arranged in the middle of each liquid transferring pipeline, wherein the peristaltic pumps provide power for liquid to flow in the corresponding liquid transferring pipelines;
liquid inlet ends of the liquid transfer pipelines are respectively provided with liquid suction pipes, and the liquid suction pipes on the eight liquid transfer pipelines form fixed intervals through the first supporting mechanism so as to meet the hole-to-hole distance of a 96-hole plate or an 8-connection pipe;
the sample application end of the liquid transfer pipeline is provided with a steel needle tube, and the steel needle tubes on the eight liquid transfer pipelines form fixed intervals through a second supporting mechanism so as to meet the sample application requirement of the target plate.
In a further aspect, the target plate is downwardly compatible with 384-well plates and 96-well plates.
In a further technical scheme, the pipette is made of a DNA low adsorption plastic material.
In a further technical scheme, an inner coating which is corrosion-resistant and low in absorption of nucleic acid and other biochemical reagents is added on the inner wall of the steel needle tube.
In a further aspect, the peristaltic pump is a small scale to meet pipetting ranges of 500nL to 100 μ L.
In a further technical scheme, the second supporting mechanism comprises a supporting plate which is transversely extended and arranged, a plurality of rows of spacing holes which are arranged at intervals and have fixed intervals are arranged on the supporting plate for inserting the steel needle tube, and an inverted truncated cone-shaped spacing sleeve fixed on the steel needle tube is in spacing fit with the spacing holes;
wherein, a communicating part is arranged between the corresponding limit holes of the adjacent rows for the movement of the steel needle tube.
In a further technical scheme, the upper ends of the eight steel needle tubes are fixedly connected together through an elastic piece.
In a further technical scheme, a supporting plate is further arranged on the sample application equipment and used for supporting the target plate, the inner side edge of the supporting plate is connected with a driving mechanism, and the driving mechanism can drive the supporting plate to move on the horizontal plane to supply the steel needle tube to carry out sample application operation.
In a further technical scheme, the bottom of the supporting plate is provided with a sliding block which is matched with a guide rail arranged on the sample application equipment in a sliding and guiding way.
In a further technical scheme, a positioning part is arranged on the supporting plate for positioning and placing the target plate.
Compared with the prior art, the invention has the following technical effects:
the automatic micro sample application equipment of the 1536 pore plate can conveniently absorb liquid from a source plate and apply samples to a target plate, and different reagents can be cleaned by sodium hypochlorite or high-purity water to avoid cross contamination;
the automatic micro sample application equipment of the 1536 pore plate provided by the invention does not need to load a suction head, does not have the problem of liquid leakage after long-term use, does not need a special chip, and does not need to be provided with an electromagnetic valve, thereby greatly reducing the equipment cost and the material use cost.
Drawings
FIG. 1 shows a schematic diagram of an automated micro-spotting device that is a 1536-well plate according to an embodiment of the present invention;
fig. 2 is a schematic structural diagram of an upper support plate of a second support mechanism according to an embodiment of the present invention;
FIG. 3 is a schematic structural view of a steel needle cannula provided in accordance with an embodiment of the present invention;
the reference numbers in the figures illustrate: 1. a source plate; 2. a target plate; 10. a liquid transfer pipeline; 11. a peristaltic pump; 12. a pipette; 13. a steel needle tube; 131. a truncated cone-shaped limiting sleeve; 132. an elastic member; 20. a first support mechanism; 30. a second support mechanism; 31. a support plate; 32. a limiting hole; 321. a communicating portion; 40. a housing; 41. a sample application operating area; 42. a component mounting area; 43. a support frame; 50. supporting plates; 60. and a waste liquid collecting tank.
Detailed Description
In order to make the technical means, the creation characteristics, the achievement purposes and the effects of the invention easy to understand, the invention is further clarified by combining the specific drawings.
It will be understood that when an element is referred to as being "secured to" another element, it can be directly on the other element or intervening elements may also be present. When an element is referred to as being "connected" to another element, it can be directly connected to the other element or intervening elements may also be present. The terms "vertical," "horizontal," "left," "right," and the like as used herein are for illustrative purposes only and do not denote a unique embodiment.
Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs. The terminology used herein in the description of the invention is for the purpose of describing particular embodiments only and is not intended to be limiting of the invention. As used herein, the term "and/or" includes any and all combinations of one or more of the associated listed items.
As mentioned above, the invention provides an automatic micro-spotting device with 1536-well plates, which comprises eight pipetting pipelines 10 and a peristaltic pump 11 arranged in the middle of each pipetting pipeline 10, wherein the peristaltic pump 11 provides power for liquid to flow in the corresponding pipetting pipeline 10;
liquid suction pipes 12 are arranged at the liquid inlet ends of the liquid transfer pipelines 10, and the liquid suction pipes 12 on the eight liquid transfer pipelines 10 form fixed intervals through first supporting mechanisms 20 so as to meet the hole-to-hole distance of a 96-hole plate or 8-connected pipes;
the sample application end of the pipette 10 is provided with a steel needle tube 13, and the steel needle tubes 13 on the eight pipette tubes 10 form a fixed distance through the second supporting mechanism 30 to meet the sample application requirement of the target plate 2.
In the technical scheme provided by the invention, the peristaltic pumps 11 are respectively arranged on the liquid transfer pipelines 10, namely, each channel has an independent fluid pipeline to realize independent liquid transfer function, and each liquid transfer pipeline 10 can independently realize operations of liquid suction at one end and sample application at one end, thereby ensuring the stability during liquid transfer.
In addition, the sample application equipment provided by the invention has the advantages that the sample application end is connected with the steel needle tube 13, so that a suction head does not need to be loaded, and the problem of liquid leakage after the suction head is used for a long time in the prior art is solved; in addition, the sample application device provided by the invention does not need a special chip to meet the sample application requirements of 1536 pore plates or 5184 pore plates, and an electromagnetic valve is not needed, so that the cost of the device and the use cost of materials are greatly reduced.
FIG. 1 is a schematic diagram of an automated micro-spotting device with 1536-well plate according to an embodiment of the present invention, the automated micro-spotting device includes a housing 40, the housing 40 has a spotting operation area 41 on a side close to an operator and a component mounting area 42 on a side far from the operator;
the pipetting pipeline 10, the pipette 12 and the steel needle 13 are all arranged in the sample application operation area 41 to complete sample application, liquid separation and other operations, and the component mounting area 42 is used for arranging components such as electrical elements, a driving mechanism and the like.
The peristaltic pump 11 is fixed on a support frame 43 above the print application zone 41, and one end of the support frame 43 extends into the component mounting zone 42.
The first support mechanism 20 and the second support mechanism 30 both extend from the component mounting area 42 to above the spot-like operation area 41, and the first support mechanism 20 is vertically movable to bring the pipette 12 close to or away from the source plate 1;
the second supporting mechanism 30 has a fixed distance with the target plate 2 to be spotted, and when spotting and liquid separation are performed, the steel needle tube 13 can perform spotting and liquid separation on different positions through the movement of the target plate 2.
It should be noted that, in the present invention, the upper and lower positions of the second supporting mechanism 30 are precisely adjusted by a hardware engineer through calibration before the equipment leaves the factory, and compared with the up-down, front-back or left-right movement of the pipetting head in the prior art, the upper and lower positions of the second supporting mechanism 30 in the present invention are relatively determined, which effectively prevents the problem that the steel needle tube 13 may be damaged due to impact during the moving process, and simultaneously avoids the repeated friction when the steel needle tube 13 is moved to drive the pipetting pipeline 10 to drag, thereby reducing the loss; in addition, due to the relative determination of the upper and lower positions of the second supporting mechanism 30, the problems of reagent serial holes and pollution caused by insufficient positioning precision due to long-term movement of the pipetting head in the prior art are solved.
It should be noted that, in the present invention, the driving mechanism for realizing the vertical movement of the first supporting mechanism 20 may adopt the prior art in the field, and the present invention is not described herein again.
In the invention, the target plate 2 is a 1536-well plate, and the target plate 2 is compatible with a 384-well plate and a 96-well plate downwards.
According to the spotting device provided by the present invention, in some embodiments, the pipette 12 is made of a DNA low adsorption plastic material.
In the invention, the pipette 12 is fixed by the first support mechanism 20 to form a fixed distance which is in accordance with the hole distance of a conventional 96-hole plate or 8-tube, so that the pipette can suck reagent from the 96-hole plate or 8-tube, and can also suck sodium hypochlorite solution or ultrapure water from a cleaning pipeline from a cleaning tank.
In some embodiments, the inner wall of the steel needle tubing 13 is provided with an inner coating that is corrosion resistant and low in absorption of nucleic acids and other biochemical reagents.
In the present invention, the peristaltic pump 11 is a small-range peristaltic pump to satisfy a pipetting range of 500nL to 100. Mu.L.
In the invention, the peristaltic pump 11 realizes peristaltic motion by a motor, the motor is controlled by a control board, and the control board is in butt joint with the control program. When the device is used specifically, parameters are set on the control board through a computer program, and the peristaltic times of the peristaltic pump 11 are controlled through the parameters so as to adjust the sample application or liquid transfer volume.
In some embodiments, as shown in fig. 2 and 3, the second supporting mechanism 30 includes a supporting plate 31 extending transversely, the supporting plate 31 is provided with a plurality of rows of spacing holes 32 arranged at intervals and having fixed intervals for inserting the steel needle tube 13 therein, and the steel needle tube 13 is fixed with an inverted truncated cone-shaped spacing sleeve 131 which forms a spacing fit with the spacing holes 32; wherein, a communicating part 321 is arranged between the corresponding limit holes 32 of the adjacent rows for the movement of the steel needle tube 13.
In specific use, the steel needle tube 13 is manually adjusted to the limiting holes 32 in different rows to meet the sample application requirements of different target plates 2. Specifically, the steel needle tube 13 is pulled out upward by a certain distance and moves along the communicating part 321 between the adjacent rows of limiting holes 32, and after the steel needle tube 13 moves to the limiting holes 32 of the target row, the steel needle tube 13 is put down, so that the circular truncated cone-shaped limiting sleeve 131 sleeved on the steel needle tube 13 and the limiting holes 32 form extrusion limiting fit, and the stability and reliability in the subsequent sample application are ensured. In the invention, the limiting holes 32 are arranged in a plurality of rows at intervals, each row of limiting holes 32 has a fixed interval, and the communicating parts 321 are arranged between the limiting holes 32 in different rows, so that the position of the steel needle tube 13 can be conveniently adjusted and fixed, and the sample application requirements of different target plates 2 are further met.
Further, in the present invention, the upper ends of the eight steel needle tubes 13 are fixedly connected together through an elastic member 132. Through the arrangement of the elastic member 132, the steel needle tubes 13 in a row, for example, eight steel needle tubes 13, can be moved simultaneously at one time, the elastic member 132 can stretch and retract to meet the fixing requirements of the steel needle tubes 13 in the limiting holes 32 with different fixed intervals, preferably, when the steel needle tubes 13 are located in the limiting holes 32 with the lowest fixed interval, the elastic member 132 is in a non-drawing state, that is, when the steel needle tubes 13 move into the limiting holes 32 with other fixed intervals, the elastic member 132 is in a drawing state, and is matched with the extrusion fit of the circular truncated cone-shaped limiting sleeve 131 and the limiting holes 32, so that the fixing effect of the steel needle tubes 13 in the limiting holes 32 is ensured, the play problem of the steel needle tubes 13 during sample application is effectively prevented, and the stability of sample application is ensured.
In the invention, the sample application device is also provided with a support plate 50 for supporting the target plate 2, the inner side of the support plate 50 is connected with a driving mechanism, and the driving mechanism can drive the support plate 50 to move on the horizontal plane for the steel needle tube 13 to perform sample application operation. It should be noted that, in the present invention, the driving mechanism is used to drive the supporting plate 50 to move on the horizontal plane, so as to perform the spotting operation on the target plate 2 according to the working rhythm of the peristaltic pump 11.
In a specific embodiment of the present invention, the supporting plate 50 can support the target plate 2 to move in a large scale in the left-right direction and move in a small scale in the front-back position; specifically, the slide block guide rail assemblies are respectively arranged in the left-right direction and the front-back direction, and the driving assemblies are correspondingly arranged, so that the operation is simple and convenient, and the invention is not repeated herein. Compared with the arrangement mode that the sample application mode only moves in the left-right direction in a large scale and does not move in the front-back position in the prior art, the sample application mode in the invention changes from a mode of moving from left to right, from top to bottom, then from bottom to top, then from top to bottom, and then from top to bottom, so that various combinations are realized for different samples and reaction liquids, and the application type of the scheme is greatly improved.
Further, in the invention, the bottom of the supporting plate 50 is provided with a sliding block which forms sliding guide fit with a guide rail arranged on the sample application device. Through the cooperation of this slider and guide rail, guaranteed the stability of support plate 50 in the removal process.
Furthermore, in the present invention, the supporting plate 50 is provided with a positioning portion for positioning the target board 2. By the arrangement of the positioning portion, the target board 2 can be quickly placed to realize the positioning of the A1 hole.
In the invention, the sample application device is also provided with a waste liquid collecting tank 60, and the waste liquid collecting tank 60 is connected with a waste liquid cylinder through a conduit.
The foregoing shows and describes the general principles, essential features, and inventive features of this invention. It will be understood by those skilled in the art that the present invention is not limited to the embodiments described above, which are described in the specification and illustrated only to illustrate the principle of the present invention, but that various changes and modifications may be made therein without departing from the spirit and scope of the present invention, which fall within the scope of the invention as claimed. The scope of the invention is defined by the appended claims and equivalents thereof.
Claims (10)
1. An automatic micro sample application device of a 1536 pore plate is characterized by comprising eight liquid transferring pipelines and a peristaltic pump arranged in the middle of each liquid transferring pipeline, wherein the peristaltic pump provides power for liquid to flow in the corresponding liquid transferring pipeline;
liquid inlet ends of the liquid transferring pipelines are provided with liquid absorbing pipes, and the liquid absorbing pipes on the eight liquid transferring pipelines form fixed intervals through a first supporting mechanism so as to meet the hole-to-hole distance of a 96-hole plate or 8-connected pipes;
the sample application end of the liquid transfer pipeline is provided with a steel needle tube, and the steel needle tubes on the eight liquid transfer pipelines form fixed intervals through a second supporting mechanism so as to meet the sample application requirement of the target plate.
2. The automated micro spotting device of 1536-well plates of claim 1 wherein the target plate is downward compatible with 384-well and 96-well plates.
3. The automated micro spotting device of 1536 well plates of claim 1 wherein the pipette is made of DNA low adsorption plastic material.
4. The automated micro spotting device of 1536 well plates of claim 1 wherein the inner wall of the steel needle tube is coated with an inner coating that is corrosion resistant and low absorption of nucleic acids and other biochemical reagents.
5. An automated microspotting device as claimed in claim 1 wherein the peristaltic pump is miniaturised to meet pipetting ranges of 500nL to 100 μ L.
6. The automated micro-spotting device of 1536 well plates of claim 1, wherein the second support mechanism comprises a support plate extending transversely, the support plate is provided with a plurality of rows of spacing holes arranged at intervals and having fixed intervals for inserting steel needle tubes therein, and inverted truncated cone-shaped spacing sleeves fixed on the steel needle tubes form spacing fit with the spacing holes;
wherein, a communicating part is arranged between the corresponding limiting holes of the adjacent rows for the movement of the steel needle tube.
7. An automated micro-spotting device using 1536 well-plates as described in claim 6 wherein the upper ends of the eight steel pins are fixedly connected together via an elastic member.
8. The automated micro-spotting device with 1536-well plates of claim 1, wherein a supporting plate is further provided on the spotting device for supporting the target plate, the inner side of the supporting plate is connected to a driving mechanism, and the driving mechanism can drive the supporting plate to move on a horizontal plane for the steel needle tube to perform spotting operation.
9. An automated micro-spotting device with 1536 well-plates according to claim 8 wherein the bottom of the support plate is provided with slide blocks to form a sliding guide fit with guide rails arranged on the spotting device.
10. The automated micro spotting apparatus of 1536 pore plates of claim 8, wherein the support plate is provided with a positioning part for positioning the target plate.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202211190816.6A CN115616235A (en) | 2022-09-28 | 2022-09-28 | Automatic trace sample application equipment of 1536 pore plates |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202211190816.6A CN115616235A (en) | 2022-09-28 | 2022-09-28 | Automatic trace sample application equipment of 1536 pore plates |
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| Publication Number | Publication Date |
|---|---|
| CN115616235A true CN115616235A (en) | 2023-01-17 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202211190816.6A Pending CN115616235A (en) | 2022-09-28 | 2022-09-28 | Automatic trace sample application equipment of 1536 pore plates |
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| US20120195811A1 (en) * | 2011-01-28 | 2012-08-02 | Integra Biosciences Corp. | Multi-Channel Wellplate Filling System |
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| CN209997648U (en) * | 2019-02-28 | 2020-01-31 | 湖南中核环保科技有限公司 | multichannel liquid reagent separating machine |
| CN210846433U (en) * | 2019-10-07 | 2020-06-26 | 浙江中纺标检验有限公司 | Multi-pipeline liquid transfer device |
| CN212681041U (en) * | 2020-06-16 | 2021-03-12 | 南京中科通仪科技有限公司 | Multichannel pipetting device |
| CN213085463U (en) * | 2020-09-11 | 2021-04-30 | 深圳市奥美顿科技有限公司 | Automatic multichannel liquid separation appearance of changing |
| CN216322025U (en) * | 2021-11-30 | 2022-04-19 | 苏州爱科仕智造科技有限公司 | Multi-degree-of-freedom variable-interval four-channel liquid transfer device |
| CN216654613U (en) * | 2021-12-03 | 2022-06-03 | 上海爱翱生物科技有限公司 | Automatic liquid separation instrument |
| CN217093560U (en) * | 2022-04-13 | 2022-08-02 | 杭州奥铂智能仪器有限公司 | Quick liquid separating equipment |
-
2022
- 2022-09-28 CN CN202211190816.6A patent/CN115616235A/en active Pending
Patent Citations (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20120195811A1 (en) * | 2011-01-28 | 2012-08-02 | Integra Biosciences Corp. | Multi-Channel Wellplate Filling System |
| CN107132368A (en) * | 2017-07-03 | 2017-09-05 | 陆思远 | A kind of new liquid-transfering device |
| CN209997648U (en) * | 2019-02-28 | 2020-01-31 | 湖南中核环保科技有限公司 | multichannel liquid reagent separating machine |
| CN210846433U (en) * | 2019-10-07 | 2020-06-26 | 浙江中纺标检验有限公司 | Multi-pipeline liquid transfer device |
| CN212681041U (en) * | 2020-06-16 | 2021-03-12 | 南京中科通仪科技有限公司 | Multichannel pipetting device |
| CN213085463U (en) * | 2020-09-11 | 2021-04-30 | 深圳市奥美顿科技有限公司 | Automatic multichannel liquid separation appearance of changing |
| CN216322025U (en) * | 2021-11-30 | 2022-04-19 | 苏州爱科仕智造科技有限公司 | Multi-degree-of-freedom variable-interval four-channel liquid transfer device |
| CN216654613U (en) * | 2021-12-03 | 2022-06-03 | 上海爱翱生物科技有限公司 | Automatic liquid separation instrument |
| CN217093560U (en) * | 2022-04-13 | 2022-08-02 | 杭州奥铂智能仪器有限公司 | Quick liquid separating equipment |
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