CN115612183B - Chinese herbal medicine-supermolecule aerogel and preparation method and application thereof - Google Patents
Chinese herbal medicine-supermolecule aerogel and preparation method and application thereof Download PDFInfo
- Publication number
- CN115612183B CN115612183B CN202211154119.5A CN202211154119A CN115612183B CN 115612183 B CN115612183 B CN 115612183B CN 202211154119 A CN202211154119 A CN 202211154119A CN 115612183 B CN115612183 B CN 115612183B
- Authority
- CN
- China
- Prior art keywords
- aerogel
- herbal medicine
- chinese herbal
- supermolecule
- sodium alginate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 239000004964 aerogel Substances 0.000 title claims abstract description 77
- 238000002360 preparation method Methods 0.000 title claims abstract description 17
- 235000019504 cigarettes Nutrition 0.000 claims abstract description 65
- IXPNQXFRVYWDDI-UHFFFAOYSA-N 1-methyl-2,4-dioxo-1,3-diazinane-5-carboximidamide Chemical compound CN1CC(C(N)=N)C(=O)NC1=O IXPNQXFRVYWDDI-UHFFFAOYSA-N 0.000 claims abstract description 27
- 229920000858 Cyclodextrin Polymers 0.000 claims abstract description 27
- 235000010413 sodium alginate Nutrition 0.000 claims abstract description 27
- 239000000661 sodium alginate Substances 0.000 claims abstract description 27
- 229940005550 sodium alginate Drugs 0.000 claims abstract description 27
- HFHDHCJBZVLPGP-UHFFFAOYSA-N schardinger α-dextrin Chemical compound O1C(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(O)C2O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC2C(O)C(O)C1OC2CO HFHDHCJBZVLPGP-UHFFFAOYSA-N 0.000 claims abstract description 19
- 241000411851 herbal medicine Species 0.000 claims abstract description 17
- 238000002791 soaking Methods 0.000 claims abstract description 16
- 235000002637 Nicotiana tabacum Nutrition 0.000 claims abstract description 14
- 238000001035 drying Methods 0.000 claims abstract description 14
- -1 carboxymethyl cyclodextrin Chemical compound 0.000 claims abstract description 8
- 239000004615 ingredient Substances 0.000 claims abstract description 6
- 238000002156 mixing Methods 0.000 claims abstract description 4
- 238000002604 ultrasonography Methods 0.000 claims abstract description 3
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 claims description 24
- NOOLISFMXDJSKH-UHFFFAOYSA-N DL-menthol Natural products CC(C)C1CCC(C)CC1O NOOLISFMXDJSKH-UHFFFAOYSA-N 0.000 claims description 21
- 229940041616 menthol Drugs 0.000 claims description 21
- 238000000034 method Methods 0.000 claims description 15
- 229910000019 calcium carbonate Inorganic materials 0.000 claims description 12
- 230000001603 reducing effect Effects 0.000 claims description 11
- 239000000017 hydrogel Substances 0.000 claims description 10
- 238000003756 stirring Methods 0.000 claims description 8
- 238000005303 weighing Methods 0.000 claims description 8
- 239000012153 distilled water Substances 0.000 claims description 7
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 7
- 238000004108 freeze drying Methods 0.000 claims description 5
- PHOQVHQSTUBQQK-SQOUGZDYSA-N D-glucono-1,5-lactone Chemical compound OC[C@H]1OC(=O)[C@H](O)[C@@H](O)[C@@H]1O PHOQVHQSTUBQQK-SQOUGZDYSA-N 0.000 claims description 4
- 238000007710 freezing Methods 0.000 claims description 4
- 230000008014 freezing Effects 0.000 claims description 4
- 235000012209 glucono delta-lactone Nutrition 0.000 claims description 4
- 229960003681 gluconolactone Drugs 0.000 claims description 4
- 239000000341 volatile oil Substances 0.000 claims description 3
- 235000005979 Citrus limon Nutrition 0.000 claims description 2
- 244000131522 Citrus pyriformis Species 0.000 claims description 2
- 244000166124 Eucalyptus globulus Species 0.000 claims description 2
- 241000220317 Rosa Species 0.000 claims description 2
- 244000223014 Syzygium aromaticum Species 0.000 claims description 2
- 235000016639 Syzygium aromaticum Nutrition 0.000 claims description 2
- 240000002657 Thymus vulgaris Species 0.000 claims description 2
- 235000007303 Thymus vulgaris Nutrition 0.000 claims description 2
- 239000007788 liquid Substances 0.000 claims description 2
- 239000007787 solid Substances 0.000 claims description 2
- 239000002904 solvent Substances 0.000 claims description 2
- 239000001585 thymus vulgaris Substances 0.000 claims description 2
- 244000061176 Nicotiana tabacum Species 0.000 claims 2
- NOOLISFMXDJSKH-UTLUCORTSA-N (+)-Neomenthol Chemical compound CC(C)[C@@H]1CC[C@@H](C)C[C@@H]1O NOOLISFMXDJSKH-UTLUCORTSA-N 0.000 claims 1
- 241000427159 Achyranthes Species 0.000 claims 1
- 235000013628 Lantana involucrata Nutrition 0.000 claims 1
- 235000006677 Monarda citriodora ssp. austromontana Nutrition 0.000 claims 1
- 240000007673 Origanum vulgare Species 0.000 claims 1
- 241000208125 Nicotiana Species 0.000 abstract description 12
- 235000019640 taste Nutrition 0.000 abstract description 12
- 238000001914 filtration Methods 0.000 abstract description 10
- 230000000694 effects Effects 0.000 abstract description 8
- 239000002994 raw material Substances 0.000 abstract description 5
- 239000000126 substance Substances 0.000 abstract description 4
- 230000003472 neutralizing effect Effects 0.000 abstract description 2
- NOOLISFMXDJSKH-KXUCPTDWSA-N (-)-Menthol Chemical compound CC(C)[C@@H]1CC[C@@H](C)C[C@H]1O NOOLISFMXDJSKH-KXUCPTDWSA-N 0.000 description 21
- 239000000779 smoke Substances 0.000 description 13
- 239000002131 composite material Substances 0.000 description 7
- 238000010521 absorption reaction Methods 0.000 description 6
- 210000003800 pharynx Anatomy 0.000 description 6
- 239000003814 drug Substances 0.000 description 5
- 239000011148 porous material Substances 0.000 description 5
- 230000000391 smoking effect Effects 0.000 description 5
- UGFAIRIUMAVXCW-UHFFFAOYSA-N Carbon monoxide Chemical compound [O+]#[C-] UGFAIRIUMAVXCW-UHFFFAOYSA-N 0.000 description 4
- 238000002485 combustion reaction Methods 0.000 description 4
- 230000000052 comparative effect Effects 0.000 description 4
- 239000000499 gel Substances 0.000 description 4
- 230000036541 health Effects 0.000 description 4
- 238000001000 micrograph Methods 0.000 description 4
- 230000008569 process Effects 0.000 description 4
- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 description 3
- UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 description 3
- 238000002474 experimental method Methods 0.000 description 3
- 239000003546 flue gas Substances 0.000 description 3
- 235000013305 food Nutrition 0.000 description 3
- 239000007789 gas Substances 0.000 description 3
- 230000006872 improvement Effects 0.000 description 3
- 239000000463 material Substances 0.000 description 3
- 239000002245 particle Substances 0.000 description 3
- 230000009467 reduction Effects 0.000 description 3
- AEMOLEFTQBMNLQ-AZLKCVHYSA-N (2r,3s,4s,5s,6r)-3,4,5,6-tetrahydroxyoxane-2-carboxylic acid Chemical compound O[C@@H]1O[C@@H](C(O)=O)[C@@H](O)[C@H](O)[C@@H]1O AEMOLEFTQBMNLQ-AZLKCVHYSA-N 0.000 description 2
- AEMOLEFTQBMNLQ-SYJWYVCOSA-N (2s,3s,4s,5s,6r)-3,4,5,6-tetrahydroxyoxane-2-carboxylic acid Chemical compound O[C@@H]1O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@@H]1O AEMOLEFTQBMNLQ-SYJWYVCOSA-N 0.000 description 2
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 description 2
- 229920006221 acetate fiber Polymers 0.000 description 2
- 238000010586 diagram Methods 0.000 description 2
- 238000007865 diluting Methods 0.000 description 2
- 239000003205 fragrance Substances 0.000 description 2
- 229930195733 hydrocarbon Natural products 0.000 description 2
- 150000002430 hydrocarbons Chemical class 0.000 description 2
- LELOWRISYMNNSU-UHFFFAOYSA-N hydrogen cyanide Chemical compound N#C LELOWRISYMNNSU-UHFFFAOYSA-N 0.000 description 2
- 230000002209 hydrophobic effect Effects 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 229920000642 polymer Polymers 0.000 description 2
- 239000000047 product Substances 0.000 description 2
- 238000009210 therapy by ultrasound Methods 0.000 description 2
- 238000002211 ultraviolet spectrum Methods 0.000 description 2
- SNICXCGAKADSCV-JTQLQIEISA-N (-)-Nicotine Chemical compound CN1CCC[C@H]1C1=CC=CN=C1 SNICXCGAKADSCV-JTQLQIEISA-N 0.000 description 1
- JBIJLHTVPXGSAM-UHFFFAOYSA-N 2-naphthylamine Chemical compound C1=CC=CC2=CC(N)=CC=C21 JBIJLHTVPXGSAM-UHFFFAOYSA-N 0.000 description 1
- ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical compound [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 description 1
- 240000000031 Achyranthes bidentata Species 0.000 description 1
- 241001120493 Arene Species 0.000 description 1
- 241000512259 Ascophyllum nodosum Species 0.000 description 1
- FMMWHPNWAFZXNH-UHFFFAOYSA-N Benz[a]pyrene Chemical compound C1=C2C3=CC=CC=C3C=C(C=C3)C2=C2C3=CC=CC2=C1 FMMWHPNWAFZXNH-UHFFFAOYSA-N 0.000 description 1
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 206010019233 Headaches Diseases 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- 229930195725 Mannitol Natural products 0.000 description 1
- 244000246386 Mentha pulegium Species 0.000 description 1
- 235000016257 Mentha pulegium Nutrition 0.000 description 1
- 235000004357 Mentha x piperita Nutrition 0.000 description 1
- 241001529744 Origanum Species 0.000 description 1
- 235000011203 Origanum Nutrition 0.000 description 1
- 208000003251 Pruritus Diseases 0.000 description 1
- 238000002835 absorbance Methods 0.000 description 1
- 239000003463 adsorbent Substances 0.000 description 1
- 229910021529 ammonia Inorganic materials 0.000 description 1
- 150000004945 aromatic hydrocarbons Chemical class 0.000 description 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 239000006227 byproduct Substances 0.000 description 1
- VTJUKNSKBAOEHE-UHFFFAOYSA-N calixarene Chemical class COC(=O)COC1=C(CC=2C(=C(CC=3C(=C(C4)C=C(C=3)C(C)(C)C)OCC(=O)OC)C=C(C=2)C(C)(C)C)OCC(=O)OC)C=C(C(C)(C)C)C=C1CC1=C(OCC(=O)OC)C4=CC(C(C)(C)C)=C1 VTJUKNSKBAOEHE-UHFFFAOYSA-N 0.000 description 1
- 230000001914 calming effect Effects 0.000 description 1
- 229910052799 carbon Inorganic materials 0.000 description 1
- 229910002091 carbon monoxide Inorganic materials 0.000 description 1
- 238000003763 carbonization Methods 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 238000009833 condensation Methods 0.000 description 1
- 230000005494 condensation Effects 0.000 description 1
- 238000004132 cross linking Methods 0.000 description 1
- 150000003983 crown ethers Chemical class 0.000 description 1
- 229940097362 cyclodextrins Drugs 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000000428 dust Substances 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 239000000796 flavoring agent Substances 0.000 description 1
- 235000019634 flavors Nutrition 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 150000004676 glycans Chemical class 0.000 description 1
- 231100000869 headache Toxicity 0.000 description 1
- 235000001050 hortel pimenta Nutrition 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 229910001872 inorganic gas Inorganic materials 0.000 description 1
- 229910001410 inorganic ion Inorganic materials 0.000 description 1
- 230000009878 intermolecular interaction Effects 0.000 description 1
- 239000011630 iodine Substances 0.000 description 1
- 229910052740 iodine Inorganic materials 0.000 description 1
- 239000002085 irritant Substances 0.000 description 1
- 231100000021 irritant Toxicity 0.000 description 1
- 230000007803 itching Effects 0.000 description 1
- 210000000867 larynx Anatomy 0.000 description 1
- 239000000594 mannitol Substances 0.000 description 1
- 235000010355 mannitol Nutrition 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 210000000214 mouth Anatomy 0.000 description 1
- 210000004877 mucosa Anatomy 0.000 description 1
- 229960002715 nicotine Drugs 0.000 description 1
- SNICXCGAKADSCV-UHFFFAOYSA-N nicotine Natural products CN1CCCC1C1=CC=CN=C1 SNICXCGAKADSCV-UHFFFAOYSA-N 0.000 description 1
- 150000004767 nitrides Chemical class 0.000 description 1
- 210000001331 nose Anatomy 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 239000000825 pharmaceutical preparation Substances 0.000 description 1
- 229920001282 polysaccharide Polymers 0.000 description 1
- 239000005017 polysaccharide Substances 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 238000000197 pyrolysis Methods 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 238000001179 sorption measurement Methods 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 150000003568 thioethers Chemical class 0.000 description 1
- 238000009736 wetting Methods 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
- C08J9/00—Working-up of macromolecular substances to porous or cellular articles or materials; After-treatment thereof
- C08J9/36—After-treatment
- C08J9/40—Impregnation
-
- A—HUMAN NECESSITIES
- A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
- A24D—CIGARS; CIGARETTES; TOBACCO SMOKE FILTERS; MOUTHPIECES FOR CIGARS OR CIGARETTES; MANUFACTURE OF TOBACCO SMOKE FILTERS OR MOUTHPIECES
- A24D3/00—Tobacco smoke filters, e.g. filter-tips, filtering inserts; Filters specially adapted for simulated smoking devices; Mouthpieces for cigars or cigarettes
- A24D3/04—Tobacco smoke filters characterised by their shape or structure
- A24D3/048—Tobacco smoke filters characterised by their shape or structure containing additives
-
- A—HUMAN NECESSITIES
- A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
- A24D—CIGARS; CIGARETTES; TOBACCO SMOKE FILTERS; MOUTHPIECES FOR CIGARS OR CIGARETTES; MANUFACTURE OF TOBACCO SMOKE FILTERS OR MOUTHPIECES
- A24D3/00—Tobacco smoke filters, e.g. filter-tips, filtering inserts; Filters specially adapted for simulated smoking devices; Mouthpieces for cigars or cigarettes
- A24D3/06—Use of materials for tobacco smoke filters
- A24D3/061—Use of materials for tobacco smoke filters containing additives entrapped within capsules, sponge-like material or the like, for further release upon smoking
-
- A—HUMAN NECESSITIES
- A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
- A24D—CIGARS; CIGARETTES; TOBACCO SMOKE FILTERS; MOUTHPIECES FOR CIGARS OR CIGARETTES; MANUFACTURE OF TOBACCO SMOKE FILTERS OR MOUTHPIECES
- A24D3/00—Tobacco smoke filters, e.g. filter-tips, filtering inserts; Filters specially adapted for simulated smoking devices; Mouthpieces for cigars or cigarettes
- A24D3/06—Use of materials for tobacco smoke filters
- A24D3/062—Use of materials for tobacco smoke filters characterised by structural features
-
- A—HUMAN NECESSITIES
- A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
- A24D—CIGARS; CIGARETTES; TOBACCO SMOKE FILTERS; MOUTHPIECES FOR CIGARS OR CIGARETTES; MANUFACTURE OF TOBACCO SMOKE FILTERS OR MOUTHPIECES
- A24D3/00—Tobacco smoke filters, e.g. filter-tips, filtering inserts; Filters specially adapted for simulated smoking devices; Mouthpieces for cigars or cigarettes
- A24D3/06—Use of materials for tobacco smoke filters
- A24D3/067—Use of materials for tobacco smoke filters characterised by functional properties
-
- A—HUMAN NECESSITIES
- A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
- A24D—CIGARS; CIGARETTES; TOBACCO SMOKE FILTERS; MOUTHPIECES FOR CIGARS OR CIGARETTES; MANUFACTURE OF TOBACCO SMOKE FILTERS OR MOUTHPIECES
- A24D3/00—Tobacco smoke filters, e.g. filter-tips, filtering inserts; Filters specially adapted for simulated smoking devices; Mouthpieces for cigars or cigarettes
- A24D3/06—Use of materials for tobacco smoke filters
- A24D3/14—Use of materials for tobacco smoke filters of organic materials as additive
-
- A—HUMAN NECESSITIES
- A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
- A24D—CIGARS; CIGARETTES; TOBACCO SMOKE FILTERS; MOUTHPIECES FOR CIGARS OR CIGARETTES; MANUFACTURE OF TOBACCO SMOKE FILTERS OR MOUTHPIECES
- A24D3/00—Tobacco smoke filters, e.g. filter-tips, filtering inserts; Filters specially adapted for simulated smoking devices; Mouthpieces for cigars or cigarettes
- A24D3/18—Mouthpieces for cigars or cigarettes; Manufacture thereof
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
- C08J9/00—Working-up of macromolecular substances to porous or cellular articles or materials; After-treatment thereof
- C08J9/28—Working-up of macromolecular substances to porous or cellular articles or materials; After-treatment thereof by elimination of a liquid phase from a macromolecular composition or article, e.g. drying of coagulum
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
- C08J2201/00—Foams characterised by the foaming process
- C08J2201/04—Foams characterised by the foaming process characterised by the elimination of a liquid or solid component, e.g. precipitation, leaching out, evaporation
- C08J2201/048—Elimination of a frozen liquid phase
- C08J2201/0484—Elimination of a frozen liquid phase the liquid phase being aqueous
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
- C08J2305/00—Characterised by the use of polysaccharides or of their derivatives not provided for in groups C08J2301/00 or C08J2303/00
- C08J2305/04—Alginic acid; Derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
- C08J2405/00—Characterised by the use of polysaccharides or of their derivatives not provided for in groups C08J2401/00 or C08J2403/00
- C08J2405/16—Cyclodextrin; Derivatives thereof
Landscapes
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Materials Engineering (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Polymers & Plastics (AREA)
- Organic Chemistry (AREA)
- Cigarettes, Filters, And Manufacturing Of Filters (AREA)
Abstract
The invention relates to the field of tobacco industry, and provides a Chinese herbal medicine-supermolecule aerogel and a preparation method and application thereof, wherein the preparation method of the Chinese herbal medicine-supermolecule aerogel comprises the following steps: mixing supermolecule aerogel with solution of lipophilic Chinese herbal medicine component, soaking after ultrasound, and drying; the supramolecular aerogel is prepared from raw materials including sodium alginate and carboxymethyl cyclodextrin. Based on the cavity property of cyclodextrin, the Chinese herbal medicine components are combined into the cavity of the cyclodextrin through the actions of host and guest by ultrasonic and soaking, and the reticular porous Chinese herbal medicine-supermolecule aerogel is obtained after drying. The Chinese herbal medicine components in the aerogel are helpful for adsorbing or neutralizing harmful substances such as tar and the like, and the filtering effect on the tar is improved. In addition, these herbal ingredients can also positively affect the variety of tastes of cigarettes.
Description
Technical Field
The invention relates to the field of tobacco, in particular to a Chinese herbal medicine-supermolecule aerogel and a preparation method and application thereof.
Background
Tobacco has been a consumer product of life for refreshing, calming and soothing the spirit and has been in the history of human development. However, during smoking, the temperature of the tobacco is raised from normal temperature to 950 ℃, and in the process, the oxygen content, the combustion degree and the components of the cigarette are complex and various, and the combustion of the cigarette actually generates a series of chemical reactions in a carbonization, pyrolysis, condensation and other modes to generate smoke with extremely complex components. Researches show that 92% of cigarette smoke is gas such as carbon monoxide, hydrocyanic acid, ammonia and the like; 8% of the smoke dust with the particle size of 0.1-2 μm is particulate matters, the particulate matters are called tar, and nicotine, polycyclic aromatic hydroxyl, benzopyrene, beta-naphthylamine and the like are contained in the particulate matters, so that the particulate matters are main harmful matters of cigarettes.
At present, the technologies of tobacco tar reduction mainly include two types: firstly, the production amount of tar is reduced: for example, the tar content in the tobacco raw materials is reduced by agricultural measures, or the tar content in the cigarette products is reduced by technical measures such as adding tobacco sheets, adding combustion improver, expanding tobacco shreds, changing the specifications of cigarettes, reducing the tobacco shred quantity, reducing the suction port number of cigarettes and the like. Secondly, the flue gas filtration efficiency is improved: by changing the filter aids and parameters, adding adsorbents, etc.
However, these methods have little room for tar reduction at present, and low tar cigarette formulations have high tobacco quality requirements. In addition, compared with the gaps between acetate filaments in the cigarette filter tip (30-100 μm), the particle size of the tar is integrally and integrally smaller by an order of magnitude, so that the acetate filter tip has a relatively open structure to the cigarette smoke, and if the pores of the filter tip are blindly reduced, the combustion effect of the cigarette is affected.
Disclosure of Invention
Aiming at the problems existing in the prior art, the invention provides the Chinese herbal medicine-supermolecule aerogel and the preparation method and application thereof, which can achieve the effect of reducing tar while increasing the health degree and the taste of cigarettes.
In a first aspect, the present invention provides a method for preparing a herbal-supramolecular aerogel comprising: mixing supermolecule aerogel with solution of lipophilic Chinese herbal medicine component, soaking after ultrasound, and drying; the supramolecular aerogel is prepared from raw materials including sodium alginate and carboxymethyl cyclodextrin.
The hydrogel is a three-dimensional polymer network with extremely high hydrophilicity formed by crosslinking macromolecular polymer chains, has a large number of uniform pore diameters, and can obtain aerogel by losing moisture through freeze drying of the hydrogel, and the three-dimensional pore structure can be completely reserved in the process. The supermolecular aerogel disclosed by the invention refers to an aerogel containing supermolecules. Supermolecules are generally defined as complex, organized aggregates of two or more molecules held together by intermolecular interactions, and maintained in a degree of integrity that provides defined microscopic and macroscopic properties. Reported supermolecular macrocyclic hosts include DNA, crown ethers, cyclodextrins, calixarenes, calixapyrroles, calixazoles, cucurbiturils, pillar arenes, and the like.
Sodium alginate is a byproduct of brown algae kelp or gulfweed after extracting iodine and mannitol, and the molecule is formed by connecting beta-D-mannuronic acid (beta-D-mannuronic acid, M) and alpha-L-guluronic acid (alpha-L-guluronic acid, G) according to a (1- & gt 4) bond, is a natural polysaccharide, and has the stability, solubility, viscosity and safety required by auxiliary materials of a pharmaceutical preparation. Sodium alginate has been widely used in the food industry and in the pharmaceutical field.
Since the outer rim of cyclodextrin is hydrophilic and the inner cavity is hydrophobic, it can provide a hydrophobic binding site like an enzyme, as a Host (Host) enveloping various suitable guests (guests), such as organic molecules, inorganic ions, and gas molecules, etc.
Based on the cavity property of cyclodextrin, the Chinese herbal medicine components are combined into the cavity of the cyclodextrin through the actions of host and guest by ultrasonic and soaking, and the reticular porous Chinese herbal medicine-supermolecule aerogel is obtained after drying. Tobacco tar is an extremely complex mixture of numerous hydrocarbons and oxides, sulfides and nitrides of hydrocarbons, and the polarity of the aerogel network can be altered by modifying the oleophilic herbal ingredients such as menthol into the aerogel. The lipophilic aerogel is then implanted into a cigarette filter to increase the filter's effectiveness in filtering oily substances (e.g., tar, benzene derivatives) from the smoke to some extent. In addition, the Chinese herbal medicine components can positively influence the taste diversity of cigarettes through volatilization, and achieve the purpose of wetting the throat and clearing the throat of smokers.
According to the preparation method of the Chinese herbal medicine-supermolecule aerogel provided by the invention, the mass ratio of the sodium alginate to the carboxymethyl cyclodextrin is 3-5:1.
In some embodiments of the present invention, the preparation process of the herbal medicine-supramolecular aerogel comprises:
s1, weighing 5g of sodium alginate, dissolving in 100ml of distilled water to obtain 5% (W/V%) sodium alginate solution, and then weighing 1g of carboxymethyl cyclodextrin, dissolving in 5% sodium alginate solution.
S2, weighing 0.2g of calcium carbonate, adding the calcium carbonate into 20mL of the sodium alginate cyclodextrin solution, stirring vigorously to uniformly distribute the calcium carbonate in the sodium alginate cyclodextrin solution, adding 0.2g of gluconolactone, continuing stirring vigorously for 1min, and standing for gelling.
S3, freezing the prepared hydrogel for 24 hours at the temperature of minus 20 ℃, and then drying the hydrogel in a freeze dryer for 48 hours to obtain the supermolecule aerogel.
S4, putting the dried supermolecule aerogel into 99% menthol solution, carrying out ultrasonic treatment for 3 hours, then soaking for 24 hours, taking out, putting into an oven, and drying at 60 ℃ for 24 hours to remove menthol which is not complexed with cyclodextrin.
According to the preparation method of the Chinese herbal medicine-supermolecule aerogel provided by the invention, the lipophilic Chinese herbal medicine component is one or more of menthol, eucalyptus, origanum, clove, achyranthes bidentata, thyme, lemon and rose essential oil.
Further, when the lipophilic herbal ingredient is a solid, for example menthol crystals, a solution having a concentration of more than 95% is formulated using a solvent in which it is soluble;
when the lipophilic herbal ingredient is a liquid, such as menthol essential oil, it is directly mixed with the supramolecular aerogel.
Menthol is a kind of Chinese medicine extract, is a kind of terpenoid organic compound, has special fragrance of peppermint, and is cool after initial burning. Can be used as irritant in medicine, acts on skin or mucosa, and has effects of refreshing and relieving itching; it can be used as wind-dispelling medicine for treating headache, and inflammation of nose, pharynx and larynx. According to the invention, after menthol is modified into the supermolecule aerogel, substances such as tar in smoke can be better adsorbed, the taste of cigarettes can be increased, and menthol has the effects of clearing heat from throat and benefiting throat, so that the menthol plays a positive role in the health of smokers.
According to the preparation method of the Chinese herbal medicine-supermolecule aerogel provided by the invention, the ultrasonic power is 200-300W, and the time is 2-3h.
According to the preparation method of the Chinese herbal medicine-supermolecule aerogel provided by the invention, the soaking time is 24-48h.
According to the preparation method of the Chinese herbal medicine-supermolecule aerogel, the drying is freeze drying, and the treatment temperature of a sample before freeze drying is-80 to-20 ℃.
In a second aspect, the present invention provides a herbal-supramolecular aerogel prepared by the above-described preparation method.
In a third aspect, the present invention provides a method for reducing tobacco tar comprising disposing the above herbal-supramolecular aerogel in a cigarette filter.
In a preferred embodiment of the present invention, the Chinese herbal medicine supermolecule aerogel is made into a cylinder with the same diameter as the cigarette filter tip, and is arranged in the middle section of the cigarette filter tip, and the length of the cylinder is 1/5-1/3 of the cigarette filter tip.
Because the mesh porous structure of the prepared Chinese herbal medicine-supermolecule aerogel has more pore diameters and complex internal channels, the cigarette filter tip can not be directly used as the cigarette filter tip because the cigarette filter tip can not meet the smoking requirement of the cigarette, and the tar filter system of the cigarette is formed by combining the cigarette filter tip with the traditional cigarette filter tip. Compared with the traditional acetate fiber cigarette filter tip, the cigarette filter tip of the composite aerogel can intercept and adsorb tar in cigarettes through more proper pore diameter and added lipophilic Chinese herbal medicine components, and can adsorb some harmful free radicals in smoke through a principle of host-guest combination. Experimental data show that compared with the traditional single acetate fiber filter tip, the composite cigarette filter tip has better tar reducing effect, and the taste of the cigarette can be improved by selecting proper Chinese herbal medicine components.
The method of the invention is mainly aimed at the improvement scheme of reducing tar in the cigarette filter tip process. From the economical point of view, the materials used in the method are cheap and easy to obtain and are common raw materials in food and medicine processing; from the perspective of safety and health, the materials are widely used in the fields of medicines, foods and the like, and have no harm to human bodies; from the usability, the scheme not only can reduce tar and other harmful gas molecules in the smoke of the cigarette, but also can add some flavor and taste to the cigarette, thus being a new mode with various tastes. Therefore, the method has good application prospect, not only better ensures the health of vast smokers, but also provides more special fragrance for cigarettes.
The invention provides a Chinese herbal medicine-supermolecule aerogel, a preparation method and application thereof, wherein based on the cavity property of cyclodextrin, chinese herbal medicine components are combined into the cavity of the cyclodextrin through the actions of host and guest by ultrasonic and soaking, and the reticular porous Chinese herbal medicine-supermolecule aerogel is obtained after drying. The aperture of the dry aerogel is closer to the grain diameter of the large-size tar, and the large-size tar can be better filtered, so that the tar content in the flue gas is reduced. Meanwhile, the Chinese herbal medicine components in the aerogel are also beneficial to adsorbing or neutralizing harmful substances such as tar and the like, so that the filtering effect on the tar is improved. In addition, these herbal ingredients can also positively affect the variety of tastes of cigarettes.
Drawings
FIG. 1 is a scanning electron microscope image of a menthol-loaded supramolecular aerogel (the inset is a physical image of the supramolecular aerogel);
FIG. 2 is a schematic representation of the principle of an aerogel cigarette filter tip in tar (the inset is a pictorial view of the filter tip);
fig. 3 is a scanning electron microscope image of the menthol-loaded supramolecular aerogel after adsorbing smoke (the inset is a physical image of the supramolecular aerogel after smoking);
fig. 4 is an ultraviolet spectrum of the soaking solution after adsorption of smoke by menthol-loaded supramolecular aerogel (the inset is a physical diagram of each group of filters).
Detailed Description
For the purpose of making the objects, technical solutions and advantages of the embodiments of the present invention more clear, the technical solutions in the embodiments of the present invention will be clearly and completely described below, and it is apparent that the described embodiments are some embodiments of the present invention, but not all embodiments. All other embodiments, which can be made by those skilled in the art based on the embodiments of the invention without making any inventive effort, are intended to be within the scope of the invention.
Unless otherwise specified, the raw materials according to the examples of the present invention are all commercially available.
Example 1
The embodiment provides a Chinese herbal medicine-supermolecule aerogel, and the preparation method thereof is as follows:
(1) 5g of sodium alginate was weighed and dissolved in 100ml of distilled water to obtain a sodium alginate solution of 5% (W/V%), and then 1g of carboxymethyl cyclodextrin was weighed and dissolved in the sodium alginate solution of 5%.
(2) Weighing 0.2g of calcium carbonate, adding the calcium carbonate into 20mL of the sodium alginate cyclodextrin solution, stirring vigorously to ensure that the calcium carbonate is uniformly distributed in the sodium alginate cyclodextrin solution, then adding 0.2g of gluconolactone into the sodium alginate cyclodextrin solution, continuing stirring vigorously for 1min, and standing for gelling.
(3) Freezing the prepared hydrogel at-20 ℃ for 24 hours, and then putting the hydrogel into a freeze dryer for drying for 48 hours to obtain the supermolecule aerogel.
(4) And (3) putting the dried supermolecular aerogel into 99.9% menthol solution, performing 200W ultrasonic treatment for 3 hours, then soaking for 24 hours, taking out, putting into an oven, and drying at 60 ℃ for 24 hours to remove menthol which is not complexed with cyclodextrin, thereby obtaining the supermolecular aerogel loaded with menthol, wherein a microscopic scanning electron microscope image of the supermolecular aerogel is shown in figure 1.
The present example also applies the resulting herbal-supramolecular aerogel to cigarette filters for tar reduction testing.
The test method comprises the following steps: the filter of the cigarette was removed, cut from the middle, and 10mm cut off, and replaced with the prepared menthol-loaded supramolecular aerogel. The cigarette was used for cigarette tar filtering experiments, defined as menthol loaded aerogel cigarette filters, gel+m group. The principle schematic diagram of tar filtering is shown in figure 2.
The volunteers were selected to smoke the cigarettes prepared in this example, and the taste of the cigarettes was evaluated; the filter was then removed and the microstructure of the filter was examined, as shown in fig. 3. Finally, the filter tip is soaked in distilled water for 3 days, the soaking solution is diluted and then is subjected to ultraviolet spectrogram, the tar reducing effect of the cigarette filter tip is evaluated through the ultraviolet absorption peak of tar, the higher the absorption peak is, the higher the tar content is, and the result is shown in figure 4.
Comparative example 1
The cigarettes were not subjected to any operation, and the cigarette tar filtering experiments were performed using the original common filter tip (acetate), defined as the Blank group.
Selecting volunteers to smoke cigarettes prepared in the case, and evaluating the taste of the cigarettes; then taking out the filter tip, soaking in distilled water for 3 days, diluting the soaking solution, performing ultraviolet spectrogram, and evaluating the tar reducing effect of the cigarette filter tip through the ultraviolet absorption peak of tar, wherein the higher the absorption peak is, the higher the tar content is, and the result is shown in figure 4.
Comparative example 2
The comparative example provides a supramolecular aerogel, which is prepared as follows:
(1) Firstly, 5g of sodium alginate is weighed and dissolved in 100ml of distilled water to obtain 5% (W/V%) sodium alginate solution, and then 1g of carboxymethyl cyclodextrin is weighed and dissolved in 5% sodium alginate solution.
(2) Weighing 0.2g of calcium carbonate, adding the calcium carbonate into 20mL of the sodium alginate cyclodextrin solution, stirring vigorously to ensure that the calcium carbonate is uniformly distributed in the sodium alginate cyclodextrin solution, then adding 0.2g of gluconolactone into the sodium alginate cyclodextrin solution, continuing stirring vigorously for 1min, and standing for gelling.
(3) Freezing the prepared hydrogel at-80 ℃ for 24 hours, and then putting the hydrogel into a freeze dryer for drying for 48 hours to obtain the supermolecule aerogel.
The filter tip of the cigarette was taken out, cut off from the middle, and cut off 10mm, and the prepared supramolecular aerogel was used instead. The cigarette is used for cigarette tar filtering experiments, and is defined as a common composite cigarette filter tip and a Gel group
Selecting volunteers to smoke cigarettes prepared in the case, and evaluating the taste of the cigarettes; then taking out the filter tip, soaking in distilled water for 3 days, diluting the soaking solution, performing ultraviolet spectrogram, and evaluating the tar reducing effect of the cigarette filter tip through the ultraviolet absorption peak of tar, wherein the higher the absorption peak is, the higher the tar content is, and the result is shown in figure 4.
The filter tip of each of example 1 and comparative examples 1 to 2 was evaluated for the tar-reducing effect by the following method:
A. comparing the front and back scanning electron microscope images of the aerogel for filtering tar, observing the morphology change, and evaluating whether the aerogel can filter tar;
B. and comparing tar contents in the menthol-loaded aerogel composite filter tip, the common filter tip and the menthol-unloaded aerogel filter tip, and evaluating the performance strength of the aerogel filter tar.
C. The volunteers feedback the taste of each group of cigarettes.
The results were as follows:
A. the higher porosity of the prepared aerogel can be seen from fig. 1, which shows that the aerogel has a large specific surface area, and flue gas is easy to adsorb when passing through the aerogel. As can be seen by comparing fig. 3, the color of the aerogel changed after adsorbing the tar, and the microstructure became dirty, which suggests that a large amount of tar particles were adsorbed on the aerogel.
B. As can be seen from the comparison of the absorbance of the ultraviolet spectra of the groups in FIG. 4, the menthol-loaded composite filter (gel+M) has significantly better tar filtering effect than the conventional filter (Blank) and conventional composite aerogel filter group (Gel).
C. After the evaluation of each group of cigarettes by the volunteers, the volunteers know that the menthol-loaded aerogel composite filter cigarette feels obvious cool feeling in the process of smoking and in the oral cavity and throat after smoking.
While the invention has been described in detail in the foregoing general description and with reference to specific embodiments thereof, it will be apparent to one skilled in the art that modifications and improvements can be made thereto. Accordingly, such modifications or improvements may be made without departing from the spirit of the invention and are intended to be within the scope of the invention as claimed.
Claims (5)
1. The preparation method of the Chinese herbal medicine-supermolecule aerogel is characterized by comprising the following steps:
mixing supermolecule aerogel with solution of lipophilic Chinese herbal medicine component, soaking after ultrasound, and drying; the power of the ultrasonic wave is 200-300W, the time is 2-3h, and the soaking time is 24-48h; the drying is freeze drying, and the treatment temperature of the sample before freeze drying is-80 to-20 ℃;
when the lipophilic Chinese herbal medicine component is solid, preparing a solution with the concentration of more than 95% by using a solvent capable of dissolving the lipophilic Chinese herbal medicine component;
when the lipophilic Chinese herbal medicine component is liquid, directly mixing the lipophilic Chinese herbal medicine component with the supermolecule aerogel;
the preparation process of the supermolecule aerogel comprises the following steps: s1, weighing 5g of sodium alginate, dissolving in 100ml of distilled water to obtain a sodium alginate solution with a mass-volume ratio of 5%, and then weighing 1g of carboxymethyl cyclodextrin, dissolving in the sodium alginate solution with a mass-volume ratio of 5%; s2, weighing 0.2g of calcium carbonate, adding the calcium carbonate into 20mL of the sodium alginate cyclodextrin solution, vigorously stirring to uniformly distribute the calcium carbonate in the sodium alginate cyclodextrin solution, then adding 0.2g of gluconolactone, continuously vigorously stirring for 1min, and standing for gelling; s3, freezing the prepared hydrogel for 24 hours at the temperature of minus 20 ℃, and then drying the hydrogel in a freeze dryer for 48 hours to obtain the supermolecule aerogel.
2. The method for preparing a herbal-supramolecular aerogel according to claim 1, wherein the lipophilic herbal ingredient is one or more of menthol, eucalyptus, oregano, clove, achyranthes, thyme, lemon, rose essential oil.
3. A herbal supramolecular aerogel prepared by the method of claim 1 or 2.
4. A method for reducing tobacco tar comprising disposing the herbal-supramolecular aerogel of claim 3 in a cigarette filter.
5. The method for reducing tobacco tar according to claim 4, wherein the Chinese herbal medicine-supermolecule aerogel is made into a cylinder with the same diameter as the cigarette filter tip, and is arranged at the middle section of the cigarette filter tip, and the length of the cylinder is 1/5-1/3 of the length of the cigarette filter tip.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202211154119.5A CN115612183B (en) | 2022-09-21 | 2022-09-21 | Chinese herbal medicine-supermolecule aerogel and preparation method and application thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202211154119.5A CN115612183B (en) | 2022-09-21 | 2022-09-21 | Chinese herbal medicine-supermolecule aerogel and preparation method and application thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN115612183A CN115612183A (en) | 2023-01-17 |
| CN115612183B true CN115612183B (en) | 2023-12-29 |
Family
ID=84857869
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202211154119.5A Active CN115612183B (en) | 2022-09-21 | 2022-09-21 | Chinese herbal medicine-supermolecule aerogel and preparation method and application thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN115612183B (en) |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4889144A (en) * | 1987-05-29 | 1989-12-26 | Japan Tobacco Inc. | Filter for tobacco smoking |
| CN102266123A (en) * | 2010-06-07 | 2011-12-07 | 湖北中烟工业有限责任公司 | Beta-cyclodextrin composite particles capable of selectively reducing phenolic compounds in smoke gas and application of beta-cyclodextrin composite particles |
| CN105601983A (en) * | 2016-03-10 | 2016-05-25 | 云南中烟工业有限责任公司 | Natural polysaccharide aerogel, preparation method thereof and application thereof in cigarettes |
-
2022
- 2022-09-21 CN CN202211154119.5A patent/CN115612183B/en active Active
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4889144A (en) * | 1987-05-29 | 1989-12-26 | Japan Tobacco Inc. | Filter for tobacco smoking |
| CN102266123A (en) * | 2010-06-07 | 2011-12-07 | 湖北中烟工业有限责任公司 | Beta-cyclodextrin composite particles capable of selectively reducing phenolic compounds in smoke gas and application of beta-cyclodextrin composite particles |
| CN105601983A (en) * | 2016-03-10 | 2016-05-25 | 云南中烟工业有限责任公司 | Natural polysaccharide aerogel, preparation method thereof and application thereof in cigarettes |
Non-Patent Citations (2)
| Title |
|---|
| 基于羧甲基-β-环糊精功能材料的研究进展;李霞;谢龙;李巧玲;;高分子通报(第07期);全文 * |
| 李霞 ; 谢龙 ; 李巧玲 ; .基于羧甲基-β-环糊精功能材料的研究进展.高分子通报.2015,(第07期),全文. * |
Also Published As
| Publication number | Publication date |
|---|---|
| CN115612183A (en) | 2023-01-17 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| RU2436484C2 (en) | Cigarette filter containing vegetal material and cigarette | |
| CN101947435B (en) | Chitosan polycation additive for reducing phenols in cigarette smoke | |
| DE102005005175A1 (en) | Filter cigarette | |
| JP4963338B2 (en) | Cigarette smoke element and method for manufacturing the same | |
| CN102266123A (en) | Beta-cyclodextrin composite particles capable of selectively reducing phenolic compounds in smoke gas and application of beta-cyclodextrin composite particles | |
| WO2013045944A2 (en) | Smokeable element | |
| KR20030010166A (en) | A filtering material for cigarette and its process to use ginkgo leaf ingredients | |
| CN115612183B (en) | Chinese herbal medicine-supermolecule aerogel and preparation method and application thereof | |
| CN101141891B (en) | Instant tip rod appended solution when sucking cigarette and producing method and application | |
| CN104473328B (en) | A kind of cigarette coke tar filtering agent and its manufacture method and purposes | |
| CN1286408C (en) | Absorption additive chitosan-Cu compound used in cigarette filter tip and its preparation method | |
| CN110403236B (en) | Cigarette dry bead filter rod with function of improving smoke permeation | |
| RU2762867C1 (en) | Material for inclusion in the smoking article | |
| CN104473324A (en) | Application of cyclodextrin polymer for selectively reducing phenol content in cigarette smoke | |
| WO2008119261A1 (en) | Application of common rush in producing cigarettes | |
| KR100390575B1 (en) | A cigarette filter prepared from kittosan or kittosan fiber | |
| CN113057369A (en) | Paper filter stick and preparation method thereof | |
| CN109645566B (en) | Citrus peel filter stick porous material and preparation method and application thereof | |
| CN103271440B (en) | Cigarette purifying and harm-reducing reagent and particles and preparation method of cigarette and particles | |
| US5083578A (en) | Apparatus for removing toxic materials contained in tobacco and methods therefor | |
| CN113717440B (en) | Color-changing harm-reducing particle and preparation method and application thereof | |
| KR900007006B1 (en) | Method for preparing of cigarette filter | |
| CN109512011A (en) | A method of it reducing papermaking-method reconstituted tobaccos and burns paper as sacrificial offerings breath | |
| CN1515199A (en) | Keniding nano charcoal flaovur filter tip | |
| CN114931232B (en) | Heating cigarette cartridge and preparation method thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant |